787

INDEX

Volume 222, July-September, 1982

Abe, Y., see Miura, K., 246Abiko, Y., see Ichihara, K., 720

Abraham, D. J., see Fisher, A.,140

Abramson, F. P., see Bai, S. A.,589

Acetaminophen, formation fromphenacetin and acetanilideon sulfation kinetics in per-fused liver (rats), 14

Acetanilide, deuterated and non-deuterated, role in formationofacetaminophen in perfusedliver (rats), 14

Acetylcholine

antinociception, mediation byopiate receptors via therelease of morphine-like ma-terials (mice, guinea pigs),612

effect on norepinephrinerelease in cerebral arteries(cats, rabbits), 562

effects on cyclic AMP levels inheart (chicks), 383

endothelium-dependent effects

in femoral artery (dogs), 166in brain, effect of clonidine on

physostigmine-induced in-creases of (mice), 595

in brain, effect of ethylcholinemustard aziridiniam ion on(mice), 140

metabolism, during hypoxia, ef-fect of 3,4-diaminopyridine

on (mice), 576synthesis and release in term

placenta, effect of cholineacetyltransferase on (man),301

turnover rate in brain, effects ofadenosine analogs and theo-

phylline on (rats), 550Acetylcholine release, influence of

glycosidic conformation on

activity of ademne nucleo-sides as presynaptic inhibi-

tors of (guinea pigs), 241

inhibition by streptomycin

(frogs), 488Adenine nucleosides, presynaptic

inhibitors of acetyicholine

release, influence of glyco-siclic conformation andcharge distribution on(guinea pigs), 241

Adenosinepresynaptic inhibition of acetyl-

choline release by (guinea

pigs), 241

-uptake blockade by benzodi-

azepines (guinea pigs), 752Adenosine triphosphate, endothe-

lium-dependent effects infemoral artery (dogs), 166

Na�,K�-Adenosine triphospha-tase, inhibition by vanadate(dogs), 447

Adenylate cyclase, development

in heart (mice), 7Adrenergic receptor, beta, devel-

opment in heart (mice), 7

Adrenergic receptors, alpha-i

and alpha-2, interactions of

imidazolines (guinea pigs), 29Adrenoceptors

alpha adrenergic, effects in-

duced by clomdine-like imi-dazolidines (rats), 705, 712

alpha-i, antagonism of ketan-serin by (rats), 227

beta, role in renin release(dogs), 606

beta, -stimulated renin release,

effects of indomethacin

(dogs), 414

Aerice, M. T., see Talbot, P. A.,87

Aflatoxin B1, effect on hepaticphase I and II transformation(rats), 471

Aghajanian, G. K., see Marwaha,J., 287

Agonistsalpha adrenoceptor, role in me-

diating sleep-like behavior(chicks, rats), 680

delta opiate, modulation of do-pamine release in striatalslices by (rats), 435

Agonists-antagonists, adrenergic,

effects on phosphatidylinosi-tol labeling and contraction

in aorta (rabbits), 258Akera, T., see Takeda, K., 132

Albuterol, stimulation of reninrelease by (dogs), 606

Alcohol dehydrogenase-depend-ent metabolism of ethanol,

role of testosterone (rats), 20Allyl alcohol, effect on hepatic

phase I and II transformation(rats), 471

Alpha-i glyprotein, induction byphenobarbital (dogs), 589

-y-Aminobutyric acid, transmis-

sion in medullary depressorregion (cats), 517

Aminophylline, antagonism of 2-chloroadenosine renal effects

by (rats), 319

Aminoquinolines, interaction

with presynaptically acting

neurotoxins (mice, rats,

guinea pigs, chicks), 43

Aminoxyacetic acideffect on dopamine metabolism

in nigrostriatal pathway(rats), 674

role in elevation of y-aminobu-

tyriclevels in brain (cats), 517

Amitriptyline

effect on fixed-interval re-spending (squirrel monkeys),215

-induced toxicity, action of di-azepam and sympathomi-metic amines against (cats),

424suppression of histamine-in-

duced adrenocorticotropichormone release by (rats),583

2’-AMP, effect on mtrofurantoin-

mediated depletion ofred cellreduced glutathione (man),430

Amphetamine, potentiation ofketamine-induced loss ofrighting reflex and sleepingtime (mice), 122

d-Amphetaminebehavioral and cross-tolerance

to (rats), 126

self administration, behavioraleffects (dogs), 52

Amygdala-kindled seizures, effecton [3H]quinuciclinyl benzi-

late binding sites (rats), 670

Analgesiamorphine and enkephalins, ef-

fect of naloxone (rats), 190tail-flick, effect of buprenor-

phine on opiate receptorsduring (rats), 198

Analogof prostaglandin, renal vasodi-

latory activities of (dogs,

rats), 152prostaglandin endoperoxide, ef-

fect on gastric emptying andsecretion (monkeys), 379

Analogs, of $-endorphine, role in

modification of $-endorphin(rats), 262

Anderson, W., Molina, E., Rentz,J. and Hirschowitz, B. I.:Analysis of the 2-deoxy-D-

glucose-induced vagal stimu-

lation of gastric secretion andgastrin release in dogs using

methionine-enkephalin, mor-phine and naloxone, 617

Antagonists

alpha adrenoceptor, inhibition

of sleep time induced by al-pha adrenoceptor agonists(chicks, rats), 680

alpha-i and alpha-2, effects onlocus ceruleus, dorsal rapheand dorsal lateral gemculatenuclei (rats), 287

calcium, effects on coronarycollateral blood flow (dogs),494

calcium, effects on isotropic ac-tion of vanadate in isOlatedheart (rats, guinea pigs), 132

Antidepressant-induced corneal lesions (rats),

282-induced decline in beta adre-

nergic and serotomn2 recep-tor binding in brain, effects ofadrenocorticotropic hormone

and yohimbine (rats), 566Antonaccio, M. J., see Taylor, D.

G., 517

Aorta

effect of alpha-i adrenergic re-ceptor on phosphatidylinosi-tel labeling and contractionin (rabbits), 258

evaluation of alpha-i adrener-gic effects of cirazoline in(guinea pigs), 29

Aprotinin, inhibition of hypoten-sive action of SQ 14,225 by(dogs), 246

1-fl-D-Arabinofuranosylcytosine,liposome-encapsulated andfree, distribution and metab-olism of (dogs, mice), 324

Arachidonate, toxicity, sexual dii-ferentiation of (mice), 315

Arachidonic acidendothelium-dependent effects

in femoral artery (dogs), 166mobilization, effects of diuretics

on (rats), 306Argentieri, T. M., see D’Alonzo,

A. J., 401Arteries, cerebral, effect of acetyl-

choline on norepinephrinerelease in (cats, rabbits), 562

Artery

coronary, effect of propranololon stenosis severity in (dogs),635

ear, contractility induced byserotonin masks desensitiza-

tion to norepinephrine in(rabbits), 338

femoral, endothelium-depend-

ent effects of acetylcholine,adenosine triphosphate,thrombin and arachidomcacid (dogs), 166

mesenteric, role of nucleosidesand nucleotides in neuromus-cular transmission in (rats),344

radial, termination of responses

to sympathetic nerve stimu-

lation and to noradrenaline,effects of cocaine and 17-/i-

estradiol (cows), 731Artery constriction, renal, effect

on prostaglandin 12 biosyn-thesis and renin release

788 Index

(dogs), 410Artery occlusion, coronary, effects

of diltiazem and propranolol

(dogs), 720Ashizawa, H., see Takahashi, H.,

726

Aspirin, effect on carbon tetra-chloride-induced elevation ofangiotensin converting en-zyme levels (mice), 641

Astroglia, cerebral cortical, iden-tification of beta adrenergicreceptor subtype on (rats),600

Atropineantagonism of gastrointestinal

activity (rabbits), 66effect on fixed-interval re-

spending (squirrel monkeys),215

effect on histamine-inducedarousal (rats), 37

13-Azaprostanoic acid-induced

platelet shape change (man),276

Bai, S. A. and Abramson, F. P.:

Interactions of phenobarbital

with propranolol in the dog.1. Plasma protein binding,589

Barnes, G. A., see Slotkin, T. A.,

741, 746

Bartolome, J., see Slotkin, T. A.,

741, 746

Behaviorcomparison of morphine and

enkephalins, use of tail-flicktest in (rats), 190

effect of buprenorphine on opi-ate receptors in tail-flick test

(rats), 198effect of dt-cathinone and d-

amphetamine on milk intake

(rats), 126effect of3,4-diaminopyridine on

tight rope test scores duringhypoxia (mice), 576

fixed-interval responding, ef-fects of tricycic antidepres-sent and anticholinergicdrugs on (squirrel monkeys),215

histamine-induced arousal(rats), 37

phencycidine-like discrimina-

tive stimulus properties ofnarcotic derivatives (rats),

146postnatal maternal, effects of

ethanol and t-butanol diet on(mice), 294

self-administration of f1-phen-ylethylamine, N-methylphen-ylethylamine, d-amphet-amine and phenylethanola-mine (dogs), 52

Benabe, J. E., see Nova, J. M. L.,447

Benzalkonium chloride, inhibitionof histamine release (rats),

652Benzodiazepines, potentiation of

cardiac responses to adeno-sine by (guinea-pigs), 752

Benzyldimethyltetradecylam-

monium Cl, inhibition of his-ta.mine release (rats), 652

Bepridil, effect on Ca�-depend-ent slow action potentials inskeletal muscle (frogs), 80

Best, K. L., see Wong, D. T., 61

Bevan, J. A., see Rapoport, R M.,338

Bicuculline, effect on ‘y-aminobu-tyric acid transmission (cats),517

Billingsley, M. L. and Mandel, H.G.: Effects of DNA synthesis

inhibitors on post-traumaticglial cell proliferation, 765

Bindingof gallamine to plasma proteins

(dogs), 389of propranolol, induction by

phenobarbital (dogs), 589Binding site

of aminoglycosides (rats), 350opiate, on dopamine neurons

(molluscs), 759

Binding sitesof opiates (rats, cows, man,

chickens, toads), 629quinucidinyl benzilate, in den-

tate gyms, effect of kindled

seizures on (rats), 670

Biotransformation pathways,phase II, resistance to hepa-totoxins (rats), 471

Blame, E. H., Russo, H. F.,

Schorn, T. W. and Snyder,C.: An orally active prosta-glandin analog with renal Va-

sodilatory activity in the dog,152

Blaker, W. D., see Murray, T. F.,550

Block, E. M., see Vonvoigtlander,

P. F., 282Blood cells, red, thiopurine meth-

yltransferase activity in

(man), 174Blood flow

coronary, collateral, effects ofcalcium antagonists on(dogs), 494

myocardial, effect of proprano-lol on (dogs), 635

pancreatic, effect of prostaglan-din.s on (dogs), 623

regional, effect of diltiazem on(rats), 359

renal, effect of prostaglandinanalog (dogs, rats), 152

Blood pressureeffect of conjugated estrogens

(rats), 726effect of ketanserin on (rats),

227

effect oflabile hydrazones (rats,rabbits), 159

involvement of serotonin in

control of (cats), 94Blumberg, A., see Lukacsko, P.,

344

Botulinum toxin, effect of chloro-quine (mice, rats, guinea pigs,chicks), 43

Brady, L. S. and Holtzman, S. G.:Analgesic effects of intraven-tricular morphine and en-kephalins in nondependent

