Index to Volume 19

Abnormal haemoglobins, sepa ration a nd charact eriza t ion of the a- and ,'l-chains by chromato-graph y , and t he determination of two new variants Hb Ches ape ake and HbJ (Bangkok), 91

F -Actin , tbe removal of bound aden osine d iph osphate, 483Ad en osin e di phosphate bound to F vactin , its rem oval, 483Antiviral action of 5-iodouracil deox yriboside, 320

BACllRACH, G. & LEIBOVICI, J. , Inhibitory effect of oxidized sp ermine on the multiplication ofcoliphage T5, 120

Bacteriophage f2 mutants. VIII. Control mechanisms for phage.specific syntheses, 333-·induced DNA methylase, 219- .\, action of the chromosome controlling functions late in bacteri ophage development, 187- .\ D)l'A, on the probability of ring closure, 469- 9'80, inversion of the lac op eron in transduction of lac to Escherichia coli, 254-T-ev en, early messenger in vitro, select ive synthesis, 541BAXK, A. (see COXCONI, F. M .) , 525BARANY, )L, TuCCI, A. F. & CONOVER, T. E ., The removal of the bo und aden osine diphosphate of

F-actin, 483BECKWITH, J. R. & SroNER, E. R., Transp osition of the lac region of Escherichia coli . I. Inversion of

t he lac op eron and transduction of lac by 9'80, 254- (see Fox, C. F.), 576BEN-PORAT, T. (see KAPLAN, A. S. l, 320BERGQ'GIST, P. L. & CAPECCHI, M . R ., Fractionation of a suppressor sRKA, 202BEYCHOK, S. (see FAS:Il:AN, G. D.), 240BIRNBonr, H. C., (see SOEIRO, R .), 362- (see W ARNER, J. R ), 349BLAKE, R D. & FRESCO, J. R. , Polynucleotides. VII. Spectrophotometric study of the kinetics of

format ion of the two-stranded hel ical complex resulting from the interac tion of'polyrlboaden y­late and polyribouridylste, 145

BOCK, R . )1. (see SULL, D.), 556BOREK, E. (see SELLIN, H . G.) , 219B OYCE, R. P . (see CLARK, A. J .), 442BOYER, P . D. (see RICHARDS, O. C.) , 109BRENNER, S., KAPLAN, S. & STRETTON, A. O. W., Identity of N 2 and ochre nonsense mutants, 574BREILLATT, J. & DICKMAN, S. n., Effect of magnesium chloride and potassium chloride on the

sedimentation characteristics of r ibonucleoprotein isolated from dog pancreas, 227BROWN. D. D. & GL"RDON, J. B. , Size distribution and stability of DNA-like RNA synthesized

during development of anuclcolate embryos of Xenopus laevis, 399BROWS, D. M. (see ZOMZELY, C. E .), 455

CAPECCHI, M. R. (see BERGQ'GIST, P. L.), 202,'l·Casein in solution, transconformation; analysis of a thermal transit ion between 5 and 40°C, 586Carboxypeptidase A, st ructure , III. Molecular structure at 6 A resol uti on, 423Cerebral protein synthesis. I. Physical properties of cerebral ribosom es and polyribosomcs, 455CHAMBERLIN,1\£. (see CLARK, A . J .), 442ClIERAYIL, J . D. (see SOLL, D.), 556CHERRY, J . H . (see CHROBOCZEX, H .), 28CHROBOCZEK, H. & CHERnY, J . H .• Charac te r izat ion of nucleic acids in peanut coty ledons. 28Chromosome of lambda, action in cont roll ing function s late in bac teriophage development, 18iChymotrypsin, the conformational transition from chymotrypsinogen, 240Chymotrypsinogen: chymotrypsin , conform at ional transition, 240CLARK, A. J .• CHA:\IBERLIN, M., B OYCE, H. P . & HOWARD-FLANDl-:RS, P., Abnormal m etabolic

response to ultraviole t light of a recombinat.ion-doficient mutant of Esc herichia coli K12, 442

vii

viii INDEX

CLEGG, J . B., NAUGHTON, )1. A. & WE ATHERALL, D. J ., Abnormal human haemoglobins: separa­ti on an d characterizat ion of the ex- and ,a-chains by chromatog raphy, and the determinationof two n ew variants, H b Chesapeake and Hb J (Bangkok) , 91

