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Research Articles: Systems/Circuits
Impact of altered cholinergic tones on the neurovascular coupling response towhisker stimulation
Clotilde Lecrux1,2, Claire H. Sandoe1, Sujaya Neupane2, Pascal Kropf2, Xavier Toussay1, Xin-Kang Tong1, María
Lacalle-Aurioles1, Amir Shmuel2 and Edith Hamel1
1Laboratory of Cerebrovascular Research2Laboratory of Brain Imaging Signals, Montreal Neurological Institute, McGill University, Montréal, QC, Canada
DOI: 10.1523/JNEUROSCI.1784-16.2016
Received: 25 May 2016
Revised: 22 December 2016
Accepted: 30 December 2016
Published: 9 January 2017
Author contributions: C.L., C.S., A.S., and E.H. designed research; C.L., C.S., P.K., X. Toussay, and X. Tongperformed research; C.L., C.S., S.N., P.K., X. Toussay, X. Tong, and M.L.-A. analyzed data; C.L., C.S., S.N.,M.L.-A., A.S., and E.H. wrote the paper; S.N. and M.L.-A. contributed unpublished reagents/analytic tools.
Conflict of Interest: None declared.
Funding: Supported by grants from the Canadian Institute of Health Research (CIHR, MOP-84209 andMOP-142417, EH; MOP-102599, AS), the Heart & Stroke Foundation of Canada (EH), the Human FrontierScience Program (RGY0080/2008, AS), a Jeanne Timmins Costello Postdoctoral Fellowship (CL), and a JeanneTimmins Costello studentship (CHS).
Corresponding author: Dr. Clotilde Lecrux, Laboratory of Cerebrovascular Research, Montreal NeurologicalInstitute, 3801 University Street, Montréal, QC, Canada H3A 2B4, E-mail: [email protected], Tel: (+1)514 398 8931
Cite as: J. Neurosci 2017; 10.1523/JNEUROSCI.1784-16.2016
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Electrophysiology
Whisker stimulation
Identification of the neuronal network recruited by whisker stimulation
LFP/CBF correlations:
Cholinergic denervation:
C-Fos immunostaining in the barrel cortex:
Identification of c-Fos-immunopositive neurons in the activated barrel cortex:
Statistical Analysis: