HEART RHYTHM 2007May 9-12, 2007Denver, Colorado USA28th Annual Scientific Sessions of Heart Rhythm Society

HIGHLIGHTSSpringtime in the Rockies

Opening Plenary Session

Featuring the First Annual Heart Rhythm 2007 Founders’ Lectureship by Albert L. Waldo, MD

Sessions Offered Throughout the Week include:

9 AFib Summit Sessions

12 Case-Based Tutorials

92 Core Curriculum Sessions

24 Debates

6 Experts Unplugged

9 Featured Symposia

19 Meet the Expert Luncheons

14 Mini-Courses

47 Oral Abstract Sessions

6 Poster Sessions

19 Special Sessions

4 Translational Electrophysiology Sessions

Topics (Includes abstract sessions):

AFib Educational Initiative: 9 Sessions

Allied Professionals: 23 sessions

Basic/Translational Science: 24 sessions

Catheter Ablation: 32 sessions

Clinical Electrophysiology/Pharmacology: 24 sessions

Devices (Bradycardia, Tachycardia): 49 sessions

General Interest: 7 sessions

Heart Failure (includes implantable monitoring): 13 sessions

Noninvasive Evaluation: 16 sessions

Pediatric/Adult Congenital Heart Disease: 19 sessions

Regulatory/Health Policy/Education: 12 sessions

Special Sessions: 36 sessions

New This Year:� Abstract Sessions Schedule: new scheduling allows the opportunity to attend oral abstracts without missing any

invited speaker sessions.

� Abstracts Plus: Nineteen Oral Abstract Sessions will feature an Expert Commentator at the end of the session.

� AFib Summit: An intensive two-day summit on atrial fibrillation.

� AFib Trail: Over twenty additional sessions on various aspects of AF diagnosis, therapies and clinical guidelines.

� Enhanced Education Content for Fellows: multiple sessions to provide practical career guidance.

� Expanded Late-Breaking Clinical Trials are now featured in two special sessions.

� Founders’ Lecture: Albert Waldo, MD, FHRS, will present the first annual Founders’ Lecture during the OpeningPlenary Session.

� International Sessions: Entitled Primary Prevention of SCD: An International Perspective and Management of AF:A Worldwide Perspective, the sessions will showcase leaders from international heart rhythm societies.

� Translational Electrophysiology Sessions: Intended to help scientists better frame research questions in terms ofclinical problems while enhancing evidence-based practice of physicians.

Registration Hours

Registration is located in A Lobby and is open:

Tuesday, May 8 , 3:00 p.m. -7:00 p.m.

Wednesday, May 9, 6:30 a.m. -7:00 p.m.

Thursday, May 10, 7:00 a.m. -6:00 p.m.

Friday, May 11, 7:30 a.m. -7:00 p.m.

Saturday, May 12, 7:30 a.m. -1:00 p.m.

Poster Session HoursThe Wednesday Evening Poster Session and Reception will be held in the Wells Fargo Theatre Foyer, immediatelyfollowing the Opening Plenary Session. All other Poster Sessions (P2-P6) will be held in the Exhibit Hall.

Featured Poster Session and Reception (PI)Wednesday, May 9, 20075:45 p.m.–7:00 p.m.(Presenters available: 5:45 p.m.–7:00 p.m.)

Poster Session 2 (P2)Thursday, May 10, 20079:00 a.m.–12:00 Noon(Presenters available: 9:30 a.m.–10:30 a.m.)

Poster Session 3 (P3)Thursday, May 10, 20072:00 p.m.–5:00 p.m.(Presenters available: 3:30 p.m.–4:30 p.m.)

Poster Session 4 (P4)Friday, May 11, 20079:00 a.m.–12:00 Noon(Presenters available: 9:30 a.m.–10:30 a.m.)

HEART RHYTHM 2007

Poster Session 5 (P5)Friday, May 11, 20072:00 p.m.–5:00 p.m.(Presenters available: 3:30 p.m.–4:30 p.m.)

Poster Session 6 (P6)Saturday, May 12, 20079:00 a.m.–12:00 Noon(Presenters available: 9:30 a.m.–10:30 a.m.)

