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A global leader in the pursuit of human well-being and health through genome-based personalized medicine THERAGEN ETEX
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A global leader in the pursuit of human well-being and health through genome-based personalized medicine

THERAGEN ETEX

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Table of Contents

About UsⅠ Vision and Mission

Collaboration

Business Strategy and Network

Collaboration and Network

Service Portfolio

Research Performance

About Our People

Status of Equipment

Server Resources

Certification Program

History

Research and Resources

Ⅱ Services TotalOmics

Oncomics

GenomeReport

Array

HelloGene

GeneStyle

Pharmaceutical Division

- Etex Pharma

Subsidiary Companies

- MedPacto

- GenomeCare

- LeadPharm

- TheragenHealthcare

01 THERAGEN ETEX_Genomic innovations, Healthcare solutions

Greetings

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THERAGEN ETEX_Genomic innovations, Healthcare solutions 02

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Greetings

Theragen Etex is a genome specialized company

that carries forward the development of precision

medicine and new drugs based on cutting-edge

genome decoding technology and bioinformation.

Theragen Etex's genome analysis technology has

been proven through numerous articles published in

leading scientific journals.

We are providing research services for various spe-

cies using our own technology and individual

customized gene analysis services such as the

disease susceptibility of human beings, physical

characteristics, response to drugs.

Based on this gene analysis technology, Theragen

Etex is making every effort to realize customized

medicine and become a global leader in the pursuit

of human welfare and health.

03 THERAGEN ETEX_Genomic innovations, Healthcare solutions

FOUNDER & VICE CHAIRMAN

CEO & PRESIDENT

Seong-Jin Kim

Tae-Soon Hwang

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THERAGEN ETEX_Genomic innovations Healthcare solutions 04THERAGEN ETEX_Genomic innovations, Healthcare solutions 04

I About Us

Theragen Etex is a company specializing in the development of diagnostic solutions and new drugs using genome

analysis information. Based on individual gene analysis, the Genome Research Center identifies diverse genome

information in a specific disease and is developing new customized drugs based on this at the New Drug Research

Center. Theragen Etex is making every effort for the development of customized medicines specialized for individu-

als by analyzing and data basing the genome of diverse species and finding new drug target materials through the

discovery of genetic change information related to the diseases (genetic disease, cancer). Theragen Etex is the fifth

company in the world that identified human genome maps and has the best genome analysis technology in the

industry. In June 2013, we identified the world's first Korean gastric cancer gene. In January 2014, we were recog-

nized as the world's first to complete the map of the Minke whale genome, thereby decorating the cover of Nature

Genetics. In addition, we began our first step into the overseas market with an individual genome analysis service

(Hellogene) contract with UNIMEX in The Philippines in 2011. We completed an agreement with the Hwangseok

Health Examination Center to enter into the individual genome analysis service in China. Through this, we are

establishing a foothold for the advancement into the global market by constituting Asian genetic information and

networks such as the establishment of a local corporation to expand into other countries (Asia including the Philip-

pines and Thailand) in the future.

The SeviceProvider on

Genome Research

Sequencing

Array Bioinformatics

Software&

Server

B2BNBM

Data-driven

4th industry

TreatmentDiagnosis

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05 THERAGEN ETEX_Genomic innovations, Healthcare solutions

01 Vision and Mission

02 Collaboration

Theragen Etex Bio Laboratory is a "global leader in the pursuit of human wealth and health through

genome based customized medicine" and is practicing the following missions through genome based

total services.

Product development through base clinical research

Customer tailored services through genome data solutions

Promotion of health and welfare through the analysis of human genome data

1

2

3

Bio InstituteGenome research services

Individual gene analysis services

Software and server sales

R&D of diagnostic solution

Pharmaceutical DivisionSynthetic new drugs and bio new drugs

Manufacture and sale of improved new drugs

(Respiratory, gastrointestinal

circulatory diseases)

Genome Care Co. LtdNoninvasive antenatal congenital anomaly test

LeadPharm Co., LtdPharmacy chain business and license business

MedPacto, Inc. New drug development

Theragene Health Care, Inc. Medical supplies manufacturing and distribution

Theragen Etex Subsidiary companies

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03 Business Strategy

THERAGEN ETEX_Genomic innovations, Healthcare solutions 06

Based on genome analysis technologies and solutions, Theragen Etex providesnew drug development, pharmaceutical business, clinical services, and healthcareservices. We are expanding our network to lead the era of precision medicine witha pipeline that incorporates open innovation between group companies.

