THIS MEDICAL AND SCIENTIFIC INFORMATION IS PROVIDED FOR THE USE OF PHYSICIANS AND OTHER LICENSED HEALTH CARE PRACTITIONERS ONLY TO USE AS A BASIS FOR DETERMINING WHETHER OR NOT TO RECOMMEND THESE PRODUCTS TO THEIR PATIENTS. THIS INFORMATION IS NOT FOR USE BY CONSUMERS. THE PRODUCTS DESCRIBED HERE ARE NOT INTENDED FOR USE BY CONSUMERS AS A MEANS TO CURE, TREAT, PREVENT, DIAGNOSE, OR MITIGATE ANY DISEASE OR MEDICAL CONDITION. ImmunoPCTN® Overview: ImmunoPCTN® promotes Cellular Health and increases Oncological Nutritional Support. Discussion Four major methods of inhibiting uncontrolled cell division includes: reduction of oxidative damage, minimize overproduction of inflammatory biochemicals, strengthen immunity and enhance detoxification of environmental toxins. ImmunoPCTN® is a polybotanical formula created for the promotion of cellular health and to discourage uncontrolled cell division.. ImmunoPCTN® contains scientifically evaluated natural compounds including: Curcumin, Modified Citrus Pectin, and extracts from medicinal reishi mushroom, green tea, grape seed, boswellia and pomegranate.
lipooxygenase (5-LOX) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)2.
This ancient spice also induces cell-cycle arrest and natural cell death (apoptosis). However, not
all curcuminoids have the same potency for anti-oxidative and anti-inflammatory effectiveness.
C3 Curcumin Complex® is used in ImmunoPCTN® was evaluated and certified for its
therapeutic efficacy.
Modified Citrus Pectin (MCP)
Modified Citrus Pectin is a complex water soluble non-digestible polysaccharide, which is easily
absorbed by human body, prepared from the peel and pulp of citrus fruits by the
depolymerization of un-absorbable citrus pectin polysaccharides. Several studies confirmed
MCP activity against breast, prostate, and colon abnormalities3. MCP also demonstrated strong
activity with uncontrolled cell division. Most importantly, combination treatment of MCP with
other polybotanical supplements further suppressed breast and prostate abnormal cell activity4.
Finally, MCP increased the prostate-specific antigen doubling time (PSADT) in men with
prostate cancer in the clinical study5. In summary, combination of MCP with other natural
compounds further enhances therapeutic efficacy of the ImmunoPCTN formula.
Reishi mushroom (Ganoderma lucidum, Lingzhi)
Reishi mushroom has been used for centuries in Asian countries to improve health and promote
longevity. Several studies suggested that Reishi can be used for the prevention and co-
management of many diseases including those in oncology6. Reishi possesses cytotoxic,
cytostatic, anti-metastatic, anti-inflammatory but it is likely best known for it’s immune
activating effects. This medicinal mushroom has shown in numerous studies to activate specific
immune cells including: macrophages, T-helper and Natural Killer (NK) cells7.
Green tea (Camellia sinensis)
Green tea is the second most popular beverage in the world. Not surprisingly several
epidemiological studies suggest that the consumption of green tea is associated with the health
promoting and chemo preventative effects8. The health promoting effects of green tea extracts
are associated with polyphenols, mainly catechins with the most abundant and active catechin,
epigallocatechin-3-gallate (EGCG). The major effects of green tea polyphenols have been
associated with their anti-oxidative activities and the induction of detoxification enzymes which
promote cellular health by removing harmful reactive oxygen species (ROS) and possible
carcinogens. In addition, green tea polyphenols also interferes with several signaling molecules
including the enzyme ortnithine decarboxylase involved uncontrolled division of damaged cells.
In addition, polyphenols from green tea have demonstrated to induce “cell suicide” of damaged
cells and encourages the protection of damaged DNA9. Moreover, a combination of green tea
polyphenols with curcumin markedly improves the low bioavailability of curcumin and further
suppress’ the growth of unhealthy cells10.
