UNIVERSITY OF CALICUT (Abstract) B.Sc programme in Industrial Chemistry under Choice based Credit Semester System (UG) - Course structure and Modified syllabus– approved – implemented from 5 th semester onwards effective from 2009 admission – Orders issued. GENERAL & ACADEMIC BRANCH-IV ‘J’ SECTION No. GA IV/J2/4911/10 Dated, Calicut University PO, 12.05.2011 Read:1. U.O.No.GAI/J2/3601/08 Vol:II dated 19.06.2009. 2. U.O.No.GAI/J2/8423/07 dated 03.02.2010. 3. Minutes of the meeting of the Board of Studies in Industrial Chemistry held on 08.03.2011. 4. Orders of the V.C in the file of even number. O R D E R As per U.O. read as 1 st , Choice based Credit Semester System was implemented to all UG programmes in affiliated Colleges of the University with effect from 2009 admission onwards. Vide paper read as 2 nd , the Core Courses for I and II semesters of B.Sc programme in Industrial Chemistry was implemented from 2009 admission onwards. The Board of Studies in Industrial Chemistry, vide paper read as (3) resolved to implement the modified syllabus from 5 th semester of B.Sc Industrial Chemistry programme onwards effective from 2009 admission . The Vice-Chancellor considering the exigency, exercising the powers of the Academic Council, approved the minutes subject to ratification by the Academic Council. Sanction has therefore been accorded for implementing the course structure and modified syllabus from the 5 th semester of B.Sc programme in Industrial Chemistry with effect from 2009 admission. Orders are issued accordingly. Syllabus appended. Syllabus is available in University website also. Sd/- DEPUTY REGISTRAR (G&A-IV) For REGISTRAR To The Principals of affiliated colleges offering B.Sc programme in Industrial Chemistry. Copy to: PS to VC/PA to Registrar/Chairman, Board of Studies in Industrial Chemistry/ CE/EX Section/DR III/DR PG/EGI/ Enquiry /System Administrator (With a request to upload in the University website)/Information Centres/ GAI ‘F’ ‘G’ sections/GA II/GA III. Forwarded/By Order SECTION OFFICER
Transcript
UNIVERSITY OF CALICUT(Abstract)
B.Sc programme in Industrial Chemistry under Choice based Credit Semester System (UG) - Course structure and Modified syllabus– approved – implemented from 5th semester onwards effective from 2009 admission – Orders issued.
GENERAL & ACADEMIC BRANCH-IV ‘J’ SECTION
No. GA IV/J2/4911/10 Dated, Calicut University PO, 12.05.2011Read:1. U.O.No.GAI/J2/3601/08 Vol:II dated 19.06.2009.
2. U.O.No.GAI/J2/8423/07 dated 03.02.2010. 3. Minutes of the meeting of the Board of Studies in Industrial Chemistry held on 08.03.2011. 4. Orders of the V.C in the file of even number.
O R D E R
As per U.O. read as 1st, Choice based Credit Semester System was implemented to all UG programmes in affiliated Colleges of the University with effect from 2009 admission onwards.
Vide paper read as 2nd, the Core Courses for I and II semesters of B.Sc programme in Industrial Chemistry was implemented from 2009 admission onwards.
The Board of Studies in Industrial Chemistry, vide paper read as (3) resolved to implement the modified syllabus from 5th semester of B.Sc Industrial Chemistry programme onwards effective from 2009 admission .
The Vice-Chancellor considering the exigency, exercising the powers of the Academic Council, approved the minutes subject to ratification by the Academic Council.
Sanction has therefore been accorded for implementing the course structure and modified syllabus from the 5th semester of B.Sc programme in Industrial Chemistry with effect from 2009 admission.
Orders are issued accordingly. Syllabus appended. Syllabus is available in University website also.
Sd/- DEPUTY REGISTRAR (G&A-IV)
For REGISTRARTo
The Principals of affiliated colleges offering B.Sc programme in Industrial Chemistry.
Copy to: PS to VC/PA to Registrar/Chairman, Board of Studies in Industrial Chemistry/CE/EX Section/DR III/DR PG/EGI/Enquiry /System Administrator (With a request to upload in the University website)/Information Centres/GAI ‘F’ ‘G’ sections/GA II/GA III.
Forwarded/By Order
SECTION OFFICER
UNIVERSITY OF CALICUT
B. Sc PROGRAMME IN INDUSTRIAL CHEMISTRY
(RESTRUCTURED CURRICULUM)
UNIVERSITY OF CALICUTRESTRUCTURED CURRICULUM FOR B.Sc. PROGRAMME
IN INDUSTRIAL CHEMISTRYCourse Structure (Total Credits : 120)
Introduction :
The name of the course is ‘B . Sc INDUSTRIAL CHEMISTRY’
The course is designed to include 80 % syllabus of B. Sc Chemistry of Calicut University
along with special topics related to Industry in theory and practicals. The successful
candidates will be eligible to pursue post graduate studies in and allied subjects also
including M.Sc. chemistry.
The course will be for six semesters following the general undergraduate pattern. Each
student will have to carry out a project work under the supervision of a teacher nominated
by the Head of Department in an Industrial establishment or in a research Institute or in
the College. The candidate shall submit two duly certified copies at the end of the final
semester to the examiner. Viva Voce will be based on the project report. For the
evaluation of the Industrial Chemistry papers and Practicals, a separate examination
Industrial Chemistry II 5 Hrs. VI 90 46 IC5B08(Pr)
ICIIIC6B14(Pr)
A) Project and viva voce
B) Project/ Factory visit
2 Hrs.
2 Hrs.
V
VI
36
36
2
2
Scheme of Instruction
For the B.Sc. Industrial Chemistry programme, Chemistry forms
the core course. It is to be taught during all the six semesters. Both
theory and practicals are included for study during the six semesters.
A. Theory
The total number of core theory courses is eleven, one course
each during the first four semesters, three courses each during fifth
and sixth semesters and one elective course in the sixth semester.
In the fifth semester under open course for students from other
streams, three courses are prescribed.
1. Environmental chemistry
2. Chemistry in everyday life
3. Plastics and rubbers in everyday life
In the sixth semester the elective course is Modern Aspects of
Chemistry
B. Practical
Practicals corresponding to each core course will be conducted
during the corresponding semesters. A combined examination relating
to the first four core course practicals will be held at the end of the
fourth semester. Other core course practical examination will be held
at the end of sixth semester. All practical examinations are of three
hour duration. A duly certified record of practicals should be submitted
during the examination.
C. Project
Project works will be carried out in fifth and sixth semesters (two
hours per week). Not more than ten students can form a group and
undertake a project. Each individual student should submit a copy of
the project report duly attested by the supervising teacher and the
Head of the department.
SEMESTER I - CORE COURSE I
FOUNDATIONS IN CHEMISTRY (36 HOURS)
CREDIT – 2 (2HOURS/WEEK)
Module 1: Methodology and Perspectives of Sciences (6 hours)
Types of knowledge: Practical, theoretical and scientific knowledge. What is science? –What is not science? – Hypothesis – theories and laws in science – observations, evidences and proofs.Science as a human activity, scientific temper vocabulary of science – science disciplines. Revolutions in sciences and technology.
References1. Gieryn T. F Cultural Boundaries of Science Univ. Chicago Press 1999.2. Collins H and T. Pinch “The Golem what everyone should know about science” Cambridge Univ. Press 1993.3. Hewitt, Paul G, Suzanne Lyons, John A Suchocki and Jennifer Yeh Conceptual Integrated Science Addison – Wesley, 2007.4. Jeffrey A Lee The Scientific Endeaver: A premier on Scientific principles and practice Pearson Education
Module II: Methodology in chemistry (12 hrs)
General introduction – history and development of Chemistry – different branches of Chemistry – relevance of chemistry in everyday life. Applications in different fields - industry, agriculture, food, medicine, textile, building materials (paint, cement etc), plastics, rubber, etc. Power generation by chemical methods such as fission and fusion reactions - solar cells, biofuel , feed stocks sugar/ starch/plant and animal fats biodiesel. Some chemically and biologically important systems, water-its unique features, hydrogen bonding etc. Mention about metals, nonmetals and metalloids, combination of atoms. Different types of bonding (ionic, covalent, coordinate). Comparison of physical properties with chemistry. Organic Chemistry- Chemistry of Carbon compounds catenation – isomerism – vital force theory – purity of organic compounds – classification – functional group – biomolecules – natural products –The concept of polymers, supramolecules and nanomaterials in chemistry.
Module III: Periodic classification (9 hrs)
Modern periodic law – long form periodic table – Periodicity in properties – Atomic, ionic, covalent radi – ionisation potential, electron affinity, – Electronegativity – Paulings, Mulliken, Allred Rochow's Scale of electronegativity. Radius ratio – Effective nuclear change – Screening effect – Slater rules Anomalous behaviour of 1st element of a group – diagonal relationship.Module IV: Nuclear Chemistry (9 hrs)
Natural radioactivity – Modes of decay – group displacement law – theories of disintegration – Rate of decay – Decay constant – Half life period – Gieger Nuttal rule – Radioactive equilibrium – Disintegration series – Transmutation reactions – using
protons, deutrons, -particles and neutrons – Artificial radioactivity – Positron emission and K electron capture – Synthetic elements. Nuclear stability – N/P ratio – Packing fraction – Mass defect – binding energy – nuclear forces – exchange theory and nuclear fluid theory – Nuclear fission – fusion – hydrogen bomb – atomic bomb – nuclear reactor. Isotopes – detection – Aston's mass spectrograph – separation of isotopes – Gaseous diffusion method – thermal diffusion method – Application of radioactive isotopes – 14C dating – rock dating – isotopes as tracers – study of reaction mechanism (ester hydrolysis) – Radio diagnosis and radiotherapy.
