Innovations - Spring 2014

Inspired by the legacy of its co-founder, the Institute thrives

VISIONARY

LEADING THE CURE FOR CANCER • SPRING 2014

Donald L. Morton, MD 1934 – 2014

2 INNOVATIONS, SPRING 2014

SPRING 2014

ON THE COVERDr. Donald L. Morton was a beloved friend, mentor and colleague to many. To patients, he was a hero. Illustration by Anita Bilan.

INSIDE

10 18The benefits of yoga extend beyond fitness for cancer survivors.

Training young scientists was a hallmark of Dr. Donald L. Morton's career.

3JWCI Faculty

4Letter from the Chairman of the Board

5Welcome from the Institute

6New Faculty

8Research Update

9In the News

10Integrative Health

12Fellows Update

13Former Fellow

14Research on Immunotherapy

16What's Happening

28Memorable Events

38Honor Roll

VISIONARY18The Life and Legacy of Dr. MortonRaised in challenging circumstances, he rose to prominence in oncology.

20To Patients, He Offered HopeFriends and patients recall a compassionate physician.

22His Colleagues Remember a Visionary ManAmong the accolades in his lifetime, Dr. Morton saved the life of the renowned physicist Dr. Richard Feynman.

25Leaving the Institute in Good HandsThe Institute faculty vows to maintain a tradition of excellence.

FACULTY

SPRING 2014, INNOVATIONS 3

JWCI ADJUNCT FACULTY

JWCI FACULTY

Garni Barkhoudarian, MDAssistant Professor of Neuroscience and Neurosurgery Anton J. Bilchik, MD, PhDProfessor of Surgery Chief of MedicineInterim Chief of ScienceChief of the Gastrointestinal Research ProgramLisa Chaiken, MDAssistant Professor of Radiation OncologyMaureen Chung, MD, PhDProfessor of Surgery Director of Margie Petersen Breast CenterDirector of Breast Oncology Fellowship ProgramDirector of Margie and Robert E. Petersen Breast Cancer Research ProgramRebecca Crane-Okada, PhD, RN, CNS, AOCNProfessor of OncologyDirector of Breast Cancer Navigation Program, Margie Petersen Breast CenterL. Andrew Di Fronzo, MDProfessor of SurgeryMaggie DiNome, MDAssistant Professor of SurgeryAssociate Director of Margie Petersen Breast Center

Mark B. Faries, MDProfessor of SurgeryDirector of Complex General Surgical Oncology FellowshipDirector of Donald L. Morton, MD, Melanoma Research ProgramDirector of Therapeutic ImmunologyLeland J. Foshag, MDSurgical OncologistChester F. Griffiths, MDProfessor of SurgeryDave S. B. Hoon, MSc, PhDProfessor and Director of Molecular OncologyChief of Scientific IntelligenceDirector of Genomics SequencingSharon Huang, PhDAssistant Professor of Molecular OncologyReiko F. Irie, MDDirector of BiotechnologyJohn Jalas, MDAssistant Professor of PathologyPeter Jones, MDAssociate Professor of SurgeryDaniel F. Kelly, MDProfessor of Neuroscience and NeurosurgeryDirector of Brain Tumor Center and Pituitary Disorders Program

Delphine J. Lee, MD, PhDProfessor of ImmunologyDirector of Translational ImmunologyLaurent Lessard, MDAssistant Professor of Molecular OncologyDiego Marzese, PhDAssistant Professor of Molecular OncologySebastian J. Sasu, MDAssociate Professor of PathologyPeter A. Sieling, PhDProfessor of ImmunologyAssistant Director of Translational ImmunologyMyung-Shin Sim, MS, DrPHAssociate Professor and Director of BiostatisticsFrederick Singer, MDDirector of Endocrinology and Bone Disease Program Hitoe Torisu-Itakura, MD, PhDAssistant Professor of ImmunologyRoderick Turner, MDProfessor of PathologyJinhua Wang, PhDAssistant Professor of Molecular Oncology

Stan Alfred, MDAdjunct Professor of DermatologyPeter Boasberg, MDMedical OncologyStanley A. Brosman, MDUrologySant P. Chawla, MDMedical OncologyAlistair Cochran, MDPathologyDavid Elashoff, PhDBiostatisticsRobert Elashoff, PhDBiostatisticsJoshua Ellenhorn, MDAdjunct Professor of Surgery Clark B. Fuller, MDCardiovascular/Thoracic SurgeryEdwin Glass, MDNuclear Medicine Omid Hamid, MDMedical Oncology

Vivanti N. Jain, MDAdjunct Associate Professor of Plastic SurgeryJ. Arthur Jensen, MDPlastic SurgeryDavid Krasne, MDPathologyRonald S. Leuchter, MDGynecologic OncologyBrian D. Madden, MDAdjunct Assistant Professor of Palliative CareAli Mahtabifard, MDAdjunct Assistant Professor of Thoracic SurgerySilvana Martino, DOMedical OncologyLisa C. Moore, MDAdjunct Assistant Professor of EndocrinologyCarol Nishikubo, MDMedical Oncology

Steven J. O’Day, MDMedical OncologyJay S. Orringer, MDPlastic SurgeryLawrence D. Piro, MDMedical OncologyLauren L. Reager, MDDermatologyAdriana N. Schmidt, MDAdjunct Assistant Professor of DermatologyIra Smalberg, MDRadiologyMarilou Terpenning, MDAdjunct Professor of Medical OncologyRobert C. Wollman, MDRadiation OncologyPaul S. Yamauchi, MD, PhDAdjunct Professor of Dermatology

JOHN WAYNE CANCER INSTITUTE EDITORIAL STAFF

Acting President and Chief Executive Officer

Michael L. Wall

Chief of Medicine Anton J. Bilchik, MD, PhD

Vice President, Public Affairs and Development

Andy Trilling

Director of Marketing, Public Relations & Communications

Andrea R. Salazar

Marketing Manager Tabitha Ji

VP, Branded Media Emily S. Baker

Art Director Ajay Peckham

EditorShari Roan

Copy Editor Laura Watts

ContributorSandi Draper

PhotographerLauren Pressey

Managing Partners Charles C. Koones

Todd Klawin

INNOVATIONS

Donald L. Morton, MDFaculty Emeritus†

†Deceased

Douglas M. Mancino

Jay B. Lichter, PhD

Anton J. Bilchik, MD, PhD

Michael I. Wayne

Michael L. WallMichael Hunn

LETTER FROM THE CHAIRMAN OF THE BOARD

Meeting the Challenges of CancerCancer research requires dedication, perseverance and hope—all qualities that defined the late Donald L. Morton, MD, co-founder of the John Wayne Cancer Institute. In this issue of Innovations, we honor his legacy and celebrate his accomplishments with great pride. Dr. Morton laid the groundwork for what is now a world-class Institute with faculty who are pioneers in several of the most promising and innovative areas of research such as molecular oncology, immunotherapy and minimally invasive surgical techniques.

My family welcomed the opportunity to use my father’s name to honor his battle against the disease and promote world-class cancer research. Today the Institute is a testament to that vision. The emphasis on translational medicine means our researchers

are working hard to move the discoveries they make in the laboratories to the bedsides of patients as quickly as possible.

Research also requires the resolve and allegiance of the community. You, our supporters and donors, have allowed the pace of our research to accelerate with your gifts of time and funding—and we thank you. Without your generosity and commitment, we would not witness so many significant accomplishments. I hope you feel as proud as I do of our impressive past and promising future.

Patrick Wayne Chairman of the Board of Directors

REMEMBERING THE DUKERIO LOBO, 1970John Wayne stars in the final film of a trilogy directed by the distinguished director Howard Hawks. Rio Lobo was Hawks’ last film. In the movie, Wayne’s character, Col. Cord McNally, searches for a traitor who contributed to the defeat of McNally’s unit and the death of a friend during the Civil War. Wayne’s costars included Jorge Rivero and Jennifer O’Neill with a bit part played by the young actress Sherry Lansing. Lansing left acting shortly thereafter and eventually became CEO of Paramount Pictures.


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JOHN WAYNE CANCER INSTITUTE BOARD OF DIRECTORS

Patrick WayneCHAIRMAN

Randy Axelrod, MD


WELCOME FROM THE INSTITUTE

Life is a series of transitions, and we observe and honor several important transitions that have taken place at the John Wayne Cancer Institute in recent months. First, of course, is to remember with deep appreciation the life and career of our co-founder Donald L. Morton, MD, who passed away earlier this year. Dr. Morton’s contributions to cancer treatment and research are on display daily at the Institute. He worked hard to establish a culture of collaboration and excellence that is paying dividends today.

We also celebrate the new sponsors of Saint John’s Health Center: Providence Health & Services. Under Providence, we find ourselves associated with a large and prestigious healthcare network that understands and appreciates cancer research and the mission of the Institute. We look forward to working with our new colleagues at Providence to find new treatments

and cures for cancer. More than 30 years after its

founding, the John Wayne Cancer Institute ranks at the forefront of innovative cancer research. Earlier this year, one of the most highly regarded medical journals in the world, the New England Journal of Medicine, published a landmark study on sentinel node biopsy for melanoma patients led by members of our staff. We continue to lead or participate in multiple international research collaborations that are solving some of the most pressing questions in oncology.

These successes have generated renewed energy and confidence among our faculty and supporters. As we lay plans for our continued growth and development, we acknowledge with gratitude the many Institute volunteers, supporters and donors without whom we simply could not pursue this vital and challenging work.

On behalf of Providence Health & Services and our Southern California region, it is my great

honor to thank and recognize the donors and supporters of the John Wayne Cancer Institute for your tremendous generosity and dedication to making this wonderful research institute a true resource for the community. As Providence assumes sponsorship, I know that together we are standing on the shoulders of those who have gone before us. With your support, we are confident that we will continue the tradition of excellence that the John Wayne Cancer Institute has created to provide world-class research and make a difference in the lives of all those who come to us.

We want you to know that

the Institute has joined a compassionate and historic organization that serves patients in Alaska, California, Montana, Oregon and Washington state. Providence is the second-largest health system in Los Angeles and the eighth-largest private employer with six medical centers, more than 13,000 employees, 40 clinics, two medical foundations, more than 4,000 physicians and a comprehensive network of care from home care to hospice to long-term care.

We are very humbled and proud to include the John Wayne Cancer Institute in the

Providence family. During this time of great reflection, as we come together, we will be working collaboratively with our donors, boards and supporters as well as the Institute’s leadership and physicians to chart our course for the future. Together we will grow and remain true to our mission of serving those in need and creating healthier communities.

Michael Hunn Senior Vice President, Regional Chief Executive, Providence Health & Services

Honoring the Past, Embracing the Future

Message from Providence Health & Services

Michael L. Wall Acting President and Chief Executive Officer

Anton J. Bilchik, MD, PhDProfessor of Surgery, Chief of Medicine and Chief of the Gastrointestinal Research Program


AT THE FOREFRONT

John R. Jalas, MD, assistant professor of pathologyDr. Jalas' work is motivated by the desire to better

understand the mysteries of cancer and spare more people

from the disease.Dr. Jalas attended college at the University

of Texas. He earned a PhD in chemistry at the University of Minnesota followed by his medical degree there two years later. He completed a residency and a fellowship in surgical pathology at the University of California, San Francisco.

He is currently working on a project to assess the immune response to colon cancer. The goal of the research is to develop an “immunoscore”

that will predict which patients are most and least likely to benefit from chemotherapy.

“Our data will allow patients who won’t benefit from chemotherapy to be spared its side effects,” he explains. “In addition, our data could lend insight into the biology of the immune response to cancer, potentially providing new therapeutic targets.”

Chester F. Griffths, MD, professor of surgery

Born in New York City, Dr. Griffiths attended

Thomas Jefferson University in Philadelphia and is double board-certified in otolaryngology, head and neck surgery and facial plastic and reconstructive surgery. His father, Cadvan Owen Griffiths, Jr., MD, is a much-admired physician who inspired his

son’s career choice. But Dr. Griffiths was motivated to specialize

in cancer because of an undiagnosed ailment he suffered as a child. He was treated at Saint John’s Health Center for three years and decided that he would “become a physician to care for those in need.” He was licensed to practice medicine by the age of 21.

Dr. Griffiths, with Dr. Daniel Kelly, is chief of endoscopic sinonasal and skull base surgery

at the Providence Saint John’s Health Center Brain Tumor Center. His current research projects include advancing minimally invasive procedures for transnasal endoscopic skull base tumors as well as the study of preservation of olfactory function following nasal-skull base surgery. He has presented his research at national and international meetings and has authored numerous published research papers and book chapters.

Lisa Chaiken, MD, assistant professor of radiation oncology

Dr. Chaiken was born in Torrance, California, and

attended Harvard University before entering the University of Califoria, Los

Angeles, medical school. Her residency was in radiation oncology at UCLA. Dr. Chaiken chose that specialty because “cancer is an exciting area of advancements and research,” she says.

Dr. Chaiken has worked on targeted treatments such as stereotactic treatments for

cancer in the brain, the base of the skull and lung, as well as radiation implants for breast and gynecologic tumors. She joined the John Wayne Cancer Institute recently to pursue a special interest in breast cancer, gynecologic tumors, and head and neck cancers.