PROGRAM SESSIONS INCLUDE:

Mini-Courses:� Ablation of Ventricular Arrhythmias: Where We Are and Where We Are Going

� Advances in Ablation of VT and Atrial Flutter

� Arrhythmias Associated with Genetic and Metabolic Disorders

� Basics in Autonomic Evaluation and Managing Patients with Orthostatic Intolerance and Syncope

� Catheter Ablation for Tachycardias Associated with CHD

� Catheter Ablation in Unusual Clinical Circumstances

� Coding and Reimbursement from the Experts: Fundamentals and Challenging Cases

� The Dysfunctional Heart: The Beat Goes On. . . . through Science, Surgery and Support

� How the Experts Overcome Device Complications and Challenges: Pre-Recorded Live Cases

� Learning Fundamentals of EP: An Interactive Course

� Live Cases: How the Experts Perform CRT-D Implantations

� Management of Patients with Ventricular Arrhythmias and Prevention of Sudden Cardiac Death

� Monitoring with Implantable Devices

� The Role of Imaging in CRT Candidates/Recipients

Featured Symposia:� Ablation of AF: Teaming up with the Referring Doctors and Allied Professionals

� AF Guidelines: Evidence-Based Management In Perspective

� Avoiding Disasters: How to Minimize Complications with Device Implantations

� Emerging Experimental Models of Cardiac Arrhythmogenesis

� Emerging Imaging Techniques

� Epicardial Ablation for Atrial and Ventricular Arrhythmias: The Institutional Experience

� ICD Updates: The Hot Topics in ICD Therapy

� New Understanding of AF Mechanisms: From Molecule to Patient

� The Next Generation of Device Therapies for Heart Failure

Core Curricula:� The 3 D’s in ICD: Detection, Discrimination, Defibrillation

� ACLS Guidelines: What’s New

� Advanced Cardiac Imaging: New Frontiers in Electrophysiology

� AEDs: Data and Distribution

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� AF Ablation: Knowing Your Patients and Procedures!

� AF in Heart Failure

� AF Management in Patients with an ICD: From Drug Therapy to Ablation

� AF Therapies: Weighing Risks, Benefits and Patient Choices

� Anatomy for EPs

� Approaches to Ablation of VT in Patients with a Nonischemic Dilated Cardiomyopathy

� Arrhythmias in Inherited Cardiomyopathies

� Arrhythmias in the CCU

� Arrhythmogenic Right Ventricular Dysplasia in Adults

� Arrhythmogenic Right Ventricular Dysplasia in Children

� Atrial Lead Placement

� Autonomic Nervous System Dysregulation in the Young

� Careers in Academic EP: What the EP Fellow Needs to Know

� The Case for LV or BiV Pacing with Bradycardia Indications

� Case Management Approach for CRT from Implantation to Follow-Up

� Case Management Approach to Advanced Pacemaker Programming: On Sensors and Timing Features

� Catheter Ablation of Post-MI StateVT

� Clinical Fetal Electrophysiology

� Clinical Trial Design in Electrophysiology Comprehensive Care of the Heart Failure Patient with CRT

� The Congenital Heart Surgeon and the Electrophysiologist: Forging New Collaborations

� Cost Effectiveness of Arrhythmia Therapy

� Cryothermal Ablation and Other Energy Sources in Children and Patients with CHD

� Device Therapy and CHD

� Drug Therapy for AF

� Electrophysiologic Observations during AF Ablation

� Emerging Tools and Technologies in Catheter Ablation

� EP Clinic: Common Medication Issues for Allied Professionals

� Evaluation and Treatment of Vasovagal Syncope

� Exercise and Arrhythmogenesis

� Expanding Indications for ICDs

� Expression of Ion Channels: On the Way to Remodeling

� Gap Junctions as a New Target for Antiarrhythmic Therapy: The Class V Antiarrhythmic?

� Genetics of AF

� Has the Average Heart Failure Patient Been Studied in Primary Prevention Device Trials?

� Heart Rhythm Society Clinical Competency Statement: Impact and Future Training Requirements

� Hospital and Physician Reimbursement Issues

� Hot Issues in the Management of Syncope

� How Should We Pace the Ventricles?

