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Incomplete Dominance Co-dominance

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Incomplete Dominance Co-dominance. Extending Mendelian genetics. Mendel worked with a simple system peas are genetically simple most traits are controlled by a single gene each gene has only 2 alleles, 1 of which is completely dominant to the other - PowerPoint PPT Presentation
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Bi 2g, 3a Incomplete Dominance Co-dominance
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Page 1: Incomplete Dominance Co-dominance

Bi 2g, 3a

Incomplete DominanceCo-dominance

Page 2: Incomplete Dominance Co-dominance

Extending Mendelian genetics

Mendel worked with a simple system peas are genetically simple most traits are controlled by a single

gene each gene has only 2 alleles, 1 of which

is completely dominant to the other The relationship between

genotype & phenotype is rarely that simple

Page 3: Incomplete Dominance Co-dominance

Incomplete dominance Heterozygote shows an

intermediate, blended phenotype example:

▪ RR = red flowers▪ rr = white flowers▪ Rr = pink flowers

▪ make 50% less color

RR

RRWWRW

WWRW

Page 4: Incomplete Dominance Co-dominance

Incomplete dominancetrue-breeding

red flowerstrue-breeding white flowers

XP

100%

100% pink flowersF1

generation(hybrids)

self-pollinate

25%whit

eF2generation

25%

red1:2:

1

50%pink

It’s likeflipping 2 pennies!

Page 5: Incomplete Dominance Co-dominance

Co-dominance 2 alleles affect the phenotype

equally & separately not blended phenotype human ABO blood groups 3 alleles

▪ IA, IB, i▪ IA & IB alleles are co-dominant

▪ glycoprotein antigens on RBC▪ IAIB = both antigens are produced

▪ i allele recessive to both

Page 6: Incomplete Dominance Co-dominance

Genetics of Blood type

pheno-type

genotypeantigenon RBC

antibodiesin blood

donationstatus

A IA IA or IA itype A antigens

on surface of RBC

anti-B antibodies __

B IB IB or IB itype B antigens

on surface of RBC

anti-A antibodies __

AB IA IBboth type A &

type B antigens on surface

of RBC

no antibodies universal recipient

O i ino antigens on surface

of RBC

anti-A & anti-B antibodies

universal donor

Page 7: Incomplete Dominance Co-dominance

Sex-linked InheritanceBi-2g, 3a

Page 8: Incomplete Dominance Co-dominance

Sex linked traits Genes are on sex chromosomes

as opposed to autosomal chromosomes first discovered by T.H. Morgan at Columbia U. Drosophila breeding

▪ good genetic subject▪ prolific

▪ 2 week generations

▪ 4 pairs of chromosomes

▪ XX=female, XY=male

1910 | 1933

Page 9: Incomplete Dominance Co-dominance

Huh!Sex matters?!

F2generation

100%red-eye female

50% red-eye male50% white eye male

Discovery of sex linkage

P X

F1generation(hybrids)

100%red eye

offspring

true-breeding white-eye male

true-breedingred-eye female

Page 10: Incomplete Dominance Co-dominance

Genetics of Sex In humans & other mammals, there are

2 sex chromosomes: X & Y 2 X chromosomes

▪ develop as a female: XX

▪ gene redundancy,like autosomal chromosomes

an X & Y chromosome▪ develop as a male: XY▪ no redundancy

X Y

X

X

XX

XY

XY

50% female : 50% male

XX

Page 11: Incomplete Dominance Co-dominance

XRXR XrY

Sex-linked inheritance

x

Xr Y

XR

100% red eyes

XR

XRXr XRY

XRYXRXr

x

XRXr XRY

XR Y

XR

Xr

XRXr

XRYXRXR

XrY100% red females50% red males; 50% white males

BINGO!

Page 12: Incomplete Dominance Co-dominance

Human X chromosome Sex-linked

usually means“X-linked”

more than 60 diseases traced to genes on X chromosome

Duchenne muscular dystrophyBecker muscular dystrophy

Ichthyosis, X-linkedPlacental steroid sulfatase deficiencyKallmann syndromeChondrodysplasia punctata, X-linked recessiveHypophosphatemiaAicardi syndromeHypomagnesemia, X-linkedOcular albinismRetinoschisisAdrenal hypoplasiaGlycerol kinase deficiency

Incontinentia pigmentiWiskott-Aldrich syndromeMenkes syndrome

Charcot-Marie-Tooth neuropathyChoroideremiaCleft palate, X-linkedSpastic paraplegia, X-linked, uncomplicatedDeafness with stapes fixationPRPS-related gout

Lowe syndrome

Lesch-Nyhan syndromeHPRT-related goutHunter syndromeHemophilia BHemophilia AG6PD deficiency: favismDrug-sensitive anemiaChronic hemolytic anemiaManic-depressive illness, X-linkedColorblindness, (several forms)Dyskeratosis congenitaTKCR syndromeAdrenoleukodystrophyAdrenomyeloneuropathyEmery-Dreifuss muscular dystrophyDiabetes insipidus, renalMyotubular myopathy, X-linked

Androgen insensitivity

Chronic granulomatous diseaseRetinitis pigmentosa-3

Norrie diseaseRetinitis pigmentosa-2

Sideroblastic anemiaAarskog-Scott syndrome

PGK deficiency hemolytic anemia

Anhidrotic ectodermal dysplasia

AgammaglobulinemiaKennedy disease

Pelizaeus-Merzbacher diseaseAlport syndrome

Fabry disease

Albinism-deafness syndrome

Fragile-X syndrome

Immunodeficiency, X-linked,with hyper IgM

Lymphoproliferative syndrome

Ornithine transcarbamylase deficiency

Page 13: Incomplete Dominance Co-dominance
Page 14: Incomplete Dominance Co-dominance

Hemophilia

Hemophilia is a sex-linked recessive trait defined by the absence of one or more clotting factors. These proteins normally slow and then stop bleeding.

Individuals with hemophilia have prolonged bleeding because a firm clot forms slowly. Bleeding in muscles and joints can be painful and lead to serious damage.

Individuals can be treated with intravenous injections of the missing protein.

Page 15: Incomplete Dominance Co-dominance

Hemophilia

Hh x HHXHYXHXh

XHXh

XH

Xh

XHY

Y

XH

sex-linked recessive

XH Ymale / sperm

XH

Xh

fem

ale

/ eg

gs XHXH

XHXh

XHY

XhY

XHXH XHY

XHXh XhY

carrier disease

Page 16: Incomplete Dominance Co-dominance

X-inactivation Female mammals inherit 2 X

chromosomes one X becomes inactivated during

embryonic development▪ condenses into compact object = Barr body▪ which X becomes Barr body is random

▪ patchwork trait = “mosaic”

XH

Xh

XHXh

patches of black

patches of orange

tricolor catscan only befemale

Page 17: Incomplete Dominance Co-dominance

Male pattern baldness Sex influenced trait

autosomal trait influenced by sex hormones▪ age effect as well = onset after 30 years old

dominant in males & recessive in females▪ B_ = bald in males; bb = bald in females


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