THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright C 1972 by The Williams & Wilkins Co.vol. 182, No. 3
Printed in U.S.A.
Volume 182, July-September 1972
533
INDEX
Acara, M. and Rennick B. : Renal tubular trans-
port of aeetylcholine and atropiae : Enhance-meat and inhibition, 14
Acara, M. and Rennick, B. : Renal tubular trans-
port of choline : Modifications caused byintrarenal metabolism, 1
Acetylation method, sensitive assay for hepatie
N-demethylation of chioreyclizine in vitro,
312Acetyleholine
acetyicholine mustard and, comparison of
action on muscarime and iucotinie receptors,
303atropine and, renal tubular transport, enhance-
meat and inhibition, 14-induced smooth muscle contraction, effect of
ouabain, 378Acetyleholine mustard , (chloroethylmethylami-
noethyl acetate) , acetylcholine and, compari-son of action on muscarinic and nicotinic
receptors, 303Action potential, of squid giant axons, blockade
by allethrin, mechanism of negative tem-
perature coefficient, 442Adenosine triphosphatase, effect on uptake of
ouabain by rabbit myometrium, 166Adrenergic drugs
sterie aspects, accumulation of (-)- and
(+)-norepinephrine-”C by peripheral tissuesof rat, 273
steric aspects, influence of various factors onstereoseleetivity of pre- and postjunetioaalsites to norepinephrine isomers in isolatedrat vasa deferentia, 101
Adrenergic neurons, in perfused guinea-pig heart,
mechanism of action of nicotine in, 454Adrenergic receptor
alpha , activity and melanophore stimulatinghormone action �n melanophores , sulfhydryl
requirement, 93beta, blockade in rat, 256
Adriamyeindaunomycin and, identification of new metab-
olites of, 70
daunomycin and, metabolism via reductiveglycosidic cleavage, 63
Agid, Y., see Javoy, F., 454
Akerman, S. B. A., see Ross, S. B., 351Alcohol, marihuana and, comparison of effects on
temporally controlled operant in humans, 195
Allethrin, nerve blocking action, mechanism of
negat ive temperature coefficient, 442Amatuzio, D. S., Bates, H. A. and Hay, L. J.:
Observations on the interactions of protaminewith mouse whole blood components, 528
Aminoguanidine, quinidine and, effect on hista-mine levels in rat and rabbit blood vessels,239
Amphetamine-induced release of norepinephrine
from rat cerebral cortex in vitro, characteris-
tics, 284
d-Amphetamine, as cause of anorexia in rats, 464
Anesthetic effect, local, of three N-w-haloalkyl-N-methylaminoaceto-2,6-xylidide derivatives,
cyelization in relation to, 351Aniline, effect on reserpine metabolism in vitro,
500Anorexia, in rats, induced by SK&F 1-39728,
fenfiuramine and (I-amphetamine, 464Antihypertensive agents (methyldopa , hydrala-
zine and guanethidine), contribution ofcentral nervous system to action of, 135
Anti-inflammatory drugs, steroidal and iionste-
roidal, effects on integrity in vivo of rat liver
lysosomes, 179Antimalarial drug
4,4’-diformamidodiphenylsulfone, pharmacol-
ogy in dog and monkey, 34
4,4’-diformamidodiphenylsulfone, pharmacol-ogy in man, 48
Antimitotic compounds, ability to inhibit rathindpaw edema, 344
Aorta, rat, contractile responses to norepineph-rine and tyramine, 264
Arrhythmias , cardiac , digi talis-induced, sup-pression by clonidine, 218
Asbell, M. A., Schwartzbach, E., Bullock, F. J.
and Yesair, D. W. : Daunomycin andadriamycin metabolism via reductive gly-
eosidie cleavage, 63Asbell, M. A., see Bullock, F. J., 70
Atriaguinea pig, in vitro effects of Rb 7-2956, 399rat, responses to isoproterenol, effects of
propranolol, practolol and butoxamine, 256Atropine
acetylcholine and , renal tubular transport,
enhancement and inhibition, 14effects on cardiovascular function in squirrel
monkey during behavioral experiments, 204
534 INDEX
ylalanine, 155
Brasted, M., see Westfall, T. C., 409
effects 011 ouabain-induced changes in automa-
ticity of blood-perfused canine papillary
muscle, 388
Axelrod, J.see Molinoff, P. B., 116
see Saavedra, J. M. , 363
Azzaro, A. J., see Ziance, It. J. , 284
Bartl, P., see Dalton, C., 491Bates, H. A., see Amatuzio, 1). 8., 528Baum, T. , Shropshire, A. T. and Varner, L. L.:
Contribution of the central nervous system to
the action of several antihypertensive agents
(methyldopa, hydralazine and guanethidine),
135
Bend, J. it, see hook, (. E. IL, 474Bevan, J. A. and Su, C. : Uptake of nicotine by the
sympathetic nerve terminals in the blood
vessel, 419
Benzphetamine N-demethylase , concent rations i a
rabbit lung and liver subeellular fractions,
4741-Benzyl-�1-methoxy-3-trifluoromet hylphenethyla-
mine, see SK&F 1-39728Betaine, intrarenal metabolism of choline to, 1Bile, formation itt sheep, dogs, rats, guinea pigs
and rabbits, effect of ethacrynic acid, 27Biphenyl 4-hydroxylase , concentrat ions in rabbit
lung and liver subcellular fractions, 474
Blehm, I). J., see Johnson, E. M., Jr., 56
Blood, whole, components, mouse, interactionswith protamine, 528
Blood pressurein squirrel monkey during behavioral experi-
meats, effects of propranolol, phentolamineand methyl atropine, 204
spontaneous running activity , salt appetite
and, in ovariectomized rats, effect of oral
contraceptive, 335
Blood vessel(s)
mammalian, disposition of histamine, 239
uptake of nicotine by sympathetic nerve ter-
minals in, 419
Borzelleca, J. F., see Putney, J. W., Jr., 515
Bouvet, D., see Javoy, F., 454
Bradykinin-induced smooth muscle contraction,
effect of ouabain, 378
Braincat, effects of 2,5-dimethoxy-4-methylamphet-
amine on, 145
rat, assay for tryptamine in, 363
rats, monoamine stores, effects of SK&F 1-39728,
fenfluramine and d-amphetainine , 464serotonin turnover, in morphine tolerant-
dependent mice, influence of p-chlorophen-
Bretyliumeffect oti activity of dopamine-�-hydroxylase
and tyrosine hydroxylase in rat hearts and
ganglia, 116effects on nicotine-induced changes in perfused
guinea-pig heart, 409Brimijoin, S., see Molinoff, P. B., 116Bruni, H. J., see Bullock, F. J., 70Buckley, J. P., see Kline, R. L., 399Bullock, F. J., Bruni, H. J. and Asbell, M.
