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This Country Paper titled “Inclusive Engineering Innovations for Transforming Society: An India Approach” on the theme Bio-inspired Engineering Systems was presented at the Federation of Engineering Institutions of South and Central Asia (FEISCA) Regional Seminar on “Innovative Technologies for Excellence in Engineering” at Colombo, Sri Lanka on 10 October 2014. Dr. L V Muralikrishna Reddy, FIE, Int. PE Vice President, The Institution of Engineers (India)
Transcript

This Country Paper titled “Inclusive Engineering Innovations for Transforming Society: An India Approach” on the theme Bio-inspired Engineering Systems was presented at the Federation of Engineering Institutions of South and Central Asia (FEISCA) Regional Seminar on “Innovative Technologies for Excellence in Engineering” at Colombo,

Sri Lanka on 10 October 2014.

Dr. L V Muralikrishna Reddy, FIE, Int. PE Vice President, The Institution of Engineers (India)

Inclusive Engineering Innovations for Transforming Society: An India Approach

Bio-inspired Engineering Systems

Dr. L V Muralikrishna Reddy, FIE, Int. PE Vice President, The Institution of Engineers (India)

Acknowledgements

Er. S L Garg, President FEISCA & Past President, IEI Er. Navin B Vasoya, Member FEISCA Executive Committee

Er. T M Gunaraja Chairman, IEI-TNSC Er. Sandeep B Vasava Member, IEI Council NDRF & IEI TEAM

Presentation Outline and Outcomes

Interdisciplinary Engineering; Inclusive Innovations for Societal Needs; Future Engineering Challenges

Bio-inspired Engineering; Collaborative Research; Medical Engineering

Bio-inspired Materials; Tissue Engineering; Bio-3D Printing

Biosensors; Nano Biosensors; Applications

Biomimetic Engineering and Systems; Synthetic Biology

Innovative Applications and Products

Medical Device Development Platforms

IEI and NDRF Initiatives

Conclusion

The Institution of Engineers (India)

This image cannot currently be displayed.

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Professionals – Academia – Industry - Government

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Largest Multidisciplinary Professional Body with 15 Engineering Divisions and 6 Interdisciplinary Fora

Professional Body of Engineers participating in Engineering Advancement for Nation Building over 95 Years

Incorporated by the Royal Charter in 1935; 7.6 Lakhs of Members; 104 Centres in India and Abroad; 1000+ Student and Technician Chapters; International Bilateral Agreements

Promotes Engineering Activities for Social Impact: Research and Development; Sustainable Technologies; Engineering Education & Accreditation; Certification of Engineering Professionals; Skill Development

Institutional Building; Safety and Quality; Water Management; Rural Development

Significance of FEISCA Regional Seminar

IESL: Apex Body for Engineers in Sri Lanka and Host Organization

FEISCA Member Nations (Bangladesh, India, Nepal, Pakistan, and Sri Lanka)

Regional Seminar: Innovative Technologies for Excellence in Engineering

FEISCA India Team is actively promoting cooperation with National Governments, Regional and International Agencies, regional cooperation in deploying Science and Technology for societal development

FEISCA is playing a major role in promoting cooperation and exchange of information among Member Nations on aspects involving promotion of engineering

FEISCA is an effective platform for networking and collaboration for common problems of Engineers and Society

Engineering: Relevance to Societal Development Engineering symbolizes the understanding and application of Nature; interface between Sciences and Technology & Society and Nature

Provides Solutions and Products to Society utilizing Resources from Nature

Engineering profession is at the forefront for developing solutions for societal needs

Transformation of interdisciplinary engineering knowledge into solutions, products, and services is essential for a Nation’s long-term productive growth and prosperity

Emerging trends show increasing overlap between Biology and Engineering - Healthcare and Sustainability

