Date post: | 30-Dec-2015 |
Category: |
Documents |
Upload: | anthony-leo-hamilton |
View: | 215 times |
Download: | 2 times |
Hybrid Fluorescence Molecular Tomography– X-ray Computed Tomography method and system
Administrative + Financial Aspects • Project Overview
• Reporting
• Deliverables & Milestones
Veronika Erben
HHybridybrid FFluorescenceluorescence MMolecularolecular TTomographyomography –– XX--rayray CComputedomputed TTomographyomography method and systemmethod and system
Acronym: FMT-XCT
Collaborative project: Small or medium-scale focused research project
Grant agreement No: 201792
Starting date: 1st March 08
Duration: 4 years
Funding: European Commission- FP7
Funding rate: € 4.5 Mio
Partners/Beneficiaries FMT-XCT
University College London
Commissariat a L’Energie Atomique
Fudacion para la Investigacion Biomedica del Hospital Gregorio Marañon
Verfahren und Apparate derMedizinischen Physik
Technische Universität München
Executive CommitteeExecutive CommitteeHMGU/TUM: Prof. Vasilis Ntziachristos (WP1,5,9)
CEA-Leti: Prof. Philippe Rizo (WP2)
Forth: Dr. Jorge Ripoll( WP3)
UCL: Prof. Simon Arridge (WP4)
CEA-Lime: Prof. Bertrand Tavitian (WP6)
UZH: Prof. Markus Rudin (WP7)
FIHGM: Dr. Juan Jose Vaquero (WP8)
Vamp: Dr. Holger Brünner
Executive CommitteeExecutive CommitteeHMGU/TUM: Prof. Vasilis Ntziachristos (WP1,5,9)
CEA-Leti: Prof. Philippe Rizo (WP2)
Forth: Dr. Jorge Ripoll( WP3)
UCL: Prof. Simon Arridge (WP4)
CEA-Lime: Prof. Bertrand Tavitian (WP6)
UZH: Prof. Markus Rudin (WP7)
FIHGM: Dr. Juan Jose Vaquero (WP8)
Vamp: Dr. Holger Brünner
ReasearchersReasearchersDr. Ralf Schulz, Dr. Marta Zientowska, Anelique Ale, Dr. Giannis Zacharakis, Dr. Veronique Rebuffel, Dr. Alejandro Sisniega, Dr. Manuel Desco, Marco Brambilla, Dr. T. Rudge, Dr. V.Soloviev, Dr. J.Elisee, Dr. Juan Aguirre, Dr. Judith Chamorro, Dr. Katerina Dikaiou, Dr. Sandra Bürki, Dr. Florian Stuker, Dr. Garafolakis Anikotos and others
ReasearchersReasearchersDr. Ralf Schulz, Dr. Marta Zientowska, Anelique Ale, Dr. Giannis Zacharakis, Dr. Veronique Rebuffel, Dr. Alejandro Sisniega, Dr. Manuel Desco, Marco Brambilla, Dr. T. Rudge, Dr. V.Soloviev, Dr. J.Elisee, Dr. Juan Aguirre, Dr. Judith Chamorro, Dr. Katerina Dikaiou, Dr. Sandra Bürki, Dr. Florian Stuker, Dr. Garafolakis Anikotos and others
Advisory CommitteeAdvisory Committee
Prof. Markus Schwaiger – TUM
Prof. Clemens Lowik – Leiden University
Prof. Chrit Moonen – University Victor Segalen Bordeaux
Advisory CommitteeAdvisory Committee
Prof. Markus Schwaiger – TUM
Prof. Clemens Lowik – Leiden University
Prof. Chrit Moonen – University Victor Segalen Bordeaux
Coordinator: HMGUCoordinator: HMGU Project leader: Prof. Vasilis Ntziachristos Project manager: Dr. Veronika Erben
Coordinator: HMGUCoordinator: HMGU Project leader: Prof. Vasilis Ntziachristos Project manager: Dr. Veronika Erben
= Consortium
European CommissionProject officer: Dr. Torbjoern Ingemannson
Management structure
Management Support Management Support TeamsTeams
Project management office
Financial departments
Legal departments
Communication /press
Management Support Management Support TeamsTeams
Project management office
Financial departments
Legal departments
Communication /press
Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting PeriodsWork packagesWork packages
TECHNICAL DEVELOPMENT IN-VIVO ALGORITHMIC TRAINING & PRE-CLINICAL IMAGING
Cancer imaging with focus on breast cancer imaging (Wp6)WP leader CEA-Lime
Imaging Cancer Therapy for enabling
intervention (Wp7)WP leader: UZH
MANAGEMENT (Wp1) WP leader: HMGU
Theory for 360 degree FMT (Wp3)WP leader: FORTH
FMT Inversion with priors (Wp4)
WP leader: UCL
FMT-XCT integration (Wp5)
