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CURRICULUM VITAE -

THOMAS F. BUDINGER, H.D., Ph.0.

T i t l e s : Henry H i l l e r Professor o f Medical Research

Donner Laboratory a t Lawrence Berkeley Laboratory

F a c u l t y Senior Sc fen t ls t , Lawrence Berkeley Laboratory

Professor of B io inst rumentat ion, E l e c t r i c a l Engineer ing and Computer Sclences

U n i v e r s i t y of Cal i f o r n i a , Berkeley

Professor of Radiology, Un i vers i ty of C a l i f o r n i a,

San Francisco

Board C e r t i f i e d i n Nuclear Medicine, 1973

Room 230 Danner Laboratory U n i v e r s i t y of Cal f f o r n i a

Lawrence Berkeley La bo r a t o r y Berkeley , Cal i f o r n i a 94720

M a i l i n g Address:

Telephone: (41 5 ) 486-5435

Education:

, Ph.0. U n i v e r s i t y of C a l i f o r n i a , Berkeley - Medical Physlcs 1 9 7 1 H.D. U n i v e r s i t y of Colorado, Denver 1964 M.S. U n i v e r s i t y of Washington, S e a t t l e - Physica l Oceanography 1957 B.S. Regis College, Denver - Chemistry ( A n a l y t i c a l ) 1954

Honors and Awards: --- Magna Cum Laude, Regis Col lege Top Man Award (USCG Academy, DCS) Gold-Headed Cane (Top Man i n Medicine), U n i v e r s l t y of Colorado

Cec i l H. and Ida H. Green V i s i t i n g Scholar, b r i n e Biomedical I n s t i t u t e , U n i v e r s i t y of Texas Medlcal Branch a t Galveston

Amertcan Nuclear Society Team Award f o r Speclal Achlevement

Loulse and L ione l Berman Foundation Award f o r k l c n t l f l c

1954 1957 1964 1974

1981

1984

1985

V i s i t i ng Professor, Un lvers i ty o f C inc innat i , Ohlo

I n Nuclear Technology f o r Hedlcal Dlagnost lcs

Cont r ibu t ions i n t h e Peaceful Uses o f Atonic Energy

Professional Appointments:

Chalnnan, D iagnost ic Radiology Study Section, N I H 1982 - 1985 Professor, Department o f Radlology, U n i v e r s i t y of C a l i f o r n i a

San Francisco Medical Center 1984 - pres Henry H i l l e r Professor o f Medical Research 1976 - pres Professor, Department o f E l e c t r i c a l Engineer ing and Computer Sciences, U n i v e r s i t y o f C a l i f o r n i a , Berkeley 1976 - pres

Head, Research Medicine Group, Odnner Laboratory 1976 - pres D i rec tor , Donner Medical Group 1977 - pres

1968 - pres

1980 - pres 1978 - pres

Medical D i rec to r , Medical Services, L.B.L. 1968 - 1976 Research Physician, Donner Laboratory P r inc ipa l I nves t i ga to r , Program P r o j e c t Grants

Cardiovascular F l o w and Hetabol ism (NIH) Q u a n t l t a t l v e Card iovascular Research (NIH)

V i s i t i n g Professor, Un ive rs i t y of C lnc inna t i Feb. 1974 Phys ic is t , Lawrence L i vermore Laboratory 1966 - 1968

Medical In te rn , Peter Bent Brfgham Hosp i ta l , Boston 1964 - 1965 Senior Oceanographer, U n i v e r s i t y of Washington 1960 - 1964 Science O f f i c e r (USCG) I n t e r n a t i o n a l I c e Pa t ro l 1958 - 1960 Oceanographic and Meteorology O f f i ce r (USCG) 1957

Ana ly t i ca l Chemist, I n d u s t r i a l Laborator ies, Denver 1954

Professional Soc ie t ies :

Society of Nuclear Medlcine American Geophysical Union Cardiac Radiology American Meteorol og i ca l Socl e t y B r i t i sh In te rp lane ta ry Society

sigma X I Alpha Omega Alpha

Nor th American Socfety f o r

New York Academy o f Science A.A.A.S.

The Society of Magnetic Resonance i n Medicine

Comnittee Memberships:

Diagnost ic Radiology Study Section, N.I.H., D i v i s i o n of Research Grants,

-University of C a l i f o r n i a Bioengineer ing Execut ive Committee Lawrence Berkeley Laboratory and Donner Laboratory Human Use Comnittee L.B.L. Biology and Mediclne D iv i s ion , Program Advisory Comnittee Los Alamos S c i e n t i f i c labora tory , Advlsory Comnittee on Medical

Radioisotopes, Chairman Medical I n te rna l Rad ia t lon Dose Comnittee, Soc. o f Nuclear Medicine Comnittee on B i o l o g i c a l E f fec ts , Corn. on Nuclear Magnetic Resonance,

American Col lege of Radiology, Chairman Technical E lec t ron i c Product Rad ia t ion Safety Standards Comnittee

Food and Drug Admin is t ra t ion , January 1, 1982 through Dec. 31, 1985 Lawrence Berkeley Laboratory S t a f f Committee

Chairman, J u l y 1, 1982 through June 30, 1985.

T. F. Budlnger C u r r l c u l m V l t a e Page 3

Chronological Sumnary o f Pub1 i c a t i o n s , Reports and Presentat ions

Gould, HR cnd Tf Budlnger. Control of r e d h e n t a t i o n and bottom c o n f i g u r a t i o n by convcct lon cu r ren t , Lake Uashlngton, Uashlngton. J . b r i n e Res. 17:

- --

183-198, 1958.

Budlnger I F . 49-97, a l s o as c o n t r l b u t l o n no. 1093, C o l l e c ~ ~ t ~ t V o o d s c Occanographlc I n s t f t u t l o n , 1959.

Iceberg d e t e c t i o n by radar. U.S. b a s t Guard B u l l . No. 45, pp

Budlnger TF and W Enbysk. Cobb Seamount, a deep-sea fea tu re o f f t he Washington coast, Unlv. Uashlngton, Tech. Rcpt. no. 60, 83 pp, 1960.

Budfnger TF. Washington, Dept. of Oceanography Ref. m61-36, 16 pp, 1961.

Anderson C, CA Barnes, TF Budinger, CM Love and 0 McManus. discharge area of the nor theast P a c l f l c Ocean: A l l t e r a t u r c survey. Univ o f Yashlngton, Dept. of Oceanography Special Report Ref. Wl-25, 99 pp, 1961.

Budinger Tf, LK Coachman and CA Barnes. Northeast P a c i f l c Ocean, 1961, 1962: Selected aspects of phys l ca l oceanography, Univ. o f Ua$hlngton, Dept. o f Oceanography Tech Rcpt. no. 98, 78 pp, 1964.

Budinger TF and RJ Howerton. Time v a r f a t i o n of rep roduc t l ve processes i n b i o l o g i c a l c e l l s , Unlv. o f Ca l l f o rn la , Laurence Rad ia t l on Laboratory Rept.

Budinger TF and RJ Howerton. Charac te r i za t i on of t h e v a r l a t i o n s o f rep roduc t i ve processes I n l i v i n g c e l l s , Nature 214, 397-399, 1967.

Budinger TF. I n d i r e c t s t l m u l r t i o n o f t he v i s u a l apparatus, Lawrence Rad ia t i on Laboratory Rept. UCRL-18347, 1968.

Glaeser RM, and TF Budinger. Computer-sfmrlated Four ie r images i n r e l a t i o n t o b i o l o g i c a l e l e c t r o n microscopy, J- U l t r a s t r u c t u r e Res. 30, 238,

Parachute drogue obsc rva t l on t n the Columbla plume, Univ. o f

The Columbia R ive r

Columbia R Ivc r a f f l u e n t i n t h e

UCRL-1437, 2 2 ~ ~ . 1966.

1970

Budinger TF. Fron ta l a t tack on r a d i a t i o n , k l e n c c 168:315, 1970.

Yano D VanDyke, TF 8udlngcr. HO Anger and P Chu. Myocardial uptake s tud ies w i t h '"Cs and the s c l n t l l l a t i o n camera, 3. Nucl. Ned. 11, 663-668, 1970.

t l a e s e r RM, TF Budinger, PH Aebersold and G Thomas. b i o l o g i c a l specimens, Proc. In tern. Congress E lec t ron Microscopy, Grenoble, 1970.

---- Radia t i on damage i n

Budinger TF, VP E l i s c h e r and HI Hogan. processing of s c l n t i l l a t l o n camera output by d i g i t a l systems, LBL Rept. no.