Engineering Innovations -Ushering Revolutions in India

White Revolution

Green Revolution Rockets, Satellites and Inter-Planetary

Missions

Indigenous Aircraft Carrier

ICT

INS Arihant

Nuclear Power Plant

Chandrapur -Padghe HVDC

Railways Connecting India

Future Engineering Challenges as Others See…

Make solar energy economical Provide energy from fusion Develop carbon sequestration methods Manage the nitrogen cycle Provide access to clean water Restore and improve urban infrastructure Advance health informatics Engineer better medicines Reverse-engineer the brain Prevent nuclear terror Secure cyberspace Enhance virtual reality Advance personalized learning Engineer the tools of scientific discovery

Eradicate extreme poverty and hunger

Achieve universal primary education

Promote gender equality and empower

women

Reduce child mortality

Improve maternal health

Combat HIV / AIDS, malaria and other

diseases

Ensure environmental sustainability

Global partnership for development

Grand Challenges for Engineering

Millennium Development Goals

National Academy of Engineering United Nations

Biology and Engineering can effectively address these Challenges and create Significant Societal Impact

Changing Paradigm - Interdisciplinary Engineering…

Today’s Complex Engineering Systems require interdisciplinary inputs

Need to Integrate Knowledge across multiple branches of science, engineering, and society

Transformation of Concepts and Technologies to Products for Societal Applications

Mechanical Engg.

Mechanical Engg.

Chemical Engg.

Chemical Engg.

B io log ica l S YS TE M S

B io te ch n o logy

n a n o p a rticle sI N TE RFA CE S

p ro s th e tics

Materials Science &

Engg.

Materials Science &

Engg.

Electrical Engg.

Electrical Engg.

B io m a te ria ls

p o lym e rs

Computer Science &

Engg.

Computer Science &

Engg.

Information Communication

Technology

Information Communication

Technology

r o B o tics

c lin ica l D e cis io n s u p p o rt s ys te m

c om p u ta tio n a l

B io logy

B io m im e tics

r o B o tics D e vice s& p h oto n ics

& &p o in to f c a re D ia g n o s tic

G E N E D E LIVE RY

T IS S U E E N G IN E E RIN G

p ro D u cts

Indian Engineering for the Changing Society Success Stories across multiple engineering sectors-Agriculture, Telecom, ICT, Space, Defense, Pharma, and Healthcare

Advantageous 3”D”s - Largest Democracy, Demographic Dividend (60% of population in 24-35 years), strong Domestic Demand; presence in global markets

Researchers are proactively deploying technologies emanating from applied research areas such as Bio-inspired Engineering, Bio-mimicking, Brain-Machine Interface to critical areas like Health & Hygiene; and Food & Agriculture

¼ of India’s population is under the poverty line; 70% are in the rural areas; Women population is around 46%

IEI-NDRF are striving to develop innovations and solutions that are pro-poor and address the needs of the society at the Bottom of the Pyramid

We live in a World Shaped by Engineering Engineering’s Ubiquity Makes it the Key to Society’s Health, Happiness, Safety, and Progress

Engineering “Surrounds” Us

Engineering “Connects” Human Society

Engineering Creativity that “Designs” the World We Want and Turns Ideas into Reality

The overlap of scientific knowledge with societal need, or the application of scientific knowledge to the needs of society is the domain of engineering

Engineering Contribution

Water

NAT

UR

AL

WO

RLD

M

an M

ade W

orld

Water

Earth

Air

Plants

Animals

Man Made World

Man Made World

Achievement of Engineering Profession

Engineers “Gift” to Mankind-Internet…

Democratized Knowledge

Conquered Time and

Distance

Established Global Links Engineers will Enable a “Border-Less” World

Professional Experience and Expertise of Fellow Engineers can be accessed across Borders: Growth and Progress of Engineering Profession

Google Images

Collaborative innovations and knowledge-networking enhance the pace of innovation leveraging the power of Information Technology. With ICT, engineers are in a position to unleash the contemporary paradigm of innovations-”intelligent Innovations”

Bioengineering-Collaborative and Interdisciplinary…

Food

Agriculture

Health care

Clothing

Aerospace

Shelter

Energy

Chemical

Bioengineering focuses on integrative applications bridging Engineering, Biology, and Physical science; and solves challenges left unanswered by Engineering and Physical / Life Sciences disciplines individually