and morphine-dependent

rats, 190

Brain (see also specific part)alpha-i and alpha-2 adreno-

ceptors, electrophysiologicalstudy (rats), 287

cerebral cortex mince, propran-olol effect on lipids (rats), 109

development of norepinephrineand dopamine in (rats), 746

development of ornithine de-carboxylase and polyamines

in (rats), 741

effect of citalopram on inhibi-tion by lysergic acid diethyl-amide of serotonin releasefrom (rats), 220

effect of clonidine on physostig-mine-induced increases ofacetyicholine in (mice), 595

effect of conjugated estrogenson renin-angiotensin systemin (rats), 726

effect of ethanol on opiate re-ceptors in (mice), 182

effect of ethylcholine mustardaziridinium ion on acetylcho-

line, choline acetyltransfer-

am and choline transport in(mice), 140

effects of adenosine analogs andtheophylline on acetylcholineturnover rate in (rats), 550

frontal cortex, influence of ad-renocorticotropic hormoneand yohimbine on antide-pressant-induced decline inneurotransmitter receptor

binding in (rats), 566identification of beta adrenergic

receptor subtype on astrogliapurified from (rats), 600

inhibition by pentobarbital ofcholine uptake in (rats), 778

inhibition of norepinephrineuptake by LY135252 in (rats),61

involvement of alpha noradre-

nergic receptors in mediationof polyphosphoinositide me-

tabolism in (rats), 209mesencephalic reticular forma-

tion, effects of phentolamineand propranolol on norepi-nephrine-evoked neuronal

firing in (rats), 555

solubilization and characteriza-tion of opiate binding sites

from (rats, cows, man, chick-ens, toads), 629

striatum, modulation of dopa-

mine release by delta opiateagonists in (rats), 435

transmission of y-aminobutyricacid in (cats), 517

transplant of cerebellum, sen-sitivity of Purkinje cells to

depressant effects of ethanolin (mice), 480

Branch, R A., see Jackson, E. K.,410, 414

Bromobenzene, effect on hepatic

phase I and II transformation(rats), 471

Bronchoconstriction, leukotriene-

induced in vitro and in vivo,

Vol. 222

effects of indomethacin andmeclofenamic acid (guinea

pigs), 202Brooks, H. L, see Zyvoloski, M.

G., 494Brunswick, D. J., see Heydorn, W.

E., 534Brusiow, S., see Mitch, W. E., 572Buccafusco, J. J.: Mechanism of

the clonidine-induced protec-tion against acetylcholines-terase inhibitor toxicity, 595

Buck, J. D., see Gross, G. J., 635Buprenorphine, effect on opiate

binding (rats), 198t-Butanol, maternal diet, compar-

ison with maternal ethanoldiet on postnatal develop-ment (mice), 294

Bymaster, F. P., see Wong, D. T.,61

Ca�-dependent slow action po-tentials in skeletal muscle, ef-fects of bepridil and verapa-mil on (frogs), 80

Cadmium, chelation from metal-

lothionein after injection ofcadmium chloride (rats), 699

Cadmium chloride, effect on he-patic phase I and II transfor-mation (rats), 471

Caill#{233},G., see Lambert, C., 232Calcium channel blockers

effects on cardiac output distri-bution (rats), 359

effects on renal renin secretion(dogs), 447

Calcium pools, involvement incontractile activation in iso-lated heart, effect of vana-date (rats, guinea pigs), 132

CaImOdUIin, inhibition by pheno-thiazines (rats), 509

Carbon, C., see Nivoche, Y., 237Carbon tetrachloride

effect on angiotensin convertingenzyme levels in lung (mice),

641effect on hepatic phase I and II

transformation (rats), 471

Cardiovascular dynamics, effectof diltiazem on (rats), 359

Carino, M. A., see Horita, A., 367

Casey, L C., Fletcher, J. R.,Zmudka, M. I. and Ramwell,P. W.: Prevention of endo-

toxin-induced pulmonary by-pertension in primates by theuse of a selective thrombox-ane synthetase inhibitor,Oxy 1581,441

Castration, effect on alcohol de-hydrogenase-dependent me-

tabolism of ethanol (rats), 20Catechola.mines, developmental

effects of a-difluoromethylor-nithine on (rats), 746

dl-Cathinone, behavioral andcross-tolerance to (rats), 126

Caturay, E. M., see Huidobro-

Tore, J. P., 262Cavero, I., see Roach, A. G., 680

Cell, glial, effects of DNA synthe-sin inhibitors on post-trau-matic proliferation of (rats),

1982 Index 789

765

Cellsendothelial, in lung, injury after

carbon tetrachloride admin-istration (mice), 641

Purkinje, sensitivity to ethanol(mice), 480

red, studies on nitrofurantoin-mediated depletion of re-

duced glutathione in (man),430

Cerebellar grafts, ethanol sensi-

tivity of (mice), 480Cerebellum, transplant, sensitiv-

ity of Purkinje cells to de-pressant effects of ethanol in(mice), 480

Chan, C.-C. and Kaisner, S.: Ter-mination of responses to

sympathetic nerve stimula-tion and to noradrenaline ina perfused arterial prepara-tion: The role ofneuronal andextraneuronal uptake, 731

Chan, K. K., see Pang, K. S., 14Chandra, A., see Liii, M. T., 251Chassaing, C., Duchene-Marullaz,

P. and Paire, M.: Mechanismof action of quinidine onheart rate in the dog, 688

Chau, T. T., Izazola-Conde, C. andDewey, W. L.: Evidence forthe existence of peptide andnonpeptide morphine-likematerials in mouse brain: Ef-fect of an analgesic intracere-broventricular dose of acetyl-choline on their levels, 612

Chaung, L.-Y., see Wolf, R. A.,331

Chelation, of cadmium from me-tallothionein (rats), 699

Chen, F.-C. M., Yamamura, H. I.and Roeske, W. R.: Adenyl-ate cyclase and beta adrener-gic receptor development inthe mouse heart, 7

Cheney, D. L., see Murray, T. F.,550

Chloramphemcol, effect on di-uretic response to furosemide(rats), 232

Chiorisnipramine, effect on fixed-interval responding (squirrelmonkeys), 215

2-Chloroadenosine

antagonism by aminoadenosineon renal effects of (rats), 319

effect on adenosine turnoverrate in brain (rats), 550

2-Chloropropionate, metabolicand toxic effects, comparisonwith dichloroacetate (rats,mice), 501

Chloroquine, effects on botulinumand tetanus toxin (mice, rats,guinea pigs, chicks), 43

Chlorpheniramine, effect on his-tamine-induced adrenocorti-

cotropic hormone release

(rats), 583Choline acetyltransferase

in brain, effects of ethylcholinemustard aziridinium ion on(mice), 140

inhibition, effect on acetylcho-

line synthesis and release interm placenta (man), 301

Cherian, M. G. and Rodgers, K.:

Chelation of cadmium from

metallothionein in vivo andits excretion in rats repeat-

edly injected with cadmiumchloride, 699

Chesselet, M. F., see Lubetzki, C.,435

Chromonar, maximal vasodilation

by (dogs), 635Churchill, P. C.: Renal effects of

2-chloroadenosine and theirantagonism by aminophyl-line in anesthetized rats, 319

Cicero, T. J., Newman, K. S.,Schmoeker, P. F. and Meyer,

E. R.: Role of testosterone inethanol and morphine-in-duced increases in the alcoholdehydrogenase -dependentmetabolism of ethanol in themale rat, 20

Cimetidine, effect on histamine-

induced arousal (rats), 37Cinanserin, inhibition of sympa-

thetic nervous discharge(cats), 94

Cirazoline, alpha-i and alpha-2

adrenergic effects of (guineapigs), 29

Cita.lopram, effect on inhibition of

serotonin release by lysergicacid diethylamide (rats), 220

Claeys, M., see De Mey, J. G., 166Clark, M. J., see Leventer, S. M.,

301Clearance, renal, of digoxin, effect

of quinidine (dogs), 49

Clementi, W. A., McNay, J. L.,Talseth, T., Haegele, K. D.,Ludden, T. M. and Musgrave,G. E.: Endogenous genera-tion of hydralazine from la-bile hydralazine hydrazones.

159Clohisy, D. R., Quintanilla, A. P.

and Gibson, T. P.: Effect ofquinidine on the renal clear-ance of digoxin in the pres-ence of low and high serumdigoxin concentrations, 49

Clonidinebradycardic activities (rats),

712

central and peripheral hypoten-sive activity (rats), 705

-induced sleep time, inhibition

by alpha-2 adrenoceptor an-tagonists (chicks, rats), 680

inhibition of phrenic nerve ac-tivity by (cats), 771

protective effects on physostig-

mine-induced toxicity (mice),595

Cocaine

effect on sympathetic nerve

stimulation and noradrena-line concentration in radialartery (cows), 731

potentiation of ketamine-in-

duced loss of righting reflex

and sleeping time (mice), 122Conanan, L B., see Crutchley, D.

J., 544

Conformation, glycoside, influ-

ence on activity of ademne

nucleosides as presynaptic in-

hibitors of acetylcholinerelease (guinea pigs), 241

Contractile activation, in isolatedheart, involvement of cal-cium pools, effects of vana-

� date (rats, guinea pigs), 132

Contractilityin ear artery, masks desensiti-

zation to norepinephrine

(rabbits), 338myocardial, effects of strepto-

zotocin diabetes and insulin

treatment on (rats), 395

Contractions, of aortic strips, ef-fect of alpha-i adrenergic re-ceptor on (rabbits), 258

Contrepois, A., see Nivoche, Y.,237

Cook, M. A., see Paul, M. L., 24i

Corynanthine, effect on clomdine-induced sleeping time(chicks, rats), 680

Costa, E., see Murray, T. F., 550

Cowan, A., see Tallarida, R. J.,198

Craven, P. A. and DeRubertis, F.R.: Calcium-dependent stirs-ulation of renal medullaryprostaglandin synthesis by

furosemide, 306Cremieux, A.-C., see Nivoche, Y.,

237

Crutchley, D. J., Conanan, L. B.and Maynard, J. R.: Stimu-lation of fibrinolytic activity

in human skin fibroblasts byprostaglandins E1, E� and 12,

544

Cruz-Soto, M. A., see Nova, J. M.

L., 447Cyclic AMP, accumulation in

heart, effects of cholinergic

muscarinic agonists on

(chicks), 383Cyclic GMP, accumulation in

heart, effects of phosphodi-esterase inhibitors on(chicks), 383

Cyclophosphamide, inhibition of

[3H]thymidine incorporationinto DNA (rats), 765

Cyproheptadine, inhibition of

sympathetic nervous dis-

charge (cats), 94Cytosine arabinoside

in central nervous system,pharmacokinetics and me-tabolism of (rabbits), 1

inhibition of DNA synthesisand glial cell proliferation by(rats), 765

Dailey, J. W., see Ko, K. H., 662D’Alonzo, A. J., Argentieri, T. M.

and McArdle, J. J.: Ouabainand tetrodotoxin block themyotonia of skeletal muscle

induced with 20,25-diazacho-lesterol, 401

Daniel, M. A. and Evans, M. A.:Quantitative comparison ofmaternal ethanol and mater-

nal tertiary butanol diet on

postnatal development, 294

Degregorio, C. M., see Shannon,

H. E., 52de Jonge, A., Timmermans, P. B.

M. W. M. and van Zwieten,

P. A.: Quantitative aspects of

alpha adrenergic effects in-duced by clonidine-like imi-dazolidines. I. Central hype-tensive and peripheral hyper-tensive activities, 705

de Jonge, A., Timmermans, P. B.M. W. M. and van Zwieten,P. A.: Quantitative aspects of

alpha adrenergic effects in-duced by clonidine-like imi-dazolidines. II. Central andperipheral bradycardic activ-ities, 712

De Mey, J. G., Claeys, M. andVanhoutte, P. M.: Endothe-lium-dependent inhibitoryeffects ofacetylcholine, aden-osine triphosphate, thrombinand arachidomc acid in thecanine femoral artery, 166

Dentate gyrus, membranes, effectof kindled seizures on [3H]quinucidinyl benzilate bind-

ing sites in (rats), 670Dershwitz, M. and Novak, R. F.:

Studies on the mechanism ofmtrofurantoin-mediated red

cell toxicity, 430DeRubertis, F. R., see Craven, P.

