INFECTION AND IMMUNITYVOLUME 52 * JUNE 1986 * NUMBER 3

J. W. Shands, Jr., Editor in Chief (1989)University of Florida, Gainesville

Phillip J. Baker, Editor (1990)National Institute ofAllergy and

Infectious DiseasesBethesda, Md.Edwin H. Beachey, Editor (1988)VA Medical CenterMemphis, Tenn.

Peter F. Bonventre, Editor (1989) Arthur G. Johnson, Editor (1986)University of Cincinnati University of Minnesota, DuluthCincinnati, Ohio Qtpnhan R. Mprapnhnan Fditnr t

Roy Curtiss III, Editor (1990)Washington UniversitySt. Louis, Mo.

(1 Q9.Q

National Institute ofDental ResearchBethesda, Md.

Leonard C. Altman (1986)Michael A. Apicella (1988)Roland Arnold (1987)John B. Bartlett (1988)Joel B. Baseman (1988)Robert E. Baughn (1987)Gary K. Best (1988)Jenefer Blackwell (1988)Arnold S. Bleiweis (1987)William H. Bowen (1988)David E. Briles (1988)Robert R. Brubaker (1986)Gerald Byrne (1988)Bruce Chassy (1987)John 0. Cisar (1988)William B. Clark (1988)John Clements (1988)Don B. Clewell (1987)Myron S. Cohen (1987)R. John Collier (1987)Jorge H. Crosa (1988)Jim E. Cutler (1987)James B. Dale (1988)Judith E. Domer (1986)James L. Duncan (1988)Dennis Dwyer (1987)Roman Dziarski (1987)Robert A. Eisenberg (1987)Barry Eisenstein (1988)

Helen R. Whiteley,

EDITORIAL BOARDToby K. Eisenstein (1987)Peter Elsbach (1986)Stanley Falkow (1988)John R. Finerty (1987)Robert Fitzgerald (1986)James D. Folds (1988)Samuel B. Formal (1986)Peter Gemski (1988)Robert Genco (1988)Ronald J. Gibbons (1988)Emil Gotschlich (1988)Frank Griffin (1987)Richard Guerrant (1986)Thomas L. Hale (1987)Robert E. W. Hancock (1988)Edgar Hanna (1987)Eric J. Hansen (1986)Thomas P. Hatch (1988)David Hentges (1988)Randall K. Holmes (1986)Marcus A. Horwitz (1987)Dexter H. Howard (1988)Vincent J. Iacono (1988)Barbara Iglewski (1986)Richard E. Isaacson (1987)Howard M. Johnson (1988)Russell C. Johnson (1988)William Johnson (1988)Dennis L. Kasper (1988)

Chairman, Publications BoardLinda M. Illig, Managing Editor, Journals

F. Kierszenbaum (1987)Paul Kolenbrander (1986)Julius P. Kreier (1986)Maurice J. Lefford (1987)Thomas Lehner (1986)Stephen H. Leppla (1988)F. Y. Liew (1988)Francis L. Macrina (1988)John Mansfield (1988)Jerry R. McGhee (1988)Floyd C. McIntire (1988)Monte Meltzer (1986)Jiri Mestecky (1986)J. Gabriel Michael (1986)Henry W. Murray (1986)Carol A. Nacy (1987)Alison O'Brien (1988)Itzhak Ofek (1986)Andrew B. Onderdonk (1987)Monique Parant (1987)Shelley M. Payne (1988)Nathaniel F. Pierce (1986)Matthew Poliack (1986)Reuben Ramphal (1988)Richard R. Ranney (1988)Ruth Rappaport (1986)John B. Robbins (1986)Donald Robertson (1987)Burton Rosan (1986)

Kirk Jensen,

Catherine Saelinger (1987)Dwayne C. Savage (1987)Irving E. Salit (1986)Charles F. Schachtele (1988)Julius Schachter (1986)Gary K. Schoolnik (1987)June R. Scott (1987)Philip Scott (1988)Alan Sher (1987)Gerald D. Shockman (1986)W. A. Simpson (1988)Phillip D. Smith (1988)Ralph Snyderman (1988)Maggie So (1986)P. Frederick Sparling (1987)Barnet M. Sultzer (1988)Catharina Svanborg-Eden (1988)John L. Swanson (1987)Diane Taylor (1987)K. N. Timmis (1987)Ivo van de RUn (1987)Johannes van Houte (1988)Stefanie Vogel (1988)Peter A. Ward (1988)William P. Weidanz (1987)P. H. Williams (1987)Jerry A. Winkelstein (1987)Herbert H. Winkler (1986)Elizabeth J. Ziegler (1988)Wendell D. Zollinger (1988)

Director of PublicationsThomas M. Rogers, Production Editor

Infection and Immunity (ISSN 0019-9567), a publication of the American Society for Microbiology, 1913 I St., NW,Washington, DC 20006, is devoted to the advancement and dissemination offundamental knowledge concerning: (i) infectionscaused by pathogenic bacteria, fungi, and unicellular parasites; (ii) the ecology and epidemiology of pathogenic microbes; (iii)virulence factors, such as toxins and microbial surface structures; (iv) nonspecific factors in host resistance and susceptibilityto infection; and (v) immunology of microbial infection. Instructions to authors are published in the January issue each year;reprints are available from the editors and the Publications Department. Infection and Immunity is published monthly, and thetwelve numbers are divided into four volumes per year. The nonmember subscription price is $280 per year; single copies are$21. The member subscription price is $41 (foreign, $54 [surface rate]) per year; single copies are $7. Correspondence relatingto subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submittedmanuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW,Washington, DC 20006 (phone: 202 833-9680).Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after

publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues.Claims for issues missing because of failure to report an address change or for issues "missing from files" will not be allowed.Second class postage paid at Washington, DC 20006, and at additional mailing offices.POSTMASTER: Send address changes to Infection and Immunity, ASM, 1913 I St., NW, Washington, DC 20006.Made in the United States of America.Copyright C) 1986, American Society for Microbiology. a*:.d4Ikr. Alr& '1;t2All Rights Reserved.The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the ar-

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Author IndexAbraham, David, 742Alderete, John F., 736Anthony, Bascom F., 908Avigan, David, 756

Babcock, Lori, 803Barnes, David W., 714Barrett, Leah J., 702Baseman, Joel B., 736Bellanti, Joseph A., 853Blackburn, Evelyn, 650Bout, D., 823Braley-Mullen, Helen, 867Brennan, Michael J., 840Britigan, Bradley E., 657Brogden, Kim A., 644Burhop, Kenneth E., 905

Caldwell, J., 682Capron, A., 823Cavacini, Lisa A., 637Cerquetti, M. Cristina, 853Chaby, Richard, 777Chedid, Louis A., 725Chia, John K. S., 756Chiang, Yu-wei, 792Cho, Y. J., 828Cisar, John O., 840Clemons, Karl V., 763Cohen, Myron S., 657Concepcion, Nelydia F., 908Conlin, Christopher A., 676Cowell, James L., 695Cox, Charles D., 885Cutlip, Randall C., 644

David, Brien C., 707Deicher, Helmuth, 818de Jong, M. H., 897Deslee, D., 823Dosne, Anne M., 725Dubor, Frederic, 725

Edwards, Mark, 863Ekwall, Erik, 834Ellner, Jerrold J., 748Ensergueix, Danielle, 777

Fairchild, Robert L., 867Falkowski, Walter, 863Farrell, Jay P., 742Feldman, David, 763Fuquay, Janice I., 714

Ganz, Tomas, 902Gervais, Francine, 688Girard, Robert, 777Gmur, Rudolf, 768Goodrum, Kenneth J., 803Guerrant, Richard L., 702Guggenheim, Bernhard, 768

Hammarstrom, Lennart, 834Harada, Kazuhiro, 872Hess, C. B., 828Hooke, Anne Morris, 853Hrodek, Katerina, 768Hughes, Carrie A. Norton,914

Ikeda, Takako, 872Imoto, Masahiro, 872

Johnson, Priscilla T., 707

Kaeberle, Merlin L., 792Kamata, Yoichi, 786Kang, Jane H., 908Kasai, Nobuhiko, 872Kelly, Daryl J., 718Kim, Kwang Sik, 908King, Charles H., 748Klimpel, G. R., 828Klimpel, K. D., 828Kotani, Shozo, 872Kozaki, Shunji, 786Kraft, William G., 707Kusumoto, Shoichi, 872

