Biomedicine. springer.com/NEWSonline 14 F. Borruto, University of Verona, Italy; M. De Ridder, Free University of Brussels, Belgium (Eds) HPV and Cervical Cancer Achievements in Prevention and Future Prospects is book is meant to provide a complete over- view of the research of HPV and its connection to cervical cancer. Features 7 Provides overview of HPV research from discovery to the present day 7 Examines the process of HPV infection to oncogenesis 7 Ex- plores the effects of HPV vaccination Contents Preface.- e epidemiology of cervical cancer.- Human Papillomavirus And Cervical Cancer: Overview.- Prevention of HPV Associated Diseases in the United States.- Immunogenicity and efficacy of, and most effective and just imple- mentation strategies for human papillomavirus vaccines – an overview.- e Immunobiology Of Human Papillomavirus Associated Oncogenesis.- HPV and erapeutic Vaccines: Where are we in 2010?.- Infection and cervical cancer: an old fact with a recent solution.- Colposcopic Appearance Of Hpv Infection.- Index. Fields of interests Cancer Research; Pharmacology/Toxicology Target groups Research Product category Contributed volume Due February 2012 2012. X, 200 p. Hardcover 7 approx. € 139,95 | £126.50 7 approx. * € (D) 149,75 | € (A) 153,94 | sFr 186,50 ISBN 978-1-4614-1987-7 9<HTMERB=ebjihh> T. J. Cleophas, A. H. Zwinderman, European Interuniversity College Pharmaceutical Medicine, Lyon, France Statistics Applied to Clinical Studies Contents Preface. Foreword.-1 Hypotheses, data, strati- fication.-2 e analysis of efficacy data.-3 e analyis of safety data.-4 Log likelihood ratio tests for safety data analysis.-5 Equivalence testing.- 6 Statistical power and sample size.-7 Interim analyses.-8 Clinical trials are oſten false positive.-9 Multiple statistical inferences.-10 e interpreta- tion of the p-values.-11 Research data closer to expectation than compatible with random sam- pling.-12 Statistical tables for testing data closer to expectation than compatible with random sam- pling.-13 Dispersion issues.-14 Linear regression, basic approach.-15 Linear regression for assessing precision, confounding, interaction, basic ap- proach.-16 Curvilinear regression.-17 Logistic and cox regression, markow models, regression with laplace transformations.-18 Regression modeling for improved precision.-19 Post-hoc analysis in clinical trials, a case for logistic regression analy- sis.-20 Multistage regression.-21 Categorical data.- 22 Missing data.-23 Poisson regression for event analysis.-24 More on non linear relationships, splines.-25 Multivariate modeling.-26 Bhattacha- rya modeling.-27 Trend-testing.-28 Confound- ing.-29 Propensity score matching.-30 Interac- tion.-31 Time-dependent factor analysis.-32 Meta-analysis, basic approach.-33 Meta-analysis, review and update ofmethodologies.-34 Meta- regression.-35 Crossover studies with continu- ous variables.-36 Crossover studies with binary responses.-37 Cross-over trials should not be used to test treatments with different chemical class.-38 Quality-of-life assessments in clinical. [...] Fields of interests Biomedicine general; Laboratory Medicine; Statis- tics, general Target groups Research Product category Monograph Due February 2012 5th ed. 2012. XXVI, 743 p. 178 illus., 44 in color. Hardcover 7 approx. € 169,95 | £153.00 7 approx. * € (D) 181,85 | € (A) 186,94 | sFr 226,50 ISBN 978-94-007-2862-2 9<HTUELA=hcigcc> A. Destexhe, M. Rudolph-Lilith, CNRS, Gif sur Yvette, France Neuronal Noise Neuronal Noise combines experimental, theoreti- cal and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations. e book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise. Features 7 Neuronal Noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity 7 e book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise 7 Provides students and young research- ers with an overview of the important methods and concepts that have emerged from research in this area 7 e book covers many aspects of noise in neurons, with an emphasis on the larg- est source of noise: synaptic noise 7 Provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area 7 Provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area Contents 1 Introduction.- 2 Basics.- 3 Synaptic noise.- 4 Models of synaptic noise.- 5 Integrative properties in the presence of noise6 Recreating synaptic noise using dynamic-clamp.- 7 e mathematics of syn- aptic noise.- 8 Analyzing synaptic noise.- 9 Case studies.- 10 Conclusions and perspectives A Nu- merical integration of stochastic differential equa- tions.- B Distributed Generator Algorithm.- C e Fokker-Planck formalism.- D e RT-NEURON interface for dynamic-clamp.- References.- Index. Fields of interests Neurosciences; Neurobiology Target groups Research Product category Monograph Due January 2012 2012. XVIII, 462 p. 203 illus., 1 in color. (Springer Series in Computational Neuroscience, Volume 8) Hardcover 7 € 149,95 | £135.00 7 * € (D) 160,45 | € (A) 164,94 | sFr 200,00 ISBN 978-0-387-79019-0 9<HTLDTH=hjabja>
Transcript
Biomedicine. springer.com/NEWSonline
14
F. Borruto, University of Verona, Italy; M. De Ridder, Free University of Brussels, Belgium (Eds)
HPV and Cervical CancerAchievements in Prevention and Future Prospects
This book is meant to provide a complete over-view of the research of HPV and its connection to cervical cancer.