A., 306Desensitization

of d-nicotine (rats), 463to norepinephrine, role of con-

tractility in ear artery on(rabbits), 338

Desipramine, suppression of his-tamine-induced adrenocorti-cotropic hormone release by(rats), 583

Desmethylimipramine

effect on fixed-interval re-sponding (squirrel monkeys),215

effect on melatonin concentra-tion in pineal gland (rats), 534

Dewey, W. L, see Chau, T. T.,612

Diabetes, streptozotocin, effect onmyocardial sodium pump andcontractility of heart (rats),

3953,4-Diaminopyridine, effect on be-

havior and acetylcholine me-

tabolism (mice), 576

20,25-Diazacholesterol-inducedmyotonia of skeletal muscle,

effects of ouabain and tetro-dotoxin (rats), 401

Diazepam

effect on dopamine metabolismin mgrostriatal pathway(rats), 674

-induced sensitization of atriato adenosine (guinea pigs),752

protective action against ansi-triptyline-induced toxicity(cats), 424

suppression of histamine-in-

duced adrenocorticotropic

790 Index Vol. 222

hormone release by (rats),583

Dichloroacetate, metabolic and

toxic effects, comparison with

2-chloropropionate (rats,

mice), 501i,i-Dichloroethylene, effect on

hepatic phase I and II tram-formation (rats), 47i

Diet, maternal ethanol and ma-temal t-butanol, comparison

on postnatal development

(mice), 294Diethyldithiocarbamate, effect on

seizure intensity (rats), 662Diethylnitriamine pentaacetic

acid, effect on chelation of

cadmium (rats), 699a-Difluoromethylornithine

effects on development (rats),

741

effects on nervous system de-

velopment (rats), 746Digoxin, renal clearance, effect of

quinidine (dogs), 49

L-Dthydroxyphenylalanme, effect

on seizure intensity (rats),662

Diltiazem

effect on cardiac output distri-

bution (rats), 359effect on ischemic myocardial

pH (dogs), 720

effect on normal and ischemic

myocardium (dogs), 4942,3-Dimercaptopropranol, effect

on chelation of cadmium(rats), 699

Diphenydramine

effect on fixed-interval re-

spending (squirrel monkeys),

215

effect on histamine-induced ad-renocorticotropic hormonerelease (rats), 583

Dispositionof isopropylamine (dogs), 116

of vancomycin, effect of furo-

semide (rabbits), 237Distribution

of cardiac output, effects of dil-

tiazem on (rats), 359ofinulin and gallamine in extra-

cellular fluid space (dogs),389

Disulfides, inhibition of norepi-nephrine accumulation insympathetic nerve endings

by (mice, rats), 419

Dithiothreitol, inhibition of nor-

epinephrine accumulation insympathetic nerve endings

by (mice, rats), 419

Diuresis, variability, effect of

chloramphemcol on (rats),

232

Diuretics, stimulation of prosta-

glandin synthesis by (rats),

306DNA, synthesis, effects of inhibi-

tors on post-traumatic glialcell proliferation (rats), 765

Dobutamine, protective actionagainst amitriptyline-in-

duced toxicity (cats), 424Dopamine

development in brain (rats), 746

in central nervous system, ef-fect on seizure intensity

(rats), 662

metabolism, drug-induced

changes (rats), 674

-opiate interaction in pedal gan-

glia (molluscs), 759

protective action against aim-

triptyline-induced toxicity

(cats), 424

release in striatal slices, modu-

lation by delta opiate ago-

nists (rats), 435Doxepin, suppression of hista-

mine-induced adrenocortico-

tropic hormone release by

(rats), 583

Drugs

alpha and beta adrenergic,

stimulation of fl-endorphin

release from pituitary (rats),

103

tricycic antidepressant and an-

ticholinergic, effects on fixed-

interval responding (squirrel

monkeys), 215

Dubois, A., see Shea-Donohue, P.

T., 379Duchene-Marullaz, D., see Chas-

saing, C., 688Duckles, S. P. and Kennedy, C.

D.: Cerebral blood vessels:Effects of exogenous acetyl-

choline and field stimulationon norepinephrine release,562

Duman, R., see Kendall, D. A.,

566

Dunnette, J. H., see Woodson, L.C., 174

du Souich, P., see Lambert, C.,

232

Dynorphin, effect on kappa opi-ate receptors in ileum (guinea

pigs), 71

Electrophysiology, cardiac, effects

of enflurane on (guinea pigs),405

Electrophysiological study, on ef-fects of alpha-i and alpha-2antagonists (rats), 287

Elimination, of inulin and galla-mine (dogs), 389

Ellens, H., Rustum, Y., Mayhew,E. and Ledesma, E.: Distri-bution and metabolism oflipsome-encapsulated andfree i-$-D-arabinofuranosyl-cytosine (Ara-C) in dog andmouse tissues, 324

fl-Endorphin, release from pitui-tary, adrenergic control

(rats), 103Endothelium-dependent effects of

acetylcholine, adenosine tn-phosphate, thrombin and ar-achidomc acid in femoral ar-tery (dogs), 166

Endotoxin

-induced fever, role of norepi-nephrine-cycic AMP link on(rats), 251

-induced pulmonary hyperten-sion, prevention with OXY

1581 (baboons), 441

End-plate currents, inhibition by

streptomycin (frogs), 488

Enflurane, effect on papillarymuscle (guinea pigs), 405

Enkephalins, analgesia, compari-

son with morphine (rats), 190

Enna, S. J., see Kendall, D. A.,

566

Enzyme, inhibitor, angiotensin Iconverting, hypotensive ac-

tion of (dogs), 246Erickson, R. R., see Tsuru, M.,

658i7�8-Estradiol, effect on sympa-

thetic nerve stimulation and

noradrenaline concentration

in radial artery (cows), 731

Estrogens, conjugated, central

cardiovascular effects (rats),

726Ethanol

effect on opiate receptors

(mice), 182-induced increases in alcohol

dehydrogenase-dependentmetabolism of ethanol, roleof testosterone (rats), 20

maternal diet, comparison withmaternal t-butanol diet on

postnatal development

(mice), 294sensitivity of cerebellar grafts

(mice), 480Etorphine, effect on dopamine

levels in pedal ganglia (mol-

luscs), 759

Ethylcholine mustard aziridinium

ion-induced long-term cho-linergic hypofunction (mice),

140Ethyl isocyanate, effects on nitro-

furantoin-mediated depletion

of red cell reduced glutathi-one (man), 430

Evans, M. A., see Daniel, M. A.,294

Excretionbiliary, of morphine, effect of

trans-stilbene oxide on (rats),526

of hippurate in kidney, effect ofbenzoate (man), 572

renal, of vancomycin, effect offurosemide on (rabbits), 237

Eye, cornea, lesions induced by

antidepressants (rats), 282

Farley, J. M., Wu, C. H. and Nar-ahashi, T.: Mechanism ofneuromuscular block bystreptomycin: A voltageclamp analysis, 488

Felten, S. Y., see Yount, E. A., 501Fenfluramine-induced release of

serotonin (rats), 220

Fever, induced by endotoxin andprostaglandin E2, role of nor-epinephrine-cycic AMP linkon (rats), 251

Fisher, A., Mantione, C. R., Abra-ham, D. J. and Hanin, I.:Long-term central choliner-gic hypofunction induced inmice by ethylcholine aziridi-

alum ion (AF64A) in vivo,

140

Flaim, S. F. and Zelis, R.: Effects

of diltiazem on total cardiac

output distribution in con-

scious rats, 359Fletcher, J. R., see Casey, L. C.,

441

Follmer, C. H. and Lum, B. K. B.:

Protective action of diaze-

pam and of sympathomi-

metic amines against amitnip-tyline-induced toxicity, 424

Foltin, R. W. and Schuster, C. R.:

Behavioral tolerance andcross-tolerance to dl-cathi-

none and d-amphetamine inrats, 126

Fraser, A., see Heydorn, W. E.,

534Freedman, R., see Palmer, M. R.,

480

Fuhrman-Lane, C. and Fujimoto,J. M.: Tran�-stilbene oxideadministration increased he-patic glucuronidation of mor-phine but decreased biliary

excretion of morphine glucu-romde in rats, 526

Fujimoto, J. M., see Fuhrman-Lane, C., 526

Fujiwara, M., see Ikusbima, S.,

463Furosemide

calcium-dependent stimulationof renal medullary prosta-glandin synthesis (rats), 306

influence ofliver metabolism on

diuretic response to (rats),

232

-vancomycin interactions (rab-bits), 237

Gaifrey, T. E., see Privitera, P. J.,

116Gangliomc blockade, after stimu-

lation of autonomic gangliaby isopropylamine (dogs),116

Garcia, J. C., see Nova, J. M. L.,

447GarcIa-Suinz, J. A., see Villalobos-

Molina, R., 258Gastrin release, effects of methi-

onine-enkephalin, morphineand naloxone on 2-deoxy-D-glucose-induced vagal stimu-

lation of (dogs), 617Gastrointestinal activity, effects

of thyrotropin releasing hor-

mone on (rabbits), 66Gastrointestinal transit, stimula-

tion by thyrotropin-releasinghormone (rabbits), 367

Gemba, M., see Matsushima, Y.,

452Gentamicin, binding to renal

brush border membranes(rats), 350

Gerber, J. G., see Olson, R. D., 606

Gerkens, J. F., see Jackson, E. K.,

410, 414Gibson, G. E., see Peterson, C.,

576

Gibson, T. P., see Clohisy, D. R.,49

Gioannini, T. L, see Howells, R.

1982 Index 791

D., 629Gland, pituitary, adrenergic con-

trol of $-endorphin releasefrom (rats), 103

Gleason, J. G., see Weichman, B.

