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Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile...

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Page 1: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.
Page 2: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Immobilized Chiral Stationary PhasesNew Addition - CHIRALPAK® IG

Page 3: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Immobilization

OO

O

O

O

NH

O

O

NH

NH

O

OO

O

O

O

NH

O

O

NH

NH

O

OO

O

O

O

NH

O

O

NH

NH

O

Polymer

CSPCHIRALPAK IACHIRALPAK IBCHIRALPAK ICCHIRALPAK IDCHIRALPAK IECHIRALPAK IFCHIRALPAK IG

Proprietary Immobilization Techniques

Page 4: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Why Immobilized Phases?

● Stable to all normal phase, polar & reversed phase solvents … just like the achiral HPLC columns you use

● Solvent flexibility enhances the probability of success

● For preparative separations the wide range of compatible solvents allows best sample solubility

● Chiral Selectors previously not accessible, due to their solubility in the mobile phase, are now possible (CHIRALPAK IC / IE and ID)

Page 5: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Immobilized Stationary Phases

Attributes Coated Selectors Immobilized Selectors

Reliability Daicel authentic selectors Daicel authentic selectors

Robustness Restricted solvent selection Solvent flexibility

Reproducibility Affected by possible memory effects

Easy column regeneration

Loading capacity High loading capacity High loading capacity greatly improved due to analytesolubility

Page 6: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Innovative Column Technology

Page 7: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

NN

ClMeclizine

Column size 0.46mm ID x250mm longMobile phase n-Hexane/IPA/DEA=95/5/0.1Flow rate 1.0ml/min.Temperature 25℃Detection UV 254nm

OO γ-Phenyl-γ-butyrolactone

Column size 0.46mm ID x250mm longMobile phase n-Hexane/EtOH=90/10Flow rate 1.0ml/min.Temperature 25℃Detection UV 220nm

0 2 4 6 8 Retention Time [min]

10IA

IF

IB

ICID

IE

0 5 10 15 20 25 30Retention Time [min]

IA

IF

IB

ICID

IE

Complementarity CHIRALPAK IA

Page 8: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Complementarity CHIRALPAK IB & IC

NH

Cl

SNH2

O

ON

O

Indapamide

Column size 0.46mm x250mm longMobile phase n-Hexane/EtOH/DEA=50/50/0.1Flow rate 1.0ml/min.Temperature 25℃Detection UV 254nm

Column size 0.46mm x 250mm longMobile phase n-Hexane/IPA=80/20Flow rate 1.0ml/min.Temperature 25℃Detection UV 220nm

5-Benzylhydantoin NH

NH

O

O

0 4 8 12Retention Time [min]

IB

IF

IA

ICID

IE

0 5 10 15 20 25 30Retention Time [min]

IF

IA

IB

IDIE

IC

Page 9: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Cisapride

N

NH

O

NH2

OO

F

O

Cl

Column size 0.46mm x 250mm longMobile phase n-Hexane/IPA/DEA=50/50/0.1Flow rate 1.0ml/min.Temperature 25℃Detection UV 254nm

NH

MeOOCCl

COOEt

ONH2

Amlodipine

Column size 0.46mm x 25 mm longMobile phase n-hexane/IPA/MEA*=80/20/0.1Flow rate 1.0ml/min.Temperature 40℃Detection UV 254nm

*MEA=2-aminoethanolIA

IB

IC

IDIE

IF

0 4 8 12 16 20Retention Time [min]

IA

IBIC

ID

IEIF

Complementarity CHIRALPAK ID

Page 10: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Complementarity CHIRALPAK IE

0 5 10 15 20 25 30

Retention Time [min]

IE

IF

IA

IB

IC

ID

NN

Cl OOH

O

Column size 0.46mm ID x 250 mm longMobile phase n-Hexane/EtOH/AcOH/DEA=50/50/0.1/0.1Flow rate 1.0ml/min.Temperature 25℃Detection UV 230nm

Cetirizine

Page 11: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Complementarity CHIRALPAK IF

0 4 8 12 16 20

Retention Time [min]

IA

IB

IC

ID

IE

IFNH

NS

Cl

S

O

O

NH2 O O

Cl

Column size 0.46mm ID x 250mm longMobile phase n-Hexane/EtOH/DEA=50/50/0.1Flow rate 1.0ml/min.Temperature 25℃Detection UV 230nm

Methyclothiazide

Page 12: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Complementarity CHIRALPAK IG

Column size: 0.46cmI.D.×25cmLMobile phase: n-Hex/EtOH/DEA = 90/10/0.1Flow rate: 1.0ml/min.Temperature: 25℃Detection: UV275nmInjection: 5μL (1000mg/L in eluent)

Ritodrine

NEW

Page 13: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

CHIRALPACK IG Applications

Page 14: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Acidic Compounds – Normal phase

N-Cbz-Methionine

n-Hex/IPA/TFA=80/20/0.1

Pranoprofen

n-Hex/IPA/TFA=70/30/0.1

Condition: UV230nm, 0.46cmI.D.×25cmL, 1.0mL/min, 25℃

Page 15: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Basic Compounds – Normal Phase

Hydroxyzine(※1)

n-Hex/IPA/DEA=80/20/0.1

Oxprenolol(※1)

n-Hex/IPA/DEA=90/10/0.1

n-Hex/IPA/DEA=70/30/0.1

Dimetotiazine(※2)

Condition: UV230nm(※1), UV254nm(※2), 0.46cmI.D.×25cmL, 1.0mL/min, 25℃

Page 16: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

5-Methyl-5-phenylhydantoin

H2O/MeCN = 60/40

Separation Example – Reversed Phase

N-Cbz-Valine

Phosphate aq.(pH2)/MeCN = 60/40

Methychlothiazide

20mM NH3HCO3aq.(pH9 with DEA) /MeCN = 60/40

Condition:UV254nm, 0.46cmI.D.×25cmL, 1.0mL/min, 25℃

Page 17: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Complete Product Portfolio

Polysaccharides: CHIRALPAK® and CHIRALCEL®

Normal and Reversed Phases

Immobilized polysaccharides: IA, IB, IC, ID, IE, IF, IG

Coated polysaccharides: AD, AS, AY, AZ OB, OC, OD, OF, OG, OJ, OK, OZ

3-µm polysaccharides: IA, IB, IC, ID, IE , IF, IG

AD, AS, AY, AZ, OD, OJ, OZ, OX

Specialty Selectors Protein-based Phases -- CHIRALPAK AGP, HSA and CBH

Ligand Exchange: MA+, WH

Chiral Crown Ethers: CROWNPAK CR, CR+, CR-

Lindner Anion Exchange Phases: QD-AX, QN-AX

ZWIXTM (Zwitterionic Stationary Phases)

Page 18: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

Global Reach

Page 19: Immobilized Chiral Stationary Phases New Addition ...€¦ · Column size: 0.46cmI.D.×25cmL Mobile phase: n ... QD-AX, QN-AX ZWIX TM (Zwitterionic Stationary Phases) Global Reach.

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