Features 7 Provides overview of HPV research from discovery to the present day 7 Examines the process of HPV infection to oncogenesis 7 Ex-plores the effects of HPV vaccination
Contents Preface.- The epidemiology of cervical cancer.- Human Papillomavirus And Cervical Cancer: Overview.- Prevention of HPV Associated Diseases in the United States.- Immunogenicity and efficacy of, and most effective and just imple-mentation strategies for human papillomavirus vaccines – an overview.- The Immunobiology Of Human Papillomavirus Associated Oncogenesis.- HPV and Therapeutic Vaccines: Where are we in 2010?.- Infection and cervical cancer: an old fact with a recent solution.- Colposcopic Appearance Of Hpv Infection.- Index.
Fields of interestsCancer Research; Pharmacology/Toxicology
T. J. Cleophas, A. H. Zwinderman, European Interuniversity College Pharmaceutical Medicine, Lyon, France
Statistics Applied to Clinical StudiesContents Preface. Foreword.-1 Hypotheses, data, strati-fication.-2 The analysis of efficacy data.-3 The analyis of safety data.-4 Log likelihood ratio tests for safety data analysis.-5 Equivalence testing.- 6 Statistical power and sample size.-7 Interim analyses.-8 Clinical trials are often false positive.-9 Multiple statistical inferences.-10 The interpreta-tion of the p-values.-11 Research data closer to expectation than compatible with random sam-pling.-12 Statistical tables for testing data closer to expectation than compatible with random sam-pling.-13 Dispersion issues.-14 Linear regression, basic approach.-15 Linear regression for assessing precision, confounding, interaction, basic ap-proach.-16 Curvilinear regression.-17 Logistic and cox regression, markow models, regression with laplace transformations.-18 Regression modeling for improved precision.-19 Post-hoc analysis in clinical trials, a case for logistic regression analy-sis.-20 Multistage regression.-21 Categorical data.-22 Missing data.-23 Poisson regression for event analysis.-24 More on non linear relationships, splines.-25 Multivariate modeling.-26 Bhattacha-rya modeling.-27 Trend-testing.-28 Confound-ing.-29 Propensity score matching.-30 Interac-tion.-31 Time-dependent factor analysis.-32 Meta-analysis, basic approach.-33 Meta-analysis, review and update ofmethodologies.-34 Meta-regression.-35 Crossover studies with continu-ous variables.-36 Crossover studies with binary responses.-37 Cross-over trials should not be used to test treatments with different chemical class.-38 Quality-of-life assessments in clinical. [...]
Fields of interestsBiomedicine general; Laboratory Medicine; Statis-tics, general
A. Destexhe, M. Rudolph-Lilith, CNRS, Gif sur Yvette, France
Neuronal NoiseNeuronal Noise combines experimental, theoreti-cal and computational results to show how noise is inherent to neuronal activity, and how noise can be important for neuronal computations. The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise.
Features 7 Neuronal Noise combines experimental, theoretical and computational results to show how noise is inherent to neuronal activity 7 The book covers many aspects of noise in neurons, with an emphasis on the largest source of noise: synaptic noise 7 Provides students and young research-ers with an overview of the important methods and concepts that have emerged from research in this area 7 The book covers many aspects of noise in neurons, with an emphasis on the larg-est source of noise: synaptic noise 7 Provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area 7 Provides students and young researchers with an overview of the important methods and concepts that have emerged from research in this area
Contents 1 Introduction.- 2 Basics.- 3 Synaptic noise.- 4 Models of synaptic noise.- 5 Integrative properties in the presence of noise6 Recreating synaptic noise using dynamic-clamp.- 7 The mathematics of syn-aptic noise.- 8 Analyzing synaptic noise.- 9 Case studies.- 10 Conclusions and perspectives A Nu-merical integration of stochastic differential equa-tions.- B Distributed Generator Algorithm.- C The Fokker-Planck formalism.- D The RT-NEURON interface for dynamic-clamp.- References.- Index.
Fields of interestsNeurosciences; Neurobiology
Target groupsResearch
Product categoryMonograph
Due January 2012
2012. XVIII, 462 p. 203 illus., 1 in color. (Springer Series in Computational Neuroscience, Volume 8) Hardcover7 € 149,95 | £135.007 * € (D) 160,45 | € (A) 164,94 | sFr 200,00ISBN 978-0-387-79019-0
K. Groschner, Karl Frazens University, Graz, Austria; W. F. Graier, Medical University, Graz, Austria; C. Romanin, Linz, Austria (Eds)
Store-operated Ca2+ entry (SOCE) pathwaysEmerging signaling concepts in human (patho)physiology
Contents Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE – Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous mes-sengers and mediators (V. M. Bolotina).- SEC-TION 2: SOCE – Crosstalk between organelle and cellular compartments.- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribution of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. [...]
Fields of interestsMolecular Medicine; Cell Biology; Human Physi-ology
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XII, 500 p. 56 illus., 32 in color. With online files/update. Hardcover7 € 149,95 | £135.007 * € (D) 160,45 | € (A) 164,94 | sFr 200,00ISBN 978-3-7091-0961-8
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M. Hayat, Kean University, NJ, USA (Ed.)
