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IntraLase TechnologyInnovative Technology for Truly Custom-Designed LASIK Flaps
The unparalleled uniformity and precision, biomechanical stability, and unsurpassed safety profile delivered by IntraLase Technology are key components of the iLASIK Technology Suite.
Biomechanical Stability• Strongerflapsthrough faster wound healing1
• Increasedadhesionpostoperatively1
Enhanced Safety• Flapcreationsafetyadvantages
• Postoperativesafetyadvantages
• Over3.5millionproceduresandcounting
Unparalleled Uniformity and Precision• Unparalleled control over flap parameters such as: diameter • depth • edge angle • centration
• Significantlysmootherstromalbeds
Advanced Corneal Options• IntraLase Enabled Keratoplasty (IEK)
• Intrastromalringimplantation
IntraLase Technology: TwoInnovativeLaserPlatforms
AMOofferstwoinnovativelaserplatforms.Bothlasersystems embody IntraLase Technology, an essential element of the iLASIK Solution.
• IntraLase FS Laser System — Gives surgeons unparalleled control for safer, precision-designed treatments
• iFS Femtosecond Laser System — Has all the features of the IntraLase FS System, plus increased speed and enhanced flap-customization capabilities. For example, surgeons can make an inverted bevel-in side cut and select an elliptical flap option
Faster Visual RecoveryIntraLase Technology Showed Faster Visual Recovery2
Atalltimepointsmeasured,thepercentageofeyesthatachievedapostoperativeUCVAof20/20orbetter was significantly higher in the femtosecond group.
Aretrospectiveanalysisof1,000eyestreated with the IntraLase FS Laser and 1,000eyestreatedwithamechanicalmicrokeratome(N=2,000).
90%
95%
100%
85%
80%
75%1 Day
83%
89%
FemtosecondMicrokeratome
86%
93%
93%
96%
93%
96%
1 Week 1 Month 3 Month
Follow-up
Faster Visual Recovery
Perc
enta
ge o
f eye
s th
at a
chie
ved
unco
rrec
ted
visu
al a
cuity
of 2
0/20
or
bette
r
The IntraLase FS and iFS Laser Systems are ophthalmic surgical lasers indicated for use in patients undergoing surgery or treatment requiring the initial lamellar resection of the cornea. Contraindications may include corneal edema, glaucoma, and keratoconus. Risks and complications may include corneal pain, flap tearing, and epithelial ingrowth. Patients are requested to consult with their eye care professional for a complete listing of contraindications and risks. U.S. Federal law restricts this device to sale, distribution, and use by or on the order of a physician or other licensed eye care practitioner.
The unparalleled uniformity and precision, biomechanical stability, and unsurpassed safety profile delivered by IntraLase Technology are key components of the iLASIK Technology Suite.
Biomechanical Stability• Strongerflapsthrough faster wound healing1
• Increasedadhesionpostoperatively1
Enhanced Safety• Flapcreationsafetyadvantages
• Postoperativesafetyadvantages
• Over3.5millionproceduresandcounting
Unparalleled Uniformity and Precision• Unparalleled control over flap parameters such as: diameter • depth • edge angle • centration
• Significantlysmootherstromalbeds
Advanced Corneal Options• IntraLase Enabled Keratoplasty (IEK)
• Intrastromalringimplantation
IntraLase Technology: TwoInnovativeLaserPlatforms
AMOofferstwoinnovativelaserplatforms.Bothlasersystems embody IntraLase Technology, an essential element of the iLASIK Solution.
• IntraLase FS Laser System — Gives surgeons unparalleled control for safer, precision-designed treatments
• iFS Femtosecond Laser System — Has all the features of the IntraLase FS System, plus increased speed and enhanced flap-customization capabilities. For example, surgeons can make an inverted bevel-in side cut and select an elliptical flap option
Faster Visual RecoveryIntraLase Technology Showed Faster Visual Recovery2
Atalltimepointsmeasured,thepercentageofeyesthatachievedapostoperativeUCVAof20/20orbetter was significantly higher in the femtosecond group.
Aretrospectiveanalysisof1,000eyestreated with the IntraLase FS Laser and 1,000eyestreatedwithamechanicalmicrokeratome(N=2,000).