WP leader: HMGU
TRAINING, DISSEMINATION &TECHNOLOGY TRANSFER (Wp9) WP leader: HMGU
XCT Development (Wp2)WP leader: CEA-Leti
FMT-XCT Imaging accurancy vs PET-XCT (Wp8)WP leader: FIHGM
Report
Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting Periods
12 months
Officia
l sta
rting
date:
Mar
ch 01
,2008
t
Febru
ary 2012
Febru
ary 2011
Reporting ScheduleReporting Schedule
Febru
ary 2009
Febru
ary 2010
• Periodic report (WP and Management report) + financial report
• 60 days after the end of each reporting period • No incomplete reports
12 months 12 months 12 months
+60
days
Report Report Report
ReportingPeriod
1
ReportingPeriod
2
ReportingPeriod
3
ReportingPeriod
4
Activity report:
1. Publishable summary
2. Project objectives for the reporting period
3. Work progress and achievements during the period:
For each work package -- except project management
4. Deliverables and Milestones tables
5. Project Management
6. Explanation of the use of the resources
Periodic reportPeriodic reportbased on Annex Ibased on Annex I
3. Work progress and achievements during the period/WP
• Summary and Progress towards objectives• Technical appendix (can also include deliverables)
4. Deliverables and Milestones tables• Deliverables that are of a nature other than written "reports", such as
"prototypes", "demonstrators" or "others", should also be accompanied by a short report, so that the European Commission has a record of their existence
6. Explanation of the use of the resources/Partner• More detailled as Form Cs
Reporting ScheduleReporting Schedule4 Year Collaborative Project with 4 Reporting Periods4 Year Collaborative Project with 4 Reporting Periods
Periodic reportPeriodic report based on Annex Ibased on Annex I
Financial reporting
Financial ReportFinancial ReportForm CsForm Cs
Form Cs: Excel table
FORCE WEB BASED EDITOR
OF FORMS C FOR FP-6 AND FP-7
FORCE WEB BASED EDITOR
OF FORMS C FOR FP-6 AND FP-7
Online reporting tool
FORCE WEB BASED
EDITOROF FORMS C FOR
FP-6 AND FP-7
FORCE WEB BASED
EDITOROF FORMS C FOR
FP-6 AND FP-7
Online reporting tool
• Coordinators can registering via SESAM
• Only the coordinator should have access and submit Forms C to the Commission
• Next version: individual access/Partner
Financial report Financial report FORCEFORCE
FORCEFORCEFORM C EDITOR FORM C EDITOR
register as a new user in SESAM/FORCE
FORCEFORCEFORM C EDITOR FORM C EDITOR
register as a new user in SESAM/FORCE
Financial reportFinancial reportFORCEFORCE
Description available how to register and use FORCE http://webgate.ec.europa.eu/sesam/index.do;jsessionid=V2XyJk0Ybcn8vLG803x1YPQJq1dPQSnhJLky6vWZ1dT3DG24MCLL!-1976463397!-1882849135
Total EC contributionTotal EC contributiondue to Annex1 [€]due to Annex1 [€]
August 08August 08[€][€]
April/MayApril/May[€][€]
July/AugustJuly/August[€][€]
1 HMGU 1.294.102 323.525 129.410 ?
2 CEA 1.212.389 303.097 121.239 91.026
3 FORTH 488.550 122.137 48.855 42.742
4 UCL 409.600 102.400 40.960 43.165
5 FIBHGM 478.400 119.600 47.840 138.900
6 UZH 365.600 91.400 36.560 36.260
7 VAMP 263.500 65.875 26.350 24.049
TOTAL 4.512.141 1.128.034 451.214
1st
prefinancing
2nd
prefinancing
spent in
year 1 (F
orm C)
Payment SchedulePayment Schedule
• Transfer between activities (RTD, Management, Other) possible; should be clarified EC
•A certificate on the financial statements (certificate of the accounting system) is only required when the amount of financial contribution is equal to or superior to EUR 375 000
• Money can be transfered to next year
Payment SchedulePayment Schedule
audit
• + 5 years after end of the project• time sheets
AuditAudit
• Next consortium meeting mo 24 = Feb.2010 (Where? When?)
