HLA B27

Seronegative Spondyloarthropathies

By Surijdei Amanda DeCruiz

HLA B27 HLA-B27Seronegative spondyloarthropathies HLA-B27 Human Leukocyte AntigenClass I Surface Antigen encoded in the B locus in MHC (Major Histocompatibility Complex) on Chr. 6p Blood test that detects proteins (HLA) located on the surface of WBCsFunction is to present the antigens to T-lymphocytesHLA proteins allows the body to distinguish between its own cells vs. foreign cellsPositive HLA-B27 = Abnormal = Increased Risk of developing Autoimmune DiseaseNegative for Rheumatoid factorPredilection for the Spine/Sacroiliac Joint, Enthesapothy, UveitisDo not Treat with Corticosteroids

HLA-B27 Seronegative spondyloarthropathies Ankylosing SpondylitisArthritis associated with Inflammatory Bowel Disease (Ulcerative Colitis and Crohns Disease) Psoriatic Arthritis Reactive Arthritis (Reiters syndrome)Juvenile Rheumatoid Arthritis (Adult Onset Stills Disease)

Ankylosing SpondylitisYoung Male (