A. : Identification of new metabolites ofdaunomvcin and adriamycin, 70
Bullock, F. J., see Asbell, M. A., 63Butoxamine, effect on responses to isoproterenol
of rat uterus, atria and fundus, 256N-t-Butylnorchlorcyclizine, in vivo and in vitro
N-dealkylation to norchlorcvclizine by rat,
507
Calcium, serum, concentration in rats, effect of
urethane, 522Caple, I., see Shaw, H., 27Cappell, H., Webster, C. D., Herring, B. S. and
Ginsberg, R. : Alcohol and marihuana : Acomparison of effects on a temporally con-
trolled operant in humans, 195Cardiac glycosides, uptake by rabbit and rat
myometrium, 166
Cardiovascular function , in squirrel monkey
during behavioral experiments, effects of
propranolol, phentolamine arid methyl atro-pine, 204
Catecholaminesbinding to human serum albumin, 295
depletion, effect on activity of dopamine.$-hydroxylase and tyrosine hydroxylase in rat
hearts and ganglia, 116glucose release from rabbit liver slices induced
by, antagonism by propranolol and phentol.
amine, 370Cat(s)
neuropharmacological examination of 2,5-
dimethoxy-4-methylamphetamine in, 145suppression by clonidine of digitalis-induced
cardiac arrhythmias, 218sympathetic nervous system, effect of chronic
treatment with pargyline and l-dopa, 130Central nervous system
contribution to action of several antihyper-
tensive agents (methyldopa, hydralazineand guanethidine), 135
neurons, release of norepinephrine from, 284Cerebral cortex, rat, characteristics of in vitro
amphetamine-induced release from , 284
Chan, P. S., see M#{252}hlbachov#{225},E., 370Cheney, D. L., Judson, B. A. and Goldstein, A.:
Failure of an opiate to protect mice against
naloxone-precipitated withdrawal, 189
535
and liver suhcellular fractions, 474
INDEX
Chickenenhancement and inhibition of renal tubular
transport of acetylcholine and atropine, 14
modifications iii renal tubular transport of
choline caused by ilitrarenal metabolism, 1Chlorcyclizine, hepatic N-demethylation in
vitro, sensitive assay for, 312Chloroethylmethylami noethyl ace tate , see Ace-
tyicholine mustard
p-Chlorophenylalanine , influence OIl morphinetolerance and physical dependence and re-gional brain serotonin turnover in morphine
tolerant-dependent mice, 155
Choline , renal tubular transport , modificat ionscaused by intrarenal metabolism, 1
Clonidine (St-155) , suppression of digitalis-in-
duced cardiac arrhythmias, 218
Cocaineeffect on accumulation of norepinephrine isomers
in rat vasa deferentia, 101effects OR nicotine-induced changes in perfused
guinea-pig heart, 409effects on nicotine uptake in rabbit aortic strip,
419isomers, effect on uptake of (-)- and (+)-nor-
epinephrine-”C by rat peripheral tissues, 273pretreatment, influence on effects of norepi-
nephrine and tyramine on rat aorta, 264
Coichicine, derivatives, correlation of antimitoticactivity with inhibition of sodium tirate-
induced rat hindpaw edema, 344
Compound 48/80, effect on histamine levels inrat and rabbit blood vessels, 239
Cooper, C. W. , see Peng, T.-C. , 522Costa, E., see Groppetti, A., 464Cytochrome P-450, concentrations in rabbit lung
Dalton, C., Kamm, J. J. and Bartl, P. : 5,5’-l)i-phenyl-2-thiohydantoin (1)PTH) : An inducer
of microsomal drug-metabolizing enzymes,491
Daniel, E. E., see Murthy, R. V. , 166
Danon, A. and Sapira, J. D. : Binding of cate-cholamines to human serum albumin, 295
I)aunomyci n
adriamycin and, identification of new metab-olites of, 70
adriamycin and, metabolism via reductive
glycosidie cleavage, 63N-Dealkylation, in vivo and in vitro, of N-t-bu-
tylnorchlorcyclizine to norchlorcyclizine by
rat, 507N-Demethylation, hepatic, of chlorcyclizine
in vitro, sensitive assay for, 312
Desipramineeffects on nicotine uptake in rabbit aortic strip,
419
pretreatment, influence on effects of norepi-
aephrine and tyramine on rat aorta, 264l)eslanoside-induced cardiac arrhythmias , sup-
pression by clonidine, 2184, 4’-Diaminodiphenylsulfone, role of 4 , 4’-di-
formamidodiphenyisulfone it dog and monkeyin relation to, 34
Dibenamine, action on melanophores of lizard, 934,4’-Diformamidodiphenylsulfone
antimalarial drug, pharmacology in dog and
monkey, 34, 48antimalarial drug, pharmacology in man, 48
Digitalis-induced cardiac arrhythmias, suppres-
sion by clonidine, 218
Digitoxin, uptake by rabbit and rat myometrium,
166
4-(3,4-Dimethoxybenzyl) -2 -imidazolidinone, see
Ro 7-2956
2,5 - Dimethoxy -4 - methylamphetamine, neuro-pharmacological examination , 145
Dionne, H. A., see Gillis, H. A., 2185,5’-Diphenylhydantoin, as inducer of microsomal
drug-metabolizing enzymes , comparison with5,5’-diphenyl-2-thiohydantoin, 491
5 ,5’-Diphenyl-2-thiohydantoin, inducer of mi-
crosomal drug-met abolizing enzymes , 491
Dogblood-perfused papillary muscle preparation,
automaticity in, effects of therapeutic and
toxic doses of ouabain, 388
effects of norepinephrine and propranoiol onmyocardial subcellular distribution of t ri-glycerides and free fatty acids, 246
