Page 1 of 14

IFRA-IOFI LABELLING MANUAL 2014 FOR THE HAZARD CLASSIFICATION AND LABELLING OF FLAVOUR AND FRAGRANCE SUBSTANCES ACCORDING TO THE UN GHS, UN TDG and EU DSD. IMPORTANT DISCLAIMER: 1. The IFRA Labelling Manual has been prepared by the IFRA Secretariat and the IFRA GHS Task Force. The information contained in the manual represents the views of these groups, but does not constitute findings of safety or a judgment as to whether any product requires special handling, nor an industry standard, and is provided as only one source of information to be considered in developing warnings or labelling. IFRA does not warrant its accuracy or completeness and cannot be held liable for errors, inaccuracies, or omissions in this document. The information provided by IFRA is not legal advice regarding compliance in any jurisdiction and should not be considered or used as a substitute for legal advice. 2. The guidance provided by IFRA does not relieve users of this manual of their obligations to comply with applicable national, regional, or local laws and regulations. Failure to comply with applicable national, regional, or local laws can result in adverse consequences, including criminal or civil penalties as well as civil liability. Users of the manual should consult with competent legal counsel to determine whether they are in compliance with national, regional, or local laws. 3. Neither IFRA nor any individual members or officers can be held liable for any loss or damage suffered by any user of the manual as a result of following, relying on, or otherwise making use of the IFRA Labelling Manual. All users of this document at all times retains all responsibility for appropriately labelling their products. 4. With the publication of this edition of the Manual, all previous editions should be considered out of date, and should no longer be used. BY USING THIS LABELLING MANUAL, YOU WILL BE DEEMED TO HAVE UNDERSTOOD AND ACCEPTED THE CONDITIONS OF THIS DISCLAIMER. Important information in regards to the release of the Labelling Manual 2014 (in the following abbreviated as LM): During 2014 approx. 110 materials have been reviewed. The total number of substances in Att I in LM 2014 is now 1517. The number of Natural Complex Substances (NCSs) in Att IV has become 308. 147 substances have been deleted from the LM due to no, or very low volume of use (VoU <1kg), and as a consequence have no longer been reviewed, see Appendix III ‘Deleted substance entries from LM 2013’. Similarly, 39 NCSs were deleted, see Appendix IV. However, this does not mean that those substances can no longer be used, and they might be re-introduced into future versions of the LM, should their use volumes warrant this. In future versions of the LM, Att III ‘DSD classifications’ will be deleted as the EU DSD/DPD Directive will be repealed in June 2015. In preparation of this change, the EINECS and EC-Index numbers have been moved to Att I. Some chemically modified NCSs have been moved from Att IV to Att I. As a consequence, a separate column for hydrocarbon content was created.