Codon-anticodon pairing: the wobble hypothesis , 548Codon, AU G for formylmethionine , its role in phasing transla ti on of synthetic messenger RNA, 74- recognition as st udied by ribosomal binding t echn ique , specificity of sR NA, 556Coliph age, inhibitory effect of oxidized spermine on multi pl ication, 120CoLVILL, A. J. E. (see GEIDUSCHEK, E . P.) , 541Com pl em entation, interallelic, induced by supe r -su ppression , 583CONCO~I, F.l\I. , BANK, A. & MARKS, P . A ., P olyribosomes and cont rol of prot ein synthesis: effect s

of sod ium fluoride and tempe rature in reti culo cytes, 525CONOVER, T. E. (see BARANY, M.) , 483Control m echanism s for phage-specific synthesis in mutants of f2, 333COPPOLA, J. C. (see LIPSCOMB, \V. N .), 423Cotton seeds, germinating, RNA synthesis, 1CRICK, F. H. C., Codon-anticodon p airing: the wobble hypot hesis, 54 8

DARNELL, J. E. (see SOEIRO, R.) , 362- (see WARNER, J. R), 349, 375DAVIDSON, N. (see WANG, J. C.), 469Deoxyribonucleic acid in solution, t erminology of configurational ch anges, 287- -, inter-strand crosslinking by nitrogen mustard, 266- --like RNA synthesized during development of anucleolate em bryos of Xenopus laevis, size

d istribution and stability, 399- - m ethylase induced by a bacteriophage , 219- -, ni trogen mustard-crosslinked, t ransforming activ it y, 289- - , ' ·O-labeling during synthesis and stability of the label during replica tion, 109- - of bacteriophage .\, on the probability of ring closure, 469- - replication and messenger RNA production, 174D eoxyribo side, 5.iodourac il, mod e of antivir al action, 320DEROSIER, D. J. & HASELKORN, R. , Particle weigh t of t urnip ye llow mosai c v ir us , 52DICKMAN, S. R (see BREILLATT, J .), 227Dielectric di sp ersion of bo vine serum album in , 133Dimers and h ydrates, excision from ultraviolet-irradiated poly U b y pancrea t ic ribonuclease, 303DOTY, P. (see KOHN, K. W.), 266DOVE, W . F., Action of the lambda chrom osome. I. Control of functions late in bacteriophage

dev elopment, 187DURE, L. S., lIT. (see WATERS, L . C.) , 1

ECHOLS, H . (see HILL, C. W .), 38- (see JOYNER, A.) , 174EpSTEIN, W . (see Fox, C. F.), 576Esch erichia coli and yeast tyrosine transfer RNA, species sp ecificity, 161- - K12, abnormal m etabolic response to ultraviolet light of a recombination-deficient mutant,

442- -, properties of a mutant blocked in inducibility of mRNA for the galactose operon, 38- -, protein synthesis in a relaxed-control mutant upon recovery from m ethionine starvation, 60- - ribosome subunit, use in det ermination of streptomycin sensitivity , 207- - 30 S ribosomes, the structural components and streptomycin sensitivity, 211- - , transposition of the lac r egion. I. Inversion of the lac op eron and transduction of lac by 9'80,

254- - - - - - - II. On the role of thiogalactoside transacetylase in lacto se metabolism, 576

f2 (see b acteriophage), 333FASMAN, G. D. , FOSTER, R. J . & BEYCHOK, S., The conformational transition associated with the

act ivation of chymotrypsinogen t o chymotrypsin, 240FAULKNER, R D. (see SOLL, D. ), 556F ibroin, silk , a model for the crystall ine regions: POlY·L-alanylglycyl-L-alanylglycyl.L.serylglycine,

580F ormylmethionine codon AU G, its role in phasing transla t ion of syntheti c messenger RNA, 74FOSTER, R. J. (see FAS?1AN, G. D .), 240Fox, C. F., BE CKWITH, J. R., EpSTEIN, W. & SIGNER, E. R ., Transposition of the lac region of