Lachmann, Petra G., 818Lehmkuhl, Howard D., 644Lehner, T., 682Lehrer, Robert I., 902Lindberg, Alf A., 834Lior, Hermy, 702

Long, Carole A., 637Loo, Deryk T., 714Lopatin, Dennis E., 650Lutz, Frieder, 846

Manclark, Charles R., 695Marcelis, Jan H., 892Mehlert, A., 682Miller, Helen L., 803Mitsuyama, Masao, 730Morelec, Marie-Josephe, 777Morgan, Donna R., 707Morgan, Perri A., 664Mortensen, Richard F., 688Motley, Milwood A., 676

Nagai, Takafumi, 786Nakano, Hitoo, 730Neuhof, Heinz, 846Niemialtowski, Marek, 798Niesel, D. W., 828Nolte, Frederick S., 676Nomoto, Kikuo, 730

Ogasawara, Jun, 786Ogawa, Tomohiko, 872Okamura, Haruki, 872

Pearson, Richard D., 702Pennie, Ross A., 702Persson, Mats A. A., 834Pollack, Matthew, 756Proctor, Richard A., 905

Raetz, Christian R. H., 905Ramsay, Mary A., 671Rees, John C., 718Register, Karen B., 664Rogers, A. H., 897Rossi, Alida A., 812Roth, James A., 792Rubin, Lorry G., 911

Sakaguchi, Genji, 786Sandberg, Ann L., 840Sanford, Barbara A., 671Sano, Masatoshi, 730

Saxer, Ulrich P., 768Schaeffer, Anthony J., 863Schar, Gertrud, 763Seeger, Werner, 846Selsted, Michael E., 902Shiba, Tetsuo, 872Simpson, Lance L., 858Singh, Prati Pal, 688Skamene, Emil, 688Smith, C. I. Edvard, 834Sordelli, Daniel O., 853Spagnuolo, Philip J., 748Spitznagel, John K., 803Sriyosachati, Somporn, 885Steinbach, Suzanne, 756Sterner, Kay E., 867Stevens, David A., 763Stover, E. Price, 763Szklarek, Dorothy, 902

Takada, Haruhiko, 872Takahashi, Ichiro, 872Tamura, Toshihide, 872Tanaka, Shigenori, 872Targowski, Stanislaw P., 798Thomas, Wayne R., 812Thomas, D. Denee, 736Tsujimoto, Masachika, 872

Urisu, Atsuo, 695

van der Hoeven, J. S., 897Verhoef, Jan, 892Vreede, R. W., 892

Walmrath, Dieter, 846Warejcka, Debra J., 803Watanabe, Yoshitsugu, 730Weaver, James L., 803Weidanz, William P., 637Weiner, David J., 742Will, James A., 905Wyrick, Priscilla B., 664

Yoshimura, Hiroyuki, 872Yotis, William W., 914

Zilm, P. S., 897

AUTHOR INDEX

VOLUME 52

Abney, Tom O., 331Abraham, David, 742Ackermans, F., 408Ahmad, F., 631Albright, Elizabeth L., 499Alderete, John F., 70, 736Almagor, Miriam, 240Amako, Kazunobu, 236Amano, Atsuo, 421Anthony, Bascom F., 908Anthony, Ronald L., 36Arita, Michiko, 45Arnon, Ruth, 562Avigan, David, 756

Babcock, Lori, 803Bach, Marie-Anne, 303Balber, Andrew E., 223Baldini, Mary M., 334Barbour, Alan G., 549Barenkamp, Stephen J., 183,572

Barnes, David W., 714Barrett, John F., 101Barrett, Leah J., 702Baseman, Joel B., 736Baskerville, Arthur, 349Becker, Jeanne, 488Beesley, Julian, 344Bell, Clara, 519Bellanti, Joseph A., 853Berche, Patrick, 50Bertram, Timothy A., 285Best, Gary K., 331Bhakdi, Sucharit, 63Blackburn, Evelyn, 650Blanchard, D. Kay, 488Bortolussi, Robert, 493Bout, D., 823Braley-Mullen, Helen, 867Brennan, Michael J., 840Brettle, R. P., 631Britigan, Bradley E., 657Britt, Lorene A., 138Brogden, Kim A., 644Broster, Malcolm G., 356Burhop, Kenneth E., 905

Calder, M. A., 631Calder6n, Inds, 209Caldwell, J., 682Callahan, Lynn T., III, 56Canning, Peter C., 285Capron, A., 823Carman, J. Anthony, 356Carneiro, Celia Regina

Whitaker, 230Case, Steven E., 314Casey, S. G., 384Cassell, Gail H., 594Caugant, Dominique A., 213Cavacini, Lisa A., 637Cerny, Andreas, 12Cerquetti, M. Cristina, 853Chaby, Richard, 777Chamberlain, Constance, 538Chedid, Louis A., 725Chen-Woan, Melissa, 401Chensue, Stephen W., 341Chia, John K. S., 756

Chiang, Yu-wei, 792Cho, Y. J., 828Cisar, John O., 840Clark-Curtiss, Josephine E.,

101Clemons, Karl V., 763Cluzel, Roger, 468Cohen, L., 555Cohen, Myron S., 657Cohen, Paul S., 18Concepcion, Nelydia F., 908Conlin, Christopher A., 676Cowell, James L., 695Cox, Charles D., 263, 885Cox, Rebecca A., 138Cromartie, W. J., 390Crosa, Jorge H., 192Cross, Alan S., 617Croughan, M. J., 631Cruz, Nancy, 293Cryz, S. J., Jr., 161Cunningham, Thomas M., 586Curtiss, Roy, III, 101Cutlip, Randall C., 644

Danielsson, D., 529Darfeuille-Michaud, Arlette,468

Davey, Michael P., 341David, Brien C., 707Davis, Jerry K., 594de Chastellier, Chantal, 252Deicher, Helmuth, 818de Jong, Marten, 175de Jong, M. H., 897Deslee, D., 823Devine, Dana V., 223Dosne, Anne M., 725Dougan, Gordon, 344Dowsett, A. Barry, 349Dubor, Frederic, 725Dyer, D., 529

Edwards, Mark, 863Ehrenfreund, Cindy, 56Eisemann, Christine S., 326Eisenstein, Toby K., 504Ekwall, Erik, 834Ellner, Jerrold J., 748Ellwood, Derek C., 349Ensergueix, Danielle, 777Esser, Ronald E., 390, 459Evenberg, Dolf, 175Ezzell, J. W., Jr., 454

Fairchild, Edward J., II, 613Fairchild, Robert L., 867Falk, Ronald J., 223Falkowski, Walter, 863Fanning, Mary M., 534Farrell, Jay P., 742Faruki, H., 529Faulkner, Gary, 493Fehniger, Thomas E., 579,

586Feldman, David, 763Ferretti, Joseph J., 144Finkelstein, Richard A., 562Finlay-Jones, John J., 245,

633,

Fischetti, Vincent A., 609Fleming, Tony J., 600Flynn, Patricia M., 26Forestier, Christiane, 468Frank, R. M., 408Franzon, Vicki L., 279Frehel, Claude, 252Friedman, Herman, 488Frik, Jan, 175Fujikawa, Hiroshi, 134Fukui, Komei, 628Fuquay, Janice I., 714Furer, E., 161Furugouri, Kou, 623Futrovsky, Susan L., 617

Gaillard, Jean Louis, 50Gammon, Maureen T., 56Ganz, Tomas, 902Germanier, R., 161Gervais, Francine, 688Gibbons, Ronald J., 378, 555Gilon, Chaim, 240Girard, Robert, 777Gmur, Rudolf, 768Goldhar, J., 205Goodrum, Kenneth J., 803Goodsaid, Federico, 309Granoff, Dan M., 183Grant, Christopher C. R., 538Gray, Beulah H., 90Guerrant, Richard L., 323,

702Guggenheim, Bernhard, 768

Hackbarth, C. J., 484Hackstadt, Ted, 337Hahn, Helmut, 488Hammarstrom, Lennart, 834Hamood, Abdul N., 476Hanioka, Takashi, 421Harada, Kazuhiro, 872Harboe, Morten, 293Hart, Prue H., 245Hay, D. I., 555Hayashi, Katsutoshi, 397Hayashi, Seiji, 128Hayes, Edward, 56Hayes, Stanley F., 549Hedlund, K. W., 454Heiland, Ramona A., 549Hengartner, Hans, 12Hess, C. B., 828Heyworth, Martin F., 568Hildner, William K., 26Hill, Joseph O., 364Holder, Ian Alan, 200Holland, Ian Barry, 63Hollingshead, Susan K., 609Holt, Peter S., 9Honda, Takeshi, 45, 319Hooke, Anne Morris, 853Horiguchi, Yasuhiko, 31Hormaeche, Carlos, 344Hosoe, Shigeto, 128Hovde, Carolyn J., 90Hrodek, Katerina, 768Huesca, Mario, 309Hughes, Carrie A. Norton,914