90%
95%
100%
85%
80%
75%1 Day
83%
89%
FemtosecondMicrokeratome
86%
93%
93%
96%
93%
96%
1 Week 1 Month 3 Month
Follow-up
Faster Visual Recovery
Perc
enta
ge o
f eye
s th
at a
chie
ved
unco
rrec
ted
visu
al a
cuity
of 2
0/20
or
bette
r
The IntraLase FS and iFS Laser Systems are ophthalmic surgical lasers indicated for use in patients undergoing surgery or treatment requiring the initial lamellar resection of the cornea. Contraindications may include corneal edema, glaucoma, and keratoconus. Risks and complications may include corneal pain, flap tearing, and epithelial ingrowth. Patients are requested to consult with their eye care professional for a complete listing of contraindications and risks. U.S. Federal law restricts this device to sale, distribution, and use by or on the order of a physician or other licensed eye care practitioner.
BiomechanicalStability
Average SBK Flap Thickness
CourtesyofJasonStahl,MD,DurrieVision,OverlandPark,KS,USA.
120
140
160
100
80
60
40
20
0-4 -1 +1 +4 -4 -1 +1 +4 -4 -1 +1 +4 -4 -1 +1 +4
OverallAverage
SD + 5 µm
Mic
rons
Millimeters
113
11311
0
110
113
11311
0
111
114
11311
1
111
114
113
11211
0
109
N=25
CourtesyofJasonStahl,MD,DurrieVision,OverlandPark,KS,USA.
EnhancedSafetywithUnparalleledUniformityandPrecision
Flap Creation Safety Advantages3-5
Reduces or eliminates several complications including:
• Buttonholeorfreeflaps
• Irregularflaps
• Microperforations
• Decenteredflaps
• Epithelialdefects
Postoperative Safety Advantages3-5
• Lessectasia
• Reducedhigher-orderaberrations(HOAs)
• Improvedcontrastsensitivityandlower enhancement rates
Unparalleled Uniformity and Precision Give You the Ability to Precision-Design Your Patients’ Intracorneal Architecture
The unique computer-controlled laser system enables surgeons to create thin, planar flaps with a uniform mean thickness of 112±5µmandanaveragestandarddeviationofaslittleas4µmwithineachflap,6 maximizing residual bed and potentially producing a more stable post-LASIK cornea.
“All-laser” IntraLase Technology offers numerous safety advantages over microkeratome technology both during flap creation and postoperatively.
In New Zealand White rabbit eyes, three groups of flaps were created with either theAMADEUS™ microkeratome, iFS Laser70°sidecutangle,oriFS Laser 140°sidecutangle.At3months,aforce gauge was attached to a curved lens and pulled perpendicularly until the flap dehisced and peak force could be measured. Note the IntraLase FS Laser hasasidecutangleupto90°.
700
600
500
400
300
200
100
0Microkeratome
AMADEUSIntraLase iFS Laser
70˚ Side Cut
Peak Force Measured
IntraLase iFS Laser140˚ Side Cut
2x stronger than AMADEUSMicrokeratome
3x stronger than AMADEUSMicrokeratome
3-Month Comparative Measurement of Flap Tensile Strengths1
Gram
s of
forc
e re
quire
d to
lift
“These studies were statistically significant and certainly suggest that the inverted bevel design of the IntraLase flap is far more stable than mechanically created flaps. The ability to precisely create truly customized flaps for every patient further validates the iLASIKProcedure.”
— Prof. Dr. Michael C. Knorz
FreeVis LASIK Zentrum, Universitätsklinikum Mannheim, Germany
BiomechanicalStability
Average SBK Flap Thickness
CourtesyofJasonStahl,MD,DurrieVision,OverlandPark,KS,USA.
120
140
160
100
80
60
40
20
0-4 -1 +1 +4 -4 -1 +1 +4 -4 -1 +1 +4 -4 -1 +1 +4
OverallAverage
SD + 5 µm
Mic
rons
Millimeters
113
11311
0
110
113
11311
0
111
114
11311
1
111
114
113
11211
0
109
N=25
CourtesyofJasonStahl,MD,DurrieVision,OverlandPark,KS,USA.
EnhancedSafetywithUnparalleledUniformityandPrecision
Flap Creation Safety Advantages3-5
Reduces or eliminates several complications including:
• Buttonholeorfreeflaps
• Irregularflaps
• Microperforations
• Decenteredflaps
• Epithelialdefects
Postoperative Safety Advantages3-5
• Lessectasia
• Reducedhigher-orderaberrations(HOAs)
• Improvedcontrastsensitivityandlower enhancement rates
Unparalleled Uniformity and Precision Give You the Ability to Precision-Design Your Patients’ Intracorneal Architecture
The unique computer-controlled laser system enables surgeons to create thin, planar flaps with a uniform mean thickness of 112±5µmandanaveragestandarddeviationofaslittleas4µmwithineachflap,6 maximizing residual bed and potentially producing a more stable post-LASIK cornea.