E scherichia coli. II. On the role of t h iogal act oside t ransacetylase in lacto se m etabolism, 576

INDEX IX

FRASER, R . D . B. , MACR AE, T. P . & STEWART. F. H. C., PoIY-L-alanylglycyl-L-alanylglyc yl_L_serylglycine : a model for the crystall ine regions of silk fibroin , 580

FRESCO, J . R . (see J~LAXE, R . D .), 145

Galactose messenger R~A, a mutant blocked in inducibility, 38GARNIER, J ., Conformation de la easeine p en solution analyse d'une transition thermique ent re

5 et 40°C, 586Gzrrrc scmsx, E. P., S~YDER, L ., COLVILL, A. J. E . & SARNAT, M., Selective synthes is of T veven

bacteriophage ea rly messen ger in vitro, 541GIRARD, M .(see 'VAR~R, J. R .), 349, 373GRANT, E. H., Dielectric disp ersion in bovine serum albumin, 133GREEN, D. M. (see K OHN, K. W. ), 289GURDON, J . B. (see BROWN, D. D .), 399

Haemoglobins, abnormal human; separation and charac t erization of the 0;- and p-chains bychromatography, and the determination of two new variants, Hb Chesapeake and Hb J(Bangkok), 91

HAMPEL, A. (see SOLL, D.) , 556HARTSUCX, J. A. (sel) LIFSCOMB, w. ~.), 423HASELKORN, R . (see DEROSIER, D. J . ), 52HAYASIU, H ., Species specificity of tyros ine t ra nsfer RNA 's from E scherichia coli and yeas t, 161HAYATSlJ, H. (see SOLL, D .), 55 6HeLa cell nuclear rap idl y labelled RNA.!. Identi fication by zone sedimentation of a heterogenous

fraction separate from ri b osomal pre cursor R~A, 349- -,- - - - - II. Base compo sit ion and cellul ar localization of a h eterogeneous RNA fraction,

362- cells , r ibosome formatlon in the absen ce of protein synthesis , 373- -, the assembly of r ibosomes, 383Helical complex resulting from the interaction of polyriboadenylate and polyribouridylate,

145HILL, C. tV. & ECHOLS, H. , Properties of a mutant blocked in inducibility ofmRNA for the galac-

tose op eron of Escherichia coli, 38HILLS, G. J. (see SIEGEL, A.), 140Histon es, ra t liv er, to which hydrocortisone is bound, 591HOSOKAWA, K. (see TRAUB, P .), 211HOWARD-FL~DERS, P. (see CLARK, A. J.), 442H ydrat es and dimer s, excision from ultraviolet-irradiat ed po ly U by pancrea tic ribonuclease,

303Hydrocor ti sone bound to rat liver histones, 591

INGE-YE CHTOMOV, S. G., Sor IlLA, T. R., Ko:hN, S. A. & SIMAROV,B. Y., Super-suppressor in ducedintorallelic complementation, 583

5-Iodouracil deoxyriboside, mode of antiviral action, 320ISAACS, L. N. (see JOYNER, A.), 174

JOHNS, H. E. (see P.~ARSON, M.), 303JONE S, D. S. (see Sou ., D.), 556JOYNER, A. , I SAACS, J•. N., E CHOI,S, H . & SLY, "\-\T.S. , DNA replication and messenger RNA produc­

tion , 174

KAPLAN, A. S. & BEN,PORAT, T., Mode of antiviral action of 5-iodouracil deoxyriboside, 320KAPLAN, S. (sec BRENNER, S.), 574KHORA..."iA. H. G. (see SOLL, D.), 556KOHN, K . W. & GREEN, D. M., Transforming activity of nitrogen musturd-crosslinked DNA.