Hugin, Ambros W., 12Hui, George S. N., 314Huq, I. M., 323

Igarashi, Hideo, 134Ikeda, Takako, 872Imoto, Masahiro, 872Inoshita, Eiji, 421Ishikawa, Yoshiharu, 623Issekutz, Andrew, 493Ivins, B. E., 454

Jackson, Jesse, 56Jacob, Chaim O., 562Jacobs, William R., 101Jamet, Pierre, 303Janusz, Michael J., 459Jarboe, Daniel L., 326Jemski, J., 454Jerrells, Thomas R., 326Jewell, Marvin, 56Johnson, Priscilla T., 707Joly, Bernard, 468

Kaeberle, Merlin L., 792Kahane, Itzhak, 240Kamata, Yohichi, 31Kamata, Yoichi, 786Kan, Siu-Chow, 314Kang, Jane H., 908Kaper, James B., 334Kapperud, Georg, 85Karpas, Arthur, 519Kasai, Nobuhiko, 872Kasmala, Lorraine, 70Kato, Hirohisa, 628Kaufman, Bennett M., 617Kawase, Ichiro, 128Kazura, James W., 534Kelly, Daryl J., 718Kilian, Mogens, 171Killar, Loran M., 504Kim, Kwang Sik, 908King, Charles H., 748Kirkland, Jerry J., 331Kishimoto, Susumu, 128Klein, J. P., 408Klein, Thomas W., 488Klimpel, G. R., 828Klimpel, K. D., 828Kling, J. Malcolm, 331Knudson, Gregory B., 509Koellreutter, Brigitte, 428Korhonen, Timo K., 213Kotani, Hitoshi, 437Kotani, Shozo, 872Kozaki, Shunji, 31, 786Kozel, Thomas R., 1Kraft, William G., 707Kramer, Kenton J., 314Kume, Katsumi, 370Kunkel, Steven L., 341Kuramitsu, Howard K., 166Kusumoto, Shoichi, 872

Lachmann, Petra G., 818Lang, Thierry, 252Lassen, J0rgen, 85Laux, David C., 18Law, Edward J., 200

i

ii AUTHOR INDEX

Lee, David A., 397Lehmkuhl, Howard D., 644Lehner, T., 682Lehrer, Robert I., 902Leppla, S. H., 454Liew, Foo Y., 344Lindberg, Alf A., 834Lior, Hermy, 702Little, Stephen F., 509Lobos, Sergio R., 209Long, Carole A., 637Loo, Deryk T., 714Lopatin, Dennis E., 650Lopes, Josd Daniel, 230Lopez, Angel F., 245Lovett, Michael A., 579, 586Lucken, Roger, 76Lugtenberg, Ben, 175Lutz, Frieder, 846

Maclntyre, Sheila, 76Mackert, Paul W., 26Mackman, Nigel, 63Madonna, Gary S., 6Manchee, Richard J., 356Marclark, Charles R., 695Manning, Paul A., 279Mansa, Bendt, 171Manyak, Christine L., 56Marcelis, Jan H., 892Marsh, Philip D., 349Maskell, Duncan, 344Masuno, Tomiya, 128McCabe, Robert E., 151McDermid, Ann S., 349McDonald, Peter J., 245, 633McGarrity, Gerald J., 437McGregor, Douglas D., 401McKee, Ailsa S., 349McLeod, D. T., 631McSweegan, Edward F., 18Mehlert, A., 682Melling, Jack, 356Miller, Helen L., 803Miller, James N., 579, 586Miner, Karen M., 56Misfeldt, Michael L., 96Mitsuyama, Masao, 236, 730Miwatani, Toshio, 45, 319Miyata, Yasuhiko, 623Momotani, Eiichi, 623Montafio, Luis F., 309Mora, Guido C., 209Morelec, Marie-Josephe, 777Morgan, Donna R., 707Morgan, Perri A., 664Morris, Randal E., 445Mortensen, Richard F., 688Moseley, Steve L., 323Motley, Milwood A., 676Munson, Robert S., Jr., 414Musser, James M., 183

Nagai, Sadamu, 293Nagai, Takafumi, 786Nakai, Toyotsugu, 370Nakano, Hitoo, 730Nataro, James P., 334Neely, Alice N., 200Neeser, Jean-Richard, 428Neuhof, Heinz, 846Nicaud, Jean-Marc, 63

Niemialtowski, Marek, 798Niesel, D. W., 828Nikoloutsopoulos, Antonios,

245Nolte, Frederick S., 676Nomoto, Kikuo, 156, 236, 730Nomoto, Koji, 156, 236Noonan, Susan K., 401Norgard, Michael V., 110Nulsen, Mary F., 633

Obara, Yoshiaki, 623Ofek, I., 205Ogasawara, Jun, 786Ogawa, Tomohiko, 872Ogier, J., 408Ogura, Takeshi, 128Ohara, Reiko, 236Okamura, Haruki, 872Olds, G. Richard, 513Ota, Fusao, 628Owen, Peter, 76

Palmer, Kevin L., 314Palomino, Carmen, 209Parke, James C., Jr., 519Parker, Charlotte D., 476Parra, Cecilia, 309Paster, Bruce J., 378Patarroyo, Manuel E., 293Pattison, Patricia E., 213Peacock, Marius G., 120Pearson, Richard D., 702Peavy, Duane L., 613Pennie, Ross A., 702Persson, Mats A. A., 834Peterson, Jon E., 6Pfrommer, Gail S. T., 1Pollack, Matthew, 756Proctor, Richard A., 905

Quie, Paul G., 397

Radolf, Justin D., 579, 586Raetz, Christian R. H., 905Ramirez, Clara, 293Ramsay, Mary A., 671Rapp, Vicki J., 414Rastogi, Nalin, 252Ray6n, Ignacio, 309Reed, William P., 499Rees, John C., 718Register, Karen B., 664Rehg, Jerold E., 26Remick, Daniel G., 341Remington, Jack S., 151Ribi, Edgar E., 6Ridel, Pierre-Richard, 303Ristroph, J. D., 454Robbins, John B., 519Robin, Yves, 303Rodloff, Arne C., 488Rodrfguez, Luis H., 209Rogers, A. H., 897Rojas, Hdctor A., 209Rosenthal, Raoul S., 600Ross, Richard F., 414Rossi, Alida A., 812Roth, James A., 285, 792Rubin, Lorry G., 911Russo, J., 620

Sacci, John B., 36Sadoff, J. C., 161Sadoff, Jerald C., 617Saelinger, Catharine B., 445Sakaguchi, Genji, 31, 786Sakatani, Mitsunori, 128Samejima, Yuji, 370Sandberg, Ann L., 840Sande, M. A., 484Sanford, Barbara A., 671Sano, Masatoshi, 730Sansonetti, Philippe, 50Sato, Setsuko, 166Saxer, Ulrich P., 768Schaeffer, Anthony J., 863Schar, Gertrud, 763Schiffman, Gerald, 519Schlesselman, James J., 519Schneerson, Rachel, 519Scholler, M., 408Schrumpf, Merry E., 549Schwab, John H., 390, 459Scott, David F., 331Scott, June R., 609Seeger, Werner, 846Selander, Robert K., 183, 213Sellwood, Richard, 344Selsted, Michael E., 902Shafer, W. M., 384Shenep, Jerry L., 26Shiba, Tetsuo, 872Shiloach, Joseph, 519Shimizu, Takako, 156Shizukuishi, Satoshi, 421Sidberry, Hazel F., 617Siddiqui, Wasim A., 314Sigal, Nolan H., 56Silver, Richard P., 192Silverblatt, Fredric J., 579Simpson, Lance L., 858Singh, Prati Pal, 688Skamene, Emil, 688Small, P. M., 484Smith, C. I. Edvard, 834Snellgrove, Richard L., 26Snider, Denis P., 271Sordelli, Daniel O., 853Spagnuolo, Philip J., 748Sparling, P. F., 529Spencer, Lyn K., 245Spitznagel, J. K., 384, 803Sriyosachati, Somporn, 885Stavitsky, Abram B., 513Steinbach, Suzanne, 756Sterner, Kay E., 867Stevens, David A., 763Stewart, Scott T., 120Stimpson, Stephen A., 390Stokes, Dennis C., 26Storm, Paul, 175Stover, E. Price, 763Sublett, Richard D., 476Sugimoto, Chihiro, 370Suprun-Brown, Leora, 70Sutton, Ann, 519Swancutt, Mark A., 110Sweeney, Kathy, 344Szklarek, Dorothy, 902