New drug development

MedPacto, Inc.

Sales anddistribution

LeadPharm Co., Ltd

New drugmanufacturing

Theragen Etex,Pharmaceutical

Division Inc.

Clinical service

Genome Care Co., Ltd.

Health care

TheragenHealth Care, Inc.

Genome based R&D

Theragen Etex Bio Institute

Restructuring

& R

einforcement

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04 Strategic Partnership and Network

07 THERAGEN ETEX_Genomic innovations, Healthcare solutions

Over 650 medical institutions

(as of 2017)

Domestic Partners

As of 2017, we provide services to more than 650 medical institutions. Based on the technology of genome analysis of domestic partner institutions, we are making efforts to provide better genome information services as well as new product development by carrying out joint development with research institutes and government agencies. In addi-tion, Theragen Etex aims to contribute to the improvement of human welfare through genome innovation by establishing strategic partnerships, based on trust, with overseas global companies.

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THERAGEN ETEX_Genomic innovations, Healthcare solutions 08

Based on infrastructure, Theragen Etex is expanding its business into each country. Through many years of transactions, we have steadily established ourselves as a reliable company from partner companies. With diverse genome analysis services, we connect customers and companies around the world and provide services under stable cooperation.

05 Service Portfolio

service portfolio

Research Centered Service Commercial Service

Theragen DXHellogene

TotalOmics OncomicsAdvanced Analysis Array Service

New Drug Development

● Direct-to-consumer service

● Skin

● Hair

● Fitness

● Advanced BI

● BIT system, DB

● Molecular sarcoma

●Genome report

● Cancer

● Common disease

Platinum Lite●

● Noble

● Kids

● Metabolic syndrome

● SNP Chip

● Customized Chip

● Korean SNP Chip

● GWAS Support

● Exome Sequencing

● Transcriptome Sequencing

● Whole Genome Sequencing

● Meta Genome Sequencing

● Epigenome Sequencing

● De novo

● Cancer Panel

● Liquid Biopsy

● BRCAinside

● Genomom

● Cancerinside

● OncoChaser

● Marker Development

● Preclinical Support

● Clinical Support

● Companion diagnostics

Hellogene Dental●

● Platinum

GeneStyle

Overseas Partnership

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09 THERAGEN ETEX_Genomic innovations, Healthcare solutions

The TotalOmics solution is a next-generation genome research service that provides sequence decoding and an analysis solution for all genome areas. Theragen Etex pro-vides genome decoding and analysis for the whole genome, transcriptome, epigenome and exome with professional skills based on the experience of the first Korean genome decoding and analysis. Leading genome (De novo) or reference-based genome decod-ing is all possible, including genome decoding and analysis for a variety of life forms, such as humans, many other animals/plants, and bacteria with high GC content rates.

Methyl decoding

Bisulfite decoding

MeDIP decoding

ChIP decoding

Transcriptome decoding

Small RNA decoding

Bacteria genome decoding

Meta-genomics decoding

Fungi(mildew, mycete) decoding

Meta 16rDNA decoding

Genome•Exome decoding/analysis products

Microorganism genome decoding/analysis products

Transcriptome decoding/analysis products

Epigenome decoding/analysis products

WGS

De novo decoding

Exome decoding

Target Area decoding

II Service 01 TotalOmics: Next generation Base Sequence Analysis Service www.theragenetex.com/kr/bio/services/totalomics/

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THERAGEN ETEX_Genomic innovations, Healthcare solutions 10