Budinger TF, CA Tobias, JT Lyman, PK Chapman, LS Pinsky, H Blschel , JD Denny and UB Nelp. S c BIolo

High speed data a c p u i s l t i o n end

LBL-532, 1971. 0 0 c

L i g h t f l ash phenomenon seen by astronauts, Proc. Co l l o ulum of Related t o Post-Apollo Program of ESRO, E S R O X I k E

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Glaeser RM, I Kuo and TF Budinger. reduced l e v e l s o f e l e c t r o n I r r a d i a t i o n , -- SOC. h e r . , C. 3. Arceneau, ed., Boston, E.Tc Budinger TF, RJ Howerton and EF Plechaty. humans: Theore t ica l studies, Phys. Wd. B io l . 16, 439-450, , 1971.

Toblas CA, TF Budinger and JT Lyman. Observations by human sub jec ts on rad ia t ion- induced l i g h t f lashes i n f a s t neutron, X-ray, and p o s i t i v e i o n beams, -- Nature 230, 596, 1971; LBL-19868,

Budinger TF. App l i ca t i ons I n e l e c t r o n microscopy and nuc lear medicine, Rept. No. LBL-565, 1971.

Tobias CA, TF Budinger and JT Le i th , A-H Mamoon. cosmic rays and accelerated p a r t i c l e s , Proc. Advisory Group f o r Aerospace Research and Development, NATO, 1971.

Budinger TF, H Bichsel and CA Tobias. Visual phenomena noted by human sub jec ts on exposure t o neutrons o f energies l e s s than 25 MeV, Science 172, 868-870, 1971.

Method f o r process ing o f p e r i o d l c images a t 29th Ann. Proc. E lec t ron Microscopy

Neutron radiography and dosimetry i n

1971.

Transfer f u n c t i o n theory and image eva lua t i on i n b io logy : Ph.D. thesfs, L.B.L.

Visual phenomena induced by

Chapman P, LJ Pinsky, R Benson and TF Budinger. f lashes observed on Apo l lo 14, Proc. Nat. S Natural and Manmade Rad la t ion - i n Space, NASA Rept. N A S A - T H - X - 2 m p m 2 % k

- - Cosmic ray induced l i g h t

Budinger TF, JR F a m e l l , AR Smith and H Bichsel . de tec t i on by neutron a c t i v a t i o n w i thout chemical separation, I n t . J. Appl. Radiat. Isotop. 23, 49, 1972.

Human t i s s u e t r a c e element

Tobias CA, TF Budinger and JT Lyman. exposure, Proc. Nat S Natural and Manmade Rad ia t ion i n Space, NASA Rept. NASA-T!l-X-2-p%6* 1972. - -

Human v i sua l response t o nuclear p a r t i c l e

Budinger TF. s c i n t i l l a t i o n camera images, J. Nucl. Med. 13, 418, 1972.

Budfnger TF and Y Yano. Nucl. Med. 13, 417, 1972.

L i m i t a t i o n s i n data man ipu la t ion and presenta t ion of

Myocardial f u n c t i o n eva lua t i on by uptake o f 12%s, J. --- Budinger TF and RH Glaeser. objects, Proc. 5th Euro ean Con ress of Elec t ron Microscopy, The I n s t i t u t e of Physics, w n , pp&,+

Budinger TF. Rapid manipulat ion and d i sp lay o f counts vs t lme curves by

2nd d F 7 2 & 3 * . hardware and software, i n Nuclear Medicine, A . E T ep t

Budinger TF, JT Lyman and CA Tobias. nuc le i i n t e r a c t i n g w i t h the human r e t i n a , Nature 239, 209, 1972.

Phase changes on e l e c t r o n s c a t t e r i n g from t h i n

Sharin o f Com u t e r Pro rams and Technology --

Visual Percept ion o f accelerated n i t rogen

I- ... 1

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Budinger TF. Aspects of d i g i t a l ana lys l s o f card iac rad ionuc l l de f low studies, In, 3rd S Sharin o f Computer Programs and Technology i n Nuclear Medicine, Oak mg$?e&7X

Toblas CA, TF Budinger and JT Lyman. accelerated heavy p a r t i c l e s and t h e DrOblemS o f nervous system exoosure i n

B i o l o g i c a l e f fec ts due t o s i n g l e

space, Akadami e - V e r K -pfl3&,13m- - in, L i fe -S i l ences and 5 ace Research X I , PHA Smith, ed., '

Budinger TF. C l l n i c a l and research q u a n t i t a t l v e nuc lear medicine, i n , Medical Radioisoto e Scint igraphy, 1972, v01. 1, IAEA, Vienna, 1973, pp 5m55,+

Budinger TF. camera, LBL repo r t LBL-2145, 1973; abst ract , J. Nucl. Med. 14, 383-384, 1973.

Derenzo SE. TF Budinger, RG Smits. H Zakland and LW Alvarez. L iau id xenon

High count ing r a t e performance of t h e Anger s c i n t i l l a t i o n

f i l l e d w i r e chambers-for medical imaging appl icat ions, Proc. !$?TI+ Advanced Research, Argon-tiona Labaratory,

Gul lberg GT, and TF Budinger. imaging, J. Nucl. Med. 15, 497-498, (Abstract) , 1974.

Moyer BR and TF Budlnger. Francisco Bay,

LBL-2642, UC-11 Energy and Environmental and Ear th Sciences, TID-4500-R61, 37 pp, 1974.

Budinger TF. Icebergs and pack ice, in , Encyclopedia B r i t ann ica Vol. 9,

Budinger, TF, GT Gullberg, J *Rae and HO Anger. I so tope d i s t r i b u t i o n recons t ruc t i on from m l t i p l e g a m camera views, J. Nucl. Med 15, 480, (Abstract ) , 1974.

Zakland H . SE Derenzo. TF Budinger. and LW Alvaret .

At tenuat ion c o r r e c t i o n f o r three-dimensional

Cadmium l e v e l s I n t h e sho re l i ne sediments o f San In, Proc. VIII Trance Substances I n Environmental Health Conf.,

OD Hempht 11, ed., U n z f m s x C o l umbl a, MO';-; 1974 , pp 1 2 7 - 1 m ~ C

154-161, 1974.

L i a u i d xenon m r l t i w i r e p ropor t t ona l chambers- for n u c l e i r &dtc i ne appl l c a t i o n s ,' Ft r s t World Congress -- of Nuclear Medicine, Tokyo, pp 362-367, 1974.

Budinger TF, J *Rae, Y Yano, and WG Myers. Myocardial imaging w i th 81Rb, J . Nucl. Med. 15, 480, (Abs t rac t ) , 1974.

- --- Hathieu L, TF Budinger. P inhole d i g i t a l tomography, F i r s t World Congress of Nuclear Medicine, Tokyo, pp 362-367, 1974.

Budinger TF, K Crowe and LL Kanstein. radiography a t t h e 184-inch cyc lo t ron , LBL repo r t LBL-2654, 1974.

Budinger TF. Ouan t i t a t i ve nuclear medicine imaging: Appl icat ions o f computers t o the g a m camera and whole body Scanner, Nuclear Medicine, JH Lawrence, Ed.. Chapter 2, Grune and St ra t ton , NY, PP

Prel iminary experiments w i t h he l i um i o n

In, Recent Advances E 41-130,r

Culon Na 3 aF& I Fddu No.

T. F. Budinger Curr iculum V i tae Page 6

Budlnger TF. Recent advances I n 3-0 Imaging i n nuc lear medicine. Trans. Amer. Nucl. Soc. 19, pp 41-42,

Budlnaer TF. Y Yano. and J McRae. Rubidium-81 used as a myocardium lmaalna

1974. ---- agent; Schattauer Verlag, S t m g a r t , pp 2-15, 1974.

k s e l l s c h a f t f u r Nuk learked i t in , B )4111amos, MI Pabjt , G Hor, ed;. FK

Fisher 04, TF Budinger, A Fo in and TE Everhart. Harmosa m i t i s , Mutat ion Res. 22, 299-304,

Budinger TF and GT Gullberg. Three dimensional recons t ruc t i on I n nuclear medicine by i t e r a t i v e l e a s t squares and Four ie r t rans form technlques, LBL repo r t LBL-2146, 1973; also, IEEE Trans. Nucl. Scl NS-21(3), 2-20, 1974.

Budinger TF, and GT Gullberg. Three dimensional recons t ruc t i on o f isotope d i s t r i b u t i o n s , Phys. Hed. B fo l . 19, 387-389, 1974.

