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From Bench to Bedside

An up-to-date look at HIV Vaccine Research and HIV drugs in the pipeline

HIV Globally

40 million infected with HIV worldwide

Over 20 million have died since 1981

5 million were infected in 2004

600 new infections every hour

The World needs an HIV Vaccine

The World needs an HIV Vaccine

AIDS kills more people than any other infectious disease

History of Public Health Initiatives

Economics

AIDS kills more people than any other infectious disease

History of Public Health Initiatives

Economics

Is an AIDS vaccine really possible?

Is an AIDS vaccine really possible?

In 1984 researchers predicted that a vaccine was right around the corner…

In 1984 researchers predicted that a vaccine was right around the corner…

What are the steps in Vaccine development?What are the steps in Vaccine development?

Phase I: 10-30 volunteers, 8-12 months

Phase II: 50-500 volunteers,18-24 months

Phase III: Thousands of volunteers, 3 or more years

Phase I: 10-30 volunteers, 8-12 months

Phase II: 50-500 volunteers,18-24 months

Phase III: Thousands of volunteers, 3 or more years

Progress toward AIDS vaccine since 2000

Progress toward AIDS vaccine since 2000

30 AIDS vaccines in small-clinical trials

Developing countries taking a leadDemonstration that large scale AIDS

vaccine trials can be conducted

30 AIDS vaccines in small-clinical trials

Developing countries taking a leadDemonstration that large scale AIDS

vaccine trials can be conducted

What are the animal models for HIV

vaccines?

What are the animal models for HIV

vaccines?

MacaquesChimpanzees

What types of HIV vaccines are being

tested?

What types of HIV vaccines are being

tested?Peptide epitopes (protein fragments)

Status: In phase I trials

Live attenuated HIVStatus: Non-human primates

Whole, killed HIVStatus: Not under study in primates

Naked DNAStatus: Phase I trials

What types of HIV vaccines are being

tested?

What types of HIV vaccines are being

tested?Recombinant Viral ProteinsStatus: Phase II and III trials

Live bacterial vectorsStatus: Phase I trials

Live Viral VectorsStatus: Phase II trials

PseudovirionsStatus: Pre-clinical trials

What are the possible HIV vaccine outcomes?What are the possible HIV vaccine outcomes?

Sterilizing ImmunityTransient InfectionLong-term controlled infectionAltruistic vaccine

Who is organizing the HIV vaccine trial movement?

“Our goal is to develop safe and effective preventive HIV vaccines that will work everywhere on the globe, against all strains of HIV, in all people.”

What are some of the current HIV vaccine

trials?

What are some of the current HIV vaccine

trials?Phase I trial-

Product: AVX101Company: Alphavax Inc.

Safety of an HIV vaccine in HIV uninfected volunteers in United States and South Africa

What are some of the current HIV vaccine

trials?

What are some of the current HIV vaccine

trials?Phase II

Product: rgp 120 MNCompany: VaxGen

Study the immune system response to vaccine in Brazil, Haiti, Trinidad and Tobago

What are some of the current HIV vaccine

trials?

What are some of the current HIV vaccine

trials?Phase III

Products: ALVAC vCP1521/

AIDSVAX B/ECompany: Aventis,

VaxGenAssessing immunogenicity and ability to prevent HIV infection in Thailand

Where are these vaccines being tested?

What needs to happen to actually have an HIV vaccine?

Imagine a world without AIDS

Imagine a world without AIDS

No country, region or community is immune to HIV

All must play a role in vaccine development

No country, region or community is immune to HIV

All must play a role in vaccine development

What can you do to stay informed about HIV vaccines

and HIV/AIDS?

What can you do to stay informed about HIV vaccines

and HIV/AIDS?

Join HPSAAN and stay informed!www.amsa.org/global/hpsaan.cfm

Participate in an AIDS Vaccine Trial: www.hvtn.org

Join HPSAAN and stay informed!www.amsa.org/global/hpsaan.cfm

Participate in an AIDS Vaccine Trial: www.hvtn.org

Go to www.iavi.org/callforaction and sign-on !

Sources:Sources:International AIDS vaccine initiative

http://www.iavi.org/HVTN

http://www.hvtn.org/index.htmlDNA vaccines

http://people.ku.edu/~jbrown/dnavac.htmThe Pipeline Project

http://chi.ucsf.edu/vaccines/vaccines?page=vc-00-00

NIAID Division of AIDShttp://www.niaid.nih.gov/daids/vaccine/overview.htm

International AIDS vaccine initiativehttp://www.iavi.org/

HVTNhttp://www.hvtn.org/index.html

DNA vaccineshttp://people.ku.edu/~jbrown/dnavac.htm

The Pipeline Projecthttp://chi.ucsf.edu/vaccines/vaccines?page=vc-00-

00NIAID Division of AIDS

http://www.niaid.nih.gov/daids/vaccine/overview.htm