Integrating Engineering with Life Sciences

Bio-Processing Environment Biomedical

Biodegradable products

Biotechnology

Food Processing and Safety

Synthetic Biology

Medical Equipment

Biomaterials

Tissue Engineering

Pharmaceuticals

Brain - Machine Interface

Biosensors

Biomimetics

Biodegradable products

Biotechnology

Food Processing and Safety

Synthetic Biology

Engineers and Medical Tools

Engineering “Design Under Constraints”

Engineering “Design Under Constraints”: Laws of Nature, Desires of Consumers, Applications, Aesthetics, Legal Provisions-all determine the optimum configurations

Medical Electronics encompasses a wide range of healthcare products-personal medical devices, bio-physical monitoring, life support systems, implants, bionics in rehabilitation of physically challenged, embedded technology in neuro sciences (stroke recovery), cardiac sciences, and telemedicine

Increased early detection of problems implies improved patient care and better patient outcomes

Technologies Driving Innovations

Dept. of Biotechnology,

Min. of S&T, GoI

Dept. of Bioscience

and Bioengg.,

IISc..

NDRF(C)

DRDO

IITs

NCBS

Sri Chitra Tirunal Institute

Bio-inspired Materials, Biomaterials and Bio-3D Printing

Biosensors

Biomimetic Systems

Interdisciplinary Research Collaborations

Bio-inspired Engineering

Bio-inspired Materials and Biomaterials & Bio-3D Printing: Development of biomimetic materials that dynamically adapt to their environments for energy and environmental applications, creation of targetable, self-assembling nanotechnologies for efficient drug delivery applications

Bio-3D Printing: Integrates biology and engineering to manufacture living tissue that mimic the function and form of native tissues

Biosensors: Function as analytical tools in socially relevant areas such as agriculture, environment monitoring, biomedical research, amongst several others

Biomimetic Microsystems: Engineering microsystems that replicate complex human organ-level functions for use in drug testing, diagnostic and therapeutic applications

Applications

Bio-inspired Engineering

Smart Therapies

Home Healthcare Devices

Bio-compatible Implants

3D-Printed Organs

Engineered Heart Cells Biosensors

Reference: Google Images.

&Bio-inspired Engineering addresses “un-met challenges” making a difference to the world &Bio-inspired Engineering is richly collaborative and interdisciplinary

Bio-inspired Engineering Happening Places

Department of Atomic Energy

Department of Science & Technology

Department of Biotechnology

Indian Council of Medical Research

Department of Scientific and Industrial Research

Defence Research and Development Organization

Government An Illustrative List…

Council of Scientific and Industrial Research (CSIR) Laboratories

IC-IMPACTS, Canada

National Chemical Laboratory

National Design and Research Forum

DRDO Laboratories

Research Organizations Indian Institute of Science

Indian Institutes of Technology

Jawaharlal Nehru Centre for Advanced Scientific Research

National Institutes of Technology

University of Agricultural Sciences

University of Mysore

Bangalore University

Jain University

Sri Sathya Sai Institute of Higher Learning

Academic Institutions

Aagami Lifesciences Catalysts

Apollo Telemedicine Networking Foundation

AstraZeneca Bangalore

Corporates Avestha Gengraine Technologies

Biocon Ltd.

Biotechnology Industry Research Assistance Council (BIRAC)

Fortis Clinical Research Ltd. (FCRL)

Mitra Biotech Private Ltd.