Budinger TF, and GT Gullberg. Three-dlmenslonal Imaging from m u l t l p l e gama camera views, F i r s t World Congress o f Nuclear Medfcine, Tokyo, pp 1267-1272, 1974.

Rudinger TF, Crowe K, Cahoon JL, E l l s h e r VP, Gu l lberg GT, Huesman RH, and Kanstein LL: Two- and three-dimensional d i g l t a l Image processlng f o r medical d iagnosis us ing photons and alpha p a r t i c l e s . Presented a t t h e 8 th Asllomar Conference OR C i r c u i t s , Systems, and Computers, December 1974.

Sudinger TF, Y Yano, and B Hoop Jr. myocardial p o s i t r o n sc in t ig raphy . J. Nucl. Med. 16, 429-431, 1979.

Moyer BR, and TF Budinger. soi ls and sediments f o r cadmium, Energy and Environment Annual Report, LBL 1975.

Derenzo SE, Y Zaklad and TF Budlnger. A n a l y t i c a l study o f a h igh r e s o l u t i o n pos i t ron . r i n g de tec tor system f o r t r a n s a x i a l recons t ruc t i on tomography, 3-

Crone KM, Budinger TF, Cahoon JL, E l l s c h e r VP, Huesman RH, and Kanstein LL: Ax ia l scanning w i t h 900 He!! alpha p a r t i c l e s . Lawrence Berkeley Report LRL-3B12, IEEE Trans Nucl Sci NS-22: No 3, 1752-1754, 1975.

Spontaneous chromosome gaps I n 1974. --

A comparison o f *%b and 13NH fo r

An improved technlque f o r the q u a n t i t a t i v e assay o f

NuCl . Med. 16, 1166-1173, 1975. ---

----- Budinger TF. Computer ass is ted Imaglng procedures and techniques i n nuclear medicine, i n , Nuclear Medicine i n C l i n i c a l Ped la t r i cs , H. Handmaker and JH Lowenstei n, eds., Soci e t y c x a r n e , NY, pp 243-260, 1975.

Budinger TF, and J Harpoot l ian. Developments..in d i g l t a l computer implementation i n nuclear medicine lmagfng. Computers Biomedical Research - 8, 26, 1975.

Budinger TF, FH DeLand, HE Duggan, JJ Bout, UT FkLaughlin, and PH Weber. Dynamic time-dependent ana lys is and s t a t i c three-dimenslonal imaging procedures fo r computer ass is ted CNS studies, Ima I n Usin &o& o f Nuclear Medicine, pp 45-66, 1975.

i n , Past p resent and Future of Brain Noninvasive Techniques, H I kBtanc and J A X r e n s o n , eds., Mew

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Budinger TF. tomography, J. Nucl. h d . 16, 517-518, (Abs t rac t ) , 1975.

Budinger TF, KH Crowe, JL Cahoon, VP E l i sche r , RH Huesman, LL Kanstein. Heavy p a r t i c l e radiography, Presented a t 1975 Winter Meetlng, Amerlcan Nuclear Soclety, San Francisco, Proc. 4ner. Nucl. Soc. 22, 112, 1975

Jones RH, 1 Lidofsky, TF Budinger, and P Weber. Quant l ta t l ve Nuclear Cardlo f a h , JN Pierson Jr., JP KrIss, RH Jones, and WJ RacIntyre, e d m d l l e y and Sons, pp 231-253, 1975.

Budinaer TF and GT Gullbera. Reconstruct ion bv two-dlmenslonal f i l t e r i n a o f

General theory f o r imgrovement o f s lmple superpos l t lon

I n s t r u m n t a t l o n , in ,

s l m p l i superpos i t ion t r a n s i e r s e sec t i on image,- i n , Ima e Processin fo r -2% and 3-D Reconstruct lon from Pro 'ec t i ons Theor and ++ r a c t i c e i n c i n e = the ~ h s 7 c a l k i e n c e s , KY- d y ~ h e r i c a and ktiana~ m e h d m p T h A9- 1 -T hA9 - 4, 1 9 7 5 .

Budfnger TF, and B Hacdonald. Reconstruct ion of t h e Fresnel coded gamna camera image by d i g i t a l computer, J . Nucl. Med. 16, 309-313, 1975.

HcGinnls J, R Cassou, EV Benton, TF Budinger and BR Hoyer. temperature on the l a t e n t t rack fading r a t e i n AgCl (cadmium doped) c r y s t a l detectors, LRL Report No. 2043, Feb, 1975.

Budinger TF. Three-Dimensional imaging of t he myocardium w i t h isotopes, i n Vol. 72 - Cardlovascular Ima i n and Ima e Processln Theor and Prac t ice m,% Harr ison, H Sand&dx d r & o d e g s t a t e s , m f o r n l a , Soclety o f Photo-Optical Ins t rumenta t ion Engineers, pp 263-271, 1975.

Budlnger TF, KH Crowe, JL Cahoon, VP E l i scher , RH Huesman, and LL Kanstetn. Transverse sec t i on imaging w i t h heavy charged p a r t i c l e s : Theory and

The e f f e c t o f

app l i ca t i ons .

~ a d e ~ o ~ a ~ n d Pro 'ec t ions Theor d r d M e d i c i n e Na t i o n a n c G c % % t h M A L the

Rudlnger TF, CA Toblas, RH Huesman, FT Upham, TF Wieskamp and R A Hoffman, Apollo-Soyuz l i g h t f l a s h observattons. Presented a t COSPAR Conference, Ph l lade lph ia , June 1976.

Budinger TF. Presented a t FASEB Symposium, Anahefm, C a l i f o r n i a , A p r i l 12, 1976 (Also Lawrence Berkeley Laboratory Report No. LBL-5605). 1976.

Budinger TF. D i g i t a l image processtng fo r medtcal diagnoses us ing gamna rad ionuc l ides and heavy ions from cyc lo t rons . I n Df i t a 1 Processin of B i o m e d i c a l Ima es (K. Preston, Jr. and H. Onoe, E - k i l d s m n g tompany , 19769-

Budinger TF, Tobias CA, Huesman RH, Upham FT, and Wieskamp TF: L igh t f l ash observat lons du r ing Apollo-Soyuz. I n te rna t tona l As t ronaut ica l Federation X X V I I Congress, Anaheim, C a l i f o r n f a , October 10-16, 1976, I A F Paper 76-032, 8p., 1976

I N , Ima e Processin for 2-D and 3-0 Reconstruct ion from ences, (New - 1 t o

NAL-4, 1975.

Current and fu tu re app l i ca t i ons of recons t ruc t i on techniques.

T. F. Budlnger Cur r icu lum Vf tae Page 8

Hoop B Jr., TF Budlnger, JW Banes, e t al. Hyocardlal p o s i t r o n sc in t ig raphy w i t h s h o r t - l i v e d 8%b. IEEE Trans. k c l . kf. NS-23, 584-589, 1976.

Budlnger TF, Tobfas CA, Schopper E , Schott JU, Huesman RH, Upham FT, Wieskamp TF. Kucala Jn. Gouldlna FS. and Landis DA: P u a n t i t a t l v e observat ion o f l i g h t f l i s h sensat ions - E x p j r i G n t MA-106. A 0110-So UT Test Pro jec t , Prel iminary Science ReDort. NASA TM X-58173. 18. + - . - - _ -

Budlnger TF, GT Gullberg, 8R Moyer, JL Cahoon, and RH Huesman, Transverse sec t i on Imaging o f t he myocardiun. o f Nuclear Medicine, Dal las. J Nucl Med 17:552 (abs t rac t ) 1976

Budinger TF, Tobias CA, Huesman RH, Upham FT, Wieskamp TF, and Hoffman RA: Apollo-Soyuz l i g h t f l a s h observations. XV, Proceedings o f t h e 19th p lenary m e e t l n g r C o s p a r , P h n & a m n e 8-7, 1976. Pergamon Press, Oxford, pp 141-146, 1977.

Budinger TF, JL L in foo t , BR Fbyer, JT Lyman and JL P e l l e t l e r . w f t h heavy-ions. -I- Ions a t the Bevalac, 1 9 h a p t e ~ B ~ l ~

Presented a t 23rd Annual Meeting, Society

I n L l f e Scfencer and S ace Research

Bra in research IN, R i o l o i c a l and Medical Research w i t h Accelerated Heavy

Yano Y, TF Budinger. pancreas scanning agent as a 6 ? h amino a c i d chelate. J. Nucl. Med.