02 Oncomics: Cancer gene analysis service www.theragenetex.com/kr/bio/services/oncomics/

Since many known cancers are highly associated with genetic mutations, the identification of mutations through current genome analysis has become an important method for diagnosis and therapy. Oncomics is a service that decodes using the next generation base sequence by utilizing a small amount of blood or cancer tissue and then accurately analyzing the mutation. Through testing, a prescribed targeted medicine will minimize the side effects of the drug, and thereby increase the success rate of cancer treatment.

| Periodic Precision Inspection of Cancer |

DiagnosisEarly detection of cancer

Simple blood test allows early detection of cancer

Treatment

Proceed with therapeutic intervention by classifying patients according to genetic variation.

Customized treatment with consideration of drug resistance is possible. Optimize the treatment effect customized to patients and minimize side effects.

RecurrenceTrack whether cancer recurs

Precise monitoring of recurrent cancer by periodic blood tests after treatment

Theragen Etex Cancer Analysis Service

Oncomics·Clinical study using cancer panel

Liquid Biopsy·Cancer analysis using cancer DNA

in blood

BRCAinside·Breast Cancer/Ovary Cancer Inspection Service

OncoChaser·Non-invasive cancer recurrence check service

CancerInside·Cancer family history screening service

NGS Clinical Research Domestic No.1 NGS Clinical Research Approval from Ministry of Food and Drug SafetyUsing NGS (Next Generation Sequence) devices, which were used for research purposes, it is the

first laboratory in Korea to be certified as a food service place. We utilize the decoding and analysis

technology accumulated over many years for clinical use.

In accordance with Article 20 (2) of the Regulations on Medical Device Permits, Notifications

Research Diagnosis

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11 THERAGEN ETEX_Genomic innovations, Healthcare solutions

04 Array: Genome Chip Analysis

The microarray is a technology that can identify thousands to tens of thou-sands of genes with a single experiment and is used for gene function prediction, disease classification, and diagnosis. Increases in the occur-rence rate of hereditary diseases, awareness of customized medical treat-ment, demand for drug genomics in drug discovery, and use of livestock are driving market growth. In addition to the chips commercialized with many experiments and analysis experiences, we are providing accurate results by producing customer tailored arrays.

The Korea Centers for Disease Control and Prevention has developed arrays optimized for Koreans by studying disease-related genetic factors that appear in Koreans. We provide services for the developed arrays to be utilized for Korean research.

Chip for orean

PMRA consists of 903,000 genetic markers that can identify SNPs and CNVs that are closely relat-ed to diseases, enabling us to conduct precision medical research in an efficient way.

PMRA (Precision Medicine Research Array)

03 Genome-Report: Automated Analysis Report www.genome-report.com

Genome-Report is a system that makes it easy to analyze complicated bioinformation analysis on the web. More than 30 bioinformatics professionals have been building an optimal pipeline through various analysis experiences, and the developed Genome-Report provides efficient and advanced analysis results.

Service Type

Service by array type

Analysis of gene expressionlevel and expression level difference

Describe the various mechanisms and phenomena of living organisms by comparing gene expression level and difference in gene expression level

Analysis that detects gene mutationsGenetic mutation

Somatic mutation

Gene fusion

Protein structure prediction

Identify significant somatic mutation and causative mutation in cancer disease

Identify gene fusion that is a key to cancer genome research

Predict protein structure changes according to RNA sequence

Microarray

Korean SNP Chip

PMRA

OpenArray

HelloGene

GeneStyle

. . .

. . .

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It is the time to break away from health care that has been done in the same way for everyone and more towards the neces-sary that is individual custom-ized health care that is differen-tiated according to individual genetic diversity. Finding your own DNA secret will become the best strategy to protect your health and life.

Macular development

Glaucoma

DiabetesHigher than the average

High

Very high

Changes in the medical paradigm, from cure to care

The healthcare service that shows the possibility of developing a specific disease by using a genetic marker as an indicator is recording a high share in the domestic market. Using verified and highly reliable genetic markers, we provide a variety of useful information about various diseases such as cancer, general diseases, food and drug reactions, and physical characteristics.