Strand Life Sciences Private Limited

Bio-inspired Materials

Unique Features

Productization Examples

Natural materials such as bone, shell and wood comprise of limited number of basic components

Develop a wide range of mechanical properties by hierarchical structuring

Resultant materials have a variety of mechanical properties-combining high stiffness and toughness, self-healing, optical functions

Velcro Fastening System based on the structure of cocklebur is incorporated in several products-clothing, medical equipment, and packaging

Self-cleaning paint incorporating the “lotus effect”–ability of the structure of the lotus leaf to repel dirt–approximately USD 120 Mn. Business

Applications for Bio-inspired Materials

Bio-inorganic Materials (Biomineralization)

Bio-inspired Structural Materials (Chiral

Morphologies)

Bio-nanomaterials (Bio-nano Particles)

Hybrid Organic / Inorganic Implant Materials

(Bone-like Composites)

Smart Biomaterials

Biomaterials

Intraocular Lens

Cochlear Replacements

Substitute Heart Valves

Vascular Grafts

Biomaterial technology encompasses concepts of medicine, biology, chemistry, tissue engineering, and materials science

Alumina Cellulose Collagen (Reprocessed)

Commonly Used Biomaterials

Silicone Rubber

Stainless Steel

Dacron Hydrogels Polyurethanes

& First Generation: INERT-Does not trigger any reaction in the host: neither rejected nor recognition

& Second Generation: BIOACTIVE-Ensure a more stable performance over a long time or for the period required

&Third Generation: BIODEGRADABLE-It can be chemically degraded or decomposed by natural effectors (weather, soil bacteria, plants, animals)

Biomaterials - An Emerging Field…

http://ocw.mit.edu/courses/materials-science-and-engineering/3-051j-materials-for-biomedical-applications-spring-2006/

Next generation of medical implants and therapeutic modalities Interface of biotechnology and traditional engineering Significant industrial growth in the next 15 years - potential of a multi-billion dollar industry

& Physical Requirements : Hard Materials, Flexible Material

& Chemical Requirements: Must not react with any tissue in the body; non-toxic to the body; Long-term replacement must not be biodegradable

Tissue Engineering

Tissue Engineering is an interdisciplinary field that integrates principles of biological and chemical sciences, with engineering to realize the objective of tissue generation

Burn Healing

Toxicology Testing as Alternative to Animal Testing

Development of Differentiated Tissue Material for Surgical Procedures

Wound Repair as in Foot Ulcers

Drug Delivery

Commonly Used Biomaterials

Natural Polymers Biodegradable Synthetic Polymers Silk Biospun Scaffolds Injectable Polymers

h ttp &&&w w w &in te ch op e n&com &B ooks&B iom ate ria ls&S CIE N CE &A N D&e n gin e e rin g&n e w &D e ve lop m e n ts&IN&TIS S U E &E N GIN E E RIN G&of&m icrova s cu la r&p roS TH E S E S

Tissue Engineering: Need of the Hour…

Fewer livers available for transplant than there are patients waiting for new livers

A strategy for construction of the organ must be developed

Tissue engineering holds the promise of producing better organs for transplant

Using tissue engineering techniques and gene therapy it may be possible to correct many otherwise incurable genetic defects

Tissue engineering holds the promise of replacing damaged or diseased tissues and organs. The use of autologous donor cells is often not feasible because of the limited replicative lifespan of cells, particularly those derived from elderly patients

3D Printing at NDRF

Rapid Prototyping facility at “Proto Lab Centre” at NDRF is currently utilized by AMIE Students, Engineering Students and other R&D Laboratories

Bio-3D Printing

Bio-3D Printing integrates biology and engineering to manufacture living tissues that mimic the function and form of native tissues. Bio-3D Printing can produce tissue in various shapes

Manufacture Biological Systems (Cartilage, Bone, Organs), Nanostructures, Combinations of Different Materials (Metal-Plastic), and Fibre-Reinforced Components

Potential in Wound Healing, Organ Regeneration, Tissue Engineering, and Development of Prosthetic Limbs

Uses Bioink, mixture of stem cells

Printer moves back and forth dropping out one Bioink particle at a time to form one layer

Printer prints out one layer of cells at a time on Biopaper, which is made up of collagen, water, and hydrogels

Layers are printed one top of each other

After cells fuse, biopaper is removed

Sensors Roadmap

Biosensors…

Biosensors are playing a major role as analytical tools in socially relevant areas such as agriculture, environment monitoring, biomedical research, amongst several others

Biosensors are being deployed in several applications because they are specific in detection. The selectivity of biosensors increases significantly without making the device complicated and expensive

Range of Sensors

Odour, Toxic Gases

Pathogens

Pesticides, Poison

Artificial Nose, Bio Sensors

Biosensors, MEMS

Chemical Sensors, MEMS

&In areas that have suffered disasters that disrupt physical and social infrastructure significantly, a wide range of toxins, pathogens, and contaminants can emerge rapidly from multiple sources and threaten victims and rescuers alike. &Biosensors can help disaster-recovery personnel and disaster victims identify and avoid health threats endemic to disaster areas, reducing disasters' human and economic costs.

