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Consequence
Market trends
Shift in port folio
Seamless transfer R&D to manufacturing
Drug release based on in-life testing
Shift in business strategy
Shift in channels
Shift in region
Healthcare system
Predictive
Blood testing
Healthcare cards
Preventive
Wellness
Nutrician
Personalized
Combination therapy(drug, diagnostic, delivery)
Compliance monitoring
Participatory Shake up of the market
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Flow
Think of rocks and boulders as “waste” because they slow down the water flow. Lean is focused on eliminating these barriers so that water (or process) can flow smoothly without interruptions.
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Establishing Siemens as the Leading Industry Software Provider
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Choices on business strategy
Increase operating efficiency
Increase flexibility
Reduce product costs / achieve competitive pricing
Produce individual products / address niche markets
Accelerate time-to-market
Shift in business strategy
Raise ceiling
Innovate Conti, RTPR, JIT
Raise floor
Modernize within existing facility
Scout
Data Integration Integrated PLM
Large scale
flexible, high throughput
Small scale
Flexible , 24/7 (integration R&D)
Own Production Outsourcing
Requirements
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Modernize
Modernize
Increase Level of Automation
Extend the IT (MES)
Quality by design
Advanced Process Control
….
Production logistics
Utilities
….
Shift in business strategy
Raise ceiling
Conti, Single s, RTPR, JIT
Raise floor
Modernize within existing facility
Scout
Data Integration Integrated PLM
Large scale
flexible, high throughput
Small scale
Flexible , 24/7 (integration R&D)
Own Production Outsourcing
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•ERP
Automation approach
•Unit A •Unit Y •Unit Z•Unit B
MES
Central Operation
MES
Central Operation
The multidisciplinairy approach
Multidisciplinairy approach
In-line Process TestingIn-line Process Testing
Building M
anagement S
ystemB
uilding Managem
ent System
PATPAT
Tracking & TracingTracking & Tracing
LIMSLIMS
PLMPLM
GMP
Process Instrumentation
Process Instrumentation
Control(DCS / PLC)
Control(DCS / PLC) PATPAT
Process development
Process developmentScada / HMIScada / HMI
MESMES
Engineering
Integrateddesign tools
Integrateddesign tools
PLMPLM
ElectricalElectricalMotion control
Motion control
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Innovate
Choised on business strategy
Single use
Continuous manufacturing
Micro processing
Modularize (plug & play)
…
Supply chain improvement
Shift in business strategy
Raise ceiling
Conti, Single s, RTPR, JIT
Raise floor
Modernize within existing facility
Scout
Data Integration Integrated PLM
Large scale
flexible, high throughput
Small scale
Flexible , 24/7 (integration R&D)
OwnProduction Outsourcing
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Scouting
Scouting the future
Closing the gap between manufacturing & R&D
Integrated product & production Life Cycle Management
…
Shift in business strategy
Raise ceiling
Conti, Single s, RTPR, JIT
Raise floor
Modernize within existing facility
Scout
Data Integration Integrated PLM
Large scale
flexible, high throughput
Small scale
Flexible , 24/7 (integration R&D)
OwnProduction Outsourcing
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Production life cycle
Production life cycle
Design Engineering
In-stallation
Ope-ration
Main-tenance
Modern-isation
End of life cycle
Effort
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Integrated Production Lifecycle Management, Automation Engineering & Maintenance
Plant Life Cycle
Engineering Installation &Commissioning
Operation MaintenanceDesign Modernization& Upgrade
•PROFIBUS
•AS
•ES •OSDCS
Digital Engineering
Process Control System
Asset Management
Maintenance
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Manufacturing unitProduction Lifecycle Management
Integrated Production Lifecycle Management
Automationdesign
Production
Industrial Automation
Industrial Power
Factory design
Product design
•PLM
Digital Factory
CAM
CAE
CAD
•Digital collaboration
•Production •Lifecycle Management
Automationsystems
CommunicationDrive systems
Sensors and analyticsManufacturing Execution Systems
Low-voltage control and power supply
Functional automation engineeringPLC programming
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Benefits Integrated Production Lifecycle
Integrated Production Lifecycle Management
Factory design
Product design
•PLM
Digital Factory
CAM
CAE
CAD
•Digital collaboration
•Production •Lifecycle Management
Reduces engineering costs byCommon engineering based on standardized data exchangeSingle data input and one-time engineering for common dataReusable engineering units
Reduces plant operation costs byHolistic asset management in one central application Mutual shutdown and commissioning planning
Reduces modernization/upgrade costs byConsistent and complete as-built plant documentationStandardized exchange formats allowing modernization without automation know-howHomogeneous databases with access to all plant-relevant data
Production Lifecycle Management
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Integration Production Lifecycle in Product Lifecyc le
Product life cycle
Effort
LeadDevelop.
