INDEX

Volume 21 9, October-December, 1981

Abuchowski, A., Karp, D. and

Davis, F. F.: Reduction of

plasma urate levels in thecockerel with polyethyleneglycol-uricase, 352

Acetaminophenand its metabolites, tissue levels

after toxic dose (mice), 281elimination, nonlinear kinetics

(rats), 14

internal standard for calibrat-

ing in vivo electrochemical

electrodes in brain (rats), 49metabolism, prostaglandin en-

doperoxide synthetase renal

cooxidation of (rabbits), 659sn-2-Acetylated choline phospho-

lipids, hypotensive effect(rats), 219

Acetylcholinebrain, turnover rate, effect of

pentobarbital (rats), 489effect on response and sensitiv-

ity of lung parenchymalstrips (guinea pigs), 1

release, involvement in inhibi-tory effect of morphine atcholedochoduodenal junc-tion (dogs), 274

N-Acetylcysteine, effect on acet-

aminophen elimination ki-netics (rats), 14

N-Acetyltransferase rhythm, pin-eal, effect of lithium (rats),121

Acyclovir, disposition (mice, rats,dogs, monkeys), 309

Adenosinereceptors, evidence against

presence in nictitating mem-brane (cats), 235

regulation of cyclic AMP for-mation in spinal cord (rats),370

Na, K-Adenosine triphosphatase

inhibition by HgCl2 (fish), 428

smooth muscle vas deferens,binding of [3Hlouabain to(guinea pigs), 163

Na�, K�-Adenosine triphospha-

tase, troleandomycin induc-

tion (rats), 558

Adenylate cyclaseactivity in atria, effect of die-

tary lipid on (rats), 625myocardial and soleus, effects

of isoproterenol, prenalterol

and procaterol (cats), 798Adrenergic blockade, beta, with

propranolol, dosage require-ments and effects on heartrate and left ventricular per-formance (calves), 394

Adrenergic receptors (see also

Adrenoceptors)

alpha, in spinal cord, interac-tion with adenosine (rats),370

alpha, -mediated renin releaseis prostaglandin-dependent(dogs), 321

alpha and beta, activities of

stereoisomers of dobutamine(rats, cats), 447

alpha-i and alpha-2, in uterus,mediation of myometrial con-traction and regulation by es-trogen (rabbits), 290

beta, myocardial, action of thy-roid hormones (calves), 394

pineal beta, effect of lithium(rats), 121

renal alpha-i and alpha-2, bio-chemical and pharmacologi-cal correlations (rats), 400

Adrenoceptors (see also Adrener-gic receptors)

alpha-2, prejunctional functionin vas deferens after gangli-onic blockade (guinea pigs,

rats), 21

alpha and beta interconver-

sion, effects of carbachol andhypothyroidism (rats), 231

apha-1 and alpha-2, pre- andpostsynaptic, selectivity

studies with yohimbine, rau-

wolscine and corynanthine(dog), 540

beta, interaction of full and par-

tial agonists in heart and so-leus muscle (cats), 798

Adrenoceptor agonists, selectivity

for peripheral alpha-i andalpha-2 adrenoceptors (rats),760

Adrenochrome-induced coronary

artery constriction in heart(rats), 225

Agonist uptake effects, selectiveinhibition of (rats, guineapigs), 112

Aiken, J. W., Shebuski, R. J.,Miller, 0. V. and Gorman, R.R.: Endogenous prostacyclincontributes to the efficacy ofa thromboxane synthetaseinhibitor for preventing cor-onary artery thrombosis, 299

f.�-Alanine, inhibitory effects on

cerebral cortical and Pur-kinje neurons (rats), 604

Albuquerque, E. X., see Maleque,M. A., 638

Aldehyde dehydrogenase, liver,inhibition by carbon tetra-chloride (rats), 821

Alkadhi, K. A., see Volle, R. L.,

338

Almeida, A. P., see Bayer, B. M.,752

Amilorideinhibition and stimulation of

sodium transport in skin(toads), 481

renal tubule transport and elec-trolyte effects (chickens�, 435

Amino acid uptake, effect of’anti-

inflammatory drugs (rats),

752p-Aminohippurate, transport in

renal tissue, heavy metal in-hibition (fish), 428

6-Aminomethyl-3-methyl-4H- 1,

2,4-benzothiadiazine - 1,1-

dioxide hydrochloride, tau-

rime antagonist, neurophar-macological characterization(rats), 604

4-Aminopyndineeffects on adrenergic nerve ter-

minals in thoracic aorta andpulmonary arteries (rabbits),792

effect on cyclic GMP accumu-lation in ganglion (rats), 338

effects on nerve terminal actionpotentials (frogs), 268

Amitriptylene, inhibitor of ago-inst uptake effects (rats,guinea pigs), 112

Amphetamine, effect on releaseof catecholamines in brain(rats), 49

d-Amphetaminebehavioral effects (monkeys),

199

behavioral effects, comparisonwith I- and dl-cathinone(monkeys), 355

Analgesiamorphine- and f3-endorphin-in-

duced, possible regulatoryrole of dynorphin on (mice),296

nantradol hydrochloride (mice,rats, dogs), 363

SKF 10,047 and morphine, ef-fect of naloxone (rats, mice),192

Anesthesia, pentobarbital, role ofseptal-hippocampal cholin-ergic pathway in antagonismof (rats), 489

Angiotensin IIblockade, role in renal vasodi-

lator effect of captopril(dogs), 646

-elicited renal vasoconstrictorresponse, effect of arachi-donic acid on (dogs), 377

role in furosemide-induced de-

crease in mesenteric blood

flow (dogs), 407Angiotensin converting enzyme,

inhibition by captopril

(dogs), 646

Angus, J. A., see Kenakin, T. P.,474

Antagonist, taurine, neurophar-macological characterization(rats), 604

Antidiuretic hormonefluoride inhibition of hydro-os-

motic response of urinarybladder to (toads), 459

role in furosemide-induced de-crease in mesenteric bloodflow (dogs), 407

Antimycin, effect on strophanthi-din-induced arrhythmias and

contracture in cardiac Pur-

kinje fibers (dogs), 75Aorta, alpha and beta adrenergic

activities of dobut.amine ster-

eoisomers (rats, cats), 447Apomorphine

effect on conditioned taste

aversion and schedule-con-

trolled behavior (rats), 60effect on stimulation-evoked

release of [‘H]dopamine in

retina (rabbits), 701-induced stereotypic behavior

(mice), 695Arachidonic acid, actions on renal

vascular reactivity (dogs),377

Arrhythmias, strophanthidin-in-

duced in cardiac Purkinje fi-bers, effect of metabolic in-hibitors (dogs), 75

Arteries

and veins, pulmonary, sensi-tired, pharmacological stud-ies (dogs), 551

coronary, large and small, dilat-ing effects of trapidil, nitro-glycerin and dipyridamole(dogs), 809

pulmonary and thoracic aorta,effects of 4-aminopyridine onadrenergic nerve terminals of(rabbits), 792

pulmonary, intralobar, effectof prostacyclin and 9a, 1 la-

epoxymethanoprostaglandinH2 on calcium and magne-sium flux�ms and tension de-

velopment in (dogs), 326Artery

cardiac smooth muscle, effect ofmethylene blue and methe-moglobin on relationship be-tween cyclic GMP formationand relaxation of (cows), 181

829

830 Index Vol. 219

coronary, adrenochrome-in-duced constriction in heart(rats), 225

coronary, thrombosis, platelet-dependent, contribution ofprostacyclin to preventive ef-fect of thromboxane synthe-tase inhibitor (dogs), 299

mesenteric, circulation, differ-ential effects ofibuprofen andindomethacin (dogs), 679

Arthritis, adjuvant, effect of ox-onate-induced hyperuricemiaon (rats), 73i

Aspirin, comparative effect on en-dothelial and platelet prosta-glandin synthesis (man), 415

Asthma, allergic, effects of hista-

mine, norepinephrine andserotonin (dogs), 551

Atrium, alpha and beta adrener-gic activities of dobutaminestereoisomers (rats, cats), 447

Atropine, stimulatory effect onmorphine at choledochoduo-denal junction by (dogs), 274

Autonomic innervation, of tin-

nary bladder, development of(rabbits), 250

Axelson, J. E., see Tam, Y. K., i4i

Azepexole, continuous infusion

and sudden withdrawal, in-fluence on blood pressure andheart rate (rats), 786

Bacopoulos, N. G.: Antipsychoticdrug effects on dopamine andserotonin receptors: In vitrobinding and in vivo turnoverstudies, 708

Bagwell, E. E., see Cordova, M.A., 187

Bandura, J. P., see Iansmith, D.H. S., 651

Barium chloride, effect on re-sponse and sensitivity of lungparenchymal strips (guinea

pigs), 1Barker, L. A., see Hough, L. B.,

453

Barrett, J. E., Valentine, J. 0. andKatz, J. L.: Effects of chlor-diazepoxide and d-amphet-

amine On responding of squir-

rel monkeys maintained un-der concurrent or second-or-der schedules of response-produced food or electricshock presentation, 199

Bayer, B. M., Almeida, A. P. andBeaven, M. A.: Inhibition ofthe expression of the “A” sys-tem of amino acid transportby anti-inflammatory drugs

during cell culture growth

and mitogenic stimulation ofthymus lymphocytes, 752

Beamish, R. E., see Karmazyn,M., 225

Beaven, M. A., see Bayer, B. M.,752

Beckett, W., see Feigen, L. P., 679Beek, D., see Kenakin, T. P., 112Beer, D. G., see Hjelle, J. J., 821

Behaviorconditioned taste aversion and

operant, effects of cocaine,apomorphine, diisobutyryl-

apomorphine and Win 35,428(rats), 60

effects of indolealkylamine andphenethylamine hallucino-gens, antagonism by meter-

goline (rats), 170

effects of nantradol hydrochlo-

ride (mice, rats, dogs), 363schedule-controlled and oper-

ate, effects of chlordiazepox-ide and d-amphetamine on(monkeys), 199

schedule-controlled drug-main-tamed responding, compari-son of I- and dl-cathinoneand d-amphetamine (mon-keys), 355

schedule-controlled, effects ofmorphine and enkephalins(rats), 344

stereotypic, apomorphine-in-

duced (mice), 695

use of tail-flick method to mea-sure morphine- and $-endor-phin analgesia (mice), 296

Bellville, J. W., see Kaufman, R.D., 156

Bend, J. R., see Elmamlouk, T.H., 27

Bend, J. R., see Steele, J. W., 35Benos, D. J. and Watthey, J. W.

H.: Inferences on the natureof the apical sodium entry

site in frog skin epithelium,

481

Besseghir, K. and Rennick, B.:Renal tubule transport andelectrolyte effects of amior-ide in the chicken, 435

Bethanechol, effect on cyclicGMP accumulation in gan-glion (rats), 338

B-HT 920, selectivity for periph-

eral alpha-i and alpha-2 ad-renoceptors (rats), 760

B-HT 933, selectivity for periph-eral alpha-i and alpha-2 ad-renoceptors (rats), 760

Bhattacharyya, M. L. and Vas-salle, M.: The effect of mets-bolic inhibitors on strophan-thidin-induced arrhythmias

and contracture in cardiacPurkinje fibers, 75

Bianchi, R. G., see Gullikson, E.z., 591

Bicarbonate, reabsorption inrenal tubule, effect of etha-crynic acid (dogs), 505

Bicucullineeffect on metabolism of acetyl-

choline (rats), 489effect on taurine-induced hy-

pothermia (rabbits), 778Bile

excretion of [2,4)4C]dinitro-toluene in isolated perfusedliver (rats), 598

excretion of retinamide (rats),632

secretion, effect of troleando-mycin (rats), 558

Bile salt synthesis, troleandomy-cin inhibition (rats), 558

Biotransformation, of acyclovir(mice, rats, dogs, monkeys),309

Benzimidazole, effect on sodium

transport in skin (toads), 481

Bladdermicrosomal nitroreductase ac-

tivity (rabbits), 735

urinary, development of auto-nomic innervation and con-tractile response of (rabbits),250

urinary, hydro-osmotic re-sponse to antidiuretic hor-

mone, fluoride inhibition(toads), 459

Blanford, M., see Lima, J. J., 741Bleomycin-induced pulmonary fi-

brosis, increased lysyl oxidaseactivity in lung during (rats),

675

Bloch, R., see Bousquet, P., 213Blood flow

mesentenc, role of volume de-pletion, antidiuretic hormoneand angiotensin II in furose-mide-induced decrease in(dogs), 407

renal, effect of captopril (dogs),646

renal, effects of ibuprofen andindomethacin (dogs), 679

Blood pressureaortic, effects of ibuprofen and

indomethacin (dogs), 679effect of azepoxole (rats), 786effects of taurine, homotaurine

and muscimol (cats), 213Blood vessels, pulmonary, sensi-

tized, pharmacological stud-

ies (dogs), 551

Bluestone, R., see Chang, Y.-H.,731

Bond, J. A., Medinsky, M. A.,Dent, J. G. and Rickert, D.E.: Sex-dependent metabo-lism and biliary excretion of[2,4-’4C}dinitrotoluene inisolated perfused rat livers,598