…Biosensors…

Biological Material

Integrated Analytical Devices

Transducing Microsystem

Tissue

Micro-organisms

Organelles

Cell Receptors

Enzymes

Antibodies

Nucleic Acids

Optical

Electrochemical

Thermometric

Piezoelectric

Magnetic

Schematic of Biosensors

…Biosensors…

Applications of Biosensors

DNA sequencers, mass spectrometry

Drug delivery

Bionics

Information capture

Affinity microarrays for DNA, proteins

Biosensors

Biological lab on chip, electrophoresis

&The Schematic Diagrams shows the Outline of Bio Sensors. &It has many applications like Clinical diagnosis and biomedicine, fermentation control and analysis food and drink ,Microbiology: bacterial and viral analysis, Pharmaceutical and drug analysis, Industrial effluent control , Pollution control and monitoring o Mining, industrial and toxic gases, Military applications, etc.

Biosensors for Societal Applications

Biosensor systems for hygiene and sanitation at rural level and detection of antibiotic resistant bacteria in food and water samples

Major Objectives Development of bio-sensing

system for food hygiene and sanitation

Detection of antibiotic resistant bacteria

Adenosine triphosphate (ATP) bioluminescence based assays will be performed for rapid monitoring of food hygiene and sanitation.

ATP bioluminescence based assays will be performed for the pre-screening and rapid quantification of multidrug resistant bacteria/pathogens.

Recombinant bacteriophage harbouring lux gene cassette against specific superbug strain/bacterial pathogen will be constructed.

Cloning and expression of lux gene cassette in conjugation to inducible stress promoters will be carried out to detect the presence of hazardous materials present in the environment.

Field applicable, handheld and battery operated optical biosensor system will be developed for onsite monitoring of pathogens/toxins in the environment

Biosensors for Societal Applications - NDRF Case Study-1

Woldman et al, Free radical Biology and Medicine, Vol. 47, pp 1339-1345 (2009)

Reproduced Using Commercially Available Proteins

Development of a Sensor for Detection of Nitric Oxide

Proof-of-concept

Production and Purification of the required components of the System

Detection

Stability studies

Biosensor hardware studies

Prototype fabrication and testing

time s (each interval is 7.8s)

Phot

ocur

rent

Biosensors for Societal Applications - NDRF Case Study-2

Scope of the Project Development of Simulation Model for Biosensors using Experimental Data from Nitric Oxide Biosensor for Model Validation

Biosimulation-computer-aided mathematical simulation of biological processes

Biosensor project “Biosensor for Detection of Nitric Oxide (NO) using its natural receptor Guanylyl Cyclase” generated idea to build simulation model to ease experimentation and cut costs

Build the simulation model for a nitric oxide biosensor based on open source software COPASI,Celldesigner, Jdesigner and Genesis Validate the models generated by the opens source software with the experimental data

Nano Biosensor

What is the Principle?

Development of nano-biosensor for ammonia detection for use in micro air vehicles

How to improve the sensitivity and Response speed?

Carbon Nanotubes (CNTs) Why CNTs & What is their novelty?