man and, mass spectrometric identification ofsix new metabolites of propranolol in, 83
modifications in renal tubular transport of
choline caused by intrarenal metabolism, 1monkey and, pharmacology of antimalarial
drug 4,4’-diformamidodiphenylsulfone in, 34
sheep, rats, guinea pigs, rabbits and, effect of
ethacrynic acid on bile formation in, 27Dopa, effect on activity of dopamine-fi-hydrox-
ylase and tyrosine hydroxylase in rat hearts
and ganglia, 116l-Dopa, pargyline and, chronic treatment, effect
on sympathetic nervous system, 130
Dopamineamphetamine-induced release from rat cerebral
cortex, 284brain, effect of 2,5-dimethoxy-4-methylam-
phetamine on, 145
concentrations in rat brain, effects of SK&F
1-39728, fenfluramine and d-amphetamine, 464synthesis in dopaminergic terminals of rat
striatum, feedback control, 454Dopamine-fl-hydroxylase, tyrosine hydroxylase
and, induction in rat hearts and sympathetic
ganglia, 116
536 INDEX
351
Edema, sodium urate-induced, in rat hindpaw,inhibition by colchiciae derivatives correlated
with antimitotic activity, 344Ellis, S., see M#{252}hlbachov#{225},E., 370Endoh, M., see Hashimoto, K., 388End-plate membranes, mechanisms of dual action
of nicotine, 427
Enovid, effect on spontaneous running activity,
salt appetite and blood pressure of ovariec-
tomized rats, 335Enzymatic assay, specific and sensitive, for
tryptamine in tissues, 363
Enzymesdistribution , comparison between subcellular
fractions of rabbit lung and liver, 474
drug-metabolizing, microsomal , induced by5 ,5’-diphenyl-2-thiohydantoin, 491
extrusion from lysosomes, effects of anti-in-flammatory drugs, 179
Epinephrinebinding to human serum albumin, 295-induced glucose release from rabbit liver slices,
antagonism by propranolol and phentolamine,
370Erythrityl tetranitrate, degradation by rat liver,
56Ethacrynic acid, effect on bile formation in sheep,
dogs, rats, guinea pigs and rabbits, 27Ethylmorphine N-demethylase, activity in rat
liver, effect of 5 , 5’-diphenyl-2-thiohydantoin,
491Ethynodiol diacetate , norethindrone , progester-
one and, whole body distribution in pregnant
mouse, 328
Fenfluramine, as cause of anorexia in rats, 464Fouts, J. R., see Hook, G. E. B., 474Free fatty acids, triglycerides and, myocardial
subcellular distribution, effects of norepi-nephrine and propranolol , 246
Fregly, M. J. : Effect of an oral contraceptive onspontaneous running activity, salt appetiteand blood pressure of ovariectomized rats, 335
Freudenthal, B. I., Martin, J. and Wall, M. E.:The whole body distribution of norethindrone,
ethynodiol diacetate and progesterone in thepregnant mouse, 328
Friedman, E., see Wallach, M. B., 145
Frog
rectus abdominus preparations, comparison ofact ions of acetylcholine and acetylcholine
mustard on, 303
sartorius muscle end-plate membranes, mecha-nisms of dual action of nicotine, 427
sciatic nerve, cyclization of three N-w-haloalkyl-N-methylaminoaceto-2,6-xylidide derivativesin relation to their local anesthetic effect in,
Fundus, rat, responses to isoproterenol, effects
of propranolol, practolol and butoxamine, 256
Gaffney, T. E., see Walle, T., 83Gershon, S., see Wallach, M. B., 145Gillis, R. A., Dionne, 11. A. and Standaert, F. G.:
Suppression by clonidine (St-155) of cardiac
arrhythmias induced by digitalis, 218Ginsberg, H., see Cappell, H., 195
Glaviallo, V. V., see Masters, T. N., 246
Glowinski, J., see Javoy, F., 454Glucose, release from rabbit liver slices induced
by catecholamines, antagonism by pro-pranolol and phentolamine, 370
Glyceryl trinitrate, degradation by rat liver, 56
Glycosides, cardiac, uptake by rabbit and rat
myometrium, 166Goldman, J. M. and Hadley, M. E. : Sulfhydryl
requirement for alpha adrenergic receptoractivity and melanophore stimulating hor-
mone (MSH) action on melanophores, 93Goldstein, A., see Cheney, D. L., 189
Gram, T. E., see Hook, G. E. II., 474
Griffin, J. D., Szaro, 11. P. and Weltmaii, J. K.:Ouabain antagonism of smooth muscle con-
traction, 378Grollman, A., see Krishnamurty, V. S. II., 264
Groppetti, A., Misher, A., Naimzada, M.,Revuelta, A. and Costa, E. : Evidence that inrats 1-benzyl-$-methoxy-3-trifluoromethyl-
phenethylamine (SK&F 1-39728) dissociatesanorexia from central stimulation and actions
on brain monoamine stores, 464Guanethidine
effects on mcotine uptake in rabbit aortic strip,
419methyldopa , hydralazine and , antihypertensive
agents, contribution of central nervous system
to action of, 135
pretreatment, effect on accumulation of (-)-
and (+)-norepinephrine-”C by rat peripheral
tissues, 273
Guinea pig(s)
atria, in vitro effects of Ho 7-2956, 399
heart, isolated, quantitative comparison of
effects of exogenous and immunologicallyreleased histamine on, 227
intestinal smooth muscle, contraction, antago-
aism by ouabain, 378
perfused heart, adrenergic neurons, mechanism
of action of nicotine in, 409
sciatic nerve, cyclization of three N-w-haloalkyl..