Cyclotron-produced Zinc-62: A poss ib le p ros ta te and

18(8):815-821, 1977. - Oerenzo SE, PG Banchero, JL Cahoon, RH Huesman, T Vulet ich, and TF Budinger. Design and cons t ruc t i on o f the Donner-280 c r y s t a l p o s l t r o n r i n g for dynamic t ransverse sec t i on emfssion imaging. dec i s ion and Control . Vol. 1, pp 341-349. 177CH1269-OCS. 1977.

Budinger TF, SE Derenzo, GT Gullberg, WL Greenberg, and RH Huesman. E m i s s i o n computer ass i s ted tomography w i t h s ingle-photon and p o s i t r o n a n n i h i l a t f o n photon emi t te rs . J . Comput. Assist . Tomogr 1(1):131-145, 1977.

Huesman RH, C r o w KM, and Rudinger TF: Heavy charged p a r t i c l e s versus photons i n computer ass i s ted tomography: theory and experiment, J Comput A s s i s t Tomogr 1 ( 2 ) : 265, (Abs t rac t ) 1977.

Derenzo SE. TF Budinaer. JL Cahoon. RH Huesman. and HG Jackson. High

In Proe. o f t h e 1977 IEEE Conf. on

resolut ion-computed iomography o f p o s i t r o n emf t te rs . IEEE Trans Nucl Sci NS-24(11:554-55%. 1977.

Budinger TF. Ins t rumenta t ion t rends i n nuc lear medicine. I n Seminars 2 Nuclear k d l c l n e , 1:285-297, October, 1977.

Budinger TF, Tobias CA, Huesman RH, Upham FT, Uleskamp TF, Schott JU, and Schopper E: L i g h t f l a s h observat ions - Experiment MA-106. P ro jec t - Summary Science Report, NASA SP-41.2. pp 193-209,

Budlnger TF, R t l Glaeser. e l e c t r o n microscope o b j e c t i v e lens. U1 t ramicroscopy 2:31-41, 1977.

A 0110-So uz Test

Measurement o f focus and spher tca l aberrat ion o f a n

Budinger TF, FD Rol lo. Physics and instrumentat ion. I n Progress i n Card iovascular Diseases, Vol. XX, No. 1, pp. 19-53, 1977.

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Yano Y, P Chu, TF Budinger, PM Grant, A€ Ogard, JU Barnes, HA O'Brien, and B. Hoop. Rubldium-82 generators f o r imaging studies. J. Nucl Med. 18(1):46-50, 1977.

A tk lns HL, TF Budlnger, E Lebowlt t , AN Ansarl, MI Green, and R Fa i r ch i l d . Thal l lum-201 f o r medlcal use. 111: Human d l s t r l b u t l o n and phys ica l imaging proper t ies . - Med 18(2):133-140, 1977.

Rrookhaven Nat iona l Laboratory Report No. BNL-20910 and -- J. Nucl.

Budinger TF, JL Cahoon, SE Derenzo, GT Gul lberg, BR Moyer, and Y Yano. Three dlmensional imaging o f t he myocardium w i t h rad ionuc l ides . Radlology - 125~433-439, 1977.

Budinger TF, and GT Gul lberg. e m i t t i n g rad ionuc l i des i n pa t i en ts . I n Reconstruct fan Tomo r a h i n D i a n o s t i c Radiolo and Nuclear Medicine (M. Ter-Pogoss e e v s , an Gordon k e d e s . ) U m t y r e s s , pp. 315-342, 1977.

Huesman RH, GT Gullberg, WL Greenberg, and TF Budinger. Users Manual - Donner Algoralthms fo r Reconstruct ion Tomography. Lawrence Berkeley Laboratory Pub l l ca t l on PUB-214, 1977.

Sargent TS, TF Budinger, G Braun, AT Shulgin, and U Braun. An iod ina ted catecholamine congener f o r b r a i n imaging and metabol ic studies. J. Nucl. Med.

Sargent T, TF Budinger, G Braun, AT Shulgin, and U Rraun. An iod ina ted catecholamine congener f o r b r a i n imaging and metabo l ic studies. J Nucl Med

Sargent T5, 6 Braun, U Braun, TF Budinger and A Shulgin. R ra in and r e t i n a uptake o f rad io - l od lne labe led psychotomimetic i n dog and monkey. Comnunications 71 Psychopharmacology, m:l-lO, 1978.

P e l l e t i e r JL, BR Moyer and TF Budinger. l e s i o n s i n dogs by a 2 mn heavy-ion c y c l o t r o n beam. Laboratory, U n i v e r s i t y o f C a l f f o r n i a , Berkeley, C a l i f o r n i a , LBL-7401, 1978.

.Rudlnger TF, P Wong and C-K Yen. Epidemiological study design, Laurence Berkeley Laboratory Report 8319, October 1978.

Budinger TF, WL Greenberg, SE Derenzo, GT Gul lberg, and RH Huesman. Q u a n t i t a t i v e p o t e n t i a l s o f dynamlc emission computed tomography. J. Nucl. Med.

P e l l e t i e r JL, F Guignier, C Tourery, BR Moyer and TF Budinger. Radioimnunoassay of t hy ro t rop in - re leas ing hormone I n serum and i t s app l i ca t i on i n dogs w i t h hypothalmic les lons . I n t e r n a t i o n a l Conf, Washington, DC, S e p t e i n b e r , T 7 8 . --

Transverse sec t l on recons t ruc t i on o f g a m - r a y

19(1):71-76, 1978.

- 19~71-76, 1978.

E f fec ts o f hypothalamic radio-induced Laurence Berkeley

Magnetic f i e l d e f fec ts on humans:

- 19(3):309-315, 1978.

IN , Uor ld Fed Nucl Hed Proc, h d

3 0 0 b 9 0 3

T. F. Budinger Curr iculum V i tae Page 10

P e l l e t i e r JL, BR Moyer and TF Budinger. Technetium-9% labe led thy ro t rop in - re leas ing hormone (TRH) i n dogs w i t h and w i thou t a n t e r i o r hypothalamic les ions , Laurence Rerkeley Laboratory, U n i v e r s l t y of Ca l i f o rn ia , Berkeley, CA, LBL-7402, 1978. Tsui E, and TF Budlnger, Transverse sec t i on imaging of mean clearance time. L-- Ph s Med B i O l 23(4b644-653, 1978.

Tsui ET, and TF Budinger. A s tochas t i c f i l t e r f o r t ransverse sec t i on recons t ruc t ion . IEEE Trans. Nucl . ki NS-26(2):2687-2690, 1979.

Budinger TF. Computed tomography: Three dimensional imaglng w i t h photons and nuc lear magnetic resonance. Processin , KF Fu, T P a v l i d i s (eds.). B e r l i n - h n T d e r l a g 4". 0-6940 Ueinheim, pp 179-212, 1979.

Budinger TF, GT Gullberg, and RH Huesman.

In Biomedlcal Pa t te rn Reco n i t i o n and Ima e

Emission conputed tomography. I n App l ica t ions ed. by

erman.

Yano Y, TF Budinger, HA O'Brien, Jr., and PM Grant. Eva lua t ion and app l i ca t i on o f alumina column Rb-82 generators. J. Nucl. Med. 20(623684, (abs t rac t ) , 1979.

Budiger TF, and G f Gullberg. a t tenua t ion compensation i n ECT. J. Nucl. Med. 20(6):658, (abs t rac t ) , 1979.

Budinger TF, Y Yano, SE Derenro RH Huesman, JL Cahoon, BR Moyer, WL Greenberg, and HA Obrien, Jr. tomography. J. Nucl . Med. 20(6):603, (abs t rac t ) , 1979.

Budinger TF. Physics and physiology o f nuc lear cardiology. I n Nuclear Cardiology, ed. by JT Wil lerson.

Derenzo SE, TF Budinger, JL Cahoon, WL Greenberg, RH Huesman and T Vu le t i ch , The Oonner 280-crystal h igh r e s o l u t i o n p o s i t r o n tomograph. I E E E Trans. Nucl. - Sci. NS-26(2):2790-2793, 1979.

Derenzo 'SE, Rudinger TF, Cahoon JL, Greenberg WL, Huesman RH, and Vu le t i ch T: The Donner Laboratory 280-crystal h igh r e s o l u t i o n pos i t ron coincidence tomograph. I n Proceedings of t he 5 th I n t e r n a t i o n a l Conference on Posi t ron Ann ih i l a t i on , Sendaf, Japan, The Japan I n s t i t u t e o f Metals, pp 409-411, 1979.