Boudoulas, H., see Lima, J. J., 741

Bousquet, P., Feldman, J., Bloch,R. and Schwartz, J.: Centralcardiovascular effects of tau-

line: Comparison with ho-motaurine and muscimol, 213

Boyd, J. A. and Eling, T. E.: Pros-taglandin endoperoxide syn-thetase-dependent cooxida-tion of acetaminophen to in-termediates which covalentlybind in vitro to rabbit renalmedullary microsomes, 659

Brady, L. S. and Holtzman, S. G.:Effects of intraventricular

morphine and enkephalins onschedule-controlled behaviorin nondependent, morphine-

dependent and postdepen-dent rats, 344

Bradycardia, effects of N,N-di-n-propyl-dopamine (rats, dogs),

510Brain

N-acetyltransferase rhythm, ef-fect of lithium (rats), 121

effects of haloperidol and buta-

clamol on [3H]spiroperidol

binding and dopamine andserotonin turnover in (rats),708

effect of heparin or salicylate

acid on phenytoin in (rats),

42

electrochemical electrodes, cal-

ibration by acetaminophen

(rats), 49

histamine H2-receptors, antag-

onism by propantheline and

derivatives (guinea pigs), 453interaction between impulse-

flow and A9-tetrahydrocan-

nabinol within septal-hippo-

campal cholinergic pathway

of (rats), 580

mesencephalic reticular forma-tion, effects of cyclic AMP,morphine and methiomne-enkephalin on neuronal firing

in (rats), 496

Purkinje neurons, electrophys-iological response to leuko-triene D4 and B4 (guinea pigs,rats), 91

serotonin, role in maintenanceof plasma renin activity(rats), 85

serotonin system and taurine-induced hypothermia (rab-bits),778

Breast milk levels, effect of val-proic acid (man), 768

Bretylium, inhibition of release ofnorepinephrine in spleen(cats), 748

Brink, C., Duncan, P. G. andDouglas, J. S.: The lung pa-renchymal strip: A reap-praisal, 1

Bromobenzene, epoxidation lead-ing to binding on macromo-lecular protein sites (rats),563

Bromocriptine, effect on aging

and regulation of striatal

dopaminergic mechanisms(mice), 695

2-Bromooctanoate, effect on p-ni-troanisole 0-demethylationin isolated perfused liver(rats), 383

Brunello, N. and Cheney, D. L.:The septal-hippocampal cho-linergic pathway: Role in an-tagonism ofpentobarbital an-

esthesia and regulation by

various afferents, 489

Burley, E. S. and Jacobs, R. S.:Effects of4-aminopyridine onnerve terminal action poten-tials, 268

Butaclamol, effect on [3H]spiro-peridol binding and dopa-mine and serotonin turnoverin brain (rats), 708

45Ca, uptake and cyclic GMP ac-cumulation in ganglion, effectof preganglionic nerve stun-

ulation (rats), 338

Ca�tdependent action potentialsin potassium-depolarized ac-

1981 Index 831

tion potentials, effects of pa-paverine (guinea pig), 715

Ca�� release, from sarcoplasmicreticulum, prilocaine-induced

(frogs), 815Cadmium, inhibition of p-amino-

hippurate transport in renaltissue (fish), 428

Calciumfluxes, in intralobar pulmonary

arteries and veins, effect ofprostacyclin and 9a,lla-epoxymethanoprostaglandinH2 on (dogs), 326

-mediated phosphodiesteraseactivity, relationship to hy-dro-osmotic actions of anti-diuretic hormone, effects offluoride (toads), 459

metabolism, role in responsesof malignant hyperthermia

(pigs), 107

Calcium channels, in skeletalmuscle, effects of ryanodine(crabs), 526

Calmodulin-mediated phosphodi-esterase activity, relationship

to hydro-osmotic actions ofantidiuretic hormone, effectsof fluoride (toads), 459

Captoprillong-term effects on cellular so-

dium content and mechanical

properties of aortic smooth

muscle (rats), 520pharmacological evaluation of

factors involved in renal vas-odilator effects of (dogs), 646

Carbachol, effect on cardiac re-sponsiveness to alpha andbeta adrenergic amines

(rats), 231Carbon tetrachloride, inhibition

of liver aldehyde dehydro-genase by (rats), 821

Carbonic anhydrase activity,renal, effect of ethacrynicacid (dogs), 505

Cardiovascular effects, central, oftaurmne, comparison with ho-motaurine and muscimol(cats), 213

1- and dl-Cathinone, behavioraleffects, comparison with d-amphetamine (monkeys), 355

Carla, V., see Sgaragli, G., 778Carroll-Buatti, M., see Pasternak,

G.W., 192Catecholamines (see also specific

name)in brain, effect of amphetamine

on release (rats), 49Cathepsin D, percentage bound in

myocardial ischemia, effectof ZK 36 374 (cats), 243

Cavero, I., Lef#{232}vre-Borg, F. andGomeni, R.: Heart rate low-ering effects of N,N-di-n-pro-pyl-dopamine in rats: By-dence for stimulation of cen-tral dopamine receptors lead-ing to inhibition of sympa-thetic tone and enhancementof parasympathetic outflow,

510Cell culture growth, inhibition of

amino acid transport by anti-

inflammatory drugs during(rats), 752

Cerebrospinal fluid, effect of hep-arm or salicylate acid onphenytoin in (rats), 42

CGS 4270, effect on sodium tram-port in skin (toads), 481

Chang, J.-K., see Tulunay, F. C.,296

Chang, Y.-H. and Bluestone, R.:Adjuvant polyarthritis. VI.Effect of oxonate-inducedhyperuricemia on the devel-opment of acute inflamma-tion, immune response andadjuvant arthritis, 731

Chausmer, A. B., see Nelson, T.

E., 107Cheney, D. L., see Brunello, N.,

489

Chloramphenicol succinate, phar-macokinetics (monkeys), 316

Chlordiazepoxide, behavioral ef-fects (monkeys), 199

Chloride, reabsorption in renal tu-bale, effect ofethacrynic acid(dogs), 505

Chlorisondamine, effect on

prejunctional adrenoceptorfunction (guinea pigs, rats),21

p-Chloroamphetamine, effect oncorticosterone secretion

(rats), 85p-Chlorophenylalarnne, effect on

serotonin contents in brainand taurine-induced hypo-thermia (rabbits), 778

Chlorpromazine, inhibition of de-oxycholate-induced secretionof intestinal fluid (dogs), 591

Choledochoduodenal junction,dual effect of morphine at(dogs), 274

Cholesterol 7a-hydroxylase, tro-leandomycin inhibition(rats), 558

Chou, R. C. and Levy, G.: Effectof heparin or salicylate infu-

sion on serum protein bindingand on concentrations ofphenytoin in serum, brainand cerebrospinal fluid ofrats, 42

Chu, B. C. F. and Howell, S. B.:Pharmacological and thera-peutic properties of carrierbound methotrexate againsttumor confined to a thirdspace body compartment, 389

Chymotrypsin, effect on SKF10,047 binding (rats, mice),192

Cirazoline, selectivity for periph-

eral alpha-i and alpha-2 ad-renoceptors (rats), 760

Circadian rhythm, pineal N-ace-tyltransferase, effect of lith-ium (rats), 121

Clearancerenal, of digoxin, effect of vol-

ume expansion and furose-mide diuresis (dogs), 54

renal, of zomepirac (monkeys),665

Clonidine, histamine-like effects(guinea pigs, rabbits), 474

Cocaine, effect on conditionedtaste aversion and schedule-controlled behavior (rats), 60

Colasanti, B. K., see Lindamood,C., III, 580

Collins, J. M., see McManus, M.B., 669

Colon, isolated, morphine-like ac-tion of FK 33-824 on motilityof (rats), 534

Collagen, lung, effect of lysyl oxi-dase activity (rats), 675

Commissaris, R. L., Lyness, W.H., Moore, K. E. and Rech,R. H.: Differential antago-nism by metergoline of thebehavioral effects of indole-alkylamine and phenethyla-mine hallucinogens in the rat,170

Contractile force, effect of stro-phanthidin and antimycin(dogs), 75

Contractile responsesof intralobar pulmonary arter-

ies and veins to 9a,1 la-epox-ymethanoprostaglandin H2

(dogs), 326of urinary bladder, develop-

ment of (rabbits), 250

Contractility, in isolated muscleof malignant hyperthermia

(pigs), 107Contraction

myometrial, mediation by al-pha receptor subtypes inuterus (rabbits), 290

vascular, relationship to cellu-lar sodium content, effect ofcaptopril (rats), 520

ventricle, effect of rubidium(guinea pigs), 573

Contractionsin heart and soleus muscle, ef-

fects of isosproterenol, pren-alterol and procaterol on(cats), 798

of isolated colon, effect of FK33-824 (rats), 534

Convulsions, insulin hypogly-

cemic, effect of gold thioglu-cose on sensitivity to (mice),

258

Cooxidation, renal, of acetamino-phen, prostaglandin endoper-oxide synthetase-dependent

(rabbits), 659Cordova, M. A., Bagwell, E. B.

and Lindenmayer, G. E.:Studies on the interaction ofpropranolol and tetrodotoxinon dV/dtmiix of canine Pur-kinje fiber action potentials,187

Corynanthine, pre- and postsyn-aptic alpha adrenoceptor se-

lectivity studies with (dogs),540

Counts, D. F., Evans, J. N., Di-petrillo, T. A., Sterling, K.

M., Jr. and Kelley, J.: Lysyloxidase activity in the lungincreases during bleomycin-induced lung fibrosis, 675

Cox, R. H., see Steele, J. W., 35Creatine kinase, specific activity

in myocardial ischemia, ef-

fect of ZK 36 374 (cats), 243Cyclic AMP

effect on activation of tyrosine

hydroxylase in portal vein

(rabbits), 97effect on neuronal firing in

brain (rats), 496

formation in spinal cord, aden-

osine regulation of (rats), 370production, relationship to hy-

dro-osmotic actions of phos-phodiesterase activity of an-

tidiuretic hormone, effect offluoride (toads), 459

Cyclic GMP

accumulation and 45Ca-uptakein ganglion, effect of pregan-

glionic nerve stimulation(rats), 338

formation, relationship to relax-

ation of coronary arterialsmooth muscle by glyceryltrinitrate, nitroprusside, ni-trite and nitric oxide (cows),181

Cyclooxygenase, inhibition, ef-fects on preventing coronaryarterial thrombosis (dogs),299

Cyclooxygenase activity, inhibi-tion, role in stimulation ofventilation and oxygen con-sumption (dogs), 723

Cytochrome P-450destruction by allylisopropyl-

acetamide (dog), 125

inhibition by pheneizine

through heme destruction(rats), 147

Czervionke, R. L., see Parks, W.M., 415

D-600, effect on adrenochrome-induced coronary artery con-striction in heart (rats), 225

Dajani, E. Z., see Gullikson, G.W., 591

Danis, M., Kauffman, F. C., Ev-ans, R. K. and Thurman, R.G.: Role of reducing equiva-Ients from fatty acid oxida-tion in mixed-function oxida-

tion: Studies with 2-bromooc-tanoate in the perfused ratliver, 383

Darius, H., see Schr#{246}r,243Davis, B. B., see Rapp, N. S., 442

Davis, B. B., see Zenser, T. V., 735

Davis, F. F., see Abuchowski, A.,352

de Jonge, A., see van Meel, J. C.A., 760

0-Demethylation, of p-nitroani-sole in isolated perfused liver,effect of 2-bromooctanoate(rats), 383

de Miranda, P., Krasny, H. C.,Page, D. A. and Elion, G. B.:The disposition of acyclovirin different species, 309

