Miracles and misadventuresMiracles and misadventuresImmune diseasesImmune diseases
Function of the Immune SystemFunction of the Immune System
Denis WakefieldDenis Wakefield
School of Pathology UNSW, AustraliaSchool of Pathology UNSW, Australia
Immune diseasesImmune diseases
School of Pathology UNSW, Australia
• Infections
• Allergy
• Cancer
• Autoimmunity
Immune diseasesImmune diseasesThe war withinThe war within
School of Pathology UNSW, Australia
• Physical barriers
• Cells
• Molecules
Immune diseasesImmune diseases
School of Pathology UNSW, Australia
• Infections
• Allergy
• Cancer
• Autoimmunity
Miracles and misadventuresMiracles and misadventuresImmune diseasesImmune diseases
Autoimmunity and AllergyAutoimmunity and Allergy
Denis WakefieldDenis Wakefield
School of Pathology UNSW, AustraliaSchool of Pathology UNSW, Australia
Immune diseasesImmune diseases
School of Pathology UNSW, Australia
• Autoimmunity
• Allergy
• Immunodeficiency
• Transplantation
AUTOIMMUNE DISEASEAUTOIMMUNE DISEASE
OUTLINE
DEFINITIONCRITERIA FOR AIDSPECTRUM OF AIDPATHOGENESISGENES, GERMS AND GENDERAUTOANTIBODIESEXAMPLES OF AID
AUTOIMMUNE DISEASEAUTOIMMUNE DISEASE
DEFINITION
HARMFUL IMMUNOLOGICAL PROCESS
CHARACTERISED BY EITHER ANTIBODY OR CELL MEDIATED REACTION
DIRECTED TOWARDS SELF COMPONENTS
AUTOIMMUNE DISEASEAUTOIMMUNE DISEASE
CRITERIA
PRESENCE OF AUTOIMMUNE RESPONSE
IMMUNISATION PRODUCES DISEASE
PASSIVE TRANSFER BY Ab OR LYMPHOCYTES
RESPONDS TO IMMUNOSUPPRESSION
AutoimmunityAutoimmunity
School of Pathology UNSW, Australia
Autoimmunity: sex differencesAutoimmunity: sex differences
School of Pathology UNSW, Australia
AUTOIMMUNE DISEASESAUTOIMMUNE DISEASESPATHOGENESIS
ANTIBODY MEDIATED
IMMUNE COMPLEX MEDIATED
CELL MEDIATED
Organ specific V Organ non-specific
AUTOIMMUNE DISEASESAUTOIMMUNE DISEASES
ANTIBODY MEDIATED
THYROID-Thyrotoxicosis
GASTRIC- PERNICIOUS ANAEMIA
MYASTHENIA GRAVIS
Autoimmune Thyroid Autoimmune Thyroid diseasaediseasae
School of Pathology UNSW, Australia
Pernicious anaemia
Macrocytic RBC
Hypersegmented PMN
MyastheniaMyasthenia GravisGravis AUTOIMMUNE DISEASES
IMMUNE COMPLEX MEDIATED
S.L.E.R.A.VASCULITIS
Systemic Lupus Systemic Lupus ErythematosisErythematosis
Laboratory of Ocular immunology UNSW, Australia
A 27 year old woman presented
with a visual field defect in the L
eye, head-aches and a facial rash.
She had a positive ANA and
proteinuria.
Rheumatoid arthritisRheumatoid arthritis
School of Pathology UNSW, Australia
Systemic Systemic VasculitisVasculitis
Rheumatoid arthritis
Wegeners granulomatosis
Relapsing polychondritis
Polyarteritis nodosa
Inflammatory bowel disease
Systemic vasculitis
Systemic infection
AUTOIMMUNE DISEASESAUTOIMMUNE DISEASES
CELL MEDIATED DISEASES
DIABETES MELLITUS
MULTIPLE SCLEROSIS
SjogrensSjogrens syndromesyndrome
School of Pathology UNSW, Australia
SchirmersSchirmers testtest
AllergyDefinitions
Type 1 hypersensitivity
Hightened state of reactivity
Atopy- genetic predisposition to allergy
Hayfever, Asthma, eczema
School of Pathology UNSW, Australia
Allergic Allergic conjuntivitisconjuntivitis
School of Pathology UNSW, Australia
AngioedemaAngioedema
School of Pathology UNSW, Australia
Asthma
School of Pathology UNSW, Australia
Allergic dermatitis: Allergic dermatitis: excemaexcema
School of Pathology UNSW, Australia
AllergyCommon Allergens
House dust and house dust mitePollensAnimal dandersMoulds and fungiiFoodsDrugsInsects
School of Pathology UNSW, Australia
Allergy-HDM
TransplantationAims
• Preservation of organ function
• Preservation of quality of life
• Prevention of rejection-acute/chronic
• Prevention of treatment complications
School of Pathology UNSW, Australia
Transplantation
• Kidney, heart, lung, liver
• Bone marrow
• Cornea
School of Pathology UNSW, Australia
Transplantation
Key Elements• Foreign HLA antigens• Immune response• Rejection• Life long immunosupression
School of Pathology UNSW, Australia
Immunosuppression
Transplantation
• Steroids
• Imuran, cyclosporin, mycophenolate
• Anti-Tcell antibody
School of Pathology UNSW, Australia
Immune diseases
Denis Wakefield
School of Pathology UNSW, Australia
AutoimmunityAutoimmunity AutoimmunityAutoimmunity
AutoimmunityAutoimmunity
Organ Specific v NonOrgan Specific v Non--Organ specificOrgan specific
ThyroidPancreasAdrenalMuscle
JointsBlood vesselsExocrine glandsNerves
Autoimmune thyroid diseaseAutoimmune thyroid disease
AUTOIMMUNE DISEASES Immune diseases
School of Pathology UNSW, Australia
AutoimmunityAutoimmunity
School of Pathology UNSW, Australia
MS and AutoimmunityMS and Autoimmunity
School of Pathology UNSW, Australia