Stem Cells and Cancer Stem Cells, Volume 4Therapeutic Applications in Disease and Injury
Contents I. Molecular genetic.-1 Neural stem/progeni-tor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins.-2 Sensitivity of hematopoietic and leukemic stem cells to hoxa gene levels.-3. Maintenance of neural stem cells in the brain: role of notch signaling.-4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger.-5 Differentia-tion of periodontal stem/progenitor cells: roles of tgf-β1.-6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness.-7 Smooth muscle cell differentiation from embryonic stem cells: role of hdac7 and pdgf-bb.-8 Adult neural stem cells; identity and regulation. II. Regenerative Medicine.-9 Tendon injury: role of differentiation of aduilt and embryonic derived stem cells.-10 The potential of stem cells and tissue engineered scaf-folds for repair of the central nervous system.-11 Improving the efficacy of diabetes mellitus treat-ment by combining cell replacement therapy with immune correction.-12 Induced pluripotent stem cell production and characterization: an overview of somatic cell reprogramming.-13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins.-14 Pluripo-tent cell-derived glial precursor cells for the deliv-ery of therapeutic proteins to the central nervous system.-15 Cellularized scaffolds: new clothes for cardiac regenerative medicine.-16 Microencap-sulation procedures for the immunoisolation of wharton’s jelly mesenchymal stem cells: a review. III Therapy. [...]
Fields of interestsCancer Research; Oncology; Stem Cells
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XII, 366 p. 44 illus., 32 in color. (Stem Cells and Cancer Stem Cells, Volume 4) Hardcover7 € 149,95 | £135.007 * € (D) 160,45 | € (A) 164,94 | sFr 200,00ISBN 978-94-007-2827-1
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M. Hayat, Kean University, NJ, USA (Ed.)
Tumors of the Central Nervous System, Volume 6Spinal Tumors (Part 1)
Contents 1 General introduction.-2 Pediatric mixed glio-neuronal tumors in the spinal cord.-3 Intradural spinal tumors: classification, symptoms, and radio-logical features.-4 Non-dysraphic intradural spinal cord lipoma: management guidelines.-5 Malignant astrocytomas of the spinal cord: clinicopathologic parameters.-6 Spinal epidural angiolipoma. I Di-agnosis.-7 Spinal cord tumor oligodendroglioma: diagnosis.-8 Primary spinal oligodendroglioma: diagnosis, outcome, and prognosis.-9 Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis.-10 Intraspinal oncocytic adrenocortical adenoma: diagnosis.-11 Chordomas of the clivus and upper cervical spine. Imaging.-12 Spinal teratoid/ rhabdoid tumor: use of diffusion - weighted imaging for diagnosis.-13 Gangliogliomas of the spinal cord: neuroimag-ing correlations with pathology, controversies in pathological diagnosis, and prognosis. Therapy.-14 Surgery for spinal tumours.-15 Resection of spinal meningioma: postoperative focal hyperemia.-16 Spinal cord hemangioblastomas: surgical manage-ment.-17 Spinal radiosurgery: delayed radiation-induced myelopathy.-18 Metastatic spine disease: indications, timing, and outcomes for surgery and radiation therapy.-19 Sequence of surgery, radiotherapy, and stereotactic radiosurgery in the treatment of metastatic spine disease: effects on wound healing.-20 Treatment of spinal tumors with cyberknife stereotactic radiotherapy.-21 Re-current spinal cord cystic astrocytomas: treatment with rhenium-186 intracavitary radiation.-22 Embolization of spinal tumors. [...]
Fields of interestsCancer Research; Laboratory Medicine; Diagnos-tic Radiology
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. XXXII, 204 p. 64 illus., 26 in color. (Tumors of the Central Nervous System, Volume 6) Hardcover7 € 139,95 | £126.007 * € (D) 149,75 | € (A) 153,94 | sFr 186,50ISBN 978-94-007-2865-3
M. v. Itzstein, Griffith University, QLD, Australia (Ed.)
Influenza Virus Sialidase - A Drug Discovery TargetInfluenza continues to be an ongoing problem de-spite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interac-tions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented.
Features 7 Covers all relevant aspects of anti-influenza virus drug discovery 7 Contributions by inter-national leading scientists 7 A valuable source of information for researchers, clinicians and the pharmaceutical industry
Contents Influenza Virus Virology.- Investigating the inter-action between influenza and sialic acid – making and breaking the link.- Enzymology of Influenza Virus Sialidase.- Influenza Virus Sialidase and Structure-Based Drug Design.- The Development of Carbohydrate-based Influenza Virus Sialidase Inhibitors.- The Development of Non-carbohy-drate-based Influenza Virus Sialidase Inhibitors.- Clinical Experience with Influenza Virus Sialidase Inhibitors.- Resistance Development to Influenza Virus Sialidase Inhibitors.
Fields of interestsPharmacology/Toxicology; Infectious Diseases; Virology
Target groupsResearch
Product categoryContributed volume
Available
2012. IX, 178 p. 58 illus., 21 in color. (Milestones in Drug Therapy) Hardcover7 € 139,95 | £126.007 * € (D) 149,75 | € (A) 153,94 | sFr 186,50ISBN 978-3-7643-8926-0
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Y. Karamanos, Université d‘Artois, Arras, France (Ed.)
Expression Profiling in NeuroscienceFeatures 7 Provides the most commonly used approaches to gene and protein expression profiling in the field of neuroscience 7 Examines the techniques in thorough detail in order to create lab-ready instruction 7 Features clear-cut advice and guid-ance from expert researchers in the field
Contents DNA Microarrays for Gene Expression Analysis in Brain Tissue and Cell Lines.- Gene Expres-sion Profiling Using the Terminal Continuation (TC) RNA Amplification Method for Small Input Samples in Neuroscience.- Expression Profiling In Brain Disorders.- Endothelial Cell Heteroge-neity of Blood-Brain Barrier Gene Expression: Analysis by LCM/qRT-PCR.- Gene Expression Profiling Using 3’ Digital Tag Approach.- Sharing Expression Profiling Data with Gemma.- Two-Dimensional Protein Analysis of Neural Stem Cells.- iTRAQ Proteomics Profiling of Regulatory Proteins During Oligodendrocyte Differentia-tion.- Protein Profiling of the Brain: Proteomics of Isolated Tissues and Cells.- The Proteome of Brain Capillary Endothelial Cells: Towards a Molecu-lar Characterization of an In Vitro Blood-Brain Barrier Model.- MALDI Imaging Technology Application in Neurosciences: From History to Perspectives.- Profiling of HIV Proteins in Cere-brospinal Fluid.- Proteomic Profiling of Cerebro-spinal Fluid.- New Nanotechnology Applications in Single Cell Analysis: Why and How.