References
1. C.N.R.Rao - Understanding Chemistry , University Press(India) Pvt.Ltd.2. Puri, Sharma & Kalia, principles of Inorganic Chemistry, Milestone Publishers and Distributors, 2008.
SEMESTER II – CORE COURSE IITHEORETICAL CHEMISTRY (36 HRS)
CREDIT – 2 (2HRS/ WEEK)
Module I (9h)
Dawn of Quantum TheoryIntroduction based on historical development – John Dalton's atomic theory, earlier from models. Failure of classical physics – black body radiation, Plank's quantum hypothesis, photoelectric effect, generalisation of quantum theory. Bohr theory of atom – calculation of Bohr radius, velocity and energy of an electron. Atomic spectra of hydrogen and hydrogen like atoms. Limitations of Bohr theory. Sommerfeld modification. Louis de Broglie's matter waves – wave-particle duality. Electron diffraction. Heisenberg's uncertainty principle.
Module II (9h)
Introductory Quantum Chemistry Operator algebra – linear and Hermitian operators, Laplacian and Hamiltonian operators, eigen functions and given values of an operator. Postulates of quantum mechanics. Well behaved functions. Time independent Schrödinger wave equation. Application to particle in a one dimensional box – normalization of wave function. Particle in a three-dimensional box – separation of variables, degeneracy. Application of Schrödinger wave equation to hydrogen atom. The wave equation in spherical polar coordinates (mention only). Separation of variables. Radial and angular functions. Orbitals. Quantum numbers (n, l, m). Radial functions and Radial distribution functions and their plots, Angular functions and their plots (1s, 2s and 2pz only). Need for approximation methods in multi-electron systems.
Module III (9h)
Bonding in diatomic molecules Born-Oppenheimer approximation. Variation theorem (mention only). Quantum mechanical concept of bonding – LCAO approximation. Valence bond theory of H2
molecule (Derivation not required). Molecular orbital theory of H2+ molecule (Derivation
not required). Potential energy diagram of H2 molecule formation – equilibrium geometry. Bonding and anti bonding molecular orbitals, bond order. MO diagrams of homo nuclear and hetero nuclear diatomic molecules – He2, Li2, Be2, B2, C2, N2, O2, F2, CO and NO. Comparison of VB and MO theories.
Module IV (9h)
Bonding in polyatomic moleculesConcept of Hybridisation: Definition, need of hybridization. LCAO of the central atom – coefficients of atomic orbitals in the linear combination (derivation not required). sp hybridization – BeH2, sp2 hybridisation – BH3, sp3 hybridisation – CH4. Application of hybridization concept – geometry of molecules like PCl5, SF6 and IF7. Bonding in metals:Qualitative idea of free electron approximation and tight binding approximation. Formation of bands in a one-dimensional solid. Fermi level. Explanation of electrical properties using these models.
Reference Texts:1. D.A. McQuarrie and J.D. Simon, Physical Chemistry – A Molecular Approach,
Viva, 2001.2. A.K. Chandra, Introduction to Quantum Chemistry, Tata McGraw-Hill, 1994.3. R.K. Prasad, Quantum Chemistry, 2nd Edition, New Age International, 2000.4. Day and Selbin, Theoretical Inorganic Chemistry, East West Press, 2002.5. Manas Chanda, Atomic structure and the Chemical Bonding, Tata McGraw Hill, 2007.
3. D.A. McQuarrie, Quantum Chemistry, University Science Books, 1983.
4. Jack Simons, An Introduction to Theoretical Chemistry, Cambridge University
Press, 2005.
SEMESTER 3CORE COURSE III
PHYSICAL CHEMISTRY I (54 HRS)
CREDIT 3(3 Hrs/WEEK)
Module I: Gaseous State (12 Hrs)
Kinetic molecular model of gases – Maxwell distribution of velocities and its use in calculating molecular velocities (average RMS and most probable) and average kinetic energy - Colhsion diameter, meanfree path and viscosity of gases including their pressure and temperature dependence – Relation between mean free path and coefficient of viscosity – Behaviour of real gases – deviation of gases from idea gas behaviour – Compressibility factor – Van der Waal's equation of state it's derivation and application in explaining ideal gas behaviour – virial equation of state – Van der Waals equation exposed in virial form and calculation of Boyle temperature – Isotherms of reals gases and their comparison with Van der Waal's isotherms – Continuity of State determination of molecular mass by limiting density method – critical phenomena – critical constants and determination.
Module II : Liquid State (6 hrs)
Vapour pressure – determination of V.P. Surface Tension – determination – Parachar – determination application to structure elucidation of compounds viscosity – determination of molecular mass from viscosity measurements – refraction – refractive index – molar refraction and optical exaltation – application to structure elucidation.
Module III : Thermodynamics (18 hrs)
Definition of thermodynamic terms – types of systems – intensive and extensive properties – State and path functions – Zoroeth law of thermodynamics.
First law of thermodynamics – concept of heat, work, internal energy and enthalpy
– heat capacity relation between Cp and Cv – Expansion of an ideal gas – work done
– in reversible isothermal and adiabatic expansion – calculation of W, q, E,
– H for expansion of an ideal gas under isothermal and adiabatic conditions –
– Reversible isothermal expansion of a real gas – Jaule Thomson effect –
– Liquifacticin of gases – derivation of the expression for Joule Thomsan
– coefficient – Inversion temperature.
Second law of thermodynamics – Limitations of first law and need for second law – different statements of the law – Carnot cycle – efficiency of a heat engine – Carnot theorem – Concept of entropy – Entropy changes in isothermal expansion of an ideal gas – Entropy changes in phase changes – Calculation of entropy change of an ideal gas with change in P, V and T – Entropy changes of an ideal gas in different processes – entropy of mixing – standard entropies. Work and free energy functions – Maxwell relationships – Criteria for reversible and irreversible processes – Gibbs – Helmboltz equation – Partial molar free energy – Concept of chemical potential – Gibbs Duhem equation – Clapeyron equation – Clapeyron – Clausins equation – Its application.Concept of fugacity and Concept of activity and activity coefficient.
Third law of thermodynamics – Nernst heat theorem – statement of third law – Concept of residual entropy – and absolute entropies (Elementary idea only).
Module IV : Statistical Thermodynamics (9 hrs)
Need for statistical approach – Permutations and combinations – Distribution – Probability – Relation between entropy and probability – Sterling approximation – Types of particles – Bosan, Fermian, Boltzmannans – Microstate – most probable distribution – derivation of Maxwell – Beltzmann distribution law – Statistical weight factor (gi) definition of partition function Q – Relation between thermodynamic functions and Q Molecular partition functions (q) factorisation of Parhhan function – derivation of translational Parhhan function and calculation of entropy and internal energy, by translational mode.
Module IV : Chemical Equilibria (9 hrs)
Law of mass action equilibrium constant – Relation between Kp, Kc and Kx – Thermodynamic treatment of the law of mass action – Vant Hoff sreaction isotherm
– Temperature dependence of the equilibrium constant – The Van't Hoffs equation
– Pressure dependence of the equilibrium constants Kp, Kc and Kx – Study of heterogeneous equilibria – Factors that change the state of equilibrium – Le Chattier's principle and its application to chemical and physical equilibria.
References
I. Text Books
1. Puri Sharma Pathania, Physical Chemistry.
2. R.L. Sani Dharmaraha, Physical Chemistry.
3. Neggi, N.L., Physical Chemistry.
4. Gurdeep Raj, Physical Chemistry.
II. Reference Books
1. Daniels, Albery, Physical Chemistry.
2. Maare, W.J., Basic Physical Chemistry.
3. Gordon M. Barrow, Physical Chemistry, Tata McGraw Hill Edition, 1992, Vth ed.
4. K.L. Kapoor, Physical Chemistry, Vol. I, II, III, IV.
5. Glastone, A Text book of Physical Chemistry.
6. Rastogi, Introduction to Chemical Thermodynamics.
7. Rajaram and Kuriakkose, Chemical Thermodynamics.
8. Atkins, Physical Chemistry.
SEMESTER IV
CORE COURSE IV
ORGANIC CHEMISTRY – I (54 hrs )
CREDIT 3(3 Hrs./WEEK)
Module I : Hydrocarbon I (9 hrs)
Structure and Bonding of alkanes. Hybridisation and shapes of simple molecules – methane, ethane, ethylene, acetylene – polarity of bonds – Inductive effect, electromeric effect, hyperconjugation, resonance, steric effect – rules for resonance forms and techniques of drawing resonance forms – curved arrow formalism – nomenclature of alkanes – source of hydrocarbons – methods of formation – Wurtz reaction, Kolbe reaction, Corey-House reaction and decarboxylation – Properties of alkanes – oxidation and chlorination.
Module II : Hydrocarbon II (9 hrs)
cis-trans isomerism of cycloalkanes – conformation of ethane, n-butane – Newman projection Saw-horse formula, Fischer and flying wedge formula – Conformation of cycloalkanes – ring strains in cyclopropane and cyclobutane –Bayers strain theory – conformations of mono substituted cyclohexane. Alkynes: Nomenclature – Preparation – Elimination of dihalides – Alkylation of acetyldeanoin (preparation of higher alkynes) – Reactions – Addition of HX, H2O, reduction and oxidative cleavage – Acidity of alkynes.
Module III : Introduction to organic reaction mechanisms (9 hrs)
Hydrocarbons III: Nomenclature – industrial preparation and uses of alkenes – calculation of degree of unsaturation – cis-trans isomerisms – E-Z designation – electrophilic addition reaction – mechanism of addition of hydrogen halides and halogen to alkenes – Markownikoff's rule – Peroxide effect – mechanisms. Synthesis from alcohols and alkyl halides. Reactions: conversion to alcohols by hydroboration, oxymercuration, hydrogenation, halohydrin formation, cis-hydroxylation, ozonolysis and oxidation with HIO4. Industrial applications of ethylene and propylene – Preparation of polymers. Important natural products – with structure and uses of terpenoids citral, germinol, vitamin A, limonene (Structural elucidation not required).
Module IV : Alkenes (9 hrs)
Types of organic reactions – polar reactions and radical reactions – types of reagents – electrophiles and nucleophiles – reaction intermediates – carbocation, carbanions, free radicals, carbenes, nitrenes (with examples) – their structure, hybridisation stability and reactions (one each).
Module V : Stereochemistry (9 hrs)
Critical activity – Specific rotation and enantiomeric excess – chirality and elements of symmetry – enantiomers –diastereomers – lactic acid, glyceraldehyde - tartaric acid - aldotetroses- DL and R-S configurations.Meso compounds – Racemic mixtures and resolution – optical isomerism of compounds without asymmetric carbon atoms – Allenes and biphenyls – asymmetric synthesis.
Module VI : Benzene and Aromaticity (9 hrs)
Nomenclature – structure and stability of benzene – molecular orbital description – Aromaticity and Huckel's rule – Naphthalene, Anthracene – Haworth synthesis of naphthalene. Reactions of benzene. Electroplhilic substitution reactions with mechanism – Halogenatin, nitration, sulphronation, Friedel-Craft's reaction orientation effect of substituents – Nitration and sulphonation of naphthalenes with mechanism. Oxidation and reduction of aromatic compounds – side chain oxidation, catalytic hydrogenation of aromatic rings.
Text Books :1. John McMurry – Fundamental of Organic Chemistry. Brook and Cole. 2. Bruice – Organic Chemistry, Pearson Education, New Series 2001, 3rd edition. 3. Mark Louden – Organic Chemistry, Oxford University Press, Oxford.
References 1. L.G. Wade, J.R., Organic Chemistry, Pearson Education, Singapore, 2004, Vth Edn.2. Solomons & Fryhle, Organic Chemistry, Wiley India Pvt. Ltd., 2004, VIIth ed.3. I.L. Finar, Organic Chemistry, Vol. I & II, ELBS with Longman, Singapore, 1973, VIth edition.4. Morrison & Boyd, Organic Chemistry, Prentice Hall of India Pvt. Ltd., New Delhi, 1998, VIth ed. 5. Bhal & Bhal, Adv. Org. Chemistry.6. Tiwari, Mehrothra, Vikas & Vishno, Text book of Organic Chemistry.7. M.K. Jain, Principles of Organic Chemistry.
SEMESTER V - CORE COURSE VINORGANIC CHEMISTRY I (54 HRS)
CREDIT – 3 (3HRS/WEEK)
Module 1 (9 hrs)
Chemical Bonding Ionic bond – Lattice energy of ionic compounds - Born-Lande equation – Born-Haber cycle – its applications – Lattice energy – solubility – polarisation of ions – Fajan's rules. Covalent bond: Valance bond theory – hybridisation – sp, sp2, sp3, sp3d and sp3d2
Polarity of covalent bond – percentage of ionic character – dipole moment and molecular structure.
Module 2 (12 hrs)
Representative elementsGeneral characteristics of S block elements – electronic configuration, size, density, ionisation energy, melting point, boiling point, flame colour. General characteristics of P block elements – Electronic configuration, size, oxidation state, ionisation energy, electron affinity, electronegativity. Preparation, properties and structure of diborane, borazine, boric acid, boron nitride and interhalogen compounds (ClF, ICl3, ClF3, IF5 and IF7). Electropositive character of iodine – separation of noble gases (charcoal adsorption method).
Module 3 (12 hrs)
MetallurgyOccurrence of metals based on standard electrode potential – concentration of ores – calcination, roasting and smelting – reduction using carbon and other reducing agents – electrolytic reduction – hydrometallurgy – Ellinmgham diagram. Reforming of metals – electrolytic refining – oxidative refining – zone refining – Van Ankel method. Extractive metallurgy of Li, Ni, Ti and U – Ferrous metallurgy – manufacture of steel by open hearth process – Alloys – types.
Module 4 (9 hrs)
Transition and innertransition elementsTransition metals – Electronic structure – metallic characters – oxidation states – size – density – melting an d boiling points – ionisation energy – colour – magentic properties – reducing properties – catalytic properties – Non stoichiometric compounds – complex formation – alloy formation – difference between first row and other two rows.Lanthanides – Electronic configuration and general characteristics – occurrence of lanthanides – separation by ion exchange method – lanthanide contraction.Actinides – Electronic configuration and general characteristics – comparison with lanthanides.
Module 5 (12 hrs)
Theoretical principles of qualitative and quantitative analysisApplications of solubility product and common ion effect in the precipitation of cations – Interfering acid radicals and their elimination (oxalate, fluoride, borate, phosphate, chromate, arsenite and arsenate). Primary and secondary standards – standard solutions – theory of titrations involving acids and bases, KMnO4, K2Cr2O7, I2 and liberated I2. Indicators – Theory of acid-base, redox, adsorption indicators – complexometric titrations. Precipitation methods: Conditions of precipitation – coprecipitation and post precipitation and washing of precipitates.
SEMESTER V CORE COURSE VIINDUSTRIAL CHEMISTRY –I(54 HRS)
CREDIT 3 (3HRS/WEEK)Module I (5 Hrs)
Unit process, unit operations, flow diagrams, Energy balance and material balance (basic concepts only). Fuels, calorific value, Basic concepts of I S O
Module II (5 Hrs)
Fluid flow, stream line flow. Turbulent flow, viscosity –Reynold’s number.Newtonian and non Newtonian liquids. Heat transfer. Types of heat exchangers. (Shell type and plate type.)Refrigeration cycles. Safety in chemical industry. First aids. Module III (3 Hrs)
Basic concepts –branched and network polymers. Classification and nomenclature . Properties of polymers. Mol wt. glass transition temperature solubility and viscoelasticity. Manufacture and uses of PF resins.Importance of polymers in controlled drug delivery and packaging.Polymer processing, compounding ( blending, moulding, casting, drawing, rolling).Conducting polymers. PA, PPP, PPg(SN)x etc. Synthetic inorganic polymers, silicones, polyphosphazenes,-manufacture and application. Module – V (5 Hrs)
Soaps and detergents-Basic chemical compositions of soaps, manufacture (Cold, semi boiled and full boiled processes).Surface active agents, builders, additives, fillers. Basic concepts of perfuming and colouring. Bio-degradability.Cosmetics – basic concepts – composition – production and classification of creams –sunscreen and suntan lotions –deodorants talcum powder – dentifiers, lipsticks.
Module VI (5 Hrs)
Food processing –colouring and flavouring agents, food preservation –viscosity builders –bulking agents, artificial sweetners – food adulteration –packaging and catering.
Module VII (7 Hrs)
Fundamental concepts or theory and industrial application of particle size analyzer spectrophotometry –flame, photometry –AAS -Xray flouorescence ion selective electrodes –chromatography.- Chromatographic methods for separation, concentration and characterization of organic compounds – Column chromatography, Paper, TLC & Gas – Liquid Chromatography.
Module VIII (5 Hrs)
Effluent treatment –principles of aerobic and anaerobic effluent treatment –adsorption –filters –sedimentation ,electrostatic methods –wet scrubbers –mist eliminators –brief idea of about waste recycling and its importance, solid waste management
Module IX Dyes (10 Hrs)
Basic Concepts, Classification –methods of dyeing –acid –direct -reactive –disperse –vat cationic sulphur –indigo –azo phthalocyanine –dyes. Synthetic Dyes A brief idea of metal complex dye stuffs. ( introduction to natural dyes and it’s importance in cotton textile dyeing.) fluorescent and brightening agents. Paints –varnishes and lacquers. Non textile uses of dyestuffs Health hazards.
References:
1. Nano Science And Technology.- V.S Muraleedharan –A Subramannian –Ane books put Ltd2. Unit process and chemical engineering- Chathopadhyaya3. Chemical Process Principles – Hougens4. Industrial Chemistry – B K Sharma5. Cosmetics preparation and practice – vandana publications6. Hand book of cottage industries – Small Business publications7. Industrial effluents – Manivasakam8. Food Chemistry – B Sreelakshmi9. Food chemistry – L H Meyer10. Instrumental methods of analysis – Williard Merit,dean,settle11. A text book of polymer science – Bill Meyer,12. Polymer Science V R Gowariker,N V Viswanathan,sreedhar13. Text Book of Environmental chemistry and Pollution-S S Dara
SEMESTER V - CORE COURSE VIIPHYSICAL CHEMISTRY – II (72 HOURS)
CREDIT 3 (4 HRS./WEEK)
Module I : Solid State (18 Hrs)
Law of constancy of interfacial angles – Law of constancy of symmetry – Law of rationality of indices – space lattice and unit cell – Miller indices – seven crystal systems and fourteen Bravais lattices. X ray diffraction – Bragg's equation – Derivation. Brief description of rotating crystal method and powder method. Analysis of powder diffraction patterns of NaCl, CoCl and KCl. Detailed study of simple, face centered and body centered cubic systems.
Calculation of Avogadro number – Identification of cubic crystal from interplanar ratio. Close packing of spheres – packing of spheres in body centred cubic arrangement – Structure of ionic compounds of the type AX (NaCl, CsCl, ZnS), AX2 (CaF2 TiO2).
Defects of crystals. Non stoichiometric and stoichiometric defects. Point defects, Shottky defect and frental defects Extrinsic and intrinsic conduction – Liquid crystals is classification and its applications (Theory not required).
