Ig Genes

Kidney B cell

Figure 5-2

Antibody Diversity

• Junctional Diversity – Imprecise DNA rearrangement – P-nucleotide Addition – N-region Diversification

Antibody Diversity • Junctional Diversity

– Imprecise DNA rearrangement – P-nucleotide Addition – N-region Diversification

• Somatic Mutation – Occurs after initial exposure to Ag – Mediated by AID (activation induced

cytidine deaminase)

Figure 5-19