� How the Experts Program ICD/CRT-D Devices and Improve Patient Outcomes

� Human Ventricular Restitution Properties and Fibrillation

� ICD Registry: Progress and Promise for the Future

� ICD Therapy in Inherited Arrhythmias

� Imaging during Ablation: Looking While Cooking—The First Course

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� Imaging during Ablation: Looking While Cooking—The Second Course

� Implications of Shock Therapies for Primary Prevention ICD/CRT Recipients

� Improving Patient Safety in the EP Lab

� Jeopardy: Trivia, Unknown Tracings and Challenging Cases

� Left Atrial Flutter after Ablation for AF

� The Light and Dark Side of Ventricular Pacing: How to Properly Pace the Ventricle

� Linking the Mind and the Heart in the Arrhythmia Patient

� Management of ICD Complications in Everyday Clinical Practice

� Managing Patients with Long QT Syndrome

� Maximizing the Benefits of EP Fellowship

� Mechanisms of Arrhythmias Related to Aging

� My Worst Device Nightmare

� Novel Pacing Concepts

� Novel Technology Breakthroughs in ICD Patient Management

� Outflow Ectopy: Not Always a Benign Entity

� Pacemaker Programming: From Trial Data to Troubleshooting

� Pharmacology for AF: Considerations for the Advanced Practitioner

� Practical Essentials on SVT

� Remodeling and Reverse Remodeling in Heart Failure: A Critical Therapeutic Target

� Remote Monitoring: Meeting Workflow Challenges in Patient Management

� Remote Patient Management in Clinical Practice: Evidence-Based Medicine or Toy?

� Resynchronization Therapy in Children and Patients with CHD

� Risk Stratification for Primary SCD Prevention

� Role of Cardiac Structure in Arrhythmogenesis

� Role of Magnetic and Robotic Navigation in Atrial and Ventricular Arrhythmias: Tricks and Pitfalls

� The Role of the Autonomic Nervous System in Ventricular Arrhythmias: Before, During and After

� Serious Psychological Issues in ICD Recipients

� Status of Current Ongoing CRT Trials

� Stem Cell Therapy: Relevance in Cardiac Electrophysiology

� Strategies for Ablation of Chronic Atrial Fibrillation I

� Strategies for Ablation of Chronic Atrial Fibrillation II

� Targeting the Arrhythmogenic Ventricular Substrate

� Ten Years of Cryo-Ablation: What Have We Learned?

� Three T’s in Congenital Heart Disease: Tetralogy, Transposition and Tricuspid Atresia

� Treatment Strategies for Arrhythmias in Single Ventricle Patients

� Troubleshooting Complex Pacemaker/ICD/CRT Tracings

� T-Wave Alternans: Mechanisms and Implications to Clinical Practice

� Unconventional Pacing Methods in Patients with a Primary Indication for Pacing

� Updates in Lead Extraction and Device Infection Management: How to Avoid Bad Outcomes

� Using Implantable Device Data to Guide Therapy for Arrhythmias and Heart Failure

� VF/CPR in the Young

� VT Ablation: Procedural Issues and Case Studies

� VT/VF Storm: Pathophysiology and Treatment Options

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� What Do We Do with Our CRT Non-Responders?

Special Sessions:� ABIM Board Recertification Prep Course: Cardiology Module Version 01-A

� ABIM Board Recertification Prep Course: CCEP New Recent Advances Module

� AF in the Elderly: Mechanisms and Management (Joint Session: Heart Rhythm Society and the Society ofGeriatric Cardiology)

� AFIB Summit Highlights Session

� Allied Professionals’ Orientation Session

� Arrhythmia and Device Patient Support Groups

� Douglas P. Zipes Lectureship

� Hands-On Session

� Heart Rhythm 2007 Opening Plenary Session and Awards Presentation

� Heart Rhythm Journal Presents Basic/Translational Science Talks

� Heart Rhythm Journal Presents Clinical EP Talks

� Heart Rhythm Society Research Fellowship Awards Session

� Highlights of Heart Rhythm 2007

� Improving Allied Professional Networks in the Heart Rhythm Society

� Late-Breaking Clinical Trials I

� Late-Breaking Clinical Trials II

� President’s Reception: State of the Society, Awards Acknowledgement, Installation of New President

� Town Hall: Remote Cardiac Monitoring - Revolution in Arrhythmia Care—Current and Future Issues withTechnology, Reimbursement, Surveillance and Liability

� Young Investigator Awards Competition

Case-Based Tutorials:� Arrhythmias in Athletes: Mechanisms, Prevention and Management

� Disease Management in Heart Failure: Promise of the Networked

� ECG Interpretation: Classic to Complex

� Efficient Diagnosis of PSVT in the EP Laboratory

� Entrainment: Principles and Practical Applications

� I Can’t Place the LV Lead on the Lateral Wall: What Are My Options?