Fibrinolytic Bacterial Enzymes with Thrombolytic ActivityStress, high blood pressure, smoking, pollu-tion, fast foods, overweight, excessive travelling, surgery, less movement are common features in our modern life. These features are risky for blood clotting disorders. According to WHO, over 29% of the total mortalities worldwide are due to thrombosis. By the year, 2020 cardiovascular dis-eases (CVDs) may cause an estimated 25 million deaths per year, thus antithrombotic therapy is of great interest. The available thrombolytic agents such as urokinase are highly expensive, antigenic, quite unspecific, pyretogenic and hemorrhagenic. Therefore, the production of fibrinolysing en-zymes, which rapidly dissolute thrombi within the vascular tree, without the detriments by microor-ganisms, as described in this book, is the desirable aim of today’s research.
Features 7 Integrated practical and theoretical trends 7 Describes fibrinolytic microbial enzymes for clinical applications 7 Provides an outlook to future research
Fields of interestsMedical Microbiology; Hematology; Cardiology
Target groupsResearch
Product categoryBrief
Due December 2011
2012. XI, 97 p. 15 illus., 6 in color. (SpringerBriefs in Microbiology) Softcover7 € 49,95 | £44.997 * € (D) 53,45 | € (A) 54,95 | sFr 66,50ISBN 978-3-642-24979-2
M. R. Kreutz, Leibniz Institute for Neurobiology, Magdeburg, Germany; C. Sala, Consiglio Nazionale delle Richerche, Milano, Italy (Eds)
Synaptic PlasticityDynamics, Development and Disease
Contents Preface Michael R. Kreutz, Carlo Sala.- Molecular organization of the pre- and postsynaptic scaffold: 1. Uli Thomas, Stephan Sigrist: Glutamate recep-tors in synaptic assembly and plasticity – case studies on fly NMJs.- 2. Chiara Verpelli, Michael J. Schmeisser, Carlo Sala, Tobias M. Boeckers: Scaffold proteins at the Postsynaptic Density.- 3. Laurent Fagni: Diversity of metabotropic gluta-mate receptor interacting proteins and patho-physiological functions.- 4. Peter Penzes, Igor Rafalovich: Regulation of the actin cytoskeleton in dendritic spines.- 5. Olena Bukalo, Alexander Dityatev: Synaptic cell adhesion molecules.- Mo-lecular dynamics of the synapse: 6. Shigeo Okabe: Molecular dynamics of excitatory synapses.- 7. Renato Frischknecht, Eckart D. Gundelfinger: The brain’s extracellular matrix and its role in synaptic plasticity.- 8. Robert van den Berg, Casper C. Hoogenraad: Molecular motors in cargo traf-ficking and synapse assembly.- 9. Martin Heine: Surface traffic in synaptic membranes.- 10. Bong-Kiun Kaang, Jun-Hyeok Choi: Synaptic protein degradation in memory reorganization.- 11. Mad-hav Sukumaran, Andrew C. Penn, Ingo H. Greger: AMPA receptor assembly – atomic determinants and built-in modulators.- 12. Malgorzata Urban-ska, Lukasz Swiech, Jacek Jaworski: Developmental plasticity of the dendritic compartment: focus on the cytoskeleton.- 13. Stefan Kindler, Hans-Jürgen Kreienkamp: Dendritic mRNA targeting and translation.- 14. Mirko Santello, Corrado Calì, Paola Bezzi: Gliotransmission and the Tripartite Synapse. [...]
Fields of interestsNeurosciences; Neurology; Neurobiology
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. Approx. 600 p. 120 illus., 20 in color. (Advances in Experimental Medicine and Biology, Volume 970) Hardcover7 € 169,95 | £153.007 * € (D) 181,85 | € (A) 186,94 | sFr 226,50ISBN 978-3-7091-0931-1
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Z. D. Luo, University of California Irvine Medical Center, Orange, CA, USA (Ed.)
Pain ResearchMethods and Protocols
Contents Advancements in Pain Research.- Genomic Methods for Clinical and Translational Pain Research.- Two-Dimensional Gel Electropho-resis: Discovering Neuropathic Pain-Associated Synaptic Biomarkers in Spinal Cord Dorsal Horn.- Whole-Cell Patch-Clamp Recordings on Spinal Cord Slices.- Whole-Cell Recording in Isolated Primary Sensory Neurons.- Indwelling Supradu-ral Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing.- An Experimen-tal Model of Headache-Related Pain.- A Rodent Model of Trigeminal Neuralgia.- New Models of Experimental Parotitis and Parotid Gland Distension in Rats.- A Rat Pain Model of Facial Cancer.- Orofacial Pain Models and Behavior Assessment.- Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain.- A Lumbosacral Ventral Root Avulsion Injury and Repair Model for Studies of Neuropathic Pain in Rats.- A Rat Chronic Pain Model of Spinal Cord Contusion Injury.- The Spared Nerve Injury Model of Neuropathic Pain.- A New Rat Pain Model of Thrombus-Induced Ischemia.- Rat Models of Pancreatitis Pain.- The Monosodium Iodoacetate Model of Osteoarthritis Pain in The Rat.- K/BxN Serum Transfer Arthritis as a Model of Inflammatory Joint Pain.- A New Rat Model of Bone Cancer Pain.- Exposure of the Dorsal Root Ganglion to Pulsed Radiofrequency Current in a Neuropathic Pain Model of Periph-eral Nerve Injury.