M., 202Glowinski, J., see Lubetzki, C., 435Glutathione, reduced, in red cells,

studies on mtrofurantoin-me-

diated depletion of (man),430

Glycine, metabolism, benzoate-in-duced changes in (man), 572

Goldman, S., Olajos, M. and Mor-

kin, E.: Effects of verapamilon positive inotropic stimu-lation in the left atrium andventricle of conscious dogs,

270

Gomem, R, see Roach, A. G., 680Gormley, J. M., see Richter, J. A.,

778

Gregus, Z., Watkins, J. B.,Thompson, T. N. and Klaas-

son, C. D.: Resistance of somephase II biotransformationpathways to hepatotoxins,

471

Gnignolo, A., see Slotkin, T. A.,

746

Gross, G. J., Buck, J. D., Warltier,D. C. and Hardman, H. F.:

Role of autoregulation in thebeneficial action of propran-olol on ischemic blood flowdistribution and stenosis se-verity in the canine myocar-dium, 635

Gross, G. J., see Zyvoloski, M. G.,494

Guanfacine-induced sleep time,

inhibition by alpha-2 adre-noceptor antagonists (chicks,rats), 680

Haegele, K. D., see Clementi, W.A., 159

Haigler, H. J., see O’Neffl, T. P.,555

Halopenidol, effect on histamine-

induced arousal (rats), 37Hanin, I., see Fisher, A., 140Harden, T. K. and McCarthy, K.

D.: Identification of the beta

adrenergic receptor subtypeon astroglia from rat brain,600

Hardman, H. F., see Gross, G. J.,635

Harris, R A., see Yount, E. A.,

501Hauser, G., see Pappu, A. S., 109Heart

adenylate cyclase and beta ad-renergic receptor develop-ment in (mice), 7

development of ornithine de-carboxylase and polyasninesin (rats), 74i

effects of benzodiazepines onsensitization of atnia to aden-osine (guinea pigs), 752

effects of enflurane on myocar-dial action potentials (guineapigs), 405

effects of propranolol on is-

chemic blood flow and ste-nosis severity in (dogs), 635

effects of streptozotocin diabe-tes and insulin treatment on

sodium pump and contractil-ity of (rats), 395

effects of verapamil on ino-

tropic stimulation of leftatrium and left ventricle in(dogs), 270

ischemic, effect of diltiazem onmyocardial pH in (dogs), 720

isolated, inotropic effects ofvanadate (rats, guinea pigs),132

underperfused, effects of nitro-

glycerin on transmural en-ergy metabolism in (dogs),694

Heart rate, mechanism of actionof quinidine on (dogs, guineapigs), 688

Hemodynamicseffects of calcium antagonists

(dogs), 494

of kidney, effects of adenosineon (rats), 319

of myocardial metabolites, ef-fects of nitroglycerin (dogs),

694renal, effect of vanadate on

(dogs), 447

Henthorn, T. K., Avram, M. J.Frederiksen, M. C. and At-kinson, A. J., Jr.: Heteroge-neity of interstitial fluid

space demonstrated by si-multaneous kinetic analysisof the distribution and elimi-nation of inulin and galla-mine, 389

Hepatocytes, isolated, effect onmetabolism of phenytoin

(rats), 658Hepatotoxins, resistance of some

Phase H biotransformationpathways to (rats), 471

Hermansson, J., see von Bahr, C.,458

Herzer, W. A., see Jackson, E. K.,

414

Heydorn, W. E., Brunswick, D. J.and Fraser, A.: Effect oftreatment of rats with anti-depressants on melatoninconcentrations in the pinealgland and serum, 534

Higuchi, M.: Effects of nitroglyc-em on transmural energymetabolism in the underper-fused canine heart, 694

Hiller, J. M., see Howells, R. D.,629

Hippurate, production in kidney

effect of benzoate (man), 572Hirschowitz, B. I., see Anderson,

w., 617

Histamine

-induced adrenocorticotropichormone release, inhibitionby antihistamines and anti-depressants (rats), 583

-induced arousal (rats), 37release, 48/80-induced, compet-

itive inhibition of (rats), 652Hoffer, B., see Palmer, M. R., 480

Hoffman, P. L., Urwyler, S. andTabakoff, B.: Alterations inopiate receptor function after

chronic ethanol exposure, 182Holden, D. A., see Weichman, B.

M., 202Hollinger, M. A.: Biochemical ev-

idence for pulmonary endo-

thelial cell injury after carbontetrachlonide administration

in mice, 641Holtzman, J. L., see Tsuru, M.,

658

Holtzman, S. G., see Brady, L. S.,190

Homma, T. and Malik, K. U.: Ef-fect ofprostaglandins on pan-

creatic circulation in anesthe-tired dogs, 623

Hong, E., see Villalobos-Molina,

R., 258Hong, S. M., see Read, G. W., 652Horita, A., see LaHann, T. R, 66Horita, A. and Canino, M. A.:

Centrally administered thy-rotropin-releasing hormone(TRH) stimulated colonictransit and diarrhea produc-tion by a vagally mediatedserotonergic mechanism inthe rabbit, 367

Hormone (see also specific name)

adrenocorticotropic, histamine-

induced release, inhibition byantihistamines and antide-pressants (rats), 583

adrenocorticotropic, influence

on antidepressant-induceddecline in brain neurotrans-

mitter receptor binding

(rats), 566Horning, M. G., see Pang, K. S.,

14

Howells, H. D., Gioannini, T. L,

Hifier, J. M. and Simon, E.J.: Solubilization and char-actenization of active opiatebinding sites from mamma-han brain, 629

Huidobro-Toro, J. P., Caturay, E.

M., Ling, N., Lee, N. M., Loh,

H. H. and Way, E. L: Studieson the structural prerequi-sites for the activation of the

/3-endorphin receptor on therat vas deferens, 262

Huidobro-Toro, J. P., see Yoshi-

mura, K., 71

Humes, H. D., see Sastrasinh, M.,350

Humphrey, S. J., see McCall, R.

B., 94Hyalomdase, bovine testicular,

semis kinetics of (dogs, rats,man), 331

Hydralazine, from labile hydra-zones, generation of (rats,

rabbits), 159Hydrazone, labile, generation of

hydralazine from (rats, rab-bits), 159

5-Hydroxytryptamine, in centralnervous system, effect on sei-zure intensity (rats), 662

5-Hydroxytryptophan, inhibitionof phremc nerve activity by

(cats), 771

Hypertension, endotoxin-induced

pulmonary, prevention withOXY 1581 (baboons), 441

Hypofunction, cholinergic, long-term, induced by ethylcho-line mustard aziridinium ion(mice), 140

Hypotension, effect of isopropyl-amine on (dogs), 116

Hypothalamus, role in fever pro-duction of norepinephnineand cyclic AMP systems of(rats), 251

Hypoxia, effect of 3,4-diaminopy-ridine on behavior and acetylcholine metabolism during

(mice), 576

Ichihara, K. and Abiko, Y.: Effectof diltiazem, a calcium antag-omit, on myocardial pH inischemic canine heart, 720

Ijichi, H., see Takashi, H., 726Ikushima, S., Muramatsu, I., Yo-

kotani, Y. S. K. and Fujiwara.M.: The effects of d-mcotineand I-isomer on mcotinic re-ceptors, 463

Heumeffect of dynorphin on kappa

opiate receptors in (guineapigs), 71

evaluation of alpha-2 adrener-

gic effects of cirazoline in

(guinea pigs), 29twitch-like contractions, inhi-

bition by saline-treated brainextracts (mice, guinea pigs),612

Imidazolidines

clonidine-like, bradycardic ac-tivities (rats), 712

clonidine-like, hype- and hy-pertensive activities (rats),705

receptor interactions, alpha-iand alpha-2 adrenergic ef-fects of cirazoline (guinea

pigs), 29Imipramine

effect on fixed-interval re-spending (squirrel monkeys),215

suppression of histamine-in-duced adrenocorticotropichormone release by (rats),583

Indomethacineffect on beta adrenoreceptor-

stimulated renin release(dogs), 414

effect on leukotniene-inducedbronchoconstruction in vitro

and in vivo (guinea pigs), 202effect on pancreatic blood flow

and exocrine secretion (dogs),623

Indoramin, effect on clonidine-in-duced sleeping time (chicks,rats), 680

Insulin, effects on myocardial so-

dium pump and contractilityof heart (rats), 395

Iprindole, suppression of hista-

mine-induced adrenocortico-

792 Index

tropic hormone release by(rats�, 583

i-Isomer, effects on nicotinic re-ceptors (rats), 463

Isopropylamine, nicotinic-like ef-fects and tissue disposition(dogs), 116

Isoproterenoleffects on cyclic AMP levels in

heart (chicks), 383-mediated increase in renin

release, effect of beta adre-

noceptors (dogs), 606protective action against ansi-

triptyline-induced toxicity

(cats), 424L-Isoproterenol-stimulated eleva-

tion of malatonin, effect ofnialamide treatment on(rats), 534

Izazola-Conde, C., see Chau, T. T.,612

Jackson, E. K., Gerdens, J. F. andBranch, R. A.: Acute renalartery constriction increases

renal prostaglandin 12 biosyn-

thesis and renin release in the

conscious dog, 410Jackson, E. K., Herzer, W. A.,

Zimmerman, J. B., Oates, J.

A., Branch, R. A. and Ger-kens, J. F.: Effects of indo-methacin on beta adreno-receptor-stimulated reninrelease in the dog, 414

Jackson, M. J., see Tai, C.-Y., 372Jobe, P. C., see Ko, K. H., 662

Kalivas, P. W.: Histamine-in-duced arousal in the con-scious and pentobarbital-pre-treated rat, 37

Kalkman, H. 0., Timmermans,P.B.M.W.M., and van Zwie-ten, P. A.: Characterization of

the antihypertensive proper-

ties of ketanserin (R 41 468)in rats, 227

Kaisner, S., see Chan, C.-C., 731

Kenakin, T. P.: The potentiationof cardiac responses to aden-

osine by benzodiazepines, 752

Kendall, D. A., Duman, R., Slopis,

J. and Enna, S. J.: The influ-

ence of adrenocorticotropinand yohimbine on antide-pressant-induced declines in

rat brain neurotransmitterreceptor binding and func-tion, 566

Kennedy, C. D., see Duckles, S.

P., 562

Kerr, L. M. and Sperelakis, N.:Effects of the calcium antag-

onists bepridil (CERM-i978)

and verapamil on Ca�-de-pendent slow action poten-

tials in frog skeletal muscle,80

Ketamine-induced loss of rightingreflex and sleeping time, po-tentiation by cocaine (mice),

122

Ketanserin, hypotensive proper-ties of (rats), 227

Kidneyartery constriction in, effect on

prostaglandin 12 biosynthesisand renin release (dogs), 410

binding of gentamicin to brushborder membranes in (rats),350

clearance of digoxin, effect ofquinidine (dogs), 49

cortex mince, propranolol effecton lipids (rats), 109

cortical slices, stimulatory ac-tion of verapamil on tram-port of organic acids in (rats),452

development of ornithine de-carboxylase and polyamines

in (rats), 741

distribution and elimination ofinulin and gallamine in(dogs), 389

effects of indomethacin on betaadrenoceptor-stimulated re-nm release in (dogs), 414

effect of sodium orthovanadateon renin secretion in (dogs),447

function, effects of aminophyl-line on (rats), 319

medulla slices, stimulation bydiuretics on prostaglandin

synthesis in (rats), 306role of beta adrenoceptor sub-

types on renin release (dogs),606

thiopurmne methyltransferase

activity in (man), 174

vasodilator effects of prosta-glandin analog (dogs, rats),152

Kidney failure, chronic, benzoate-

induced changes in glycineand urea metabolism in pa-tients with (man), 572

Kiefer, E. F., see Read, G. W., 652

Kinetics (see also Pharmacoki-netics)

metabolite, formation of acet-

aminophen in perfused liver(rats), 14

of inulin and gallamine (dogs),

389serum, of hyaluronidase (dogs,

rats, man), 33iKlaassen, C. D., see Gregus, Z.,

471

Knauss, T. C., see Sastrasinh, M.,

350Ko, K. H., Dailey, J. W. and Jobe,

P. C.: Effect of selective in-crements in norepinephrineconcentrations on seizure in-tensity in the genetically epi-lepsy-prone rat, 662

Kojic amine, effect on dopaminemetabolism in nigrostriatal

pathway (rats), 674

Kolaja, G. J., see Vonvoigtlander,P. F., 282

Kream, R. M., see Stefano, G. B.,

759

Ku, D. D. and Sellers, B. M.: Ef-fects of streptozotocin diabe-

tes and insulin treatment on

myocardial sodium pump andcontractility of the rat he’trt,

395

Labetol, effect on clonidine-in-

duced sleeping time (chicks,rats), 680

La Hams, T. R. and Horita, A.:

Thyrotropin releasing hor-mone: Centrally mediated ef-fects on gastrointestinal mo-tor activity, 66

Lalley, P. M., see McCrimmon, D.