Takada, Haruhiko, 872Takahashi, Ichiro, 872Takeda, Tae, 45

Tam, Leslie Q., 314Tamagawa, Hiroo, 421Tamura, Hiroshi, 134Tamura, Toshihide, 872Tanaka, Shigenori, 134, 872Targowski, Stanislaw P., 798Tauber, M. G., 484Tessier, Sandra L., 549Thomas, D. Denee, 736Thomas, Wayne R., 812Tiemens, Karen M., 323Torres, Martha Lucia, 293Tsujimoto, Masachika, 872Tsunemitsu, Akira, 421Turnbull, Peter C. B., 356Twehous, Debra A., 110

Uemura, Takashi, 31Underdown, Brian J., 271Urisu, Atsuo, 695Usami, Hiroyuki, 134

Vadas, Mathew A., 245Vaisanen-Rhen, Vuokko, 213Valvano, Miguel A., 192van Boxtel, Ria, 175van der Hoeven, J. S., 897van Houte, J., 620Vasil, Michael L., 538Verhoef, Jan, 892Vogel, Stefanie N., 6Vreede, R. W., 892

Wachsmann, D., 408Wadolkowski, Elizabeth A.,

18Walfield, Alan M., 586Walker, David H., 120Wallsmith, Dirk E., 600Walmrath, Dieter, 846Wang, Zhen, 519Warejcka, Debra J., 803Watanabe, Yoshitsugu, 730Weaver, James L., 803Weeks, Claudia R., 144Weidanz, William P., 637Weikel, Cynthia S., 323Weiner, David J., 742Will, James A., 905Williams, Elaine, 56Williams, Jim C., 120Williams, Kristina M., 36Williams, Peter H., 213Williams, Taffy J., 18Williamson, Jo S. P., 594Willms, Kaethe, 309Wrann, Michael, 12Wuersch, Pierre, 428Wyrick, Priscilla B., 664

Yagawa, Katsuro, 628Yamaga, Karen M., 314Yamamura, Yuichi, 128Yatziv, Shaul, 240Yoh, Myonsun, 319Yokokura, Teruo, 156, 236Yoshimura, Hiroyu4i, 872Yoshino, Tomoo, 623Yotis, William W., 914

Zilberberg, A., 205Zilm, P. S., 897Zinkernagel, Rolf M., 12Zweerink, Hans, 56

INFECT. IMMUN.

SUBJECT INDEXVOLUME 52

Abscess formationnonimmune mice, 633T lymphocytes, 633

Actinobacillus actinomycetemcomitansperiodontitis, 768systemic host response, 768

Actinomyces naeslundiiadherence, 840glycoproteins, 840lectins, 840

Active inflammationinterleukins, 341tuberculosis, 341

Adherenceadhesive factor, 468A. naeslundii, 840antigens, 344aromatic hydrocarbons, 863B. pertussis, 695E. coli, 205, 334, 344, 428, 468, 863enterotoxins, 205epithelial cells, 863fibronectin, 736glycoproteins, 840hemagglutinin, 695HEp-2 cells, 334infant mouse model, 205inhibition, 863intestinal colonization, 205lectins, 840T. pallidum, 736type 1 pili, 428WiDr cells, 695

Adhesinsdirect adhesin overlay, 671S. aureus, 671staphylococcal membrane receptors,

671Aerobactin transport systemchromosomes, 192E. coli, 192hemolysin production, 192iron metabolism, 192plasmids, 192

Aminopyridinesbotulism, 858C. botulinum, 858toxins, 858

AnthraxB. anthracis, 509vaccines

live spore, 509protective antigen, 509

Antibodiesanthrax toxin, 356antigens, 356capsular polysaccharide-tetanus toxid

conjugates, 519carbohydrate-protein conjugate, 408complement, 892E. coli, 892G. muris, 271H. influenzae, 519, 572lethal factor components, 356liposomes, 408murine antibody response, 271opsonins, 892otitis media, 572parasites, 271porin antigens, 209protective immunity, 356

responsessaliva, 408serum, 408

rough mutants, 892Salmonella spp., 892S. mutans, 408S. typhi, 209typhoid infection, 209

Antibody-dependent cytotoxicityF. nucleatum, 650sensitization, 650

Antigenic variationN. gonorrhoeae, 529outer membrane proteins, 529

Antigensadherence determinant, 344anthrax toxin, 356antibodies, 356antibody binding, 579B. anthracis, 356binding activity, 171caries prevention, 682C. botulinum, 786C. burnetii, 337C. immitis, 138E. coli, 344, 586E. rhusiopathiae, 818exoantigen

characterization, 138isolation, 138

Faba, fragments, 171gingival immunization, 682immunoglobulins, 171immunoglobulin subclass patterns, 834lethal factor components, 356lipopolysaccharides, 337monoclonal antibodies, 230outer membrane, 586P. aeruginosa vaccine PEV, 76porins, 209protection, 76R. conorii, 326recombinant antigen 4D, 579R. rickettsii, 120Salmonella spp., 834S. flexneri, 834S. mansoni, 230smooth lipopolysaccharide, 76S. mutans, 682S. mutans polysaccharide, 628striucture, 786S. typhi, 209surface antigenic components

characterizatior, 818solubilization, 818

T-cell hybridomas, 326toxins, 786T. pallidum, 579, 586typhoid infection, 209variation, 337

Aotus monkey immunitymonoclonal antibodies, 314P. falciparum, 314

Aromatic hydrocarbonsE. coli adherence, 863epithelial cells, 863

Arthritisantigens, 818bacterial cell wall degradation, 459E. rhusiopathiae, 818mutanolysin, 459

Arthropathic activityN. gonorrhoeae

disseminated disease, 600peptidoglycan fragments, 600

Atrophic rhinitiscell surface proteins, 175P. multocida, 175

Attachmentpellicle receptors, 555S. mutans, 555S. sobrinus, 555

Bacillus anthracisanthrax toxin, 356antigens, 356immunization studies, 454lethal factor components, 356plasmids, 454protective immunity, 356toxins, 454vaccines, 509

Bacterial clearanceendotoxin liberation, 26methylprednisolone, 26

Bacterial competitionneutrophils, 657oxygen consumption, 657

Bacterial growth rateseffect of body temperature, 484meningitis, 484S. pneumoniae, 484

Bacteriophage T12S. pyogenes, 144type A exotoxin gene, 144

Bacteroides fragilismacrophages, 488phagocytosis, 488

Bacteroides gingivalisexohemagglutinin

characterization, 421isolation, 421

hemin, 349periodontitis, 768physiology, 349systemic host response, 768virulence, 349

Bacteroides intermediusperiodontitis, 768systemic host response, 768

BindingC. neoformnans, 1complement, 1iC3b, 1S. aureus, 714serum spreading factor, 714yeast, 1

Body temperaturebacterial growth rates, 484meningitis, 484S. pneumoniae, 484

Bordetella bronchisepticadermonecrotic toXin, 370

Bordetella pertussisadherence, 695hemagglutinin, 695WiDr cells, 695

Borrelia spp.epitopes, 549monoclonal antibodies, 549

Botulismaminopyridines, 858

iii

iv SUBJECT INDEX

C. botulinum, 858toxins, 858

Branhamella catarrhalisimmunoglobulins, 631protease production, 631

Brucella abortusneutrophils, 285preferential inhibition, 285primary granule release, 285

Brugia malayi"C. parvum," 534macrophages, 534M. bovis, 534microfilarial cytotoxicity, 534P. acnes, 534

Burn woundsC. albicans, 200lowered resistance, 200P. aeruginosa, 200

Campylobacter concisuschemotactic response, 378formate, 378gingival colonization, 378