Introducing the New Faculty

Peter Jones, MD, associate professor of surgeryDr. Jones, a native of

Sacramento, earned a bachelor's degree at the

University of California, Irvine, before attending medical school at the University of California, Los Angeles, where he also completed a general surgery residency, a plastic surgery residency and a surgical oncology fellowship. He was a fellow under the late Donald L. Morton, MD, from 1978 to

1980. Dr. Jones then opened a private practice in plastic and hand surgery in Coeur d’Alene, Idaho, and retired two years ago.

However, a request by Dr. Morton and Dr. Reiko F. Irie, director of biotechnology, altered his retirement plans. They asked Dr. Jones to expand upon the innovative research he had performed in the lab more than 30 years ago involving testing melanoma patients’ serum for an antibody which might affect their clinical course.

Dr. Jones credits Dr. Morton and the

specimen repository as the foundation for innovative research. “This sets the John Wayne Cancer Institute apart from other cancer institutes because we are readily able to correlate the presence or absence of a factor in serum or tissue to the clinical course of patients followed over many years. This enabled the identification of the antibody on which we are now focused. There are many more discoveries waiting to be made locked away in the freezers at the John Wayne Cancer Institute.”

AT THE FOREFRONT


Douglas M. Mancino, one of the country’s top healthcare and tax-exempt organization lawyers, has joined the John Wayne Cancer Institute board of directors. A partner in the

Los Angeles office of Hunton & Williams LLP, he serves as national co-head of his firm’s healthcare practice.

For more than 40 years, Mancino has represented all types of healthcare and nonprofit organizations on tax, business and financial matters. He has extensive experience in audit, appeals and tax controversy issues. He has served as counsel to healthcare clients in a number of cases that have defined the limits of tax-exempt organizations participating in healthcare joint

ventures and addressed the tax-exempt status of health maintenance organizations.

A graduate of the Ohio State University Moritz College of Law, Mancino has authored five books and treatises and more than 85 articles concerning tax-exempt organizations and healthcare issues. He is a former president of the American Health Lawyers Association and has served as vice chair of publications for the American Bar Association’s tax section.

He became acquainted with Saint John’s Health Center and the Institute when he moved to California in 1980. He met Sister Marie Madeleine Shonka, SCL, began advising the hospital and became interested in cancer centers.

“I’ve actually had a lot of experience in representing providers of oncology-related services,” Mancino explains. “I have a keen understanding, from a layman’s point of view, of cancer and its treatments and the research surrounding it.”

In joining the board of the John Wayne Cancer Institute, Mancino says he hopes to support its continued success. “I was impressed by the level of quality that the Institute has, the research it conducts and its reputation nationally. I view this board as an opportunity to provide my experience in governance with a greater-than-usual understanding of the Institute. It’s also an opportunity to learn.”

A resident of Westwood, Mancino is married and enjoys golfing, scuba diving, skiing and boating. He also participates in numerous civic and charitable activities. He is currently chairman of the board of trustees of the Children’s Burn Foundation and a member of the boards of directors of the Irvine Health Foundation, the Media & Policy Center, The Center on Philanthropy & Public Policy and Health Net, Inc. He is a member of the executive board and an executive vice president of the Music Center Leadership Council.

The Institute Welcomes Douglas M. Mancino to the Board

Sebastian Sasu, MD, associate professor

of pathologyDr. Sasu was born in Cluj,

Romania, and received his medical training at the University of Medicine and Pharmacy in Cluj. After fellowships at Tufts

University in Boston and the University of California, Los Angeles, and a residency at the University of Southern California, he joined the Pathology Medical Group at Saint John's Health Center in 2007 and began working with the John Wayne Cancer Institute researchers.

His primary area of interest is biomarker research. Dr. Sasu is trying to identify new, specific cancer markers that can be used for accurate diagnosis or as therapeutic targets.

Dr. Sasu focused on atherosclerosis early in his career, but he eventually grew interested in cancer diagnosis and targeted therapy.

Diego Marzese, PhD, assistant professor of molecular oncology

Dr. Marzese earned a doctorate in molecular biology

from the National University of Cuyo, Argentina, where he studied alterations of genes related to breast cancer. But Dr. Marzese became interested in finding improved treatments for cancer much earlier in life.

At age 16, he was diagnosed and successfully treated for cancer. That experience inspired him to enter the field of cancer research. At the Institute, he has completed a postdoctoral training under Dave S.B. Hoon, PhD, centered on the genomic and epigenomic aberrations in genes that regulate melanoma.

His research concerns cancer that's resistant to treatment and cancer that has spread.

Dr. Marzese is exploring which genes or gene networks are altered to allow melanoma to spread to the brain.

Dr. Marzese is also pursuing system biology and integrative research on the highly aggressive triple-negative breast cancer to identify unexplored potential therapeutic epigenetic targets for this challenging disease.


AT THE FOREFRONT

Making Strides in Therapeutic Immunology A novel cancer therapy that’s under development for metastatic melanoma may also benefit patients with a particularly aggressive type of breast cancer.

The therapy is an individualized treatment using immune cells taken from a patient’s tumor. The tumor sample is placed in a culture, and researchers extract cancer-fighting white blood cells called tumor-infiltrating lymphocytes—or TILs. Billions of copies of these cells are manufactured and then injected back into the patient.

Clinical trials of the therapy, called adoptive cell therapy with autologous TILs, are showing promising results in patients with metastatic melanoma, according to Mark B. Faries, MD, director of the Donald L. Morton, MD, Melanoma Research Program and therapeutic immunology, who has led the research.

Melanoma that has spread from the original tumor to other parts of the body is especially difficult to treat, with five-year survival rates of less than 6%. The problem is that metastatic melanoma is notoriously resistant to chemotherapy and radiation therapy. Some newer medications, such as vemurafenib and ipilimumab, have improved survival rates. Although the response rate of vemurafenib is approximately 80%, the effect of the medication does not last long and recurrence may occur within a year due to the development of drug resistance in cancer cells. The response rate of ipilimumab is as low as 5% to 11%

When conventional treatments have failed, patients are often eager to try adoptive cell therapy. However, it’s available only at a few key centers in the United States, such as the National Cancer Institute, because the production of the cells is logistically and technically difficult. Institute researchers plan to submit an Investigational New Drug application to treat metastatic melanoma with the therapy.

Dr. Faries’ promising results in autologous TILs research prompted questions on whether the approach can apply to other types of cancer. Translating research findings from one type of cancer to another is a hallmark of the Institute.

Hitoe Torisu-Itakura, MD, PhD, assistant professor of immunology, is evaluating the feasibility of an adoptive cell therapy program for application in breast cancer, especially an aggressive type of breast cancer that is frequently resistant to currently available therapy. Dr. Torisu-Itakura and her colleagues have developed standard operating procedures for a planned study and are in the process of validating lab equipment and assays to meet Food and Drug Administration requirements.

+ Dr. Torisu-Itakura’s research receives generous support from the Dr. Miriam & Sheldon G. Adelson Medical Research Foundation, the Associates for Breast and Prostate Cancer Studies (ABCs) and Sharon and David Keller.

Hitoe Torisu-Itakura, MD, PhD, is conducting studies on TILs therapy.

Mark B. Faries, MD, is director of the Donald L. Morton, MD,

Melanoma Research Program and therapeutic immunology.

AT THE FOREFRONT


In the largest study of its kind, researchers have confirmed that a strategy to assess the spread of melanoma—pioneered by scientists at the John Wayne Cancer Institute—saves lives and spares some patients from troubling surgical side effects.

The study, called the Multicenter Selective Lymphadenectomy Trial (MSLT-I), was led by the late Donald L. Morton, MD, and co-authored by his colleagues at the Institute and around the world, including Mark B. Faries, MD, director of the Donald L. Morton, MD, Melanoma Research Program at the John Wayne Cancer Institute. The study validated the use of sentinel node biopsy, the revolutionary procedure developed by Dr. Morton more than 30 years ago.

Dr. Morton suggested that the spread of melanoma could be determined by examining the lymph node closest to the original tumor. Traditionally, doctors removed all of the lymph nodes in the area of the primary tumor to thwart the spread of cancer. However, this extensive surgery increases the risk of pain, infection and long-term swelling.

Dr. Morton suggested, however, that removing only the lymph node closest to the tumor, dubbed the sentinel node, provided an accurate assessment of how the cancer might

spread without having to examine additional nodes. Sentinel node biopsy has been widely embraced and now applies to other cancers, such as breast cancer.

The new study, released in February in the prestigious New England Journal of Medicine, confirms the long-term value of sentinel node biopsy for patients with melanoma. It found that early removal and analysis of the sentinel node at the time of surgery decreased the chances of the melanoma recurring.

After 10 years, among patients who underwent sentinel node biopsy, 71.3% were still free of cancer compared to 64.7% in patients who did not have sentinel node biopsy. For patients with melanoma in their lymph nodes, early treatment using the biopsy technique increased survival by 44%.

The new study should ensure that melanoma patients receive evidence-based sentinel node biopsy as part of the disease assessment. “This publication is the culmination of nearly 20 years of research carried out worldwide,” says Dr. Faries. “We now have the best evidence yet that the sentinel node procedure not only gives patients the most accurate information about their future, it also increases their chances for survival.”

Multi-Center Melanoma Study Published in the New England Journal of Medicine

INTEGRATIVE HEALTH


Research from around the world in breast cancer patients has shown that yoga may be able to help improve physical functioning, sleep and overall quality of life while reducing fatigue, stress and inflammation. With benefits like that, it’s no wonder yoga is increasingly embraced by cancer patients.

A new weekly yoga class offered by the Margie Petersen Breast Center at Providence Saint John’s Health Center is aimed at meeting the demand for yoga among patients and acknowledges growing scientific support for its value. The hour-long classes, which began in early March, are free to breast cancer patients undergoing treatment at the center. The classes are taught by certified yoga instructor and breast cancer survivor Kamla Subramanian, who leads participants through gentle, therapeutic exercises adjusted for each person's level.

Yoga classes are just one example of how cancer treatments have evolved dramatically over the years.

“Twenty years ago, when a woman was diagnosed with breast cancer, the surgeon cut the tumor out and sent the patient off to the oncologist,” says Maureen A. Chung, MD, PhD, director of the Margie Petersen Breast Center,

Many people undergoing conventional cancer treatments are interested in

complementary health practices. This "Integrative Health" column highlights

the research behind various activities and how patients may benefit.

Turning Yoga’s Mystique Toward Breast CancerWRITTEN BY SANDI DRAPER

director of the breast oncology fellowship program and director of the Margie and Robert E. Petersen Breast Cancer Research Program. “Surgeons really didn’t have a lot to offer patients. But now, cancer treatments are more complicated and individualized, and there are more choices. Today we are treating the patient’s whole sense of well-being. Yoga is part of complementary, or integrated, care.”

The program has been so successful, a second class for individuals considered at high risk of developing the disease is now offered, too. Reducing stress is part of a thorough disease-prevention strategy.

“The majority of evidence does indicate that stress—defined as a significant life event—is associated with a higher risk of breast cancer recurrence,” says

Maggie DiNome, MD, medical director of the Cancer Prevention Clinic, chief of general surgery at the Health Center and associate director of the Margie Petersen Breast Center. “There is also evidence that suggests that reducing stress improves survival.”

One study, she notes, assessed the impact of a professional psychological intervention designed to reduce stress in

Participants at a recent yoga program fundraiser

INTEGRATIVE HEALTH

breast cancer patients and found a 45% reduction in breast cancer recurrence and an almost 50% drop in the risk of death. Yoga lowers levels of stress-related hormones, including cortisol, melatonin and GABA.

Another recent study, published in the Journal of Clinical Oncology, found that practicing yoga for as little as three months can reduce fatigue and lower inflammation in breast cancer survivors. On average, fatigue was 57% lower in women who had practiced yoga compared to the non-yoga group, and their inflammation levels were reduced by up to 20%. Those who practiced yoga also experienced improved mood and sleep.

In addition, the more the study participants practiced yoga, the better their results. The women

in the study, which was funded by the National Cancer Institute, had all completed their breast cancer treatments before the study began. They were all new to yoga and practiced yoga in small groups for 12 weeks.

Still, scientific cause-and-effect evidence that yoga can improve outcomes for breast cancer patients is limited, Dr. Chung says. “But what the data demonstrate is that cancer patients who participate in yoga twice a week feel better during treatment and have a better emotional outlook.”

Yoga has many other health benefits that aren’t unique to cancer. Perhaps that’s why the practice has soared in popularity. According to the 2007 National Health Interview Survey, yoga is the sixth most commonly used complementary health practice

among adults, and more than 13 million people practice it.

“Yoga is just a fabulous form of exercise that can help improve circulation and increase blood flow,” says Dr. DiNome. “It is also an effective way to stay fit and control one’s weight.”

Another benefit to yoga is that anyone can participate. “Yoga’s not competitive,” Dr. Chung says. “You are not competing with the person beside you. We want patients to go to the class for themselves. Classes can help with flexibility and stretching to prevent scarring. Just breathing and taking the time to think about yourself is beneficial.”

For more information about the yoga program, please email [email protected] or call 310-582-7100.


yo·ga \yōgə\ noun

a Hindu spiritual discipline that includes breath control, simple

meditation and the adoption of specific

bodily postures; widely practiced for

health and relaxation

Studies show yoga can improve mood and sleep and reduce inflammation.

+ The Cancer Prevention Clinic receives generous support from Martha and David Ho.


