Methods in Enzymology
Volume 136
Immobilized Enzymes and CellsPart C
Klaus Mosbach
CONTRIBUTORS TO VOLUME 136 ix
PREFACE Xiii
VOLUMES IN SERIES XVi i
Section I . Multistep Enzyme Systems and Coenzymes
1. Immobilized Active Coenzymes
MATS-OLLE MÄNSSON AN DKLAUS MOSBACH
3
2 . Continuous Enzymatic Transformation in an En- MARIA-REGINA KULA AN Dzyme-Membrane Reactor with Simultaneous CHRISTIAN WANDREY
9NADH Regeneratio n
3 . Coimmobilized System of NAD with Dehydro- YosHIMITSU YAMAZAKI AN Dgenases
HIDEKATSU MAEDA
2 1
4 . Polymerizable NAD Derivative and Model En- HIROSUKE OKADA AN Dzyme Reactor with Recycling of Polyethylene ITARU URABE
34Glycol-Bound NA D
5 . Adenosine 5'-Triphosphate Recycling in an En- HIDEO SUZUKI AN Dzyme Reactor Based on Aqueous Two-Phase YOSHIMITSU YAMAZAKI
45System s
6 . Alcohol Dehydrogenase Coimmobilized with Its KEITH J . LAIDLER AN DCoenzyme
M . ABDUL MAZID
56
7 . Recycling of NAD(P) by Multienzyme Systems T . M . S . CHANG
67Immobilized by Microencapsulation in Artificia lCell s
8 . Bioluminescent Assays Using Coimmobilized En- G . WIENHAUSEN ,zymes
L. J . KRICKA ,AND M . DELUCA
82
9. Nonseparation Enzyme Channeling Immunome- IAN GIBBONS ,tric Assays
RICHARD ARMENTA ,ROBERT K . DINELLO, AN DEDWIN F . ULLMAN
93
10 . Immobilized and Soluble Site-to-Site Directed En- NILS SIEGBAHN ,zyme Complexes Composed of Alcohol Dehy- MATS-OLLE MANSSON, AN Ddrogenase and Lactate Dehydrogenase
KLAUS MOSBACH
103
Section II. Immobilized Enzymes/Cells in Organic Synthesi s
11 . Overview
L. ANDERSSON ,M .-O . MÄNSSON, ANDK . MOSBACH
11 7
12 . Enzymatic Production of Optically Active Corn- ALEXANDER M . KLIBANO Vpounds in Biphasic Aqueous-Organic Systems AND BERNARD CAMBOU
11 7
13 . Two-Liquid Phase Biocatalytic Reactors
M . D . LILLY, S . HARBRON ,AND T. J . NARENDRANATHAN 13 8
14 . Enzyme-Catalyzed Steroid Transformations in GIACOMO CARREA ANDWater-Organic Solvent Two-Phase Systems
PIERO CREMONESI
150
15 . Deblocking in Peptide Synthesis with Immobilized G . P . ROYER
15 7Carboxypeptidase Y
16 . Use of Immobilized Achromobacter Protease I for KAZUYUKI MORIHARA ,Semisynthesis of Human Insulin
RYONOSUKE MUNEYUKI ,AND TATSUSHI OKA
162
17 . Application of Immobilized Aminopeptidases to G . FLEMINGER ANDthe Sequential Hydrolysis ofProline-Containing A . YARON
170Peptide s
18 . Peptide Synthesis Using Immobilized Proteases HANS-DIETER JAKUBKE AN DANDREAS KÖNNECKE
17 8
19. Activity and Conformation ofEnzymes in Reverse P . L . Luis' ANDMicellar Solutions
B . STEINMANN-HOFMANN
18 8
20. Design of Reversed Micellar Media for the Enzy- COL .IA LAANE ,matic Synthesis of Apolar Compounds
RIET HILHORST ,AND CEES VEEGER
21 6
21 . Disaccharide Synthesis with Immobilized /3-Ga- PER-OLOF LARSSON ,lactosidase
LARS HEDBYS ,SIGFRID SVENSSON, ANDKLAUS MOSBACH
230
22. Synthesis of Urea with Urease in Water-Organic LARRY G . BUTLER
234Solvent Mixture s
23 . Dextran Synthesis Using Immobilized Leuconos- P . MONSAN, F . PAUL ,toc mesenteroides Dextransucrase
D . AuRIOL, AND A . LOPEZ
23 9
24 . Preparation of Immobilized Milk Xanthine Oxi- JOHANNES TRAMPER
25 4dase and Application in Organic Synthese s
25. Enzymatic Regeneration of Adenosine 5'-Triphos- DEBBIE C . CRANS ,phate : Acetyl Phosphate, Phosphoenolpy- ROMAS J . KAZLAUSKAS ,ruvate, Methoxycarbonyl Phosphate, Dihy- BERNARD L . HIRSCHBEIN ,