Campylobacterjejuniserological characterization, 702susceptibility, 702

Candida albicansburn wounds, 200enhanced susceptibility to, 200P. aeruginosa, 200proteolytic qnzymes, 200rabbit granulocyte peptides, 902synergistic activity, 902

Capsular polysaccharide-tetanus toxoidconjugatesH. influenzae, 519serum antibodies, 519

Cariesantigens, 682caries prevention, 682oral microorganisms

characterization, 897growth parameters, 897

S. mutans, 682Cell surface proteins

atrophic rhinitis, 175characterization, 175P. multocida, 175

Cell surface receptorsintracellular killing, 245peritoneal exudate neutrophils, 245P. mirabilis, 245

Cell wallscomplement fixation, 803degradation, 390, 459group A and D streptococci, 390lysozyme, 803mutanolysin, 459Streptococcus spp., 803

Chemiluminescent responseH. ihfluenzae, 397polymorphonuclear leukocytes, 397S. pneumoniae, 397

Chemotaxinsneutrophil-mediated killing, 748opsonins, 748S. mansoni, 748

ChemotaxisChlamydia spp., 664polymorphonuclear leukocytes, 664

C3H/HeN miceacquired immunity, 128

N. rubra cell wall skeleton, 128Chlamydia spp.

chemotaxis, 664polymorphonuclear leukocytes, 664

CloningDNA coding, 812E. coli, 279hemagglutinin gene, 279H. influenzae type b, 812outer membrane proteins, 812V. cholerae, 279

Clostridium botulinumaminopyridines, 858antigens, 786botulism, 858monoclonal antibodies, 786toxins, 786, 858

Clostridium perfringensenterotoxins, 31monoclonal antibodies, 31

Coccidioides immitisexoantigen

characterization, 138isolation, 138

Colimycinendothelial cells, 725lipopolysaccharides, 725plasminogen antiactivator, 725polymyxin B, 725

Colony-stimulating factorC3H/HeN mice, 128enhanced production, 128N. rubra cell wall skeleton, 128

Complementactivation, 1alternative pathway regulation, 223antibodies, 892antimicrobial activity, 853cells walls, 803C. neoformans, 1E. coli, 892fixation, 803iC3b binding, 1lungs, 853lysozyme, 803opsonins, 892P. aeruginosa, 853rough mutants, 892Salmonella spp., 892Streptococcus spp., 803T. brucei subsp. gambiense, 223T. pallidum

antibody-binding resistance, 579recombinant antigen 4D, 579

yeast, 1Complexing

lipopolysaccharides, 644lung surfactant, 644

Coxiella burnetiiantigens, 337lipopolysaccharides, 337

Cryptococcus neoformanscomplement activation, 1iC3b binding, 1

Cutaneous infectionmouse model, 707Staphylococcus spp., 707

Cyclosporin Aantibacterial activity, 823immunity, 12L. monocytogenes, 12S. mansoni, 823

Cytotoxicity

antibody dependence, 650F. nucleatum, 650

Delayed-type hypersensitivityimmunity, 504S. typhimurium, 504

Dermonecrotic toxinB. bronchiseptica, 370characterization, 370

DiarrheaE. coli; 323STb enterotoxin, 323

Dipetalonema viteaeimmune response

cellular, 742humoral, 742

jirds, 742

Endotoxemialipid A, 905protection, 905

Endotoxinsactivities, 872bacterial clearance, 26clearance, 134early-phase tolerance, 6E. coli, 6, 56, 613E. coli-induced sepsis, 26liberation, 26lipid A, 6lipid peroxidation, 613methylprednisolonte, 26monoclonal antibodies, 56Salmonella-type lipid A, 872S. 'aureus, 134S. typhimurium, 6toxic shock syndrome toxin-1, 134

EnteritisC. jejuni

serological characterization, 702susceptibility, 702

Enterotoxinsadhesive factor, 468cholera toxin peptides, 562C. perfringens, 31diarrheal illness, 323E. coli, 323, 468, 562monoclonal antibodies, 31resistance to, 562STb, 323V. cholerae

characterization, 45purification, 45

Enzymesburn wounds, 200C. albicans, 200P. aeruginosa, 200proteolytic enzymes, 200

Epithelial cellsadherence, 840, 863A. naeslundii, 840aromatic hydrocarbons, 863E. coli, 863interferons, 828invasion, 828plant lectins, 840Shigella spp., 828

EpitopesBorrelia spp., 549flagellar epitope, 549monoclonal antibodies, 549

Erysipelothrix rhusiopathiaesurface antigenic components

INFECT. IMMUN.

SUBJECT INDEX v

characterization, 818solubilization, 818

Escherichia coliadherence, 205, 334, 428, 468, 863adherence antigen determinant, 344adhesive factor, 468aerobactin transport system, 192antibodies, 892antigens, 586aromatic hydrocarbons, 863cholera toxin peptides, 562clonal structure, 213complement, 892diarrheal illness, 323endotoxins, 56, 613enterotoxins, 205, 468, 562epithelial cells, 863genetic characterization, 213, 279glycopeptides, 428hemagglutinin gene, 279hemolysins, 63, 192HEp-2 cells, 334infant mouse model, 205intestinal colonization, 205iron metabolism, 192lipopolysaccharides, 617membrane damage, 63meningitis, 213monoclonal antibodies, 56, 110, 617mouse small intestine, 18mucosal receptors, 18neonatal septicemia, 213opsonins, 617, 892outer membrane, 586recombinant DNA-derived immunogen,

110rough mutants, 892STh enterotoxin, 323T. pallidum, 110, 586type 1 pili, 428V. cholerae, 279

Exoantigenscharacterization, 138C. immitis, 138isolation, 138

ExohemagglutininB. gingivalis, 421characterization, 421isolation, 421

Exotoxin Aimmune response suppression, 96P. aeruginosa, 96

Exotoxin A geneP. aeruginosa, 538virulence, 538

Exotoxinsfibroblasts, 445Pseudomonas exotoxin A, 445

Fab,, fragmentsantigen-binding activity, 171immunoglobulin Al protease, 171

Ferritinbovine paratuberculosis, 623granulomas, 623

Fibroblastsglutathione redox cycle, 240M. pneumoniae, 240vitamin E, 240

Fibronectinattachment, 736extracellular matrix, 736T. pallidum, 736

Filamentous hemagglutininadherence, 695B. pertussis, 695

FimbriaeE. coli, 468nonfimbrial adhesive factor, 468

FlagellaBorrelia-specific antibodies, 549epitopes, 549

FlagellinS. typhi, 209typhoid infection, 209

Flow cytometric analysisL. mexicana subsp. mexicana

binding, 36uptake, 36

monoclonal antibodies, 36peritoneal macrophages, 36promastigotes, 36

Fluorideplaque, 914T. denticola, 914

FormateC. concisus, 378chemotactic response, 378gingival colonization, 378

Fructosyltransferase genecharacterization, 166isolation, 166S. mutans, 166

Fusion inhibitionmacrophages, 252M. avium, 252phagosomes, 252

Fusobacterium nucleatumantibody-dependent cytotoxicity, 650sensitization, 650

Gamma radiationhost defenses, 718R. tsutsugamushi, 718scrub typhus, 718

Genetic characterizationcloning, 812E. coli, 213, 279, 334exotoxin A gene, 538fructosyltransferase gene

characterization, 166isolation, 166

group A streptococci, 609hemagglutinin gene, 279HEp-2 adherence, 334H. influenzae, 183, 812meningitis, 213M protein, 609neonatal septicemia, 213N. gonorrhoeae, 529outer membrane proteins, 529, 812P. aeruginosa, 538penB locus, 529S. mutans, 166S. pyogenes bacteriophage T12, 144type A exotoxin gene, 144V. cholerae, 279virulence, 538

Giardia murisimmunoglobulins, 271, 568mouse intestines, 568murine antibody response, 271trophozoites, 568

Gingival colonizationC. concisus, 378formate, 378

Gingival immunizationantigens, 682caries prevention, 682S. mutans, 682

Glutathione redox cyclefibroblasts, 240M. pneumoniae, 240protective effects, 240vitamin E, 240