Fields of interestsMolecular Medicine; Pain Medicine
A. Morozov, National Institutes of Health, Bethesda, MD, USA (Ed.)
Controlled Genetic ManipulationsThe current demand for the development of techniques for controlled genetic manipulations is driven by the anatomical and physiological com-plexity of the brain and by the need for experi-mental models that can address this complexity through selective manipulation of defined compo-nents of the system: specific neuronal populations or selected synapses.
Features 7 Provides both basic technical information and examples of creative implementation 7 Supplies readers with the details needed to bring these techniques to their own labs 7 Features key tips from the experts on how best to avoid common pitfalls
Contents Regulation of Cre Recombinase: Use of Ligand-Regulated and Dimerizable Cre for Transgenesis.- Genetic Manipulations Using Cre and Mutant loxP Sites.- Using Recombinant Adeno-Associated Viral Vectors for Gene Expression in the Brain.- Using Lentiviral Vectors as Delivery Vehicles for Gene Therapy.- Targeting Neurological Disease with siRNA.- In Utero Electroporation for Cel-lular Transgenesis in the Developing Mammalian Forebrain.- Single-Cell Electroporation of siRNA in Primary Neuronal Cultures.- Development and Application of Membrane-Tethered Toxins for Genetic Analyses of Neuronal Circuits.- Genetic Methods for Anatomical Analysis of Neuronal Circuits.- Functional Circuitry Analysis in Ro-dents Using Neurotoxins/Immunotoxins.- Analy-sis of Neuronal Circuits with Optogenetics.
J. Peccoud, Virginia Bioinformatics Institute, Blacksburg, VA, USA (Ed.)
Gene SynthesisMethods and Protocols
Features 7 Defines gene synthesis and determines what part of the process labs can do and what parts can be contracted to a specialized service pro-vider 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts
Contents Building Block Synthesis using the Polymerase Chain Assembly (PCA) Method.-Oligonucleotide Assembly in Yeast to Produce Synthetic DNA Fragments.-TopDown Real-Time Gene Synthesis.-De novo DNA Synthesis using Single-molecule PCR.-SLIC: A Method for Sequence and Ligation Independent Cloning.-Assembly of Standardized DNA Parts Using BioBrick Ends in E. coli.-Assem-bling DNA Fragments by USER Fusion.-Fusion PCR via Novel Overlap Sequences.-Using Recom-bineering to Generate Point Mutations: the Oligo-nucleotide-based “Hit & Fix” Method.-Using Recombineering to Generate Point Mutations: galK-Based Positive-Negative Selection Method.-Assembling Large DNA Segments in Yeast.-Recursive Construction of Perfect DNA Molecules and Libraries from Imperfect Oligonucleotides.-Cloning Whole Bacterial Genomes in Yeast.-Production of Infectious Poliovirus from Synthetic Viral Genomes.-In Silico Design of Functional DNA Constructs.-Using DNAWorks in Designing Oligonucleotides for PCR-Based Gene Synthesis.-De Novo Gene Synthesis Design Using TmPrime Software.-Design-A-Gene with GeneDesign.-Leading a Successful iGEM Team .-The Build-a-Genome Course.-DNA Synthesis Security.
Fields of interestsHuman Genetics; Genetic Engineering
2012. 1200 p. (In 2 volumes, not available separately)7 € 624,00 | £562.007 * € (D) 667,68 | € (A) 686,40 | sFr 831,00ISBN 978-1-4614-1998-3
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A. Prokop, Vanderbilt University, Nashville, TN, USA; S. Michelson, Genomic Health Inc, Redwood, CA, USA
Systems Biology in Biotech & PharmaA Changing Paradigm
Features 7 Numerous step-by-step tutorials help the read-er to learn quickly 7 Outline of key technologies and tools needed for the development of Systems Biology 7 Computational Systems Biology in Health and Disease 7 The use of Systems Biology for identifying drug targets
Contents Abstract.- 1 Introduction: Discovery & Development - New Facet Of Industry, New Tools And Lead Optimization: 1.1 Scope And Content Of This Review.- 2 Discovery: Use Of Systems Biology For Identifying Targets.- 3 Integrative Systems Biology I - Biochemistry: Phase I Lead Discovery & Molecular Interactions.- 4 Integrative Systems Biology Ii - Molecular Biol-ogy: Phase 2 Lead Discovery & In Silico Screening.- 5. Discovery: Computational Systems Biology (Csb) In Health & And Disease I.- 6 Development: In Vivo Pharmacology - Systems Biology In Health & Disease Ii.- 7 Devel-opment: Pharmacokinetics – Systems Biology In Health & Disease Iii.- 8 Development: Multiscale Csb – Simulation Tools.- 9 Develop-ment: Drug Formulation & Delivery.- 10 Development: Preclinical Model Based Drug Development.- 11 Systems Biology: Impact On Pharma And Biotech.- 12 Acknowledgment.- 13 Bibliography.