Dent, J. G., see Bond, J. A., 5982-Deoxy-D-glucose, effect on stro-

phanthidin-induced arrhyth-

832 Index Vol. 219

mias and contracture in car-diac Purkinje fibers (dogs), 75

Desmethylimipramine, inhibitorof agonist uptake effects(rats, guinea pigs), 112

Desmethylmisonidazole, in iso-

lated perfused liver, kineticsof (rats), 669

Desmosine, in lung, effect of bleo-mycin (rats), 675

Deoxycholate-induced intestinal

secretion, inhibition by anti-diarrheal drugs (dogs), 591

Dhalla, N. S., see Karmazyn, M.,225

Dial, E., Thompson, W. J. andRosenfeld, G. C.: Isolated pa-

rietal cells: Histamine re-sponse and pharmacology,585

Dietary lipid, effect on binding of

[‘H]dihydroalprenolol andadenylate cyclase activity in

atria (rats), 625Digoxin, renal clearance, effect of

volume expansion and furo-semide diuresis on (dogs), 54

[‘H]Dihydroalprenolol, binding in

atna, effect of dietary lipid(rats), 625

Dihydroergocryptine, binding torenal alpha-i and alpha -2

adrenergic receptors (rats),400

5,7-Dihydroxytryptamine, effect

on tolerance to hypnotic andhypothermic effects of

ethanol (mice), 175Diisobutyrylapomorphine, effect

on conditioned taste aversionand schedule-controlled be-havior (rats), 60

[2,4-”C]Dinitrotoluene, sex-de-pendent metabolism and bil-iary excretion in isolated per-fused liver (rats), 598

Dipetrillo, T. A., see Counts, D.F., 675

Dipyridamole, coronary dilatingeffects (dogs), 809

Disopyramide, binding to plasmaprotein, kinetics and dynam-ics (man), 741

Disposition, of propranolol, ef-fects of allylisospropylacet-

amide (dog), i25

Distribution, of chloramphenicolsuccinate (monkeys), 316

D’Mello, G. D., Goldberg, D. M.,Goldberg, S. R. and Stoler-

man, I. P.: Conditioned taste

aversion and operant behav-ior in rats: Effect of cocaine,

apomorphine and some long-acting derivatives, 60

Dobutamine, stereoisomers, al-pha and beta adrenergic ac-

tivities of (rats, cats), 447

Dols, D. M., see Silber, B., 125Dopamine, turnover, brain, ef-

fects of haloperidol and bu-taclamol (rats), 708

[‘H]Dopamine, in retina, modu-lation of stimulation-evokedrelease of (rabbits), 701

Douglas, J. S., see Brink, C., 1

Drack, B., see Scheurer, U., 534

Dubocovich, M. L. and Weiner,N.: Modulation of the stimu-lation-evoked release of [3H]dopamine in the rabbit ret-ma, 701

Dubois, A., see Shea-Donohue, P.T., 287

Duncan, P. G., see Brink, C., i

Duval, N., see Shepperson, N. B.,540

Dynorphin, possible regulatoryrole on morphine- and fl-en-dorphin-induced analgesia(mice), 296

Electrical properties, of muscle fi-bers, effects of ryanodine onionic currents and calciumconductance (crabs), 526

Electrodes, electrochemical, inbrain, calibration by acet-aminophen (rats), 49

Electrophysiological response, ofcerebellar Purkinje neurons

to leukotnene D4 and B4

(guinea pigs, rats), 91Elimination

dose- and time-dependent, ofacetaminophen (rats), 14

dose-dependent, of misonida-zole and desmethylmisonida-zole in isolated perfused liver

(rats), 669first-pass, hepatic, of propoxy-

phene, effect of ethanol(rats), 7

first-pass, of propranolol, ef-fects of allylisopropylacet-amide (dog), 125

of valproic acid by neonates(man), 768

Eling, T. E., see Boyd, J. A., 659Elion, G. B., see de Miranda, P.,

309

Elmamlouk, T. H., Mukhtar, H.and Bend, J. R.: The nuclearenvelope as a site of glucu-ronyltransferase in rat liver:

Properties of and effect of in-ducers on enzyme activity, 27

/3-Endorphin-induced analgesia,

possible regulatory role of dy-norphin on (mice), 296

Endothelium, platelet adherenceto, comparative effect of ibu-profen (man), 415

Enkephalin analogs-induced an-algesia, effect of dynorphinon (mice), 296

Enkephalins, effects on schedule-controlled behavior (rats),344

Enzyme, nuclear, properties andeffect of inducers on (rats), 27

Erlinger, S., see Le Dafniet, M.,

558

Estrogen, regulation, of alpha re-

ceptor subtypes in uterus

(rabbits), 290

Ethacrynic acid, effects on renaloxygen consumption, sodium,chloride and bicarbonate

reabsorption (dogs), 505Ethanol

effect on hepatic flrst-pass elim-

ination of propoxyphene

(rats), 7

hypnotic and hypothermic ef-fects, tolerance to (mice), 175

hypotensive effects (rats), 219N-Ethylmaleimide, effect on SKF

10,047 binding (rats, mice),192

Evans, J. N., see Counts, D. F.,675

Evans, R. K., see Danis, M., 383

Excretionbiliary, of [2,4-’4Cldinitrotol-

uene in isolated perfused liv-

em (rats), 598

biiary, of retinamide (rats), 632

of chloramphenicol succinate

(monkeys), 316

of styrene oxide-glutathione

conjugates and by liver, lungand kidney preparations(rats), 35

4-7-Exo-methylene-hexahydro-isoindoline-ethyl guanidinehemisulfate, adrenergic nerve

blocking activity of (cats),748

Fedan, J. S., see Wong, S. K., 163

Feigen, L. P., King, L. W., Ray, J.,Beckett, W. and Kadowitz, P.J.: Differential effects of ibu-profen and indomethacin inthe regional circulation of thedog, 679

Feldman, J., see Bousquet, P., 213Fibrosis, pulmonary, bleomycin-

induced, increased lysyl oxi-daze activity in lung during(rats), 675

Finch, C. E., see Randall, P. K.,695

Fischer, L. J., Green, M. D. andHarman, A. W.: Levels ofacetaminophen and its me-

tabolites in mouse tissuesafter a toxic dose, 281

Fish, K. W., see Luby, J. L., 258Fleming, W. W., see Wong, S. K.,

163Fliegel, L., see Karmazyn, M., 225Fluphenazine, effect on stimula-

tion-evoked release of [‘H]dopamine in retina (rabbits),701

a-Flupenthixol, effect on stimula-

tion-evoked release of [3H]dopamine in retina (rabbits),701

Food presentation, effects ofchiordiazepoxide and d-am-phetamine on respondingmaintained under schedulesof (monkeys), 199

N-[4-(5-nitro-2-furyl)-2-thiazoly]Formamide, in liver, kidneyand bladder, microsomal ni-troreductase activity (rab-bits), 735

Fredholm, B. B., see Luchelli-For-

tis, M. A., 235Freed, C. R., see Morgan, M. E.,

49Friedman, B. and Yocca, F. D.:

The effect of chronic lithiumtreatment on rat pineal N-

acetyltransferase rhythm,

121

Friedman, P., see Wong, P. C., 646

Fujiwara, M., see Ikushima, S.,

792Fukuzawa, K., see Tokumura, A.,

219-induced decrease in mesenteric

blood flow, role of volume de-pletion, antidiuretic hormone

and angiotensin II (dogs), 407Furosemide

diuresis, effect on renal clear-

ance of digoxin (dogs), 54

Gabathuler, M. L., see Kaufman,RD., 156

Gaffney, T. E., see Russell, M. P.,685

Galinsky, R. E. and Levy, G.:Dose- and time-dependentelimination of acetamino-phen in rats: Pharmacoki-netic implications of cosub-

strate depletion, 14Gaili, A., see Sgaragli, G., 778

Ganglion, superior cervical, cyclicGMP accumulation and �Ca-uptake during preganglionicstimulation, by (rats), 338

Ganglionic blockade, prejunc-tional adrenoceptor function

in vas deferens after (guineapig, rat), 21

Ganong, W. F., see Van De Kar,L. D., 85

Garcia, A. G., see Kirpekar, S. M.,

748

Gastric acid, secretion, inhibitionby histamine H2 receptor an-tagonists (rats), 585

Gerber, J. G., see Olson, R. D., 321

Gibson, T. P. and Quintanilla, A.P.: Effect of volume expan-sion and furosemide diuresis

on the renal clearance of di-goxin, 54

Glucuronide conjugationacetaminophen, kinetics of for-

mation (rats), 14of harmol, kinetics of (rats), 134

Glucuronyltransferase, in liver,nuclear envelope as site of(rats), 27

Glyceryl trinitrate, relationship

between cyclic GMP forma-tion and relaxation of coro-nary arterial smooth muscleby (cows), 18i

Goblet, C. and Mounier, Y.: Ef-fects of ryanodine on theionic currents and the cal-cium conductance in crabmuscle fibers, 526

Goldberg, D. M., see D’Mello, G.D., 60

Goldberg, S. R., see D’Mello, G.D., 60

Goldman, S., Olajos, M., Pieni-aszek, H., Perrier, D., May-ersohn, M., and Morkin, E.:Beta adrenergic blockadewith propranolol in consciouseuthyroid and thyrotoxiccalves: Dosage requirements

and effects on heart rate and

1981 Index 833

left ventricular performance,394

Gold thioglucose treatment, effecton sensitivity to insulin hy-poglycemic convulsions(mice), 258

Gomeni, R., see Cavero, I., 510Gorman, R. R., see Aiken, J. W.,

299

Goulart, D. A., see O’Reilly, R. A.,691

Graham, R. M., see Schmitz, J.M., 400

Grayanotoxin, modulation of so-dium channels of giant axon

by (squid), 614Green, M. D., see Fischer, L. J.,

281

Greenberg, S.: Effect of prostacy-chin and 9a,lia-epoxyme-thanoprostaglandin H2 on

calcium and magnesium

fluxes and tension develop-ment in canine intralobarpulmonary arteries and veins,326

Grubbs, J. H., see Hjelle, J. J., 821

Gruetter, C. A., Gruetter, D. Y.,Lyon, J. E., Kadowitz, P. J.and Ignarro, L. J.: Relation-ship between cyclic guano-sine 3’:5’-monophosphate for-mation and relaxation of cor-onary arterial smooth muscleby glyceryl trimtrate, nitro-

prusside, nitrite and nitric ox-ide: Effects ofmethylene blueand methemoglobin, 181

Gruetter, D. Y., see Gruetter, C.A., 181

Guanethidine, inhibition ofrelease of norepinephrine inspleen (cats), 748

Gullikson, G. W., Dajani, B. Z.and Bianchi, R. G.: Inhibitionof intestinal secretion in thedog: A new approach for themanagement of diarrhealstates, 591

Haigler, H. J., see Hosford, D. A.,496

Hallucinogens, indolealkylamineand phenethylamine, behav-ioral effects, antagonism bymetergoline (rats), 170

Haloperidol

effect on aging and regulationof striatal dopaminergic

mechanisms (mice), 695effect on [3H]spiroperidol bind-

ing and dopamine and sero-tonin turnover in brain (rats),

708

Halothane, effect on contracturein isolated muscle of malig-nant hyperthermia (pigs), 107

Halsema, I. C. M., see Pang, K. S.,134

Halter, F., see Scheurer, U., 534

Halushka, P. V., see Russell, M.P., 685

Harman, A. W., see Fischer, L. J.,281

Harmol, pharmacokinetics inliver, sulfate and glucuronide

conjugations (rats), 134

Hartmann, A., see Steen, P. A.,505

Hauser, I., see Nau, H., 768Heart

action potential, effects of quin-ide-propranolol interaction(dogs), 651

adrenochrome-induced coro-nary artery constriction in(rats), 225

artery, smooth muscle, effect of

methylene blue and methe-

moglobin on relationship be-

tween cyclic GMP formationand relaxation of (cows), i81

atria, responsiveness to alphaand beta adrenergic amines,

effects of carbachol and hy-pothyroidism (rats), 231

beta adrenoceptor interactionof full and partial agonists in(cats), 798

effect ofdietary lipid on binding

of [3H]dihydroalprenolol andadenylate cyclase activity in(rats), 625

effects of ZK 36 374 in myocar-dial ischemia (cats), 243

potassium-depolarized, effectsof papaverine on Ca��-de-pendent action potentials in