Page 2 of 14

Another format change is an extra column for the flashpoint, which is used to classify materials. It is reminded that these are typical values and flammability classification should always be based on the actual values. M-factors and footnotes in Att I have been separated from the “Name” column and are mentioned separately now. A dedicated working group has updated the NCS entries in the RIFM data base. In the process ISO source coding was introduced to better identify the NCS characteristics of the relevant material. At the same time, compositions were reviewed and updated. These updated compositions have been the basis for calculation of the classification. Where test data have been used to supplement or modify the classification, a footnote is indicated in a separate column. As a result, both Att IV and V were completely reviewed. In November we were informed about a REACH update of some substances abundantly present in NCSs, namely alpha and beta-pinene (CAS 80-56-8, 127-91-3 and 18172-67-3). The update concerns an addition of environmental EH A1, EH C1 classification. As soon as the data have been evaluated, the LM and affected NCS-es will be updated accordingly in the next year. Quality improvement of the LM is an ongoing activity and we welcome any comment on content or lay-out; please send your observations/remarks to carregui@ifraorg.org. A. GENERAL CONSIDERATIONS The IFRA/IOFI GHS Task Force, with global representation, including Brazil, Europe, the United States and Japan, classifies fragrance and flavour materials following the criteria laid out in the UN GHS guidance document, which is currently the 5th revised edition (the so-called “Purple Book”, which can be downloaded at:http://www.unece.org/trans/danger/publi/ghs/ghs_rev05/05files_e.html) In addition, the group also assigns UN Transport classifications. The Task Force takes into account the physical/chemical, toxicological and eco-toxicological data that have been reviewed for these substances at the time of the publication of this Labelling Manual. Substances that are to be classified as hazardous as well as those which are not classifiable based on current knowledge, are included in the attached lists. Decisions on how to deal with issues in the area of hazard assessment are documented in a Modus Operandi (MO) justifying the contents of the work product of the group (Labelling Manual and Flavour or Fragrance Ingredient Data Sheets (FFIDSs)). This document serves as a means to ensure an identical approach within the Fragrance and Flavour Industry during the classification process and to serve as a reference of supplementary convention and expert interpretation for specific fragrance and flavour raw materials. The benefit of this activity is to provide a single global classification of all flavour and fragrance materials to avoid regional differences as the GHS standards are rolled out globally over time. Please note that the MO is continuously improved. B. USE OF THE IFRA/IOFI LABELLING MANUAL The information provided in this Labelling Manual is intended to provide guidance to companies aiming at achieving a consistent hazard classification and labelling for fragrance and flavour ingredients. It must be stressed that:

Any official regional classification of substances prevails over self-classification of the GHS Task Force, unless there is evidence for a more severe classification.

The Attachments to this Manual are not comprehensive and the absence of a substance or a specific classification should not be taken to imply that no classification and/or labelling are required.

In order to make the Attachments as comprehensive as possible, the GHS Task Force welcomes any proposal for additions or amendments on the basis of voluntarily sharing such knowledge within the Flavour and Fragrance Industry.

The listing of a substance in one of the Attachments does not mean an approval for use in fragrances or flavours. Actually, some of the substances may be subject to restrictions or even

Page 3 of 14

bans for specific applications, as stipulated in the IFRA Standards, EU Cosmetic Legislation, flavour regulations, etc.

The implementation of a new or an amended classification or labelling should be initiated after publication of a new version of the LM (see section C).

For some of the substances, individual limit concentrations have been officially assigned in Annex VI of the EU regulation (EC) No 1272/2008 (referred to further on as the CLP Regulation). They are mentioned in the Attachments and have to be followed instead of the general so-called ‘administrative limit concentrations’ when classifying a mixture according to the conventional method of the EU CLP-, or EU DPD-Regulation respectively.

Each supplier is reminded that they bear the final responsibility for the appropriate classification and labelling of the products they place on the market, based on the composition of their product.

