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Immune response to viruses
Yoavanit Srivaro M.D.
Outlines
• Definition and Properties of a Virus
• Viral replication
• Innate immune response to viral infection
• Adaptive immune response to viral infection
• Immune Evasion by Viruses
Outlines
• Definition and Properties of a Virus
• Viral replication
• Innate immune response to viral infection
• Adaptive immune response to viral infection
• Immune Evasion by Viruses
Definition and Properties of a Virus
• Filterable agents
• Obligate intracellular parasites
• Can not make energy/proteins without host cell
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
Definition and Properties of a Virus
• Viral genomes may be RNA or DNA
• Viruses have a naked capsid or an envelope
morphology
• Viral components are assembled and do not
replicate by “division.”
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-4 Virion structure.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-1 Components of the basic virion.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-4 Virion structure.
FIGURE 36-4 Virion structure.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
FIGURE 36-4 Virion structure.
Murray PR, Rosenthal KS, Pfaller MA, editors. Medical microbiology. 8th ed. Philadelphia: Elsevier Saunder; 2014.
Outlines
• Definition and Properties of a Virus
• Viral replication
• Innate immune response to viral infection
• Adaptive immune response to viral infection
• Immune Evasion by Viruses
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
Virus Receptor
Epstein-Barr virus Complement receptor 2 (CR2)
Influenza virus Sialic residue on cell surface glycoprotein
Rhinovirus Intracellular adhesion molecule:ICAMs
Vaccinia virus Epidermal growth factor receptor
Cellular receptor for viruses entry
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
FIGURE 36-8 A general scheme of viral replication
Peakman M, Vergani D, editors. Basic and Clinical Immunology. 2nd ed. Philadelphia: Elsevier Saunders; 2009.
Scott N. Mueller BTR. Immune responses to viruses. In: Rich RR, Fleisher TA, William T. Shearer HW, Jr. S, Frew AJ, Weyand CM, editors. Clinical immunology principle and practice. 3rd ed. Philadelphia: Mosby Elsevier 2008. p. 421-31.
Outlines
• Definition and Properties of a Virus
• Viral replication
• Innate immune response to viral infection
• Adaptive immune response to viral infection
• Immune Evasion by Viruses
Innate immune response to viral infection
• Epithelial barrier
• Early non-specific or innate immune
– Interferon (IFN)
• Type I IFNs (IFN α and IFN β)
• Type II IFN (IFN γ)
– Natural killer cells
– Macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Innate immune response to viral infection
• Epithelial barrier
• Early non-specific or innate immune
– Interferon (IFN)
• Type I IFNs (IFN α and IFN β)
• Type II IFN (IFN γ)
– Natural killer cells
– Macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-5 Epithelial barriers.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-5 Epithelial barriers.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Innate immune response to viral infection
• Epithelial barrier
• Early non-specific or innate immune
– Interferon (IFN)
• Type I IFNs (IFN α and IFN β)
• Type II IFN (IFN γ)
– Natural killer cells
– Macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Type I interferons
• IFN-α is produced by
- Plasmacytoid dendritic cells
- Mononuclear phagocytes
• IFN-β is produced by many cell types
Interferon: interfere with viral infection
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 13.1 Pathways by which type I IFN production
Plasmacytoid DCs• Produce high levels
of type I IFN • Without themselves
becoming infected
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
FIGURE 4-16 Mechanisms of induction of type I interferons by viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-16 Mechanisms of induction of type I interferons by viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-16 Mechanisms of induction of type I interferons by viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-16 Mechanisms of induction of type I interferons by viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-16 Mechanisms of induction of type I interferons by viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 4-17 Biologic actions of type I interferons
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed.Philadelphia Elsevier Saunders:;2015.
Innate immune response to viral infection
• Epithelial barrier
• Early non-specific or innate immune
– Interferon (IFN)
• Type I IFNs (IFN α and IFN β)
• Type II IFN (IFN γ)
– Natural killer cells
– Macrophages
FIGURE 4-7 Functions of NK cells
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed.Philadelphia Elsevier Saunders:;2015.
Important mechanism of immunity against viruses early in the course of infection.