IN THE NEWS

The John Wayne Cancer Institute’s surgical oncology fellows are making important contributions to cancer research. Some of their recent presentations and publications include:

VICTORIA O’CONNOR, MD,

the Harold McAlister Charitable

Foundation fellow, presented research

at the Southern California American

Cancer Society meeting in January,

further elucidating the role of magnetic

resonance imaging to screen high-risk

patients or augment the assessment

of breast cancer. Dr. O’Connor also

presented a study at the Society for

Surgical Oncology (SSO) meeting on

a medication therapy for patients with

gastrointestinal stromal tumors.

ELIZABETH A. ARENA, MD, presented a poster at the

SSO meeting on patients with head and neck melanoma.

The research suggests that removing the parotid gland to

assess for cancer should be strongly considered in patients

with metastases in the neck. While removing the gland has

the potential for complications, the study found that patients

with deep melanoma lesions and lesions located in the front

scalp may benefit the most from parotidectomy.

GARY B. DEUTSCH, MD, MPH, presented a paper at

the SSO meeting on patients with gastric cancer. The study

found that inclusion of information on the number of lymph

nodes tested for cancer to the current cancer staging system

more accurately predicts five-year survival. Dr. Deutsch

also has a case report in press in the Journal of the American Medical Association regarding a unique case involving a

patient with a small bowel obstruction.

NEFERTITI A. BROWN,

MD, the Institute’s Auxiliary

breast fellow, presented

data at the Pacific Coast

Surgical Association meeting

in February demonstrating

the value of MRI to detect

breast cancer tumors in the

contralateral breast that are

not found by conventional

imaging techniques.

SIMON LAVOTSHKIN, MD, a

first-year fellow in complex general

surgical oncology, presented a study

on immunoscoring of colon cancer

in May during Digestive Diseases

Week, the world’s largest gathering

of physicians and researchers in

gastroenterology, hepatology,

endoscopy and GI surgery. In addition,

Dr. Lavotshkin’s study has been

accepted for plenary presentation at

the May annual meeting of the Society

for Surgery of the Alimentary Tract.

Keeping Up With the Fellows

AT THE FOREFRONT


Former Institute Surgical Oncology Fellow Awarded NCI GrantA former surgical oncology fellow at the John Wayne Cancer Institute, Dr. Partha Ray, has received a $1 million Small Business Technology Transfer grant from the National Cancer Institute to advance research he began at the Institute on a diagnostic test for a deadly form of breast cancer.

Dr. Ray, a surgical oncologist with the Carle Cancer Center/Mills Breast Cancer Institute in Urbana, Illinois, participated in a surgical oncology fellowship at the Institute from 2008 to 2010. Under the tutelage of Donald L. Morton, MD, Dr. Ray began work on a molecular diagnostic test to identify a gene, dubbed FOXC1, which is a biomarker for basal-like breast cancer.

This cancer is a form of triple-negative breast cancer, a dangerous sub-type of the disease. But even among cases of triple negative breast cancer, the basal-like form is the most worrisome. These cancers tend to occur more frequently in younger women, African-American women and those with the BRCA-1 gene mutation.

The grant will enable Dr. Ray, an assistant professor of surgery at the University of Illinois, to conduct a multi-institutional clinical trial on as many as 1,000 patients to demonstrate the test’s validity. “The idea is to develop a standard commercial test that any cancer center can use,” he explains. “It can’t be a complicated or expensive test. Expensive and complicated tests often plague the breast cancer field. If you can’t afford it or use it, how useful is the test?”

Dr. Ray, who was a Harold McAlister Charitable Foundation fellow, credits his training at the John Wayne Cancer Institute for his approach to research. He praises the Institute’s philosophy of allowing fellows the freedom to pursue a research project under close mentorship.

“The Institute leadership encourages scientific inquiry and challenges the new minds entering the field to really be able to accurately describe the most pressing problems in surgical oncology today and then fosters skills to solve them,” he explains. “I feel these

skills have been imparted to me. You can only get this when you are allowed an open forum to raise these questions, where you can be mentored in your

research approach.” The Institute faculty is always delighted to hear about the

accomplishments of former fellows, says Mark B. Faries, MD, director of the Institute's complex general surgical oncology

fellowship program. “The men and women in our fellowship program

represent the best and brightest of a new generation of oncology surgeons,” says Dr. Faries. “Dr. Ray maximized

the opportunities provided by his training at the Institute and is now carrying the Institute’s ideals to other regions of the country and to his current colleagues and students. We are tremendously proud of his work and the impact he’s having on the field.”

The Institute leadership challenges new minds entering the field to accurately describe the most pressing problems in surgical oncology, and fosters skills to solve them.”

—Partha Ray, MD, Harold McAlister Charitable Foundation Fellow, John Wayne Cancer Institute, 2008-10


AT THE FOREFRONT

It may seem as if bacterial infections, such as pneumonia, would have little to do with melanoma or breast cancer. But Peter A. Sieling, PhD, a cellular immunologist, has spent his career making a connection between the two seemingly disparate fields. Now he appears to be in just the right place at the right time, as scientific evidence mounts suggesting the body’s own natural system for fighting infections may be the key to preventing or treating some types of cancers.

The role of the immune system is to recognize and eliminate challenges from harmful substances, like germs, and cancerous cells. “The immune system in relationship to

cancer has similar but also different questions,” he says. “The types of cells in our body that fight against tumors—the immune cells—are almost identical to the cells that fight microbial infections.”

Dr. Sieling earned his PhD studying bacterial infections and went on to investigate how the immune system responds to bacterial infections, an area he has worked in for 20 years. During that time, something interesting was brewing in cancer research: the notion that the immune system plays an important role in the development of at least some types of cancer. He was intrigued with applying his expertise to cancer. For almost three years, he has been

working in the field of tumor immunology at the John Wayne Cancer Institute. “I thought this was a wonderful place to apply all of these principles,” he says.

His work is performed at the Institute’s Dirks/Dougherty Laboratory for Cancer Research. “He has a vast expertise in immunology,” says his colleague, Delphine J. Lee, MD, PhD, director of translational immunology at the Institute. “He’s very focused. He’s a stable force. He has great integrity. I just like to work with good people, and he’s good in all ways: brilliant in his knowledge, brilliant in the technical aspects and an overall good person.”

Unlocking The Mysteries Of Cancer And The Immune SystemWRITTEN BY SHARI ROAN

Peter A. Sieling, PhD, is researching the role of

the immune system and cancer development.

AT THE FOREFRONT


Dr. Sieling’s projects include studies on Bacille Calmette-Guérin (BCG). In some melanoma patients, administering doses of BCG stimulates the immune system to fight the cancer.

“We don’t know all of the reasons why it works. But we are hypothesizing that it’s because the immune system recognizes mycobacteria,” he explains.

He hopes to elucidate how BCG works against melanoma in order to refine the therapy. For example, it may be possible to give patients components of some type of bacterium that fights melanoma while removing the dangerous or unnecessary parts of the microbe.

He is also exploring evidence that the immune response has a role in recognizing and eliminating breast cancer. Breast cancer is a disease with many sub-types. Studies are needed to identify which sub-types of breast cancer would respond best to immune system therapies.

Much of Dr. Sieling’s research explores the behavior of immune-system cells called lymphocytes. These cells— T cells, T helper cells and cytotoxic T cells—all have specific roles. One of his studies involves isolating cells in several areas: in the breast cancer tumor, near the tumor and far from the tumor. That information could explain how the various lymphocytes are functioning in relation to the cancer.

“We’re studying the mechanisms to try to understand them better because these therapies don’t work in 100% of cases,” he says. “The immune system is so complex. Some therapies may work in some patients but not others.”

Immunotherapies hold great promise because they target the molecular underpinnings of the cancer and would be unlikely to carry the kinds of side effects associated with less-targeted treatments, such as chemotherapy. One immune system therapy is already approved for melanoma—an immunomodulator called ipilimumab.

“We’re convinced in the case of melanoma that the immune system is vital to recognize and eliminate the tumors,” he says. “In some other cancers, the jury is still out. But it’s clear that the immune system functions to eliminate and prevent many types of cancer.”

The types of cells in our body that fight against tumors—the immune cells—are almost identical to the cells that fight microbial infections."

+ Dr. Lee’s research receives generous support from the Associates for Breast and Prostate Cancer Studies (ABCs), the Avon Foundation, the Carolyn Dirks and Brett Dougherty/Joseph B. Gould Foundation and NIH grants.

DOES BACTERIA PLAY A ROLE IN BREAST CANCER?

A surprising finding by Delphine J. Lee, MD, PhD, about the role of bacteria in influencing breast cancer was published recently in the journal PLOS ONE. The paper will help advance the growing field of cancer immunology, which explores the role of infections and immune system response in cancer.

Some bacteria, such as the human papilloma virus, can cause cancer. HPV is a major cause of cervical cancer. But bacteria can be beneficial too. That’s the focus of the study by Dr. Lee, director

of the department of translational immunology and the Dirks/Dougherty Laboratory for Cancer Research at the John Wayne Cancer Institute.

Dr. Lee found evidence that bacteria are more prevalent in healthy breast tissue compared to tissue from a cancerous breast tumor. Moreover, the study showed that the fewer bacteria present in breast tumor tissue, the greater the odds that the patient had advanced disease. So measuring the amount of bacteria could provide information on diagnosing and staging breast cancer.

It’s not surprising that bacteria can have a positive impact on health. The human body is awash in microbes that perform important functions. For example, bacteria in the intestines helps digest food and keep the cells that line the intestinal tract healthy.

The same thing may be happening in breast tissue. Bacteria may help keep breast tissue healthy and reduce the potential for cancer to develop. It’s possible, Dr. Lee suggests, that bacteria in breast tissue rallies immune cells to do their jobs in fighting off cancer. Healthy levels of bacteria may have cancer-fighting properties in other parts of the body too. With further research, it may be possible to use bacteria to create strategies to prevent cancer or new therapies to stop cancer in its tracks.

“To prevent breast cancer, we must understand the cause and the conditions that foster its development,” she explains. “This research is a new step toward that understanding.”

Delphine J. Lee, MD, PhD

WHAT'S HAPPENING


September 6–7Avon Walk for Breast CancerSanta Barbara, CA The Santa Barbara coastline and Santa Ynez Mountains provide the stunning backdrop for the 29-mile Avon Walk. Launched in 2003 by the Avon Foundation, the two-day event raises funds for breast cancer programs. The John Wayne Cancer Institute is proud to partner once again with Avon as a beneficiary, the medical sponsor and a sponsor of the dedicated volunteers and participants.

October 8QVC Presents FFANY “Shoes on Sale” The Waldorf Astoria, New York, NYThe John Wayne Cancer Institute is honored to be a partner at the 21st annual QVC Presents “FFANY Shoes on Sale” event. Over the years, the Fashion Footwear Association of New York Charitable Organization (FFANY) has contributed more than $5 million to the Institute in support of novel and impactful breast cancer research that has helped eliminate patient suffering for women around the world.

September 10Planned Giving Donor Recognition LuncheonRiviera Country Club, Pacific Palisades, CAThe Guardians of the Future, a distinctive group of individuals who have provided support for the John Wayne Cancer Institute through either their estate plans or other charitable gift planning, will gather with their Providence Saint John’s counterparts, the Friends for the Future, for an update on the latest news and research at the Institute and the Health Center at this annual recognition luncheon.

WHAT'S HAPPENING


October 23JWCI Auxiliary Membership LuncheonBeverly Wilshire,Beverly Hills, CAThe highly anticipated annual boutique and luncheon helps support the operations of the John Wayne Cancer Institute Auxiliary, which has successfully raised millions of dollars for the Institute over the past 29 years.

November 22Associates for Breast and Prostate Cancer Studies (ABCs) Annual “Talk of the Town” Fundraising GalaBeverly Hilton Hotel, Beverly Hills, CAOn an extraordinary evening in November, the ABCs will recognize individuals who have made a difference in the fight against cancer. This glittering, black-tie event attracts more than 800 guests as well as major media attention. Celebrities and supporters alike gather to raise critical funds for the Institute’s breast and prostate cancer research. The celebratory evening includes dinner, dancing, guest performances, a boutique and an auction.

December 7Benefactors DinnerFour Seasons Hotel, Los Angeles, CAOur benefactors are an integral part of the John Wayne Cancer Institute’s continued success and achievements in the fight against cancer. The Institute will honor the generosity of donors who have helped us carry out our mission by supporting innovative cancer research at the highest levels of giving in 2014. Attendees will meet with members of the Wayne family and the Institute’s faculty and fellows and will hear updates and research highlights.

For more information

on any of the events,

please contact us at

[email protected]

or 310-315-6111.

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Advances in neurosurgery

150 fellows trained

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Sequencing Center

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1.5 million samples Cancer biomarkers

Bacillus Calmette-Guérin therapy

Next-generation immunotherapies

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Early Vaccine

Development

The influential work of Donald L. Morton, MD, established strong roots.

REMEMBERING A GIANT

"A Tree is Known by its Fruit."

-Proverb

"A Tree is Known by its Fruit."


VISIONARY

From the humblest beginnings, Donald L. Morton, MD, became the pride of his family, an internationally recognized leader in the field of surgical oncology, and a friend and mentor to many. Dr. Morton died at Saint

John’s Health Center on January 10 at age 79.Dr. Morton co-founded the John Wayne Cancer Clinic at

the University of California, Los Angeles, in 1981. The clinic moved to Saint John’s Health Center and became the Institute in 1991. Standing on the shoulders of their co-founder, the Institute staff grew in prominence to become one of the most reputable cancer research organizations in the world. But Dr. Morton never lost sight of his roots, always stressing the importance of education and the value of having good friends and a loving family.