a) Aspiration hazard (UN GHS: AH Cat1; EU DSD: Xn; R65) Some substances and mixtures pose a specific hazard upon ingestion since they can be aspirated into the lung and cause lung damage. The criteria for classification are purely of a physicochemical nature (hydrocarbons or mixtures containing >10% hydrocarbons with a kinematic viscosity and/or surface tension below a given value). Based on measured results for a number of NCSs with hydrocarbon contents between 10 and 90+ %, and on similar measurements of some flavour and fragrance compounds, the Task Force has come to the conclusion that in practice, substances and mixtures containing more than 10% of hydrocarbon(s) fall within the criteria for viscosity and/or surface tension, unless the material is a solid or reported to be a viscous liquid. In the absence of data for a specific NCS and based on the above, it is recommended: - to determine the hydrocarbon content of substances (supplier information, analysis) and mixtures (calculation) and to classify as AH Cat 1 and Xn; R65 respectively if more than 10% hydrocarbons are present; - non-classification should only be possible if viscosity measurement results [and/or surface tension measurements (EU DSD)] are available for a specific substance or mixture. b) Classification of NCSs NCSs (Essential oils and volatile solvent extracts) used in perfume compounds (mixtures) and flavours are known to have variable composition. This variability is well defined by ISO norms and /or by industry statistics. The bridging principle approach, as defined by GHS, CLP and EU DPD, must be utilised to assess the impact of this variability on the classification. If robust test data are available, a specific quality of a NCS must be classified on the basis of the result as indicated in GHS (cf. 1.3.2.3). This classification, however, is only applicable to the specific material and its composition tested and other NCSs where the chemical composition has been demonstrated to be equivalent. For other grades of NCSs, and for endpoints for which reliable test data are lacking, the UN GHS guidance document, as well as the EU DSD/DPD and CLP regulations, incorporate requirements whereby the hazard classification of complex substances shall be evaluated on the basis of levels of their known chemical constituents. Where knowledge about hazardous constituents exists, e.g. on substances with sensitizing, toxic, harmful, corrosive, environmentally hazardous properties, the classification and subsequent labelling of these NCSs should follow the additivity rules for mixtures (GHS) and conventional method (EU CLP/DPD) respectively. Guidance for the typical presence of hazardous constituents occurring in the NCSs is provided in Attachment V. These values are a result of the shared knowledge of the Industry at the time of the publication of this LM. Constituents with only an aspiration hazard assigned are not mentioned as these are accounted for in the total hydrocarbon content. The hazard classifications derived following the approaches indicated above, are located in Attachment IV of this Manual. It is worth noting that some uncertainty exists especially with regard to older test data, as to whether the quality of a NCS on which the tests were carried out, corresponds to today’s quality . Attachment V, footnote 3 a-d, covers cases where the classification was obtained by reliable test data for a particular endpoint, as opposed to calculation.

Page 4 of 14

c) Classification of Fragrance and Flavour compounds containing NCSs Flavour and Fragrance compounds are mixtures according to the UN GHS guidance document. In practice, test data on the flavour or fragrance compounds are often not available or collected. Therefore, the classification of these products should be based on the chemical composition and must include the contributions of hazardous substances present as constituents in the NCSs present in the formulation. Available robust test data on specific NCSs should take precedence over the classification based on the levels of their known chemical constituents. This implies that the hazardous substances present in a NCS should be known and this information has to be included in the Safety Data Sheet of that NCS (section 3: Composition/information on ingredients, according to the UN GHS guidance document). In case of absence of this information, Attachment V can be used. However, it should be realized that when a NCS is mentioned in an official regulation (e.g. Annex VI of the EU CLP regulation) this classification must be used and not the classification resulting from the constituents. d) Transport classification The assignment of UN numbers, packing group and hazard class is based on the criteria as laid down in the Recommendations on the Transport of Dangerous Goods Model regulations as published by the United Nations, 18th edition (so-called Orange Book ST/SG/AC.10/1/Rev.18). The assigned UN-number is a recommendation, which should be used to verify detailed differences between the various modes of transport, such as air, sea and land (land transport can be separated into road, rail and in-land water ways). Where needed, the EU hazard classification of the substance is supplemented with the ADR-rules, including the links to the EU CLP and DSD/DPD. Also, for transport, due account should be given to any national deviations from the rules applied here. The table of UN Transport classifications for chemically defined substances can be found in attachment II of the LM. C. IMPLEMENTATION AND OTHER INFORMATION The time for implementing new or modified classifications as indicated in attachments I to V, should not exceed a period of six months following the publication of the LM. Also regional requirements must be observed. Please note that any legal requirement would prevail (see disclaimer). The GHS Task Force adds the following clarification regarding compliance:

New or modified classifications apply to the substances defined by the indicated Chemical Abstracts Service Registry numbers (CAS numbers) regardless of whether alternative CAS numbers exist.