N-methylaminoaceto-2,6-xylidide derivatives
in relation to their local anesthetic effects in,
351
sheep, dogs, rats, rabbits and, effect of
ethacrynic acid on bile formation in, 27
537INDEX
Hadley, M. E., see Goldman, J. M., 93
N-w-Haloalkyl-N-methylaminoaceto-2,6-xylidide,
derivatives, cyclization in relation to their
local anesthetic effect, 351
Harkey, A. B., see Johnson, E. M., Jr., 56Hashimoto, K., Kimura, T. and Endoh, M.:
Effects of therapeutic and toxic doses ofouabain on automaticity in the blood-perfused
canine papillary muscle preparation, 388Hay, L. J., see Amatuzio, D. S., 528
Heart(s)digitalis-induced arrhythmias, suppression by
clonidine, 218
isolated, quantitative comparison of effects of
exogenous and immunologically released
histamine on, 227perfused, guinea-pig, adrenergic neurons, mech-
anism of action of nicotine in, 409rat, sympathetic ganglia and, induction of
dopamiae-fl-hydroxylase and tyrosine hy-droxylase in, 116
Heart rate, in squirrel monkey during behavioral
experiments, effects of propranolol, phentol-
amine and methyl atropine, 204Heath, T., see Shaw, H., 27
Herd, J. A., see Kelleher, II. T., 204
Herring, B. S., see Cappell, H., 195
Hexamet honium
effects on nicotine-induced changes in perfused
guinea-pig heart, 409effects on nicotine uptake in rabbit aortic strip,
419
Hexobarbital, effect on reserpine metabolism in
vitro, 500
H indpaw , edema , rat , sodium urate-induced,inhibit 1011 by colchicine derivatives correlatedwith ant imitotic activity , 344
Histamine
disposition in mammalian blood vessels, 239
exogenous and immunologically released, quaIl-
titative comparison of effects on isolatedheart, 227
-induced smooth muscle contraction, effect ofouabain, 378
Ho, I. K., Lu, S. E., Stolman, S., Loh, H. ii., and Way,E. L. : Influence of p-chlorophenylalanine on
morphine tolerance and physical dependenceand regional brain serotonin turnover studies
in morphine tolerant-dependent mice, 155
Hoel, D., see Hook, Cl. E. H., 474
Hook, G. E. H., Bend, J. H., Hoel, D., Fouts, J.
H. and Gram, T. E. : Preparation of lung
microsomes and a comparison of the distri-bution of enzymes between subcellular frac-
tions of rabbit lung and liver, 474lowland, H. D. and Spector, S. : Disposition of
histamine iii mammalian blood vessels, 239
Hudgins, P. M. and Stubbins, J. F. : A comparison
of the action of acetylcholine and acetyl-choline mustard (chloroethylmethylamino-
ethyl acetate) on muscarinic and nicotinicreceptors, 303
Hydralazine , met hyldopa , guanethidine and,
aatihypertensive agents , contribution ofcentral nervous system to action of, 135
Hydrocortisone, capacity to alter in vivo integrity
of rat liver lysosomes, 1796-Hydroxydopamine
effect on accumulation of norepinephrine
isomers in rat vasa deferentia, 101pretreatment , effects on nicotine-induced
changes in perfused guinea-pig heart, 409
pretreatment, influence on effects of norepi-
nephrine and tyramine on rat aorta, 264
Hypocalcemia, caused by urethane in rats, 522Hypotension, after prolonged treatment with
pargyline or l-dopa, cause, 130
Ignarro, ii. J. : Lysosome membrane stabilizationin vivo : Effects of steroidal and nonsteroidalanti-inflammatory drugs on the integrity of
rat liver lysosomes, 179Infrared spectroscopy, use in identification of
metabolites of daunomycin and adriamycin,
70
Iproniazid, pretreatment, effect on accumulation
of (-)- and (+)-norepiaephrine-”C by rat
peripheral tissues, 273Isomers
of norepinephrine, accumulation by rat periph-eral tissues, 273
of norepiriephrine in isolated rat vasa deferentia,influence of various factors on stereoselec-
tivity of pre- and postjunctional sites to, 101Isoprotereriol
-induced glucose release from rabbit liver slices,antagonism by propranolol and phentol-
amine, 370responses of rat uterus, atria and fundus to,
antagonism by propranolol , practolol andbutoxamine, 256
Isosorbide dinitrate, degradation by rat liver, 56
Jacobson, M. M., Tsai, I., Poland, A. and
Kuntzman, H. : A sensitive assay for thehepatic N-demethylation of chlorcyclizine in
vitro, 312
Javoy, F., Agid, Y., Bouvet, D. and (ilowiaski, J.:
Feedback control of dopamine synthesis in
dopaminergic terminals of the rat striatum,
454
Johnson, E. M., Jr., Harkey, A. B., Blehm, D. J.
and Needleman, P. : Clearance and metabo-
lism of organic nitrates, 56
Judson, B. A., see Cheney, D. L., 189
538 INDEX
Kamm, J. J., Szuna, A. and Kuntzman, H. : Studies
on an unusual N-dealkylation reaction. I.