He was born during the Depression in Richwood, West Virginia, in a home with no electricity, running water or indoor plumbing. His father was a coal miner and built the family’s small house. Dr. Morton loved learning and attended classes at Berea College in Kentucky before transferring to the University of California, Berkeley, where he earned his degree in 1955. He was awarded his medical degree from the University of California, San Francisco, in 1958.

He completed a fellowship at the National Institutes of Health and then joined UCLA. He eventually became chief of general surgery and chief of the division of oncology.

In the 1970s, Dr. Morton turned his attention to a vexing problem in cancer surgery. Cancer often becomes life-threatening when cells break away from the original tumor and spread to lymph nodes where they can easily travel to other organs and tissues.

Forty years ago, doctors treating patients for certain types of cancer, such as breast cancer and melanoma, removed many lymph nodes in order to stop the cancer’s spread. The removal of so many nodes caused severe side effects for patients and

increased the cost of surgery and length of recovery time.But Dr. Morton suggested that removing and analyzing

a single lymph node nearest the tumor was all that was needed to assess the risk of cancer metastasis. Studies proved him correct. The sentinel node biopsy became the standard procedure in oncology.

In the late ‘70s, Dr. Morton treated actor John Wayne, who was suffering from stomach cancer. As with all of his patients, Dr. Morton did his best to help Wayne, even administering an experimental treatment.

Wayne died in 1979, but Dr. Morton and the Wayne family honored the late actor’s battle with the disease by establishing the John Wayne Cancer Institute.

Over the last 32 years of his career, Dr. Morton continued to make noteworthy contributions to his field. He became interested in melanoma and created one of the first experimental vaccines to treat the disease. The approach to treating cancer by harnessing the body’s immune system—the foundation of cancer vaccines—has been adopted by research teams around the world to treat various forms of cancer.

He was also ahead of his peers in anticipating the genetics era of cancer research. Early on, Dr. Morton began preserving biopsy specimens, and today the Institute is home to one of the most important specimen repositories in the world, with the support of the John Wayne Cancer Institute Auxiliary, The Ahmanson Foundation and the Dr. Miriam & Sheldon G. Adelson Medical Research Foundation.

Moreover, Dr. Morton possessed “an uncanny skill in shaping his ideas and visions into successful federal grants,” according to his friend, Charles M. Balch, MD, a professor of surgery at Johns Hopkins Hospital. Dr. Morton ranked among the top of all clinical/social science researchers in receiving funding from the National Institutes of Health. He often had funding for two projects at a time.

During the course of his stellar career, Dr. Morton authored nearly 1,000 scientific papers. His other significant contribution to the field was his dedication to training surgical oncologists.

Through the Institute’s surgical oncology fellowship program, he trained more than 150 fellows at the John Wayne Cancer Institute. More than 80% of those fellows have become university professors, deans or department chairs. Recently the Institute became one of the first eight programs in the country to be accredited by the Accreditation Council for Graduate Medical Education in complex general surgical oncology.

Dr. Morton will be remembered for his contributions to improving the lives of people who suffer from cancer. But he was foremost a beloved husband, father and friend. The father of four children, he often reminded his colleagues that family, friendships and collaborations were the keys to success in all aspects of life.

IN SURGICAL ONCOLOGY

Dr. Donald Morton operates with his colleague Dr. Mark Faries.


VISIONARY

When first introduced to Dr. Morton, Melinda Wayne Muñoz says she was prepared to meet a different type of man. His reputation as an academician, researcher and surgeon had preceded that meeting. But the man she met

exuded great humility and sincerity.“His compassion for his patients alongside his passion for medicine

were very impressive,” says Muñoz, the daughter of John Wayne. She serves on the John Wayne Cancer Institute Auxiliary board of directors.

Dr. Morton was unusual among researchers of his stature because he made a point of getting out of the lab to spend time with patients. “He said, ‘We don’t cure rats. We cure human beings,’” she recalls.

Dr. Morton was able to explain cancer research to a wide variety of audiences, says Ethan Wayne, the youngest son of John Wayne. Ethan is chief executive officer of the John Wayne Cancer Foundation in Newport Beach and president of John Wayne Enterprises.

When the idea first arose to name a cancer research institute after

Dr. Morton was equally at ease with patients and donors as he was with fellow scientists.

Thousands of individuals were treated by Dr. Morton or touched by his kindness over the course of his illustrious career. A few of his patients and friends recall his humanity.

PATIENTS AND FRIENDS RECALL AN APPROACHABLE GENIUS

Lorraine Morton, Sister Maureen Craig, SCL, and

Dr. Donald L. Morton


VISIONARY

his famous patient, actor John Wayne, Dr. Morton advised the Wayne family on how to proceed. “We really relied on Dr. Morton’s guidance to help us build something that was a legacy to John Wayne,” Ethan says.

He adds that his late father would burst with pride at the research accomplishments of the Institute as well as the renowned surgical oncology fellowship program. John Wayne had an easy rapport with Dr. Morton and trusted him deeply.

“As a doctor, he was a straight shooter. He was direct. My father appreciated that,” he says. “My father understood that this was a smart guy who could make a difference to a lot of people.”

The Wayne family watched over the years as Dr. Morton pioneered new surgical oncology techniques and novel treatments for melanoma. “He is the paradigm of a research physician,” says Patrick Wayne, another son of the actor and chairman of the Institute. “Through his dedication and passion, he reached a position of excellence unmatched by any of his peers.”

Dr. Morton possessed a confidence and calm that lifted up everyone around him, says Sister Marie Madeleine Shonka, SCL, the former president and chief executive of Saint John’s Health Center. “I knew him as a very spiritual person. When he suggested we should take the ‘leap of faith,’ the move of the John Wayne Cancer Institute to Saint John’s Health Center was sealed. It was a providential venture for both of our institutions.”

Sister Maureen Craig, SCL, became close friends with Dr. Morton over their many years working together at the John Wayne Cancer Institute at Saint John’s Health Center and was always impressed by his desire to see others succeed. She recalls sitting next to Dr. Morton at an annual Saint John’s Health Center Foundation trustee event in Ojai and listening to the Institute’s fellows make their scientific presentations.

“Dr. Morton kept saying, ‘Sister, isn’t this great? The cure for cancer could be in this room. Golly, I’m so proud of them,’” she recalls, smiling.

“He had this wonderful enthusiasm for what lay ahead in the hands of these young researchers.”

Dr. Morton delighted in scientific discovery, she notes. “He had a passion for research. He was devoted to it. But he drew a connection between research and people. He always asked, ‘How will this research help people?’”

Patients who sought him out at the John Wayne Cancer Institute found a man who gave them time, attention and compassion. Elizabeth Riedel, who lives in Santa Fe, New Mexico, credits Dr. Morton with saving her life after a diagnosis of melanoma on her eyebrow.

Riedel recalls Dr. Morton urging her to stay positive. During an appointment, he brought in his team to discuss the

treatment plan, which included removing the tumor while carefully sparing important facial nerves and sensitive structures in the face, such as the salivary glands. He told Riedel: “We’re going to give you half a facelift.”

“They laughed,” she recalls of the moment. “This cheered me up.” Seventeen years later, Riedel is grateful she was referred to the John Wayne Cancer Institute. “Dr. Morton saved my life,” she says.

Marte Franklin of central California, often thinks about the care that spared her son’s life about 18 years ago. Her son, Mark, was living in Portland when he was diagnosed with a rare form of malignant melanoma. He had tumors in his lungs, liver and near his kidney, and his Portland physician suggested he would survive only about three

months. A family member searched the country for a top expert in melanoma and found Dr. Morton.

“Dr. Morton told Mark he didn’t know exactly what could cure it or if it could be cured, but that he would do everything he could,” Franklin recalls.

Once Mark arrived at the Institute, he underwent chemotherapy and then surgery. He was declared cancer-free one year later and has been in good health since.

Mark’s successful treatment inspired Marte to become an annual fund donor and a member of the Guardians of the Future, the legacy society that recognizes friends and patrons who have remembered the Institute in their estate plans. “Dr. Morton gave me back my son,” she says.

Another former patient, Patricia Elton, was motivated to volunteer with the Institute after

Dr. Morton treated her for breast cancer at age 63. She remembers a doctor who understood how cancer terrified his patients.

Today she is cancer-free and enjoys spending time with her three grandchildren. She is a member of the Institute’s Auxiliary and a recent recipient of the Auxiliary’s Angel Award.

“It’s a good life lesson for my grandchildren to see that their grandmother contributes to help a man and an organization that has dedicated their very existence to saving the lives of others,” she says.

Dr. Morton kept saying, ‘Sister, isn’t this great? The cure for cancer could be in this room. Golly, I’m so proud of them.’ He had this wonderful enthusiasm for what lay ahead in the hands of these young researchers.”

—Sister Maureen Craig, SCL

Dr. Morton and his family celebrate his 2011 Spirit of Saint John's Award.


VISIONARY

“Many of the Israeli Society of Surgical Oncology benefited from the privilege of knowing Dr. Morton as a mentor, collaborator, supporter, friend, but above all as an iconic role model in surgical oncology and melanoma and a ‘mensch’—a real good man. Donald Morton left a huge impact in melanoma and surgical oncology worldwide, and many of his students and fellows who serve now as leaders will continue his legacy, his way and remember his name and contributions.” — Joseph M. Klausner, MD, professor and

chairman of surgery, Tel Aviv Sourasky Medical Center

“We all have lost a shining example of a dedicated physician and of a patient-oriented scientist, and many of us have also lost a true friend. But Don Morton has already now a lasting place in the global history of medicine because of his unique personality, his enormous work for the benefit of so many cancer patients and for the advances in surgical oncology. All this should stimulate us to follow his example.”

— Hans Starz, MD, professor of dermatology, University of Munich and

Klinikum, Augsburg, Germany

“He always stressed that the success of his research efforts were only possible through the contributions, friendship and collaboration of other dedicated people like yourselves who shared his vision. Perhaps he was most proud of the success and contributions of those he had trained. He lives on not only in the breakthroughs he authored but also through the spirit and tenacity that his example bestowed upon the many people he has mentored. I will be forever grateful for the privilege of having worked with him and being entrusted by him to help ensure that his work will be completed.”

— Mark B. Faries, MD, director of the surgical oncology fellowship program,

director of the Donald L. Morton, MD, Melanoma Research Program and therapeutic

immunology, John Wayne Cancer Institute

“I remember flying back from a cancer conference. Dr. Morton upgraded me to first class, and I sat next to him for the flight back. I was a bit anxious about what I could find to talk to the boss about for so long, but it was an absolutely pleasant time as he shared about his early childhood and family. He comes from pretty rough beginnings. I was amazed at how engaging and open he was to a mere fellow. A few years later, he took care of my mother when she had cancer, and I will never forget how generous and gracious he was to us all. In all he did, he set a very high standard without being condescending or demeaning. He believed in people and brought the best out of them. I am certain that, on some level, many of us are still working to make him proud.”

— David Euhus, MD, chief of breast surgery section, professor of surgery (PAR), Johns Hopkins

Hospital/University

“When I tell patients that I trained under Dr. Morton and his colleagues at the John Wayne Cancer Institute, there is a palpable sense of relief in their faces and a feeling of trust that they will receive exceptional care.”

— Dean Nora, MD, director, breast center, Kaiser Permanente, Woodland Hills, California; surgical oncologist; former fellow under Dr. Morton

“Don’s passing has had the same devastating impact as the loss of a close family member. He was truly an amazing clinical scientist. Like so many others, I was profoundly sad to hear of his passing but have no doubt that his many great achievements will always be remembered.”

— John Thompson, MD, executive director, Melanoma Institute Australia; professor of

melanoma and surgical oncology, University of Sydney

“Don was one of my few extra-institutional mentors. He always was a source of wisdom and encouragement to me in my ongoing aspirations to be a contributing surgeon-scientist. A wonderful, warm, positive human being. Appropriately irreverent of authority when not used for the good of the whole. Someone who would not back down from what he believed but would be transparent when something did not work out as anticipated. He was one of my heroes, and I will miss him dearly.”

— Raphael Pollock, MD, chief of surgical oncology, Arthur James Cancer Hospital, Ohio State

University Medical Center

Dr. Morton’s colleagues remember

A LEADER LOST


VISIONARY

“He was my first mentor in surgical oncology; he was for so many people. He was always generous with his time and willing to help young, academic surgeons launch their careers by showing them how he had organized his career and academic programs.”

— Charles M. Balch, MD, professor of surgery, Johns Hopkins Hospital

“His patients loved him and truly trusted him to be their steadfast ally in their fight against melanoma. He was a kind soul, a mentor to many current leaders, and a respected and cherished friend to all in the field. He will be greatly missed, but his legacy of scientific accomplishments, patient care and personal relationships will clearly endure.”

— Michael B. Atkins, MD, deputy director, Georgetown-Lombardi Comprehensive Cancer Center,

Washington, D.C.

“The melanoma and surgical community in Melbourne ... all knew Don as a great surgeon and scientist, but my memories were of a delightful colleague with a sense of humor.”