“All-laser” IntraLase Technology offers numerous safety advantages over microkeratome technology both during flap creation and postoperatively.
In New Zealand White rabbit eyes, three groups of flaps were created with either theAMADEUS™ microkeratome, iFS Laser70°sidecutangle,oriFS Laser 140°sidecutangle.At3months,aforce gauge was attached to a curved lens and pulled perpendicularly until the flap dehisced and peak force could be measured. Note the IntraLase FS Laser hasasidecutangleupto90°.
700
600
500
400
300
200
100
0Microkeratome
AMADEUSIntraLase iFS Laser
70˚ Side Cut
Peak Force Measured
IntraLase iFS Laser140˚ Side Cut
2x stronger than AMADEUSMicrokeratome
3x stronger than AMADEUSMicrokeratome
3-Month Comparative Measurement of Flap Tensile Strengths1
Gram
s of
forc
e re
quire
d to
lift
“These studies were statistically significant and certainly suggest that the inverted bevel design of the IntraLase flap is far more stable than mechanically created flaps. The ability to precisely create truly customized flaps for every patient further validates the iLASIKProcedure.”
— Prof. Dr. Michael C. Knorz
FreeVis LASIK Zentrum, Universitätsklinikum Mannheim, Germany
The iFS Femtosecond Laser System has all the features of the IntraLase FS System, plus increased speed and enhanced flap-customization capabilities that include:
• Invertedbevel-insidecutupto150°
• Ellipticalflapoption
• Higherrepetitionrateandfasterproceduretime— enhance patient comfort and confidence
• Tighterspotseparation—providessmootherstromal beds and a virtually effortless flap lift
• Lowerenergyperpulse—mayreducetissueresponse and inflammation
• High-resolutionvideomicroscope—formaximum surgeon comfort
Elliptical Flap Enhances Surgical Options
• Distributesforcessymmetricallytotheellipticalcornea
• Preventsresectionofthevitalperipheralcornealfibers that contribute greatly to the biomechanical strength of the cornea
• Movesthehingeperipherallytomaximizestromalbed exposure for full delivery of excimer ablation
• Allowsuseofawiderhingeangletocreate flap stability
Inverted Bevel-In Side Cut
Invertedbevel-insidecut,customizableto150°,promotes flap replacement, positioning and adhesion for optimal biomechanical stability of the post-LASIK cornea.
New Capabilities from the Latest Femtosecond Laser
Elliptical Flap Round Flap
IntraLase Technology results in significantly higher-quality stromal beds than are possible with the FEMTOLDV™.
• StromalbedroughnesswiththeiFSLaserwas39.55nm• StromalbedroughnesswiththeIntraLase FSLaserwas41.20nm• StromalbedroughnesswiththeZiemerFEMTOLDVLaserwas42.87nm
Images of the IntraLase FSLaserandZiemerFEMTOLDVLaserareprovidedbyDr.DanielS.Durrie.
IntraLase FS Laser (9x) IntraLase FS Laser (300x)
iFS Laser (9x) iFS Laser (300x)
Ziemer FEMTO LDV Laser (9x)
Ziemer FEMTO LDV Laser (300x)
Significantly Smoother StromalBeds
150°
InvertedSideCutOptionto150°
The iFS Femtosecond Laser System has all the features of the IntraLase FS System, plus increased speed and enhanced flap-customization capabilities that include:
• Invertedbevel-insidecutupto150°
• Ellipticalflapoption
• Higherrepetitionrateandfasterproceduretime— enhance patient comfort and confidence
• Tighterspotseparation—providessmootherstromal beds and a virtually effortless flap lift
• Lowerenergyperpulse—mayreducetissueresponse and inflammation
• High-resolutionvideomicroscope—formaximum surgeon comfort
Elliptical Flap Enhances Surgical Options
• Distributesforcessymmetricallytotheellipticalcornea
• Preventsresectionofthevitalperipheralcornealfibers that contribute greatly to the biomechanical strength of the cornea
• Movesthehingeperipherallytomaximizestromalbed exposure for full delivery of excimer ablation
• Allowsuseofawiderhingeangletocreate flap stability
Inverted Bevel-In Side Cut
Invertedbevel-insidecut,customizableto150°,promotes flap replacement, positioning and adhesion for optimal biomechanical stability of the post-LASIK cornea.