Pre-clinicalEvaluation
Phase I Phase II Phase III Sub-mission
DiscoveryScreaning
Phase IV
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Shift in Product Lifecycle
Product life cycle
Effort
MoleculeDevelop-ment
Sub-mission
Patho –physiology
In life testing
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Data available all around
Closing the GapData all around
Data PortalData Portal
MESMES
LabLab PilotPilotDCS / PLCDCS / PLC
ERPERP
Knowledge systemsKnowledge systems
PLMPLM
LIMSLIMS
R&D Manufacturing
PATPAT BatchBatch
Clinical trialsClinical trials
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Integration of (R&)D and Manufacturing
Closing the gapShift in business strategyIllu'sPharma_Pagina_06
Data PortalData Portal
MESMES
LabLab PilotPilotDCS / PLCDCS / PLC
ERPERP
Knowledge systemsKnowledge systems
PLMPLM
LIMSLIMS
PATPAT BatchBatch
Clinical trialsClinical trials
R&D Manufacturing
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Considering the Value Across the Entire Product Lifecycle…
Process design
Process plan
Process simulations
Plant/line simulations
Human simulations
Packaging
programs & simulations
Virtual commissioning
Quality data
Production
Product requirements
Product concepts
Product alternatives
Product revision
Product simulations
Product specs
Material specs
Engineering BOM
Manufacturing BOM
In-service BOM
Engineering Change Requests
Product
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•How do we turn more ideasinto successful products?
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Customer values being realized by a seamless Product and Production Life Cycle
2
3
1Engineering
Customer
Production
New Product Requirements
Production Design
Simulation
Commissioning
Operation
Optimization, Maintenance
Product Use
Product Service
Product Design
By transforming your process of innovation
BUILD THE RIGHT PRODUCT
BUILD THE PRODUCT RIGHT
AND
Integrated PLM
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Customer values being realized by a seamless Product and Production Life Cycle
2
3
1Engineering
Customer
Production
New Product Requirements
Production Design
Simulation
Commissioning
Operation
Optimization, Maintenance
Product Use
Product Service
Product Design
BUILD THE RIGHT PRODUCT1. Timing
2. Function
3. Performance
4. Price
BUILD THE PRODUCT RIGHT
1. Cost
2. Quality
3. Quantity
4. Reliability
5. Availability
6. Sustainability
Integrated PLM
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Customer values being realized by a seamless Product and Production Life Cycle
BEFORE
Product and production lifecycles disconnected and
misaligned with unstructured feedback.
AFTER
Product and production lifecycles joint and aligned
in closed-loop disciplines.
“…innovations often happen at the intersection of disciplines”
(Lakhani & Jeppesen, Harvard Business Review, 2007)
2
3
1Engineering
Customer
Production
New Product Requirements
Production Design
Simulation
Commissioning
Operation
Optimization, Maintenance
Product Use
Product Service
Product Design
Integrated PLMResult
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Introduction of PLM Solutions requires a wide support and good preparation
People
Process
TechnologyImplementation
Management & Technical staff
Specialists
Organisational consequences &Process change management
Maintenance & Support
Expert services
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Why are we not using the options
Shift in business strategy
Raise ceiling
Innovate Conti, RTPR, JIT
Raise floor
Modernize within existing facility
Scout
Data Integration Integrated PLM
Large scale
flexible, high throughput
Small scale
Flexible , 24/7 (integration R&D)
Own Production Outsourcing
Requirements
Priorities
Wrong people
Wrong story
Wrong time
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Tomorrow’s focus must be on complexity management, not simply complexity reduction.”
•“
The Complexity ChallengeA.T. Kearney
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Thank You!
Jelle Zijlstra, Branche Manager Life Sciences
Siemens Netherlands+31 (0)6 531 544 [email protected]