In vivo and in vitro N-dealkylation of N-I-
butylchlorcyclizine to norchiorcyclizine bythe rat, 507
Kamm, J. J., see Dalton, C., 491
Kelleher, II. T., Morse, W. H. and Herd, J. A.:Effects of propranolol, phentolamine and
methyl atropine on cardiovascular function
in the squirrel monkey during behavioral
experiments, 204
Kidneytubular transport of acetylcholine and atropine,
enhancement and inhibition, 14
tubular transport of choline, modificationscaused by intrarenal metabolism, 1
Kidwai, A. M., see Murthy, H. V., 166
Kimura, T., see Hashimoto, K., 388Kirpekar, S. M., see Puig, M., 130Kline, R. L. and Buckley, J. P. : In vitro myocar-
dial effects of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956), 399
Krell, H. D. and Patil, P. N. : Steric aspects of
adrenergic drugs. XIX. Influence of various
factors on the stereoselectivity of pre- and
postjunctional sites to norepinephrine isomersin isolated rat vasa deferentia, 101
Krell, R. D. and Patil, P. N. : Steric aspects of
adrenergic drugs. XX. Accumulation of (-)-
and (+)-norepinephrine-”C by peripheral
tissues of the rat, 273Krishnamurty, V. S. R. and Groliman, A. : Con-
tractile response of rat aorta to norepine-phrine and tyramine, 264
Kuntzman, H.,
see Jacobson, M. M., 312
see Kamm, J. J., 507
Levi, R. : Effects of exogenous and immunolog-ically released histamine on the isolated
heart: A quantitative comparison, 227
Levorphanol, failure to protect mice againstnaloxone-precipitated withdrawal, 189
Levy, B., see Wasserman, M. A., 256Lidocaine, effects on nicotine-induced changes
in perfused guinea-pig heart, 409Liver
lung and, rabbit, subcellular fractions, corn-
parison of distribution of enzymes between,
474
rat, drug metabolism, in vitro inhibition bymetabolites of progesterone, 320
rat, in vivo and in vitro N-dealkylation of N-t-
butylnorchlorcyclizine to norchiorcyclizinein, 507
rat, lysosomes, integrity in vivo, effects of steroi-
dal and nonsteroidal anti-inflammatorydrugs on, 179
rat , microsomal drug-metabolizing enzymes,5 ,5’-diphenyl-2-thiohydantoin as inducer of,
491rat, microsomal N-dernethylation of chlor-
cyclizine in vitro, sensitive assay for, 312
rat, pathway for daunornycin and adriamycinmetabolism in, 63
rat , rate of degradation of organic nitrates by,
56
slices, rabbit, glucose release by catecholamines,
antagonism by propranolol and phentolarnine,
370Lizard , melanophores , sulfhydryl requirement
for alpha adrenergic receptor activity and
melanophore stimulating hormone action on,
93Loh, H. H., see Ho, I. K., 155Long, II. J., see Soyka, L. F., 320
Lu, S. E., see Ho, I. K., 155
Lungliver and, rabbit, subcellular fractions, corn-
parison of distribution of enzymes between,
474microsomes, preparation, 474
Lysosornes, rat liver, effects of steroidal and
nonsteriodal ant i-inflammatory drugs on
integrity in vivo of, 179
Maling, H. M., see Zweig, M. H., 344
Mancomparison of effects of alcohol and marihuana
On temporally controlled operant in, 195dog and, mass spectrometric identification of
six new metabolites of propranolol in, 83
pharmacology of antimalarial drug 4,4’-di-formamidodiphenylsulfone in, 48
serum albumin, binding of catecholamines to,295
Mannitol hexanitrate, degradation by rat liver, 56Maren, T. H., see Sonntag, A. C., 34, 48Marihuana, alcohol and, comparison of effects on
temporally controlled operant in humans, 195Martin, J., see Freudenthal, R. I., 328Mass spectroscopy
high resolution, use in identification of metab-olites of daunomycin and adriamycin, 70
use in identification of six new metabolites ofpropranolol in man and dog, 83
Masters, T. N. and Glaviano, V. V. : The effects of
norepinephrine and propranolol on myocar-
dial subcellular distribution of triglycerides
and free fatty acids, 246Melanophore stimulating hormone and alpha
adrenergic receptor activity action on mela-
nophores, sulfhydryl requirement, 93
Meperidine, effect on reserpine metabolism invitro, 500
Mercurials, action on melanophores of lizard, 93
of
INDEX 539
Metabolism
clearance and, of organic nitrates, 56
drug, in vitro inhibition by metabolites of pro-gesterone, 320
intrarenal, modifications in renal tubular trans-port caused by, 1
microsomal, of 3H-reserpine, 500
of daunomycin and adriamycin via reductive
glycosidic cleavage, 63
of 4 , 4’ -diformamidodiphenylsulfone in man,
48of propranolol in man and dog studied by mass
spectrometry, 83Metabolites
new, of daunornycin and adriamycin, identifi-
cation, 70new, of propranolol in man and dog, mass spec-
trometric identification, 83Metanephrine, effects on nicotine-induced changes
in perfused guinea-pig heart, 409Methyl atropine, propranolol, phentolamine and,
effects on cardiovascular function in squirrel
monkey during behavioral experiments, 204
Methyldopa, hydralazine, guanethidine and,
antihypertensive agents , contribution of
central nervous system to action of, 135
Miceextracellular toxic reactions of some sulfur and
nitrogen mustards, 77
rnicrosomal metabolism of 3H-reserpine, 500morphine tolerant-dependent, influence of
p-chlorophenylalanine on morphine toleranceand physical dependence and regional brain
serotonin turnover studies in, 155pregnant, whole body distribution of nor-
ethindrone, ethynodiol diacetate and pro-
gesterone in, 328
protection against naloxone-precipitated with-
drawal, failure of opiate, 189
whole blood components, interactions with
protamine, 528
Microsomes
drug-metabolizing enzymes, 5,5’-diphenyl-2-
thiohydantoin as inducer of, 491
lung, preparation and comparison of distri-
bution of enzymes between subcellular frac-
tions of rabbit lung and liver, 474
mice, metabolism of 3H-reserpine, 500
Misher, A., see Groppetti, A., 464
Molinoff, P. B., Brimijoin, S., and Axelrod, J.:
Induction of dopamine-�9-hydroxylase and
tyrosine hydroxylase in rat hearts and sym-
pathetic ganglia, 116