Fields of interestsBiomedicine general; Biotechnology; Applied Microbiology
Target groupsResearch
Product categoryBrief
Due December 2011
2012. XVI, 133 p. 16 illus. in color. (SpringerBriefs in Pharmaceutical Science & Drug Development) Softcover7 € 49,95 | £44.997 * € (D) 53,45 | € (A) 54,95 | sFr 66,50ISBN 978-94-007-2848-6
F. Rahimi, Australian National University, Canberra, ACT, Australia; G. Bitan, University of California at Los Angeles, CA, USA (Eds)
Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative DiseasesContents 1. Overview of Fibrillar and Oligomeric Assem-blies of Amyloidogenic Proteins.- 2. Pathologic Lesions in Alzheimer disease and Other Neuro-degenerative Diseases—Cellular and Molecular Components.- 3. Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins.- 4. Biological Target-ing and Activity of Pre-fibrillar Aβ Assem-blies.- 5. The Role of Aβ and Tau Oligomers in the Pathogenesis of Alzheimer’s disease.- 6. Oligomers of α-Synuclein in the Pathogenesis of Parkinson’s Disease.- 7. Cytotoxic Mechanisms of Islet Amyloid Polypeptide in the Pathogenesis of Type-2 Diabetes Mellitus (T2DM).- 8. Protein Misfolding and Toxicity in Amyotrophic Lateral Sclerosis.- 9. Structural Studies of Prion Proteins and Prions.- 10. Role of Prion Protein Oligomers in the Pathogenesis of Transmissible Spongiform Encephalopathies.- 11. When More Is Not Better: Expanded Polyglutamine Domains in Neurode-generative Disease.- 12. Protein Misfolding and Toxicity in Dialysis-Related Amyloidosis.- 13. Transthyretin Aggregation and Toxicity.- 14. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases.
Fields of interestsBiomedicine general; Protein Science; Protein Structure
T. Rőszer, Spanish National Cardiovascular Research Center, Madrid, Spain
The Biology of Subcellular Nitric OxideThis book fills in a gap in the NO literature.
Features 7 Fills a gap in NO biology-related litera-ture 7 Topics discussed have general biological relevance Interdisciplinary summary on recent advance on NO cellular biology 7 Chapter sum-maries and illustrations help rapid understand-ing of complex interactions 7 Can be used as a reference in scientific papers 7 Can be used as a lecture book
Contents Foreword.- Preface.- Part I General Concepts.- Introduction Part II Nitric Oxide Synthesis in Prokaryote Cells.- 2 Nitric Oxide is a Bioproduct In Prokaryotes.- Part III Nitric Oxide Synthesis in Plant Organelles.- 3 Nitric Oxide Synthesis in the Chloroplast.- 4 NO Synthesis in Leaf Peroxisomes And Plant-Type Mitochondria.- Part IV At the Edge of the Plant and Animal Kingdom.- 5 NO Synthesis iIn Subcellular Compartments of Fungi.- Part V Nitric Oxide Synthesis in Animal Cells.- 6 Harboring of NOS to the Cell Membrane.- 7 The Golgi System Contributes to NO Homeostasis.- 8 Phagosomal And Lysosomal NO Synthesis.- 9 NO Synthesis and Cell Locomotion.- 10 Nitric Oxide Synthesis in the Mitochondria of Animal Cells.- 11 Peroxisomes: Where NOS Rests In Peace?.- 12 Subcellular Redistribution of NOS.- Appendix.- Abbreviations.- Glossary.- Image Information.- Subject Index.
Fields of interestsBiomedicine general; Molecular Medicine; Cell Biology
Target groupsResearch
Product categoryContributed volume
Due February 2012
2012. I, 299 p. 63 illus., 14 in color. Hardcover7 € 139,95 | £126.007 * € (D) 149,75 | € (A) 153,94 | sFr 186,50ISBN 978-94-007-2818-9
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P. Salvi, University of Nancy, France
Pulse WavesHemodynamic approach to explain blood pressure values
Recently, several studies have shown the crucial role of viscoelastic properties of the aorta and large arteries in determining blood pressure values. A good knowledge of cardiovascular pathophysiology and vascular hemodynamics is necessary to understand these phenomena. How-ever, available texts on this topic are very complex and difficult for medical practitioners to under-stand. The aim of this book is to enable the reader to comprehend the relation between cardiovascu-lar pathophysiology and vascular hemodynam-ics and to become familiar with the more recent guidelines. While very complex physical concepts are involved, care has been taken to ensure that the explanations are as straightforward as possible. Complex analyses are presented separately and can be skipped by the reader without impairment of understanding. It is envisaged that the knowl-edge imparted will prove invaluable in improving the approach to hypertensive patients.
Features 7 Straightforward presentation of very complex physical concepts 7 Many figures and user-friendly language, ensuring that the text is readily intelligible 7 Separate presentation of complex analyses in boxes, allowing them to be skipped without impairment of understanding
Contents Introduction.- Mean arterial pressure.- Pulse Pressure.- Central blood pressure.- Appendix.- References.