WP1 ManagementWP1 Management
Deliverable No
Name Month
1.1 Consortium Agreement March `08
1.2 Minutes of the kick off meeting March `08
1.3 Project website and updates Feb. `09, Feb. `10, Feb. `11
1.4 Program of the consortium meetings Feb. `09, Feb. `10, Feb. `11
1.5 Half time report Feb. `10
WP2 XCT DevelopmentWP2 XCT Development
--LETILETI
• Milestone No 5 (mo 18= August 09): XCT dual energy vs. contrast enhancement
Deliverable No Name Month
2.1 XCT design March ` 08 Nov ` 08
2.2 Dual energy protototype May `09 Dec`09
2.3 Dual energy processing software May `09 Aug. `09
2.4 Preliminary technical specifications Aug.`09
2.5 Scattered energy measurements Nov. `09
2.6 Comparison of contrast enhancing strategies Feb. `10
2.7 Final technical specification for XCT system Feb. `10
WP3: Theory for 360 degree FMTWP3: Theory for 360 degree FMT
• Milestone No. 4 (month 15 = May 09): Direct vs Conventional FMT performance
* New Deliverable „Ultra- fast Inversion for FMT“ month 24=Feb. 10
Deliverable No Name Month
3.1 Direct inversion algorithm for fluorescence implementing boundary removal principles
Nov`09
3.2 Experimental training set measurements to serve as a training set for algorithmic optimization
Feb. `09
3.3 Quantitative evaluation of direct inversion performance vs established FMT inversion methods
Aug. `09
3.4 Multi-spectral algorithm Nov. `09
3.5 User friendly software environment Feb.`10
WP4: FMT inversion with image priorsWP4: FMT inversion with image priors
• Milestone No 6 (month 21 = Nov 09): Optimal FMT inversion with priors
Deliverable No Name Month
4.1 Inversion algorithms for improving recontruction Nov. `09, May `10
4.2 Quantification of algorithmic performance with simulated data Nov.`09
4.3 Inversion algorithms to determine the optical attenuation of different organs/tissues
Feb.`10
4.4 An automatic feature extraction algorithm Feb.`10
WP5: FMT –XCT integrationWP5: FMT –XCT integration
• Milestone No 8 (mo 24 = Feb. `10) : FMT-XCT Shielding
Deliverable No Name Month
5.1 360 degree FMT prototype Feb. `09
5.2 Optimal settings May `09
5.3 Gantry delopment Feb. `10
WP6: Cancer imaging with focus on breast cancerWP6: Cancer imaging with focus on breast cancer
Deliverable No Name Month
6.1 LIME To develop and characterize molecular probes Nov.`09, Aug. `10
6.2 LIME/HMGU?
Prepare mammary tumor animal models (lung and brain cancer)
Aug. `10
6.3 LIME Breed and make available PyMT animal models Feb. `10
Lime
WP7: Imaging cancer therapy for enabling interventionWP7: Imaging cancer therapy for enabling intervention
Deliverable No Name Month
7.1 Preparation of HIF transfected cancer cells Nov. 08
7.2
FMT of HIF induction of breast tumors May 09
WP8: FMT-XCT imaging accuracy vs. WP8: FMT-XCT imaging accuracy vs. PET-XCTPET-XCT
Deliverable No Name Month
8.1 Construct imaging phantoms Feb. `09
8.2 Phantom characterization with PET, FMT and XCT and appropriate probes
Feb.`10
, WP9: Training & DisseminationWP9: Training & Dissemination
Deliverable No Name Month
9.2 Training curriculum and implementation document
Feb.`09
• CEA-LETI will house a training session on XCT on mo.12 Veronique Rebuffel: May/June 09
• Crete will house a training session jointly with UCL on free-space FMT on mo. 24 (=Feb. 10)