� Interpretation of Unknown Tracings

� Lead Extraction: Tips and Tricks for Tough Cases

� Management of ICDs: Clinical Challenges for the Clinician

� The Electrical Nightmare: A Case-Based Approach

� The Pediatric or Congenital Heart Patient Who Taught Me the Most

� Why is VT Ablation Failing in This Patient?

Debates:

CONTROVERSIES IN BASIC/TRANSLATIONAL SCIENCE:

� Ion Channelopathies Contribute to Sudden Infant Death Syndrome

� What is the Source of Arrhythmogenic Dispersion of Repolarization in the Heart?

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CONTROVERSIES IN CATHETER ABLATION:

� Ablation of Stable VT Should Be Attempted in all ICD Patients

� Asymptomatic Ventricular Preexcitation Should Be Eliminated

� An Advanced Mapping System Should Be Used for Most Ablation Procedures in 2007

� Catheter Ablation Is Not Appropriate Therapy for Inappropriate Sinus Tachycardia

CONTROVERSIES IN CLINICAL EP/PHARMACOLOGY:

� All Patients with a Positive Brugada ECD Should Undergo EP Testing

� Drugs that Produce Minor Changes (�10 msec) in QTs Can Be Used Safely

CONTROVERSIES IN DEVICES (Brady, Tachy):

� All Heart Failure Patients Treated with a BIV Device Require Defibrillator Backup

� All Patients with an Indication for CRT Should Undergo a Viability Study before Device Implant

� The LV Lead Should Be Left on the Septum When Transvenous Lateral Wall Pacing Is Not Feasible

� Patients with Structural Heart Disease, a Hemodynamically Stable VT and EF� 40% Should Not Receive an ICD

� Recalled Devices Should Not Routinely Be Explanted

� Remote Programming of Cardiac Implantable Electronic Devices Should Not Be Done Now or Ever!

� Shock Testing Is No Longer Needed with ICD Implantations

� Stand Alone Implantable Monitoring Will Never Be Viable!

CONTROVERSIES IN HEART FAILURE (includes implantable monitoring):

� Echocardiograhic Criteria Should Not Be Used to Select CRT Candidates

� Modest Mortality Benefits, Risk of Inappropriate Shock and Device Safety Issues Argue against PrimaryPrevention ICD Therapy for the Majority of Heart Failure Patients

CONTROVERSIES IN NONINVASIVE EVALUATION:

� All Asymptomatic Patients with a Brugada Pattern Should Receive ICD Therapy

� EF is the Only Risk Stratifier Needed for Prevention of SCD in Patients with Ischemic Heart Disease

CONTROVERSIES IN PEDIATRIC/ADULT CONGENITAL HEART DISEASE:

� In Patients Who Have Had Atriopulmonary-Style Fontan and Medically-Resistant IART, Operative Maze is theFirst Procedure of Choice

� In Young Patients and Patients with CHD, All Failed Transvenous Device Leads Should Be Extracted at Time ofDevice Replacement

CONTROVERSIES IN REGULATORY/HEALTH POLICY/EDUCATION:

� Industry Should Disclose All Low-Frequency Device Malfunctions

� Neonatal Screening for Long QT Syndrome Should Be Recommended

Experts Unplugged Luncheon Sessions:� Anne Curtis

� Blair Grubb

� Chu-Pak Lau

� Douglas Packer

� Eric Prystowsky

� Melvin Scheinman

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� Warren Jackman

� William Stevenson

Meet the Expert Luncheon Panels:� Acquired Forms of Long QT: Mechanisms and Treatment

� Arrhythmia Triggers

� Developing Your Academic Career under the Current State of Federal Funding

� Drug Development and the QT Interval

� Heart Rhythm Society/Industry Dialogue 2007

� How Can I Optimize My EP Lab Activity?