F. H. Sarkar, Wayne State University, Detroit, MI, USA (Ed.)
Nutraceuticals and CancerFeatures 7 Neutraceuticals and Cancer Therapy 7 Tar-geted and Adjuvant Therapy 7 Approach reduc-ing systemic toxicity
Contents Preface.-1. Global Overview of the Role of Nutra-ceuticals in Cancer.-2. Cancer Stem Cells: Novel Target Using Dietary Components for Prevention and Treatment.-3. Polyphenols as Receptor Tyro-sine Kinase Inhibitors and Anti-Cancer Agents.-4. Role of Nutraceuticals on Nrf2 and Its Implication in Cancer Prevention.-5. Current Status and Fu-ture Prospects of Nutraceuticals in Prostate Can-cer.-6. Cellular, Molecular and Biological Insight Into Chemopreventive and Therapeutic Potential Of 3, 3’-Diindolylmethane (Dim).-7. Mechanism of Action of the Anti-Cancer Agent, Triptolide.-8. Nutraceuticals in Human Urinary Bladder Cancer Prevention andTreatment.-9. Exploiting resvera-trol for the treatment of cancer.-10. Role of novel nutraceuticals garcinol, plumbagin and mangiferin in the prevention and therapy of human malig-nancies: mechanisms of anticancer activity.-11. Anthocyanins and Cancer Prevention.-12. Slow but Steady Progress in Cancer Chemoprevention with Phenethyl isothiocyanate: Fulfilled Promises and Translational Challenges.-13. Skin cancer chemoprevention: Current status and future po-tential.-14. Dietary Phytochemicals and Chemo-prevention of Solar Ultraviolet Radiation-Induced Skin Cancer.-15. The Role of Vitamin E Forms in Cancer Prevention and Therapy – Studies in Human Intervention Trials and Animal Mod-els.-16. Augmenting the efficacy of chemo- and radio-therapy by nutraceuticals: Evidence from pre-clinical and clinical trials. Index.
Fields of interestsBiomedicine general; Cancer Research; Nutrition
B. Shapiro, The Pennsylvania State University, University Park, PA, USA; M. Hofreiter, University of York, UK (Eds)
Ancient DNAMethods and Protocols
Contents Setting Up An Ancient DNA Laboratory.-A Phenol-Chloroform Protocol for Extracting DNA from Ancient Samples.-DNA Extraction of An-cient Animal Hard Tissue Samples via Adsorption to Silica Particles.- Case Study: Recovery of ancient nuclear DNA from Toe Pads of the Extinct Passen-ger Pigeon.-Extraction of DNA from Paleofeces.-DNA Extraction from Keratin and Chitin.-Case Study: Ancient sloth DNA Recovered from Hairs Preserved in Paleofeces.-Ancient DNA Extraction from Soils and Sediments.-DNA Extraction from Fossil Eggshell.-Ancient DNA Extraction from Plants.-DNA Extraction from Formalin-fixed Material.-Case Study: Ancient DNA recovered from Pleistocene-age Remains of a Florida Armadillo.-Non-destructive DNA Extraction from Museum Specimens.-Case Study: Using a Non-destructive DNA Extraction Method to Generate mtDNA Sequences from Historical Chimpan-zee Specimens .-PCR Amplification, Cloning and Sequencing of Ancient DNA.-Quantitative Real-time PCR in aDNA Research.-Multiplex PCR Amplification of Ancient DNA.-Preparation of Next-generation Sequencing Libraries from Damaged DNA.-Generating Barcoded Libraries for Multiplex High-throughput Sequencing.-Case Study: Targeted high-throughput Sequencing of Mitochondrial Genomes from Extinct Cave Bears via Direct Multiplex PCR Sequencing (DMPS).-Target Enrichment via DNA Hybridiza-tion Capture.-Case Study: Enrichment of Ancient Mitochondrial DNA by Hybridization Capture.-Analysis of High-throughput Ancient DNA Sequencing Data. [...]
Contents The Neurotrophin Family of Neurotrophic Factors – An Overview.- Neuronal Growth-Promoting and Inhibiting Cues in Neuroprotection and Neu-rodegeneration.- Culture of Rat Cerebellar Gran-ule Neurons and Application to Identify Neuro-protective Agents.- Isolation and Culture of Neural Progenitor Cells from Rat Postnatal Cerebellum.- Culture of Rodent Cortical and Hippocampal Neurons.- Amyloid β-Peptide Neurotoxicity Assay Using Cultured Rat Cortical Neurons.- Culture of Neonatal Rodent Microglia, Astrocytes, and Oligodendrocytes from Cortex and Spinal Cord.- Central Nervous System Neuron-Glia Co-Culture Models.- Culture and Characterization of Rat Mesencephalic Dopaminergic Neurons.- Prepara-tion of Adult Spinal Cord Motor Neuron Cultures Under Serum-Free Conditions.- Rodent Retinal Ganglion Cell Cultures.- Culture of Purified Glial Cell Populations from Optic Nerve.- Isolation and Culture of Rat Cone Photoreceptor Cells.- Rat Retina Pigmented Epithelial Cells.- Mammalian Growth Cone Turning Assays Identify Distinct Cell Signalling Mechanisms that Underlie Axon Growth, Guidance and Regeneration.- Culture of Dissociated Sensory Neurons from Dorsal Root Ganglia of Postnatal and Adult Rats.- Culture and Proliferation of Highly Purified Adult Schwann Cells from Rat, Dog, and Man.- Use of PC12 Cells and Rat Superior Cervical Ganglion Sympathetic Neurons as Models for Neuroprotective Assays Relevant to Parkinson’s Disease.- Compartmented Chambers for Studying Neurotrophic Factor Action.- Preparation and Culture of Adrenal Chromaffin Cells.- Indirect Immunofluorescence Staining of Cultured Neural Cells. [...]