New additions to the lists are marked with “ + “

Corrections and modifications are indicated with “ x “

For those substances, for which classification and labelling was not considered necessary based on the data available to the GHS Task Force, and consequently termed ‘Not Classified’, be aware that classification might arise when considering the presence of classified constituents, as outlined above.

UN GHS Following the UN GHS guidance document, the GHS Task Force applies the criteria for all hazard classes and categories (except for some physico-chemical hazards not encountered in F&F ingredients, see Appendix 1) as mentioned in the so-called “Purple Book” aiming at harmonized UN GHS classifications of substances. The results comprise the indication of Flash Point and Acute Toxicity Estimate (ATE). Furthermore, an M-factor of 1 has to be considered for the Environmental Hazard categories A1/C1 unless otherwise indicated. The labelling elements (Pictogram, Signal Word, Hazard statements, Precautionary statements) that have to be used for a given hazard classification are spelled out in Annexes 1, 2 and 3 to the UN GHS. The table of UN GHS hazard classifications for chemically defined substances can be found in attachment I of the LM.

Page 5 of 14

[are we confident that people will understand this ‘Intermezzo’? and is this emphasis really justified?] EU DSD/DPD Classifications: The classification and labelling of single substances in the EU has to follow the EU CLP Regulation. Only for mixtures, like flavour and fragrance compounds, the rules of the Dangerous Preparations Directive 1999/45/EC (EU DPD) can still be applied until 1

st June 2015. In order to allow compounders

to still follow the DPD up until then, the table of EU DSD hazard classifications for chemically defined substances are given in attachment III of the LM Note that Annex I to the DSD has been repealed and its adaptations to technical progress have been transferred to the CLP Regulation Annex VI. Several substances of interest to the fragrance and flavour industry with their official classifications are mentioned in Annex VI to the CLP Regulation. They are included in the respective attachments to this Labelling Manual with their Annex number next to their CAS and EU number. EU CLP: The difference in classification between UN-GHS and EU CLP is caused by the difference of implementation of the GHS building blocks.In Appendix II to this letter the differences in building blocks between the two classification schemes are given. For the blue coloured fields the schemes are identical, the yellow colour indicates a difference. To derive the respective classification for the EU CLP from the UN-GHS classification, one has to take out the building blocks that are not applicable in the EU from the UN-GHS classification. For example, a substance with ATO 5(3700), FL 4, SCI 3, will become “Not classified” under EU CLP, as the building blocks for Acute Toxicity Category 5, Flammability category 4 and Skin Irritation category 3 have not been implemented under the EU CLP Regulation. NCSs: Classifications provided in this annex are orientative based on available data for an average quality with a representative constituent information. They do not represent classifications for all qualities of an NCS as these may vary substantially. Therefore IFRA/IOFI cannot guarantee the accuracy of this information that is provided in good faith only to help companies identify possible classification considerations for their materials. It is the responsibility of NCS suppliers and/or manufacturers to ensure their NCSs are appropriately classified based on test data or on constituent information for their specific supplied material. The table of UN TDG, EU DSD and UN GHS hazard classifications/hazard statements for NCS can be found in attachment IV of the LM. In the case of absence of information about actual levels of hazardous substances present in NCSs, this list should be taken into account for the hazard classification of NCSs and for their contributions to the hazard classification of flavour and fragrance compounds. The table on the potential presence of hazardous constituents in NCSs, containing percentage information, UN GHS and EU DSD classification can be found in attachment V of the LM.

Intermezzo: As stated, the GHSTask Force evaluates all classes and categories of UN-GHS. To fill the differential with the EU CLP regulation; where an Annex VI classification exists, the classification can be extended with the Environmental Acute categories A2 and A3. In addition, as these CLP classifications are “minimum” classifications, they might also have been supplemented with REACH classifications where more severe categories are assigned.