Glycopeptidesadherence, 428E. coli, 428type 1 pili, 428

Glycoprotein immunogenmonoclonal antibodies, 70T. vaginalis, 70

Glycoproteinsadherence, 840A. naeslundii, 840plant lectins, 840

Granulocytesantimicrobial activity, 384N. gonorrhoeae, 384pyocin, 384

Granulomasinflammation

modulation, 513S. japonicum, 513

iron metabolism, 623M. paratuberculosis, 623

Group A streptococcigenetic characterization, 609M protein genes, 609

Group B streptococciantimicrobial activity, 908immunoglobulins, 908

Growth parametersoral microorganisms, 897plaque, 897

Haemophilus influenzaeantibodies, 519, 572capsular polysaccharide-tetanus toxoid

conjugates, 519genetic characterization, 183nontypable, 183otitis media, 572polymorphonuclear leukocytes, 397serological characterization, 572S. pneumoniae, 397

Haemophilus influenzae type bcloning, 812genetic characterization, 812multiplication rates

in vitro, 911in vivo, 911

outer membrane proteins, 812Haemophilus pleuropneumoniae

outer membrane protein, 414"Haemophilus somnus"

neutrophil suppression, 792polymorphonuclear leukocytes, 792

Hemagglutininadherence, 695B. gingivalis, 421B. pertussis, 695E. coli, 279exohemagglutinin, 421genetic characterization, 279V. cholerae, 279WiDr cells, 695

Hematopoietic responseenhancement, 156

VOL. 52, 1986

vi SUBJECT INDEX

L. casei, 156HeminB. gingivalis

physiology, 349virulence, 349

Hemolysinsaerobactin, 192cell damage, 63characterization, 319E. coli, 63, 192iron metabolism, 192L. monocytogenes, 50production, 192purification, 319transmembrane pore generation, 63transposon mutagenesis, 50V. cholerae, 319virulence, 50V. parahaemolyticus, 319

Hepatic clearanceopsonins, 499S. pneumoniae, 499

HEp-2 cellsadherence, 334E. coli, 334serotypic characterization, 85Y. enterocolitica, 85

Hormonesprogesterone, 763S. aureus, 331T. mentagrophytes, 763toxic shock syndrome, 331

Host defensehuman sera, 493L. monocytogenes, 493opsonins, 493

Humoral immune responseRocky mountain spotted fever, 120R. rickettsii, 120

Hybridomascharacterization, 326production, 326R. conorii, 326T cells, 326

Immune responseP. aeruginosa exotoxin A, 96suppression, 96

ImmunogensE. coli, 110monoclonal antibodies, 70T. pallidum, 110T. vaginalis, 70

Immunoglobulinsantigen binding, 171antimicrobial activity, 908B. catarrhalis, 631capsular polysaccharides, 867Faba, fragments, 171G. muris trophozoites, 568group B streptococci, 908IgA, 834IgG, 834IgM, 867lipopolysaccharides, 834mouse intestines, 568proteases

IgAl, 171IgGA1, 631

Salmonella antigens, 834S. flexneri, 834vaccines, 867

Infant mouse model

E. coliadherence, 205colonization, 205

enterotoxins, 205Interferons

epithelial cell invasion, 828natural IFN, 828recombinant IFN, 828Shigella spp., 828

Interleukinsactive inflammation, 341IL-1

release, 303, 341leprosy, 303macrophages, 303tuberculosis, 341

IntestinesE. coli

adherence, 205colonization, 205

G. muris trophozoites, 568immunoglobulins, 568infant mouse model, 205

Iron metabolismacquisition, 885aerobactin transport systemchromosome mediated, 192plasmid mediated, 192

E. coli, 192ferritin, 623granulomas, 623hemolysin production, 192lactoferrin, 623M. paratuberculosis, 623P. aeruginosa, 263, 885pyocyanin, 263siderophores, 885transferrin, 263, 623, 885

JirdsD. viteae, 742immune response

cellular, 742humoral, 742

Kidneysmonoclonal antibodies, 230S. mansoni antigens, 230

Lactobacillus caseienhanced hematopoietic response, 156

Lactoferrinbovine paratuberculosis, 623granulomas, 623

Legionella pneumophilalipopolysaccharides, 676serological characterization, 676

Leishmania mexicana subsp. mexicanamacrophages, 36promastigotes

binding, 36uptake, 36

Leishmania promastigotesbinding, 36uptake, 36

Leishmaniasismetastatic disease, 364pathophysiology, 364

Lens culinarislectin, 309mitogenesis, 309M. tuberculosis, 309phytohemagglutinin, 309

Leprosy

interleukins, 303macrophages, 303

Lethal factor componentsanthrax toxin, 356B. anthracis, 356protective immunity, 356

Lipidsendotoxemia, 905endotoxins, 6, 613, 872glycolipids, 777lipid A, 6, 905lipopolysaccharides, 777lymphocytes, 777peroxidation, 613phospholipids, 777protection, 905Salmonella-type lipid A, 872

Lipopolysaccharidesantigenic variation, 337antigens, 76C. burnetii, 337characterization

electrophoretic, 676serological, 676

colimycin, 725complexing, 644E. coli, 617endotoxemia, 905endotoxin tolerance, 6IATS serotype 6, 76lipid A, 905L. pneumophila, 676lung surfactant, 644lymphocytes, 777membrane lipids, 777monoclonal antibodies, 617monophosphoryl lipid A, 6opsonins, 617P. aeruginosa vaccines, 76, 161plasminogen antiactivator, 725polymyxin B, 725polysaccharide-toxin A conjugate, 161stimulation, 777S. typhimurium, 6

Liposomescarbohydrate-protein conjugate, 408S. mutans, 408

Listeria monocytogenescyclosporin A, 12enhanced resistance to, 730hemolysins, 50host defenses, 493human sera, 493inhibition, 12listericidal activity, 688macrophages, 688, 730opsonins, 493pregnancy, 730serum amyloid P component, 688T-cell induction, 401transposon mutagenesis, 50virulence, 50

Listericidal activityL. monocytogenes, 688macrophages, 688serum amyloid P component, 688

Local active gingival immunizationcaries, 682S. mutans, 682streptococcal antigen, 682

Lungsantimicrobial activity, 853complement, 853

INFECT. IMMUN.

SUBJECT INDEX vii

P. aeruginosa, 853P. aeruginosa cytotoxin, 846pulmonary microvascular injury, 846

Lung surfactantcomplexing, 644lipopolysaccharides, 644

Lymphocyteslipopolysaccharides, 777membrane lipids, 777M. pulmonis, 594polyclonal activation, 594stimulation, 777

Lysozymecell walls, 803complement fixation, 803Streptococcus spp., 803

MacrophagesB. fragilis, 488B. malayi, 534"C. parvum," 534enhanced resistance, 730fusion inhibition, 252interleukins, 303killing mechanisms, 151leprosy, 303listericidal activity, 688L. mexicana subsp. mexicana, 36L. monocytogenes, 688, 730M. avium, 252M. bovis, 534metabolism, 236microfilarial cytotoxicity, 534monoclonal antibodies, 36ontogeny, 236P. acnes, 534phagocytosis, 488phagosomes, 252pregnancy, 730promastigotes, 36serum amyloid P component, 688superoxide anion release, 236T. gondii, 151

MalariaP. chabaudi adami, 637resistance, 637T-cell immunity, 637

Membrane damageE. coli hemolysin, 63transmembrane pore generation, 63

Meningitisbacterial growth rates, 484E. coli, 213neonatal septicemia, 213S. pneumoniae, 484

Metastatic diseaseleishmaniasis, 364parasites, 364

Methylprednisolonebacterial clearance, 26endotoxin liberation, 26experimental sepsis, 26

Microfilarial cytotoxicityB. malayi, 534macrophages, 534M. bovis, 534P. acnes, 534

MigrationFc receptors, 798phagocytosis, 798polymorphonuclear leukocytes, 798

Mitogenesisinhibition, 309

Lens culinaris lectin, 309M. tuberculosis, 309phytohemagglutinin, 309

Monoclonal antibodiesantigens, 786Aotus monkey immunity, 314Borrelia spp., 549C. botulinum, 786characterization, 56C. perfringens enterotoxin, 31E. coli, 56, 110, 617endotoxins, 56epitopes, 549glycoprotein immunogen, 70lipopolysaccharides, 617L. mexicana subsp. mexicana

binding, 36uptake, 36

opsonins, 617P. aeruginosa, 756peritoneal macrophages, 36P. falciparum, 314polysaccharide antigen, 628production, 31protection, 617recombinant T. pallidum immunogen,

110renal pathology, 230S. mansoni antigens, 230S. mutans, 628toxins, 756, 786T. vaginalis, 70

