day one wednesday may 28 8:00 am – meeting registration opens 10:00 pm McArthur Ballroom Foyer 12:30 pm – flow cytometry workshop 6:00 pm Chair: Lawrence S. Lamb, Jr. 12:30 pm – session i: standardization of cytometric testing 2:30 pm Speakers Jan Gratama Standardization of enumeration of antigen-specific cd8+ T cells by tetramer technology Nicholas Greco Characterization of cord blood CD34+ cell subpopulations: appearance of apoptotic cells after cryopreservation Michael Keeney Issues in standardization of CD34 counts in hematopoeitic transplantation 2:30 pm – session ii: report from the working group on high speed cell sorting for clinical use 3:30 pm Speakers Gerald Marti David Coder 4:00 pm – session iii: cytometric applications in biotherapy/immunotherapy 6:00 pm Chair: Maryalice Stetler-Stevenson, MD, PhD., National Cancer Institute, Bethesda, MD, USA Speakers Sivasubramanian Baskar Immunotherapy of human follicular lymphoma: T cell responses to tumor associated antigens Robert Kreitman Recombinant immunotoxins for treatment of hematologic malignancies Mark Lowdell Flow cytometric assays to monitor immune responses to leukaemia Maryalice Stetler-Stevenson The role of clinical flow cytometry in antibody based therapies McArthur Ballroom Salon 3 7:00 pm – cGTP workshop 10:00 pm Chairs: Janice Davis-Sproul and John McMannis Speakers Joyce Frey-Vasconcells Introduction to the regulation of cells and tissues Ruth Solomon Background and registration final rule Donor suitability Current good tissue practice Additional requirements for “361” HCT/Ps McArthur Ballroom Salons 1 and 2 workshops page 12
Transcript
day one wednesday may 28
8:00 am – meeting registration opens10:00 pm McArthur Ballroom Foyer
12:30 pm – flow cytometry workshop6:00 pm Chair: Lawrence S. Lamb, Jr.
Jan GratamaStandardization of enumeration of antigen-specific cd8+ T cells by tetramer technology
Nicholas GrecoCharacterization of cord blood CD34+ cell subpopulations: appearance of apoptotic cellsafter cryopreservation
Michael KeeneyIssues in standardization of CD34 counts in hematopoeitic transplantation
2:30 pm – session ii: report from the working group on high speed cell sorting for clinical use3:30 pm Speakers
Gerald Marti
David Coder
4:00 pm – session iii: cytometric applications in biotherapy/immunotherapy6:00 pm Chair: Maryalice Stetler-Stevenson, MD, PhD., National Cancer Institute, Bethesda, MD, USA
Speakers
Sivasubramanian BaskarImmunotherapy of human follicular lymphoma: T cell responses to tumor associated antigens
Robert KreitmanRecombinant immunotoxins for treatment of hematologic malignancies
Mark Lowdell Flow cytometric assays to monitor immune responses to leukaemia
Maryalice Stetler-StevensonThe role of clinical flow cytometry in antibody based therapies
McArthur Ballroom Salon 3
7:00 pm – cGTP workshop
10:00 pm Chairs: Janice Davis-Sproul and John McMannis
Speakers
Joyce Frey-VasconcellsIntroduction to the regulation of cells and tissuesRuth SolomonBackground and registration final ruleDonor suitabilityCurrent good tissue practiceAdditional requirements for “361” HCT/Ps
McArthur Ballroom Salons 1 and 2
workshops
page 12
page 13
7:30 am – cGTP Workshop4:45 pm Chairs: Janice Davis-Sproul and John McMannis
8:00 am – Development Of A Quality Management Plan9:15 am
PanelDonna Przepiorka (Chair), Shelley Heimfeld, Linda Kelley, Mary Malarkey, Donna Regan
10:00 am – Adverse Reactions/Deviation Reports/Corrective Actions11:15 am
PanelCindy Elliott (Chair), Brenda Alder, Diane Kadidlo, Mary Malarkey, Robert Preti, Elizabeth Read
1:00 pm – Validation Of Computerized Systems2:15 pm
PanelScott Burger (Chair), Janis Halvorsen, Safa Karandish, Elizabeth Read, Linda Weir
3:00 pm – Product Import And Export Issues4:15 pm
PanelChatchada Karanes (Chair), Carolyn Keever-Taylor, Mary Malarkey, Michael StrongMcArthur Ballroom Salons 1 and 2
12:00 noon – isct exhibit and poster set-up10:00 pm Frank Lloyd Wright Ballroom