— Michael A Henderson, MBBS, BMedSc, MD, FRACS, professor of

surgery, division of cancer surgery, Peter MacCallum Cancer Centre,

East Melbourne, Australia

“Beyond his towering, seminal, professional achievements, products of his extraordinary intellect, his unquenchable curiosity and his indomitable persistence, he was an incredibly gentle, beneficent, noble man who helped all of us to be better than we could have been without him. His legacy will live on forever.”

— Dan Coit, MD, chief of melanoma surgery, Memorial Sloan Kettering

Cancer Center, New York, NY

“He was always optimistic about the outcome of either patients or research. In the research world, writing research grants and publications can be very, very challenging. But the word rejection never existed in his vocabulary. He saw rejection as an opportunity of making something better. He had this incredible way of telling his students not to despair or be discouraged but to just try harder the next time. His favorite word was tenacity.”

— Anton J. Bilchik, MD, PhD, chief of medicine and gastrointestinal research, John Wayne Cancer Institute

“Don was the staunchest of friends, a fine surgeon, a man of great wisdom, a passionate teacher, proud to be an American, but also keenly aware of his Scottish roots. He was, above all, a loving husband and father to his dear family and a surrogate parent to all the young men and women of his large surgical and scientific family.”

— Alistair Cochrane, professor, department of surgery, department of pathology and

laboratory medicine, UCLA

“Dr. Morton’s mentorship was instrumental in helping me understand and experience what a privilege it is to care for people with cancer. This intangible knowledge propels my passion and dedication to provide the best care that I can with each and every patient that I meet. I have also learned from Dr. Morton to continually seek to improve the way we practice medicine through research.”

— Connie G. Chiu, MD, complex general surgical oncology, Santa Monica, CA

The sentinel node biopsy, which was pioneered by Dr. Morton, helps doctors assess the spread of breast cancer and melanoma while minimizing surgery and side effects.

• Doctors inject a radioactive dye (blue dye) near the tumor, which illuminates the drainage pathway of the tumor and identifies the sentinel node.

• The sentinel node is then removed and analyzed by a pathologist for cancer cells.

• If cancer is found, additional lymph nodes may be removed. If the sentinel node is cancer free, the other lymph nodes are spared.

SENTINEL NODE BIOPSY


VISIONARY

The paths of two great men intersected and changed history for the better.”

—Dr. Peter Jones

Dr. Donald L. Morton saved many lives over the course of his long career, and each case was as important as the next. However, one operation in particular led to a significant

moment in history.Dr. Richard Feynman, the preeminent Caltech

theoretical physicist who won the Nobel Prize in physics in 1965, was diagnosed with cancer in 1979. A few years later, tests showed the cancer, a sarcoma, had spread around his intestines. He opted for a high-risk surgery with Dr. Morton.

Peter Jones, MD, associate professor at the John Wayne Cancer Institute and a former fellow under Dr. Morton, was at Dr. Morton’s side the day they operated on Dr. Feynman in 1981. “The tumor was so large, many surgeons would have declined to operate,” says Dr. Jones. “And providing chemotherapy alone would have likely extended Dr. Feynman’s life by only a few months.”

“Dr. Morton agreed to perform the operation knowing it was Dr. Feynman’s only option for extended survival,” Dr. Jones recalls. “The operation was 14 hours and stressful, but successful.”

On January 28, 1986, the space shuttle Challenger exploded shortly after liftoff. Honoring a request from the acting director of NASA, William Graham, Dr. Feynman agreed to serve on a presidential commission investigating the accident along with Neil Armstrong and Charles “Chuck” Yeager.

Dr. Feynman dug into the task. The pivotal moment in the investigation came on February 11, 1986, when, on national television, Dr. Feynman held up sample material of the “O-ring” rubber gasket from one of the shuttle’s solid-fuel booster rockets and dropped it into his glass of ice water. The demonstration illuminated Dr. Feynman’s

SAVING THE LIFE OF NOBEL LAUREATE PHYSICIST

DR. RICHARD FEYNMAN

theory that the gasket lost resiliency at freezing temperatures—thus allowing gases to escape and the shuttle to explode.

Dr. Feynman died on February 15, 1988, having enjoyed many years of life since that day when Dr. Morton stepped into the operating room and did his best to treat the great physicist.

“Thanks to the surgery, Dr. Feynman went on to live seven more years and solve the Challenger mystery,” says Dr. Jones. “Dr. Morton and Dr. Feynman were both pioneers and pushed the limits of knowledge in their respective fields.”

Dr. Richard Feynman solved the Challenger mystery following life-

saving surgery by Dr. Morton.


VISIONARY

With the groundwork laid by Dr. Morton, the Institute is poised to

impact cancer treatment and research for years to come.

MARK B. FARIES, MDDirector of the complex general surgical

oncology fellowship program,Director of the Donald L. Morton, MD,

Melanoma Research Program

“There is so much Dr. Morton imparted to me and everyone else during his career,” Dr. Mark Faries says. “One important thing was his ability to bring out the best in other people.”

Dr. Faries is spearheading promising research on “adoptive immunotherapy.” The approach is to develop personalized cancer treatments using immune cells taken from a patient’s tumor. The tissue sample is incubated in special cultures that enhance the growth of cancer-fighting white blood cells.

Scientists identify and select the cells that kill the malignant tumors—called tumor-infiltrating lymphocytes (TILs)—and then make billions of copies of those cells, which are injected back into the patient. The treatment revs up the patient’s immune system to fight the cancer. Such cutting-edge work is typically only possible in major cancer research centers like the John Wayne Cancer Institute, which is a recognized leader in immunotherapy.

Dr. Faries is also advancing one of the Institute’s major recent accomplishments: the publication of the results of the Multicenter Selective Lymphadenectomy Trial (MSLT-I), which validated the benefits of sentinel node biopsy in melanoma patients. In addition, Dr. Faries oversees the Multicenter Selective Lymphadenectomy Trial II (MSLT-II), which will examine what happens when the remaining lymph nodes in the area of the sentinel lymph node are removed following a positive sentinel node biopsy. The MSLT-II trial

THEPATH AHEAD

continued on page 26

From left: Dr. Dave S.B. Hoon, Dr. Delphine J. Lee and Dr. Mark B. Faries


VISIONARY

DELPHINE J. LEE, MD, PHD

Director of the Dirks/Dougherty Laboratory for Cancer Research in

the department of translational immunology

As a dermatologist, Dr. Delphine Lee began studying the skin disease leprosy early in her career. She was intrigued by the fact that the immune systems of some patients spontaneously limit the infection while others have disease that spreads. What was it about the immune system of each individual patient that could produce the varying responses? When she met Dr. Morton, he convinced her that her research would advance the work underway at the Institute.

Leprosy is caused by a type of bacteria called mycobacteria. At the Institute, Dr. Morton and his team used a type of mycobacterium called myobacterium bovis BCG to boost immunity in cancer patients, an idea he first developed while working at the National Cancer Institute and treating a woman with a particularly challenging case of advanced melanoma. At the John Wayne Cancer Institute, he and his team found that administering doses of BCG seems to stimulate the immune system to fight the cancer.

“When Dr. Morton told me about the use of Bacillus Calmette-Guérin, I was dumbfounded,” Dr. Lee recalls. “He said, ‘We don’t know how this works.’ And I thought, ‘This is what I want to

study—understanding the way BCG helps us fight cancer could lead to new therapies.’”

Dr. Lee has established two major cancer research avenues in the Dirks/Dougherty Laboratory for Cancer Research at the Institute: understanding how the immune system fights cancer and how to use bacteria, such as BCG to enhance the immune response. While cancer vaccines have proved to be challenging, the latest approach—immunotherapy—involves prompting a stronger immune response to fight cancer.

Dr. Lee’s research is augmented by the extraordinary blood and tissue repository, which provides patient samples from

decades ago. “It’s an immunologist’s dream to

study the blood of cancer patients and compare the ones who survive for years to those who don’t,” Dr. Lee explains. “I really don’t think there is a collection of

immune cells like that anywhere else.”“Now we’re seeing the emergence of effective new therapies. And

that is reinvigorating studies in immunotherapy,” she says, adding that immunotherapy, the specimen repository and the Institute’s ability to draw in many collaborators to work on complex problems in oncology are hallmarks of the Institute.

“We have a great team,” the doctor explains. “If we pool all of our vast differences of expertise, both clinically and scientifically, with our patient population and our ability to collect specimens and history from our patients, we are really unstoppable. Every piece of the machine is here.”

+ Dr. Lee’s research receives generous support from the Associates for Breast and Prostate Cancer Studies (ABCs), the Avon Foundation, the Carolyn Dirks and Brett Dougherty/Joseph B. Gould Foundation and NIH grants.

has already reached its planned enrollment of more than 4,000 patients around the world.Moreover, Dr. Faries is conducting a clinical trial that will assess the use of minimally invasive

surgical techniques for removing lymph nodes in cancer patients. The research in his lab reflects what he views as the uncommon strengths of the Institute.

“The Institute has always had this unique mix of characteristics of a big institution and a small institution. That mix is something you don’t see anywhere else. We can lead multi-center trials, such as the MSLT trials. At the same time, we still have a tight-knit, small, efficient group of researchers here. That makes us nimble and more flexible. It improves our ability to collaborate, to do things outside of the traditional silos of a university environment.”

MARK B. FARIES, MD continued from page 25

Dr. Morton was honored in April with the posthumous awarding of the Medallion for the Advancement of Surgical Care. The elite honor was bestowed by the American Surgical Association, which noted that the Medallion is “given on rare occasions to a surgeon who has made seminal contributions over his/

her career that have advanced clinical surgery and surgical education and established new paradigms in surgery. The recipient shall have made innovative and lasting contributions to the advancement of care to the surgical patient.” The ASA is the nation’s oldest and most prestigious surgical organization.

AN HONOR FROM HIS COLLEAGUES


VISIONARY

DAVE S.B. HOON, MSC, PHD

Director of molecular oncology

Chief of scientific intelligence

Director of the genome sequencing center

Dr. Dave Hoon recalls many discussions in which Dr. Morton urged his colleagues to focus on translational research that may open opportunities in improving cancer diagnosis and treatment. That is the focus in the department of molecular oncology.

“One of Dr. Morton’s big influences on me was in translational research,” he says. “He was doing this back in the ‘70s. When I started doing molecular studies, he encouraged me to focus on monitoring patients molecularly for responses to treatment in melanoma. He was a strong supporter of these programs and new approaches using molecular genetics. This led to significant, fruitful collaborations with Dr. Morton that produced publications in high-impact journals as well as multiple, major National Institutes of Health funding on projects from 1986 to the present.”

The result of that advice is now fully evident. Dr. Hoon and his colleagues have pioneered the study of assessing circulating tumor cells and circulating DNA to improve diagnosis and patient monitoring.

There are several areas of genetic and molecular research

in Dr. Hoon’s laboratory. He identifies tumor cells that are circulating in a patient’s blood and can use information gleaned from those cells to predict patient responses to a particular treatment. He can also identify circulating tumor-related DNA in the bloodstream that may be useful in monitoring a patient’s response to treatment.

Another approach involves analysis of how the tumor changes during progression over time—epigenetic (modified genomic DNA) changes that reflect the characteristics of the

tumor as it evolves from a small growth to tumors that may be spreading to other areas of the body. Finally, Dr. Hoon’s group is studying the epigenetic

properties of metastatic brain cancers to help identify which patients are at highest risk of developing metastasis.

Under the new sponsorship of Providence Health & Services, Southern California, the John Wayne Cancer Institute has enormous potential to grow, Dr. Hoon says. “We’ve gone through many changes in the last several years, but this is a new and exciting time with Providence, which allows us to be part of a very strong and dynamic organization. They have experience with and a firm understanding of cancer programs.”

The Institute, however, will be able to maintain its core identity and visionary leadership in cancer research. “The Institute is unique because it combines clinical and laboratory research and focuses on making it as seamless as possible,” Dr. Hoon says. “Others have tried to copy it, and it’s difficult.”

The board of the John Wayne Cancer Institute has named the world-renowned melanoma research program in honor of Donald L. Morton, MD. Dr. Morton dedicated his career to improving the lives of patients with melanoma. In this effort, he was more successful than perhaps anyone in history, and his contributions will continue to benefit patients for generations.

With the naming of the Donald L. Morton, MD, Melanoma Research Program, the board is honoring the memory of one of the Institute’s amazing founders. This program will advance Dr. Morton’s values so the work he started may be preserved and extended into the future. The program

will focus on the three issues that were most important to Dr. Morton throughout his career: the education of young surgeon-scientists, the use and improvement of surgery as a treatment for cancer and immunotherapy.

While it’s impossible to repay the enormous debt owed to such a great individual, the Institute board hopes that by carrying on the work Dr. Morton held so dearly, it can honor his memory and preserve his legacy. To learn more about supporting the lifesaving cancer research at the Donald L. Morton, MD, Melanoma Research Program, call the John Wayne Cancer Institute development office at 310-315-6111.

THE DONALD L. MORTON, MD, MELANOMA RESEARCH PROGRAM

+ Dr. Hoon’s research receives generous support from the Dr. Miriam & Sheldon G. Adelson Medical Research Foundation, the Associates for Breast and Prostate Cancer Studies (ABCs), the Ruth and Martin H. Weil Fund and NIH/NCI grants.