Page 6 of 14

Appendix I Overview of GHS hazard classes considered and the abbreviations used. Appendix II Overview of UN-GHS and EU-CLP building blocks Appendix III Deleted substance entries from LM 2013 Appendix IV: Deleted NCS entries from LM 2013

Page 7 of 14

Appendix I GHS Hazard classes and related abbreviations: The table below reflects the 4 physical, 11 health and 1 environmental hazard classes as well as abbreviations that have been used.

GHS Hazard Class GHS Class abbreviation

GHS Hazard Categories

Flammable gas FG

Pressurised gas PG

Flammable liquid FL 1,2,3,4

Flammable solid FS 1,2

Acute toxicity, oral ATO 1,2,3,4,5

Acute toxicity, dermal ATD 1,2,3,4,5

Acute toxicity, inhalation ATI 1,2,3,4,5

Skin corrosion/irritation SCI 1A,1B,1C,2,3

Serious eye damage/eye irritation EDI 1,2A,2B

Respiratory sensitization RS 1

Skin sensitization SS 1, 1A,1B

Germ cell mutagenicity MUT 1A,1B,2

Carcinogenicity CAR 1A,1B,2

Reproductive Toxicity REP 1A,1B,2

Specific Target Organ toxicity – Single exposure

STO-SE 1, 2

Specific Target Organ toxicity – Single exposure

STO-SE (NE) 3 (Transient target organ effects: narcotic effects)

Specific Target Organ toxicity – Single exposure

STO-SE (RI) 3 (Transient target organ effects: respiratory tract irritation)

Specific Target Organ toxicity – Repeated exposure

STO-RE 1, 2

Aspiration hazard AH 1, 2

Hazardous to aquatic environment EH A1,A2,A3,C1,C2,C3,C4

Repeated exposure may cause skin dryness or cracking.

EUH 66

Corrosive to the respiratory tract. EUH 71

Page 8 of 14

Appendix II

Difference of building blocks between UN-GHS and EU-CLP:

GHS Hazard Class GHS Class

Abbreviation GHS Hazard Categories EU

Flammable liquid FL 1,2,3,4 1,2,3

Flammable solid FS 1,2 1,2

Acute toxicity, oral ATO 1,2,3,4,5 1,2,3,4

Acute toxicity, dermal ATD 1,2,3,4,5 1,2,3,4

Acute toxicity, inhalation ATI 1,2,3,4,5 1,2,3,4

Skin corrosion/irritation SCI 1A,1B,1C,2,3 1A,1B,1C,2

Serious eye damage/eye irritation EDI 1,2A,2B 1,2

Respiratory sensitization RS 1(A,B) 1(A,B)

Skin sensitization SS 1(A,B) 1(A,B)

Germ cell mutagenicity MUT 1A,1B,2 1A,1B,2

Carcinogenicty CAR 1A,1B,2 1A,1B,2

Reproductive Toxicity REP 1A,1B,2 1A,1B,2

Reprotox: Effects on or via lactation

yes yes

Specific Target Organ systemic toxicity - Single exposure

STO-SE 1, 2 1, 2

Specific Target Organ systemic toxicity - Single exposure

STO-SE 3 (Transient target organ effects: narcotic effects) 3-NE

Specific Target Organ systemic toxicity - Single exposure

STO-SE 3 (Transient target organ effects: respiratory tract irritation) 3-RI

Specific Target Organ systemic toxicity - Repeated exposure

STO-RE 1, 2 1, 2

Aspiration hazard AH 1, 2 1

Acute aquatic toxicity EH A1,A2,A3 A1

Chronic aquatic toxicity EH C1,C2,C3,C4 C1,C2,C3,C4

Legend: blue=identical; yellow=different.