R., 77iLambert, C., Caill#{233},G. and du

Souich, P.: Nonrenal clear-ance of furosemide as a causeof diuretic response vaniabil-ity in the rat, 232

Langer, S. Z. and Moret, C.: Ci-talopram antagonizes the

stimulation by lysergic acid

diethylamide of presynapticinhibitory serotonin autore-

ceptors in the rat hypothala-mus, 220

Lapollo, J., see Vanderwende, C.,122

Lateral geniculate, nucleus, ef-fects of alpha-i and alpha-2

antagonists on (rats), 287Le Breton, G. C., see Parise, L. V.,

276

Ledesma, E., see Ellens, H., 324Lee, N. M., see Huidobro-Toro, J.

P., 262Lee, N. M., see Yoshimura, K., 7i

Lef#{232}vre-Borg, F., see Roach, A.G., 680

Lerea, G. A., see Slotkin, T. A.,

741, 746

Leukotriene-mediated broncho-constriction, in vitro and in

vivo mechanisms (guineapigs), 202

Leventer, S. M., Rowell, P. P. and

Clark, M. J.: The effect ofcholine acetyltransferase in-hibition on acetylcholine syn-thesis and release in term hu-

man placenta, 301Liii, M. T., Wu, J. J., Chandra, A.

and Tsay, B. L.: A norepi-nephrine-cycic AMP link inthe hypothalamic pathways

which mediate fever inducedby endotoxin and prostaglan-

din E2 in the rat, 251

Lind, M., see von Bahr, C., 458Linden, J., Vogel, S. and Spere-

lakis, N.: Sensitivity of Ca-de-

pendent slow action poten-tials to methacholine is in-

duced by phosphodiesteraseinhibitors in embryonic chick

ventricles, 383Ling, N., see Huidobro-Toro, J.

P., 262Lisuride, effect on sympathetic

nervous discharge (cats), 94

Liverdistribution and metabolism of

lipsome-encapsulated andfree 1-$-D-arabrnofuranosyl-cytosine in (dogs, mice), 324

metabolism of furosemide by

(rats), 232microsomal metabolism of

phenytoin (rats), 658microsomes, oxidation of (R)-

and (S)-propranolol in (man,

dogs), 458

Vol. 222

mince, propranolol effects onlipids (rats), 109

perfused, effect of trans-stil-bene oxide on excretion ofmorphine (rats), 526

perfused, formation of acet-aminophen from phenacetinand acetanilide on sulfationkinetics in (rats), 14

Locus ceruleus, nucleus, effects ofalpha-i and alpha-2 antago-nists on (rats), 287

Loh, H. H., see Hudiobro-Toro, J.P., 262

Loh, H. H., see Yoshimura, K., 7iLubetzki, C., Chesselet, M. F. and

Glowinski, J.: Modulation ofdopamine release in rat stria-tal slices by delta opiate ag-onists, 435

Ludden, T. M., see Clementi, W.A., 159

Lukacsko, P. and Blumberg, A.:Modulation of the vasocon-

stnictor response to adrener-gic stimulation by nucleo-sides and nucleotides, 344

Lum, B. K. B., see Foilmer, C. H.,424

Lungangiotensin converting enzyme

levels, effect of carbon tetra-chloride (mice), 641

parenchymal strips, effects ofindomethacin and meclofen-amic acid on leukotriene-in-duced contractions in (guineapigs), 202

LY135252, inhibition of norepi-

nephnine uptake in brain by(rats), 61

Lynch, C., HI, Vogel, S., Pratila,M. G. and Sperelakis, N.: En-flurane depression of myocar-

dial slow action potentials,405

Lysergic acid diethylamide, inhi-bition of serotonin release(rats), 220

Malik, K. U., see Homma, T., 623Mandel, H. G., see Bilhingsley, M.

L., 765Mantione, C. R., see Fisher, A.,

140

Martinez-Maldonado, M., see

Nova, J. M. L., 447Marwaha, J. and Aghajanian, G.

K.: Relative potencies of al-pha-1 and alpha-2 antago-rnsts in the locus ceruleus,dorsal raphe and dorsal lat-eral geniculate nuclei: Anelectrophysiological study,

287

Matsushima, Y. and Gemba, M.:Stimulatory action of vera-pamil on transport of organicacids in rat kidney corticalslices, 452

Mayhew, E., see Ellens, H., 324Maynard, J. R., see Crutchley, D.

J., 544McCall, R B. and Humphrey, S.

J.: Involvement of serotoninin the central regulation ofblood pressure: Evidence for

1982 Index 793

a facilitating effect on sym-pathetic nerve activity, 94

McArdle, J. J., see Argentieri, T.

M., 401

McCarthy, K. D., see Harden, T.K., 600

McCrimmon, D. R. and Lalley, P.M.: Inhibition of respiratoryneural discharges by clom-dine and 5-hydroxytrypto-phan, 771

McKearney, J. W.: Effects of tri-cyclic antidepressant and an-ticholinergic drugs on fixed-

interval responding in thesquirrel monkey, 2i5

McNamara, J. 0., see Savage, D.D., 670

McNay, J. L., see Clementi, W.A., 159

Meclofenamate, effect on pan-

creatic blood flow and exo-crine excretion (dogs), 623

Meclofenamic acid, effect on

leukotriene-induced bron-choconstriction in vitro andin vivo (guinea pigs). 202

Melatonin, in pineal gland, effectof antidepressants on (rats),534

Mepyramine, effect on histamine-

induced adrenocorticotropin

hormone release (rats), 58316-Mercaptoethanol, inhibition of

norepinephrine accumula-tion in sympathetic nerveendings by (mice, rats), 419

Metabolism

dopamine, effect of morphine(mice), 182

of acetylcholine, during hy-poxia, effect of 3,4-diamino-pyridine on (mice), 576

of 1-$-D-arabinofuranosylcyto-sine (dogs, mice), 324

of arachidomc acid (dogs), 166of cytosine arabinoside in cen-

tral nervous system (rabbits),

of dopamine (rats), 674of dopamine, effects of mu and

delta opiate agonists (rats),435

of ethanol, alcohol dehydroge-nase-dependent, role of tea-tosterone (rats), 20

of furosemide by liver (rats),232

of glycine and urea, benzoate-induced changes in (man),572

of hydralazine (rats, rabbits),159

ofmorphine, effect of trans-stil-bane oxide on (rats), 526

of phenytoin by isolated hepa-tocytes and hepatic micro-somes (rats), 658

of phospholipid, effects of pro-pranolol (rats), 109

of polyphosphoinositide, in-volvement of alpha noradre-nergic receptors in mediation

of (rats), 209of propranolol in liver (man,

dogs), 458of transported drugs, (rats), 372

transmural energy, in heart, ef-fects of nitroglycerin on(dogs), 694

Metallothionein, chelation of cad-mium from (rats), 699

Metergoline, inhibition of sym-

pathetic nervous discharge(cats), 94

Methacholine, effects on cyclic

AMP levels in heart (chicks),

383

Methionine-Enkephalin, effect ongastric secretion and gastrin

release (dogs), 617Methiothepin, effect on inhibition

by lysergic acid diethylamideof serotonin release (rats),220

5-Methoxydimethyltryptamine,

effect on sympathetic nerv-ous discharge (cats), 94

a-Methylnorepinephnine

-induced sleep time, inhibitionby alpha-2 adrenoceptor an-tagonists (chicks, rats), 680

isomers, alpha adrenergic ef-fects of (guinea pigs), 645

Methysergide, inhibition of sym-pathetic nervous discharge(cats), 94

Meyer, E. R., see Cicero, T. J., 20Mianserin, suppression of hista-

mine-induced adrenocortico-tropin hormone release by(rats), 583

Microsomes, liver, oxidation of(R)- and (S)-propranolol in(man, dogs), 458

Miles, D. L, see Paul, M. L., 241Milk intake, effects of dl-cathi-

none and d-amphetamine on(rats), 126

Mitch, W. E. and Brusiow, S.:Benzoate-induced changes in

glycine and urea metabolismin patients with chronic renalfailure, 572

Miura, K., Abe, Y. and Yama-moto, K.: Hypotensive actionof angiotensin I converting

enzyme inhibitor (SQ 14, 225)in nephrectomized dogs, 246

Molina, E., see Anderson, W., 617

Moret, C., see Langer, S. Z., 220

Morkin, E., see Goldman, S., 270

Morphine

affinity for opiate receptors invivo (rats), 198

analgesia, comparison with en-kephalins (rats), 190

effect on dopamine metabolism(mice), 182

effect of trans-stilbene oxide onmetabolism and excretion of

(rats), 526effect on gastric secretion and

gastrin release (dogs), 617-induced increases in alcohol

dehydrogenase - dependentmetabolism of ethanol, roleof testosterone (rats), 20

-like materials in brain, peptideand nonpeptide, effect ofacetylcholine (mice, guineapigs), 612

pretreatment, effect on potencyof f1-endorphin (rats), 262

Muccitelli, R. M., see Weichman,B. M., 202

Mueller, G. P., see Pettibone, D.J., 103

Muller, J. E., see Wolf, R. A., 331Muramatsu, I., see Ikushima, S.,

463Murray, T. F., Blaker, W. D., Che-

ney, D. L and Costa, E.: In-hibition of acetylcholineturnover rate in rat hippo-campus and cortex by intra-ventricular injection of aden-osine analogs, 550

Muscimol, effect on dopaminemetabolism in nigrostriatalpathway (rats), 674

Muscle

papillary, cardiac, depression

by enflurane (guinea pigs),405

skeletal, effects of bepridil andverapamil on Ca�-depend-ent slow action potentials in(frogs), 80

skeletal, effects of ouabain andtetrodotoxin on myotonia of(rats), 401

Musgrave, G. E., see Clementi, W.A., 159

Myers, A., Papadopoulos, A.,O’Day, D., Ramey, E., Ram-well, P. and Penhos, J.: Sex-ual differentiation of arachi-donate toxicity in mice, 315

Myers, L., see Shea-Donohue, P.T., 379

Myocardial ischemia

effects of diltiazem and nifedi-pine (dogs), 494

effect of hyaluromdase on(dogs, rats, man), 331

Myotonia, of skeletal muscle, ef-fects of ouabain and tetrodo-toxin on (rats), 401