Budinger TF. Thresholds f o r phys io log i ca l e f f e c t s due t o RF and magnet ic f i e l d s used i n NMR imaglng. I E E E Trans. Nucl. Sci. NS 26(2):2821-2825, 1979.

Budinger TF, SE Derenzo, GT Gu l lberg and RH Huesman. Trends and prospects f o r c i r c u l a r r i n g p o s i t r o n cameras. I E E E Trans. Nucl. ki. NS-26(2):2742-2745. 1979.

Rudinger TF, SE Derenzo, RH Huesman, J L Cahoon, and Y Yano. Dynamic e m i s s i o n t r a n s a x i a l tomography fo r p o s i t r o n emi t te rs . I n F r o n t i e r s i n Nuclear Medicine, W Horst, HN Wagner, Jr., and J Buchanan ( e d s ) . r n n - --Verlag, pp 52-70, 1980.

L i m i t a t f o n s of t he simple geometric mean f o r

Myocardial uptake o f rubidium-82 us lng p o s i t r o n emission

FA Davis 6 Co., Phi ladelphia, p p m l 9 7 9 .

OOCUMENT SOURCE h r r n c r B u k o l q Labofrlofy kChlvO8 Md flKOrd8 o f k 4

T. F. Budinger Curr icu lum V i t a e Page 11

Budinger TF, Y Yano, SE Derenm, RH Huesman, C-K Yen, BR Fkyer, and LG Sherman. I n f a r c t t o n s i t i n g and myocardial per fuston measurements u s l n g Rubid ium42 and p o s i t r o n emfssion tomography. h e r . J. Card io l , 5 : 3 9 9 , 1980.

Budtnger TF. Mul t i -d imensional space and t ime s i g n a l p roce ts fng i n b io logy and medicine. Proceedin s IEEE I n t e r n a t t o n a l Symposium 0" C i r c u t t s and Systems, 2, d l v ~ 6 ; .

Budinger TF. Phys ica l a t t r l b u t e s of s i n g l e photon tomography. --- 3. Nucl. Med. - 21:579-592, 1980.

Yano Y, J Cahoon, and TF Budinger. P r e c i s i o n f l o w - c o n t r o l l e d Rb-82 generator f o r bo lus and constant in fus ion . *I, Nucl. Med. 21(6):P85, (Abs t rac t ) , 1980.

Budinger TF, SE Derenzo, RH Huesman, LG Sherman, BR Moyer, and Y Yano. Q u a n t i t a t i v e myocardial f l o w - e x t r a c t i o n data u s i n g gated ECT. - 21(6):P16, (Abs t rac t ) , 1980.

Budinger TF, SE Derenzo, and RH Huesman. rad ionuc l ide d i s t r t b u t i o n and k i n e t i c data. Presented a t t h e I n t e r n a t t o n a l Rad iophanacuet tca l Dosimetry Symposium, Oak Ridge, Tennessee, October 7-10, 1980. Laurence Berkeley Laboratory Report, LRL 111649, 1980.

Budtnger TF. S i n g l e photon emiss ion tomography. In: Current Develo ments i n Medical Ima i n - An Evaluat ion. Proceedings o f a s p p o ~ h o - m , d & d o , ~ u g u * t 5-7, pp 81-101, 1980.

Venkatesh N, TF Budinger, and C-T Peng. Whole body autoradtography: A procedure f o r e v a l u a t i o n o f radiopharrnaceuticals. J . Nucl. Med. 21(6):P78, (Abst ract ) 1980.

Yano Y, JL Cahoon, and TF Budinger. generator f o r bo lus and constant i n f u s i o n s tud ies of t h e h e a r t and bra in . 3-

Rudinger TF, C-K Yen, Y Yano, RP Fr ied land, and HA O'Rrien, Jr. b a r r i e r p e r m e a b i l i t y and i n t r a v a s c u l a r f l w - v o l u m e measurements u s i n g Rubidium-82 and dynamic p o s i t r o n tomography. J. Nucl. Med. 22: P-15-Pl6, (Abs t rac t ) , 1981.

Budinger TF. imagtng. Presented a t NATO Advanced Stud I n s t i t u t e (ASI) on Diagnost ic Imaginp & Medicine, S a n m i m d t . 11-23, 198T. - Gaffey CT, T S Tenforde, TF Rudinger, and BR Moyer. E lect rocard iogram and blood pressure measurements on monkeys d u r i n g exposure t o s t a t i o n a r y magnetic f i e l d s .

Washington, D.D., 4ugust 9-12, 1981.

Yen C-K, and TF Budinger. Eva lua t ion o f b lood-bra in b a r r i e r permeab i l i t y changes i n Rhesus monkeys and man u s i n g E2Rb and p o s i t r o n emission tomography. 3. Comput. Assts t . Tomogr. 5:792-799, 1981.

--- J. Nucl. Med.

Role o f tomography f s p r o v i d i n g

A p r e c i s i o n f l o w - c o n t r o l l e d Rb-82

NuCl Med. 22:1006-1010, 1981. --- Alood b r a i n

Current s t a t u s and l i m i t a t i o n s o f s i n g l e photon emission

Presented a t the 3rd Annual Conference o f t h e Bioe lect romagnet ics Society,

-

I WCUUENT SOURCE Lrvrrrncr Bwtrlw Labornlw

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T. F. Budinger Curr icu lum V i t a e Page 12

Derenzo SE, TF Budinger, RH Huesman, JL Cahoon, and T Vulet ich. p r o p e r t l e s o f a p o s i t r o n tomograph with 280 BGO Crysta ls . IEEE Trans. Nucl.

Imaging

- S C ~ . NS-28(11:81-89, 1981.

Huesman RH, SE Derenro, GT Gullberg, and TF Budinger. Novel two-pos i t ion sampling scheme f o r dynamic emission tomography. J. Nucl. Ned. 22:P38-P39, (Abst ract ) , 1981.

Budinger TF. Nuclear magnetic resonance (NHR) i n v i v o s tud ies: Known th resho lds f o r h e a l t h effects. J. Comput Ass is t . Tomogr. 5:BOO-811, 1981.

Budinger TF. Overview o f Imaging technologies: Present and f u t u r e trends. Presented a t US-Ita1 J o i n t S m on Methods of Noninvasive Dia nos is i n

8udinger TF. Phys ica l and medical a t t r i b u t e s of s i x contemporary noninvasive imaging techniques. D i g i t a l Radiography Proc. S.P.I.E. =:9-17, 1981.

Budinger TF. Phys ica l a t t r i b u t e s o f s i n g l e photon tomography. In : Emission Cam u ted Tarno r a h The Sin l e Photon A roach, P. Paras, EA Eikman, '(eds).- &t-&?&& and &S-s%nd Drug Admin is t ra t ion , Bureau of Rad io log ica l Health, Rockv i l le , Maryland HHS P u b l i c a t i o n FDA 81-8177,

Budinaer TF. P o t e n t i a l medical e f f e c t s and hazards o f human NMR studies.

Card iovascular + 9 i s e a s e m e s a,m=n%ess, NY, No V*9E.

August, pp. 6-25, 1981.

I n : & c l e a r Ha n e t i c Resonance Ima i n i n Mediclne, L. Kaufman, LE Crooks, and A M a F C h a k u -Shoi n, Ipp9 ew ork7p-1, 1981.

Budinger TF, E Ganr, DC Pr ice, b! Lipton, RR Moyer, Y Yano. nuc lear magnetic resonance methods o f eva lua t ing a therosc le ros is . Presented a t Workshop on O u a n t i t a t i v e Eva lua t ion Atherosc leros is , S i l v e r Springs, MD., Spr inger-VerEg, NY, Feb 22-23, 1981.

Fr ied land R, Rudinger TF, Yano Y, Huesman RH, K n i t t e l B, k r e n z o SE, Koss B and Ober BA: Regional cerebra l metabol ic a l t e r a t l o n s I n Alzheimer-type dementia: Studies w i t h 19-deoxyglucose. I X I n t e r n a t i o n a l Symp. on Cerebral Blood F1 ow and Metabolism, Par is , France, Junr 20-24, ( a b s t r a c t ) 1981.

Radionucl ide and

Budinger TF. Reviva l o f c l i n i c a l nuc lear medicine b r a i n imaging. J. Nucl. -- Med. 22:1094-1097, 1981.

Gu l lberg GT, and TF Budinger. constant a t t e n u a t i o n i n s ing le-photon emission computed tomography. Trans. Biomed. BME-28(2):142-157, 1981.