Mediate faster electron transfer between the redox center of the linked enzyme (bioreceptor) & the electrode

AlaDH (enzyme) Pyruvate + NADH + NH4+ → L-alanine + NAD+ + H2O +2e-

Electrons will be transferred to electrode & signal will be detected by connecting the electrode to an Amplifier

Olfactory Sensor

Olfactory System in Humans

Olfactory receptors are located on the cilia of olfactory neurons inside the nose

When odorant molecules bind to the receptors the neurons are activated and an electrical signal is sent out to its corresponding glomeruli, located in the olfactory bulb

The glomeruli are activated to relay a signal to the brain

Biomimetics: Biological and Artificial Olfactory Systems

“Hero” / Artificial Nose? DRDO, IISc, IITs, NCBS, NDRF(C), bigtec

Sl. No. STEP BIOLOGICAL ARTIFICIAL

1 Acquisition of Vapour phase molecules

Muscular Diaphragm Inhalation

Sniff Pump (SSPL)

2 Interaction with Sensing materials Nasal Cavity Sensor Head (DRDE)

3 Transduction (Converting molecular information to electrical)

Olfactory Receptors Polymer Sensor (DMSRDE / DRDE / SSPL)

4 Transmission to analyzer Neuronal Electrical

5 Information Decoding and recognition

Olfactory bulb and cortices

Computer Chip (DRDE / Anurag)

6 Output Biological reaction Control circuit and display (DRDE / Anurag)

7 Storage Brain Computer memory

Synthetic Biology

Synthetic biology

Biomaterials

Biosensors

Biofuels

Diagnostics

Therapeutics

Biomedicine Bioremediation

Food Ingredients

Fine Chemicals

Physics

Engineering Science Biology

Computer Science

Chemistry

Biological Inspiration

Biological systems outperform, in every aspect, small manmade aircraft

Direct mimicry of flapping motion is very challenging

Thin, under cambered wings are more efficient than those with substantial thickness

Birds and bats have flexible wings

Nature does not have access to all mechanisms, such as propellers

Fixed, flexible wings can provide a practical platform for MAVs driven by propellers

10-4

10-

3 1

0-2

10-1

1

1

01 10

2 1

03 1

04

105

106

Reynolds Number

Gro

ss W

eigh

t (k

g)

UAV

F-18

Aerodynamics

Low Reynolds Number Regime

Increase in Profile Drag Reduction of CL Max Reduction in Lift / Drag

ratio

At low Reynolds numbers:

Aerodynamic Performance - Reduced

Use of Coanda effect to increase lift

Unsteady aerodynamics and gusts

Insect Flight aerodynamics Vortex Flows

CFD - ADE, NAL, JNCASR, IISc, CRL (Tata)

103 104 105 106 107 108

Model of the Flapping Body used in the Simulations

Numerical Investigations of Unsteady Aerodynamics

Experimental Setup

Development of large scale unsteady 3-Dimensional simulations tools for insect flight using mesoscale methods Evaluate usefulness of LB and its variants for transient, 3-D

simulations Building of computational model to replicate experimental results.

Symmetric Flapping at Re =1000 Asymmetric Flapping at Re =1000

Vorticity contours obtained from an asymmetrically flapping forward flight (advance ratio = 0.8) simulation at Re = 1000 after 2 cycles

JNCASR, NDRF

CFD Analysis

Aerodynamic Analysis of Flexible Flapping Wing MAV

Experimental Setup

Side View Top View

Replication of Flapping Wing Model

NDRF, NCBS, DC Enterprises

Bio-inspired Perching Mechanism

Perching mechanism in natural fliers has evolved over millions of years of evolution over all the three forms of habitats viz. on land (terrestrial), arboreal (on trees) as well as on water (aquatic). It is used for both landing and takeoff

Perching mechanism for Drones is under Research based on Biological models

An NDRF Initiative

Insect Aerodynamics

Insect Studies

Soap Nut Bug

Kinematics of wing motion is studied under stroboscope to understand the development MAV’s. Natural Flight is a biological activity however it is inter-disciplinary.

An NDRF Initiative

BORG GROUP

NP-MICAV Projects Involved Development Of Beetle Cyborg – SITAR (Proposed)

BORG GROUP

Projects Proposed Engineering insects for discovering people trapped under rubble – University of Agricultural Sciences, Raichur

Ionic Polymer Metal Composites (IPMC) as Flapping Actuators – NAL

NDRF - CYBORG GROUP

Insect Cyborgs will solve the flight duration problem since insects like moths and beetles can fly longer naturally.