Page 9 of 14

Appendix III Deleted substance entries from LM 2013

CAS Number

REACH Name

60-35-5 Acetamide

69-72-7 Yes 2-Hydroxybenzoic acid

74-89-5 Yes Methylamine

75-31-0 Yes Isopropylamine

75-85-4 Yes 2-Methyl-2-butanol

78-79-5 Yes Isoprene

80-62-6 Yes Methyl methacrylate

90-15-3 1-Naphthol

91-22-5 Yes Quinoline

91-60-1 2-Naphthalenthiol

95-92-1 Yes Diethyl oxalate

96-22-0 Yes Diethyl ketone

96-33-3 Yes Methyl acrylate

97-63-2 Yes Ethyl methacrylate

97-95-0 2-Ethyl-1-butanol

98-82-8 Yes Cumene

98-83-9 Yes alpha-Methylstyrene

100-66-3 Yes Anisole

103-25-3 Methyl 3-phenylpropionate

104-64-3 3-Phenylpropyl formate

105-46-4 2-Butyl acetate

106-63-8 Yes Isobutyl acrylate

107-02-8 Yes 2-Propenal

107-18-6 Yes Allyl alcohol

107-31-3 Yes Methyl formate

108-48-5 2,6-Dimethylpyridine

108-59-8 Yes Dimethyl malonate

108-89-4 4-Methylpyridine

108-99-6 Yes 3-Methylpyridine

109-06-8 2-Methylpyridine

109-66-0 Yes n-Pentane

109-89-7 Yes Diethylamine

110-01-0 Yes Tetrahydrothiophene

110-12-3 Yes 5-Methyl-2-Hexanone

110-16-7 Yes Maleic acid

111-28-4 2,4-Hexadien-1-ol

111-84-2 Yes Nonane

119-65-3 Yes Isoquinoline

120-58-1 Isosafrole

124-40-3 Yes Dimethylamine

135-19-3 Yes 2-Naphthol

Page 10 of 14

141-32-2 Yes Butyl acrylate

141-79-7 Yes 4-Methyl-3-penten-2-one

142-96-1 Yes Butyl ether

150-76-5 Yes 4-Methoxyphenol

498-16-8 2-Isopropenyl-5-methyl-4-hexen-1-ol

540-63-6 1,2-Ethanedithiol

540-88-5 Yes tert-Butyl acetate

547-64-8 Methyl lactate

563-80-4 Yes 3-Methyl-2-butanone

565-80-0 2,4-Dimethylpentan-3-one

583-59-5 Yes 2-Methylcyclohexanol

583-60-8 2-Methylcyclohexanone

589-40-2 2-Butyl formate

591-78-6 Methyl n-butyl ketone

625-84-3 2,5-Dimethylpyrrole

644-35-9 o-Propylphenol

698-27-1 2-Hydroxy-4-methylbenzaldehyde

700-82-3 Hexahydrocoumarin

763-32-6 Yes 3-Methylbut-3-en-1-ol

814-67-5 1,2-Propanedithiol

943-88-4 4-(p-Methoxyphenyl)-3-butene-2-one

1009-62-7 2,2-Dimethyl-3-phenylpropionaldehyde

1120-21-4 Yes Undecane

1733-25-1 Isopropyl tiglate

1797-74-6 Allyl phenylacetate

1963-36-6 p-Methoxycinnamaldehyde

1900-69-2 trans-4-tert-Butylcyclohexyl acetate

2155-30-8 dl-Methyl lactate

2294-76-0 2-Pentylpyridine

2438-20-2 2-Methylbutyl propionate

3572-06-3 4-(p-Acetoxyphenyl)-2-butanone

3613-33-0 7-Ethoxy-3,7-dimethyloctanal

4433-36-7 3,4,5,6-Tetrahydropseudoionone

4435-53-4 Yes 3-Methoxybutyl acetate

4437-22-3 Difurfuryl ether

5166-53-0 5-Methyl-3-hexen-2-one

5406-12-2 p-Methylhydrocinnamic aldehyde

5406-86-0 2-(4-tert-Butyl phenyl) ethanol

5459-37-0 Heptyl methacrylate

6090-15-9 2,6-Dimethyl-2-hepten-6-ol

6876-13-7 cis-Pinane

6911-51-9 2-Thienyl disulfide

7149-24-8 Cyclamen aldehyde diethyl acetal