Naloxoneantagonism of analgesic effects

of morphine and enkephalins(rats), 190

antagonism of dynorphin

(guinea pigs), 71

antagonism of $-endorphin(rats), 262

effect on gastric secretion and

gastrin release (dogs), 617

a-Naphthylisothio-cyanate, effecton hepatic phase I and IItransformation (rats), 471

Narahashi, T., see Farley, J. M.,

488Narcotics, phencyclidine-like ef-

fects of (rats), 146

Nephrotoxicity, of gentamicin

(rats), 350Nerve, carotid sinus, electrical

stimulation (cats), 771

Nerve activity, sympathetic, ef-

fect of conjugated estrogens

(rats), 726

Nerve development, sympathetic,

effects of a-difluoromethylor-

mthine on (rats), 746

Nerves

adrenergic and cholinergic in

cerebral circulation, effectson norepinephnine release

(cats, rabbits), 562sympathetic, cardiac, disulfides

inhibit norepinephrine accu-mulation in (mice, rats), 419

Nerve terminals, adrenergic, ef-fects of i-isomer on nicotinicreceptors in (rats), 463

Nervous system

central, distribution of [3H]cy-tosine arabinoside into (rats),765

central, pharmacokinetics and

metabolism of cytosine ara-binoside in (rabbits), 1

Nervous system discharge, sym-pathetic, inhibition by sero-toniri receptor agonists andantagonists (cats), 94

Neuromuscular block, by strep-tomycin, mechanism of(frogs), 488

Neuromuscular junction, effect ofpnimidone and phenylethyl-malonamide on nerve-evokedtransmitter release at (frogs),87

Neuromuscular transmission, ef-fects of chloroquine and hy-droxychloroquine (mice, rats,guinea pigs, chicks), 43

Neurons

dopamine, opiate binding on(molluscs), 759

in mesencephalic reticular for-mation, effects of phentol-amine and propranolol onnorepinephrine-evoked fir-

ing (rats), 555Neurotoxicity, of cytosine arabi-

noside (rabbits), 1Neurotoxins, presynaptically act-

ing, interaction with amino-quinolines (mice, rats, guinea

pigs, chicks), 43Neurotransmission, synaptic, ef-

fects of primidone and phen-ylethylmalonamide (frogs),

87

Neurotransmitter release, nerve-evoked, at neuromuscularjunction, effect of primidone

and phenylethylmalonamide(frogs), 87

Newman, K. S., see Cicero, T. J.,20

Nialamide, effect on melatoninconcentration in pineal gland(rats), 534

d-Nicotine, effects on nicotinic re-ceptors (rats), 463

Nies, A. S., see Olson, R. D., 606Nifedipine

effect on normal and ischemicmyocardium (dogs), 494

effect on renal renin secretion(dogs), 447

Nigrostriatal pathway, actions ofGABAergic agents on dopa-mine metabolism in (rats),674

Ni�rofurantoin-mediated red cell

toxicity, studies on mecha-

ni.�m of (man), 430Nitroglycerin, effects on tram-

mural energy metabolism inheart (dogs), 694

Nivoche, Y., Contrepois, A., Cre-

794 Index Vol. 222

mieux, A-C. and Carbon, C.Vancomycin in rabbits: Phar-macokinetics, extravasculardiffusion, renal excretion andinteractions with furosemide,237

Nompleggi, D., see Shea-Dono-hue, P. T., 379

Noradrenaline, in radial artery,effects of cocaine and 17-�6-

estradiol (cows), 731Norepinephnine

accumulation in sympatheticnerve endings, inhibition bydisulfides (mice, rats) 419

contractility in ear artery masksdesensitization to (rabbits),338

-cyclic AMP link, role in endo-toxin- and prostaglandin E2-induced fever (rats), 251

development in brain and pe-ripheral nerves (rats), 746

effects on polyphosphoinositidemetabolism (rats), 209

-evoked neuronal firing in mes-encephalic reticular forma-

tion, effects of phentolamineand propranolol on (rats), 555

in central nervous system,effect on seizure intensity(rats), 662

isomers, alpha adrenergic ef-fects of (guinea pigs), 645

protective action against ami-

triptyline-induced toxicity

(cats), 424

release in cerebral arteries, ef-fect of acetylcholine (cats,rabbits), 562

Nortriptyline, effect on fixed-in-terval responding (squirrelmonkeys), 215

Nova, J. M. L, Garcia, J. C., Crux-Soto, M. A., i3enabe, J. E.and Martinez-Maldonado,M.: Effect of sodium ortho-vanadate on renal resin se-cretion in vivo, 447

Novak, R. F., see Dershwitz, M.,430

Oates, J. A., see Jackson, E. K.,

414O’Connor, B. L., see Yount, E. A.,

501O’Day, D., see Myers, A., 315O’Hara, D., see Wolf, R A., 331Olajos, M., see Goldman, S., 270Olson, L., see Palmer, M. R., 480Olson, R D., Nies, A. S. and Ger-

bar, J. G.: Beta adrenergicallymediated release of renin inthe dog is not confined to

either beta-i or beta-2 adre-noceptors, 606

O’Neill, T. P. and Haigler, H. J.:Characteristics of adrenocep-tore in a nociceptive pathway

in the mesencephalic reticu-lar formation of the rat, 555

Opiate binding, to buprenorphine

(rats), 198

Opioids, endogenous, release intocerebrospinal fluid frombrain, effects of morphine on

(mice, guinea pigs), 612Organic acids, transport in kidney,

stimulatory action of verapa-

mil on (rats), 452

Ornithine decarboxylaseeffects of inhibition on devel-

opment of nervous system(rats), 746

role in tissue growth and devel-opment (rats), 741

Osborn, R R, see Weichman, B.

M., 202Ouabain

effect on 20,25-diazacholes-

terol-induced myotonia ofskeletal muscle (rats), 401

effect on myocardial sodium

pump and contractility ofheart (rats), 395

OXY 1581, thromboxane synthe-tase inhibitor, prevention of

endotoxin-induced pulino-nary hypertension by (ba-boons), 441

Oxymetazoline-induced sleeptime, inhibition by alpha-2adrenoceptor antagonists(chicks, rats), 680

Paire, M., see Chassaing, C., 688Palmer, M. R., Sorensen, S. M.,

Freedman, R., Olson, L., Hof-fer, B. and Seiger, A.: Differ-

ential ethanol sensitivity ofintraocular cerebellar grafts

in long-sleep and short-sleepmice, 480

Pang, K. S., Wailer, L, Horning,M. G. and Chan, K. K.: Me-tabolite kinetics: Formation

of acetaminophen from deu-terated and nondeuteratedphenacetin and acetanilideon acetaminophen sulfationkinetics in the perfused ratliver preparation, 14

Papadopoulos, A., see Myers, A.,315

Pappu, A. S. and Hauser, G.:Phospholipid metabolismchanges in rat tissue in vitroafter injections of proprano-lol, 109

Parise, L. V., Venton, D. L andLe Breton, G. C.: Thrombox-ane A2/prostaglandin H2 di-rectly stimulates platelet

shape change independent ofsecreted ADP, 276

Paul, M. L., Miles, D. L and Cook,M. A.: The influence of gly-cosidic conformation andcharge distribution on activ-ity of adenine nucleosides aspresynaptic inhibitors of ace-tylcholine release, 241

Penhos, J., see Myers, A., 315Pentobarbital, inhibition of cho-

line uptake in hippocampusby (rats), 778

Pentobarbital narcosis, effect of

histamine (rats), 37

Peterson, C. and Gibson, G. E.:3,4-Diaminopyridine altersacetylcholine metabolismand behavior during hypoxia,

576

Peterson, R. G., see Yount, E. A.,

501Pettibone, D. J. and Mueller, G.

P.: Adrenergic control ofimmunoreactive �8-endorphinrelease from the pituitary ofthe rat: In vitro and in vivo

studies, 103Pharmacogentics, of thiopurine

methyltransferase (man), 174Pharmacokinetics

of cytosine arabinoside in cen-tral nervous system (rabbits),1

of vancomycin, effect of furo-seaside on (rabbits), 237

Phenacetin, deuterated and non-deuterated, role in formationofacetaminophen in perfused

liver (rats), 14Phencycidine-like effects of nar-

cotics (rats), 146

Phenobarbital, interaction with

propranolol (dogs), 589Phenothiazines, inhibition of cal-

modulin by (rats), 509Phenoxybenzamine

antagonism of central nervousadrenoceptors by (cats),771

inhibition of thyrotropin releas-ing hormone effect on gas-trointestinal activity (rab-bits), 66

Phentolamineeffect on norepinephrine-

evoked neuronal firing inmesencephalic reticular for-mation (rats), 555

inhibition of clomdine-inducedsleeping time by (chicks,rats), 680

Phenylethanolamine, self-admin-istration, behavioral effects

(dogs), 52,8-Phenylethylamine, self admin-

istration, behavioral effects(dogs), 52

Phenylethylmalonamide, effecton nerve-evoked transmitterrelease at neuromuscularjunction (frogs), 87

N-methyl Phenylethamine, selfadministration, behavioraleffects (dogs), 52

Phenylisopropyladenosine, L andD isomers, comparison of ef-fects on acetylcholine turn-

over rate in brain (rats), 550Phenytoin, metabolism by iso-

lated hepatocytes and he-patic microsomes (rats),658

Phosphatidic acid, labeling in-crease by propranolol (rats),109

Phosphatidylcholine, labeling de-crease by propranolol (rats),109

Phosphatidylinositollabeling, andcontraction in aorta, effect ofalpha-i adrenergic receptor

on (rabbits), 258Phospodiesterase inhibitors, po-

tentiation of cyclic GMP ac-

cumulation in heart (chicks),383

Phospolipid, metabolism, effects

of propranolol (rats), 109Phospolipids, acidic, interaction

with aminoglycosides (rats),350

Physostigmine-induced toxicity,

protective effects of clonidineon (mice), 595

Pineal gland, effect of antidepres-sants on melatonin concen-trations in (rats), 534

Placenta, term, effect of cholineacetyltransferase inhibitionon acetylcholine synthesisand release in (man), 301

Plasminogen activator, stimula-tion by prostaglandins (man),544

Platelet shape change, induced bythromboxane Ailprostaglan-

din H2 (man), 276Polyamines, role in tissue growth

and development (rats),741

Polyphosphoinositides

in brain, metabolism, involve-ment of alpha noradrenergicreceptors in mediation of(rats), 209

labeling increase by proprano-lol (rats), 109

Postnatal development, compari-son of maternal ethanol andmaternal t-butanol diet on

(mice), 294Potential (see specific name)

action, in myocardium, effectsof enflurane (guinea pigs),405

Potentialsaction, slow, in embryonic yen-

tnicles, sensitivity to metha-

choline (chicks), 383

action, slow, in skeletal muscle,effects of bepridil and vera-pamil on (frogs), 80

resting and action, in soleusmuscle, effect of ouabain on(rats), 401

Powell, R S., see Yount, E. A.,

501Pratila, M. G., see Lynch, C., III,

405

Prazosin, effect on clonidine-in-duced sleeping time (chicks,rats), 680

Primidone, effect on nerve-evoked transmitter releaseat neuromuscular junction(frogs), 87