The challenge is to control them and enhance their sensing capabilities by carrying micro/nano cameras or olfactory sensors with transmitters.

No external power is required for flight but micro-energy sources will still be required for the micro/nano electronics.

Innovative Models for Affordable Healthcare

Context NDRF Approach to Deliver Affordable

Healthcare-Medical Device Development Platform Initiative

Healthcare across all South Asian countries is expensive and there is a need to reach out to all sections of society

India is being seen as the hub for “medical tourism”

This presents an opportunity for innovation to roll-out affordable healthcare solutions

NDRF (Consortium) is working in a collaborative mode to develop a “Web-enabled Mobile Diagnostic Platform with knowledge-base (Clinical Decision Support System) This is connected to a Call Centre at the District / State Level. Face to Face interaction with a Clinician and patient is possible in these networked centres Through this network, patient will receive an electronic prescription and obtain the prescribed medication Under R&D: Non-invasive Diagnostic Platform on a “Tablet”

High-tech Innovations to Cost-Effective Point-of-Care (PoC) Medical Devices…

Technology Drivers

Sri Chitra Tirunal Institute; IITs; Defence Bioengineering and Electromedical Laboratory, Bangalore; NDRF(C); Society for Biomedical Technology and

others are working in this exciting area…

Cost-effective medical devices and instruments for screening and diagnosis at the "Point-of-Care“ is seen as a "building-block" of a viable and effective healthcare delivery system

The proliferation of telecom has catalyzed the convergence of telecom and healthcare sectors, providing a useful take-off point for innovations in healthcare

There is a trend to integrate healthcare devices with consumer products so that the device fits snugly onto the patient’s body, and does not alter the individual’s daily routine. This will help manage patients manage their diseases effectively

…High-tech Innovations to Cost-Effective Point-of-Care (PoC) Medical Devices…

NDRF is progressing the Indian Council of Medical Research funded project on “Development and Manufacture of Non-Invasive Glucometer”, a device for measuring blood glucose & HbA1C levels in diabetic patients without utilizing an actual blood sample

Unique Features:

Eliminates the “per-test” expenditure for assessing the blood glucose level

Does not require piercing of fingertip and obtaining of blood

Is painless, and does not generate biological waste, thereby reducing the risk of spread of dangerous diseases

NIR Emitter & Silicon Photo-detector

…High-tech Innovations to Cost-Effective Point-of-Care (PoC) Medical Devices…

Innovative Blood Pressure Measurement Devices using Innovative Methods to Replace Pressure Cuff

It is a wearable device like a watch Product is small, handy and easy to use Unobtrusive, and can be incorporated in regular daily activities of the

individual Needs no prior training to use Facilitates continuous monitoring at regular intervals Stores information Wi-fi device that connects to the Internet There are no motors etc. like in the BP measuring device presently available

in the market

ICT in Healthcare…

Progress made by the Indian IT industry, bioinformatics, chemo-informatics, computer aided design (CAD), and imaging techniques can be leveraged to enhance Indian healthcare system.

Research is on in several organizations to integrate databases of literature-based and practice-based evidence for clinical decision support and developing the system architecture for Electronic Health Record Compliant Clinical Decision Support Systems

IBM's Report "Improving India's Healthcare System" through Information Technology presents the Point of View that the adoption of advanced, well-established IT can help improve Indian healthcare system.

Inner circle depicts IBM's recommendations. Outer circle depicts the likely benefits.