7217-59-6 2-Methoxythiophenol

Page 11 of 14

7443-52-9 trans-2-Methylcyclohexanol

7443-70-1 cis-2-Methylcyclohexanol

7493-78-9 alpha-Amylcinnamyl acetate

908030-97-5 Pyroligneous acid, extract

10024-64-3 Linalyl octanoate

13393-93-6 Yes Hydroabietyl alcohol

15768-07-7 Methyl 2-benzylidene-3-oxobutyrate

17092-92-1 Dihydroactinidiolide

17392-83-5 Yes Methyl (R)-lactate

17626-75-4 2-Propylthiazole

18318-83-7 trans-2-Hexenal dimethyl acetal

18383-49-8 Carvone-5,6-oxide

18829-55-5 trans-2-Heptenal

19673-87-1 5-Methylthieno[2,3-d]pyrimidine

20030-30-2 Yes 2,5,6-Trimethylcyclohex-2-en-1-one

23747-43-5 Ethyl 2-(methyldithio)propionate

24089-00-7 3-Methyl-1-octen-3-ol

24237-02-3 2-Butyltetrahydro-6-methyl-4-methylene-2H-pyrane

24342-03-8 iso-Butyl but-3-enoate

26486-21-5 cis and trans-2,5-Dimethyltetrahydrofuran-3-thiol

27871-49-4 Yes Methyl (S)-lactate

28588-76-3 Bis(2-methyl-3-furyl) tetrasulfide

29171-20-8 Yes Dehydrolinalool

29886-96-2 Cyclamen aldehyde dimethyl acetal

32539-83-6 Yes 2H-Cyclododeca[b]pyran, 3,4,5,6,7,8,9,10,11,12,13,14-dodecahydro-

33204-74-9 cis-Carvone oxide

33673-71-1 1-(2,4,4-Trimethyl-2-cyclohexen-1-yl)-2-buten-1-one

35073-27-9 2-Methylbutyl formate

37172-05-7 1-Acetoxy-1-ethynyl-2-sec-butylcyclohexane

37443-42-8 Methyl tetrahydro-2-furancarboxylate

38205-60-6 2,4-Dimethyl-5-acetylthiazole

39189-74-7 2-Heptylidenecyclopentan-1-one

40649-36-3 Yes 4-Propylcyclohexanone

43040-01-3 3-Methyl-1,2,4-trithiane

54814-64-1 5-Hydroxy-2-decenoic acid delta-lactone

55764-28-8 2,5-Dimethyl-3-thioisovalerylfuran

55764-34-6 2,5Dimethyl-3-thiobenzoylfuran

58102-02-6 2-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-butenal

58437-69-7 Patchenyl acetate

61197-09-9 Propyl 2-methyl-3-furyl disulfide

61203-83-6 4-Pentyl cyclohexanone

61295-41-8 3-((2-Methyl-3-furyl)thio)-4-heptanone

61597-96-4 2-Methylpropyl (R)-lactate

61792-12-9 Cinnamyl tiglate

Page 12 of 14

61947-19-1 2,5-Dimethyl-2,3-dihydro-1,4-dithiin

67770-79-0 5-Butyl-5-ethyltetrahydro-2H-pyran-2-one

68165-40-2 1,3,5-Triisobutyl-2,4,6-trioxane

68480-17-1 Dihydromethyl-alpha-ionone

70851-60-4 Geranyl dihydrolinalool

72084-99-2 Cyclamen aldehyde propylene glycol acetal

72531-53-4 2-Methylpropyl 2-hydroxy-2-methylbut-3-enoate

72812-40-9 1,2,4 (or 1,3,5)-Trimethyl-3-cyclohexene-1-methanol

72845-85-3 Cyclamen aldehyde ethylene glycol acetal

84145-37-9 2(or 3)-Methylbutyl acetate

87172-89-2 exo-1-Methyl-4-(1-methylethyl)-7-oxabicyclo[2.2.1]heptan-2-ol

88805-65-6 Ethyl 3-hydroxy-5-oxo-3-cyclohexene-1-carboxylate

94291-50-6 1-Methoxyhexane-3-thiol

94386-48-8 Cinnamic aldehyde-methyl anthranilate (Schiff base)