� How the Experts Interpret Difficult Pacemaker and ICD Tracings

� How the Experts Quickly Implant Devices and Avoid Complications

� How to do Cardioversion of AF in 2007

� Integrating Remote Monitoring into Your Practice

� The Interaction of Clinicians and Industry: EP System Interoperability

� Life after Fellowship: What the EP Fellow Needs to Know

� Management of AF: A Worldwide Perspective (Joint Session with COPE)

� The Pediatric EP as an ECG Consultant for the Primary Care Provider

� Post-Marketing Device Surveillance

� Primary Prevention of SCD: An International Perspective (Joint Session with COPE)

� Psychosocial Impact of Device Therapy in the Young

� Remote Monitoring: What’s New and What Are the Reimbursement Challenges?

� Why Is This Patient Experiencing Recurrent Arrhythmias after Ablation?

Oral Abstract Sessions:� Ablation of AF: Safety First

� Ablation of VT

� AF Ablation: Long-Term Outcomes

� AF Mechanisms and Management

� AF Therapy: Mechanistic Approaches

� Allied Professionals Research in Patient Care Improvements

� Allied Professionals: Interesting Case Presentations

� Arrhythmias in CHD: Pediatric and Adult

� Autonomic, Functional, and Age-Related Arrhythmias

� Basic Approaches to Ventricular Arrhythmias

� Case Studies: Important Lessons

� Cell Physiology, Pharmacology and Signaling

� Challenges in Device Management

� Clinical Reports with ICD and CRT Therapy

� Clinical Trials: What’s New and What’s Needed

� CRT for Heart Failure Management

� CRT Implantation: Meeting the Challenge

� Device Therapy in Children and Adults with CHD

� Electrophysiology Evaluation of VT

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� Experimental Methods in Ablation: A Potpourri

� Heart Failure Outcomes with CRT

� ICD/CRT Technology: Latest Developments Implantable Devices: Hemodynamics, Sensors, Outcomes

� Implantable Devices: Impact on AF

� Inherited Arrhythmia Syndromes

� Innovations in Arrhythmia Health Care

� Innovations in CRT

� Innovations in Noninvasive Arrhythmia Assessment

� Mapping and Ablation of AF: Case Studies

� Mapping and Ablation of Ventricular Arrhythmias: Cases from the EP Lab

� Mechanisms of Cardiac Alternans in Health and Disease

� Modifiers, Handlers and Chaperones

� Neurocardiogenic Syncope: New Insights and Approaches

� New Frontiers in Ablation of AF

� New Insights into ICD Outcomes

� New Modalities and Models for Cardiac Electrical Imaging

� Novel Basic Approaches to AF

� Pacing Lead Placement: Choose Your Site Wisely

� Pacing Potpourri

� Pediatric Arrhythmias: New Insights and Therapies

� Risk Stratification for Sudden Death

� SCD Risk Stratification: The Struggle Goes On

� Strategies for Ablation of AF

� SVT: Mechanism-Based Diagnosis and Therapy

� SVT: Mechanisms and Clinical Outcomes

� Syndromes and Genomics

� VT Syndromes: New ECG Insights

TYPES OF INVITED SPEAKER SESSIONS

AFib SummitSession Times: Vary2 Chairs; 4-5 Faculty Members

� Similar format to Core Curricula (see below)

� Faculty receive a maximum presentation time of 20 minutes

Case-Based TutorialsSession Time: 1 Hour 30 minutes1 Chair; 2-4 Faculty Members

� Teaching groups that encourage audience discussion as the presenters review cases chosen by the faculty as wellas the attendees.

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Core Curricula

2 Chairs; 3-4 Faculty Members� Didactic teaching sessions in all major specialty categories. The Scientific Sessions Program Committee provides

the faculty members’ topics.

� Faculty receive a maximum presentation time of 20 minutes; generally a 10-minute presentation and a 10-minutequestion and answer session

� At times, the Chair will also present a topic.

Debates

Session Time: 45 minutes; includes a Ten-Minute Rebuttal1 Chair; 2 Faculty Members

� Spirited debate sessions on controversial issues.

� The Chair will give a five-minute introduction.