New Capabilities from the Latest Femtosecond Laser
Elliptical Flap Round Flap
IntraLase Technology results in significantly higher-quality stromal beds than are possible with the FEMTOLDV™.
• StromalbedroughnesswiththeiFSLaserwas39.55nm• StromalbedroughnesswiththeIntraLase FSLaserwas41.20nm• StromalbedroughnesswiththeZiemerFEMTOLDVLaserwas42.87nm
Images of the IntraLase FSLaserandZiemerFEMTOLDVLaserareprovidedbyDr.DanielS.Durrie.
IntraLase FS Laser (9x) IntraLase FS Laser (300x)
iFS Laser (9x) iFS Laser (300x)
Ziemer FEMTO LDV Laser (9x)
Ziemer FEMTO LDV Laser (300x)
Significantly Smoother StromalBeds
150°
InvertedSideCutOptionto150°
©2009AbbottMedicalOpticsInc.Abbotttrademarksandproductsin-licensedbyAbbottareshowninboldanditalics. AMADEUSisatrademarkofSurgicalInstrumentSystems.FEMTOLDVisatrademarkofZiemerGroup.2009.07.29-IL1180
*20/16resultsdeliveredwithexcimerlaser;clinicalstudiessenttotheFDAviaP930016supplement021.
The iLASIK SolutionAdvanced Technology that Delivers Personal Best Vision
The iLASIKSolution,availableexclusivelyfromAMO,isthecombinationofIntraLase and Advanced CustomVue Technologies. This unique blend of technologies sets a new standard for laser vision correction.
• 20/16 or Better – The exclusive combination of IntraLase and Advanced CustomVue Technologies provides a truly customizedtreatment,capableofproducing20/16orbettervision*
• Good Enough for NASA and Your Patients –NASAastronautsandU.S.fighterpilotscanhavelaservisioncorrectionsurgerytodaybecauseof the exclusive, validated safety and precision performance of iLASIK Technologies
• Leading Innovation –Withover20yearsofinnovationandmorethan10million procedures worldwide, iLASIK Technologies are the true industry leaders
• Physician Confidence – The iLASIKPlatform,alongwithunmatchedserviceandsupport, gives surgeons the confidence to consistently deliver the best possible outcomes for the broadest range of patients
References1. KnorzMC,VossmerbaeumerU.ComparisonofflapadhesionstrengthusingtheAmadeusmicrokeratomeandtheIntraLase iFS femtosecond laser in rabbits. J Refract Surg.2008;24(9):875-878.2. Tanna M, Schallhorn SC, Hettinger KA. Femtosecond laser versus mechanical microkeratome: A retrospective comparison of visual outcomesat3months.J Refract Surg.2009;25(suppl7):S668-S671.3. BinderPS.OnethousandconsecutiveIntraLase laser in situ keratomileusis flaps. J Cataract Refract Surg.2006;32(6):962-969.4. StonecipherK,IgnacioTS,StonecipherM.Advancesinrefractivesurgery:microkeratomeandfemtosecondlaserflapcreation in relation to safety, efficacy, predictability, and biomechanical stability. Curr Opin Ophthalmol.2006;17(4):368-372.5. KezirianGM,StonecipherKG.ComparisonoftheIntraLase femtosecond laser and mechanical keratomes for laser in situ keratomileusis. J Cataract Refract Surg.2004;30(4):804-811.6. StahlJE,DurrieDS,SchwendemanFJ,etal.AnteriorsegmentOCTanalysisofthinIntraLase femtosecond flaps. J Refract Surg.
2007;23(6):555-558.
The IntraLase FS and iFS Laser Systems are ophthalmic surgical lasers indicated for use in patients undergoing surgery or treatment requiring the initial lamellar resection of the cornea. Contraindications may include corneal edema, glaucoma, and keratoconus. Risks and complications may include corneal pain, flap tearing, and epithelial ingrowth. Patients are requested to consult with their eye care professional for a complete listing of contraindications and risks. U.S. Federal law restricts this device to sale, distribution, and use by or on the order of a physician or other licensed eye care practitioner.