26 December 2016

IITM develops Asia’s first ‘lifesaving’ implantSynkroScaff

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IIT-M develops Asia’s first ‘life-saving’ implant SynkroScaff

NEW DELHI DEC. 26 (ENA) IITM has to its credit yetanother feat in that it has indigenously developed Asia’sfirst ‘lifesaving’ implant and named it SynkroScaff —ATissue Engineered Bovine Pericardial Patch — for criticalcardiovascular patients.

This technology which has a global demand is beingcommercially exploited by Chennaibased firm SynkroMaxBiotech (SMBPL).

The unique feature of this pericardial patch is that it hasinborn properties of regeneration and integration in thebody.

The ones that are in use in India are processed usingsynthetic material and toxic chemicals but the product IITM has come up with uses biomaterial.

IITM’s professor and director of SMBPL, SomaGuhathakurta, said that it had the potential to revolutionisethe field of surgical patches with products designed andmade in India.

There are two advantages, first, India’s dependence on imports will be eliminated and secondly, patients will not haveto undergo a second procedure to remove the sack after usage.

The interesting part is that using indigenous technology originally emerged out of Guthakurtha’s doctoral research inIITM in 2004 under the supervision of Prof. Venkatesh Balasubramanian, Department of Engineering Design.

According to her, the product can be used to achieve anatomical correction of the heart and its blood vessels’deformities and deficiencies.

“Its applications are immense in cardiovascular and other surgical practices. We obtained the licence for the productin May this year. So far, 800 patches have been manufactured and over 12 surgeons are using them across India.Apollo Hospitals, Kauvery Hospital in Chennai and AIIMS in Delhi are using it.

Guhathakurta’s mentor, Venkatesh Balasubramanian, said, “It is always a desire that the philosophical work done asa doctoral thesis is inventive and innovative. This was possible by an innovative processing of xenogeneic tissue forhuman usage.

“While the doctoral work won the best thesis award from Indian National Science Academy (INSA) in 2008, the truevictory is when it is available as a surgical patch for the world, made in India.

“It is a pleasure that Soma Guhathakurtha and SMBPL are taking this technology to offer SynkroScaff, a productconceived, researched, designed, developed and made in India, for the world.” Balasubramanian said the cost ofimported material — between `30,000 and `35,000 — would be slashed by half using Indiamade implants.

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IITM’s ‘lifesaving’ implant makes its way to the marketsBy Express News Service | Published: 26th December 2016 02:25 AM | Last Updated: 26th December 2016 04:40 AM | A+ A A |

Finding it difficult to detect fake versus genuine sales visits?Medisafe, a small business, did this instantly! Watch now.SPONSORED BY

CHENNAI: In a significant breakthrough, researchers at the Indian Institute of Technology, Madras (IITM) have indigenously developed Asia’s first ‘lifesaving’ implant called SynkroScaff — A TissueEngineered Bovine Pericardial Patch — for critical cardiovascular patients. Now, the technology, whichhas a global market, is being commercially exploited by a Chennaibased firm SynkroMax Biotech(SMBPL), for which a memorandum of understanding was signed last month.

The distinctive feature of the IITM pericardial patch (sack of buffalo’s heart) is that it has inherentproperties of regeneration and integration in the body. While the existing ones used in India areprocessed using synthetic material and toxic chemicals, which can lead to calcification, the product IITM came up with uses biomaterial. Currently, India depends on imported surgical patches.Soma Guhathakurta, IITM adjunct professor and director of SMBPL, said it had the potential torevolutionise the field of surgical patches with products designed and made in India. This has twinadvantages. One, India’s dependence on imports will be eliminated and two, patients don’t have toundergo a second procedure to remove the sack after usage. None of the synthetic, homologous(humanderived) and xenogeneic (compatible animalderived) patches have potential for growth andrepair requiring reoperations.

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Interestingly, development of SynkroScaff using indigenous technology originally sprouted out ofGuhathakurta’s doctoral research in IITM in 2004, under the guidance of Venkatesh Balasubramanian,professor, Department of Engineering Design. She claims that the product has got versatile use toachieve anatomical correction of the heart and its blood vessels’ deformities and deficiencies. “Itsapplications are immense in cardiovascular and other surgical practices. We obtained the licence forthe product in May this year. So far, 800 patches have been manufactured and over 12 surgeons areusing them across India. Apollo Hospitals, Kauvery Hospital in Chennai and AIIMS in Delhi are using it.We have also enrolled for Central Medical Services Society (CMSS) recognition of the product. Thefeedback from doctors and patients has been encouraging, with a 100 per cent success rate,” she said,adding that the product is manufactured in a facility complying with drug applications and current goodmanufacturing practice (cGMP) guidelines.