Huesman RH, Derenzo SE, and Budinger TF: Two-posit ion sampling f o r p o s i t r o n emission tomography. San Francisco, C a l I f o r n i a , October 21-23, 1981.

Huesman RH, Derenzo SE, and Budinger TF: A two-pos i t ion samplfng scheme f o r p o s i t r o n emiss ion tomography. I n Nuclear Medicine and B i o l o Proceedings o f t h e T h i r d World Congress o f N u c l e ~ c ~ ! 3 ~ o d u s t 29-September 2, Par is , France. Ual. I, pp 542-545, 1982.

-- The use o f f i l t e r i n g methods t o compensate f o r

-- Presented a t t h e IEEE 1981 Nuclear Science Symposium,

I DOCUMENT SOURCE I

T. F. Budinger

Page 13 - Curr iculum Vi tae

Yen CK, Y Yano, TF Budinger, RP Fr iedland, SE Derenro, RH Huesman. tumor eva lua t i on us tng Rb-82 and p o s i t r o n emisslon tomography. J. Nucl. Med.

B ra in

23:532-537, 1982. - Derenzo SE, TF Budinger, RH Huesman, JL Cahoon. wnamic p o s i t r o n emission tomography i n man us ing small bismuth germanate c rys ta l s . Ahh ih i l a t l on , PG Coleman, SC S h a m , LM Diana, eds. t o , New Yort, pp 935-945, 1982.

Budinger TF. and nuclear magnetic resonance methods o f measuring phys io log i c parameters, Presented a t t h e Ear l H. Wood Symposium, Hayo C l i n i c , Rochester, Minnesota, August 28-29, 1981. Mayo C l i n Proc 57(supplement):67-77, Ju ly , 1982.

In: Posi t ron North-Holland Pub1 i s h i n g

Oynamic t ransmfss ion computed tomography, emission tomography,

Budinger TF. Emission tomography: an overview o f Instrument l i m i t a t i o n s and p o t e n t i a l s . In, Noninvaslve Technl ues f o r Assessment of Atherosclerosis fi Per i he ra l , Carot id , and C o r o n & e v F Budinger,TS Berson, I . &t@ Hock, J n a d m e d s . , Raven Press, N.Y., pp 154-179, 1982.'

Rudinger TF. Medicine 10(12):835-840, 1982.

Image ana lys i s i n c r i t l c a l care medicine. C r i t i c a l - Care

Budinger TF. Medical app l i ca t i ons o f NMR scanning: kme perspect ives i n r e l a t i o n t o o the r techniques. Par ta in , edr. Proceedings o f an I n t ~ a & S y m p o s l m on Nuclear Magnetic Resonance Imaging. Winston-Salem, North Carol lna, pp. 51-64, 1982.

Budinger TF, SE Derento, RH Huesman, JL Cahoon. design o f a dynamic p o s i t r o n tomograph f o r hear t studles. I E E E 1981 Nuclear Science Symposium, San Francisco, C a l i f o r n i a , October 21-23, 1981. - IEEE - Trans. - Nucl. - Scl. NS-29(1):488-492,

In : NW Ima i n , RL Ui tco fsk i , N Karstaedt, CL

Bowman Gray School o f Medicine o f Wake Forest Univers i ty ,

Medical c r i t e r i a f o r the

1982.

Presented a t the

Rudinger TF, Derenzo SE, Huesman RH and Cahoon J: Medical c r i t e r i a fo r the design o f a dynamic p o s i t r o n tomograph f o r hear t studies. I E E E Trans Nucl S c i NS-29: NO 1, 488-492, 1982. P

Rudinger TF. Nuclear magnetic resonance i n the study of a therosc leros is . In, Noninvasive Techni ues f o r Assessment of Atherosc leros ls i n Per i heral t a r o t o r & r G , ud i nger, erson, n z v d k , d n % S w n v e : F P : e s s , NY, !51-154, '1!:2.

Budinger TF, BJ &Nei l , PO Alderson. pulmonary studies. J . Nucl Med. 23:60-65, 1982.

Budinger TF, Yano Y , Hoyer BR, Mathis CH, Ganz E, Huesman RH and Derenzo S E . Pos i t ron Emission Tomography o f the Heart. Proceedings o f t he Thi rd World Congress of N u c l e m c j n e and 8mogy. August 29-September 2, Par is , France. vbl . 111, pp 2338-2341, 1982.

Perspect ives i n nuclear medicine:

Jn Nuclear Medicine and B i o l o g y .

3 0 0 b 9 0 7

1. F. Budinger Curr iculum V i tae Page 14

Budinger TF, Yano Y, Huesman RH, Oerenzo SE, Hoyer BR, Mathis CA, Ganr E, and K n i t t e l B: Pos i t ron emission tonography of the heart . 26, pp 31-34, 1983, presented at, 33rd Ann. F a l l Meeting 0f-e- Phys lo log ica l Soclety, San Diego, CA, Oct. 10-15, 1982.

Budinser TF. SE Derenzo. RH Huesman. JL Cahoon. Pos l t ron emission tomoaraahv:

The Ph s i o l o 1s t

i ns t r imen ta t i on perspect ives. Proceedin s o f the I n t e r n a t f o n a l Uorksho - i n * Ph s i cs and En i n e e r i n f n M e d l c d m n r e r e n c e a t F a d o X , b n F 1 - TEE-*: 3-13, 1982.

Brownell GL, TF Budinger, PC Lauterbur, and PL kGeer . nuclear magnetic resonance imaging. Science 215:619-626, 1982.

Pos l t ron tomography and

Budinger TF. Preface: Ins t rumenta t ion f o r imaglng receptor b ind ing s i t es . In: Rece t o r B i n d i n F l o r k 8 d B Z .

Radiotracers, Vol. 11, WC Eckelman, ed. CRC Press,

Davis J, Y Yano, J Cahoon, and TF Budinger. and L-[S-methyl- l'c] methionine by an automated cont inuous f l o w process. J. Appl. Radiat. I so t . 33:363-369, 1982.

Yano Y, and TF Budlnger. Shor t - l i ved pos i t ron e m i t t e r s from rad io lso toPe

Prepara t ion o f lk -Methy l i od ide I n t . - - ---

generators. In: Fourth I n t e r n a t i o n a l . S osium on Radiopharmacuetical' Chemistrx, KFA J u l i u g u s t 23-27, pp *,-138Z.

Huesman RH, SE Derenzo, and TF fludinger. A two-pos i t ion sampling scheme f o r p o s i t r o n etnlrs ion tomography. ed., Pergarmon Press, New York, VolI,542-545,3.

Budinger TF and C Cullander. v i v o magnetic resonance.

1983.

I n Nuclear medicine and Biolo%, Raynaud C.,

B i o l o g i c a l phenomena and hea l th hazards of i n C l i n l c a l Ma n e t l c Resonance Ima i n , AR Hargu l i s e t

a i , ed. Radiology Research X T E l i Z a d i i - E n d a t l m ; San 7es rancisco: 303-321,

Tenforde TS, CT Gaffey, BR Hoyer and TF Budinger. i n Macaca monkeys exposed t o s ta t i ona ry magnetic f i e l d s : Experimental observat ions and t h e o r e t l c a l analysis, Bioelectronmagnetlcs 4, 1-9,

Card iovascular a l t e r a t i o n s

1983.

Krohn KA, Y Yano, TF Budinger, BR Moyer. produced isotopes, I s o t o e Generators i n Nuclear Medicine, American Chemical Socfety Meeting, d a s h , ngton, Seatm.,1983.

Derenro SE, TF Budinger and T Vulet lch. tomography us ing narrow bismuth germanate c r y s t a l s and i n d i v i d u a l photosensors.

Fr ied land RP, CA Mathis, TF Budlnger, BR Moyer.and H Rosen. and phosphorylchol ine: Body d i s t r i b u t l o n and b r a i n autoradiography: Concl se c o m n i c a t i o n , J. Nucl. Med. 24: 812-815, 1983.

Budinger TF, Y Yano, BR Moyer, JA Tw i t che l l , and R H Huesman e x t r a c t i o n o f Rb-82 vs. f l o w determined by pos i t ron emission tomography. C i r c u l a t i o n 68: 111-81, (Abs t rac t ) 1983.