THERAGEN ETEX_Genomic innovations, Healthcare solutions 12

05 HelloGene : Personal Gene Analysis Service www.hellogene.com/kor/hellogene

HelloGene service is

Intake of Omega-3 fatty acid with preventive effect

Regular intraocular pressure measurement

Diet Control Periodic exercise program

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13 THERAGEN ETEX_Genomic innovations, Healthcare solutions

GeneStyle Hair Inspect the genetic characteristics that affect hair loss to identify the risk of hair loss and analyze the optimal scalp hair care method for you.

GeneStyle Direct GeneStyle Direct is a gene test service that helps individuals manage their health and beauty by analyzing the genetic characteristics of individuals based on 41 genetic indicators recognized by the Ministry of Health and Welfare. We are providing health functional food elements recommended by doctors and pharmacists and cosmetic ingredients and management methods recommend-ed by cosmetics experts and differentiated solutions. Currently, it is sold offline in about 200 pharmacies nationwide and online through hellogene.com.

06 GeneStyle : Health & Beauty Management Service www.hellogene.com/kor/genestyle

Hair thicknessHair lossPigmentation Vitamin C concentration

Skin elasticitySkin aging

BMI (Body Mass Index)

Cholesterol Caffeine metabolism

Triglyceride concentration

Blood sugar Blood pressure

GeneStyle Fitness Inspect genetic characteristics that affect body shape management and suggest individual customized body shape management and health management methods.

GeneStyle Inner Health Identify the genetic characteristics that affect the inside of the body and provide optimal healthcare solutions.

GeneStyle Outfit Beauty Care

Identify genetic characteristics that affect appearance and provide optimal beauty care solutions.

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THERAGEN ETEX_Genomic innovations, Healthcare solutions 14

Melaphy mist

Melaphy mist is a mist that you can feel the healing effect of a natural forest bath due to the

combination of cypress phytoncide and hydrogen. ou not only have an immediate moisture supply,

but also feel stress relief, skin relaxation, skin whitening, and can use it without irritation due to a

natural surfactant ingredient.

Melaphy mask

Melaphy mask is a highly moisturizing mask pack with unique phytoncide flavor. It is excellent

for sensitive skin care and has a trouble calming effect. It is a mask pack that you can feel skin

radiance just by using it once.

Melaphy Line

GeneStyle Skin GeneStyle Skin is a program that provides individual customized cosmetic solutions combining cosmetic ingredients that match the skin characteristics of an individual by identifying individual genetic information of the skin. As the close relationship between genetic characteristics and aging has been confirmed, interest in individual customized management is increasing. We conduct anti-aging management considering the genetic characteristics of individual through DNA analysis.

Gene Re uvenating Line

Genetic information provided by GeneStyle skin

Rejuvenating skin toner

Fermented filtrate 82 concentrate, which is produced when an alcohol is made in a brewery, supplies moisture to skin, and gives the effect of a natural exfoliator and thus makes your skin transparent and clear.

Gene rejuvenation skin serum

Customized, highly concentrated, functional serum that provides an optimized solution for skin DNA.

Gene rejuvenation skin cream

If you do not want to miss the moisture lost in your skin, you need silk protein. As it contains a large amount of silk protein that moisturizes skin for a long time.

ELASTICIT SUN DAMAGE

WRINKLE

FREE RADICAL DAMAGE

PIGMENTATION

SENSITIVIT INFLANMATION

GENEST LESKIN

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15 THERAGEN ETEX_Genomic innovations, Healthcare solutions

08 Subsidiary Company

MedPacto is a specialized company that develops anticancer medicine. TEW-7197, an anticancer drug for oral use, acts on TGF-beta receptor kinase type 1, received IND approval from US FDA, and has demonstrated safety and effectiveness based on the results of several studies.