Venkatesh Balasubramanian, who mentored Guhathakurta, said, “It is always a desire that thephilosophical work done as a doctoral thesis is inventive and innovative. This was possible by aninnovative processing of xenogeneic tissue for human usage. While the doctoral work won the bestthesis award from Indian National Science Academy (INSA) in 2008, the true victory is when it isavailable as a surgical patch for the world, made in India. It is a pleasure that Soma Guhathakurtha andSMBPL are taking this technology to offer SynkroScaff, a product conceived, researched, designed,developed and made in India, for the world.” Balasubramanian said the cost of imported material —between `30,000 and `35,000 — would be slashed by half using Indiamade implants.

CV Seshadri, MD, SMBPL said, “This sack is harvested and processed with biomaterial for ten days

followed by quality control parameters to ensure it is microbial free. In India, chemicals likeglutaraldehyde or formaldehyde are used, which are toxic and harmful, causing post complications inpatients; 12 of 13 have congenital heart defect. Most of them do not get proper treatment.”

Buffalo’s Heart Saves Human Lives in Form of Surgical Biomaterial Implant

In India, researchers at the Indian Institute of Technology, Madras have engineered a biomaterial implant from the sack of a buffalo’s heart that

can be used for patients with cardiovascular disease. The natural material, called SynkroScaff, helps regenerate and integrates well with the

human body. This is a big improvement compared to implants and surgical patches currently being used in India that are usually imported and

made with synthetic materials often including toxic chemicals like glutaraldehyde or formaldehyde that cause complications in patients. So far,

over 800 surgical patches have been made and used across three hospitals in India. Wondering what their success rate is so far in patients who

have had the implants? Amazingly, 100%. Another big benefit of the new surgical patch is that unlike the others, patients don’t have to have a

second operation to remove it later on.

Helena Kennedy

By Helena Kennedy - December 28, 2016

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Asia’s first ‘lifesaving’ implant developed by IITMnow in market28 Dec 2016, BioSpectrum Bureau , Biospecindia

Researchers at the Indian Institute of Technology, Madras (IITM) have developed Asia’s first ‘lifesaving’implant called SynkroScaff which is a tissue engineered bovine pericardial patch that can be used for criticalcardiovascular patients.

This technology, which has a global market has been put out into the market by a Chennaibased firmSynkroMax Biotech (SMBPL). This unique IITM pericardial patch (sack of buffalo’s heart) has inherentproperties of regeneration and integration in the body.

Unlike existing ones in India that are processed using synthetic material and toxic chemicals leading tocalcification, the product IITM came up with uses biomaterial. Currently, surgical patches are imported in India.

Soma Guhathakurta, IITM adjunct professor and director of SMBPL, said, “it had the potential to revolutionisethe field of surgical patches with products designed and made in India. This has twin advantages. One, India’sdependence on imports will be eliminated and two, patients don’t have to undergo a second procedure to removethe sack after usage. None of the synthetic, homologous (humanderived) and xenogeneic (compatible animalderived) patches have potential for growth and repair requiring reoperations.

Talking about the product, Soma Guhathakurta, IITM adjunct professor said, “The product has got versatile useto achieve anatomical correction of the heart and its blood vessels’ deformities and deficiencies. Its applicationsare immense in cardiovascular and other surgical practices. We obtained the licence for the product in May thisyear. So far, 800 patches have been manufactured and over 12 surgeons are using them across India."

Apollo Hospitals, Kauvery Hospital in Chennai and AIIMS in Delhi are using it. We have also enrolled forCentral Medical Services Society (CMSS) recognition of the product. The feedback from doctors and patients

has been encouraging, with a 100 per cent success rate.

The product is manufactured in a facility complying with drug applications and current good manufacturingpractice (cGMP) guidelines. Development of SynkroScaff using indigenous technology originally sprouted outof Guhathakurta’s doctoral research in IITM in 2004, under the guidance of Venkatesh Balasubramanian,professor, Department of Engineering Design at IITM.