Cryptate complexes o f generator Presented a t the Nuclear Chemistry and fechnoloqy Session,

High r e s o l u t i o n p o s i t r o n emission

I E E E Trans Nucl S c i NS-30: No 1, 665-670, 1983. ---- Labeled cho l ine

---- Myocardial

WCUMENT SOURCE Lnrtncr B u l ~ o l q W a l o r y kChlv.8 Md RUO& OIlicO

T. F. Budinger Curr lcu lom V i t a e Page 15

Budinger TF. NMR i n v i v o studies: a comparfson t o o t h e r noninvas ive imaging techniques. In: Nuclear Ma n e t i c Resonance (NMR) Ima I n CL Partain, AE James, FD Rol lo , R R m h 3aundcrs C ~ w d & p , 357-374, 1983.

Budinger TF. Nuclear magnetlc resonance and p o s i t r o n emiss ion tomography In: Cerebra l Vascular Dfsease, Re iv ich H, H I Hur t lg , eds. New York, Raven Press; -83.-

Budfnger TF. Presented a t t h e US-I ta ly J o i n t Symposium o f Methods o f Noninvaslve Diagnosis i n Card iovascular Disease, Rethesda, Maryland, November 12-13, 1981. In: Noninvasive Methods 2 Atherosc le ros is Research. RJ Hegyeli , (ed.), A t h e r o s c l e r o m i e w s , Vol 10, Raven York, pp 7-12, 1983.

Budinger TF, Y Yano, CA Hathis, JU Davis, RH Huesman, SE Derenro. emission tomography of the hear t . Symposium, Naples, I t a l y , September 21-23, 1981. In: Nuclear Cardiology. Plenum P u b l i s h i n g Corp., New York, pp. 229-248, 1983.

Budinger TF, Y Yano, RH Huesman, SE Derenzo, RR Moyer, CA Mathis, E Ganz, B K n i t t e l . P o s i t r o n emission tomography o f t h e hear t . Phys io log is t , 5:

F r i e d l a n d RP, TF Budinger, E Ganz, RH Huesman, SE Oerenzo, R K n l t t e l . Q u a n t i t a t i v e e v a l u a t i o n o f b lood b r a i n b a r r i e r i n t e g r i t y i n Alzheimer-type dementia: P o s i t r o n emision tomographic s tud ies w i t h Rubidium-82. Euro Neurol Vol 22, Suppl 2:19, 1983.

Robertson JS, RR Price, TF Budinger, VF Fairbanks, M Pol lycove. absorbed dose from Iron-52, iron-55, and i ron-59 used t o study f e r r o k i n e t i c s ,

Budinger TF, E Ganr, DC Pr ice, H Lipton, BR Moyer, and Y Yano. and nuc lear magnetic resonance methods o f e v a l u a t i n g a therosc le ros is . Presented a t t h e Workshop on Quant i ta t i ve Eva lua t ion o f A therosc le ros is , S i l v e r Spring, .Maryland, February 22-23, 1981. A therosc le ros is Quant i ta t i ve k t h o d s o f Evaluat ion, M% +Insul, Jr.. 5 Ragov, AB Ch and ler and F C o r m ( g s > , Springer-Verlag, New York. pp.

F r i e d l a n d RP, TF Budinger, Y Yano, RH Huesman, B K n i t t e l , SE Derenzo, R K o s s , BA Ober. Regional cerebra l metabol ic a l t e r a t i o n s i n Alrheimer-type dementla: K i n e t i c s t u d i e s w i t h 18-fluorodeoxyglucose. .I . Cereb. Blood Flow Metab. 3,

F r i e d l a n d RP, TF Budinger, E Ganz, Y Yano, CA Mathis, B Koss, 9A Oher, RH Huesman, and SE Derenzo. Regional cerebra l Metabo l ic a l t e r a t i o n s I n dementia o f the Al rhe imer type: Pos i t ron emission tomography w i th CleF]Fluoro- deoxyglucose, J. Comp. Ass is t . Tomogr. 7: 590-598, 1983.

Rudinger TF. T ime-o f - f l tgh t p o s i t r o n emission tomography: Status r e l a t i v e t o convent ional PET, J. Nucl. Med. 24: 73-78, 1983.

Overview o f imaging technologies: present and f u t u r e trends.

Pos i t ron Presented a t t h e F i r s t Naples Cardiology

31-34, 1983.

Radiat ion

J. Nucl. Med 24: 339-348, 1983. ---- Radionucl ide

In: C l f n i c a l Dia nos fs of

189-219, 1983.

Suppl. 1: 5510-511, 1983.

I . P . auoinger Curr iculum V i t a e Page 16

Yano Y , TF Budinger, JL Cahoon and RH Huesman. An automated Microprocessor-Control l ed Rb-82 Generator f o r Pos i t ron Emission Tomography Studies. American Chemical Society; 97-122. 1984.

Fr ied land RP, TF Budlnger, UJ Jagust, Y Yano, RH Huesman, BL K n i t t e l , E Koss, BA Ober. An te r io r -pos te r io r and l a t e r a l hemispheric a l t e r a t l o n s I n c o r t i c a l glucose utilization i n Alzheimer's disease. J . Nucl. Med, G:PSt, (Abst ract ) 1984.

Knapp FF, TA Bu t le r , eds. Radlonucl lde Generators. Washington, D.C.:

Budinger TF, KS B r i s t o l , C-K Yen, P Wong. B i o l o g i c a l Ef fects o f S t a t i c Magnetic F le lds . Proc. Magn. Reson. Ned. Th i rd Annual Meeting, p113, (Abs t rac t ) 1984.

Fr ied land RP, S Prusiner, W Jagust, and TF Budfnger. Bitemporal hypometabolism I n Creutzfeldt-Jacob dlsease: p o s i t r o n emission tomography w l t h 18F-2-fluorodeoxyglucose. J. Comp. Assist . Tomogr. 8(5):978-981, 1984.

Bruno MF, RH Huesman, SE Derenro and TF Budinger. Charac te r l za t i on o f Compton s c a t t e r i n g i n emission tomography. J. Nucl. Wd. 25:P14, (Abst ract ) 1984.

Budinger TF. T h i r d Annual Meeting, p l l 5 , (Abst ract ) 1984.

Krohn KA, JH Link, Y Yano, and TF Budlnger. Cryptate complexes o f generator produced isotopes fo r measurement o f b lood flow. J . Nucl. &d, 25:P119, (Abs t rac t ) 1984.

Eckleman WC, RC Reba, UJ Rzeszotarski, RE Gibson, T H i l l , BL Holman, T Budinger, 35 Conklin, R Eng, and MP Grfsson. External imaging o f cerebral muscar in ic ace ty l cho l i ne receptors. Science, 223:291-293, 1984.

Comparison o f NMR t o other modal i t ies . Proc. Magn. Reson. Hed.

Rudinger TF, C Cullander. Heal th e f fec ts of i n v i v o nuc lear magnetic resonance. I n Biomedlcal Ma n e t i c R e s o n a n c e m m e s , AR Margul is, (eds), Radfology Research and tducat -4-r on oundation, San Francisco, pp. 421-441, 1984.

Oerenzo SE, RH Hucsman, TF Budinger, JL Cahoon and T Vulet ich. Hfgh reso lu t i on p o s i t r o n emisison tomography us ing 3 mn wide bismuth germanate c rys ta l s . J. Nucl . Ked. 25: P46, (Abs t rac t ) 1984.

Budinger TF, SE Derenro, RH Huesman. tomography. Ann. Neurol . 15(suppl):S35-S43, 1984.

Budlnger TF, Y Yano, BR Hoyer, JA T u i t c h e l l , KJi Brennan, RH Huesman. Measurements o f myocardial f l ow vs. e x t r a c t i o n of rubldlum under varying phys io log i ca l condi t ions. J. Nucl. Ced. 25:P69, (Abst ract ) 1984.

Budinger TF, RH Huesman, BL K n i t t e l , JA Tw i t che l l , KH Brennan. pe r fus ion by dynamic p o s i t r o n emission tomography (PET) us ing ! I -15aater . (Abs t rac t ) J Nucl Hed 25:P69, (Abst ract ) 1984.

Budlnger TF, PC Lauterbur. studies. Science, 226:288-298, 1984.

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Richards T, TF Budinger, R Nun l i s t . imaging o f the r a t b r a i n i n v i v o with the surface c o i l . Hed. Th i rd Annual Meeting, (Abs t rac t ) p621, 1984.

Jones RM, T Richards, TF Rudinger. and aqueous metabo l i tes ex t rac ted from bra in . Annual Meeting, (Abs t rac t ) p395, 1984.