� There will be a 15-minute presentation from the Protagonist followed by a 15-minute presentation from theAntagonist, then a ten-minute rebuttal period.

Experts Unplugged

Session Time: 1 Hour

1 Expert� Small intimate, lunchtime talks (approximately 40 attendees), covering various areas of expertise.

� There is only one faculty member in each of the sessions being offered.

� Experts conduct their talks without the use of audiovisual aids

� An additional fee is required. Seating is very limited. Tickets are available on a first-come first-served basis.

Featured Symposia

Session Time: 1 Hour 30 minutes

2 Chairs; 3-4 Faculty Members� Showcase sessions surrounding a central theme with faculty known as experts in their subject area.

� Each faculty member generally receives15 minutes of presentation time.

� There is a 30-minute period at the end of the session for questions and answers.

� The Scientific Sessions Program Committee selects the faculty’s topics.

Hands-On Session

Session Time: 4 hours1 Chair1 Session Offered on Wednesday

� Allows attendees to meet with industry representatives to learn about the newest equipment and clinically-releaseddevices and systems.

Meet the Experts Luncheon Panels

Session Time: 1 Hour1 Chair; 2-3 Faculty MembersOffered on Thursday and Friday ONLY

� Small discussion sessions or roundtables with active interaction between faculty and participants

� Faculty conducts this session without audiovisual aids

� The Scientific Sessions Program Committee provides the session’s topic, with the faculty usually determiningsubtopics, guided by the Chair.

� The first 20-30 minutes usually includes lunch.

� An additional fee is required. Seating is very limited. Tickets are available on a first-come first-served basis.

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Mini-CoursesSession Time: 3 Hours w/30 minute break2 Chairs; 3-5 Faculty MembersOffered on Wednesday ONLY

� Three-hour didactic teaching courses on “hot and new” topics.

� The Scientific Sessions Program Committee usually selects the faculty’s topics.

� Speakers receive a maximum of 30 minutes of presentation time.

� 30 minutes are reserved at the end of the session for questions and answers

� An additional fee is required. Tickets are available on a first-come first-served basis

Special SessionsSession Time: variesChairs and Faculty: varies

� Meetings, receptions, and spotlighted presentations comprise this session type.

� Faculty and chairs receive special instructions regarding their responsibilities from a Heart Rhythm Society staffliaison

� 2007 Sessions listed as a Special Session include:

� ABIM Re-Certification Courses

� Health Policy Town Hall Meeting

� Two Allied Professionals Networking Luncheons

� Two lunchtime talks sponsored by Heart Rhythm Journal

� Young Investigators Awards Competition

Translational Electrophysiology SessionsSession Time: 1 hour, 30 minutes1 Translator, 3 to 4 faculty members5 sessions offered (one is a featured symposium)

� This new session format allows clinicians and scientists to come together with the assistance of a carefully selectedexpert “Translator” presiding over the session.

� Translator will introduce the session for 5 minutes

� Each presenter gets 15-23 minutes total presentation time (depending on number of faculty in the session)

� Translator will ask questions during each presentation, as well as moderate a 10 minute discussion with attendeesafter all presentations.

TYPES OF ABSTRACT SESSIONSOral Abstract Sessions (AB)

� 10 minute presentation with five minutes at the end for questions and answers

� Six abstracts are presented within a sessionPlease note the numbering format:

Example: AB 1-1AB represents an oral abstract presentation.The first number (1) represents the oral abstract session number.The next number (1) indicates the number in which the abstract will be presented.

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Poster Sessions (P)� The Featured Poster Session and Reception (P1), highlights high-scoring abstracts from all abstract submission

categories. Presenters are requested to be present for the entire period.

� Poster Sessions 2 – 6 (P2-P6) are presented throughout the week. The Poster Sessions are three hours in duration;however, presenters need to be available for a 1-hour time slot.

Please note the numbering format:Example: P4-18P represents a poster presentation.The first number (4) represents the poster session number.The next number (18) represents the number of the poster within the poster session.

Acknowledgement

The Heart Rhythm Society and Elsevierwish to thank the following companies

for contributing generous educational grantsto support the production of this program and abstract issue:

St. Jude Medical

Boston Scientific

Thank You!

HEART RHYTHM 2007