droxyacetone Phosphate, 5-Phospho-a-D-ribo- CHI-HUEY WONG ,
syl Pyrophosphate, Uridine-5'-diphosphoglu- OBSIDIANA ABRIL, ANDcose
GEORGE M . WHITESIDES
263
26 . Equilibrium and Kinetically Controlled Synthesis VOLKER KASCHE ,
with Enzymes : Semisynthesis of Penicillins and URSULA HAUFLER,Peptides
AND LUTZ RIECHMANN
28 0
27 . Optical Resolution of dl-Menthol by Entrapped SABURO FUKUI AN DBiocatalysts
ATSUO TANAKA
29 3
28. Electroenzymatic and Electromicrobial Reduc- IORDANIS THANOS ,tion : Preparation of Chiral Compounds
JOHANN BADER ,
HELMUT GÜNTHER ,
STEFAN NEUMANN ,
FRIEDRICH KRAUSS, AN DHELMUT SIMON
30 2
29 . Long-Term Alkaloid Production by Immobilized BETTINA Ko pp
31 7Cells of Claviceps purpure a
30 . Cell Immobilization in the Production of Patulin G . M . GAUCHER AN Dand Penicillin by Penicillium urticae and Peni- L. A . BEHIE
32 9cillium chrysogenu m
31 . Isolation and Immobilization of Strictosidine Syn- URSULA PFITZNER AN Dthase
MEINHART H . ZENK
34 2
Section III . Enzyme Engineering (Enzyme Technology )
32. Overview
S . GESTRELIUS AN DK . MOSBACH
35 3
33 . Industrial-Scale Production and Application of VILLY J . JENSEN AN DImmobilized Glucose Isomerase
SUSANNE RUGH
35 6
34. Industrial Operation of Immobilized Enzymes
M . J . DANIELS
37 1
35 . Large-Scale Production of Photo-Cross-Linkable SHOGO NOJIMA AN DResin-Immobilized Yeast and Its Application to TOMIAKI YAMADA
38 0Industrial Ethanol Production
36 . Large-Scale Preparation of Calcium Alginate-Im- MINORU NAGASHIMA ,mobilized Yeast Cells and Its Application to In- MASAKI AZUMA ,dustrial Ethanol Production
SADAO NOGUCHI ,KEIICHI INUZUKA, AN DHIROTOSHI SAMEJIMA
394
37 . Regiospecific Interesterification of Triglyceride SHIGERU YAMANAKA AN Dwith Celite-Adsorbed Lipase
TAKASHI TANAKA
405
38 . Large-Scale Production and Application of Immo- J . L . BARET
41 1bilized Lactas e
39 . Continuous Treatment of Ultrahigh-Temperature HAROLD E . SWAISGOOD ,Sterilized Milk Using Immobilized Sulfhydryl VIOLETA G . JANOLINO, AN DOxidase
PAUL J . SKUDDER
423
40 . Production of Isomaltulose Using Immobilized PETER S . J . CHEETHAM
432Microbial Cell s
41. Production of L-Malic Acid by Immobilized Mi- ICHIRO CHIBATA ,crobial Cells
TETSUYA TOSA ,Kozo YAMAMOTO, AND1SAO TAKATA
45 5
42 . Industrial Production of L-Aspartic Acid Using MURRAY C . FUSEE
463Polyurethane-Immobilized Cells Containing As-partase
43 . Continuous L-Alanine Production Using Two Dif- ICHIRO CHIBATA ,ferent Immobilized Microbial Cell Preparations TETSUYA TOSA, AN Don an Industrial Scale
SATORU TAKAMATSU
472
44 . Immobilized Aminotransferases for Amino Acid J . DAVID ROZZELL
479Productio n
45 . Phenylalanine Production via Polyazetidine-Im- G . J . CALTON, L . L . WooD ,mobilized Escherichia coil: Optimization ofCell AND M . L . CAMPBELL
497Loading
46 . Production of Aspartame by Immobilized Ther- KIYOTAKA OYAMA ,moase
SHIGEAKI IRINO, AN DNORIO HAGI
503
47 . Production of 5'-Ribonucleotides Using Immobi- REINHOLD KELLER ,
lized 5'-Phosphodiesterase
MERTEN SCHLINGMANN ,AND ROLF WOERNLE
51 7
48 . Acrylamide Production Method Using Immobi- ICHIRO WATANABE
52 3lized Nitrilase-Containing Microbial Cell s
49 . Application of Immobilized Thiobacillus ferroox- T . MURAYAMA, Y . KONNO ,idans for Large-Scale Treatment of Acid Mine T . SAKATA, AN DDrainage
T . IMAIZUMI
53 0
AUTHOR INDEX 54 1
SUBJECT INDEX 557