Richards T, TF Budinger, R Nun l i s t . spectroscopy us ing l i p i d and n-acety l aspar ta te peak c h a r a c t e r l s t i c s o f normal b ra in . Proc. Magn. Reson. Med. T h i r d Annual Meeting, p623, (Abs t rac t ) 1984.

Roos M , A Hasenfeld, MR Bendall , RH Huesman, TF Budlnger. . s p a t i a l s e n s i t i v i t y f o r n u l t i p l e pu lse sequences and s e l e c t i v e e x c i t a t i o n s i n inhomogeneous B1 f i e l d s . Proc. Magn. Reson. k d . T h i r d Annual Meeting, p632, (Abs t rac t ) 1984.

Budinger TF, C Cullander, R Bordow. Switched magnetic f i e l d th resho lds f o r the i nduc t i on o f magnetophosphenes. Proc. Magn. Reson. M d . T h l r d Annual Meeting, p118, (Abs t rac t ) 1984.

F r ied land RP, TF Budfnger, M Brant-Zawadskl, UJ Jagust. The d iagnos is o f Alzheimer-type dementia: A p re l im ina ry comparison of p o s i t r o n emission tomography and pro ton magnetic resonance. JAM 252:19, 2750-2752, 1984.

Mazoyer BH, Hucsman RH, Budinger TF, and K n i t t e l BL: A study o f f ac to rs t h a t a f f e c t t he p r e c l s i o n o f Compartmental model parameter es t ima t ion us ing dynamic p o s i t r o n emission tomography. LRL-19614, (submit ted f o r p u b l i c a t i o n ) 1985.

Fr ied land RP, TF Budlnger, E Koss, and BA Ober. An te r io r -pos te r io r an l a t e r a l hemispheric a l t e r a t i o n s i n c o r t i c a l glucose u t i l i z a t i o n . Neuroscience L e t t e r s 53:235-240, 1985.

Phase encoded pro ton spectroscopy and Proc. Magn. Reson.

Proton and carbon spectroscopy of l i p i d s Proc. Magn. Reton. Med. Th i rd

RF pu lse energy o p t l m i z a t l o n f o r proton

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Lawrence Berkeley Laboratory Report No.

Alzheimer's disease:

-- Gul lberg GT, RH Huesman, JA Malko, NJ Pelc and TF Budinger. An at tenuated pro jec to r -backpro jec tor f o r i t e r a t i v e SPECT recons t ruc t ion . Phys. Hed. B io l . Val. 30:8 799-816, 1985. -- Wesby G, R Hurd, T Richards, M L ip ton , M Hoseley, B K n i t t e l , C Higgfns, T Budinger. Changes i n w s c l e water proton resonance frequency w i t h Ischemic exercise. Proc. Soc. Hagn. Reson. Hed. Fourth Annual Meetfng, London, 19-23 August, p 825, (Abs t rac t ) 1985.

Oerenzo SE, TF Budinger, and RH Huesman. r k t e c t o r s f o r h igh r e s o l u t i o n dynamic PET. I n The Metabolism o f the Human Bra ln s tud led w i t h Pos l t ron Emlssion TomographyT. G r e i t t , e t ~ , d ~ a ~ r e s s , w Y o r k , 1985.

Mathis CA, TF Budlnger, T Sargent, AT Shulgin, HF Kung. 122I- labeled amines and diamines f o r b r a l n blood flow measurements in neuro log ic disorder. J. Nucl. Med. (Abs t rac t ) June, 1985.

Mathis CA, TF Budinger, T Sargent 111, AT Shulgin, Kung HF. Generator produced 1-122 labe led amines and diamines f o r b r a i n blood f l o w measurements i n neuro log ic disorders. J. Nucl. Med. 26:P105 (Abs t rac t ) 1985.

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Soulen RL, TF Budlnger, CB Higgins. Clagnctic resonance imaging of p ros the t ic h e a r t valves. Radiology =:705-707, 1985.

Jagust WJ, RP Fr led land, TF Budlnger, RH Hucsman, B K n l t t e l . Hethodologic f a c t o r s a f f e c t l n g PET measurements of glucose metabolism. Neurology 35 (Suppl 1):138, 1985.

F r i e d l a n d RP, WJ Jagust, TF Budinger, RH Huesman, B K n l t t e l . Methodological f a c t o r s a f f e c t l n g t h e accuracy o f metabol ic measurements I n PET s tud ies w i t h (18F)-2-Deoxy-D-Glucose (FOG). J. Cereb. Blood Flow and Pktab. 5:5609-5610, 1985.

------ F r i e d l a n d RP, A Brun, TF Budinger. Patho log lca l and p o s i t r o n emission tomographic c o r r e l a t i o n s l n A l the lmer 's disease. The Lancet I :228; 1985. --- Lawton M, TF Budinger. Proceedings, Soc. Magn. Reson. Med. Four th Annual b e t i n g , London, 19-23 August, p 1009, (Abs t rac t ) , 1985.

Phase-encoded, rap id, mul t ip le-echo (PERHE) Imaging.

Budinger TF, RH Huesman, B K n i t t e l , R Fr ied land, and SE Derenzo. modeljng o f dynamic measurements o f metabollsm us ing p o s i t r o n emission tomography. Emisslon T o m o g r a p K 'f. Gre l tz ,

Yano Y, KH Brennan, SN Ebbe, M Singh, BH Moyer, DA Carpenter, EM Hazoyer, CA Mathis, TF Budinger. P l a t e l e t l a b e l i n g and p o s l t r o n emisslon tomography i n the d e t e c t i o n o f s t t e s of vascular I n j u r y . J. Nucl. Med. 26:P21 (Abst ract ) 1985.

Phys io log ica l

I n The Metabollsm o f t h e Human Bra in s tud led wi th Posl t ron Raven m m o r k , .

F r l e d l a n d RP, TF Budinger, HJ Jagust, Y Yano, RH Huesman and B K n i t t e l . P o s i t r o n emisslon tomography and t h e b lood b r a i n b a r r i e r i n Alzheimer's disease. In : Cerebrovascular Diseases Pathopharmacology: Bra in Imaginp 2 Cerebrovascular Diseases. NA Lassen and J Cahn, (eds.), S. L i b b n r o t e x t , Rontrouge, F r a n c w e s s ) . 1985

J fgus t WJ, PR Fr ied land, TF Budinger. [ F]f luorodeoxyglucose d i f f e r e n t i a t e s normal pressure hydrocephalus from Alzheimer 's- type dementla. J. Neurol. Neurosurg. Psych., 48: ( I n press) 1985.

Pos i t ron emisslon tomography w l t h

Fr led land RP, TF Budinger, UJ Jagust, E KOSS, S Derenro, RH Huesman and Y Yano.

Alzheimer's disease.

Budlnger TF, UK Doyle, VA Levln, PH Gutln. nervous system s t u d l e d by PET. J. Nucl. Med. 26:P24 (Abs t rac t ) 1985.

Budingcr TF, W Pavl icek, DO Faul, AW Guy. p r o t o n MR imaging. Proceedings, Soc. Hagn. Rtson. k d . Four th Annual Meeting, London, 19-23 August, p 916, (Abst ract ) . 1985.

P o s i t r o n tomography and t h e d i f f e r e n t f a l d iagnosis and pathophysiology of I n : A i n of the Brain, J. Traber and W. Gispen,

Spr inger-Ver lag Co., Heidel $9 e r g (5 pres-985.

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T. F. Budinger Curr icu lum V i tae Page 19

t la th fs CA, T Sargent I 1 , AT Shulgin, Y Yano , TF Budfnger, H Lagunas-Solar. Synthesis and eva lua t i on of meta-subs t i tu ted I-122-labeled dimethoxy-N,N-dimethylamphet%es f o r b r a i n fnaging studies. J. k c l . I 4 d . 26:P69 (Abs t rac t ) 1985.

Budinger TF, and RH Huesman. Ten precepts f o r q u a n t l t a t i v e data acqu ls i t l on and analysts. C i r c u l a t i o n 72 Suppl. I V , ( I n press) November 1985.

Budinger TF, B K n i t t e l , P Bruner, C Harrison. Tissue pe r fus lon phantom f o r p ro ton magnetic resonance f l o w studies. Proceedlngs, Soc. Hagn. Reson. Heed. Fourth Annual Heetlng, London, 19-23 August, p 577, (Abs t rac t )

Budinger TF. Uses of p o s i t r o n emission tomography f o r Alzheimer 's disease, stroke, and tumor therapy. Trans. h r . Nucl. Soc. 50:32, 1985.

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1985.

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