Privitera, P. J., Walle, T. andGaffney, T. E.: Nicotinic-like

effects and tissue dispositionof isopropylamine, 116

Propranololeffects on ischemic myocardial

pH, comparison with dilti-azem (dogs), 720

effects on norepinephrine-evoked neurons! firing inmesencephalic reticular for-mation (rats), 555

effects on phospholipid metab-olism (rats), 109

1982 Index 795

(R)- and (S)-, in liver micro-somes, oxidation of (man,dogs), 458

interaction with phenobarbital(dogs), 589

role on ischemic blood flow andstenosis resistance (dogs), 635

Prostaglandin

E1 , E� and 12, stimulation of

fibrinolytic activity by (man),544

E2 , -induced fever, role of nor-epinephrine-cycic AMP linkon (rats), 251

12, biosynthesis, renal, relation-ship with renin release(dogs), 410

6-keto-F,,, secretion in kidney(dogs), 410

effect on pancreatic blood flowand exocrine excretion(dogs), 623

role in beta adrenoreceptor-stimulated resin release(dogs), 414

synthesis, medullary, effects ofdiuretics on (rats), 306

Prostaglandins, mediation ofendotoxin-induced pulmo-

nary hypertension (baboons),

441Protein binding, of vancomycin,

effect offurosemide (rabbits),237

Prozialeck, W. C. and Weiss, B.:Inhibition of CalmOdUIin by

phenothiazines and relateddrugs: Structure-activity re-lationships, 509

Purinoreceptors, inhibitory effectin modulation of adrenergic

neurotranamission (rats), 344

2-Pynidylethylamine, effect onhistamine-induced adreno-corticotropin hormone re-lease (rats), 583

Quinidine

effect on renal clearance of di-goxin (dogs), 49

mechanism of action on heartrate (dogs, guinea pigs), 688

[3H]Quinucidinyl benzilate, bind-ing sites in dentate gyrus, ef-fect of kindled seizures on(rats), 670

Ramey, E., see Myers, A., 315Ramwell, P., see Myers, A., 315

Ramwell, P. W., see Casey, L C.,441

Raphe, dorsal, nucleus, effects of

alpha-i and alpha-2 antago-nista on (rats), 287

Rapoport, R. M. and Bevan, J. A.:Increased contractility in-duced in rabbit ear artery byprior exposure to serotoninmasks concomitant desensi-tization to norepinephrmne,

338

Rauwoiscine, inhibition of clom-dine-induced sleeping timeby (chicks, rats), 680

Read, G. W., Hong, S. M. andKiefer, E. F.: Competitive in-

hibition of48/80-induced his-tamine release by benzalko-

nium chloride and its analogsand the polyamine receptorin mast cells, 652

Receptoracetylcholine, block by strep-

tomycin (frogs), 488alpha adrenergic, effect on

phosphatidylinositol labeling

and contraction in aorta (rab-bits), 258

beta adrenergic, developmentin heart (mice), 7

/3-endorphin, on vas deferens,studies on structural prereq-

uisites for activation of (rats),262

polyamine, inhibition of hista-

mine release (rats), 652Receptors

alpha adrenergic, in mesen-cephalic reticular formation,

characteristics of (rats), 555alpha-i and alpha-2 adrener-

gic, interactions of imidazo-

lines (guinea pigs), 29alpha noradrenergic, involve-

ment in mediation of brainpolyphosphoinositide metab-olism (rats), 209

alpha-2 adrenergic, stereoselec-

tivity of (guinea pigs), 645beta adrenergic, in pineal gland,

effect on elevation of mela-tonin (rats), 534

beta adrenergic subtype, onastroglia, identification of(rats), 600

kappa opiate, in ileum, effect ofdynorphin (guinea pigs), 71

nicotinic, effects of d-mcotineand i-isomer on (rats), 463

opiate, affinity of morphine invivo (rats), 198

opiate, in brain, effect ofethanol (mice), 182

opiate, method for extractingfrom brain (rats, cows, man,chickens, toads), 629

serotonin, antagonism of ketan-senin by (rats), 227

sigma, mediation of phencyci-dine and narcotic derivatives(rats), 146

Receptor binding, beta adrenergicand serotonin2, in brain, ef-fects of adrenocorticotropinhormone and yohimbine on(rats), 566

Reflex, righting, ketamine-in-duced loss, potentiation bycocaine (mice), 122

Reilly, M. A. and Sigg, E. B.: Sup-pression of histamine-in-duced adrenocorticotropinhormone (ACTH) release byantihistamines and antide-pressants, 583

Renin-angiotensin system, brain,effect ofconjugated estrogenson (rats),726

Resinrelease, beta adrenoceptor-

stimulated, effects of indo-methacin on (dogs), 414

release m kidney, relationshipwith prostaglandin 12 (dogs),410

release, role of beta adrenocep-

tor subtypes on (dogs), 606

Rentz, J., see Anderson, W., 617Richter, J. A. and Gormley, J. M.:

Inhibition of high affinitycholine uptake in the hippo-campus: Studies on the siteof pentobarbital action, 778

Roach, A. G., Lef�evre-Borg, F.,Gomeni, R. and Cavero, I.:Pharmacological evidence fa-

voring a similarity betweenalpha adrenoceptors mediat-

ing sleep in chicks and car-diac presynaptic alpha-2 re-ceptors in rats, 680

Rodgers, K., see Cherian, M. G.,699

Roeske, W. R., see Chen, F.-C. M.,7

Rowell, P. P., see Leventer, S. M.,

301Ruffolo, R. R., Jr. and Waddell, J.

E.: Receptor interactions ofimidazolines. IX. Cirazoline isan alpha-i adrenergic ago-nist and an alpha-2 adrener-gic antagonist, 29

Ruffolo, R R, Jr., Yaden, E. Land Waddell, J. E.: Stereo-chemical requirements of al-pha-2 adrenergic receptors,645

Russo, H. F., see Blaine, E. H.,

152

Rustum, Y., see Ellens, H., 324

Sastrasinh, M., Knauss, T. C.,Weinberg, J. M. and Humes,H. D.: Identification of theaminoglycoside binding sitein rat renal brush bordermembranes, 350

Savage, D. D. and McNamara, J.

0.: Kindled seizures selec-tively reduce a subpopulationof [3H]quinucidinyl benzi-late binding sites in rat den-tate gyms, 670

Schanberg, S., see Soukup, J., 209Schmoeker, P. F., see Cicero, T.

J., 20Schorn, T. W., see Blame, E. H.,

152Schuster, C. R., see Foltin, R. W.,

126

Scopolamine, effect on fixed-in-terval responding (squirrelmonkeys), 215

Secretiongastric, effect of prostaglandin

endoperoxide analog (mon-keys), 379

gastric, effects of methionine-enkephalin, morphine andnaloxone on 2-deoxy-D-glu-cose-induced vagal stimula-tion of (dogs), 617

of exocrine in pancreas, effectof prostaglandins (dogs),623

of renal resin, effect of sodiumorthovanadate (dogs), 447

Seidler, F. J., see Slotkin, T. A.,741, 746

Seiger, A., see Palmer, M. R., 480Seizures

kindled, effect on [3H]quinuci-dinyl benzilate binding sites(rats), 670

sound induced, effects of drug-induced increments in centralnervous system biogenicamine levels on (rats), 662

Sellers, B. M., see Ku, D. D., 395

Serotonin (see also 5-Hydroxy-tryptamine)

brain, release, effect of citalo-

pram on inhibition by lys-ergic acid diethylamide(rats), 220

effect on contraction in ear ar-tery (rabbits), 338

involvement in blood pressurecontrol (cats), 94

vagally mediated release, effect

of thyrotropin-releasing hor-mone on (rabbits), 367

Sexual differentiation, of arachi-

donate toxicity (mice), 315

Shannon, H. E.: Pharmacologicalanalysis ofthe phencycidine-like discriminative stimulusproperties of narcotic deriva-tives in rats, 146

Shannon, H. E. and Degregorio,

C. M.: Self-administration ofthe endogenous trace amines$-phenylethylamine, N-methyl phenylethylamineand phenylethanolamine indogs, 52

Shea-Donohue, P. T., Nompleggi,D., Myers, L and Dubois, A.:

A prostaglandin endoperox-ide analog increases gastricemptying and suppresses gas-tric secretion in rhesus mon-keys, 379

Sigg, E. B., see Reilly, M. A., 583Simon, E. J., see Howells, R D.,

629Simpson, L L: The interaction

between aminoquinolinesand presynaptically actingneurotoxins, 43

Simpson, L L: Disulfide bond re-

duction inhibits norepineph-rine accumulation in post-

ganglionic sympathetic nerve

endings, 419

Skin fibroblasts, effects of pros-taglandins on fibninolytic ac-

tivity in (man), 544

SL-76002, effect on dopamine

metabolism in nigrostriatalpathway (rats), 674

Sleep, ketamine-induced, poten-tiation by cocaine (mice), 122

Slopis, J., see Kendall, D. A., 566

Slotkin, T. A., Grignolo, A., Whit-more, W. L., Lerea, L., Tre-panier, P. A., Barnes, G. A.,Weigel, S. J., Seidler, F. J.and Bartolome, J.: Impaireddevelopment of central andperipheral catecholamineneurotransmitter systems inpreweanling rats treated with

796 Index

a-difluoromethylornithine, a

specific irreversible inhibitorof onnithine decarboxylase,746

Slotkin, T. A., Seidler, F. J., Tre-panier, P. A., Whitmore, W.L., Lerea, L., Barnes, G. A.,Weigel, S. J. and Bartolome,J.: Ornithine decarboxylaseand polyamines in tissues ofthe neonatal rat: Effects of

a-difluoromethylornithine, aspecific, irreversible inhibitor

of ornithine decarboxylase,

741Smith, T. W., see Wolf, R. A., 331

Snyder, C., see Blaine, E. H., 152Sodium orthovanadate, effect on

renal renin secretion (dogs),447

Sodium pump, myocardial, effectsof streptozotocin diabetes

and insulin treatment on

(rats), 395

Sorensen, S. M., see Palmer, M.