Monophosphoryl lipid Aearly-phase endotoxin tolerance, 6S. typhimurium, 6

Mouse modelcutaneous infection, 707Staphylococcus spp., 707

Mouse small intestineE. coli, 18mucosal receptors

characterization, 18identification, 18

Mucosal receptorscharacterization, 18E. coli, 18identification, 18mouse small intestine, 18

Multiplication ratesH. influenzae type b

in vitro, 911in vivo, 911

Murine antibody responseG. muris, 271gut secretions, 271

Mutanolysinarthritis, 459cell wall degradation, 459

Mycobacterial genomic librariesrecombinant cosmid molecules, 101S. mutans, 101S. typhimurium, 101

Mycobacterium aviumfusion inhibition, 252macrophages, 252phagosomes, 252

Mycobacterium bovis BCGB. malayi, 534macrophages, 534microfilarial cytotoxicity, 534P. acnes, 534protein characterization, 293

Mycobacterium leprae

interleukins, 303macrophages, 303

Mycobacterium paratuberculosisgranulomas, 623iron metabolism, 623

Mycobacterium tuberculosisLens culinaris lectin, 309mitogenesis, 309phytohemagglutinin, 309

Mycoplasma pneumoniaefibroblasts, 240glutathione redox cycle, 240vitamin E, 240

Mycoplasma pulmonislymphocytes, 594polyclonal activation, 594

Neisseria gonorrhoeaeantimicrobial activity, 384arthropathic activity

disseminated disease, 600peptidoglycan fragments, 600

genetic characterization, 529granulocytes, 384outer membrane proteins, 529pyocin, 384

Neonatal septicemiaE. coli, 213meningitis, 213

Neutrophil receptorsintracellular killing, 245P. mirabilis, 245

NeutrophilsB. abortus, 285bacterial competition, 657oxygen consumption, 657preferential inhibition, 285primary granule release, 285serological characterization, 657

Nocardia rubracell wall skeleton, 128C3H/HeN mice, 128colony-stimulating factor, 128

Nucleotide sequenceS. pyogenes bacteriophage T12, 144type A exotoxin gene, 144

Oligomannoside-type glycopeptidesadhesion inhibition, 428E. coli, 428type 1 pili, 428

Opsoninsantibodies, 892chemotaxins, 748complement, 892E. coli, 617, 892hepatic clearance, 499host defense, 493human sera, 493lipopolysaccharides, 617L. monocytogenes, 493monoclonal antibodies, 617neutrophil-mediated killing, 748rough mutants, 892Salmonella spp., 892S. mansoni, 748S. pneumoniae, 499

Oral microorganismscontinuous culture, 897glucose limitation, 897growth parameters, 897molar fissures, 620monoinfected rats, 620

VOL. 52, 1986

viii SUBJECT INDEX

Streptococcus spp., 620variable colonization, 620

Otitis mediaantibodies, 572H. influenzae, 572

Outer membrane proteinsantigenic variation, 529genetic characterization, 529, 812H. influenzae type b, 812H. pleuropneumoniae, 414N. gonorrhoeae, 529profiles, 414

Oxygen consumptionbacterial competition, 657neutrophils, 657

Parasitesmurine malaria, 637P. chabaudi adami, 637resistance, 637S. japonicum, 513T-cell immunity, 637

Pasteurella multicidaatrophic rhinitis, 175cell surface proteins, 175

Pellicle receptorsattachment to, 555S. mutans, 555S. sobrinus, 555

penB locusantigenic variation, 529N. gonorrhoeae, 529outer membrane proteins, 529recombination, 529

PeptidesC. albicans, 902rabbit granulocytes, 902synergistic activity, 902

Peptidoglycan fragmentsarthropathic activity, 600N. gonorrhoeae, 600

Peptidoglycan-polysaccharide fragmentsdegradation, 390group A and D streptococci, 390

Periodontal diseasefluoride, 914pathogens, 768systemic host response, 768T. denticola, 914

Peritoneal exudate neutrophilscell surface receptors, 245intracellular killing, 245P. mirabilis, 245

PhagocytosisB. fragilis, 488Fc receptors, 798inhibition, 488macrophages, 488migration, 798polymorphonuclear leukocytes, 798

Phagosomesfusion inhibition, 252macrophages, 252M. avium, 252

PhytohemagglutininLens culinaris lectin, 309mitogenesis, 309M. tuberculosis, 309

PiliE. coli, 428glycopeptides, 428type 1 pili, 428

Plant lectins

adherence, 840A. naeslundii, 840glycoproteins, 840

Plaquefluoride, 914oral microorganisms

characterization, 897growth parameters, 897

T. denticola, 914Plasmids

B. anthracis, 454exotoxin A gene, 538immunization studies, 454P. aeruginosa, 538toxins, 454V. cholerae, 476virulence, 476

Plasminogen antiactivatorcolimycin, 725endothelial cells, 725lipopolysaccharides, 725polymyxin B, 725

Plasmodium chabaudi adamimurine malaria, 637T cells, 637transfer of resistance, 637

Plasmodium falciparumAotus monkey immunity, 314monoclonal antibodies, 314

Pneumococcal capsular polysaccharideantibody response, 867immunoglobulins, 867

Pneumoniacomplexing, 644lipopolysaccharides, 644lung surfactant, 644

Polyclonal activationM. pulmonis, 594rat splenic lymphocytes, 594

Polymorphonuclear leukocytesbactericidal protein, 90chemiluminescent response, 397chemotaxis, 664, 748Chlamydia spp., 664Fc receptors, 798H. influenzae, 397"H. somnus," 792migration, 798neutrophil suppression, 792opsonins, 748P. aeruginosa, 90phagocytosis, 798S. mansoni, 748S. pneumoniae, 397

Polymyxin Bcolimycin, 725endothelial cells, 725lipopolysaccharides, 725plasminogen antiactivator, 725

Polysaccharidesimmunoglobulins, 867S. mutans antigen, 628type 6 pneumococci, 867vaccines, 867

Porin antigensS. typhi, 209typhoid infection, 209

Pregnancyenhanced resistance, 730L. monocytogenes, 730macrophages, 730

Primary granule releaseB. abortus, 285

neutrophils, 285preferential inhibition, 285

ProgesteroneT. mentagrophytes

binding, 763inhibition, 763

Promastigotesbinding, 36L. mexicana subsp. mexicana, 36monoclonal antibodies, 36uptake, 36

Propionibacterium acnesB. malayi, 534enhanced hematopoietic response, 156L. casei, 156macrophages, 534M. bovis, 534microfilarial cytotoxicity, 534

Protease productionB. catarrhalis, 631immunoglobulins, 631

Proteinsadherence, 840A. naeslundii, 840antigenic variation, 529atrophic rhinitis, 175bactericidal protein, 90binding, 714cell surface proteins, 175characterization, 293genetic characterization, 529, 609group A streptococci, 609H. influenzae type b, 812H. pleuropneumoniae, 414M. bovis BCG, 293M protein, 609outer membrane proteins, 414, 529, 812P. aeruginosa, 90physiological effects, 90P. multocida, 175polymorphonuclear leukocytes, 90recombination, 529R. rickettsii, 120S. aureus, 714serum spreading factor, 714

Proteolytic enzymesburn wounds, 200C. albicans, 200P. aeruginosa, 200

Proteus mirabiliscell surface receptors, 245intracellular killing, 245peritoneal exudate neutrophils, 245

Pseudomonas aeruginosabactericidal protein, 90burn wounds, 200C. albicans, 200complement, 853cytotoxin, 846enhanced susceptibility to, 200exotoxin A, 96, 538genetic characterization, 538immune response suppression, 96immunotype 5 polysaccharide, 161iron metabolism, 263, 885killing, 853lipopolysaccharides, 76lungs, 853monoclonal antibodies, 756polymorphonuclear leukocytes, 90protective antigen, 76proteolytic enzymes, 200pulmonary microvascular injury, 846

INFECT. IMMUN.