MEMORABLE EVENTS

JWCI Auxiliary Odyssey Ball

The 29th Annual John Wayne Cancer Institute Auxiliary Odyssey Ball was held on Saturday, April 5, at the Beverly Wilshire. Anton J. Bilchik, MD, PhD, chief of medicine at the John Wayne Cancer Institute, was honored with “The Duke” Special Service Award, presented by his son. Dean Bilchik observed that the award “is given to an individual who has shown themselves to not only be a champion in the fight against cancer but also to someone with a social conscience.” Nelson Mandela’s granddaughters and global human rights advocates HRH Zaziwe Dlamini-Manaway and HRH Zamaswazi Dlamini represented the Mandela family as they accepted the “True Grit” Humanitarian Award. The princesses noted: “We leave you with our grandfather’s last words when he was stepping down from office: ‘It is in your hands.’ It is upon all of us in this room to make sure that we honor both Nelson Mandela and John Wayne legacies to find a cure for this disease.”

JWCI Auxiliary board members Susan Veerman and Cynde Wilen co-chaired the event under the leadership of Auxiliary president and John Wayne’s granddaughter, Anita Swift. This year’s fundraising was led by the generous support of our sponsors: Odyssey Sponsors—Dr. Miriam and Sheldon Adelson; Visionary Sponsors—the Wayne family; and Platinum Patrons—Suzanne and Rob Davidow, Gayle and Marc Ezralow, Providence Health & Services, Wells Fargo, and the Carole Zumbro and George Adler family. Actor, motivational speaker and U.S. Army veteran J.R. Martinez emceed the evening, and Broadway legend Davis Gaines performed.

Karen Weil, Alan Weil

Lewis Wallensky, Hollace Brown, Patrick Wayne

Mark Dyne, Wendi Dyne

Howard Banchik, Jackie Banchik

Annick Brunaud, Patrick Infante

Cynde Wilen, Patrick Wayne, Susan Veerman

Richard Bry,Sheldon Adelson

Dr. Anton Bilchik, Nadia Bilchik Kesler

Patrick Wayne, Melinda Wayne Muñoz

Dean Bilchik

Patrick Wayne, HRH Zamaswazi Dlamini, Dr. Anton Bilchik, HRH

Zaziwe Dlamini-Manaway

Anita Swift

Shirley Lipstone, Ruth Weil, Ilene Eisenberg, Jackie Banchik, Hollace Brown, Diane Feldman

Jeff Worthe, Kristin Worthe, Gayle Ezralow, Marc Ezralow


MEMORABLE EVENTS

We leave you with our grandfather’s last words when he was stepping down from office: ‘It is in your hands.’ It is upon all of us in this room to make sure that we honor both Nelson Mandela and John Wayne legacies to find a cure for this disease.”

—HRH Zaziwe Dlamini-Manaway & HRH Zamaswazi Dlamini

Dr. Anton Bilchik, HRH Zaziwe Dlamini-Manaway, HRH Zamaswazi Dlamini, Anita Swift, Patrick Wayne

Danielle Morton, Lorraine Morton, Dr. Miriam Adelson

Dr. Anton Bilchik, Norma Bilchik, Dr. Miriam Adelson, Sheldon Adelson

Dr. Elizabeth Arena, Dr. Victoria O’Connor, Dr. Simon Lavotshkin, Ruth Weil, Dr. Gary Deutsch

Dr. Anton Bilchik, Joyce Eisenberg Keefer

Suzanne Davidow, Robert Davidow

Dr. John Robertson, Michael Wall

Ethan Wayne

J.R. Martinez (evening host)Dr. Cara Natterson, Dr. Paul Natterson

Dr. Chester Griffiths, Dr. Daniel Kelly

Davis Gaines (special performer)

Gerard DiNome, Dr. Maggie DiNome

HRH Zaziwe Dlamini-Manaway, Dr. Anton Bilchik, HRH Zamaswazi Dlamini

Dr. Delphine Lee, Patrick Loo

Patrick Wayne, Nadia Bilchik Kesler

James Saletnik, Dr. Maureen Chung

Joyce Eisenberg Keefer, Joyce Green, Ruth Weil

Dr. Lawrence Piro, Judy Piro


MEMORABLE EVENTS

John Gebbia, Gloria GebbiaNicole Faries, Dr. Mark Faries

Ilene Eisenberg and familyMarisa Wayne

Shane Bush, Melanie Wayne Bush

Roberta Novick, Martin Gardner

The Wayne familyRoger Wacker, Angelle Wacker

Jillian Lipstone, Shirley Lipstone, Susan Veerman, Jordan Friedberg, Janine Gershon Friedberg

Barbara Tfank, Peter Markham,David Baird, Tracy Baird

Brynie Silver, Steven Silver, Steve Kesler, Brian Bilchik

Emilio Arechaederra, Maria Arechaederra

Mary Kay Wolf, Raouf Boudjakdji

Toby Waldorf, Robert Waldorf

Anita Swift, HRH Zaziwe Dlamini-Manaway, HRH Zamaswazi Dlamini, J.R. Martinez

Dr. Anton Bilchik, Norma Bilchik,

Dean Bilchik

David Manaway, HRH Zaziwe Dlamini-Manaway, Sheldon Adelson, HRH Zamaswazi Dlamini,

Keith Grandberry

Back Row: Katie Lewis, Marisol Zarco, Michael Wayne, Terry Curtin, Jody Pritchard, Merritt Loughran, Peggy Moretti, Jessica Royer Front Row: Mona Horton, Anne Marie Scibelli, Kathleen Duncan, Andrea Zuckerman, Colleen Pennell

Michael Hunn, Michael Wall

Leonard Ross, Nadia Bilchik Kesler, Dr. Miriam Adelson


MEMORABLE EVENTS

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Providence Saint John’s Fundraiser for New Breast Center Yoga ProgramMaggie DiNome, MD, medical director of the Cancer Prevention Clinic at the Margie Petersen Breast Center at Providence Saint John’s Health Center, hosted a fundraising yoga class and luncheon with actress Kate Beckinsale at the home of Saint John’s Health Center Foundation trustee Mary Flaherty. The event, attended by artist P!nk, celebrity fitness expert Jeanette Jenkins and yoga instructor and author Mandy Ingber, successfully raised funds to launch a new yoga program for patients undergoing breast cancer treatment and those at high-risk for developing the disease.

1. Kate Beckinsale 2. Dr. Maggie DiNome, Kate Beckinsale, P!nk 3. P!nk doing warrior pose 4. Event guests participate in yoga led by Mandy Ingber. 5. Mary Flaherty, Kate Beckinsale, Dr. Maggie DiNome 6. Mandy Ingber, Kamla Subramanian, Dr. Maggie DiNome, Kate Beckinsale, Michael Wall, P!nk, Jeanette Jenkins, Dr. Maureen Chung, Mary Flaherty

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MEMORABLE EVENTS

Benefactors DinnerJohn Wayne Cancer Institute honored its major supporters at the 2013 Benefactors Dinner at the Four Season Hotel in Los Angeles on December 8, 2013. Benefactors who support innovative cancer research at the highest levels of giving were recognized for their consistent and valued generosity by the Institute’s leadership and the Wayne family. Highlights of the evening included research updates from the Institute’s chief of medicine, Anton J. Bilchik, MD, PhD, and comments from the fellows who shared their personal stories about what brought them to the Institute.

Michael Wall, Barbara Wall, Michael Hunn, Patrick Wayne, Brenda Surowitz, Dale Surowitz Seymour Rosenblum, Sheri Rosenblum

Ilene Eisenberg, Dr. Anton Bilchik, Lois Rosen

Shane Bush, Melanie Wayne Bush, Patrick Wayne, Marisa

Wayne, Anthony Ditteaux, Michael Wayne

Michael Wayne, Laura Coats, Patrick Wayne, Thom Schulz

Anita Swift, Patrick Wayne, Martha HarperJohn Gebbia, Gloria Gebbia, Patrick Wayne, Anita Swift, Michael Wayne Michael Wayne, Christine Wayne

Michael Wayne, Victoria Murray, Carl Murray, Martha Doornink, Ronald Doornink, Roberta Novick, Patrick Wayne

Jill Robertson, Dr. John Robertson, Donna Tuttle, Michael Hunn

Howard Banchik, Jackie Banchik, Patrick Wayne

Mel Keefer, Joyce Green, Joyce

Eisenberg Keefer, Patrick Wayne


MEMORABLE EVENTS

Susan Veerman, Richard Veerman, Ruth Weil, Marisol Zarco

Anita Swift, James Saletnik, Hollace Brown, Dr. Maureen Chung

Dr. Delphine Lee, Thom Schulz, Laura Coats, Patrick Loo

Dr. Michael Sigman, Dr. Nefertiti Brown ( JWCI Auxiliary breast fellow), Ruth Weil, Dr. Joslyn Albright (Tarble Foundation fellow), Dr. Victoria O'Connor (The Harold McAlister Charitable Foundation fellow), Ryan O'Connor

Ronald Ross, Danielle Brown Ross, Patrick Wayne

Danny Feldman, Diane Feldman, Patrick Wayne

Thank-you gifts for benefactorsHollace Brown and Lewis Wallensky

Carlye Morgan, Michael Morgan

Rick Lewis, Katie Lewis, Victoria Murray, Carl Murray Sister Maureen Craig

Dr. Anton Bilchik, Norma Bilchik, Michael Wayne

Martha Doornink, Ronald Doornink

Lisa Greenberg, Marty Greenberg

Ruth Weil, Dr. Simon Lavotshkin

Alan Borstein, Brenda Borstein

Dr. Maureen Chung, James Saletnik, Dr. Nefertiti Brown

Jackie Banchik, Dr. Frederick Singer, Sandra Singer

Deborah McIntosh, Michael Caan

Joan Berlin Reeder, Stephen Reeder

Dr. Victoria O'Connor


MEMORABLE EVENTS

JWCI faculty and guests Top Row (from left): Dr. Laurent Lessard, Dr. Nancy McLaughlin, Dr. Maggie DiNome, Gerard DiNome, Dr. Delphine Lee, Patrick Loo Bottom Row (from left): Dr. Roderick Turner, Michele Turner, Dr. Mark Faries, Nicole Faries

ABCs “Talk of the Town”The Associates for Breast and Prostate Cancer Studies (ABCs) hosted its 24th annual star-studded, black-tie event at the Beverly Hilton Hotel on November 23, 2013. Proceeds benefited breast and prostate cancer research at the Institute. Patrick Wayne presented actress Ann-Margret with the Spirit of Entertainment Award. Actor and Saint John’s Health Center Foundation trustee Robert Wagner was honored with the Spirit of Hollywood Award, and business leaders and community advocates Bill Patterson and Roseann Patterson accepted the Spirit of Hope Award. ABCs president Gloria Gebbia and vice president Sheri Rosenblum co-chaired. Actress and comedian Kym Whitley hosted, and award-winning R&B legends The O’Jays gave an energetic performance that brought guests to their feet. To date, the ABCs have raised more than $14 million to support breast and prostate cancer research at the Institute.

Robert Wagner, Ann-Margret, Roseann Patterson, Bill Patterson, Patrick Wayne

Robert Wagner, Gloria Gebbia, Patrick Wayne, Donna Tuttle

Carlton Gebbia, David Gebbia

Patrick Wayne, Ann-Margret, Michael Wayne

Special performance by The O’Jays


MEMORABLE EVENTS

Robert Wagner, Sister Maureen Craig

Marty Greenberg, Lisa Greenberg

Chad Michael Murray, Nicky Whelan

Kym Whitley, Mike Epps

Jerome “Pooh” Richardson

Roseann and Bill Patterson

John Gebbia, Gloria Gebbia Beverly Cohen, Robert Cohen

Michael Wall, Patrick Wayne, Gloria Gebbia, Robert Wagner

Seymour Rosenblum, Sheri Rosenblum, Dr. Craig Rosenblum

Jill Oakes, Jordan Farmar


MEMORABLE EVENTS

JWCI Auxiliary LuncheonThe John Wayne Cancer Institute Auxiliary honored Patricia Elton with the Angel Award and Susan Love, MD, MBA, with the Public Service Award at their Annual Membership Luncheon and Holiday Boutique on October 17, 2013, at the Beverly Hills Hotel. After receiving her award from Institute chairman Patrick Wayne, Patricia Elton, a breast cancer survivor and long-time supporter of the Institute, recalled with gratitude the lifesaving treatment she received from Donald L. Morton, MD. Delphine Lee, MD, PhD, director of translational immunology at the Dirks/Dougherty Laboratory for Cancer Research, presented Dr. Love with an award for her dedication to eradicate breast cancer. Katie Lewis and Marisol Zarco co-chaired the event, and actor/writer/producer Gerard DiNome emceed.

Transition CeremonyIn February, Providence Health & Services, Southern California, and the founders of Saint John’s Health Center, Sisters of Charity of Leavenworth, held a moving ceremony to commemorate our sponsorship transition. Institute researchers, donors and board members were in attendance along with Saint John’s leadership and physicians to bid farewell to our previous sponsors and welcome in the new.

Patricia Elton accepts the Angel Award.