289

x I~DEX

KOHN, K. W., SPEARS, C. L. & DOTY, P., Inter-strand crosslinking of D~A by nitrogen mustard,266

Appendix: Terminology of configurational changes of D~A in solution, 287KOZIN, S. A. (see boGE-VECHTOMOV, S. G.), 583

Lac region of Escherichia coli, transposed, I. Inversion of the lac operon and transduction of lacby '1'80. 254

- - - - - - II. On the role of thiogalactoside transacetylase in lactose metabolism, 576A(see bacteriophage), 187,469LATHAM, H. (see WARNER, J. R.), 373LEBERMAN, R. (see LmwLEY, W.), 223LEIBOVICI, J. (see BACHRACH, "G.), 120LIPSCOMB, W. N., COPPOLA, J. C., HARTSUCK, J. A., LUDWIG, M. 1.., MUIRH~~AI>, H., SEARL, J. &

STEITZ., T.A., The structure of carboxypeptidase A. III. Molecular structure at 6 A resolution,423

LODISH,H. F. & ZINDER, N. D., Mutants of bacteriophage f2. VIII. Control mechanisms for phage­specific syntheses, 333

LOliRMANX, R. (SOI.L, D.), 556LONGLEY, W. & LEBERMAN, R., Structural similarity of artificial and natural top components 'of

turnip yellow mosaic virus, 223LUDWIG, M. L. (see LIPSCOMB, W. X.), 423

MACRAE, T. P. (see FRASER, R. D. B.), 580Magnesium chloride and potassium chloride, their effect on the sedimentation characteristics of

ribonucleoprotein isolated from dog pancreas. 227MARKHAM, H. (see SIEGEL, A.), 140MARKS, P. A. (see CONCONI, F. M. ), 525MESELSON, M. (see STAEIJELIN, T.), 207Messenger RNA for the galactose operon of Escherichia coli, properties of a mutant blocked in

inducibility, 38-- production and DNA replication, 174--, synthetic, the role of the formylmethionine codon AUG in phasing translation, 74Methionine starvation, its effect on protein synthesis in a relaxed-control mutant of Escherichia

coli, 60Methylase, DXA, bacteriophage-induced, 219MUIRHEAD, H. (see LIPSCOMB, W. N.), 423Mutant blocked in inducibility of mRNA for the galactose operon of Escherichia coli, 38- of Escherichia coli K12, recombination deficient, abnormal metabolic response to ultraviolet

light, 442Mutants of bacteriophage f2. VIII. Control mechanisms for phage-specific synthesis, 333-, N2 and ochre nonsense, identity, 574MUTO, A., OTAKA, E. & OSAWA, S., Protein synthesis in a relaxed-control mutant of Escherichia

coli upon recovery from methionine starvation, 60

X2 and ochre nonsense mutants, identity, 574NAUGHTON, M. A. (see CI"~~GO, J. B. ),91Xitrogen mustard causing inter-strand crosslinking of D~A, 266-- crosslinked DKA transforming activity, 289KOMURA, M. (see TRAUB, P.), 211, 215Nonsense mutants, ochre and K2, identity, 574Nuclear RNA rapidly labelled, from HeLa cells, I. Identiflcetion by zone sedimentation of a hetero­

genous fraction separate from ribosomal precursor RNA, 349--, II. Base composition and cellular localization of a heterogenous RNA fraction, 362Nucleic acids in peanut cotyledons, 28

ISO-labeling of DNA during synthesis and stability of the label during replication, 109Ochre and N2 nonsense mutants, identity, 574OHTSUKA, E. (see StiLL, D.), 556OSAWA, S. (see MUTo, A.), 60OTAKA, E. (Bee MUTO, A.), 60

INDEX xi

PALADE, G. E. (see SABATINI, D. D.), 503Peanut cotyledons, the nucleic acids, 28PEARSO~, M. & JOHNS, H. E., Excision of dimers and hydrates from ultraviolet-irradiated poly U

by pancreatic ribonuclease, 303'1'80 (see bacteriophage), 254PM2 tobacco mosaic virus protein. in vitro and in vivo aggregation, 140Poly.L-alanylglycyl-L-alanylglycyl-L-serylglycine: a model for the crystalline regions of silk

fibroin, 580Polynucleotides. VII. Spectrophotometric study of the kinetics of formation of the two-stranded

helical complex resulting from the interaction of polyriboadenylate and polyribouridylate, 145Polyriboadenylate and polyribouridylatc, spectrophotometric study of the kinetics of interaction,