Venkatesh Balasubramanian, who mentored Guhathakurta, said, “It is always a desire that the philosophicalwork done as a doctoral thesis is inventive and innovative. This was possible by an innovative processing ofxenogeneic tissue for human usage. While the doctoral work won the best thesis award from Indian NationalScience Academy (INSA) in 2008, the true victory is when it is available as a surgical patch for the world, madein India. It is a pleasure that Soma Guhathakurtha and SMBPL are taking this technology to offer SynkroScaff, aproduct conceived, researched, designed, developed and made in India, for the world.”

CV Seshadri, MD, SMBPL said, “This sack is harvested and processed with biomaterial for ten days followedby quality control parameters to ensure it is microbial free. In India, chemicals like glutaraldehyde orformaldehyde is used, which are toxic and harmful, causing post complications in patients; 12 of 13 havecongenital heart defect. Most of them do not get proper treatment.”

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SynkroMax Biotech sings MoU for life saving implant SynkroScaᚾ 0 , Latest News Medical Devices December 29, 2016 29 A+A-

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CHENNAI: Asia’s first life saving Implant , a Tissue Engineered Bovine PericardialPatch for critical cardiovascular patients is on its way to the market. SynkroScaff has developedby the researchers at the Indian Institute of Technology, Madras (IITM).

“SynkroScaff”

Chennaibased firm SynkroMax Biotech (SMBPL) has singed a memorandum of understandingfor selling this product solely in Asian global market.

The Technology Development Centre of SynkroMax is a stateoftheart facility set up forproviding Research and Development facilities to Research Scholars, Companies and Institutions,who would like to outsource the R & D activities. SynkroMax has the necessary expertise andqualified/ experienced personnel for Quality Assurance, Assay Development and Validation ofIndustrial and Speciality Enzymes.

Explaining the quality and features of the product, Soma Guhathakurta, IITM adjunct professorand director of SMBPL, said it had the potential to revolutionize the field of surgical patches withproducts designed and made in India. She further explained the advantages of the SynkroScaff :

1) India’s dependence on imports will be eliminated.

2) Patients won’t have to undergo a second procedure to remove the sack after usage.

3) SynkroScaff has inherent properties of regeneration and integration in the body.

CV Seshadri, MD, SMBPL said, “This sack is harvested and processed with biomaterial for ten days followed by quality control parameters to ensure it is microbialfree. In India, chemicals like glutaraldehyde or formaldehyde are used, which are toxic and harmful, causing post complications in patients; 12 of 13 have congenitalheart defect. Most of them do not get proper treatment.”

The development of SynkroScaff using indigenous technology originally sprouted out of Guhathakurta’s doctoral research in IITM in 2004, under the guidance ofVenkatesh Balasubramanian, professor, Department of Engineering Design it.

Soma Guhathakurta claims that the product has got versatile use to achieve anatomical correction of the heart and its blood vessels’ deformities and deficiencies.“Its applications are immense in cardiovascular and other surgical practices. We obtained the licence for the product in May this year. So far, 800 patches have beenmanufactured and over 12 surgeons are using them across India. Apollo Hospitals, Kauvery Hospital in Chennai and AIIMS in Delhi are using it. We have alsoenrolled for Central Medical Services Society (CMSS) recognition of the product. The feedback from doctors and patients has been encouraging, with a 100 per centsuccess rate. The product is manufactured in a facility complying with drug applications and current good manufacturing practice (cGMP) guidelines, she added”,reports Media

Venkatesh Balasubramanian, who mentored Guhathakurta, said, “It is always a desire that the philosophical work done as a doctoral thesis is inventive andinnovative. This was possible by an innovative processing of xenogeneic tissue for human usage. While the doctoral work won the best thesis award from IndianNational Science Academy (INSA) in 2008, the true victory is when it is available as a surgical patch for the world, made in India. It is a pleasure that SomaGuhathakurtha and SMBPL are taking this technology to offer SynkroScaff, a product conceived, researched, designed, developed and made in India, for the world.Balasubramanian said the cost of imported material between 30,000 and 35,000 would be slashed by half using Indiamade implants.”

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SOURCE: WITH INPUTS

TAGGED WITH AIIMS AIIMS Delhi Apollo Hospitals Central Medical Services Society IIT Madras Indian National Science Academy

by: savita thakur