Module II : Molecular Symmetry and Group Theory (9 Hrs)
Elements of symmetry of molecules – Identify – proper axis of rotation, reflection plane, inversion centre, improper axis of rotation – Schenflies rotation – Combinations of symmetry operations – Mathematical group – Point conditions – groups pf simple molecules – CnV, Cnh, Dnh. Group multiplication table for C2v, C3r and C2h.
Module III : Molecular Spectroscopy (18 Hrs)
Interaction of electromagnetic radiation with matter – Energy levels in molecules.
Rotational spectrum – rigid rotator – expression for energy – selection rule – determination of bond length of diatomic molecules – calculation of bond length, moment of inertia.
Vibrational spectra: of diatomic molecules – simple hormone oscilator – selection rule – Vibrational modes of CO2 and H2O – calculation of force constant.
Raman spectroscopy: Brief description. Stokes and anti stokes lines and their intensity difference – Rotational Raman spectrum and its selection rules – Mutual exclusion principle.
Electronic spectroscopy : Frank condon principle – Dissociation energy of diatomic molecule.
NMR spectroscopy: Principle – number of signals, position of signals – chemical shift, intensity of signals, spin-spin coupling, NMR spectra of simple organic molecules.
ESR spectroscopy : Theory – hyperfine splitting of methyl radical.
Module IV : Solutions (9Hrs)
Kinds of solutions and methods for expressing concentration – Molarity, molality, mole fraction, normality, mass fraction, parts per million – Ideal solutions – Raoult's law. Solubility of gases in liquids – Henry's law. Pressure – composition and temperature – Composition diagrams – deviation from ideal behaviour for completely miscible liquid systems – Fractional distillation – Colligative properties – Relation between Colligative properties and Molecular mass (Thermodynamic derivation not needed). Abnormal molecular mass – Vaut Hoff factor.
Module V : Phase equilibrium (9Hrs)
Phase rule Equilibrium between phases. Thermodynamic derivation of phase rule – One component systems – Water system and sulphur system – Two component systems – Simple eutectic systems – Head silver system, KI water system – Freezing mixtures. Thermal analysis and desilverisation of lead solid liquid equilibria involving congruent and incongruent melting points – Mg-Zn system – FeCl3 – H2O system and Na2SO4 water system. Solid Gas equilibrium. Dehydration of copper sulplhate pentahydrate. Deliquence and Eflorescence (mentioning only). Three component systems – ChCl3-H2O-HOAc system.
Liquid-liquid-equilibrium – partially miscible and immiscible liquid systems – CST – upper CST and lower CST – Steam distillation – Distribution law and its thermodynamic derivation – Applications.
Module VI : Surface Chemistry & Adsorption (9 Hrs)
Physical and chemical adsorption – Adsorption isotherms – Langmuir Fruendlich and B.E.T. equations (B.E.T. no derivation) – Gibbs adsorption equation – Surface films – Mathematical derivation – Determination of surface area using Langmuir and B.E.T. equations.
Colloids: Types and classification – preparation of colloids – purification – protective colloids – kinetic, optical and electrical properties – surfactants – Gels – Emulsions. Properties and applications. Zeta potential Donnan membrane equilibrium – Dorn effect.
References:
1. Text books for study
i) B.R. Puri, L.R. Sharma & M.S. Pathania, Principles of Physical Chemisstry, Vishal Publishing Co., Jalandhar.
ii) P.L. Soni, O.P. Dharmarha & U.N. Dash, Text book of Physical Chemistry, 22nd
Edn., Sultan Chand & Sons, New Delhi.
2. Books recommended for reference
i) L.V. Azaroff, Introduction to Solids, McGraw Hill.
ii) N.B. Hanna, Solid State Chemistry, Prentice Hall.
iii) Colin N. Banwell & E.M. McCash, fundamentals of Molecular Spectroscopy, Tata McGraw Hill Publishing Company Ltd., New Delhi.
iv) G.K. Vemula Palli, Physical Chemistry, Prentice Hall of India.
xii) C.N.R. Rao & J. Gopalakrishnan, New Directions in Solid State Chemistry, Cambridge University Press, 1997.
xiii) R. Stephen Berry Stuart A. Rice & John Ross, Physical Chemistry, Oxford University, Oxford University Press, 2007, 2nd Ed.
xiv) R.C. Ropp, Solid State Chemistry, Els 08.
SEMESTER VI - CORE COURSE VIIIORGANIC CHEMISTRY II (54hrs)
CREDIT – 3 (3Hrs./WEEK)
Module I : Halogen Compounds (9 Hrs)
Nomenclature of alkyl and aryl halides – preparation of alkyl halides – from alcohols and alkenes. Radical halogenation, alkylic bromination of alkenes – preparation of aryl halides.Reactions of alkyl halides: Substitution reactions, SN1 & SN2 – Mechanism, Kinetics, Energy profile diagram & Stereochemistry. Reactions of vinyl & allyl halides – elimination of alkyl halides – E1 & E2 mechanism – Saytzeff rule. Reactions of Aryl halides – Nuxcleophilic aromatic substitution reaction with mechanism – bimolecular displacement mechanism – Elimination – addition mechanism and Addition – elimination mechanism – Benzyne intermediate.
Module II : Organometallic compounds (9 Hrs)
Preparation of Grignard reagent, Organolithium compounds, Organo zinc compounds, Organo copper compounds. Reformatsky reaction – Synthesis of organic compounds using Grignard reagent and alkyl lithium. Alcohols: Nomenclature – Preparation of alcohols – By reduction of carbonyl compounds – reaction of carbonyl compounds with Grignard reagent – Properties of alcohol – Hydrogen bonding – Reactions of alcohols – Dehydration, Conversion to tosylates – Oxidation.
Module III : Phenols (9 Hrs)
Preparation (from cumene, aromatic sulphonic acid, chlorobenzene). Properties – Acidity of phenol – uses – reactions (oxidation) to quinones, Riemer-Tiemann reaction – Bromination, Nitration, Liebermann nitroso reaction, preparation of phenolphthalein, Kolbe's reaction – Pinacol – Pinacolone rearrangement. Ethers and Epoxides Nomenclature – Preparation – Williamsons Synthesis – Alkoxy mercuration of alkenes – Reactions of ethers – Acidic cleavage, Claisen rearrangement, Zeisel's method of estimation of methoxy groups – crown ether structure and importance in organic synthesis – Epoxides – Nomenclature – Preparation from alkenes and halohydrins – Reactions – ring opening reactions – acid catalyzed and base catalysed reactions.
Module IV : Aldehydes and Ketones (9 Hrs)
Nomenclature – Nature of carbonyl group – Preparation – oxidation of alcohols – ozonolysis.Reactions: Oxidation (with CrO3, Ag2O and KMnO4) – Reduction Wolf Kisner, Clemmenson reduction, metal hydride reduction – Nucleophilic addition (hydration – bisulphite addition, HCN addition).Hemi acetal and acetal formation – carbonyl – alpha substitution reaction – Keto-enol tautomerism – enolate ion formation – haloform reaction – alkylation of enolate ion –
carbonyl condensation reaction – Perkin reaction, clavin schmidth reaction, Stoth condensation – general mechanism reaction with hydroxylamine, hydrazine, phenylhydrazine, 2,4 DNP and semi carbazide – study of name reactions with mechanisms – Aldol condensation – Cannizaro reaction – Claisen condensation and benzain, Beckmann rearrangement – Synthesis of capro lactum – preparation of vanillin and acrolein – distinction between aldehydes and ketones.
Module V: Carboxylic acids and derivatives (9 Hrs)
Nomenclature – effect of substituent on acidity of aliphatic and aromatic carboxylic acids – Preparation of monocarboxylic acids – oxidative cleavage of alkenes – hydrolysis of nitriles – carboxylation with Grignard reagent – side chain oxidation of alkyl benzenes – reaction of carboxyfic acids – fischer esterification reaction – mechanism HVZ – reaction – decarboxylation – preparation and reactions of acid derivatives – acid chlorides – esters, amides and anhydrides – mechanism of saponification – reaction of cinnamic acid – preparation of Aspirin from salicylic acid – Dicarboxylic acids – Preparation and reactions of malonic acid – adipic acid, phthalic acid – structure of citric acid.
Module VI : Pericyclic Reactions (9 Hrs)
Featurs – M.Os of conjugated TI systems – FMOS – Electrocyclic reaction – Mode of rotations – analysis of odd and even number of electron pair(s) systems with FMO method – cycloaddition reaction – modes of addition – Dulo-Alder reaction – Analysis with FMO method – Sigmatropic rearrangement – [1,3] and [1,5] re-arrangements – Cope and Claisen rearrangements – mechanisms. Pericyclic reactions in human body – Vitamin D from cholesterol.
Text Books 1. John McMurry – Fundamental of Organic Chemistry. Brook and Cole. 2. Bruice – Organic Chemistry, Pearson Education, New Series 2001, 3rd edition. 3. Mark Louden – Organic Chemistry, Oxford University Press, Oxford.
References 1. L.G. Wade, J.R., Organic Chemistry, Pearson Education, Singapore, 2004, Vth Edn.2. Solomons & Fryhle, Organic Chemistry, Wiley India Pvt. Ltd., 2004, VIIth ed.3. I.L. Finar, Organic Chemistry, Vol. I & II, ELBS with Longman, Singapore, 1973, VIth edition.4. Morrison & Boyd, Organic Chemistry, Prentice Hall of India Pvt. Ltd., New Delhi, 1998, VIth ed. 5. Bhal & Bhal, Adv. Org. Chemistry.6. Tiwari, Mehrothra, Vikas & Vishno, Text book of Organic Chemistry.7. M.K. Jain, Principles of Organic Chemistry.
