In the name of
God
Summer School
Influenza Unit,Pasteur Institute of Iran
summer 2011
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Dr.V.MAZAHERI
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
The use of amantadine is associated with the rapid emergence of drug-resistant variants. Resistant isolate of influenza A are genetically stable and fully transmissible, and the pathogenic potential is comparable to that of wild-type virus isolates. In immunocompromised patients, resistant virus can be shed for prolonged periods(Boivin 2002). According to a study which assessed more than 7,000 influenza A virus samples obtained from 1994 to 2005, drug resistance against amantadine and rimantadine has increased worldwide from 0.4 % to 12.3 % (Bright 2005).
References1. Bean WJ, Threlkeld SC, Webster RG. Biologic potential of amantadine-resistant influenzaA virus in an avian model. J Infect Dis 1989; 159: 1050-6. 2. Boivin G, Goyette N, Bernatchez H. Prolonged excretion of amantadine-resistant influenzaa virus quasi species after cessation of antiviral therapy in an immunocompromisedpatient. Clin Infect Dis 2002; 34
3. Bright RA, Medina MJ, Xu X, et al. Incidence of adamantane resistance among influenzaA (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet2005; 366: 1175-81. Epub 2005 Sep 22.
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
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Influenza Unit, Pasteur Institute of Iran summer 2011
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