Modified CitrusPectin
Reishi mushroom
Curcumin
Green TeaExtract
Boswellia SerrataExtract
Grape SeedExtract
ImmunoPCTN®
NF-κB, COX-2,
PLA2, 5-LOX,
abnormal cell division
galectin-3
Macrophages,
T-helper, NK cells
anti--oxidative
anti-inflammatory
PSADT
anti-oxidativeLOX
anti-oxidative
detoxification
Grape Seed Extract
Grape seed extract (GSE), prepared from grape (Vitis vinifera) seeds, is a complex mixture of
polyphenols containing dimers, trimers, and other oligomers of catechins known as the
proanthocyanidins11. Several studies demonstrated GSE’s broad spectrum of biological benefits
including anti-oxidative activity against oxidative stress and degenerative conditions including
cardiovascular dysfunctions, acute and chronic stress, gastrointestinal distress, neurological
disorders, pancreatitis, and cancer12. GSE is known for its potent levels of the antioxidant
proanthocyanidins, contains a broad spectrum of biological benefits including anti-oxidative,
anti-inflammatory, anti-microbial and cardio-protective13. One large human study found a 41%
reduction in excessive cell proliferation of abnormal prostate cells only in men consuming Grape
Seed Extract supplement compared to other nutrients.
On the other hand, GSE exhibits selective cytotoxicity against human cancer cells, while not
affecting normal cells. As in the case of green tea catechins, in addition to anti-oxidant and anti-
inflammatory activities, GSE also suppressed growth of unwanted cells, induced apoptosis and
suppressed spreading of aberrant cells.
Boswellia (Boswellia serrate)
Extracts isolated from the Indian plant Boswellia serrata (BSE) contain different boswelic acids
as the major active compounds14. Studies on the cellular level reveal that BSE induce immune
response, induce programmed death of cancer cells and likely most studied for its ability to
inhibit over production of the inflammatory chemical lipooxygenase. (LOX). Moreover, human
studies suggest BSE for the management of rheumatoid arthritis, osteoarthritis, ulcerative, colitis,
Crohn´s disease, bronchial asthma and brain and other cancers15.
Pomegranate (Punica granatum)
Extracts from the pomegranate fruit contain several polyphenols and anthocynidins.
Pomegranate extracts (PME) demonstrated anti-oxidant and anti-inflammatory activities, and
suppressed growth and invasive behavior in several experimental studies. In addition to the
chemopreventative effects, PME also improved cardiovascular health and demonstrated anti-
aging, anti-diabetes and anti-obesity effects16. Preclinical in vitro and in vivo studies
demonstrated strong activity of PME against fast growing cell lines and in animal cancer
models17. However, the evidence of clinical effectiveness was reduced because of the poor
quality of published clinical studies. On the other hand, exploratory clinical studies
investigating pomegranate found a trend of efficacy in increasing PSADT in patients with
prostate cancer18.
Recommended dose: 3 pills in the morning and 3 pill at night, away from food.
References.
1. Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012; 39: 283–99. 2. Jurenka, JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa, a review of preclinical and clinical research. Altern Med Rev. 2009; 14: 141–53. 3. Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res. 2009; 344: 1788–91. 4. Jiang J, Eliaz I, Sliva D. Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integr Cancer Ther. 2013; 12: 145-52. 5. Guess BW, Scholz MC, Strum SB, Lam RY, Johnson HJ, Jennrich RI. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis. 2003; 6: 301-4. 6. Sliva D. Medicinal potential of Ganoderma lucidum. In: Applied Mycology, (CAB International, Eds.: M. Rai and P.D. Bridge), 2009, pp 173-196.
8. Cheng S, Sliva D. Ganoderma lucidum for cancer treatment – We are close but still not there. Integr Cancer Ther. 2015; 14: 249-57. 9. Yang CS, Wang X, Lu G, Picinich SC. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 2009; 9: 429–39. 10. Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H. New role of (-)-epicatechin in enhancing the induction of growth inhibition and apoptosis in human lung cancer cells by curcumin. Cancer Prev Res. 2010; 3: 953–62. 11. Kennedy JA, Hayasaka Y, Vidal S, Waters EJ, Jones GP. Composition of grape skin proanthocyanidins at different stages of berry development. J Agric Food Chem 2001; 49: 5348–55. 12. Bagchi D, Swaroop A, Preuss HG, Bagchi M. Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin: an overview. Mutat Res. 2014; 768: 69-73. 13. Kaur M, Agarwal C, Agarwal R. Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. J Nutr. 2009; 139: 1806S–12S. 14. Poeckel D, Werz O. Boswellic acids: biological actions and molecular targets. Curr Med Chem. 2006; 13: 3359-69. 15. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. Frankincense (rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. J Tradit Complement Med. 2013; 3: 221-6. 16. Johanningsmeier SD, Harris GK. Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol. 2011; 2: 181-201 17. Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer. 2009; 61: 811-5. 18. Turrini E, Ferruzzi L, Fimognari C. Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxid Med Cell Longev. 2015; 2015: 938475.