SEMESTER VI CORE COURSE IX
INDUSTRIAL CHEMISTRY II (72 HOURS)
CREDIT 3(4 HRS./WEEK)
Module I (6 Hrs)
Historic Background, Development of pharmaceutical industry in India, Brief idea on IP,BP,USP,EP, and NF. Pharmaceutical jurisprudence. Brief idea on GMP and SOP’s., NABL
Module II (7 Hrs)
Pharmacognosy - Introduction to plant classification and crude drugs. Cultivation, collection, preservation and storage of medicinal plants. Identification of plants –microscopic examination –leaf content and paliside ratio, stomatal number – stomatal index, vein islet number vein termination number –crude fiber content. Evaluation of crude drugs- Loss of drying at 105°C. ash content – acid insoluble ash- sulphated ash-moisture content- extractive value – volatile oil content foreign organic matter. Microscopic examination and estimation of starch.
Module III (5 Hrs)
Phytochemistry – Introduction to phytochemistry –fats -different types of waxes volatile oils – saponins -flavones – flavanoids - tannins glycosides and alkaloids- Isolation procedures for active ingredients – Vinca alkaloid - deosgenin.
Module IV (12 Hrs)
Pharmaceutical Quality Control and Preparation:- Sterility testing pyrogen testing glass testing bulk density of powders. Asceptic condition –need for sterilization - different methods of sterilization. Different routes of drug administration – formulation of drugs – ointments, tablets - capsules – syrup I. P - elixirs, injectables, isotonic solutions Eye preparation.
Module V (6 Hrs)
Pharmaceutical excipients. Glidants, lubricants, diluents, preservatives, antioxidants –emulsifying agents –coating, colouring and flavoring agents –binders viscosity builders –gelatin, use of sorbitol, mannitol and liquid glucose. Surgical dressings sutures, ligatures –pharmaceutical packaging –selection of packaging –packaging material auxiliary materials – packaging machinery quality control of packaging materials.
Module VI (24 Hrs)
Various types of drugs with examples. Basic raw materials, Process of manufacture, mode of action and efficient handling of the following bulk drugs - Sulfa drugs (Sulfamethoxasole) - Anti Microbial Agents (Chloramphenicol, Furazlidine) - Anti Tubercular drugs (Isoniacid, Rifampicin) Analgesics (Salicylic Acid, Paracetamole)-NSAIDS (Ibuprofen, Mefenamic acid) -Steroidal Hormones (progestrone, testostereone), β - blockers ( propranalol, atenalol) -Cardio Vascular agents (methyl dopa, Heparin) - Antihistamines (chloropheneramine maleate, citracene hydrochloride), Anti viral drugs (acilovir )
Module VII (12 Hrs)
Drug design and development –discovery of a drug, discovery of Librium, discovery of penicilin –discovery of lead compounds. Random Screening –non random screening Drug metabolism studies (Brief idea only). The pharmacophore identification modification structural of functional groups structure –activity relationship - structural modification to increase potency. Homologation, chain branching, ring chain transformation – extension of structures –Isosters/ bio – isosters. Quantitative structure activity relationship –The Hammet equation –Taft equation- Drug designing using QSAR computer assistant design –application of other modeling techniques.
References:
1. IP , NF2. Medicinal Chemistry –V K Ahluvalia, Madhu Chpora- Ane books put Ltd –( Page 1 to 19).3. Pharmacognosy –Mohammed Ali4. Pharmaceutical Jurisprudence – M K Jain5. Pharmaceutical Chemistry – Kapoor and Kapoor6. Experimental Methods in chemical analysis7. Industrial Chemistry – B K Sharma8. Environmental Chemistry -S S Dara9. Text book of pharmaceutical organic chemistry –Mohammed Ali - CBS Publishers10. Text book of pharmaceutical organic chemistry- Jayasree Gosh11. Organic Pharmaceutic Chemistry- Harkishan singh and v K Kapoor
SEMESTER VI - CORE COURSE X
PHYSICAL CHEMISTRY III (54 HRS)
CREDIT 3 (4 HOURS/WEEK)
Module I : Chemical Kinetics (12 hours)
Rate of reaction and rate equations. Order and molecularity of reactions. Experimental methods of determining reaction rates – Derivation of integrated rate equations for first and second order reactions – General integrated rate equation for nth order reaction. Zero and fractional order reactions. Characteristics of reactions of zero, first, second, third and nth order. Determination of order. Examples of opposing consecutive and parallel reactions. Qualitative idea of chain reactions. Influence of temperature on reaction rates. Arrhenius equation – Determination and significant of Arrhenius parameters. Collision theory: Derivation of rate equations for bimolecular reaction using collision theory. Collision theory of unimolecular reactions – Lindemann theory – Steady state approximation – Theory of absolute reaction rates – equation and explanation (no deviation).Catalysis: Homogeneous and heterogeneous catalysis – Intermediate compound formation theory and adsorption theory – kinetics of enzyme catalysis – Michaelis-Menten equation (Derivation not required).
Module II : Photochemistry (6 hours)
Grothus – Draper law, Stark-Einstein law – Beer Lambert's law – Quantum yield. Examples of reactions with high and low quantum yield and explanation. Jablonsky diagram – Fluorescence and phosphorescence – Photosensitation – Chemiluminescence – Different between photochemistry and radiation chemistry – Effect of ultrasonic sound and microwave radiation on chemical reactions.
Module III : Electrolytic conductance (12 hours)
Fardays laws – applications – Measurement of conductance – Specific and molar conductance – Arrhenius theory of electrolytic dissociation – Ostwald's dilution law – Variation of conductance with dilution – Debye-Huckel theory and Onsager equation )no derivation) – Debye-Falkenhagen and Wein effect – Ionic mobility and its measurement – In conductances – Abnormal conductance of hydrogen and hydroxyl ions. Kohlrausch's law. Transport number and its determination by Hittort and moving boundary methods – Applications of conductance measurements – Determination of degree of dissociation. Ionic product of water – solubility of sparingly soluble salts – conductometric titrations – Activity and activity coefficients of electrolytes – Ionic strength – Debye-Huckel limiting law – equations only.
Module IV : Ionic Equilibrium (6 hours)
Theories of acids and bases: Arrhenius, Lowry-Bronsted and Lewis theories – Levelling and differentiating solvents – pKa, pKb and pH. Applications of common ion effect and
solubility product – Hydrolysis of salts of all types – Degree of hydrolysis and hydrolysis constant and its relation with kw. Buffer solutions – Mechanism of buffer action buffer index – Henderson equation. Theory of acid-base indicators.
Module V : Electromotive Force (12 hours)
Galvanic cells – Reversible cells – Reversible electrodes – Types of reversible electrodes – Reference electrodes – Standard hydrogen electrode, calomel electrode – quinhydrone electrode – standard electrode potential – Electrochemical services – Nervist equation for electrode potential and emf of a cell. Thermodynamics of cell reactions. Application of Gibbs-Helmholtz equation to Galvanic cells – Calculation of G, H and S. Concentration cells – emf of electrode and electrolyte concentration cells with and without transference (general equation) – Liquid junction potential – Applications of emf measurements – determination of pH, solubility of sparingly soluble salt; potentiometric titrations – Redox indicators – Fuel cell (hydrogen, oxygen fuel cell only) – Polarization and overy polarography – dropping mercury – electrode – significance of half-wave potential and diffusion current – Electrochemical theory of corrosion.
Module VI : Computers in Chemistry (6 hours)
Fundamentals (in common course) – Introduction to C language, C characters, constant and variables – C statements – conditional statement – simple C programs (1) calculation of molecular mass of organic compounds (2) Calculation of normality, molality and molarity (3) Factorial of a number (4) Determination of half life and average life of radioactive element (5) Determination of pH – Introduction to free and open chemistry softwares available in the identical for drawing structures and molecular viewing.
Text Books
1. Puri, Sharma, Pathma, Principles of Physical Chemistry, Vishal Publishing Co.2. Soni & Dharmarha, Text book of Physical Chemistry, Sultan Chand.3. Gurtu & Snohi, Physical Chemistry.4. Gurdeep Raj, Advanced Physical Chemistry, Goel Publishing House. 5. Glasstone & Lewis, Elementary Physical Chemistry, Macmillan.6. Pruton & Maron, Physical Chemistry.7. Daniels & Alberty, Physical Chemistry.8. Balaguruswamy, Programming in C. 9. Yesharant Kanetkar, Let us C, BPB Publishers. 10. K.V. Raman, Computers in Chemistry.
SEMESTER VI
IC6B13 Elective Course
Modern aspects of Chemistry
Module I: Coordination Chemistry (9 hrs)
Werner's theory – Electronic interpretation of co-ordination compounds - EAN rule – types of ligands – Nomenclature, isomerism – stability of complexes – factors influencing stability – Application of coordination compounds in qualitative and quantitative analysis.
Module II: Theories of bonding in coordination compounds – VBT, CFT and MOT (10 hrs)
VBT – merits and demerits – CFT – crystal field splitting in tetrahedral and octahedral complexes – factors affecting crystal field splitting – CFSE of complexes – spectrochemical series – Explanation of geometry, magnetism and colour on the basis of the above theories.
Module III: Nano Chemistry (7 hrs) Introduction – Quantum structures – Nanostructures – synthesis and properties of carbon nano structures – Inorganic nano tubes and nano wires – Oxide nanoparticles – nano composites and nano fibers. Applications of nano technology in catalysis, biology, nano filters, nano switches. Image application, writing with atoms – computing and electronics.
Module IV : Structure determination (4 hrs)
Application of UV, IR, NMR spectroscopic methods to the structural determination of inorganic and organic compounds.