01 MedPacto Development of new anticancer drugs

www.medpacto.com

02 NIPT (Non-invasive Prenatal Test) Service

GenomeCare is a gene test specialized company for before childbirth and implantation and aims to contribute to the welfare of mankind through safe birth by discovering gene mutation that causes infertility and pregnancy difficulty through NGS technology for women who are pregnant or planning pregnancy.

03 Leadpharm Professional Drug Distribution

www.leadpharm.com

LeadPharm, centered on the pharmacy chain business, supplies pharma-ceuticals to hospitals and pharmacies. It provides the best products that are competitive and differentiated and doing its best to create values by actively supporting member companies. LeadPharm is constantly making efforts with a sense of vocation for the healthy life of mankind.

04 Theragen HealthCare Medical Supplies Manufacturing and Distribution

Theragen Healthcare and Daeil Pharmaceutical have been researching and developing various diabetic products in the era of about 5 million people with diabetes and have been distributing them to pharmacies and health-care shops. In addition, we are developing a variety of products in the healthcare field and advancing to be a responsible company with the goal of improving the quality of human life.

Etex Pharmaceutical, founded in 1990, is a specialized company for manu-facturing first generic and improved drugs. We do stable and highly reliable drug production and quality control through KGMP facility. We produce 200 kinds of drugs and have fast and efficient sales and distribution system through 9 branches nationwide.

07 Etex Pharmaceutical Manufacture and Sale of Medicine www.etexpharm.com

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THERAGEN ETEX_Genomic innovations, Healthcare solutions 16

II Research and Resources 01 Research Results

Collaborative Research and Development Projects with Several Excellent Universities and Hospitals

National Research Projects or R&D Projects with Other Companies

- Ongoing collaborative research with many excellent universities and hospitals (R&D)- Lung cancer research in Oncology Internal Medicine of Seoul National University Hospital- Joint research of lung cancer and stomach cancer research with National Cancer Center- Cancer research in Oncology Internal Medicine of Shinchon Severance Hospital- Korean skin marker research with Dermatology of Chungnam National University Hospital and LG Healthcare- Joint research on the analysis of cloned dog genome with Veterinary Science Department of Seoul National University

A study on early diagnosis through the discovery of gastric cancer target gene group unique in Koreans

(Genome Research, July 23, 2013)

Decoding the Minke whale genome for the first time in the world

(Nature Genetics, June 18, 2013)

Release of world's first tiger genome map

(Nature Communication, May 2, 2013)

- Under development of Hellogene Skin with AMOREPACIFIC- Joint research on genome of the bat with School of Veterinary, Seoul National University - Research on the development of breeding with Nongwoo Bio - Agreement on an NIPT project with SCL - -Conducted industrial source technology development project, "Research and Commer-cialization of Genome using Next-generation Bioinformation", of the Ministry of Commerce, Industry and Energy (2011-2016)- Carried out "Decoding the Genome and RNA of the Whale Leading and Analyzing the Bioinformation" task of the Ministry of Maritime Affairs and Fisheries (2011-2013)- Completion of the world's first whale leading genome decoding and publication of research results in the world renowned academic journal (2014.11)- Korean genome analysis project of the Ministry of Health & Welfare, Exome sequencing data production for identifying genetic factors of obesity in adolescents (2013)- Performed post-genome multi-ministry genome project of the Ministry of Food, Agriculture and Forestry and Fisheries and Rural Development Administration (2014-2018) - Conducted a study on detoxification of shiitake mushroom genome with Chungbuk National University- Genome analysis of transgenic cow of veterinary corps of Seoul National University- Participated in genomic information construction project using Korean gene chip

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03 Equipment Status

04 Server Resources

THERAGEN ETEX_Genomic innovations, Healthcare solutions 18

uantStudio

Existing decoder held by Theragen

BeadXpress

Ion PGM sequencer Ion Proton sequencer GeneTitan LC480

Fluidigm

MicroarrayNext generation base sequence

HiSeq4000 HiSeq2500Novaseq 6000

Bioinformatics Computer Server

Over CPU 5,000 CoreFast and reliable storage and calculation of data

BioinformaticsStorage Servers

Over 5 PB Storage Rapid and reliable storage and backup of data

Emergency Power Equipment

40KW UPSMinimize server downtime and ensure safety during power failure

Bioinformaticseb servers

Over 350 Servers

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19 THERAGEN ETEX_Genomic innovations, Healthcare solutions