(guinea pigs), 715

Purkinje fibers action poten-

tials, interaction of propran-olol and tetrodotoxin on dV/

dtmax of (dogs), 187Purkinje fibers, effect of mets-

bolic inhibitors on strophan-thidin-induced arrhythmiasand contracture in (dogs), 75

ventricle, effects of rubidium on

contractility and sodiumpump activity in (guineapigs), 573

Heart rate

bradycardia, effects of N,N-di-n-propyl-dopamine (rats,

dogs), 510effect of azepoxole (rats), 786effect of beta adrenergic block-

ade (calves), 394effects of taurine, homotaurine

and muscimol (cats), 213Hedberg, A. and Mattsson, H.:

Beta adrenoceptor interac-

tion of full and partial ago-nists in the cat heart and so-leus muscle, 798

Helge, H., see Nau, H., 768

Heme, destruction, inhibition ofcytochrome P-450 by phenel-zine through (rats), 147

Henderson, B. G., see Volle, R. L.,338

Henry, S., see Yorio, T., 459Heparmn, effect on serum protein

binding and on phenytoin in

serum, brain and cerebrospi-nal fluid (rats), 42

Hernandez, 0., see Steele, J. W.,35

Hen, A., see Schultz, R., 547

High-performance liquid chro-matography, method foranalysis of acetaminophen

and metabolites in tissues(mouse), 281

Histamineeffect on response and sensitiv-

ity of lung parenchymalstrips (guinea pigs), 1

effect on sensitized pulmonary

blood vessels (dogs), 551release, effect of tolazoline and

clonidine (guinea pig, rab-bits), 474

Hjelle, J. J., Grubbs, J. H., Beer,D. G. and Petersen, D. R.:Inhibition of rat liver alde-hyde dehydrogenase by car-bon tetrachloride, 821

Hoak, J. C., see Parks, W. M., 415

Hoffer, B. J., see Palmer, M. R.,91

Hoffman, B. B., Lavin, T. N., Lef-

kowitz, J. and Ruffolo, R. R.,

Jr.: Alpha adrenergic recep-

tor subtypes in rabbit uterus:Mediation of myometrialcontraction and regulation byestrogens, 290

Holiday, J. F., see Luby, J. L., 258

Holtzman, S. G., see Brady, L. S.,344

Homotaurine, central cardiovas-cular effects, comparisonwith taurine (cats), 213

Hormones (see also Specific

name)Hosford, D. A. and Haigler, H. J.:

Cyclic AMP, morphine, met-enkephalin and neuronal fir-

ing, 496

Hough, L. B. and Barker, L. A.:

Histamine H2-receptor an-

tagonism by propanthelineand derivatives, 453

Howell, S. B., see Chu, B. C. F.,389

Huang, K. C., see Williams, W.M., 69

Hydralazine, antihypertensive ac-tions (rats), 520

Hydro-osmotic response, of tin-

nary bladder to antidiuretichormone, fluoride inhibition(toads), 459

6-Hydroxydopamine

effect on [3H]ouabain bindingto smooth muscle vas defer-ens (guinea pigs), 163

effect on tolerance to hypnoticand hypothermic effects ofethanol (mice), 175

Hydroxyproline, in lung, effect ofbleomycin (rats), 675

5-Hydroxytryptamine (see alsoSerotonin)

involvement in behavioral ef-fects of indolealkylamine andphenethylamine hallucino-gens (rats), 170

Hypoglycemia, insulin, effect ofgold thioglucose on response

of brain to (mice), 258

Hypotension, nitroprusside-in-duced, effects on sympathetic

nerve activity, tyrosine hy-

droxylase activity and [2H]norepinephrine uptake (rab-bits), 420

Hyperthermia, malignant, cal-cium content and contracture

in isolated muscle of (pigs),

107

Hyperuricemia, oxonate-induced,effect on development of

acute inflammation, immune

response and adjuvant ar-

thritis (rats), 731

Hypotension, by lysophosphatidicacid and its analogs (rats),219

Hypothalamus, ventromedial, ef-

fect of gold thioglucose on

(mice) 258

Hypothyroidism, effect on cardiac

responsiveness to alpha andbeta adrenergic amines

(rats), 231

Iansmith, D. H. S., Bandura, J. P.

and Nash, C. B.: A microelec-

trophysiologic analysis of thepharmacodynamic basis forquinidine-propranolol antiar-

rhythmic potentiation, 651

Ibuprofen

circulatory effects (dogs), 679comparative effect on endothe-

hal and platelet prostaglan-

din synthesis (man), 415effect on oxygen consumption

and ventilation, role ofcyclooxygenase inhibition

(dogs), 723

Ignarro, L. J., see Gruetter, C. A.,181

Ikushima, S., Muramatsu, I. andFujiwara, M.: Effects of 4-aminopyridine on the adre-nergic nerve terminals of rab-bit arteries, 792

Ileum, tolerance development in

opiate receptors in (guineapigs), 547

Immune response, effect of oxon-ate-induced hyperuricemia

(rats), 731Impulse-flow, within septal-hip-

pocampal cholinergic path-way of brain, interaction withL�9 - tetrahydrocannabinol

(rats), 580

Indolealkylamine, hallucinogens,behavioral effects, antago-

nism by metergoline (rats),

170

Indomethacincirculatory effects (dogs), 679

effect on oxygen consumption

and ventilation, role of cy-

clooxygenase inhibition(dogs), 723

inhibition of a-methylaminoiso-

butyric acid transport by

(rats), 752role in renal vasodilator effect

of captopril (dogs), 646

Inflammation, acute, effect of ox-

onate-induced hyperuncemia

(rats), 731

Intestine, fluid secretion, deoxy-cholate-induced, inhibition

by antidiarrheal drugs (dogs),

591

lodoacetamide, effect on SKF

834 Index Vol. 219

10,047 binding (rats, mice),192

lodoacetic acid, effect on stro-phanthidin-induced arrhyth-

mias and contracture in car-diac Purkinje fibers (dogs), 75

Ionic channel complex, in skeletal

muscle, effect of ketamine(frog, rats), 638

Ionic currents, in muscle fibers,effects of ryanodine on

(crabs), 526Isoproterenol, effect on beta ad-

renoceptor occupancy, ade-nylate cyclase activity andmuscle contraction in heart

and soleus muscle (cats), 798

Ito, K., Koike, H., Miyamoto, M.,Ozaki, H., Kishimoto, T. andUrakawa, N.: Long-term ef-fects of captopril on cellularsodium content and mechan-ical properties of aortic

smooth muscle from sponta-

neously hypertensive rats,

520

Jacobowitz, D., see Levin, R. M.,

250

Jacobs, R. S., see Burley, E. S.,268

Jen, M.-F., see Tulunay, F. C., 296Johanson, C. E. and Schuster, C.

R.: A comparison of I- and dl-cathinone and d-amphet-amine, 355

Johnson, E. E.: Morphine: A dualeffect at the canine choledo-choduodenal junction, 274

Johnson, M. R., see Mdllhenny,H. M., 363

Jones, D. J.: Adenosine regulationof cyclic 3’,5’-adenosinemonophosphate formation in

rat spinal cord, 370

Kadowitz, P. J., see Feigen, L. P.,679

Kadowitz, P. J., see Gruetter, C.A., 181

Kainic acid, effect on metabolismof acetylcholine (rats), 489

Kapil, R. P., see Tam, Y. K., 141

Karmazyn, M., Beamish, R. B.,Fliegel, L. and Dhalla, N. S.:Adrenochrome-induced cor-onary artery constriction inthe rat heart, 225

Karp, D., see Abuchowski, A., 352

Katz, J. L., see Barrett, J. E., 199

Kauffman, F. C., see Danis, M.,383

Kaufman, R. D., Gabathuler, M.L. and Bellville, J. W.: Po-tency, duration of action andpA2 in man of intravenousnaloxone measured by rever-sal of morphine-depressed

respiration, 156

Kelley, J., see Counts, D. F., 675Kenakin, T. P. and Angus, J. A.:

The histamine-like effects oftolazoline and clonidine: By-

idence against direct activityat histamine receptors, 474

Kenakin, T. P. and Beek, D.: The

measurement of antagonistpotency and the importanceof selective inhibition of ago-nist uptake processes, 112

Ketamine, effect on acetylcholinereceptor/ionic channel com-plex (frogs, rats), 638

Kidney

amioride secretion, electrolyteeffects (chickens), 435

bradykinin stimulation of med-ullary prostglandin E2 syn-thesis, inhibition by phospho-

diesterase inhibitors (rab-bits), 442

clearance of digoxin, effect ofvolume expansion and furo-semide diuresis (dogs), 54

clearance of zomepirac (mon-keys), 665

effects of ethacrynic acid on ox-ygen consumption, sodium,

chloride and bicarbonate

reabsorption in (dogs), 505

experimental dysfunction, me-

todopramide pharmacokinet-ics (rats), 141

isolated perfused, metabolismand excretion of styrene ox-ide-glutathione conjugates

(rats), 35

microsomal nitroreductase ac-tivity (rabbits), 735

prostaglandin endoperoxidesynthetase-dependent cooxi-

dation of acetaminophen in(rabbits), 659

renin secretion, effect of brainserotonin (rats), 85

tissue, heavy metal inhibition ofp-aminohippurate transport

in (fish), 428

tubular bidirectional amino

acid transport, structuralspecificity (dogs), 69

vasoconstriction, effect of al-p/ia-i and alpha-2 adrener-gic receptors (rats), 400

vasoconstrictor response, effect

of arachidonic acid (dogs),377

vasodilator effects of captopril

in (dogs), 646

Kiil, F., see Steen, P. A., 505

Kinetics (see also Pharmacoki-netics)

nonlinear, of acetaminophen(rats), 14

of acyclovir (mice, rats, dogs,

monkeys), 309of disopyramide binding to

plasma protein (man), 741

of misonidazole and desmethyl-

misonidazole in isolated per-fused liver (rats), 669

of sodium channel of giantaxon, effect of grayanotoxin(squid), 614

of tetramethrin-modified so-

dium channel in giant axon(squid), 464

King, L. W., see Feigen, L. P., 679Kirpekar, S. M., Garcia, A. G. and

Prat, J. C.: Adrenergic nerve-blocking activity of a newguanidine derivative, 748

Kishimoto, T., see Ito, K., 520

Knight, R. G. and Nosek, T. M.:Effects of rubidium on con-

tractiity and sodium pumpactivity in guinea-pig ventri-cle, 573

Koch, S., see Nau, H., 768

Koike, H., see Ito, K., 520

Kong, S-K. and Stephens, N. L:Pharmacological studies of

sensitized canine pulmonary

blood vessels, 551

Koster, H., see Pang, K. S., 134

Kounenis, G., see Wong, P. C., 646

Koup, J. R., Weber, A. and Smith,A. L.: Chloramphenicol suc-cinate pharmacokinetics inMacaca nemestrina: Dosedependency study, 316

Kraft, B., see Wong, P. C., 646

Krasny, H. C., see de Miranda, P.,309

Kume, T., see Tokumura, A., 219Kuna, S. T. and Levine, S.: Rela-

tionship between cyclooxy-genase activity (COA) inhi-bition and stimulation of yen-

tilation by salicylate, 723

Li210 tumor, confined to thirdspace body compartment, ef-fect of methotrexate (mice),389

Langer, S. Z., see Luchelli-Fortis,M. A., 235

Lau, S. S. and Zannoni, V. G.:

Bromobenzene epoxidationleading to binding on macro-

molecular protein sites, 563

Lawn, T. N., see Hoffman, B. B.,

290

Le Dafniet, M., Pessayre, D., LeQuernec, L. and Erlinger, S.:Effects oftroleandomycin ad-ministration on cholesterol

7a-hydroxylase activity andbile secretion in rats, 558

Lee, N. M., see Tulunay, F.C., 296Lef#{232}vre-Borg, F., see Cavero, I.,

510Lefkowitz, R. J., see Hoffman, B.

B., 290

Le Quernec, L., see Le Dafniet,

M., 558

Leukotriene B4, electrophysiolog-ical response of cerebellarPurkinje neurons to (guineapigs, rats), 9i

Leukotnene D4, electrophysiolog-ical response of cerebellar

Purkinje neurons to (guineapigs, rats), 91

Levin, R. M., Malkowicz, S. B.,

Jacobowitz, D. and Wein, A.J.: The ontogeny of the au-tonomic innervation and con-tractile response ofthe rabbiturinary bladder, 250

Levine, S., see Kuna, S. T., 723Levy, G., see Chou, R. C., 42Levy, G., see Galinsky, R. B., 14

Levy, G., see Oguma, T., 7

Lidamidine, inhibition of deoxy-cholate-induced secretion of

intestinal fluid (dogs), 59i

Lilly 1 10140, effect on serotonin

contents in brain and taurine-induced hypothermia (rab-bits), 778

Lima, J. J., Boudoulas, H. andBlanford, M.: Concentration-dependence of disopyramidebinding to plasma proteinand its influence on kineticsand dynamics, 741

Lindamood, C., III and Colasanti,B. K.: Interaction betweenimpulse-flow and �9-tetrahy-drocannabinol within theseptal-hippocampal cholin-ergic pathway of rat brain,580

Lindenmayer, G. B., see Cordova,M.A., 187

Lithium, effect on pineal N-ace-

tyltransferase rhythm (rats),

121

Liveraldehyde dehydrogenase, inhi-

bition by carbon tetrachlo-ride (rats), 821

effect of ethanol on first-passelimination of propoxyphenein (rats), 7

experimental dysfunction, me-

toclopramide pharmacoki-netics (rats), 141

isolated perfused, kinetics of

misonidazole and desmethyl-

misonidazole in (rats), 669

isolated perfused, metabolism

and excretion of styrene ox-ide-glutathione conjugates(rats), 35

isolated perfused, sex-depen-

dent metabolism and biiaryexcretion of [2,4-’4C]dinitro-

toluene in (rats), 598

isolated perfused, studies with2-bromooctanoate on mixed-function oxidase ofp-nitroan-

isole in (rats), 383

microsomal binding of [‘4C]practolol metabolites (ham-sters, rats, guinea pigs, mar-mosets), 207

microsomal drug metabolism,inhibition by phenelzine(rats), 147

microsomal nitroreductase ac-tivity (rabbits), 735

nuclear envelope as site of glu-

curonyltransferase in (rats),27

perfused, pharmacokinetics of

harmol in (rats), 134

Loh, H. H., see Tulunay, F. C.,296

Lowery, C., see Orton, T. C., 207Luby, J. L., Holiday, J. F., Fish,

K. W. and Marrazzi, M. A.:Change in sensitivity to in-

sulin hypoglycemic convul-sions after gold thioglucose

treatment: Time course of de-velopment, 258

Luchelli-Fortis, M. A., Fredholm,

B. B. and Langer, S. Z.: Evi-dence against the presence ofpresynaptic inhibitory aden-osine receptors in the cat mc-titating membrane, 235

1981 Index 835

Lund, A. E. and Narahashi, T.:Kinetics of sodium channel

modification by the insecti-cide tetramethrin in squidaxon membranes, 464

Lungincreased lysyl oxidase activity

during bleomycin-induced

pulmonary fibrosis in (rats),675

isolated perfused, metabolismand excretion of styrene ox-ide-glutathione conjugates(rats), 35

parenchymal strips, agonist re-sponses in (guinea pigs), 1

sensitized blood vessels, phar-macological studies of (dogs),

551

Lyness, W. H., see Commissaris,R.L, 170

Lyon, J. E., see Gruetter, C. A.,181

Lysophosphatidic acid, cardiovas-cular effects (rats), 219

Lysyl oxidase, increased activityin the lung during bleomycin-induced pulmonary fibrosis(rats), 675

Macula densa-mediated reninrelease (dogs), 321

Magnani, M., see Sgaragli, G., 778Magnesium, fluxes, in intralobar

pulmonary arteries and veins,effect of prostacyclin and 9a,1 1 a - epoxymethanoprosta-glandin H2 on (dogs), 326

Maleque, M. A., Warnick, J. B.and Albuquerque, E. X.: Themechanism and site of actionof ketamine on skeletal mus-cle, 638

Malik, K. U., see Suli#{233},H., 377

Malkowicz, S. B., see Levin, R.

M., 250

Manganese chloride, effect onSKF 10,047 binding (rats,mice), 192

Marrazzi, M. A., see Luby, J. L.,

258Massingham, R., see Shepperson,

N. B., 540

Mast, R. W., see Mdllhenny, H.

M., 363Mathews, W. R., see Palmer, M.

R., 91Mattammal, M. B., see Rapp, N.

S., 442Mattammal, M. B., see Zenser, T.

V., 735Mattsson, H., see Hedberg, A., 798

Mayersohn, M., see Goldman, S.,394

McErlane, B., see Tam, Y. K., 141Mcllhenny, H. M., Mast, R. W.,

Johnson, M. R. and Mine, G.M.: Nantradol hydrochloride:Pharmacokinetics and be-havioral effects after acuteand chronic treatment, 363

McKown, L A., see O’Neill, P. J.,665

McManus, M. E., Monks, A., Col-ins, J. M., White, R. andStrong, J. M.: Nonlinear

pharmacokinetics of misoni-

dazole and desmethymisoni-dazole in the isolated per-

fused rat liver, 669

McNeil, J. H., see Simpson, W.W., 231

Medinsky, M. A., see Bond, J. A.,598

Meichior, C. L. and Tabakoff, B.:Modification of environmen-tally cued tolerance to

ethanol in mice, 175Mercury, inhibition of p-amino-

hippurate transport in renaltissue (fish), 428

Metabolism

and bioactivity of retinamide(rats), 632

calcium, role in responses of

malignant hyperthermia

(pigs), 107

drug, inhibition by phenelzine(rats), 147

drug, role in toxicity of acet-aminophen (mice), 281

drug, role offatty acid oxidation(rats), 383

ofacetaminophen (rabbits), 659

of acetylcholine, effects of bi-

cucuffine, thyrotropin-releas-ing hormone and kainic acid(rats), 489

of [2,4-’4C]dinitrotoluene, sex-

dependent (rats), 598of glucose (mice), 258of metoclopramide (rats), 141

of nantradol hydrochloride(mice, rats, dogs), 363

or practolol (hamsters, rats,guinea pigs, marmosets), 207

of propranolol (dogs, rabbits,man), 685

of styrene oxide-glutathione

conjugates and by liver, lungand kidney preparations(rats), 35

propranolol, effects of allyliso-propylacetamide (dog), 125

Metabolites, [‘4C]practolol, bind-ing to liver microsomes (ham-sters, rats, guinea pigs, mar-mosets), 207

Metanephrine, inhibitor of ago-nist uptake effects (rats,guinea pigs), 112

Metergoline, antihallucinogenicactions of (rats), 170

Methantheline, histamine H,-re-ceptor antagonism by (guineapigs), 453

Methemoglobin, effect on rela-tionship between cyclic GMP

formation and relaxation ofcoronary arterial smooth

muscle (cows), 181Methionine-enkephalin

analog FK 33-824, morphine-like action on colonic motility(rats), 534

effect on neuronal firing inbrain (rats), 496

Methotrexate, pharmacokinetics

and therapeutic effects(mice), 389

Methoxamine, selectivity for pe-ripheral alpha-i and alpha-2

adrenoceptors (rats), 760

Methylene blue, effect on rela-tionship between cyclic GMPformation and relaxation ofcoronary arterial smooth

muscle (cows), 181

a-Methyl-p-tyrosine, effect on tol-erance to hypnotic and hy-pothermic effects of ethanol

(mice), i75

4’-Methylthiopropranolol, pro-pranolol analog, cardiovas-cular effects (dogs, rabbits,man), 685

Methysergide, effect on serotonincontents in brain and taurine-induced hypothermia (rab-bits), 778

Metoclopramideeffect on stimulation-evoked

release of [3H]dopamine inretina (rabbits), 701

pharmacokinetics (rats), 141

Mico, B. A., see Silber, B., 125Microsomal enzymes, troleando-

mycin induction (rats), 558

Miller, D. S.: Heavy metal inhi-bition of p-aminohippuratetransport in flounder renaltissue: Sits of HgCl action,

428Miller, 0. V., see Aiken, J. W., 299

Mine, G. M., see Mcllhenny, H.M., 363

Misonidazole, in isolated perfusedliver, kinetics of (rats), 669

Miyamoto, M., see Ito, K., 520Monks, A., see McManus, M. E.,

669

Moore, K. E., see Commissaris, R.

L., 170

Morgan, M. E. and Freed, C. R.:Acetaminophen as an inter-

nal standard for calibratingin vitro electrochemical elec-trodes, 49

Morkin, E., see Goldman, S., 394

Morphine

analgesia, effect of naloxone(rats, mice), 192

-depressed respiration, potency,duration of action and pA2 ofnaloxone in reversal of (man),i56

dual effect at choledochoduo-

denal junction (dogs), 274

effect on neuronal firing in

brain (rats), 496

effects on schedule-controlledbehavior (rats), 344

effect on withdrawal responsesof azepexole (rats), 786

-induced analgesia, possibleregulatory role of dynorphin

on (mice), 296

-like action of methionine-en-kephalin analog FK 33-824 on

colonic motility (rats), 534Mounier, Y., see Goblet, C., 526Muakkassah, S. F. and Yang, W.

C. T.: Mechanism of the in-hibitory action of phenelzineon microsomal drug metabo-lism, 147

Mukhtar, H., see Elmamlouk, T.H., 27

Mulder, G. J., see Pang, K. S., 134

Muramatsu, I., see Ikushima, S.,792

Murphy, P. J., see Ruffolo, R. R.,Jr., 447

Murphy, R. C., see Palmer, M. R.,91

Muscimol, central cardiovascular

effects of, comparison with

taurine (cats), 213

Musclepapillary, alpha and beta adre-

nergic activities of dobutam-me stereoisomers (rats, cats),

447

skeletal, ionic currents and cal-

cium conductance, effects of

ryanodine (crabs), 526skeletal, mechanism and site of

action of ketamine on (frogs,

rats), 638

skeletal, of malignant hyper-

thermia, calcium content and

contracture in (pigs), 107smooth, aortic, mechanical

properties, long-term effectsof captopnil (rats), 520

smooth, coronary arterial, re-taxation by glyceryl trini-trate, nitroprusside, nitrite

and nitric oxide, relationshipwith cyclic GMP formation(cows), i8i

smooth, of vas deferens, Na-K

pump sites (guinea pigs), 163

smooth, vascular, responses to

prostaglandins (dogs), 326soleus, beta adrenoceptor inter-

action of full and partial ag-

onists in (cats), 798Muscle fibers, skeletal, skinned,

action of pnilocaine on sarco-

plasmic reticulum in (frogs),815

Myocardial ischemia, effects of

ZK 36 374 in (cats), 243

Nakamura, M., see Noguchi, K.,

809

Naloxazoneeffect on binding and analgesic

properties of SKF 10,047

(rats, mice), 192-elicited choledochoduodenal

contractions (dogs), 274morphine and enkephalin an-

tagonism by (rats), 344

potency, duration of action and

pA2 in reversal of respiratory

depression by morphine

(man), 156

Nantradol hydrochloride, phar-macokinetics and behavioraleffects (mice, rats, dogs), 363

Narahashi, T., see Lund, A. B.,464

Narahashi, T., see Seyama, I., 614

Nash, C. B., see Iansmith, D. H.S., 651

Nau, H., Rating, D., Koch, S.,Hauser, I. and Helge, H.: Val-proic acid and its metabo-

lites: Placental transfer, neo-natal pharmacokinetics,

transfer via mother’s milkand clinical status in neo-

836 Index

nates of epileptic mothers,

768Nelson, T. B. and Chausmer, A.