Dr. Marilou Terpenning, Dr. Susan Love, Dr. Delphine Lee, Dr. Maggie DiNome, Dr. Maureen Chung

Martha Harper, Michael Wall, Dr. Anton Bilchik, Patrick Wayne, Anita Swift

Michael Wayne, Dr. Mark Faries, Ruth Weil, Dr. Delphine Lee

Dr. Daniel Kelly, Dr. Anton Bilchik, Dr. Marilou Terpenning

Katie Lewis, Patricia Elton, Dr. Susan Love, Marisol Zarco

Auxiliary past presidents Top Row (from left): Ruth Weil, Hollace Brown, Anita Swift, Lois Rosen, Ilene Eisenberg, Bottow Row (from left): Roberta Novick, Jackie Banchik, Shirley Lipstone

Gerard DiNome, Patrick Wayne


MEMORABLE EVENTS

Jackie Banchik, Danny Feldman, Diane Feldman

Dr. John Robertson, Tonian Hohberg, Pat Epstein, Jerry EpsteinSister Maureen Craig, SCL; Brett Dougherty, Carolyn Dirks

Co-chairs: Allan B. Goldman, Dr. Sophie Andriaschuk, Ruth Weil, Dr. Rob Amonic

Michael Hunn of Providence Addresses First Board of Advocates MeetingIn early March, the Riviera Country Club George Thomas Room was filled to capacity with friends of the John Wayne Cancer Institute and Providence Saint John’s Health Center, eager to hear the latest Institute and Health Center news and get to know Providence Health & Services’ senior vice president and regional chief executive, Michael Hunn. Previously known as the Board of Counselors, the newly named Board of Advocates is a select group of trustees, friends and patrons who help further the missions of our two institutions and serve as ambassadors to the community. Guided by their four new co-chairs, Allan B. Goldman, Dr. Sophie Andriashuck, Ruth Weil and Dr. Robert Amonic, the board plans to meet biannually as well as hold a summer social event.

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1. Marisol Zarco, Elizabeth Rawjee, Colleen Pennell, Dr. Delphine Lee, Dr. Susan Love, Sonya Rosenfeld, Jessica Royer, Katie Lewis 2. Dr. Delphine Lee, Michael Wall, Dr. Susan Love 3. Dr. Love addresses group

Dr. Lee and Dr. Love Fundraising EventIn February, the John Wayne Cancer Institute Auxiliary hosted a salon conversation with Delphine Lee, MD, PhD, and Susan Love, MD, MBA, to benefit breast cancer research at the John Wayne Cancer Institute and the Dr. Susan Love Research Foundation. Together, Dr. Lee’s team at the Institute and the Dr. Susan Love Research Foundation are exploring the possibility that breast cancer development could be influenced by a bacteria or virus. The clinical impact of this study could lead to major improvements in treatment through the development of highly innovative therapies for breast cancer, such as utilizing probiotics in treatment and prevention, or using bacteria to help assess the severity of disease. Dr. Lee’s initial study was made possible by a grant of $300,000 from the Avon Foundation for Women.


DIAMOND CIRCLE ($500,000+)Sally Anne BurgeMargie and Robert E.

Petersen FoundationDr. Miriam & Sheldon G. Adelson

Medical Research FoundationMickey and Bud Erhardt

YELLOW SAPPHIRE CIRCLE ($250,000+)The Fashion Footwear Charitable

Foundation of New YorkJohn Wayne Cancer

Institute Auxiliary

EMERALD CIRCLE ($100,000+)The Carole Zumbro and George

Adler FamilyAssociates for Breast and Prostate

Cancer Studies Inc. (ABCs)Avon Foundation for WomenThe Harold McAlister

Charitable FoundationJohn Wayne Cancer FoundationRuth Weil

RUBY CIRCLE ($50,000+)Patricia C. Brown FoundationJohn E. ConnerThe Carol and Barry Kaye

Charitable FoundationAlice and Verne McKinneyThe Lois Rosen FamilyRoy E. Coats Memorial Fund/

Laura Coats and Thom Schulz

BLUE SAPPHIRE CIRCLE ($25,000+)Robyn and Michael AltmanJoan Berlin ReederBorstein Family FoundationDanielle Brown Ross and

Ronald RossThe Davidow Charitable FundEntertainment Industry

FoundationEstate of Claude E. Gainer and

Thelma J. GainerMcCormick Family TrustDonna J. MettlerMr. and Mrs. Jeffrey SchwartzSandra and Frederick Singer

PLATINUM BENEFACTORS ($10,000+)Jackie and Howard BanchikFrank E. BaxterBingham McCutchen’sGracia Bremer

Charitable FoundationGerald BronsteinDr. Tandra and

Dr. Patrick CadiganNeal and Karen DemIlene EisenbergPatricia A. EltonRoberta and Robert FeldmanLeon and Toby Gold FoundationThe Bob & Gaye Harris FoundationRuth G. JervisLinda Tallen and David Paul Kane

Cancer Education and Research Foundation

Mrs. Hildegard T. KnollMeningioma MommasVictoria and Carl MurrayMrs. Marguerite Perkins MautnerLinda Bernstein Rubin and

Tony RubinSusan and Henry SamueliMichael SannesNancy and Michael S. SitrickJacquelyn and Larry StephensonSurf City Tourneys, Inc.Sandra and Robert TeitsworthAudrey J. Walton and Ann Walton

Kroenke Charitable Foundation

Beti WardMrs. Kimberly Harris and

Mr. Scott WeinerMary Ann and Marvin WeissRobert and Joan Zukin

GOLD BENEFACTORS ($5,000+)America’s CharitiesMaria and Emilio ArechaederraTimothy Aycock Melanoma

Research FoundationThe Solomon R. and Rebecca D.

Baker FoundationNorma M. BakerJannell and Randy BanchikThe Boudjakdji FoundationHollace Brown and

Lewis WallenskyBat-Ami and Gerald CohenJulie CollinsWendi C. EisenbergDiane and Daniel FeldmanMary Frances and

Andrew J. FenadyWilliam FitzgeraldFraternal Order of EaglesFriars Charitable FoundationFrickel Trust MSSB Gift Inc.Jack R. FrickelAlain and Myra GabbayKathleen GarfieldThe Robert Garthwait FamilyMr. and Mrs. Harvey S. Gettleson

The John Wayne Cancer Institute is deeply grateful for the philanthropic support of all our donors and friends. Your generosity funds breakthrough cancer research, sparks promising new treatments and provides inspiration to our physicians, scientists and

fellows. Thank you for your partnership in our mission to eradicate cancer.

ANNUAL GIVINGThe John Wayne Cancer Institute at Providence Saint John’s Health Center is honored to recognize the following generous donors who have made an annual commitment of $250 or more between January 1, 2013, and January 31, 2014.

Honor Roll

HONOR ROLL


Jay GoffmanStanley GoldThe Gores GroupJulia and Ken GouwJames D. GrayGuggenheim Capital LLCThe Hammock Family FoundationJ. M. HenniganPhyllis L. HenniganCarolyn and Bill HolderBradley A. JabourJudianne and Kenneth JaffeTera and Jason JeraldsBlanche and George Jones

Fund, Inc.Kantor FoundationKiwanis Club of Tustin

Club No. 05103KLM FoundationDenise S. KordanSandra Krause and

William FitzgeraldThe Litt Family FoundationKathleen L. McCarthy Kostlan

and Frank KostlanSherry MillerAnn MoorefieldMike and Muffy Murphy FundRoberta NovickPayden & RygelRalph and Marcia PetersonJoe PhamPremier Girls FastpitchCarmen and Richard RogersPhilip and Monica RosenthalShea-Hurley Charitable FoundationMel and Sheryl ShermanThe Dinah Shore FoundationRalph SimonSimon-Strauss FoundationSisters of Charity of LeavenworthSkadden, Arps, Slate, Meagher &

Flom LLPLinda and Stanley TrillingNeeltje and Paul Van ElderenSusan and Richard VeermanPaige WarePeter WeilThe Winnick Family FoundationJoan R. YoungJoan and Robert YoungPaula Zeidman

BRONZE BENEFACTORS ($2,000+)Joyce and James P. AllenThe Amyx Foundation, Inc.Arleen BachnerDebbie and Doug BaronJohn R. BaroneSheri and Arthur BerkDr. Michael CaanDiane CalderVictoria and Michael J. CohenKarrie and David DeatonMr. Peter R. DunnRobert L. FlorencePatsy P. FranklinStan and Pat GoldmanBruce L. GoldsmithMadelaine and Gene GordonFrances and Daniel HamermeshBill Hannon FoundationCarol L. HaskinIn Memory of Cathy HasselbergerDonna and Mel HeierMel R. HeierMarcia W. HobbsKevin KellySusan and Miles KillochBrian KirkdofferLawrence J. KussLewis, Shirley and Jillian LipstoneBruce and Sandra MassmanMr. and Mrs. Michael MorganAlice R. NeumanThe Ronald Newburg FoundationLee and Marguerite PolsterWilliam H. Prusoff FoundationPyramid Foundation Inc.Real To Reel, Inc.Sara RisherMansel and Brenda RubensteinKretta and James ShanerIn Memory of Jim HurleySidney Stern Memorial TrustMr. and Mrs. Timothy SiegelCharles and Donna SouthardHerb and Jacque SpivakBarbara TaubJoe and Janet TydlaskaThe U. S. Charitable Gift TrustJan and Meredith VoborilSandi and Dan WalkerBarbara and Michael WallMr. and Mrs. Leonard Weil

David M. WendtR.B. Wilson Co.Carol & Robert WilsonZolla Family Foundation

ANNUAL DONORS ($1,000+)Doris AlexanderDavid C. AndersonMargot and Mark ArmbrusterDon Ayres, Jr.Lawrence C. BakerCatherine BauerIna BezahlerThe Bidstrup FoundationDeborah BowenLynn BrodyMarlene Bronson and Cliff FriedLisa Chaiken, MDDwayne R. ChurchesCommunity Foundation Serving

SW Colorado The Gabriel FundCynthia S. ConnollyJoseph ConnollyJohn R. CopelandCorcept TherapeuticsJoe Crail Western Mutual

Insurance GroupTimothy DavisGerald DinomeAdam DuncanPamela EltonMark FaberKaryl FisherDavid FradinSherman M. FranklinCliff FriedMartin GardnerCherna L. GitnickAnthony GlassmanDonna and Norman GleitNorman GleitThe Goldrich Family FoundationJona GoldrichDiane B. GoldsteinThe Haft FamilyTom J. HallOmid HamidChan HuntCarol A. HutchisonAndrew KaneMarla and Michael KantorCarole and J. T. KennoyDoreen and Kenneth Klee

David L. KrasneJanice White and

Eugene KriegerMark LaConaRichard LawtonKathleen and Rick LewisTimothy F. LewisJeff ManuppelliWyatt McCreaKathryn McFarlaneJane and Jerome MillerRaye Paul MillerGregory MilmoeRichard F. MoganJim MorrisCharles MoultonF. Dian MroskoBronwyn MurdockMr. and Mrs. Jimmy MurphyMaurice MurphyLisa NesbittCathryn and Victor PalmieriMargaret and Don QuonAdam RatnerMary C. RivaRichard SandlerSteven C. SchumannSecret Weapon MarketingMiriam and David SitrickAnsel A. SlomeNorman F. Sprague Jr. FoundationSt. Martin of Tours SchoolSymetraJohn M. TiptonLaurie A. TissotUnderhill Investment

Management LLCSusan and Richard VeermanEllen VictorMr. Robert J. VignoloToby WaldorfDiane C. Weil and Leslie HorowitzJamie and Michael WeilSharon WeilMrs. Henry P. WheelerCarl E. Wynn FoundationRichard F. ZamboniMarisol and Dominique Zarco

ANNUAL DONORS ($250+)24Hr HomecareAmmar Abu-LughodLois and Buzz Aldrin

HONOR ROLL


Mary K. AllisonJames M. AndreoliAssociates of The Cedar GroupAutoZone Matching Gift ProgramBank of America United

Way CampaignEstelle BaronMargot A. BarronKathleen E. BishopStephanie BlackmoreLisa BlonsBloomingdale’s Inc.Deborah and Carol BohnTeresa BondBeverly and George I. BoyadjieffBP America Inc.April A. BradleyJames J. BrosnahanLenore F. BroughtonBarbara K. BrownColonel and Mrs. Charles W.

