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In the name of God

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In the name of God. Summer School. Influenza Unit, Pasteur Institute of Iran summer 2011. EndNote. Dr.V.MAZAHERI. EndNote-complete reference solution!. An online search tool A reference and figure database Store, manage and search Organize figures - PowerPoint PPT Presentation
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In the name of God
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Page 1: In the name of  God

In the name of

God

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Summer School

Influenza Unit,Pasteur Institute of Iran

summer 2011

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EndNote

Dr.V.MAZAHERI

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Influenza Unit, Pasteur Institute of Iran summer 2011

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Influenza Unit, Pasteur Institute of Iran summer 2011

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The use of amantadine is associated with the rapid emergence of drug-resistant variants. Resistant isolate of influenza A are genetically stable and fully transmissible, and the pathogenic potential is comparable to that of wild-type virus isolates. In immunocompromised patients, resistant virus can be shed for prolonged periods(Boivin 2002). According to a study which assessed more than 7,000 influenza A virus samples obtained from 1994 to 2005, drug resistance against amantadine and rimantadine has increased worldwide from 0.4 % to 12.3 % (Bright 2005).

References1. Bean WJ, Threlkeld SC, Webster RG. Biologic potential of amantadine-resistant influenzaA virus in an avian model. J Infect Dis 1989; 159: 1050-6. 2. Boivin G, Goyette N, Bernatchez H. Prolonged excretion of amantadine-resistant influenzaa virus quasi species after cessation of antiviral therapy in an immunocompromisedpatient. Clin Infect Dis 2002; 34

3. Bright RA, Medina MJ, Xu X, et al. Incidence of adamantane resistance among influenzaA (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet2005; 366: 1175-81. Epub 2005 Sep 22.

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Introduction to an EndNote Library

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Influenza Unit, Pasteur Institute of Iran summer 2011

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Thanks


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