Immune Risk Phenotype

Dr. Gabriele Rumi

Effect of the genetic background and aging on the immune system

Interplay between the IRP, low grade inflammation, and cognitive impairment in mortality

From the clinical perspective, the percentage of the cytotoxic CD8+ CD28– T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P = 0.032).

Schirmer M, Goldberger C, Würzner R, Duftner C, Pfeiffer KP, Clausen J,Neumayr G, Falkenbach A. Arthritis Res. 2002;4(1):71-6. Epub 2001 Oct 16. PubMed

Circulating cytotoxic CD8(+) CD28(-) T cells in ankylosing spondylitis.

Immunological biomarkers of ageing in man changes in both innate and adaptive immunity are associated with health and longevity