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Dementia Care and Research in ChinaDementia Care and Research in China
Huali WangPeking University Institute of Mental Health
Beijing Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia
National Clinical Research Center for Mental Disorders
2Peng X. Science 2011;333:581-587.
Total population: 1.0 billion Total population: 1.3397 billion
Demographic ChangesDemographic Changes
3
Meta-analysis: 9.19 million persons with dementia in 2010
Chan YT, et al. Lancet 2013; 381:2016-23
4Jia J, et al. Alzheimer’s & Dementia 2014;10(1): 1–9.
5
Informal caregiving time and cost
Wang H, et al. Ageing Int 2010;35:153-165
6
Response to the dementia challengeResponse to the dementia challenge
19992001
National Mental Health Plan
2001-2005
2002-2010
2011-2020
2016-2020
China Aging Development Plan (1994-2000)The 10th 5-Year Plan for China Aging Development (2001-2005)The 11th 5-Year Plan for China Aging Development (2006-2010)
White Paper on China Aging Development (2006, the State Council)
The 12th 5-Year Plan for China Aging Development (2011-2015)
2006 2011 2016
National Science & Technology Development
harmonization of assessment instruments (2001-2005) Epidemiology (2006-2010)
New Drug Discovery (2006-2020)Basic science research (2011-2015)
Precision medicineNational Brain Initiative
NCDs management
Improving timely diagnosis and care
8
Delay in seeking diagnosis
Zhao M, et al. Int Psychogeriat 2016;28(2):211–219
9
Improving access to diagnosis
Clinical diagnosis(dementia, MCI)
Cognitive screening
Public health educationTraining community workers
10Xie H, et al. Chinese Journal of Internal Medicine 2014; 53(12):1002-1006
Alzheimer’s Disease Chinese
Consensus on routine memory
check-up for people at
risk of dementia
11
Effect of training for community doctors
3.44%
0.65%0.0%0.5%1.0%1.5%2.0%2.5%3.0%3.5%
screening rateIntensive training Routine training
p=0.036
Hu L, et al. Chinese General Practice 2015
12
Biomarkers for AD diagnosis
Wang et al. Hum Brain Mapp 2015;36:1828-1846 Meng et al. Scientific Reports 2015
13
Caregiver intervention
-0.6
-0.3
0
0.3
0.6
0.9
1.2
NPS
impr
ovem
ent
mea
sure
d w
ith N
PI-Q
4w vs. baseline 12w vs. baseline
Intervention group control group
Zhou S, et al. Peking University Master thesis (2014)
Future research priorities
Aiming to improve accessibility and
affordability of diagnosis, care and
prevention
15
Biomarkers for early diagnosis Culturally appropriate screening and
diagnosis technology Novel drug discovery Caregiver support and intervention Lifestyle support for cognitive health
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