R., 480Soukup, J. and Schanberg, S.: In-

volvement of alpha noradre-nergic receptors in mediationof brain polyphosphoinosi-tide metabolism in vivo, 209

Spector, R.: Pharmacokineticsand metabolism of cytosinearabinoside in the centralnervous system, 1

Sperelakis, N., see Kerr, L. M., 80

Sperelakis, N., see Lynch, C., III,405

Sperelakis, N., see Vogel, S., 383Spleen, distribution and metabo-

barn of lipsome-encapsulatedand free i-/3-D-arabinofura-nosylcytosine in (dogs, mice),324

Spoerlein, M. T., see Vander-

wende, C., 122

SQ 14,225, angiotensin I convert-ing enzyme inhibitor, hype-

tensive action of (dogs), 246Stefano, G. B., Zukin, R S. and

Kream, R M.: Evidence forthe presynaptic localization

of a high affinity opiate bind-

ing site on dopamine neurons

in the pedal ganglia of Muti-lus esulis (Bivalvia), 759

Stimulationalpha and beta adrenergic, of

18-endorphin release from pi-tuitary (rats), 103

electrical, of serotonin releaseby lysergic acid diethylamine

(rats), 220isotropic, in left atrium and

ventricle, effects of verapamilon (dogs), 270

nerve, sympathetic, radial an-tery, effects of cocaine and17-fl-estradiol on (cows),

731

of p-aminohippurate by vera-

pamil (rats), 452of cellular fibrinolytic activity

by prostaglandins (man), 544

of prostaglandin synthesis by

diuretics (rats), 306

Stomacheffect ofprostaglandin endoper-

oxide analog on emptyingand secretion of (monkeys),379

influence of mu and delta opi-ates on vagal stimulation of

(dogs), 617

secretion and absorption of

basic drugs (rats), 372Streptomycin, mechanism of neu-

romuscular block by (frogs),488

Syndrome, fetal alcohol, effect of

ethanol (mice), 294

Tabakoff, B., see Hoffman, P. L.,182

Tachycardia, induced by quini-dine (dogs, guinea pigs), 688

Tai, C.-Y. and Jackson, M. J.:Transport of weak bases

across rat gastric mucosa invivo and in vitro, 372

Takahashi, H., Ashizawa, H.,Takeda, K., Yoneda, S.,

Yoshimura, M. and Ijichi, H.:Central vasopressor re-

sponses to conjugated estro-

gens in rats may be mediated

via a renin-angiotensin sys-tem in the brain, 726

Takeda, K., see Takahashi, H.,726

Takeda, K., Temma, K. and Ak-era, T.: Inotropic effects ofvanadate in isolated rat andguinea-pig heart under con-

ditions which modify calcium

pools involved in contractileactivation, i32

Talbot, P. A. and Aerice, M. T.:

Primidone but not phenyl-

ethylmalonamide, a majormetabolite, increases nerve-evoked transmitter release atthe frog neuromuscular junc-

tion, 87

Tallarida, R J. and Cowan, A.:The affinity of morphine forits pharmacologic receptor invivo, 198

Talseth, T., see Clementi, W. A.,159

Taylor, D. G., Taylor, K. A. andAntonaccio, M. J.: Pharma-cological studies on sympa-thoinhibition produced by

the medial medullary depres-

sor region: Proposed -y-ami-nobutynic acid involvementin inhibition of somatosym-pathetic reflexes, 517

Taylor, K. A., see Taylor, D. G.,517

Temma, K., see Takeda, K., 132

Testes, degeneration of germ

cells, effects of 2-chloropro-pionate on (rats, mice), 501

Testosterone, role in alcohol de-hydrogenase-dependent me-tabolism of ethanol (rats), 20

Tetanus toxin, effect of chloro-

quine (mice, rats, guinea pigs,chicks), 43

4,5,6,7-Tetrahydroisoxazolo-[5,4-

C]-pyridin-3-ol, effect on do-pamine metabolism in nigro-

striatal pathway (rats), 674

Tetrodotoxin, effect on 20,25-di-azacholesterol-induced my-otonia of skeletal muscle(rats), 401

Theophyffine, effect on acetylcho-line turnover rate in brain(rats), 550

Thiopurine methyltransferase,pharmacogenetics (man), 174

Thiosemicarbazide, inhibition of

y-aminobutynic acid synthe-sis by (cats), 517

Thompson, T. N., see Gregus, Z.,471

Threlkeld, P. G., see Wong, D. T.,61

Thrombin, endothelium-depend-ent effects in femoral artery(dogs), 166

Thromboxane A2/prostaglandin

H2-induced platelet shapechange (man), 276

Thromboxane B2, mediation ofendotoxin-induced pulmo-nary hypertension (baboons),

441Thymoxamine, effect on cloni-

dine-induced sleeping time(chicks, rats), 680

Thyrotropin releasing hormone

effects on gastrointestinal activ-

ity (rabbits), 66

effect on gastrointestinal transitand serotonin release (rab-bits), 367

Timmermans, P. B. M. W. M., see

de Jonge, A., 705, 712Timmermans, P. B. M. W. M., see

Kaikinan, H. 0., 227Tolazoline, antagonism of central

nervous adrenoceptors by(cats), 771

Tolerancebehavioral and cross-, to dl-

cathinone and d-amphet-

amine (rats), 126to morphine and enkephalins

(rats), 190Toxicity

amitniptyline-induced, action ofdiazepam and sympathomi-metic amines against (cats),424

nitrofurantoin-mediated red

cell, studies on mechanism on(man), 430

of arachidonate, sexual differ-

entiation (mice), 315of 2-chloropropionate and di-

chloroacetate (rats, mice),

501physostigmine-induced, protec-

tive effects of clomdine on

(mice), 595Trachea, effects of indomethacin

and meclofenamic acid onleukotriene-induced contrac-tions in (guinea pigs), 202

Transmissionneuromuscular, adrenergic, role

of nucleosides and nucleo-tides (rats), 344

of ‘y-aminobutynic acid in med-

Vol. 222

ullary pressor region (cats),

517

Transport

of acetylcholine in term pla-

cents, effect of choline ace-tyltransferase inhibition on(man), 301

ofhigh-affinity choline in brain,effect of ethyicholine mus-tard azinidinium ion (mice),140

of organic acids in kidney, stim-ulatory action of verapamilon (rats), 452

ofweak bases across gastric mu-

cons in vivo and in vitro(rats), 372

Trans-stilbene oxide, effect onmetabolism and biliary excre-tion of morphine (rats), 526

Trepanier, P. A., see Slotkin, T.A., 741, 746

Trifluopromazine, inhibition of

calmodulin by (rats), 509Tripelennamine, effect on hista-

mine-induced adrenocorti-

cotropin hormome release(rats), 583

Tritium, distribution in brainafter injection of [3H]cysto-sine arabinoside (rats), 765

Tsay, B. L., see Un, M. T., 251

Tsuru, M., Erickson, R R and

Holtzman, J. L: The metab-olism of phenytoin by iso-lated hepatocytes and he-patic microsomes from malerats, 658

Uc, M., see Villalobos-Molina, R,

258Uptake

choline, in hippocampus, inhi-

bition by pentobarbital(rats), 778

of norepinephrmne, in brain, in-

hibition by LY135252 (rats),61

Urea, metabolism, benzoate-in-duced changes in (man), 572

Urwyler, S., see Hoffman, P. L.,182

Vanadate, isotropic effects in iso-lated heart (rats, guineapigs), 132

Vancomycin-furosemide interac-tions (rabbits), 237

Vanderwende, C., Spoerlein, M.

T., and Lapollo, J.: Cocainepotentiates ketamine-in-duced loss of the righting re-flex and sleeping time inmice. Role of catecholamines,122

Vanhoutte, P. M., see De Mey, J.G., 166

van Zwieten, P. A., see de Jonge,A., 705, 712

van Zwieten, P. A., see Kalkman,H. 0., 227

Vascoconstnictor response, to ad-renergic stimulation, modu-lation by nucleosides and nu-cleotides (rats), 344

Vas deferens, studies on struc-

1982 Index 797

tural prerequisites for acti-vation of fl-endorphin recep-tor on (rats), 262

Venton, D. L, see Parise, L V.,276

Ventricles, embryonic, sensitivity

of slow action potentials tomethacholine in (chicks), 383

Verapamil

effect on Ca4�-dependent slowaction potentials in skeletalmuscle (frogs), 80

effects on isotropic stimulationin left atrium and ventricle(dogs), 270

stimulatory action on transport

of organic acids in kidney(rats), 452

Villalobos-Molina, R., Uc, M.,Hong, E. and GarcIa-Silinz, J.A.: Correlation between

phosphatidylinositol labelingand contraction in rabbitaorta: Effect of alpha-i ad-renergic activation, 258

Vincristine, inhibition of[�H]thy-midine incorporation intoDNA (rats), 765

Vogel, S., see Linden, J., 383Vogel, S., see Lynch, C., Ill., 405von Bahr, C., Hermanason, J. and

Lind, M.: Oxidation of (R)-and (S)-propranolol in hu-man and dog liver micro-somes. Species differences instereoselectivity, 458

Vonvoigtlander, P. F., Kolaja, G.J. and Block, E. M.: Corneallesions induced by antide-pressanta: A selective effect

upon young Fischer 344 rats,282

Waddell, J. E., see Ruffolo, R. R.,Jr., 29, 645

Walle, T., see Privitera, P. J., 116

Wailer, L, see Pang, K. S., 14Warltier, D. C., see Gross, G. J.,

635

Warltier, D. C., see Zyvoloski, M.

G., 494Wasserman, M. A., see Weich-

man, B. M., 202

Watkins, J. B., see Gregus, Z., 471

Way, E. L., see Huidobro-Toro, J.P., 262

Way, E. L., see Yoshimura, K., 71

Weichman, B. M., Muccitelli, R.

M., Osborn, R R., Holden, D.

A., Gleason, J. G. and Was-serman, M. A.: In vitro andin vivo mechanisms of leu-

kotniene-mediated broncho-constriction in the guinea pig,202

Weigel, S. J., see Slotkin, T. A.,741, 746

Weinberg, J. M., see Sastrasinh,M.,350

Weinshilboum, R M., see Wood-son, L. C., 174

Weiss, B., see Prozialeck, W. C.,509

Whitmore, W. L., see Slotkin, T.

A., 741, 746

Wolf, R A., Chaung, L.-Y.,O’Hara, D., Smith, T. W. and

Muller, J. E.: The serum ki-netics ofbovine testicular hy-

aluronidase in dogs, rats and

humans, 331Wong, D. T., Threlkeld, P. G.,

Best, K. L and Bymaster, F.P.: A new inhibitor of norepi-nephnine uptake devoid of a!-finity for receptors in rat

brain, 61Wood, P. L.: Actions of GA-

BAergic agents on dopaminemetabolism in the nigrostri-atal pathway of the rat, 674

Woodson, L. C., Dunnette, J. H.and Weinshilboum, H. M.:Pharmacogenetics of humanthiopurine methyltransfer-

ase: Kidney-erythrocyte cor-relation and immunotitration

studies, 174Wu, C. H., see Farley, J. M., 488Wu,J.J.,seeLin,M.T.,251

Xylazine-induced sleep time, in-

hibition by alpha-2 adreno-ceptor antagonists (chicks,rats), 680

Yaden, E. L, see Ruffolo, R R,

Jr., 645Yamamoto, K., see Miura, K., 246Yamamura, H. I., see Chen, F.-C.

M., 7

Yohimbine

effect on clonidine-induced pro-tection of physostigmine tox-icity (mice), 595

influence on antidepressant-in-

duced decline in brain neu-rotransmitter receptor bind-

ing (rats), 566inhibition of clonidine-induced

sleeping time by (chicks,rats), 680

Yokotani, Y. S. K., see Ikushima,S., 463

Yoneda, S., see Takahashi, H., 726Yoshimura, K., Huidobro-Toro, J.

P., Lee, N. M., Loh, H. H.

and Way, E. L.: Kappa opioidproperties of dynorphin andits peptide fragments on theguinea-pig ileum, 71

Yoshimura, M., see Takahashi,H., 726

Yount, E. A., Felten, S. Y.,O’Connor, B. L, Peterson, R.G., Powell, R S., Yum, M. N.and Harris, R A.: Compari-son ofthe metabolic and toxiceffects of 2-chloropropionateand dicb.loroacetate, 501

Yum, M. N., see Yount, B. A., 501

Zimmerman, J. B., see Jackson,

E. K., 414Zelis, R., see Flaim, S. F., 359Zmudka, M. I., see Casey, L C.,

441Zukin, H. S., see Stefano, G. B.,

759Zyvoloski, M. G., Brooks, H. L,

Gross, G. J. and Warltier, D.C.: Myocardial perfusion dis-tel to an acute or chronic cor-onary artery occlusion: Ef-fects of diltiazem and nifedi-pine, 494