Source: INAE Report: Technologies for Healthcare in India

…ICT in Healthcare…

GOVERNMENTAL INITIATIVES National Rural Health Mission National Health Portal of India Indian Health Information Network

These programs present significant opportunity for researchers, academicians, entrepreneurs, and the Industry to collaborate with the Government to deploy contemporary technologies like Cloud, Big Data, and Analytics

Brain-Computer Interface

Brain-Computer Interface (BCI) Technology allows a human to control a devices with thoughts Picks up electrical signals in the brain using

electrodes and converted into data that is used to control devices Brain-Computer Interface is a frontier

technology that is likely to assist the mobility of elderly patients afflicted by Alzheimer's and Parkinson's diseases and enhances the quality of life of the senior citizens

Brain Machine Interface

Brain Machine Interface

Electro Myograph (EMG) based Control of Machines

Brain Machine Interface

Ocular Dipole (OD) Control of Machines

Brain Machine Interface

Electro Encephalograph (EEG) Control of Machines

India’s Pioneering Engineering Professional Body is promoting interdisciplinary research in the collaborative mode

Interdisciplinary Research is the way forward to improve medical care

IEI’s engagement with WFEO to deploy technologies in the context of UN Millennium Development Goals

IEI’s R&D Grant-in-Aid Scheme

IEI promoting strong Academia-Industry interactions

NDRF’s contemporary laboratories-Rapid Prototyping Laboratory and the Central Integrated Systems Laboratory-benefit to AMIE

AMIE’s Outcome-Based Education Approach

NDRF looks forward to engaging with practitioners to take forward viable ideas for further R&D and Productization

Promotes Research, Design, Development, Productization, and Innovation through collaborative effort since 1969

Pioneered the Consortium Approach for Engineering Research in India, integrating User Organizations, Funding Agencies, Research Organizations, Academia, Industry, and Entrepreneurs

Anchors interdisciplinary technological research in many engineering disciplines including for societal applications

Plays a major role in deploying engineering and technology services, systems, and solutions for nation building

Collaborative Ecosystem for Design and Research

National Design and Research Forum (NDRF)

Biomimetic and Biosensors [bigtec, Abexome, CSIR-Central Food Technological Research Institute, NDRF (Consortium), Dept. of Biosciences and Bioengineering, IISc., Biosensor Society of India]

Cyborg Group [SITAR, NAL, IISc, Inst. Of Wood Sc., Univ. of Agri. Sc. Raichur, Jain Univ., Industry]

Brain Computer Interface [IISc, DEBEL, Industry]

Quantum Well Infrared Photo detectors (QWIPs) [IISc, BEL, SITAR]

National Programme on Micro Air Vehicles (NP-MICAV) [ADE, NAL, IITB, IITK, NDRF(Consortium) Partners]

PISAT - Student built Satellite Initiative [ISRO, VTU, PESIT]

System Identification Group: Flapping Wing MICAVs [IISc, NAL, ADE, JNCASR, CAIR, NCBS, MSRSAS, Industry]

Bird Strike Research [DGCA, BIAL, Academia]

Autonomous Under Water Vehicles [NIOT, NRB]

NDRF Research Focus

9 International Patents, 12 Monographs, Papers in Journals

Central Integrated Systems Laboratory (CISL)

Bio-simulation Research Focus

Simulation and Design applied to Simulation of Process in Biosensors

Mechanisms and Consequences of Cell activation in micro-circulation

Pulsatile Blood Flow in the Lung Studied as an Engineering System

Biomechanics of Injury and Healing

CISL is envisaged to be a National Resource Facility for AMIE students to develop expertise in systems-engineering and design of multidisciplinary systems by simulation

CISL is established at NDRF

Encompasses different engineering disciplines–mechanical, civil, electrical, electronics, computers, Chemical, bio-engineering etc.

Support by ARDB-DRDO, DST, AICTE, ISRO, CSIR etc.

Create a strong expertise in systems-engineering and the design of multi-disciplinary optimization areas

Tomorrow’s Engineers…

Tomorrow’s Engineers must be able to synthesize a broad range of

interdisciplinary domain inputs and related engineering concepts, while

maintaining focus on the overall "systems" perspective

Conclusion

Engineering is becoming a “Border-less” Profession

Collaboration is the Mantra for Progress

Engineers have to become “World-class” Professionals

IEI is striving to promote the cause of Engineering Profession in India

IEI is keeping abreast of all developments taking place at the national and International levels in the areas of advanced technologies, and is attempting to develop applications at an affordable cost for solving societal problems


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