SUBJECT INDEX ix

pyocyanin, 263rabbit lungs, 846siderophores, 885toxin A, 161, 756transferrin, 263, 885vaccines, 76, 161virulence, 538

Pseudomonas exotoxin Acharacterization, 445fibroblasts, 445

Pulmonary microvascular injuryP. aeruginosa cytotoxin, 846rabbit lungs, 846

Pyocinantimicrobial activity, 384granulocytes, 384N. gonorrhoeae, 384

Pyocyaniniron metabolism, 263P. aeruginosa, 263transferrin, 263

Q feverantigenic variation, 337C. burnetii, 337lipopolysaccharides, 337

Rabbit granulocyte peptidesC. albicans, 902synergistic activity, 902

Rat peritoneal macrophageskilling mechanisms, 151T. gondii, 151

Receptorsadherence, 840A. naeslundii, 840Fc, 798glycoproteins, 840migration, 798pellicle, 555phagocytosis, 798polymorphonuclear leukocytes, 798S. mutans, 555S. sobrinus, 555

Recombinant cosmid moleculesin vivo repackaging, 10imycobacterial genomic libraries, 101S. mutans, 101S. typhimurium, 101

Recombinant DNA-derived immunogenE. coli, 110monoclonal antibodies, 110T. pallidum, 110

Rickettsia conoriiantigens, 326T-cell hybridomas, 326

Rickettsia rickettsiiantigen detection, 120humoral immune response, 120protein immunoprecipitation, 120Rocky Mountain spotted fever, 120

Rickettsia tsutsugamushigamma radiation, 718host defenses, 718scrub typhus, 718

Rocky Mountain spotted feverantigen detection, 120humoral immune response, 120protein immunoprecipitation, 120R. rickettsii, 120

Rough mutantsantibodies, 892complement, 892

E. coli, 892opsonins, 892Salmonella spp., 892

Salivaantibody responses, 408S. mutans, 408

Salmonella antigensimmunoglobulin subclass patterns, 834S. flexneri, 834

Salmonella spp.antibodies, 892complement, 892opsonins, 892rough mutants, 892

Salmonella typhiantibodies, 209porin antigens, 209typhoid infection, 209

Salmonella typhimuriumdelayed-type hypersensitivity, 504endotoxin, 6epithelial cell invasion, 828immunity, 504interferons, 828lipid A derivative, 6mycobacterial genomic libraries, 101recombinant cosmid molecules, 101S. mutans, 101

Schistosoma japonicumgranulomatous inflammation, 513modulation, 513parasites, 513

Schistosoma mansoniantigens, 230chemotaxins, 748cyclosporin A, 823monoclonal antibodies, 230neutrophil-mediated killing, 748opsonins, 748protection against, 823renal pathology, 230

Scrub typhusgamma radiation, 718R. tsutsugamushi, 718

Serological characterizationantibodies, 572bacterial competition, 657C. jejuni, 702enteritis, 702H. influenzae, 572

nontypable, 183type b, 183

host defenses, 493lipopolysaccharides, 676L. monocytogenes, 493L. pneumophila, 676molecular oxygen, 657neutrophils, 657opsonins, 493otitis media, 572

Serum amyloid P componentlistericidal activity, 688L. monocytogenes, 688macrophages, 688

Serum spreading factorbinding, 714S. aureus, 714

Shigella flexneriimmunoglobulins, 834lipopolysaccharides, 834Salmonella antigens, 834

Shigella spp.

epithelial cell invasion, 828interferons, 828

Siderophoresiron acquisition, 885P. aeruginosa, 885transferrin, 885

speA geneDNA sequence, 144S. pyogenes bacteriophage T12, 144

Staphylococcal membrane receptorsdetection, 671direct adhesin overlay, 671S. aureus, 671

Staphylococcus aureusbinding, 714direct adhesin overlay, 671hormones, 331membrane receptors, 671proteins, 714serum spreading factor, 714toxic shock syndrome, 331

Staphylococcus spp.cutaneous infection, 707mouse model, 707

Streptococcus mutansantibodies, 408antigens, 682attachment, 555carbohydrate-protein conjugate, 408caries prevention, 682fructosyltransferase gene

characterization, 166isolation, 166

gingival immunization, 682liposomes, 408monoclonal antibodies, 628mycobacterial genomic libraries, 101pellicle receptors, 555polysaccharide antigen, 628recombinant cosmid molecules, 101S. sobrinus, 555S. typhimurium, 101

Streptococcus pneumoniaebody temperature, 484characterization, 484hepatic clearance, 499H. influenzae, 397meningitis, 484opsonins, 499polymorphonuclear leukocytes, 397

Streptococcus pyogenesbacteriophage T12, 144DNA sequence, 144type A exotoxin, 144

Streptococcus sobrinusattachment, 555pellicle receptors, 555S. mutans, 555

Streptococcus spp.cell wall degradation, 390complement fixation, 803group A and D, 390lysozyme, 803oral colonization, 620phlogistic capacity, 803

Superoxide anion releasemacrophage ontogeny, 236macrophages, 236

Suppressive components"H. somnus," 792polymorphonuclear leukocytes, 792

Synthetic peptidescholera toxin, 562

VOL. 52, 1986

x SUBJECT INDEX

Synth¢tic peptideschoera toxin, 562E. coli enterotoxins, 562enhanced immunity, 562

SyphilisT. pallidumantibody binding, 579antigen 4D, 579

Systemic host responseoral pathogens, 768periodontitis, 768

T cellsantigens, 326characterization, 401hybridomas

characterization, 326production, 326

isolation, 401L. monocytogenes, 401murine malaria, 637P. chabaudi adami, 637R. conorii, 326transfer of resistance, 637

T lymphocytesabscess formation, 633nonimmune mice, 633

Toxic shock syndromehormonal influence, 331S. aureus, 331toxin-1

clearance, 134S. aureus, 134

Toxinsanlinopyridines, 858anthrax toxin, 356antigens, 786B. anthracis, 454B. bronchiseptica, 370botulism, 858C. botulinum, 786, 858cholera, 562clearance, 134C. perfringens enterotoxins, 31cytotoxins, 846dermonecrotic toxin, 370E. coli, 468, 562EP. coli STb enterotoxin, 323endotoxins, 872enterotoxins, 468, 562fibroblasts, 445immune response suppression, 96immunization studies, 454monoclonal antibodies, 31, 756, 786P. aeruginosa, 161, 846P. aeruginosa toxin A, 96, 445, 756plasmids, 454

pulmonary microvascular injury, 846Salmonella-type lipid A, 872speA gene, 144staphylococcal toxic shock syndrome

toxin-1, 134toxin A, 161type A exotoxin, 144vaccines, 161V. cholerae, 45

Toxoplasma gondiikilling, 151rat peritoneal macrophages, 151

Transferrinbovine paratuberculosis, 623granulomas, 623iron acquisition, 263P. aeruginosa, 263, 885pyocyanin, 263siderophores, 885

Transposonshemolysins, 50L. monocytogenes, 50mutagenesis, 50virulence, 50

Treponema denticolafluoride, 914plaque, 914

Treponema pallidumantibody binding, 579complement, 579E. coli, 110E. coli outer membrane, 586extracellular matrix, 736fibronectin attachment, 736monoclonal antibodies, 110recombinant antigen, 579, 586recombinant DNA-derived immunogen,

110Trichomonas vaginalis

heterogeneity, 70major surface immunogen, 70monoclonal antibodies, 70

Trichophyton mentagrophytesprogesterone

binding, 763inhibition, 763

TrophozoitesG. muris, 568immunoglobulins, 568mouse intestines, 568

Trypanosoma brucei subsp. gambiensecomplement pathway restriction, 223killing, 223

Tuberculosisactive inflammation, 341interleukins, 341

Typhoid infection

antibodies, 209porin antigens, 209S. typhi, 209

Ureaplasma urealyticumcharacterization, 437

Urinary tract infectionU. urealyticum, 437

VaccinesB. anthracis, 454, 509capsular polysaccharides, 867immunoglobulins, 867live spore, 509P. aeruginosa, 76, 161plasmids, 454polysaccharide-toxin conjugate, 161protective antigen, 76, 509toxin A, 161

Vibrio choleraeE. coli, 279enterotoxin

characterization, 45purification, 45

genetic characterization, 279hemagglutinin gene, 279hemolysin

characterization, 319purification, 319

plasmids, 476virulence, 476V. parahaemolyticus, 319

Vibrio parahaemolyticushemolysins, 319V. cholerae, 319

VirulenceB. gingivalis, 349hemin, 349hemolysins, 50L. monocytogenes, 50plasmid mediation, 476transposon mutagenesis, 50V. cholerae, 476

Vitamin Efibroblasts, 240glutathione redox cycle, 240M. pneumoniae, 240protective effects, 240

WiDr cellsB. pertussis

adherence, 695hemagglutinin, 695

Yersinia enterocoliticaHEp-2 cells, 85serotypic characterization, 85

INFECT. IMMUN.