Fields of interestsNeurosciences; Neurobiology; Neurochemistry
R. Srivastava, S. Shankar, University of Kansas Medical Center, Kansas City, KS, USA (Eds)
Stem Cells and Human DiseasesContents 1. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications.- 2. The Perspectives of Stem Cell-based Therapy in Neurological Dis-eases.- 3. Stem Cell-based Therapy for Lysosomal Storage Diseases.- 4. Drosophila germline stem cells.- 5. Mesenchymal Stem Cells in Hematopoi-etic Stem Cell Transplantation.- 6. Cancer Stem Cells in Solid Tumors, Markers and Therapy.- 7. Cancer Stem Cells: Paradigm Shifting or Perishing Concept.- 8. Genomics of Prostate Cancer.- 9. Ischemia, reactive radicals, redox signaling and hematopoietic stem cells.- 10. Cancer stem cell models and role in drug discovery.- 11. Origins of Metastasis-Initiating Cells.- 12. The Reduction of Callus Formation during Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells.- 13. Stem cells and leukemia.- 14. The role of adult bone marrow derived mesenchymal stem cells, growth factors and scaffolds in the repair of cartilage and bone.- 15. Worth the Weight: Adi-pose Stem Cells in Human Disease.- 16. Neural crest and Hirschsprung’s disease.- 17. Common denominators of self-renewal and malignancy IN neural stem cells and GLIOMA.- 18. Stem-like cells from brain tumours or vice versa?.- 19. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics.- 20. Breast Cancer Stem Cells.- 21. Translin/TRAX deficiency affects mesenchymal differentiation programs and in-duces bone marrow failure.- 22. Cancer therapies and Stem cells.- 23. Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas.- 24. The Biology of Lung Cancer Stem Cells.- 25. Stem Cell Characters in Primary and Metastatic Tumour Establishment. [...]
Fields of interestsBiomedicine general; Literacy; Medicine/Public Health, general
H. M. Staines, S. Krishna, University of London, UK (Eds)
Treatment and Prevention of MalariaAntimalarial Drug Chemistry, Action and Use
Features 7 Gives a comprehensive account of the recent advances in anti-malaria drugs 7 Chapters contributed by expert authors 7 Describes new ideas and directions for study
Contents Antimalarial drugs and the control and elimi-nation of malaria.- 4-Aminoquinolines: chlo-roquine, amodiaquine and next generation analogues.- Cinchona alkaloids: quinine and quinidine.- 8-Aminoquinolines: primaquine and tafenoquine.- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyro-naridine.- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone.- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions.- Non-antifolate anti-biotics: clindamycin, doxycycline, azithromycin and fosmidomycin.- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate.- Second generation peroxides: the OZs and artemisone.- Combination therapy in light of emerging artemisinin resistance.- New medicines to combat malaria: an overview of the global pipeline of therapeutics.- Molecular markers of Plasmodium resistance to antimalarials.- Preven-tion of malaria.- Malaria diagnostics: lighting the path.
Fields of interestsPharmacology/Toxicology; Infectious Diseases; Parasitology
Target groupsResearch
Product categoryContributed volume
Due December 2011
2011. XX, 260 p. 57 illus., 15 in color. (Milestones in Drug Therapy) Hardcover7 € 139,95 | £126.007 * € (D) 149,75 | € (A) 153,94 | sFr 209,00ISBN 978-3-0346-0479-6
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L. W. Tari, Trius Therapeutics, San Diego, CA, USA (Ed.)
Structure-Based Drug DiscoveryThe last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.
Features 7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts
Contents The Utility of Structural Biology in Drug Discov-ery.- Genetic Construct Design and Recombinant Protein Expression for Structural Biology.- Puri-fication of Proteins for Crystallographic Applica-tions.- Protein Crystallization for Structure-Based Drug Design.- X-Ray Sources and High-Throughput Data Collection Methods.- The Use of Molecular Graphics in Structure-Based Drug De-sign.- Crystallographic Fragment Screening.- The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase.- Le-veraging Structural Information for the Discovery of New Drugs: Computational Methods.- Chemi-cal Informatics – Using Molecular Shape Descrip-tors in Structure-Based Drug Design.- Accounting for Solvent in Structure-Based Drug Design.- Structure-Based Drug Design on Membrane Pro-tein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein.- Application of SBDD to the Discovery of New Antibacterial Drugs.- Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering.- A Medici-nal Chemistry Perspective on Structure-Based Drug Design and Development.
Fields of interestsPharmacology/Toxicology; Medicinal Chemistry
A. Thiel, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany (Ed.)
ImmunosenescenceAs individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoim-munity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-as-sociated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective preven-tion and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population.
Features 7 Describes molecular aspects of the aging immune system 7 Discusses new therapeutic approaches 7 Written by internationally reputed scientists
Contents Regulation of Adaptive Immunity in the Elderly.- Does Innate Immunity Get Old?.- Thy(-Im)Munosenescence: The Ageing of the Thymus and Its Impact on the Immune System.- Character-istics of B Cells and B Cell Responses in Aged Individuals.- Mechanisms of Immune Protection to Pneumococcal Infection in the Young and the Elderly.- CMV Subversion of the Immune System in Later Life.- Aging and Autoimmunity.- Vaccina-tion in the Elderly.- Immunosenescence and the 3r’s; Restoration, Replacement and Reprogram-ming.- Novel Strategies of Improved Vaccines for Elderly: The Example of Influenza.
Fields of interestsBiomedicine general; Immunology; Molecular Medicine
H. G. Vogel, J. Maas, Aventis Pharma, Frankfurt, Germany; F. J. Hock, Dieburg, Germany; D. Mayer, Idstein, Germany (Eds)
Drug Discovery and Evaluation: Safety and Pharmacokinetic AssaysSafety aspects have become an outstanding issue in the process of drug discovery and development.
Features 7 Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
Fields of interestPharmacology/Toxicology
Target groupsResearch
Product categoryHandbook
Due June 2012
Print
2nd Edition. 2012. 1000 p. (In 2 volumes, not available separately) 7 approx. € 499,00 | £449.507 approx. * € (D) 533,93 | € (A) 548,90 | sFr 664,50ISBN 978-3-642-25239-6