05 Appreciation (1) – Government-Approved Best uality

06 Certification Program : Certified Service Provider

Certificate of Gene Inspection AccuracyOnly company in Korea to

receive the highest grade certification for genetic testing accuracy

evaluation for four consecutive years

Technical patent certificateHolds a large number

of patents for managing developed technologies as a result

of research

ISO9001 certificationObtained international certification of accurate quality management system for services

Illumina service provider

Agilent service provider

Affymetrix service provider

Life technologies service provider

The certification program is a quality verification program for a variety of genome analysis platforms, including genome decoding equipment and library kits. Customers can trust our services because consistent service with the best quality can be provided.

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07 Ma or History

THERAGEN ETEX_Genomic innovations, Healthcare solutions 20

201612 Analysis automation report service conducted genome-report

09 Launched HelloGene I, a HelloGene derivative product

06 Launch of GeneStyle (health & beauty care service)

05 Selected as a job excellent company in Gyeonggi-do

05 Launch of BRCAinside service, a gene test of breast cancer / ovarian cancer

201705 Introduction of Illumina NovaSeq

03 NGS laboratory certification

02 4 consecutive years of highest grade certification for the genetic testing accuracy evaluation

08 HelloGene, personal genetic information services, sales contract with uhan Corporation

05 Next-generation genome cancer genome analysis platform development(Oncomics)

01 Next-generation genome mass analysis platform development(Xomics)

12 Established a local corporation in China for entering into the Chinese market and for joint ventures

03 03 Concluded partnership with Australian Skin DNA to Enhance skin DNA analysis and personalized consulting services

2009 Leading participation in Pan-Asian Genetic Diversity Study Consortium(Science, 2009)

2008 Participated in Korean Genome Project(Genome Research 2009

11 ISO9001 2008 certification of Bio Research Center( uality management systems)

04 Published "Discovery of Diffuse Gastric Cancer-inducing Mutation Gene" with the National Cancer Center

in Genome Biology

01 HelloGene services started clinical studies with 18 general hospitals

01 Completed the world's first decryption of whale genome and published research results in the journal Nature Genetics

11 Launch of the Asia's first personal genome analysis service, "HelloGene" for the first time in Chinese travelers.

10 The Worlds first Cloned Dog, Snuppy Genome Analysis completion and publication of the research results

in the world journal, Nature

09 The World s first completion of Korean Tiger Genome Project and publication of the research results in the journal,

Nature Communications

06 The Korea s first decoding of Korean Gastric Cancer Gene Mutation and publication of the research results in the

journal, Genome Research

01 Selected as a partner company for industry-university cooperation of Dankook University Sequencing Center

10 Construction of Asian Genome Project(Pan-Asian SNP) Consortium 2.0

09 Completed KT joint project (Full length genome decryption and analysis of 20 Koreans)

08 Selected as a joint research institution for whale genome project of Korea Ocean Research and

Development Institute

07 Selected as an industry source for technological development by the Ministry of Knowledge Economy

12 Launch the Korea s first Korean Personal Genome Project(KPGP)

10 The World s first Tiger Genome Decode and Analysis(Completed in 2011)

05 The World s first Native Soybean Analysis

04 The World s first released Female Genome Decode and Analysis(Rosalynn Gill)

03 Completed "Korean Cow Genetic Map" jointly with Rural Development Administration

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A d d r e s s 경기도 수원시 영통구 광교로 145 차세대융합기술원 A동 4층 (16229) TEL 1 5 2 2 - 2 3 8 2Homepage w w w . t h e r a g e n e t e x . c o m E-mail b i o @ t h e r a g e n e t e x . c o m

THERAGEN ETEX


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