Module V Analytical Techniques and Methods-1 (12) hrs
Analytical Chemistry – scope, functions, analytical process, Sampling – Collection, Preservation and preparation of sample, Techniques of sampling solids, liquids and gases, Operation of drying and preparing a solution of the analyte.
Introduction to Volumetric Method of Analysis:- Calibration of volumetric apparatus, Primary and Secondary standards, Principles of volumetric analysis, Acid – base titration. Titration in non-aqueous solvents, Complexometric titrations, Precipitation titrations, Redox titrations, Theoretical aspects of titration curves and end point evaluation, Choice and suitability of indicators in each case-Non-aqueous titrations - Perchloric Acid, Pot.Hydrogen Phthalate, use of acetic anhydride, crystal violet indicator.
Introduction to Gravimetric Analysis:- Precipitation reactions, conditions of precipitation, nucleation, particle size, crystal growth, colloidal state, ageing, impurities in the analytical precipitate, co-precipitation, precipitation from homogenous solution, drying and ignition of precipitation, Applications.
Module VI (5 hrs)
Solvent extraction Efficiency of extraction, Selectivity of extraction, Extraction system,Method of Extraction, applications. Soxhlet extraction (detection / estimation of metallic elements in ores and alloys. Basic principles and application. Electro analyticalmethods: Polarography, Cyclic voltametry and coulometry and some applications.
Module VII Green chemistry (7 hrs)
Need for Green chemistry – Goals of green chemistry – Limitations. Twelve principles of green chemistry with their explanations and examples – Designing a green synthesis – Prevention of waste / byproducts – Atom economy (maximum incorporation of materials used in the process) – Minimization of hazardous / toxic products – prevention of chemical accidents – Green synthesis – Ibuprofen.
Text Books
1. John McMurry, Fundamentals of Organic Chemistry, Vth Edn., Brooks/Cole.2. Marc Louden, Organic Chemistry, Oxford University Press, Calicut.3. Bruice, Organic Chemistry, 3rd Edition, Pearson Education New Series, 2001.4. V. Kumar, Introduction to Green Chemistry, Vishal Publishing House.
References
1. L.G. Wade, J. Organic Chemistry, Vth Edn, Pearson Education, Singapore, 2004.2. Solomons & Fryhle, Organic Chemistry, VIIth ed, Wiley India Pvt. Ltd., 2004.3. I.L. Finar, Organic Chemistry, VIth edition, Vol. I & II, ELBS with Longman, Singapore, 1973.4. Morrison & Boyd, Organic Chemistry, Prentice Hall of India Pvt. Ltd., New Delhi, 1998, VIth ed.5. B.S Bahl & Arun Bahl, Advanced Organic Chemistry., S.Chand & Co, New Delhi.6. Tiwari, Mehrothra, Vikas & Vishnoi, Text book of Organic Chemistry.Vikas Publishing House, Pvt Ltd, New Delhi.7. M.K. Jain, Principles of Organic Chemistry.8. J.March Advanced Organic Chemistry John Wiley and sons.9. S.H.Pine, J.B.Hendrickson, D.J.Cram and G.S.Hammond Organic Chemistry, Mc Graw Hill.
10. C.N.Pillai Organic Chemistry for undergraduates Universities Press (India) Pvt Ltd, 2008.11. Puri, Sharma and Kalia, Principles of Inorganic Chemistry, Milestone Publishers and Distributors, 2008.12. P.L. Soni, Text book of Inorganic Chemistry, Sultan Chand and Sons, 2007.13. W.D.Eingery, H.K.Dowen and R.D.Uhlman ‘Introduction to Ceramics’ John Wiley.14 R.Gopalan and V.Ramalingam ‘Concise coordination Chemistry’ Vikas publishing House, New Delhi.15. J.D. Lee, Concise Inorganic Chemistry. 5th Edition, Oxford University Press and Delhi, 2008.16. Cotton and Wilkinson, Advanced Inorganic Chemistry, Wiley India Pvt. Ltd., 2008.17. J.E. Huheey,E.A.Keiter and R.L.Keiter , Principles structure and reactivity
UNIVERSITY OF CALICUT
B . Sc Programme in Industrial Chemistry
Course Structure (Practicals) Credits – 20
Sl.
No.
Code No Course Title Hrs./
week
Semes
ter
Tota
l
Hrs.
Cred
its
1 IC1B01(p)
IC2B02(P)
IC3B03(P)
IC4B04(P)
Core Course Practicals – I,
Volumetric analysis. 2 hrs I, II,
III, IV
144 4
2 IC5B06(P) Core Course Practicals – II
Inorganic Mixture Analysis 5 Hrs V 90 43 IC5B07(P) Core Course Practicals – III
Gravimetric Analysis ,organic
Analysis
5 Hrs. V 90 4
4 IC6B11(P) Core Course Practicals – IV
Industrial Chemistry
-IExperiments
5 Hrs. VI 90 4
5 IC6B12 Core Course Practicals – V
Industrial Chemistry II
IIExperiments
5 Hrs. VI 90 4
6 IC5B08(Pr)
IC6B14(Pr)
Project and viva voce
Project/ Factory visit
2 hrs.
2 Hrs.
V
VI
36
36
2
2Syllabus Practicals:
Semester I to IV
Laboratory safety, first aid and treatment of fires
Importance of lab safety – burns – eye accidents – cuts – gas poisoning – electric shocks – poisons – treatment of fires – precautions and preventive measures.Weighing using chemical balance, preparation of standard solutions.
Volumetric Analysis –Acidimetry : Estimations of : Hydrochloric acid, Potassium Carbonate, Mixture of carbonate and bicarbonate.Permanganometry : Estimations of Oxalic acid, iron , Calcium Dichrometry:Estimations of Ferrous iron-Internal and external indicator, reduction of ferric ironComplexometry:Estimations of Zinc, magnesium, Calcium, Mixture of calcium and magnesiumCerimetry:Estimation of ceric ammonium sulphateArgentometry: estimation of chloride –warder’s and winkler’s methodIodimetry and Iodometry:Estimations of Arsenious oxide, copper ( A minimum of 10 experiments to be done)
Semester V
Reactions of anions – Fluoride, Oxalate, phosphate, Borate, Silicate,Tartrate,Arsenate,Arsenite –Demonstration only Inorganic Mixture Analysis involving two anions and two cations with eliminating radicals, borate, fluorides, oxalates.Gravimetric analysis:Estimations of Water of crystallization of barium chloride ,sulphate, barium, Iron,copper, and NickelOrganic analysis:Analysis of functional groups involving acid, aldehyde, ketone, ester, phenol, carbohydrate, sugars ,nitro group, amino group, amide, diamide, and hydrocarbons –Derivative to be suggested only-(Minimum of 10 compounds to be done)
Semester VI Industrial Chemistry Experiments
Viscometry, refractometry, Polarimetry, Conductometry, Potentiometry. Estimation of aniline, phenol, Glucose.Non-aqueous titrations-Sodium benzoate, Isoniazid, diazepam, MebendasoleLimit Test- Chloride, sulphate, iron, leadIodine value, Saponification value (Coconut Oil)Loss of drying of crude drug at 105°C, (Sodium bicarbonate)Ash Value, Sulphated ash, Acid Insoluble Ash, Total Ash, Ash content, Free alkali in soap ,TFMAnalysis of alloys- brass, Bronze, Type metalAssay: Calcium carbonate, Calcium Gluconate, Aspirin, Ascorbic acid, Lactic acid
COD of effluent water, water quality parameters like DO, PH, conductivity refractive index , BOD, bacteriology chromatography( paper or TLC)Total hardness of water , analysis of bleaching powderDistillation, Steam distillation, Soxhlet extraction, use of hot water funnel, crystallization, separations using separating funnel ( Demonstration only).Preparation of toilet soap (Cold Process, semi boiled process), Cold cream ,Vanishing cream, Shampoo(Detergent and soap based,) Pain Balm, lipstick , hair dye talcum powder.
CORE COURSE PRACTICAL-OVERALL GRADE
Core Course Practical-I (Volumetric Analysis)
Questions Grades awarded WeightageVolumtricProcedure writing and weight calculation
Correct wt. Calculaion :, Correct Link solution preparation of std. solution,Standardisaton of link,Estimation,I ndicator and end pointA-6 Points B:4 points C : 2 pontsD: 1 point : E :0 points
A- up to 1.5 % errorB- Up to 2.5% errorC-Up to 3.0 % errorD-Upto 4.0 % errorE- above 4.0 %
10
Limit test A- All radicals correctB- 2 radicals correctC-1 radical correctD-correct format of recording onlyE-No radical correct and no report in format
5
43
44
WORK AND CREDIT DISTRIBUTION STATEMENT
Course Title
1st Sem 2nd Sem 3rd Sem 4th Sem 5th Sem 6th Sem Total Credit
Core Course : 50 Credits Language : 38Credits Complimentary : 24 credits Project : 4 credits Open Course :4 Credits
45
University of CalicutV th Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IModel Question Paper - I
Time 3 Hrs] Max Weightage -30I. answer all the questions. Each question has a weightage of ¼. Questions in this section will be multiple choice type:
1. Energy Balance is a) Chemical Balance b) Electronic balance c) Balance of energy at reactant and product side d) Balance of Enthalpy
2. A Flow Diagram is a) Diagram of Liquid Flow b) Diagram of Solid Flow c) Flow of water d) algorithm of the process presented as connected Block Diagrams
3. What is NASICON a) A Paint b) A Catalyst c) A Polymer d) Sodium Metal Oxide Semiconductor
4. What is the use of alumina a) as an adsorbent in chromatography b) As a Catalyst c) As a Surface active agent d) As a filler
5. What is the basic raw material for the manufacture of ceramic materials a) Clay b) Iron c) Alumina d) gypsum
6. What do you mean by the term composite a) A polymer b) A resin c) A catalyst d) A nano material 7. Calorific Value is related to a) Food b) Drug c) Thermochemistry d) Fuel
8. Strength of alkali in soap manufacture is measured in a) Beuam Scale b) Milli Litre c) Mole fraction d) Henry Scale
9. A Cream is a) A soap b) ointment c) Partially saponified and emulsified oil d)Detergent
10. An anti perspirant is a) Perfume b) Sweat controlling agent c)Sun tan Lotion d )Aantifungal
11. Basic raw material for manufacture of talcum powder is a) Talc b) Stearic Acid c) EDTA d) Perfume
46
12. Slip Means a) Spreading b) Masking c) Colouring d) Filling as small layer
II Answer all questions. Each question has a weightage 1:
13. Explain the terms Unit process, unit operation14. How can you explain a chemical reaction treated as a mass transfer operation15. What is a flow diagram ?16. Define calorific value of a fuel17. What is the difference between streamline flow and turbulent flow18. What micro composites ? how are they different from nano-composites19. What is meant by turbulent flow ?20. Explain how the size of paricles explained in cosmetic industry ?21. What is meant by USP ?