97101-46-7 Methyl 3-(acetylthio)-2-methyl propanoate

114119-97-0 2,5,7,7-Tetramethyloctanal

115724-27-1 Cyclohexanol, 2-(1,1-dimethylethyl)-4-methyl-, acetate

143468-96-6 Ethyl 2-carboxy-3-(2-thienyl)propionate

Page 13 of 14

Appendix IV Deleted NCS entries from LM 2013

EU Index no

EC number EINECS CAS

No. Alternative

CAS No. Name

305-227-1 94350-09-1 n.a. Agarwood

294-681-3 91745-13-0 8001-99-8 Ajowan oil

283-903-4 84775-74-6 n.a. Artemesia annua extract

283-476-4 84649-96-7 8022-81-9 Boldo oil

289-682-0 89997-47-7 8006-99-3 Chenopodium oil (worm seed)

650-015-00-7

(ATP 21) 232-475-7 8050-09-7 8052-10-7 Colophony

290-278-1 90106-55-1 8023-88-9 Costus oil

876068-15-4

Curry leaf oil, Malaysian

305-084-4 94334-04-0 71990-26-6 Eriocephalus oil

289-868-1 90028-74-3 68916-52-9 Fig leaf absolute

283-891-0 84775-62-2 84775-62-2 Horseradish oil

289-970-6 90046-03-0 68916-94-9 Juniperus phoenicea oil (Savin oil)

289-970-6 90046-03-0 8024-00-8 Savin oil (Juniperus phoenicea)

289-996-8 90063-38-0 n.a. Lavender stoechas oil

283-496-3 84650-15-7 84650-15-7 Leek oil

296-611-7 92874-96-9 8006-86-8 Linaloe wood oil

285-357-2 85085-26-3 85085-26-3 Massoia oil

282-007-0 84082-61-1 8014-71-9 Melissa oil (Lemon balm)

290-076-3 90064-15-6 8007-40-7 Mustard oils

310-217-5 132940-73-9 8014-68-4 Niaouli oil

285-383-4 85085-57-0 68917-09-9 Ocotea cymbarum oil (carc.cat 2), (muta.cat 3)

283-403-6 84625-29-6 84625-29-6 Paprika oleoresin

290-129-0 90082-39-6 68917-22-6 Parsnip oil

296-189-4 92347-03-0 8002-47-7 Pemou oil

296-036-1 92209-04-6 n.a. Pinus cembra (Swiss stone)

284-647-6 84961-58-0 Santolina oil

290-280-2 90106-57-3 90106-57-3 Savoury oil (Satureja montana, winter variety)

289-592-1 89957-73-3 8016-69-1 Snakeroot oil

304-864-2 94280-16-7 94280-16-7 Vanilla pompona, ext.

296-192-0 92347-05-2 68991-32-2 Zdravetz oil

272-046-1 68650-44-2 72869-69-3 Apricot kernel oil

232-419-1 8021-39-4 8021-39-4 Beechwood creosote

294-926-4 91771-36-7 8053-33-6 Boronia oil

305-055-7 94333-75-2 8023-94-7 Hyacinth absolute

305-095-5 94334-14-2 68916-95-0 Karo karounde abs.

Page 14 of 14

303-413-7 94167-14-3 94167-14-3 Vanilla tahitensis

277-143-2 72968-50-4 Orange leaf concrete

277-143-2 72968-50-4 Orange leaf water absolute

284-023-3 84776-98-7 8007-46-3 Thyme oil wild