B.: Calcium content and con-tracture in isolated muscle ofmalignant hyperthermia inpigs, 107

Neonate, effects of valproic acid(man), 768

Neostigmine, inhibitory action on

morphine at choledochoduo-denal junction by (dogs), 274

Nerve

adrenergic, blocking activity ofguanidine derivative (cats),

748adrenergic, myocardial is-

chemia, effect of ZK 36 374(cats), 243

giant axon, kinetics of sodiumchannel modification by te-tramethrin in (squid), 464

giant axon, sodium channels,modulation by grayanotoxin

(squid), 6i4sympathetic, activity, effects of

nitroprusside-induced hypo-

tension on (rabbits), 420Nerve terminals, adrenergic, in

thoracic aorta and pulmo-nary arteries, effects of

aminopyridine on (rabbits),

792

Nervous system, central, effects of

taurine on (cats), 2i3Neurons

cerebral cortical and Purkinje,inhibitory effects of taurine

and fl-alanine (rats), 604in mesencephalic reticular for-

mation, effects of cyclic

AMP, morphine and methio-nine-enkephalin on firing

(rats), 496Purkinje, cerebellar, electro-

physiological response to leu-kotriene D4 and B4 (guineapigs, rats), 91

serotonergic, effect on renin se-

cretion (rats), 85

Neurotransmission, noradrener-

gic, effect of prejunctionaladrenoceptor regulation

(guinea pigs, rats), 21

Newton, D. L., see Swanson, B.N., 632

Nictitating membrane, evidence

against presence of presyn-aptic adenosine receptors in(cats), 235

Nicotine, stimulation of adrener-

gic nerve terminals in tho-racic aorta and pulmonaryarteries (rabbits), 792

Nies, A. S., see Olson, R. S., 321

Nitric oxide, relationship betweencyclic GMP formation andrelaxation of coronary site-rial smooth muscle by (cows),181

Nitrite, relationship betweencyclic GMP formation andrelaxation of coronary site-rial smooth muscle by (cows),181

p-Nitroanisole, mixed-function

oxidation in isolated perfusedliver, studies with 2-bromooc-tanoate (rats), 383

p-Nitrobenzoic acid, in liver, kid-

ney and bladder, microsomal

nitroreductase activity (rab-bits), 735

5-Nitrofuran-induced toxicity, inliver, kidney and bladder(rabbits), 735

Nitroglycerin, coronary dilating

effects (dogs), 809Nitroprusside

-induced hypotension, effectson sympathetic nerve activ-ity, tyrosine hydroxylase ac-tivity and [3H]norepineph-rise uptake in vascular tis-

sues (rabbits), 420

relationship between cyclicGMP formation and relaxa-tion of coronary arterial

smooth muscle by (cows), 181

Noguchi, K., Tomoike, H., Oot-subo, H., Sakai, K. and Nak-

amura, M.: Difference in siteand time course of coronarydilating effects of trapidil, ni-

troglycerin and dipyridamolein anesthetized dogs, 809

Nompleggi, D., see Shea-Dono-

hue, P. T., 287Norepinephrine

effect on isolated nerve-smoothmuscle of nictitating mem-

brane (cats), 235effect on sensitized pulmonary

blood vessels (dogs), 551

effect on tolerance to hypnoticand hypothermic effects ofethanol (mice), 175

-elicited renal vasoconstrictor

response, effect of arachi-domc acid on (dogs), 377

release during nerve stimula-tion, effect of alpha adreno-

ceptors (guinea pigs, rats), 21release, effect of presynaptic al-

pha adrenoceptors (dogs),

540

release in spleen, effect of guan-idine derivative (cats), 748

[3H]Norepinephrine, uptake in

vascular tissues, effects of m-troprusside-induced hypo-tension (rabbits), 420

Nosek, T. M., see Knight, R. G.,573

Nuclear envelope, as site of glu-curonyltransferase in liver(rats), 27

Oguma, T. and Levy, G.: Acuteeffect of ethanol on hepatic

first-pass elimination of pro-poxyphene in rats, 7

Ohlendorf, R., see Schrdr, 243

Olajos, M., see Goldman, S., 394

Olson, R. D., Nies, A. S. and Ger-

ber, J. G.: Alpha adrenergic-

mediated renin release isprostaglandin - dependent,321

O’Neill, P. J., Yorgey, K. A. and

McKown, L. A.: Dose-depen-dent pharmacokinetics and

renal handling of zomepiracin rhesus monkeys, 665

Ongley, R., see Tam, Y. K., 141

Ootsubo, H., see Noguchi, K., 809

Opiate, sigma, SKF 10,047, bind-ing and analgesic properties(rats, mice), 192

O’Reilly, R. A. and Goulart, D. A.:Comparative interaction ofsulfinpyrazone and phenyl-

butazone with racemic war-farm: Alteration in vivo of

free fraction of plasma war-

farm, 691Ortiz de Montellano, B. A., see

Silber, B., 125

Orton, T. C. and Lowery, C.: Prac-tolol metabolism. III. Irre-

versible binding of [‘4C]prac-tolol metabolite(s) to mam-

malian liver microsomes, 207Ouabain, effect on cyclic GMP ac-

cumulation in ganglion (rats),

338

[3H]Ouabain, binding to smooth

muscle of vas deferens

(guinea pigs), 163

Oxidation, mixed-function, of p-nitroanisole in liver, studieswith 2-bromooctanoate(rats), 383

Oxygen, renal consumption, effectof ethacrynic acid (dogs), 505

Oxygen consumption, role of cy-clooxygenase inhibition on(dogs), 723

Ozaki, H., see Ito, K., 520

Page, D. A., see de Miranda, P.,309

Palmer, M. R., Mathews, W. R.Hoffer, B. J. and Murphy, R.C.: Electrophysiological re-sponse of cerebellar Purkinje

neurons to leukotriene D4and B4, 91

Palmier, M. 0., see Zenser, T. V.,735

1-Palmitoyl-2-acetoyl-sn-glycero-

3-phosphorylmethanol, hy-

potensive effect (rats), 219Pang, K. S., Koster, H., Halsema,

I. C. M., Scholtens, E. andMulder, G. J.: Aberrant phar-macokinetics ofharmol in theperfused rat liver prepara-tion: SuLfate and glucuronide

conjugations, 134Papaverine, effects on Ca�-de-

pendent action potentials inpotassium-depolarized heart(guinea pigs), 715

Parietal cells, isolated, stomach,

histamine response and phar-

macology (rats), 585

Parks, W. M., Hoak, J. C. andCzervionke, R. L.: Compara-tive effect of ibuprofen on en-

dothelial and platelet prosta-glandin synthesis, 415

Pasternak, G. W., Carroll-Buatti,M. and Spiegel, K.: The bind-ing and analgesic properties

Vol. 219

of a sigma opiate, SKF

10,047, 192Patterson, B. A., see Volle, R. L.,

338

Peet, N. P., see Russell, M. P., 685

Pentobarbitaleffect on activation of tyrosine

hydroxylase in portal vein(rabbits), 97

effect on turnover rate of ace-

tylcholine in brain (rats), 489Perrier, D., see Goldman, S., 394Pessayre, D., see Le Dafniet, M.,

558

Petersen, D. R., see Hjelle, J. J.,821

Pettinger, W. A., see Schmitz, J.M., 400

Pharmacokinetics (see also Ki-netics)

and therapeutic effects of meth-otrexate (mice), 389

of chloramphenicol succinate(monkeys), 316

of harmol in liver (rats), 134

of metoclopramide (rats), 141of nantradol hydrochloride

(mice, rats, dogs), 363

of valproic acid (man), 768

of zomepirac (monkeys), 665Pharmadynamics, of disopyram-

ide binding to plasma protein

(man), 741Phenelzine, inhibitory action on

microsomal drug metabolism(rats), 147

Phenethylamine, hallucinogens,

behavioral effects, antago-nism by metergoline (rats),

170

Phenylalanine, renal tubulartransport, structural specific-

ity (dogs), 69Phenylbutazone, and sulfinpyra-

zone, comparative interac-

tion with racemic warfarin

(man), 691

Phenylephrine, effect on reninrelease (dogs), 321

(-)-Phenylephrine, selectivity forperipheral alpha-i and al-pha-2 adrenoceptors (rats),760

Phenytoin, in serum, brain andcerebrospinal fluid, effect ofheparin or salicylate acid(rats), 42

Phosphodiesterase inhibitors, in-hibition of bradykinin stimu-

lation of renal medullaryprostaglandin E2 synthesis by(rabbits), 442

Phospholipids, cardiovascular ef-

fects (rats), 219Pieniaszek, H., see Goldman, S.,

394Placental transfer, ofvalproic acid

(man), 768

Plasmaurate levels, reduction with

polyethylene glycol-uricase(cockerels, rats), 352

warfarmn, free fraction, effects ofsulfinpyrazone and phenyl-butazone (man), 691

1981 Index 837

Plasma binding, of acyclovin(mice, rats, dogs, monkeys),309

Platelet

and endothelial prostaglandinsynthesis, comparative effectof ibuprofen (man), 415

-dependent coronary arterythrombosis, contribution ofprostacyclin to preventive ef-fect of thromboxane synthe-

tase inhibitors (dogs), 299Platelet count, blood, in myocar-

dial ischemia, effect of ZK 36374 (cats), 243

Pollock, G. D., see Ruffolo, R. R.,Jr., 447

Polyethylene glycol-uricase, re-duction of plasma uratelevels with (cockerels, rats),352

Potassium-depolarized heart, ef-

fects of papaverine on Ca�-dependent action potentialsin (guinea pigs), 715

Potassium channel blockade, ef-fect of 4-aminopyridine(frogs), 268

Potencyof antagonist, measurement

(rats, guinea pigs), 112of naloxone in reversal of mor-

phine-depressed respiration(man), 156

Potentialsaction, Ca��-dependent, in po-

tassium-depolarized heart,

effects of papaverine on

(guinea pigs), 715

action, in adrenergic nerve ter-minals, effects of 4-aminopyr-idine (rabbits), 792

action, in heart, effects of quin-idine-propranolol interaction

(dogs), 651

action, in Purkinje fibers, inter-action of propranolol and tet-rodotoxin on dV/dt� of(dogs), 187

action, in ventricle, effect of ru-

bidium (guinea pigs), 573action, of skeletal muscle, effect

of ketamine (frogs, rats), 638nerve terminal action and end-

plate, effects of 4-aminopyri-

dine on (frogs), 268

oscillatory and action, effect ofstrophanthidin (dogs), 75

Potentiation, quinidine, propran-olol-induced, antiarrhythmic

actions (dogs), 651Practolol, metabolism (hamsters,

rats, guinea pigs, marmosets),207

Prat, J. C., see Kirpekar, S. M.,

748Prazosin, binding to renal alpha-

1 adrenergic receptors (rats),

400Prenalterol, effect on beta adre-

noceptor occupancy, adenyl-ate cyclase activity and mus-

cle contraction in heart andsoleus muscle (cats), 798

Price, J. D. B., see Tam, Y. K.,

141

Pnilocaine, action on sarcoplasmicreticulum in skinned skeletalmuscle fibers (frogs), 815

Privitera, P. J., see Russell, M. P.,685

Procaterol, effect on beta adre-noceptor occupancy, adenyl-ate cyclase activity and mus-cle contraction in heart andsoleus muscle (cats), 798

Propantheline, histamine H2-re-ceptor antagonism by (guineapigs), 453

Propoxyphene, hepatic first-passelimination, effect of ethanol(rats), 7

Propranololaction in potentiating quinidine

(dogs), 651beta adrenergic blockade, dos-

age requirements and effectson heart rate and left ventric-

ular performance (calves),394

effects of allylisopropyl-aceta-

mide on disposition and me-tabolism of (dog), 125

hypotensive effects (rats), 219inhibition of deoxycholate-in-

duced secretion of intestinalfluid (dogs), 591

interaction with tetrodotoxinon d V/dtm,.,, of Purkinje fiberaction potentials (dogs), 187

vasodilation, prevention ofplatelet aggregation and neg-ative inotropy, comparisonwith methylthio analog(dogs, rabbits, man), 685

N,N-di-n-Propyl-dopamine, heart

rate lowering effects (rats,dogs), 510

Prostacyclincontribution to preventive ef-

fect of thromboxane synthe-tase inhibitor on coronary ar-terial thrombosis (dogs), 299

inhibition ofrenal vasoconstric-

tion response (dogs), 377

Prostaglandin

blockade, role in renal vasodi-

lator effect of captopnil(dogs), 646

-dependent alpha adrenergic-

mediated renin release(dogs), 321

B2, inhibition of renal vasocon-strictor response (dogs), 377

B2, synthesis stimulated by

bradykinin, inhibition byphosphodiesterase inhibitors

(rabbits), 442

F�,,, analog, effect on gastricemptying and secretion

(monkeys), 287

6-keto-F,,, inhibition by ibu-

profen (man), 415

Protein

binding of phenytoin, effect ofheparin or salicylate acid(rats), 42

plasma, disopyramide binding,influence on kinetics and dy-namics (man), 741

Protein binding, plasma, of war-fans, effects of sulfinpyra-zone and phenylbutazone(man), 691

Protein sites, macnomolecular,bromobenzene epoxidationleading to binding on (rats),563

Purkinje fiberscardiac action potentials, inter-

action of propranolol and tet-

rodotoxin on dV/dt� of(dogs), 187

heart, effect of metabolic inhib-

itors on strophanthidin-in-

duced arrhythmias and con-tracture in (dogs), 75

Pynidine nucleotides, redox stateduring mixed-function oxida-tion in liver (rats), 383