Monkey
dog and, pharmacology of antimalarial drug
4, 4’-diformamidodiphenylsulfone in, 34
squirrel, cardiovascular function during be-
havioral experiments, effects of propranolol,
phentolamine and methyl atropine, 204
Monoamine, stores in rat brain, effects of SK&F1-39728, fenfluramine and d-amphetamine,
464
Monoamine oxidase
inhibition, effect on accumulation of norepi-nephrine isomers in rat vasa deferentia, 101
inhibition, effects on dopamine levels in rat
striatum, 454
inhibitors, effect on activity of dopamine-�-
hydroxylase and tyrosine hydroxylase in rathearts and ganglia, 116
Morphine
effects on nicotine-induced changes in perfused
guinea-pig heart, 409
tolerance and physical dependence and regionalbrain serotonin turnover in tolerant-de-
pendent mice, influence of p-chlorophenylal-
anine, 155Morse, W. H., see Kelleher, R. T., 204
M#{252}hlbachov#{225}, E., Chan, P. S. and Ellis, S. : Quan-
titative studies of glucose release from rabbit
liver slices induced by catecholamines andtheir antagonism by propranolol and phen-
tolamine, 370
Munson, P. L., see Peng, T.-C., 522
Murthy, R. V., Kidwai, A. M. and Daniel, E. E.:
The uptake of cardiac glycosides by rabbit
and rat myometrium, 166
Muscarinic receptors, nicotinic and, comparison
of action of acetylcholine and acetylcholine
mustard on, 303
Muscle
papillary , blood-perfused, canine , automa-
ticity in, effects of therapeutic and toxic
doses of ouabain, 388
sartorius, frog, end-plate membranes, mecha-
nisms of dual action of nicotine, 427
smooth, contraction, ouabain antagonism of,
378
Mustards, sulfur and nitrogen, extracellular
toxic reactions, 77
Myocardium, subcellular distribution of triglyc-
erides and free fatty acids, effects of norepi-
nephrine and propranolol, 246Myometrium, rabbit and rat, uptake of cardiac
glycosides by, 166
Naimzada, M., see Groppetti, A., 464
Naloxone-precipitated withdrawal, failure
opiate to protect mice against, 189
Narahashi, T., see Wang, C. M., 427, 442
Needleman, P., see Johnson, E. M., Jr., 56
Nerveblocking action of allethrin, mechanism of
negative temperature coefficient, 442
�540 INDEX
terminals, sympathetic, in blood vessel, uptakeof nicotine, 419
Nervous system
. central , contribution to action of antihyper-tensive agents (methyldopa, hydralazine and
guanethidine), 135central, neurons, release of norpinephrine from,
284sympathetic, effect of chronic treatment with
pargyline and l-dopa on, 130Neurons
adrenergic, in perfused guinea-pig heart, media-
nism of action of nicotine in, 409central nervous system, release of norepi-
nephrine from, 284Nicotine
mechanism of action in adrenergic neurons �I1
perfused guinea-pig heart , 409mechanisms of dual actions On end-plate mem-
branes, 427uptake by sympathetic nerve terminals in
blood vessel, 419Nicotinic receptors, muscarinic and, comparison
of action of acetyicholine and acetylcholine
mustard on, 303
Nitrates, organic, clearance and metabolism, 56p-Nitroanisole, effect on hepatic drug metabolism,
320
Nitrogen and sulfur mustards, extracellular toxic
reactions, 77Norchiorcyclizine, N-dealkylation by rat of N-t-
butylnorchlorcyclizine to, 507Norepinephrine
amphetamine-induced release from rat cerebral
cortex in vitro, characteristics, 284. binding to human serum albumin, 295
brain, effect of 2,5-dimethoxy-4-methylam-phetamine on, 145
concentrations in rat brain, effects of SK&F1-39728, fenfluramine and d-amphetamine,464
content of cat spleen and coeliac ganglia, effectof chronic treatment with pargyline andl-dopa, 130
-induced glucose release from rabbit liver slices,antagonism by propranolol and phentolamine,
370
isomers, in isolated rat vasa deferentia, in-fluence of various factors on stereoselectivity
of pre- and postjunctioaal sites to, 101neuronal uptake , relationship with nicotine-
. induced release of norepinephrine, 409propranolol and, effects on myocardial sub-
cellular distribution of triglycerides and freefatty acids, 246
tyramine and, contractile response of rat aorta. to,264
Norepinephriae-’�C, (-)- and (+)-, accumulation
by peripheral tissues of rat, 273Norethindrone , ethynodiol diacetate , progester-
one and, whole body distribution in pregnant
mouse, 328
Oral contraceptive, effect on spontaneous running
activity, salt appetite and blood pressure of
ovariectomized rats, 335Organic nitrates, clearance and metabolism, 56Ouabain
antagonism of smooth muscle contraction, 378therapeutic and toxic doses, effects on automa-
ticity ill blood-perfused canine papillary
muscle preparation, 388uptake by rabbit and rat myometrium, 166
Papillary muscle, blood-perfused, canine, auto-
maticity in, effects of therapeutic and toxic
doses of ouabain, 388Pargyline
-induced changes in dopainine levels iii rat
striatum, 454l-dopa and, chronic treatment, effect on sym-
pathetic nervous system, 130Paroxon, effect on acetylcholine transport efli-
ciency in kidney, 14Patil, P. N., see Krell, it. 1)., 101, 273
Peng, T.-C., Cooper, C. W. and Munson, P. L.:The hypocalcemic effect of urethane in rats,
522Pentaerythritol trinitrate, degradation by rat
liver, 56Pentolinium, effects on nicotine uptake in rabbit
aortic strip, 419Phenobarbital, as inducer of drug-metabolizing
enzymes , comparison with 5 , 5’-diphenyl-2-thiohydantoin, 491
Phenoxybeazamineaction on melanophores of lizard, 93
effects on nicotine-induced changes in perfused
guinea-pig heart, 409
effects on nicotine uptake in rabbit aortic strip,419
Phentolamineblockade of effects of norel)inephrine and tyra-
mine on rat aorta, 264
propranolol and, antagonism of glucose release
from rabbit liver slices induced by catechol-
amines, 370
propranolol, methyl atropine and, effects on
cardiovascular function in squirrel monkey
during behavioral experiments, 204
Physical dependence, on morphine in mice, tol-
erance and, influence of p-chlorophenylal-
