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Importance of Treating Iron Deficiency Anaemia
in Pregnancy
Iron Deficiency Anaemia
Iron Deficiency Anaemia Is the Most Prevalent Micronutrient Deficiency Affecting Just Over
2 BILLION
People Of the World.
WHO Mortality Data
Around
0.8 MILLION
Deaths Are Attributed to
Iron Deficiency Each Year
WHO Mortality Data
In Terms of the Loss of Healthy Life Years (Dalys), IDA Results
in 25 MILLION
Dalys Lost Each Year.
DALYs = Disability Adjusted Life Years The sum of years of potential life lost due to premature mortality and the years of productive life lost due to disability.
Economic Cost
The Economic Cost of Iron Deficiency Is Huge Because It Decreases the
PRODUCTIVITY
And COGNITIVE
Function
Economic Loss
Annual Economic Loss Due to IDA in Four Countries of South Asia Namely Bangladesh, India, Pakistan and Sri Lanka Is
$4.2 BillionWith a loss of almost 0.6 % of
its GDP due to IDA
Prevalence
“Almost
One Out of Two
Women of Child Bearing
Age Suffer From Anemia”
National Institute Of Population StudiesNational Institute Of Population Studies
Risk
629 Pregnant Women Were Studied
• 313 Were (Hb <11 G/dl) Anaemic Group
• 316 Were (Hb >11 G/dl) Non-anaemic Group
For Anaemic Women
Preterm Delivery Was 4 Times Higher
LBW was 1.9 Times Higher
Risk of IUD Was 3.7 Times Higher
Tropical Medicine and International Health vol9(4) 486–490 apr 04 Aga Khan University, Karachi, Pakistan
Folate Deficiency
Folate Deficiency Causes
Neural Tube Defect (NTD)
to the Baby If the Pregnant Mother Has Low Folic Acid Status at the
TIME OF CONCEPTION
Developing Countries
In Many Developing Countries the Women Even Do Not Know That She Is Having a Baby.
CDC Scientists Have Estimated That Every Year
500,000 Severe Birth Defects
Are Caused by Folic Acid Deficiency.
Folic Acid In NTD
0%
23%36%
52%57%
82% 85%
0%
15%
30%
45%
60%
75%
90%
0 mg 0.2 mg 0.4 mg 0.8 mg 1 mg 4 mg 5 mg
Increase in Daily Folic Acid Intake
Perc
en
tag
e o
f N
TD
s Th
at
Wou
ld B
e P
reven
ted
Ironur-IPS
Is a compound containing
Iron Protein Succinylate
+ Folic Acid
developed by Biocon.
Is a compound containing
Iron Protein Succinylate
+ Folic Acid
developed by Biocon.
Ironur-IPS
Each 15 ml contains
Iron Protein Succinylate ………… 800 mg
Folic Acid ………………………………...5
mg
Iron Content
Each 1 ml contain: 2.67 mg iron *
Each 5 ml contains: 13.33 mg iron *
Each 7.5 ml contain: 20 mg iron *
Each 10 ml contains: 26.67 mg iron *
Each 15 ml contain: 40 mg iron *
*elemental iron
Description
Ironur IPS (Iron Protein Succinylate) Is an Iron Compound Specially Bonded to Chemically Modified Protein Casein (Milk Protein) in a Process Called Succinylation, Which Dramatically Stabilizes the Complex
Description
Efficacy
BJOG. 2002 Sep;109(9):1009-14.
Increase in Haemoglobin in Severe Anaemia in Pregnancy
2.3g/dl
0.5g/dl
0
0.5
1
1.5
2
2.5
1 2
Iron Protein Succinylate + Folate
Iron Protein Succinylate
Hae
mog
lobi
n C
once
ntra
tion
g/dl
P = 0.07
Efficacy
BJOG. 2002 Sep;109(9):1009-14.
1.42g/dl
0.8g/dl
0
0.5
1
1.5
2
1 2
Iron Protein Succinylate + Folate
Iron Protein Succinylate
Hae
mog
lobi
n C
once
ntra
tion
g/dl
P < 0.001
Increase in Haemoglobin in Overall Population of Pregnant Women
Ironur IPS Vs IPC
Ironur-ips Led Not Only to a
FASTER INCREASE
of Hemoglobin, Hematocrit, MCV, Serum Iron, and Ferritin Than Iron Hydroxide Polymaltose Complex, but the Laboratory Values Remained Higher in Group A (Ironur-IPS) Than in B (Iron Hydroxide Polymaltose Complex) even After 2 Months of Treatment.
Int J Clin Pharmacol Ther. 1998 Jun;36(6):320-5.
Safety Profile
• Excellent Safety Profile in 93% Patients
Adverse Events
7%
Gastric Tolerability
93%
Additional Benefits
Ironur-IPS
• Additional Folic Acid is present for
additional benefits
• Free From
Sodium & Potassium and Sugar
Who Needs Ironur IPS
Where demands of iron is increased
– Women, especially those with the history of child bearing challenges
– People with diets that are low in both meat and ascorbic acid
– Elderly
– Who donate blood more than 3 times a year
– Growing children
Why Ironur IPS
• Unsurpassed Efficacy
• Excellent gastric tolerability
• Improved Absorption
• Additional benefits of Folic Acid
• Superior Safety Profile
Doses
Adults: 15 – 30 ml /day
Children: 1.5 ml/Kg/day in 2divided doses