5:00 pm – miltenyi biotec corporate symposium7:00 pm The Potential of Cellular Engineering and Therapy
Chair: Jeffrey MillerSpeakersR. SorgClinical-scale generation of dendritic cells for immunotherapyG. HartmannImmunotherapy of H&N tumorsJ. MillerAdoptive immunotherapy using haploidentical natural killer (NK) cell infusions:Implications for cancer and stem cell transplantationK. KomanduriAdoptive immunotherapy with CMV-specific T cellsA. KocherStem cell support in heart disease
McArthur Ballroom Salon 3
7:00 pm – welcome reception8:00 pm Gold Room
8:00 pm – baxter oncology, dynal biotech and xcyte therapies corporate symposium10:00 pm Emerging strategies utilizing cellular therapies to rebuild tissue and immune function
in patients: from laboratory to the clinicChair: John Barrett
SpeakersDoug LosordoThe role of CD34+ cells in coronary artery disease and peripheral vascular diseaseØystein ÅmellemThe identification and isolation of antigen specific T cellsMark BonyhadiGrowing T cells for immunotherapy: The process, the biology, current and future clinical applications
McArthur Ballroom Salon 3
day two thursday may 29
day three friday may 30
7:00 am –8:00 am
8:00 am –9:20 am
plenary session iImmunotherapy and Tumor Evaluation/MRDChair: John BarrettLawrence Fong Dendritic cells as a cellular vaccine for tumor immunotherapyKlaus Pantel Molecular signatures related to bone marrow micrometastasis in breast cancerMcArthur Ballroom Salon 4
isct annual general meeting McArthur Ballroom Salon 4coffee break Frank Lloyd Wright Ballroom
9:20 am –9:55 am
lunchFrank Lloyd Wright Ballroom
12:10 pm – 1:10 pm
9:55 am –12:10 pm
1:10 pm –2:10 pm
educational session 1Immunotherapy
Chair: Robert VonderheideJeffrey MolldremMcArthur Ballroom Salon 1
educational session 2Tumor Evaluation/MRD
Chairs: Klaus Pantel andGunnar KvalheimMcArthur Ballroom Salon 2
educational session 3AABB: HPC Donor and Recipient Safety
Jay Herman, Chatchada Karanes,Scott Rowley and Edward Snyder
McArthur Ballroom Salon 3
workshop 1ImmunotherapyJeffrey Molldrem
McArthur Ballroom Salon 1
workshop 2Tumor Evaluation/MRDChairs: Klaus Pantel andGunnar KvalheimMcArthur Ballroom Salon 2
2:15 pm –3:15 pm
TB 1Storage andCryopreservation ofCell Products
Carlos LeeMcArthur BallroomSalon 5
TB 2Evaluation of theApheresis Product– From Collectionto Reinfusion
TB 5Analysis of Immu-noreconstitutionPost-Transplant,i.e., Spectratyping,TREC Assays,Eli SpotsMatthias EyrichGrand
TB 6Meet the FACTExperts
Linda Kelley, Shelly Heimfeldand Helen HeslopCanyon
program
simultaneous plenary session aImmunotherapyChair: Jeffrey MolldremKrishna KomanduriCMV-specific immune reconstitution and immunodominanceRobert NegrinReal-time modeling of adoptive immunotherapyRobert VonderheideAdoptive immunotherapy targeting universal tumor antigensAlbert DonnenbergReconciling vaccines with dose-intensive therapy
McArthur Ballroom Salons 1 and 2
simultaneous plenary session bTumor Evaluation/MRDCo-Chairs: Graham Sharp and Klaus PantelJohn ParkComparative analysis of immunocytochemistry (ICC),automated ICC, flow cytometry and RT-PCR in breastcancer patientsMichael SpeicherAdvanced cytogenetic analysis of metastatic tumor cellsGunnar KvalheimLatest clinical data on the Norwegian breast cancermicrometastases studyGraham SharpClinical significance of non-Hodgkin’s lymphoma MRD McArthur Ballroom Salon 4
Cytotherapy Editorial Board MeetingGrand Canyon
Education Committee MeetingKaibab
break and exhibitsFrank Lloyd Wright Ballroom
3:15 pm – 3:40 pm
3:40 pm –4:40 pm
oral abstractpresentationsEx Vivo ExpansionChairs: Elizabeth Shpall andJohn McMannisMcArthur Ballroom Salon 1
oral abstractpresentationsTumor Evaluation/MRD
McArthur Ballroom Salon 2
oral abstractpresentationsRegulatory/Process ControlChair: Linda Kelley
isct executive committee and advisory board meetingGrand Canyon
8:30 pm – 10:30 pm
page 14
day four saturday may 31
7:00 am –8:00 am
8:00 am –9:20 am
plenary session iiGene Therapy & Hematopoietic Stem Cell TransplantationChair: Helen HeslopMalcolm Brenner How gene transfer may contribute to cellular therapiesBrenda Sandmaier The future of allogeneic hematopoietic stem cell transplantationMcArthur Ballroom Salon 4break and exhibitsFrank Lloyd Wright Ballroom
Ex Vivo ExpansionCommitteeMeeting/Cord BloodCommittee Meeting
Cameron
Legal and RegulatoryAffairs CommitteeMeeting
Prescott
TechnologistsCommittee Meeting
Rimrock
break and exhibitsFrank Lloyd Wright Ballroom
3:05 pm –3:30 pm
3:30 pm –4:30 pm
educational session 7Graft Evaluation
Katarina Le Blanc and Hans Johnsen
McArthur Ballroom Salon 1
educational session 8Cord Blood/Ex Vivo Expansion
Ian McNiece, David Haylock, JoanneKurtzberg and John McMannisMcArthur Ballroom Salon 2
how to prepare a clinical ind
Linda Kelley, Bambi Grilley, Helen Heslop,John McMannis and Elizabeth ReadMcArthur Ballroom Salon 3
4:35 pm –5:35 pm
workshop 7Graft Evaluation
Robert Sutherland and Stephen Noga
McArthur Ballroom Salon 1
workshop 8Cord Blood/Ex Vivo Expansion
Ian McNiece, David Haylock,Joanne Kurtzberg and John McMannisMcArthur Ballroom Salon 2
cryopreservationcontainer q&a
Chair: Lee Buckler
McArthur Ballroom Salon 3
isct 2003 bbqGrand Ballroom and Squaw Peak Terrace
7:30 pm
page 15
5:40 pm –6:40 pm
oral abstract presentationsGraft EvaluationChairs: John Jackson andKevin SheehanMcArthur Ballroom Salon 1
oral abstract presentations Gene Therapy
McArthur Ballroom Salon 2
oral abstract presentationsNon-Hematopoietic and MesenchymalStem CellsChair: Ineke Slaper-CortenbachMcArthur Ballroom Salon 3
simultaneous plenary session cGene TherapyCo-Chairs:Scott Burger & Isabelle RiviereMichel SadelainTranslating lentiviral vectors to the clinicClaudio BordignonGene therapy of immunodeficiency using subablativeconditioning regimensKim LyerleyClinical studies using RNA transfer into dendritic cellsMike JensenGenetic modification of T cells
McArthur Ballroom Salons 1 and 2
simultaneous plenary session dHematopoietic Stem Cell TransplantationCo-Chairs: Donna Przepiorka & Rupert HandgretingerCrystal MackallPotential role of Interleukin 7 in allogeneic transplantationVanderson RochaAllogeneic stem cell transplantation using cord bloodstem cellsRichard ChamplinMinitransplantationYair ReisnerCrossing HLA barriers by megadose stem cell transplants:immune regulation by early hematopoietic progenitorsMcArthur Ballroom Salon 4
day five sunday june 1
7:00 am –8:00 am
page 16
program
TB 13CD 34 Selection
Shelly HeimfeldMcArthur BallroomSalon 5
TB 14Dendritic CellPreparation
Charley Carter
Sedona
TB 15Characterization ofT Cell Products forImmunotherapy
plenary session iiiNon-Hematopoietic Stem Cells & Evaluating Grafts for Long-Term OutcomesChair: Robert NegrinEdwin HorwitzMesenchymal stem cell therapy: the new frontierAndrew PecoraReplication competent viruses as adjuncts to cell based immunotherapyMcArthur Ballroom Salon 4
break9:20 am –9:45 am
9:45 am –12:00 noon
simultaneous plenary session e Non-Hematopoietic Stem CellsChair: Edwin Horwitz Mark PittengerMesenchymal stem cells as progenitors of cardiacmyocytesJonathon HillMesenchymal stem cell therapy for cardiovasculardisease: preparing for clinical trialsPeter WernetMyocardial regeneration with autologous bone marrowderived progenitor cells following infarction in menDonald OrlicStem cells for myocardial regeneration: mouse andmonkey models
McArthur Ballroom Salons 1 and 2
simultaneous plenary session fEvaluating Grafts for Long-Term OutcomesChair: Robert Negrin Carolyn Keever-TaylorEstablishment of treatment algorithm for recipientsof alternative donor grafts for the treatment ofhematologic malignanciesFrancesco LanzaWhich phenotypic subsets may predict transplantationpatient outcome?Hans E. JohnsenClinical registration studies on quality assessment ofautograftingShelly HeimfeldAssociations of CD34 cell dose with clinical outcomesin HLA-identical transplantationMcArthur Ballroom Salon 4