anine on, 155
INDEX 541
Physostigmine , effect on acetylcholine transport
efficiency in kidney, 14Piperocaine , effects on nicotine-induced changes
in perfused guinea-pig heart, 409
Poland, A., see Jacobson, M. M., 312Practolol, effect on responses to isoproterenol of
rat uterus, atria and fundus, 256
Pregnanedione, effect on hepatic drug metabolism,320
Pregnanolone, effect on hepatic drug metabolism,320
Progesterone
metabolites, in vitro inhibition of drug metabo-lism by, 320
norethindrone, ethynodiol diacetate and, wholebody distribution in pregnant mouse, 328
Propranololeffect on responses to isoproterenol of rat
uterus, atria and fundus, 256
effect on Ro 7-2956-induced changes in guinea-pig atria, 399
effects on ouabain-iaduced changes in auto-
maticity of blood-perfused canine papillarymuscle, 388
metabolism in man and dog, mass spectrometricidentification of six new metabolites, 83
norepinephrine and, effects on myocardialsubcellular distribution of triglycerides and
free fatty acids, 246phentolamine and, antagonism of glucose re-
lease from rabbit liver slices induced by
catecholamines, 370
phentolamine, methyl atropine and, effects oncardiovascular function in squirrel monkey
during behavioral experiments, 204Protamine, interactions with mouse whole blood
components, 528Puig, M., Wakade, A. R. and Kirpekar, S. M.:
Effect on the sympathetic nervous system ofchronic treatment with pargyline and l-dopa,
130Putney, J. W., Jr. and Borzelleca, J. F. : Mecha-
nisms of “C-salicylic acid excretion by the
rat submaxillary gland, 515
Quinidine, aminoguanidine and, effect on hista-Inine levels in rat and rabbit blood vessels,
239
Rabbit(s)aortic strips, comparison of actions of acetyl-
choline and acetylcholine mustard on, 303aortic strips, uptake of nicotine, 419blood vessels, disposition of histamine in, 239liver slices, glucose release by catecholamines,
antagonism by propranolol and phentola-mine, 370
lung and liver, subcellular fractions, comparison
of distribution of enzymes between, 474myometrium, rat and, uptake of cardiac gly-
cosides by, 166
sheep, dogs, rats, guinea pigs and, effect ofethacrynic acid on bile formation in, 27
Rat(s)
aorta, contractile responses to norepinephrineand tyramine, 264
blood vessels, disposition of histamine in, 239cerebral cortex, characteristics of in vitro am-
phetamine-induced release from, 284clearance and metabolism of organic nitrates
in, 56contribution of central nervous system to action
of antihypertensive agents (methyldopa,hydralazine and guanethidine) in, 135
daunomycin and adriamycin metabolism eia
reductive glycosidic cleavage in, 63
5 ,5’-diphenyl-2-thiohydantoin as inducer ofmicrosomal drug-metabolizing enzymes in,
491evidence that 1-benzyl-�3-methoxy-3-triflu-
oromethylphenethylamine (SK&F 1-39728)
dissociates anorexia from central stimulationand actions on brain monoamine stores, 464
hearts, sympathetic ganglia and, induction ofdopamine-�9-hydroxylase and tyrosine hy-
droxylase in, 116
hindpaw edema, sodium urate-induced, in-hibition by colchicine derivatives correlated
with antimitotic activity, 344in vitro inhibition of drug metabolism by metab-
olites of progesterone in, 320
in vivo and in vitro N-dealkylation of N-t-butyl-norchlorcyclizine to norchlorcyclizine by,
507hypocalcemic effect of urethane in, 522
jejunum, comparison of action of acetylcholine
and acetylcholine mustard on, 303
liver lysosomes, integrity in vivo, effects of
steroidal and nonsteroidal ant i-inflammatory
drugs on, 179
myometrium, rabbit and, uptake of cardiac
glycosides by, 166ovariectomized, effect of oral contraceptive on
spontaneous running activity, salt appetite
and blood pressure of, 335
peripheral tissues, accumulation of (-)- and
(+)-norepinephrine-’�C by, 273selective beta adrenergic receptor blockade in,
256
sensitive assay for hepatic N-demethylation ofchlorcyclizine in vitro in, 312
sheep, dogs, guinea pigs, rabbits and, effect of
ethacrynic acid on bile formation in, 27
542 INDEX
striatum, dopaminergic terminals, feedbackcontrol of dopamine synthesis in, 454
submaxillary gland, mechanisms of ‘4C-salicylic
acid excretion by, 515tissues, assay for tryptamine in, 363
vasa deferentia, isolated, influence of variousfactors on stereoselectivity of pre- andpostjunctional sites to norepinephrine in,
101
Renal tubule
transport of acetylcholine and atropine, en-hancement and inhibition, 14
transport of choline, modifications caused byintrarenal metabolism, 1
Rennick, B., see Acara, M., 1, 14
Reserpine
effect on accumulation of norepinephrine iso-
mers in rat vasa deferentia, 101
effect OII activity of dopamine-�-hydroxylase
and tyrosine hydroxylase in rat hearts andganglia, 116
effect On histamine levels in rat and rabbit
blood vessels, 239pretreatment, influence on effects of norepi-
nephrine and tyramine on rat aorta, 2643H-Reserpine, microsomal metabolism, 500
Revuelta, A., see Groppetti, A., 464
Ro 7-2956 [4-(3,4-dimethoxybenzyl)-2-imidaz-
olidionel, in vitro myocardial effects, 399Ross, S. B. and Akerman, S. B. A. : Cyclization of
three N -w - haloalkyl -N-methylaminoaceto-
2,6-xylidide derivatives in relation to their
local anesthetic effect in vitro and in vivo, 351
Rutledge, C. 0., see Ziance, H. J., 284
Saavedra, J. M. and Axelrod, J. : A specific andsensitive enzymatic assay for tryptamine intissues, 363
‘4C-Salicylic acid, mechanisms of excretion by ratsubmaxillary gland, 515
Salt appetite , spontaneous running activity,blood pressure and, in ovariectomized rats,
effect of oral contraceptive, 335
Sapira, J. D., see Dalton, A., 295Sartorius muscle, end-plate membranes, frog,
mechanisms of dual action of nicotine, 427Schwartzbach, E., see Asbell, M. A., 63Sciatic nerves, guinea pig and frog, cyclization of
three N - w - haloalkyl - N - methylaminoaceto -
2,6-xylidine derivatives in relation to their
local anesthetic effect in, 351
Scuka, M., see Wang, C. M., 442
Seligman, A. M., see Williamson, C. E., 77
Serotoninbrain, effect of 2,5-dimethoxy-4-methylam-
phetamine on, 145brain, turnover, in morphine tolerant-dependent
mice, influence of p-chlorophenylalanine, 155
concentrations in rot brain, effects of SK&F
1 -39728, fenfluramine and d-amphetami tie,464
-induced smooth muscle contraction, effect of
ouabain, 378Serum albumin, human, binding of catechola-
mines to, 295Shaw, H., Caple, I. and Heath, T. : Effect of
ethacrynic acid on bile formation in sheep,dogs, rats, guinea pigs and rabbits, 27
Sheep, dogs, rats, guinea pigs, rabbits and, effect
of ethacrynic acid on bile formation in, 27Shropshire, A. T., see Baum, T., 135SK&F 1-39728 (1-benzyl-fl-methoxy-3-trifluo-
romethylphenethylamine) , dissociation of
anorexia from central stimulation and actions
OIl brain monoamines stores in rat by , 464
SKF 525A, effect on reserpine metabolism in vitro,
500
Smooth muscle, contraction, ouabaia antagonismof, 378
Sodium thiosulfate, use to prevent toxic effects of
sulfur and nitrogen mustards, 77Sodium orate-induced rat hindpaw edema, in-
hibition by colchicine derivatives correlatedwith antimitotic activity, 344
Sonatag, A. C., Stenger, V. (. and Maren, T. II.:The pharmacology of the antimalarial drug
4, 4’-diformamidodiphenylsulfone in man, 48Sonntag, A. C. , Stenger, V. U. , Vogh, B. P. and
Marezi, T. H. : The pharmacology of the an-
timalarial drug 4 , 4’-diformamidodiphenyl-sulfone (DFD) in dog and monkey, 34
Soyka, L. F. and Long, R. J. : In vitro inhibitionOf drug metabolism by metabolites of pro-
gesterone, 320
Spector, S., see Howland, H. D. , 239Squid, giant axons, mechanism of negative tem-
perature coefficient of nerve blocking action
of allethrin in, 442St-155, see ClonidineStaadaert, F. (l., see Gillis, H. A., 218
Stawarz, 11. J., see Stitzel, H. E., 500
Stenger, V. G., see Sonntag, A. C. , 34, 48
Stitzel, H. E., Wagner, L. A. and Stawars, II. J.:
Studies on the microsomal metabolism of
‘H-reserpine, 500
Stolman, S., see Ho, I. K., 155Striatum, rat, dopaminergic terminals, feedback
control of dopamine synthesis in, 454Stubbins, J. F., see Hudgins, P. M., 303Su, C., see Bevan, J. A., 419
Subcellular fractions, of rabbit lung and liver,
comparison of distribution of enzymes, 474
Submaxillary gland, rat, mechanisms of 14csalicylic acid excretion by, 515
Sulfhydryl requirement, for alpha adrenergicreceptor activity and melanophore stimu-
INDEX 543
lating hormone action on melanophores, 93Sulfur and nitrogen mustards, extracellular toxic
reactions, 77
Sympathetic ganglia, hearts and, rat, induction of
dopamine-$-hydroxylase and tyrosine hy-droxylase in, 116
Sympathetic nerve, terminals, in blood vessel,
uptake of nicotine, 419
Sympathetic nervous system, effect of chronic
treatment with pargyline and l-dopa on, 130Szaro, H. P., see Griffin, J. D., 378Szuna, A., see Kamm, J. J., 507
Temperature coefficient , itegat ive , of nerveblocking action of allethrin, mechanism, 442
Tetrodotoxin , effects on nicotine-induced changes
in perfused guinea-pig heart, 409Tissues
peripheral, rat, accumulation of (-)- and (+)-
norepinephrine-14C by, 273specific and sensitive assay for tryptamine in,
363
Toxic reactions, extracellular, of some sulfur and
nitrogen mustards, 77Triglycerides, free fatty acids and, myocardial
subcellular distribution, effects of norepi-
nephrine and propranolol, 246Tropolone , pretreatment , effect on accumulation
of (-)- and (+)-norepinephrine-’4C by rat
peripheral tissues, 273Tryptamine, in tissues, specific and sensitive
assay for, 363Tsai, I., see Jacobson, M. M., 312
d-Tubocurarineeffects on nicotine-induced changes in end-
plate membranes, 427
effects on nicotine uptake in rabbit aortic strip,
419Tyramine, norepinephrine and, contractile re-
spouse of rat aorta to, 264Tyrosine hydroxylase, dopamine-�9-hydroxylase
and, induction ill rat hearts and sympathetic
ganglia, 116
Urethane, hypocalcemic effect in rats, 522Uterus, rat, responses to isoproterenol, effects of
propranolol, practolol and butoxamine, 256
Varner, L. L., see Baum, T., 135Vas deferens, rat, isolated, influence of various
factors on stereoselectivity of pre- and
postjunctional sites to norepinephrine in, 101
Vogh, B. P., see Sonatag, A. C., 34
Wagner, L. A., see Stitzel, B. E., 500
Wakade, A. IL, see Puig, M., 130
Wall, M. E., see Freudenthal, H. I., 328
Wallach, M. B., Friedman, E. and Gershon,S. : 2,5 - Dimethoxy-4 -methylamphetamine
(DOM) , a neuropharmacological examination,
145Walle, T. and Gaffney, T. E. : Propranolol metab-
olism in man and dog: Mass spectrometricidentification of six new metabolites, 83
Wang, C. M. and Narahashi, T. : Mechanisms of
dual action of nicotine on end-plate mem-
branes, 427
Wang, C. M., Narahashi, T. and Scuka, M. : Mech-
anism of negative temperature coefficient
of nerve blocking action of allethrin, 442
Wasserman, M. A. and Levy, B. : Selective beta
adrenergic receptor blockade in rat , 256Way, E. L., see Ho, I. K., 155
Webster, C. D., see Cappell, H., 195
Webster, M. E., see Zweig, M. H., 344Weltman, J. K., see Griffin, J. D., 378
Westfall, T. C. and Brasted, M. : The mechanismof action of nicotine in adrenergic neurons in
the perfused guinea-pig heart , 409Williamson, C. E., Seligman, A. M. and Witten,
B. : Extracellular toxic reactions of somesulfur and nitrogen mustards, 77
Witten, B., see Williamson, C. E., 77
Yesair, D. W., see Asbell, M. A., 63
Ziance, H. J., Azzaro, A. J. and Rutledge, C. 0.:
Characteristics of amphetamine-induced re-
lease of norepinephrine from rat cerebralcortex in vitro, 284
Zweig, M. H., Maling, H. M. and Webster, M. E.:Inhibition of sodium urate-induced rat
hindpaw edema by colchicine derivatives:Correlation with antimitotic activity, 344