III Answer any five questions. Each has a weightage 222. What are ion selective electrodes ?23. Explain the importance and use of HPLC24. What do you mean by surface active agents ?What are their importance in detergent industry?25. How is a cream different from a soap ?26. Explain the action of anti perspirant ?27. How is shampoo manufactured ?28. Calculate the strength of caustic soda to equate 50 g. of coconut oil in soap manufacture?
IVAnswer any two questions. Each question has a weightage of 4
29. Give a brief idea of energy balance and material balance30. What are heat exchangers ? explain briefly the shell and plate types.31. Explain the principles and methods aerobic and anaerobic effluent treatment
Set1
47
University of CalicutV th Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IModel Question Paper - I
Time 3 Hrs] Max Weightage -30
I. answer all the questions. Each question has a weightage of ¼. Questions in this section will be multiple choice type:
1 Crystallisation is a) unit operation b) Unit process c) Unit reaction d) Unit cell
2. Streamline flow is a)Turbulent flow b) flow with same velocity c) flow with same velocity gradient d) distributed flow
3. Clay is used for making a) Refractory materials b) Catalysta c) silicates d) Molecular sieves
4. Blending means a) Mixing b) Casting c)rolling d) separating
5. PA means a) Polyaniline b) Polyalkene c) Polyacetyl group d) Polyamine
6. Mesh of filler means a) Quality of filler b) size of particle of filler c )Quantity of filler d) Property of filler
7. A soap is a) Detergent b) Sodium salt of fatty acid c) sodium salt of organic acid d) sodiumsalt of protein
8. In shaving soap a)Potassium Hydroxide is used b) Sodium Hydroxide is used c) Borax is used d) lithium hydroxide is used
48
9. Vanishing cream is made from a) Stearic acid and sodium hydroxide b) Stearic acid and potassium hydroxide c) Stearic acid and triethanol amine d) Stearic acid and borax
10. Aluminium chloro hydrate is a) Perfume b) Antifungal c) Anti perspirant d) Anti microbial
11. Silicones can be used as a) Lubricant b) Diluent c) Preservative d) Catalyst
12. A varnish is a)Opaque b) translucent c) Transparent d) Fluorescent
II Answer all questions. Each question has a weightage 1:
13. What are the common perfume fixers intoilet soap ?14. What is the action of antiperspirants ?15. What is the role of filler in cosmetic industry16. What are the qualities of good talcum powder ?17. What are the common preservatives used in food preparation18. What is a particle size analyzer? where does it find application19. Give an example of azo dye.Wha is its structure?20. Write two examples of ion selective electrode?21. Write an example for fluorescen brightening agent.Write the structure.
III Answer any five questions. Each has a weightage 222. Explain briefly the principles of flame emission spectroscopy.23. What are Mist Eliminators ?24. Write a note on waste recycling and its importance 25. Write a note on methods of dyeing26. Write a note on polymer processing which involve blending, moulding ,casting rolling and drawing27. What are vat dyes?Explain theprocess of vat deying28. Write a note on polymer processing technique.
IV Answer any two questions. Each question has a weightage of 429. What are molecular sieves ? explain its importance in drug manufacture 30. What do you mean by viscoelasticity of polymers ? How is Pf resin manufactured ?31. Explain the role of polymers in controlled drug delivery?.
Set2
49
University of CalicutVIth Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IIModel Question Paper - I
Time 3 Hrs] Max Weightage 30I. answer all the questions. Each question has a weightage of ¼. Questions in this section will be multiple choice type:
1.What do you mean by IP a) Indian penal code b) Indian pharmaceuticals c) Indian Penal act d) Indian Pharmacopoea
2. GMP means a) Good maintenance of premises b) Good manufacturing practices c) Good manufacturing potential d) Good maintenance procedure
3. SOP means a) Systematic office procedure b) symmetric office pattern c) Systematic online procedure d) synthetic oriental procedure
4. In taxonomy , identification of plant is a) Floral b) Root c) Fruit d) Stem cross section
5.Ash content is a term used in a) Crude drug evaluation b) Fnished product evaluation c) Formulation evaluation d) Assay
6. Moisture content is a characteristic test for a) crude drug b) finished product c) Cream d) Talcum powder
7. Filler should be a) Neutral b) acidic c) Basic d) Of a definite PH
8. Progesterone is a a) Flavone b) flavanoid c) Tannin d)Hormone
9. Excipient is a term associated with a) Cosmetics b) Drugs and formulations c) Paints d) dyes
10. Flavours are used in medicines for a) Increasing attractiveness b)Palatability c ) density increase d) Reducing cost
11. Chemical classification of plants is based on a) Flower b) Stomata c) functional Group d) Double bond
50
12. Biological classification of a drug is based on a) Biological activity of a drug b) Chemical reactions c) nature of flower d) taste
II Answer all questions. Each question has a weightage 1:
13. What do you mean by NF? How is it different from IP14. What is meant by parenteral route of administration?16. What do you mean by a glidant?17. Write the structure of ibuprofen.18. What is meant by stomatal index?19. What is the nature of acyclovir?20. What is an anti histamine?21. How is paracetamol synthesized ?
III Answer any five questions. Each has a weightage 2
22. What do you mean by asceptic condition ?23. Explain the significance of heparin 24. Write a note on NABL25. How is methyl dopa synthesized26. What do you mean by pyrogenic techniques? 27. Write note on glass sterilization.28. What do you mean by a flavanone?
IVAnswer any two questions. Each question has a weightage of 4
29. How is vinca alkaloid extracted? Explain the steps involved30. Wat is meant by pharmaceutical excipients ? Explain with example31. What are cardiovascular agents ? Give structure of two examples
[Set1
51
University of CalicutVIth Semester Degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IIModel Question Paper - I
Time 3 Hrs] Max Weightage 30
I. answer all the questions. Each question has a weightage of ¼. Questions in this section will be multiple choice type:
1. Syrup IP is a) Water solution b) Saline solution c) Glycerol d) Sugar solution
2. Parenteral route means a) Oral route b) External application c) Injectable d) Tablet
3. Talc is a)Glidant b) Surfactant c) Flavouring agent d) Bulking agent
4. Capsules are made from a) Soft gelati b) Gum c) Agar-agar d)Titanium oxide
5. Sorbitol is a a) Pharmaceutical base b) Cosmetic base c) Preservative d) antifungal
6. Eye preparation should contain a) An isotonic solution b) an isomer c) A monomer d)A colouring agent
7. Anti oxidants are a) Antacids b) free radical scavengers c) Chain initiators d) Chain terminators
8.Chloramphenicol is a) Anti bacterial b) Anti microbial c) Anti cold d) Antibiotic
9. Mefenamic acid is a) A febrifuge b) antiallergic c) Cardio vascular agent d) NSAID
10. Atenalol is an example for a) Alpha Blocker b) Beta Blocker c) Cardiotonic d) Antihistamine
11. Aciclovir is a) Anti bacterial b) Antifungal c) Anti cancer d) Antiviral
12. What is Librium
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a) Antibiotic b) Antacid c) Tranquiliser d) Anticancer
II Answer all questions. Each question has a weightage 1:
13. What is the role of viscosity builder in pharmaceutical industry14. Give example of an antiviral drug.15. What is the significance of loss of drying at 105°C ?16. What is the basic chemical reaction of synthesis of paracetamol ?17. What is the analytical method to determine assay of a drug with amino group18. What do you mean by extractive value?19. Define an anti histamine drug.Give an example?20. What is atenolol? What is its use?21. Write the structure of sulphamethoxasole?
III Answer any five questions. Each has a weightage 2
22. Write the structure of chloraphenamin maleate23. What is an antihistamine ? explainwith example24. Write a note on QSAR technique25. Comment on history and scope of pharmaceutical industry in India26. Write note on glass sterilization ?
27. What are fluorescent and brightening agents ? give examples28. How is diosgenin extracted ?
IVAnswer any two questions. Each question has a weightage of 4
29. Write the basic structure of phthalo cyanin dyes30. What are the basic chemical substances used in hair dye
31. Describe briefly on drug design and development
Set2
53
University of calicutVth Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IModel Question Paper - I
Time 3 Hrs] Max Weightage -30
Section AAnswer all questions. Each question has a weitage of ¼.Questions in this section will
be of multiple choice type.