Quenzer, L. F., see Volle, R. L.,338

Quintanilla, A. P., see Gibson, T.P., 54

Quipazine, effect on corticoster-

one secretion (rats), 85

Randall, P. K., Severson, J. A. andFinch, C. B.: Aging and theregulation of striatal dopa-

minergic mechanisms inmice, 695

Rapp, N. S., Zenser, T. V., Mat-tammal, M. B. and Davis, B.B.: Inhibition of bradykininstimulation of renal medal-

lary prostaglandin E2 synthe-sis by phosphodiesterase in-

hibitors, 442

Rating, D., see Nau, H., 768

Rauwolscine, pre- and postsyn-

aptic alpha adrenoceptor se-lectivity studies with (dogs),

540

Ray, J., see Feigen, L. P., 679Receptors

acetylcholine, in skeletal mus-

cle, effect of ketamine (frogs,

rats), 638

-y-aminobutynic acid, mediation

of central cardiovascular ef-

fects of muscimol and homo-taurine by stimulation of(cats), 213

dopamine, brain, regulation

during aging (mice), 695dopamine, heart rate lowering

effects of N,N-di-n-propyl-dopamine via activation of

(rats, dogs), 510

dopamine, in retina (rabbits),701

H and H2, effect of tolazolineand clonidine (guinea pig,rabbits), 474

histamine H2, brain, antago-nism by propantheline andderivatives (guinea pigs), 453

histamine H2, in stomach pan-etal cells, inhibition of gastric

acid secretion (rats), 585-mediated effects, non-beta,

comparative effects of pro-pranolol and methylthio an-

alog (dog, rabbits, man), 685opiate, in ileum, tolerance de-

velopment (guinea pigs), 547

pineal beta, adrenergic, effect of

lithium (rats), 121

presynaptic adenosine, in nicti-

tating membrane, evidenceagainst presence of (cats). 235

sigma, binding of SKF 10,047

(rats, mice), 192

Rech, R. H., see Commissaris, R.L., 170

Reninrelease, alpha adrenergic-me-

diated, prostaglandin-depen-dent (dogs), 321

secretion, effect of brain sero-tonin (rats), 85

Rennick, B., see Besseghir, K., 435Reserpine, effect on [3H]ouabain

binding to smooth muscle vasdeferens (guinea pigs), 163

Respiratory depression, by mor-phine, potency, duration ofaction and pA2 of naloxone inreversal of (man), 156

Retina, modulation of stimula-tion-evoked released of [3H1dopamine in (rabbits), 701

Retinamide, metabolism andbioactivity (rats), 632

Rickert, D. E., see Bond, J. A.,598

Riegelman, S., see Silber, B., 125Riggs, K. W., see Tam, Y. K., 141

Rodgers, R. L., see Simpson, W.W., 231

Roller, P. P., see Swanson, B. N.,632

Rosenfeld, G. C., see Dial, E., 585Rubidium, effects on contractility

and sodium pump activity inventricle (guinea pigs), 573

Rubini, P., see Schultz, R., 547

Ruffolo, R. R., Jr., see Hoffman,B. B., 290

Ruffolo, R. R, Jr., Spradlin, T. A.,Pollock, G. D., Waddell, J. B.and Murphy, P. J.: Alpha andbeta adrenergic effects of thestereoisomers of dobutamine,447

Russell, M. P., Privitera, P. J.,Walle, T., Peet, N. P., Hal-ushka, P. V. and Gaffney, T.E.: Cardiovascular effects ofa 4’-methylthio analog of pro-pranolol, 685

Rutledge, C. 0., see Wince, L. C.,625

Ryanodine, effects on ionic cur-rents and calcium conduct-ance in muscle fibers (crabs),

526

Sagalowsky, A., see Schmitz, J.

M., 400

Saida, K. and Suzuki, A.: Mode of

action of prilocaine on sarco-

plasmic reticulum in skinned

skeletal muscle fibers, 815

Sakai, J., see Noguchi, K., 809Salicylate, effect on oxygen con-

sumption and ventilation,role of cyclooxygenase inhi-

838 Index Vol. 219

bition (dogs), 723Salicylate acid, effect on serum

protein binding and onphenytoin in serum, brain

and cerebrospinal fluid (rats),42

Sanguinetti, M. C. and West, T.C.: Effects of papaverine on

Ca�-dependent action po-tentials in guinea-pig myo-

cardium depolarized by po-

tassium, 715

Saralasin, role in renal vasodilatoreffect of captopril (dogs), 646

Sarcoplasmic reticulum, inskinned skeletal muscle fi-bers, action of prilocaine on(frogs), 815

Sax, R. D. and Westfall, T. C.:

Alterations in prejunctionaladrenoceptor function inguinea-pig and rat vas defer-

ens after chronic ganglionicblockade, 21

Scheurer, U., Drack, B., Varga, L.and Halter, F.: Morphine-likeaction of enkephalin analog

FK 33-824 on motility of theisolated rat colon, 534

Schmidt, R., see Schmitt, S. L.,

407Schmitt, S. L., Taylor, K.,

Schmidt, R., Van Orden, D.

and Williamson, H. B.: Therole of volume depletion, an-tidiuretic hormone and an-

giotensin II in the furose-mide-induced decrease inmesenteric conductance inthe dog, 407

Schmitz, J. M., Graham, R. M.,Sagalowsky, A. and Pettin-

ger, W. A.: Renal alpha-i andalpha-2 adrenergic receptors:Biochemical and pharmaco-logical correlations, 400

Scholtens, B., see Pang, K. S., 134

Schr#{246}r, K., Ohlendorf, R. andDanus, H.: Beneficial effects

of a new carbacyclin deriva-

tive, ZK 36 374, in acute myo-cardial ischemia, 243

Schulz, R., Winter, M., Rubini, P.and Hers, A.: Functional opi-ate receptors in the guinea-

pig ileum: Their differentia-tion by means of selective tol-erance development, 547

Schuster, C. R., see Johanson, C.B., 355

Schwartz, J., see Bousquet, P., 213Secretion

amioride, kidney, electrolyteeffects (chickens), 435

and emptying, gastric, effect ofprostaglandin F2,, analog on

(monkeys), 287

of bile, effect of troleandomycin(rats), 558

of corticosterone, effects of p-chioroamphetamine and qui-pazine (rats), 85

ofgastric acid, inhibition by his-tamine H2 receptor antago-nists (rats), 585

of intestinal fluid, deoxycho-late-induced, inhibition byantidiarrheal drugs (dogs),

591of renin, effect of brain sero-

tonin (rats), 85

ofrenin, effect of phenylephnine

on (dogs), 321

Septal-hippocampal cholinergic

pathwaybrain, interaction between im-

pulse-flow and i�9-tetrahy-

drocannabinol within (rats),580

role in antagonism of pentobar-

bital anesthesia (rats), 489

Serotonin (see also 5-Hydroxy-tryptamine)

brain, role in maintenance ofplasma renin activity (rats),85

effect on sensitized pulmonary

blood vessels (dogs), 551

effect on tolerance to hypnotic

and hypothermic effects ofethanol (mice), 175

systems, brain, relationshipwith taurine-induced hypo-thermia (rabbits), 778

turnover, brain, effects of halo-peridol and butaclamol

(rats), 708

Serum, effect of heparmn or salic-ylate acid on phenytoin in(rats), 42

Severson, J. A., see Randall, P.K., 695

Seyma, I. and Narashi, T.: Mod-ulation of sodium channels ofsquid nerve membrane by

grayanotoxin, 614Sgaragli, G., Carla, V., Magnani,

M. and Galli, A.: Hypother-mia induced in rabbits by in-tracerebroventricular tau-

rine: Specificity and relation-ships with central serotonin(5-HT) systems, 778

Shea-Donohue, P. T., Nompleggi,D. and Dubois, A.: Effect ofa prostaglandin F�,, analog ongastric emptying and secre-tion in rhesus monkeys, 287

Shebuski, R. J., see Aiken, J. W.,299

Shepperson, N. B., Duval, N.,Massingham, R and Langer,S. Z.: Pre- and postsnyaptic

alpha adrenoceptor selectiv-

ity studies with yohimbineand its two diastereoisomersrauwolscine and corynan-thine in the anesthetized dog,540

Shock, electric, effects of chlordi-azepoxide or d-amphetamine

on responding maintainedunder schedules of (mon-

keys), 199Silber, B., Mico, B. A., Ortiz de

Montellano, P. R., Dols, D.M. and Riegelman, S.: In vivoeffects of the cytochrome P-450 suicide substrate 2-iso-propyl-4-pentenamide (allyl-

isopropylacetamide) on thedisposition and metabolic

pattern of propranolol, 125Simpson, W. W., Rodgers, R. L.

and McNeil, J. H.: Cardiac

responsiveness to alpha andbeta adrenergic amines: Ef-

fects of carbachol and hypo-

thyroidism, 231Sinclair, R., see Yorio, T., 459

Singh, D. K., see Yarbrough, G.G., 604

SKF 10,047, sigma opiate, bindingand analgesic properties(rats, mice), 192

Skin, sodium transport site

(frogs), 481Smith, A. L., see Koup, J. R., 316Smith, B. R., see Steele, J. W., 35

Smooth muscle (see Muscle,

smooth)Sodium

cellular content of aortic

smooth muscle, long-term ef-fects of captopril on (rats),

520reabsorption in renal tubule, ef-

fect of ethacrynic acid (dogs),505

transport in skin, effect of ami-locale (frogs), 481

Sodium channelbinding, interaction of propran-

olol and tetrodotoxin (dogs),187

Sodium channel

of giant axons, modulation bygrayanotoxin (squid), 614

tetramethnn modification, ki-netics of (squid), 464

Sodium ions, effect on SKF 10,047

binding (rats, mice), 192Sodium-potassium pump, in-

volvement in postjunctionalsupersensitivity of smooth

muscle vas deferens as as-sessed by [3H]ouabain bind-

ing (guinea pigs), 163

Sodium pump, activity, in ventri-

cle, effect ofrubidium (guinea

pigs), 573

Sodium sulfate, effect on acet-aminophen elimination Id-netics (rats), 14

Spiegel, K., see Pasternak, G. W.,

192Spinal cord

adenosine regulation of cyclicAMP formation in (rats), 370

taurine and effects of fl-alanine(toad), 604

[‘H]Spiroperidol binding, inbrain, effects of halopendol

and butaclamol (rats), 708

Spleen, perfused, effect of guani-dine derivative on norepi-

nephrine release in (cats), 748Sporn, M. B., see Swanson, B. N.,

632Spradiin, T. A., see Ruffolo, R. R.,

Jr., 447

Steele, J. W., Yagen, B., Hernan-dez, 0., Cox, R. H., Smith, B.R. and Bend, J. R.: The me-tabolism and excretion of sty-

rene oxide-glutathione con-

jugates in the rat and by iso-lated perfused liver, lung and

kidney preparations, 35Steen, P. A., Hartmann, A. and

Kiil, F.: Ethacrynic acid in-hibits transcellular NaC1reabsorption in dog kidneysin doses of 1 to 10 mg. kg’

and proximal bicarbonate-de-pendent reabsorption at

higher doses, 505

Stephens, N. L., see Kong, S-K.,551

Sterling, K. M., Jr., see Counts, D.F., 675

Stimulationbradykinin, of renal medullary

prostaglandin synthesis, in-hibition by phosphodiester-

ase inhibitors (rabbits), 442

of adenylate cyclase of atria by

catecholamines (rats), 625of renal nerves, effect of arachi-

donic acid on vasoconstrictor

response elicited by (dogs),

377

Stolerman, I. P., see D’Mello, G.

D., 60

Stomach

emptying and secretion, effect

of prostaglandin F2,, analogon (monkeys), 287

histamine response and phar-macology in isolated parietalcells in (rats), 585

Stress, decapitation, effect on ac-

tivation of tyrosine hydroxy-lase in portal vein (rabbits),97

Strong, J. M., see McManus, M.B., 669

Strychnine, effect on taurine-in-

duced hypothermia (rabbits),778

Styrene oxide-glutathione conju-gates, metabolism and excre-tion (rats), 35

Suicide substrates, destruction ofcytochrome P-450 by allyli-sopropylacetamide (dog), 125

Sulfate conjugationacetaminophen, kinetics of for-

mation (rats), 14of harmol, kinetics of (rats), 134

Sulfinpyrazone

and phenylbutazone, compara-tive interaction with racemicwarfarin (man), 691

effect on adrenochrome-in-duced coronary artery con-striction in heart (rats), 225

5- and R-Sulpiride, effect on stim-ulation-evoked release of

[3H}dopamine in retina (rab-bits), 701

Suis#{233},H. and Malik, K. U.: Atten-

uation by arachidonic acid ofthe effect of vasoconstrictorstimuli in the canine kidney,377

Suzuki, A., see Saida, K., 815Swanson, B. N., Newton, D. L.,

Roller, P. P. and Sporn, M.