145Polyribosomes and control of protein synthesis: effects of sodium fluoride and temperature in

reticulocytes, 525- and cereb~al ribosomes, physical properties, 455Polyribouridylate and polyriboadenylate, spectrophotometric study ofthe kinetics ofinteraction, 145Polyuridylic acid, ultraviolet-irradiated, excision of dimers and hydrates by pancreatic ribonuc-

lease, 303Potassium chloride and magnesium chloride, their effect on the sedimentation characteristics of,

ribonucleoprotein isolated from dog pancreas, 227Protein synthesis, cerebral. I. Physical properties of cerebral ribosomes and polyribosomes, 455- - control, and polyribosornes, 525PROVOST, C. (see ZO:lfZELY, C. E.), 45;;

Replication of DXA and messenger RKA production, 174Reticulocytes, effects of sodium fluoride and temperature, 525Ribonuclease, pancreatic, its excision of dimers and hydrates from ultraviolet-irradiated poly D,

303Ribonucleic acid, DXA-like, synthesized during development of anucleolate embryos of Xenopus

laeuis, size distribution and stability, 399- - messenger, for the galactose operon of Escherichia. coli, properties of a mutant blocked in

inducibility, 38- -, -, production and DXA replication, 174- -, rapidly labeled, nuclear, from HeLa cells. 1. Idontiflcation by zone sedimentation of a

heterogeneous fraction separate from ribosomal precursor RNA, 349- -, - -, - - - - .Il. Base composition and cellular localization of a heterogeneous RKA

fraction, 362- - synthesis in germinating cotton seeds, I- -, synthetic messenger, the role of the formylmethionine codon AUG in phasing translation, 74sRibonucleic acid, specificity for recognition of codons as studied by ribosomal binding technique,

556- -, suppressor, fractionation, 202Ribonucleoprotein isolated from dog pancreas, effect of magnesium chloride and potassium

chloride on the sedimentation characteristics, 227Ribosomal binding technique used to study specificity of sRXA for recognition of eodons, 556- precursor RKA, identification by zone sedimentation of a separate heterogeneous fraction using

rapidly-labelled HeLa cell nuclear RXA, 349- proteins, physical and functional heterogeneity, 215Ribosome assembly in HeLa cells, 383- formation in HeLa cells in the absence of protein synthesis, 373Ribosomes, cerebral, and polyribosomes, physical properties, 455- of Escherichia coli, determination of streptomycin sensitivity by a subunit of 30 8 type, 201- - -, the structural components and streptomycin sensitivity of 30 8 type, 211-, their attachment to microsomal membranes, 503RICHARDS, O. C. & BOYER, P. D., lBO-labeling of DXA during synthesis and stability of the labol

during replication, 109Ring closure of'\ DNA, 469ROBEHTS, S. (see ZO:lfZELY, C. Eo), 455

SABATI~I, D. D., TASHIRO, Y. & PALADE G. E., On the attachment of ribosomes to microsomalmembranes, 503

SAR~AT. M. (see GEIDUSCHEX, E. P.), 541

xii INDEX

SEJUlL, J. (see LIPSCOMB, W. ~.), 423SELLIN, H. G., SRISIVASAN, P . R. & BOREK, E., Studies of a coliphage-induced DXA methylase,

219Serum albumin, bovine, dielectric dispersion, 133SIEGEL, A., HILLS, G. J. & :\IARKHAM, R., In vitro and in vivo aggregation of the defective PM2

tobacco mosaic virus protein, 140SIG~~R, E. R. (see BECKWITH, J. R.), 254- (see Fox, C. :F.), 576SIMJUlOV, B. V. (see I:liGE-VECHTOMOV, S. G.), 583SLUYSER, M., Binding of hydrocortisone to rat liver histones, 591SLY, W. S. (see JO-n.~R, A.), 174S~'YDER, L. (see GElDUSCHEK, E . P .), 541Sodium fluoride and temperature in reticulocytes, effects, 525SOEIRO, R. BlRNlIOlM, R. C. & DJUlNELL, J. E., Rapidly labeled ReLa cell nuclear RXA. II. Base

composition and cellular localization of a heterogeneous RXA fraction, 362- (see WJUlNER, J. R.), 349SOlDLA, T. R. (see INGE-VECIITOMOV, S. G.), 583SOLL, D., JONES, D. S., OHTSUXA, E., FAULKNER, R. D., LOHRMANN, R., HAYATSU, H.