Innate immune response to viral infection
• Epithelial barrier
• Early non-specific or innate immune
– Interferon (IFN)
• Type I IFNs (IFN α and IFN β)
• Type II IFN (IFN γ)
– Natural killer cells
– Macrophages
Macrophages
• Phagocytosis of virus and virus-infected cells;
• Killing of virus-infected cells; and
• Production of antiviral molecules
: TNFα, nitric oxide, and IFNα.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Adaptive immune response to viral infection
• Antiviral antibodies
• Cytotoxic T lymphocytes (CTLs)
• Helper T (Th) cells
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Adaptive immune response to viral infection
• Antiviral antibodies
• Cytotoxic T lymphocytes (CTLs)
• Helper T (Th) cells
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Antiviral antibodies
• Secretory IgA: neutralizing antibody
- Respiratory tract
- Intestinal tract
• IgG
- ADCC
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Antiviral antibodies
• Secretory IgA: neutralizing antibody
- Respiratory tract
- Intestinal tract
• IgG
- ADCC
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Fig. 13.6 Effector mechanisms by which adaptive responses combat virus replication
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
1. Blocks binding to cell2. Blocks entry into cell
Fig. 13.6 Effector mechanisms by which adaptive responses combat virus replication
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
1. Activate membrane attack complex lysis2. Opsonization
Fig. 13.6 Effector mechanisms by which adaptive responses combat virus replication
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Antibody bound to infected cells ADCC
Adaptive immune response to viral infection
• Antiviral antibodies
• Cytotoxic T lymphocytes (CTLs)
• Helper T (Th) cells
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
FIGURE 16-7 Adaptive immune responses against viruses.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 11-6 Mechanisms of CTL-mediated killing of target cells..
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 11-6 Mechanisms of CTL-mediated killing of target cells..
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 11-6 Mechanisms of CTL-mediated killing of target cells..
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 11-6 Mechanisms of CTL-mediated killing of target cells..
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Fig. 13.6 Effector mechanisms by which adaptive responses combat virus replication
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Adaptive immune response to viral infection
• Antiviral antibodies
• Cytotoxic T lymphocytes (CTLs)
• Helper T (Th) cells
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Helper T (Th) cells
• CD4+ T cell-derived IL-2: CD8+ T cell growth factor
• CD4+ T cell-derived chemokines: recruit CD8+ T to
site of infection
• CD4+ T cells secrete IFNγ and TNFα to recruit and
activate macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Helper T (Th) cells
• CD4+ T cell-derived IL-2: CD8+ T cell growth factor
• CD4+ T cell-derived chemokines: recruit CD8+ T to
site of infection
• CD4+ T cells secrete IFNγ and TNFα to recruit and
activate macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Helper T (Th) cells
• CD4+ T cell-derived IL-2: CD8+ T cell growth factor
• CD4+ T cell-derived chemokines: recruit CD8+ T to
site of infection
• CD4+ T cells secrete IFNγ and TNFα to recruit and
activate macrophages
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Fig. 13.6 Effector mechanisms by which adaptive responses combat virus replication
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
FIGURE 16-7 Innate and adaptive immune responses against viruses.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 16-7 Innate and adaptive immune responses against viruses.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 16-7 Innate and adaptive immune responses against viruses.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE 16-7 Innate and adaptive immune responses against viruses.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Outlines
• Definition and Properties of a Virus
• Viral replication
• Innate immune response to viral infection
• Adaptive immune response to viral infection
• Immune Evasion by Viruses
Mechanism of Immune Evasion Examples
Antigenic variation Influenza, rhinovirus, HIV
Inhibition of antigen processingBlockade of TAP transporterRemoval of class I moleculesfrom the ER
Herpes simplex virus (HSV)Cytomegalovirus (CMV)
Production of “decoy” MHCmolecules to inhibit NK cells
Cytomegalovirus (murine)
Production of cytokine receptorhomologues
Vaccinia, poxviruses (IL-1, IFN-γ)Cytomegalovirus (chemokine)
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Figure 11-29Biochemistry Sixth Edition
2007 W.H> Freeman and Company
Influenza Virus
Figure 11-29Biochemistry Sixth Edition
2007 W.H> Freeman and Company
Influenza Virus
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
Borrow P, Nash AA. Immunity to viruses. In: Male D, Brostoff J, Roth D, Roitt I, editors. Immunology. 8th ed. Philadelphia: Elsevier Saunders; 2013. p. 211-22.
FIGURE 16-8 Generation of new influenza virus strainsby genetic recombination (antigenic shift).