B.: Biotransformation and bi-

1981 Index 839

ological activity of N-(4-hy-droxyphenyl) retinamide de-

rivatives in rodents, 632

Tabakoff, B., see Melchior, C. L.,175

Takimoto, G. S. and Weiner, N.:Effects of nitroprusside-in-

duced hypotension on sym-pathetic nerve activity, tyro-

sine hydroxylase activity and[:IH1norepinep�.�e uptakein rabbit vascular tissues, 420

Taste aversions, conditioned, ef-fects of cocaine, apomor-

phine, diisobutyrylapomor-

phine and Win 35,428 (rats),60

Taurinebrain, induced hypothermia, re-

lationship with serotonin sys-tems (rabbits), 778

brain, neuropharmacologicalcharacterization of antago-nist (rats), 604

central cardiovascular effects,comparison with homotau-nine and muscimol (cats), 213

Taylor, D. A., see Yarbrough, G.G., 604

Taylor, K., see Schmitt, S. L., 407

Takimoto, G. S. and Weiner, N.:

Evidence for the transsynap-tic activation of tyrosine hy-droxylase in rabbit portalvein mediated through acyclic AMP-independent

mechanism, 97Tam, Y. K., Axelson, J. B., Mc-

Erlane, B., Kapil, R. P.,Riggs, K. W., Ongley, R. andPrice, J. D. E.: The pharma-cokinetics of metoclopramide

in rats with experimentalrenal and hepatic dysfunc-tion, 141

Tension, development, in intralo-bar pulmonary arteries andveins, effect of prostacyclinand 9a,1 la-epoxymethano-prostaglandin H2 on (dogs),326

�9-Tetrahydrocannabinol, withinseptal-hippocampal cholin-

ergic pathway of brain, inter-action with impulse-flow(rats), 580

Tetramethnn, kinetics of sodium

channel modification in giantaxon by (squid), 464

Tetrodotoxineffect on contractile responses

of thoracic aorta and pulmo-nary arteries (rabbits), 792

interaction with propranolol ondV/dtma, ofPurkinje fiber ac-tion potentials (dogs), 187

Theophylline, effect on stimula-tion-evoked norepinephrine

in nictitating membrane(cats), 235

Thompson, W. J., see Dial, B., 585Thoolen, M. J. M. C., Timmer-

mans, P. P. B. M. W. M. andvan Zwieten, P. A.: The influ-

ence of continuous infusionand sudden withdrawal ofazepexole (B-HT 933) onblood pressure and heart ratein the spontaneously hyper-tensive and normotensive rat.Suppression of the with-drawal responses by mor-phine, 786

Thromboxane A2, inhibitory ef-fects of aspirin and ibuprofenon production (man), 415

Thurman, R. G., see Danis, M.,

383

Thymus lymphocytes, mitogenicstimulation, inhibition ofamino acid transport by anti-inflammatory drugs during(rats), 752

Thyroid hormone, action on myo-

cardial beta adrenergic recep-tors (calves), 394

Thyrotoxicosis, beta adrenergicblockade with propranolol in(calves), 394

Thyrotropin-releasing hormone,effect on metabolism of ace-tylcholine (rats), 489

Timmermans, P. P. B. M. W. M.,see Thoolen, M. J. M. C., 786

Timmermans, P. B. MW. M., see

van Meel, J. C. A., 760

Tissue levels, of acetaminophen

and its metabolites after toxicdose (mice), 281

Tissues, vascular, effects of nitro-prusside-induced hypoten-

sion on sympathetic nerve ac-

tivity, tyrosine hydroxylase

activity and [‘H]norepineph-rine in (rabbits), 420

Tokumura, A., Kume, T., Fuku-zawa, K. and Tsukatani, H.:Cardiovascular effects of ly-sophosphatidic acid and its

structural analogs in rats, 219

Tolazoline, histamine-like effects(guinea pigs, rabbits), 474

Tolerance

development in opiate recep-

tors in ileum (guinea pigs),547

to hypnotic and hypothermiceffects of ethanol (mice), 175

to morphine and enkephalins(rats), 344

to morphine at choledochodu-odenal junction (dogs), 274

to morphine, involvement ofdynorphin (mice), 296

to i�9-tetrahydrocannabinol(mice, rats, dogs), 363

Tomoike, H., see Noguchi, K., 809

Toxicity, of acetaminophen, role

of drug metabolism (mice),281

Transmissionadrenergic, effect of guanidine

derivatives on (cats), 748

ganglionic, role of cyclic GMP(rats), 338

neuromuscular, in mctitatingmembrane, effects of adeno-sine (cats), 235

neuromuscular, in skeletal mus-

cle, effect of ketamine (frogs,

rats), 638

Transport

of p-aminohippurate in renal

tissue, heavy metal inhibition

(fish), 428renal tubule, of amioride, elec-

trolyte effects (chickens), 435

renal tubular, oftyrosine, struc-tural specificity (dogs), 69

Trapidil, coronary dilating effects

(dogs), 809

Trypsin, effect on SKF 10,047

binding (rats, mice), 192Tsukatani, H., see Tokumura, A.,

219Tulunay, F. C., Jen, M.-F., Chang,

J.-K., Loh, H. H. and Lee, N.M.: Possible regulatory roleof dynorphin on morphine-

and fl-endorphin-induced an-

algesia, 296

Tyrosine, renal tubular transport,

structural specificity (dogs),69

Tyrosine hydroxylase

activity in vascular tissues, ef-

fects of nitroprusside-in-duced hypotension on (nab-

bits), 420

in portal vein, transsynaptic ac-tivation of (rabbits), 97

UK-14,304, selectivity for periph-eral alpha-i and alpha-2 ad-renoceptors (rats), 760

Uptake

45Ca, and cyclic GMP accumu-lation in ganglion, effect of

preganglionic nerve stimula-

tion (rats), 338choline, sodium-dependent,

high affmity, brain, effect of

�9 - tetrahydrocannabinol

(rats), 580[�]norepinephrine in vascular

tissues, effects ofnitroprusside-induced hypo-tension (rabbits), 420

of p-aminohippurate, effect ofouabain (fish), 428

Urakawa, N., see Ito, K., 520Urate, blood, reduction with

polyethylene glycol-uricase

(cockerels, rats), 352

Uricase, polyethylene glycol, re-duction of plasma urate

levels with (cockerels, rats),352

Urinary tract, nitroreductase ac-tivity (rabbits), 735

Uterus, mediation of myometrialcontraction and regulation byestrogens of alpha adrenergicreceptor subtypes in (rab-

bits), 290

Valentine, J. 0., see Barrett, J. B.,199

Valproic acid, placental transfer,neonatal pharmacokinetics,transfer via mother’s milk

and clinical status in neo-nates of epileptic mothers

(man), 768

Van De Kar, L. D., Wilkinson, C.W. and Ganong, W. F.: Phar-macological evidence for a

role of brain serotonin in themaintenance of plasma reninactivity in unanesthetized

rats, 85

van Meel, J. C. A., de Jonge, A.,

Timmermans, P. B. M. W. M.and van Zwieten, P. A.: Selec-tivity of some alpha adreno-

ceptor agonists for peripheralalpha-i and alpha-2 adreno-

ceptors in the normotensive

rat, 760Van Orden, D., see Schmitt, S. L.,

407

van Zwieten, P. A., see van Meel,

J.C.A., 760van Zwieten, P. A., see Thoolen,

M.J.M.C.,786

Varga, L., see Scheurer, U., 534

Vascular bedmesenteric, effects of indo-

methacin and ibuprofen on

vasodilator response to ara-

chidonate in (dogs), 679

renal, effect of arachidonic acid

(dogs), 377Vas deferens

alterations in prejunctional ad-renoceptor function after

ganglionic blockade (guineapigs, rats), 21

smooth muscle, Na-K pump

sites, binding of [‘H]ouabainto (guinea pigs), 163

Vasoconstrictioneffects of alpha-i and alpha-2

adrenoceptors (rats), 760mesenteric, effect of indometh-

acm and ibuprofen (dogs),679

renal, effect of alpha-i and al-pha-2 adrenergic receptors

(rats), 400

Vasoconstrictor response, renal,

effect of arachidonic acid on

(dogs), 377Vasodilation

coronary, induced by trapidil,

nitroglycerin and dipynida-

mole (dogs), 809

renal, captopril-induced (dogs),646

Vassalle, M., see Bhattacharyya,M. L., 75

Veinsportal, transsynaptic activation

of tyrosine hydroxylase in

(rabbits), 97

pulmonary, intralobar, effect ofprostcyclin and 9a, 1 la-epox-

ymethanopnostaglandin H2on calcium and magnesiumfluxes and tension develop-ment in (dogs), 326

Ventilation, role of cyclooxygen-

ase inhibition in stimulation

of (dogs), 723Verapamil

effect on adrenochrome-in-duced coronary artery con-

striction in heart (rats), 225inhibition of deoxycholate-in-

121

840 Index Vol. 219

duced secretion of intestinal

fluid (dogs), 591VoIle, R. L., Quenzer, L. F., Pat-

terson, B. A., Alkadhi, K. A.and Henderson, B. G.: Cyclicguanosine 3’:S’-monophos-phate accumulation and Ca-uptake by rat superior cervi-cal ganglia during pregan-glionic stimulation, 338

Volume expansion, effect on renal

clearance of digoxin (dogs),54

Waddell, J. B., see Ruffolo, R. R.,

Jr., 447

Walle, T., see Russell, M. P., 685

Warfanin, racemic, comparative

interaction of sulfmpyrazoneand phenylbutazone with

(man), 691

Warnick, J. B., see Maleque, M.

A., 638Watthey, J. W. H., see Benos, D.

J., 481Weber, A., see Koup, J. R., 316Wein, A. J., see Levin, R. M., 250Weiner, N., see Dubocovich, M.

L., 701

Weiner, N., see Takimoto, D. S.,

97, 420West, T.C., see Sanguinetti, M. C.,

715Westfall, D. P., see Wong, S. K.,

163Westfall, T. C., see Sax, R D., 21

White, R., see McManus, M. B.,669

Wilkinson, C. W., see Van De Ka,L. D., 85

Williams, W. M. and Huang, K.C.: Structural specificity inthe renal tubular transport oftyrosine, 69

Williamson, H.E., see Schmitt, S.

L., 407Win, 35,428, effect on conditioned

taste aversion and schedule-controlled behavior (rats), 60

Wince, L. C. and Rutledge, C. 0.:The effect of dietary lipid onthe binding of[3H)dihydroal-

prenolol and adenylate cy-

clase activity in rat atria, 625Withdrawal

acute, from morphine at chole-dochoduodenal junction(dogs), 274

from azepexole, effects of mor-

phine (rats), 786

Wong, P. C., Zimmerman, B. G.,Kraft, B., Kounenis, G. and

Friedman, P.: Pharmacologi-

cal evaluation in consciousdogs of factors involved in therenal vasodilator effect of

captopril, 646

Wong, S. K., Westfail, D. P., Fe-dan, J. S. and Fleming, W.W.: The involvement of thesodium-potassium pump in

postjunctional supersensitiv-ity of the guinea-pig vas def-erens as assessed by [3H]oua-

bain binding, 163

Wdster, M., see Schultz, R., 547

Yagen, B., see Steele, J. W., 35Yang, W. C. T., see Muakkasah,

S. F., 147

Yarbrough, G. G., Singh, D. K.and Taylor, D. A.: Neuro-

pharmacological characteri-zation ofa taurine antagonist,

604Yocca, F. D., see Friedman, B.,

Yohimbine, pre- and postsynapticalpha adrenoceptor selectiv-

ity studies with (dogs), 540Yorgey, K. A., see O’Neill, P. J.,

665Yorio, T., Sinclair, R. and Henry,

S.: Fluoride inhibition of thehydro-osmotic response of

the toad urinary bladder to

antidiuretic hormone, 459

Zannoni, V. G., see Lau, S. S., 563Zenser, T. V., Mattammal, M. B.,

Palmier, M. 0. and Davis, B.B.: Microsomal nitroreduc-tase activity of rabbit kidneyand bladder: Implications in5-nitrofuran-induced toxic-

ity, 735

Zenser, T. V., see Rapp, N. S., 442

Zimmerman, B. G., see Wong, P.C., 646

ZK 36,374, effects in myocardial

ischemia (cats), 243

Zomepirac, pharmacokinetics andrenal handling (monkeys),665