I 1. Energy Balance is a ) Chemical Balance b) Electronic balance c) Balance of energy at reactant and product side d) Balance of Enthalpy
2. A Flow Diagram is a) Diagram of Liquid Flow b) Diagram of Solid Flow c) Flow of water. d) algorithm of the process presented as connected Block Diagrams
3. What is NASICON a) A Paint b) A Catalyst c) A Polymer d) Sodium Metal Oxide Semiconductor
4. What is the use of alumina a) as an adsorbent in chromatography b) As a Catalyst c) As a Surface active agent d) As a filler
5 . What is the basic raw material for the manufacture of ceramic materials a) Clay b) Iron c) Alumina d) gypsum
6. What do you mean by the term composite a) A polymer b) A resin c) A catalyst d) A nano material 7. Calorific Value is related to a) Food b) Drug c) Thermochemistry d) Fuel
8 Strength of alkali in soap manufacture is measured in a) Beuam Scale b) Milli Litre c) Mole fraction d) Henry Scale
9. A Cream is a) A soap b) ointment c) Partially saponified and emulsified oil d)Detergent
10. An anti perspirant is a) Perfume b) Sweat controlling agent c)Sun tan Lotion d )Aantifungal
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11. Basic raw material for manufacture of talcum powder is a) Talc b) Stearic Acid c) EDTA d) Perfume
12. Slip Means a) Spreading b) Masking c) Colouring d) Filling as small layer
[Weightage 1 2 X ¼ = 3
Section BAnswer all questions
13. Explain the terms Unit process, unit operation14. How can you explain a chemical reaction treated as a mass transfer operation15. What is a flow diagram ?16. Define calorific value of a fuel17. What is the difference between streamline flow and turbulent flow18. What micro composites ? how are they different from nano-composites19. Give an example of azo dye .What is its structure ?20. Give two examples of ion selective electrodes21. Write an example for fluorescent brightening agent.What is the structure?
[Weightage 1 X 9 = 9
Section CAnswer any 5 questions
22. What are4 mist eliminators ?23. Explain the importance and use of HPLC24. What do you mean by surface active agents What are their importance in detergent industry?25. How is a cream different from a soap ?26. Write a note on polymer processing techniques27. What are vat dyes? Explain the process of vat dyeing28. What are poly phosphazenes? How are they manufactured? [Weightage 2 X 5= 10
Section DAnswer any two questions
29 Give a brief idea of energy balance and material balance.30. What are heat exchangers ? explain briefly the shell and plate types.31. Explain the principles and methods aerobic and anaerobic effluent treatment
[Weightage 4X 2 =8Set1
55
University of CalicutVth Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IModel Question Paper - I
Time 3 Hrs] Max Weightage -30
Section AAnswer all questions
1 Crystallisation is a) unit operation b) Unit process c) Unit reaction d) Unit cell
2. Streamline flow is a) Turbulent flow b) flow with same velocity c) flow with same velocity gradient d) distributed flow
3. Clay is used for making a) Refractory materials b) Catalysta c) silicates d) Molecular sieves
4. Blending means a) Mixing b) Casting c)rolling d) separating
5. PA meansa) Polyaniline b) Polyalkene c) Polyacetyl group d) Polyamine
6. Mesh of filler means a) Quality of filler b) size of particle of filler c )Quantity of filler d) Property of filler
7. A soap is a) Detergent b) Sodium salt of fatty acid c) sodium salt of organic acid d) sodiumsalt of protein
8. In shaving soap a)Potassium Hydroxide is used b) Sodium Hydroxide is used c) Borax is used d)lithium hydroxide is used
9. Vanishing cream is made from a) Stearic acid and sodium hydroxide b) Stearic acid and potassium hydroxide c) Stearic acid and triethanol amine d) Stearic acid and borax
10. Aluminium chloro hydrate is a)Perfume b) Antifungal c) Anti perspirant d) Anti microbial
11. Silicones can be used as
56
a) Lubricant b) Diluent c) Preservative d) Catalyst
12. A varnish is a) Opaque b) translucent c) Transparent d) Fluorescent
[ Weightage 12 X ¼ =3
Section BAnswer all questions
13. What are the common perfume fixers intoilet soap ?14. What is the action of antiperspirants ?15. What is the role of filler in cosmetic industry16.What are the qualities of good talcum powder ?17.What are the common preservatives used in food preparation18.What is a particle size analyzer ? where does it find application19.What is vulcanized rubber?Why is it superior to natural rubber?20. Give two examples for colouring agents21.What is the difference between streamline flow and turbulent flow
[Weightage 1 x 9= 9
Section CAnswer any 5 questions
22. Explain briefly the principles of mass spectrometry.23. What are Mist Eliminators ?24. Write a note on waste recycling and its importance 25. Write a note on methods of dyeing26. What is a disintegrator?27. What are varnishes? How do they differ from paints28. Explain the basic principle of X-Ray fluorescence technique
[Weightage 2 X 5= 10Section D
Answer any two questions29. What are molecular sieves ? explain its importance in drug manufacture 30. What do you mean by viscoelasticity of polymers ? How is Pf resin manufactured?31 Explain the role of polymers in controlled drug delivery?
[Weightage 4 X 2 = 8
Set2
57
University of CalicutVIth Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IIModel Question Paper - I
Time 3 Hrs] Max Weightage -30
Section AAnswer all questions
1.What do you mean by IP a) Indian penal code b) Indian pharmaceuticals c) Indian Penal act d) Indian Pharmacopoea
2. GMP means a) Good maintenance of premises b) Good manufacturing practices c) Good manufacturing potential d) Good maintenance procedure
3. SOP means a) Systematic office procedure b) symmetric office pattern c) Systematic online procedure d) synthetic oriental procedure
4. In taxonomy , identification of plant is a) Floral b) Root c) Fruit d) Stem cross section
5. Ash content is a term used in a) Crude drug evaluation b) Fnished product evaluation c) Formulation evaluation d) Assay
6. Moisture content is a characteristic test for a) crude drug b) finished product c) Cream d) Talcum powder
7. Filler should be a) Neutral b) acidic c) Basic d) Of a definite PH
8. Progesterone is a a) Flavone b) flavanoid c) Tannin d)Hormone
9. Excipient is a term associated with a)Cosmetics b) Drugs and formulations c) Paints d) dyes
10. Flavours are used in medicines for a) Increasing attractiveness b)Palatability c ) density increase d) Reducing cost
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11. Chemical classification of plants is based on a) Flower b) Stomata c) functional Group d) Double bond
12. Biological classification of a drug is based on a) Biological activity of a drug b) Chemical reactions c) nature of flower d) taste
Weightage 12 X ¼ =3
Section BAnswer all questions
13. What do you mean by NF ? How is it different from IP14. What is meant by parenteral route of administration ?15. What is the disadvantage of taxonomical classification of plants ?16. What do you mean by a glidant ?17. Write structure of ibuprofen18. What is meant by stomatal index19. Gve twoexamples of an anti viral drug20. Write the structure of sulphamethoxasole21. Define anti histamine .Give one example
[Weightage 1 x 9= 9
Section CAnswer any 5 questions
22.What do you mean by asceptic condition ?23. Explain the significance of heparin 24. Write a note on NABL25. How is methyl dopa synthesized26. Comment on history and scope of Pharmaceutical Industry in India27. What do you mean by pyrogenic techniques? 28. Write a note onglass sterilisation
[weightage 2 X 4 = 8
Section DAnswer any two questions
29. How is vinca alkaloid extracted? Explain the steps involved30. Wat is meant by pharmaceutical excipients ? Explain with example31. What are cardiovascular agents ? Give structure of two examples.
[weightage 4 X 2 = 8Set1
59
VIth Semester degree ExaminationB. Sc. Industrial Chemistry Main
Core Paper Industrial Chemistry IIModel Question Paper - I
Time 3 Hrs] Max Weightage -30Section A
Answer all questions
1. Syrup IP is a) Water solution b) Saline solution c) Glycerol d) Sugar solution
2. Parenteral route means a) Oral route b) External application c) Injectable d) Tablet
3. Talc is a) Glidant b) Surfactant c) Flavouring agent d) Bulking agent
4. Capsules are made from a) Soft gelati b) Gum c) Agar-agar d)Titanium oxide
5. Sorbitol is a a) Pharmaceutical base b) Cosmetic base c) Preservative d) antifungal
6. Eye preparation should contain a) An isotonic solution b) an isomer c) A monomer d)A colouring agent
7.Anti oxidants are a) Antacids b) free radical scavengers c) Chain initiators d) Chain terminators
8. Chloramphenicol is a) Anti bacterial b) Anti microbial c) Anti cold d) Antibiotic
9. Mefenamic acid is a) febrifuge b) antiallergic c) Cardio vascular agent d) NSAID
10. Atenalol is an example for a) Alpha Blocker b) Beta Blocker c) Cardiotonic d) Antihistamine
11. Aciclovir is a) Anti bacterial b) Antifungal c) Anti cancer d) Antiviral
12. What is Librium a) Antibiotic b) Antacid c) Tranquiliser d) Anticancer [Weightage 12 X ¼ =3
60
Section BAnswer all questions
13. What is the role of viscosity builder in pharmaceutical industry14. Give example of an antiviral drug /15. What is the significance of loss of drying at 105 o C ?16. What is the basic chemical reaction of synthesis of paracetamol ?17. What is the analytical method to determine assay of a drug with amino group18. What do you mean by extractive value19. Write the biological importance of INH20. Name any two anti tubercular drug21. Write the structure of ibuprofen.
[Weightage 1 x 9 = 9
Section CAnswer any 5 questions
22. Write the structure of chloraphenamin maleate23. What is an antihistamine ? explainwith example24. Comment on history and scope of pharmaceutical industry in India25. How are plants classified?26. How is methyl dopa synthesized?27. Write on NABL28. Write briefly on cardio vascular drugs
[weightage 2 X 5= 10
Section DAnswer any two questions
29. Write the basic structure of phthalo cyanin dyes30. What are the basic chemical substances used in hair dye31. Describe briefly on drug design and developement
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