KHORANA, H. G., CHERAYIL, J. D., HAMPEL, A. & BOCK, R. M., Specificity of sRNA forrecognition of codons as studied by ribosomal binding technique, 556

SPEJUlS, C. L. (see KOHN, K. W.), 266Spermine oxidized, inhibitory effect on the multiplication of coliphage T5, 120SRINIVASAN, P. R. (see SELLIN, H. G.), 219STAEHELlN, T. & MESELSON, M., Determination of streptomycin sensitivity by a subunit of the

30 s ribosome of Escherichia coli, 207STElTZ, T. A. (see LIPSCOMB, W. N.), 423STEWJUlT, F. H. C. (see FRASER, R. D. B .), 580Streptomycin sensitivity and the structural components of the 30 S ribosomes ofEscherich ia coli, 211- -, determination by a subunit of the 30 s ribosome of Escherichia coli, 207SUNDJUlJUlAJAN, T . A. & THACH, R . E., Role of the formylmethionine codon AUG in phasing

translation of synthetic messenger RNA, 74Super-suppressor induced interallelic complomentation, 583Suppressor sRNA, fractionation, 202

T5 (see coliphage), 120T-even bacteriophage early messenger in vitro, selective synthesis, 541TASHIRO, Y. [soe SABATI~I, D. D.), 503THACH, R. E. (see SUNDARJUlAJAN, T . A.), 74Thiogalactoside transacetylase, its role in lactose metabolism, 576Tobacco mosaic virus protein, PM2 strain, in vitro and in vivo aggregation, 140Transduction of lac by '1'80 and inversion of the lac operon in Es cherichia coli, 254Transfer RNA's, tyrosine, from Escherichia coli and yeast, species specificity, 161Transforming activity of nitrogen mustard-crosslinked D~A, 28!JTRAUB,P., HOSOKAWA, K., NOMUBA, M., Streptomycin sensitivity and the structural components

of the 30 s ribosomes of Escherichia coli, 211TRAUB,P., NOMURA, M. & Tu, L., Physical and functional heterogeneity of ribosomal proteins, 215Tu, L. (see TRAUB, P.), 215TuCCI, A. F. (see BARANY, M.), 483Turnip yellow mosaic virus, particle weight, 52- - - -, structural similarity of art.icial and natural top components, 223Tyrosine transfer RNA's from Escherichia coli and yeast, spocies specificity, 161

Ultraviolet-irradiated polyuridylic acid, excision ofdirners and hydrates by pancreatic ribonuclease,303

- light causing an abnormal metabolic response in a recombination deficient mutant of Escherichiacoli K12, 442

Virus, defective PM2 tobacco mosaic, protein, in vitro and in vivo aggregation, 140-, turnip yellow mosaic, particle weight, 52-, - - -, structural similarity of artificial and natural top components, 223

INDEX

WANG, J. C. & DAVIDSON, N ., On the probability of ring closure of lambda. DNA, 469WARNER, J. R., The assembly of ribosomes in HeLa cells, 383-, GIRARD, :\1., LATHAM, H . & DARNELL, J . E., Ribosome forma.tion in HeLa cells in the absence

of protein synthesis, 373WARNER,J. R., SOEIRO, R., BIRNBOI:II, H. C., GIRARD, M. & DARNELL, J. E., Rapidly labeled HeLa

cell nuclear RNA, I. Identification by zone sedimentation of a heterogeneous fractionseparate from ribosomal precursor RNA, 349

WATERS, L. C. & DURE, L. S., III. RNA synthesis in germinating cotton seeds, 1WEATHERALL, D. J. (see CLEGG, J. B.), 91Wobble hypothesis for codon-anticodon pairing, 548

Xenopue laeois, size distribution and stability of DYA·like RKA synthesized during developmentof anucleola.te embryos, 399

YeOBt tyrosine transfer RKA, species specificity, 161

ZINDER, :X. D. (see LODISH, H. F .), 333ZOMZELY, C. E., ROBERTS, S., BROWN, D. :\f. & PROVOST, C., Cerebral protein synthesis.!.

Physical properties of cerebral ribosomes and polyribosomes, 455