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Antigenic variation Influenza, rhinovirus, HIV
Inhibition of antigen processingBlockade of TAP transporterRemoval of class I moleculesfrom the ER
Herpes simplex virus (HSV)Cytomegalovirus (CMV)
Production of “decoy” MHCmolecules to inhibit NK cells
Cytomegalovirus (murine)
Production of cytokine receptorhomologues
Vaccinia, poxviruses (IL-1, IFN-γ)Cytomegalovirus (chemokine)
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Antigenic variation Influenza, rhinovirus, HIV
Inhibition of antigen processingBlockade of TAP transporterRemoval of class I moleculesfrom the ER
Herpes simplex virus (HSV)Cytomegalovirus (CMV)
Production of “decoy” MHCmolecules to inhibit NK cells
Cytomegalovirus (murine)
Production of cytokine receptorhomologues
Vaccinia, poxviruses (IL-1, IFN-γ)Cytomegalovirus (chemokine)
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE16-9 Mechanisms by which viruses inhibit antigen processing & presentation.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE16-9 Mechanisms by which viruses inhibit antigen processing & presentation.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE16-9 Mechanisms by which viruses inhibit antigen processing & presentation.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE16-9 Mechanisms by which viruses inhibit antigen processing & presentation.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
FIGURE16-9 Mechanisms by which viruses inhibit antigen processing & presentation.
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Antigenic variation Influenza, rhinovirus, HIV
Inhibition of antigen processingBlockade of TAP transporterRemoval of class I moleculesfrom the ER
Herpes simplex virus (HSV)Cytomegalovirus (CMV)
Production of “decoy” MHCmolecules to inhibit NK cells
Cytomegalovirus (murine)
Production of cytokine receptorhomologues
Vaccinia, poxviruses (IL-1, IFN-γ)Cytomegalovirus (chemokine)
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Production of immunosuppressivecytokine
Epstein-Barr (IL-10)
Infection and death or functionalimpairment of immune cells
HIV
Inhibition of complementactivation
Recruitment of factor H Incorporation of CD59 in viral envelope
HIVHIV, vaccinia, human CMV
Inhibition of innate immunityInhibition of access to RIG-IRNA sensorInhibition of PKR (signaling byIFN receptor
Vaccinia, HIV
HIV, HCV, HSV, polio
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Production of immunosuppressivecytokine
Epstein-Barr (IL-10)
Infection and death or functionalimpairment of immune cells
HIV
Inhibition of complementactivation
Recruitment of factor H Incorporation of CD59 in viral envelope
HIVHIV, vaccinia, human CMV
Inhibition of innate immunityInhibition of access to RIG-IRNA sensorInhibition of PKR (signaling byIFN receptor
Vaccinia, HIV
HIV, HCV, HSV, polio
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Production of immunosuppressivecytokine
Epstein-Barr (IL-10)
Infection and death or functionalimpairment of immune cells
HIV
Inhibition of complementactivation
Recruitment of factor H Incorporation of CD59 in viral envelope
HIVHIV, vaccinia, human CMV
Inhibition of innate immunityInhibition of access to RIG-IRNA sensorInhibition of PKR (signaling byIFN receptor
Vaccinia, HIV
HIV, HCV, HSV, polio
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Mechanism of Immune Evasion Examples
Production of immunosuppressivecytokine
Epstein-Barr (IL-10)
Infection and death or functionalimpairment of immune cells
HIV
Inhibition of complementactivation
Recruitment of factor H Incorporation of CD59 in viral envelope
HIVHIV, vaccinia, human CMV
Inhibition of innate immunityInhibition of access to RIG-IRNA sensorInhibition of PKR (signaling byIFN receptor
Vaccinia, HIV
HIV, HCV, HSV, polio
TABLE 16-3 Mechanisms of Immune Evasion by Viruses
Abbas AK, Lichtman AH, Pillai S, editors. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders;2015.
Summary
• Innate immune mechanisms restrict the early stages
of infection and delay spread of virus.
: Interferon
: NK cells
: Macrophages
Summary
• As a viral infection proceeds, the adaptive (specific) immune response unfolds.
: Ab & complement limit viral spread &
reinfection
: CD8+ CTLs destroy virus infected cells
: CD4+ T cells are a major effector cell
population
Summary
• Viruses have evolved strategies to evade the immune response.
: Virus latency & antigenic variation are the
most effective mechanisms.
: Many DNA viruses have strategies to control
expression of MHC molecules.