Brown, USAF, RetGary D. BrownJacqueline BurdorfJanice H. BurrillCalifornia Oncology

Research InstituteCapital MechanicalDorothy M. CarterJames C. CarterWendell W. ClementsMilton L. CliftCarol and Jerome CobenSandy and Irv CohenStephen D. ComleyDavid CookeJoanne and Gerald CorneliusCarollee CourtneyCrespi MothersPierre F. CrosettoThomas C. CrouseTerry and Greg CurtinJeffrey L. DahlgrenSharon DaneDavid Cooke Plaster Co.Laura and Roger H. DavisPaul C. DeutschDavid S. DiazTate DonovanJoseph F. Dox

Glenn E. DrownJennifer EhrenpreisJennifer and Ralph EhrenpreisAnne ElmanWilliam ElperinGeorge EngelmannHarold C. EricssonLouis R. FabbianoFred A. FernIvette FernandezJames B. FisherMelanie and Richard FlamminioRobert A. FloydLynne M. FlynnDarlene FogelForest Family FoundationMyrna S. ForestCyndie C. Foster George W. FrankMartha J. FranklinJeff FreidArdyth and Samuel FreshmanJanine and Jordan FriedbergJeri A. FukumotoValarie and Evan GardnerGloria and John GebbiaGemini Basketball, LLCJanine Gershon Friedberg and

Jordan FriedbergMarilyn and Allen GoldenJoseph G. GormanGreenberg Traurig, LLPBetty L. GriffithJames M. GriffithThe Arthur & Jeanne

Hadley FoundationCarol HalperinG. P. HamatiKeith HarmonMartha and Donald HarperAndrea A. HarrowLarry HarrowJames M. HartelBarbara and Don HeinrichTami and Robert HerbeckAmbassador and

Mrs. Glen A. HoldenGeorge R. HorneLinda HowardIDS Real Estate GroupJohn IinoIndulgence, Ltd.J. Marshall Robbins FoundationMary Rose and John Jardine

Dolores H. JohnsonAndrea KatzDonald KiddSheldon M. KirschThaddeus KleszczJanisse KlotchmanBilly E. KoenigReverend James KollingKPMG Community

Giving CampaignDevin P. KramerMr. and Mrs. Harold E. LandonDonald H. LarkinTheresa and Robert LassRodney G. LaverWalter LeddaJoseph LeimbachDan M. LeonardIna and Bernard LewisWayne S. LiftonJane and Howard LipstoneWilburn H. LongBarbara and William LongStanley LucasEvelyn and Martin LutinCorey and Mary Ann LutzSteve MastersonAnn MazirowTheodore L. McCluerJeffrey McConnellDana McCormickMarcela McKennaHonorable Patrick T. MeyersCarol MichaelianDonald E. MinkoffHelene MoskowitzAnne and Peter MostAlfred A. MoursundMary P. Mueller

James C. MulhollandPhyllis NaultPhyllis NaylorLisa Niedenthal

Novick DevelopmentMichael NovickDaniel T. OakleyMisaki M. OkimotoNancy and Harrison OliffDavid M. OlsonArthur B. PachecoAnne PalamidesRuth and Mark PashJanet PaxtonColleen and Chris PennellSigrid PepperPaula L. PinhasPeter PoulsonWilliam L. PyleRCL FoundationEdward J. ReichlerMarianne ReisStephanie and Paul ReiszNancy ReskinDan S. RhodesRandolph W. RichardsonElizabeth J. RiedelJ. A. RiordanJill and John RobertsonDavid RodenKenneth J. RodgersRollGivingSylvia and Herbert RoseMary A. RoseSylvia RoseSandra D. RosenbaumSam RosenbergSheri and Seymour RosenblumRichard RothsteinJessica and Steve RoyerAda and Leonard SandsSaratoga Polo AssociationSavannah Santa Monica

SBR, Inc.Eve ScheinmanMichael G. SchmitzLeah Schneider

ANNUAL GIVING(continued from page 39)

I am only one, but I am one. I cannot do everything, but I can do something. And I will not let what I cannot do interfere with what I can do.”

—Edward Everett Hale

HONOR ROLL


Schwab Charitable FundGary L. SchwandnerAnne Marie ScibelliGary M. ShaferDoreen and John ShanerRobert ShapiroAlan SharpCarolyn ShelleyRuss ShimizuTy ShrakeAngela and John ShukittRobert M. ShumanJoy F. SiegelJames E. SimsHans E. SkacelKenneth R. SmithSharian SpencerJames D. StaleyJackie and Bob StiborCatherine A. StoneArline and Donald StroupHerbert D. SturmanGeorge TeitelbaumPatience F. TekulskyEdward B. TennisElizabeth ThamerWayne ToutgesBarbara TurnerBernard Van Tol Michael VasseghiEdward W. VernonAllison M. VoegeliAbraham WachtCharles WarnerSusan L. WeilMarla and Wade WeimanLaurie WeissSidney J. WeissWells Fargo Community

Support ProgramMarnie WickertCynthia and Mitchell WilenDiane R. WinklerSueo YamashitaGwendolyn F. YangPetrus J. ZaalAndrea Zuckerman

PAVE DIAMOND CIRCLE ($1,000,000+)Dr. Miriam & Sheldon G. Adelson

Medical Research FoundationThe Ahmanson FoundationAssociates for Breast and Prostate

Cancer Studies (ABCs)Avon Foundation for WomenDonald and Brigitte Bren in

Honor of Marion JorgensenThe Eli and Edythe L. Broad

FoundationRoy E. Coats Memorial Fund/

Laura Coats and Thom SchulzRita and Bill CoorsThe Davidow Charitable FundCarolyn Dirks and Brett

Dougherty and the Joseph B. Gould Foundation

Ben B. and Joyce E. Eisenberg Foundation

The Fashion Footwear Charitable Foundation of New York

Gloria and John GebbiaLeslie and Susan Gonda

(Goldschmied) FoundationJohn Wayne Cancer

Institute AuxiliaryJohn Wayne Enterprises Marion and Earle M. JorgensenLinda Tallen and David Paul

Kane Cancer Education and Research Foundation

Susan G. Komen Breast Cancer Foundation

The Harold McAlister Charitable Foundation

Maria Lim McClayMelanoma Research AllianceNancy and Carroll O’ConnorMargie and Robert E.

Petersen FoundationQVCGene Raymond EstateThe Lois Rosen FamilyCheryl and Haim SabanThe Samueli FoundationThe Tarble FoundationThe Wayne and Gladys

Valley FoundationThe Family of John WayneThe John Wayne

Cancer FoundationRuth Weil

DIAMOND CIRCLE ($500,000+)The Carole Zumbro and

George Adler FamilyMrs. James M. Amyx, Jr.The Danny Arnold FamilyMarsha and Martin BranderPatricia C. Brown FoundationLarry and Lynn BrownMr. and Mrs. Christopher H.

Buehrle in Memory of Sharon

Buehrle & Alan J. PinkstaffBuehrle Golf ClassicCalifornia Breast Cancer

Research ProgramCalifornia Cancer Research ProgramConstance and Sydney DunitzMickey and Bud ErhardtRanda and Ghassan GhandourThe William Randolph

Hearst FoundationsThe Lincy FoundationTom Mullin Memorial FundLloyd L. RossWhat A Pair!The Wrather Family

YELLOW SAPPHIRE CIRCLE ($250,000)Jackie and Howard BanchikJoan Berlin ReederLouis L. Borick FoundationLinda L. Brown and

MaddocksBrown FoundationMaria Lucia and Fernando

Diez BarrosoIlene EisenbergDiane and Daniel FeldmanMargo GrogerHenry L. Guenther FoundationThe Bob & Gaye Harris FoundationMichael KadoorieSandra Krause and

William Fitzgerald

CUMULATIVE GIFTSThe John Wayne Cancer Institute at Providence Saint John’s Health Center is honored to recognize the following Circles of Distinction members who have made cumulative gifts and pledges of $25,000 or more through January 31, 2014. Circles of Distinction members are recognized on individual plaques in the Institute’s main lobby.

Circles of Distinction Members who have made cumulative gifts and pledges of $25,000 or more are recognized on individual plaques in the Institute’s main lobby.


HONOR ROLL

Judith and Sandy LitvackMaxim PharmaceuticalsMr. and Mrs. James G. McFarlaneAlice and Verne McKinneyAnn MoorefieldJess and Palma Morgan FoundationDr. Donald and Lorraine MortonNational Operating Committee

Standards Athletic EquipmentHRH Prince Nawaf Bin NawafMr. and Mrs. Cyril NiggRoberta NovickLynda and Stewart Resnick Donna and Harvey RosenSimon-Strauss FoundationThe Steele Foundation in Honor

of Laura Perkins

EMERALD CIRCLE ($100,000+)America RemembersAmerican College of SurgeonsAmerican Health FoundationLance Armstrong FoundationMarilyn and Martin B. AugustSheri and Arthur BerkEstate of C. June BisplinghoffMr. and Mrs. James R. BoboBorstein Family FoundationThe Boudjakdji FoundationBulova Gale FoundationThe Rita Burkett Living TrustThe Campion FamilyThe Carnegie Hall CorporationChiron CorporationBonnie E. CobbIn Memory of Ellen CoopermanMr. and Mrs. John CreanMr. and Mrs. Neal DemMartha and Ronald DoorninkEastman Kodak CompanyMr. and Mrs. Louis W. EhlersThe People of Elko, Nevada, in

Memory of John Ellison, Jr.Patricia EltonEntertainment Industry FoundationMax Factor Family FoundationFarmers InsuranceThe Rod Fasone Memorial Cancer

Research Fund

Arthur J. Gallagher & CompanyHarold and Julia Gershman

Family FoundationDr. Cheryl F. and

Dr. Armando E. GiulianoFrank L. and Helen J. Gofrank

FoundationLeon and Toby Gold FoundationGreat Western BankJoyce and Jack GreenWilliam H. Hannon FoundationThe Nan M. & Reed L. Harman

FoundationBarbara and Ben HarrisSelma L. HerbertGeorge Hoag Family

FoundationSue and Larry HochbergEmma and Otto Immenroth

Family TrustIn Memory of Raymund A. Kathe

Berton and Todd KirshnerMr. and Mrs. Norbert E. KnollThe Stanley S. Langendorf

FoundationCynthia and Edward Lasker

FoundationElaine and Kenneth LeventhalEvan and Carol Li and FamilyRobert H. LorschAlicia and James McFarlaneMPI Media GroupMike and Muffy Murphy FundVictoria and Carl MurrayHeather and Jim MurrenGeorge W. OgdenThe Estate of Edgar Bishop Pease

and Eiko M. PeaseThe Rabinovitch FoundationThe Estate of Carl RomerSABCO Racing, Inc.The Estate of Edgar J. SaltsmanMr. and Mrs. Jeffrey SchwartzElizabeth and Henry SegerstromRuth L. and Norman ShacknoveThe Al Sherman FoundationThe Dinah Shore FoundationJaclyn SmithThe Candy and Aaron Spelling

FoundationMr. and Mrs. Sheldon E. StunkelThe Tenenbaum FamilyTYCO Healthcare

Earlane and Robert VallierMr. Robert J. VignoloThe Wallis FoundationDel E. Webb FoundationMr. and Mrs. Leonard WeilMrs. Kimberly Harris and

Mr. Scott WeinerMary Ann and Marvin WeissRodney F. Williams and Elizabeth

M. Williams TrustElizabeth WoodardMr. and Mrs. Joseph Zukin, Jr.Robert and Joan Zukin

RUBY CIRCLE ($50,000+)Mr. and Mrs. Stephen AllenRussell and Evelyn AnsethAuctionpay, Inc.Martin AugustBerlex Laboratories, Inc.Bea Blondell, Usula J. Scarrow, and

Mary Van HoutenBloomingdale’s, Inc.Harry and Helen BlusteenAndrew and Deborah BogenM’Lou and Bill BornThe Saul Brandman FoundationGracia Bremer

Charitable FoundationMary Frances and Jack BrennanGerald BronsteinAbbott BrownHollace Brown and

Lewis WallenskyThe Dr. Patrick Cadigan FamilyCancervax Corporation-Del Chartwell Charitable FoundationChubb & Son InsuranceCarol and Jerome CobenSandy and Irv CohenThe Collector’s ArmouryGary CoullMr. Robert L. DonleyDuke UniversityPat and Jerry EpsteinMary Frances and

Andrew J. FenadyBarbara J. ForemanThe Franklin Mint Foundation

for the ArtsEstate of Claude E. Gainer and

Thelma J. GainerBeatrice and Philip Gersh

Ronald and Catherine Gershman Foundation

Mr. and Mrs. Harvey S. GettlesonMarilyn and Allen GoldenLisa L. GoodmanMadelaine and Gene Gordon Gaile Gray RyanThe Green FoundationThe Brad and Jill Grey Family

FoundationMr. and Mrs. Richard HaftMr. and Mrs. Lloyd G. HallamoreThe Hammock Family FoundationHauptman Family PhilanthropiesBarbara A. HillmanThe Bob and Dolores Hope

Charitable FoundationInstitute for Cancer PreventionDr. Reiko F. IrieJudianne and Kenneth JaffeTera and Jason JeraldsKantor FoundationLenore Golden Kessler in Memory

of Rudy PerkalBernard J. Korn, MD and

Betty Roach Janice White and Eugene KriegerThe Lefkowitz Family FoundationIna and Bernard LewisDr. and Mrs. Israel LichtensteinMacDonald Family FoundationThe Family of Lorraine MannRuth K. March and FamilyMr. and Mrs. Leonard MautnerBernard John and

Beatrice McMorrowThe Melanson Family FoundationDonna J. MettlerModern Business InteriorsMuller Family FoundationMr. and Mrs. Jimmy MurphyNational Asset Recovery

Services, Inc.Arnold and Sherri NelsonMr. and Mrs. John F. NickollNovartis Pharmaceuticals

CorporationBradley S. O’LearyVictor H. PalmieriRalph and Marcia PetersonPhilip MorrisJennifer ProvineMarianne J. Reis

CUMULATIVE GIFTS (continued from page 41)

Stanley and Maida RichardsMildred and Chapin RileyAnn and Nathan Stafford RogersRichard RogersPhilip and Monica RosenthalDanielle Brown Ross and

Ronald Ross Eleanor Rothberg Linda Bernstein Rubin and

Tony RubinGertrude and William Rutledge John ShawDean Smith Celebrity RodeoHerb and Jacque SpivakThe Caryll M. & Norman F.

Sprague FoundationSurf City Tourneys, Inc.Eugene ThamesRobert and Diana Thom

Tower Imaging Medical Group, Inc.

Warren TreppTustin Brewing CompanyUniHealth FoundationUniversal Studios, Inc.Inna VainshtockValley Radiotherapy AssociatesVidfilm Services, Inc.Sandi and Dan WalkerThe Walt Disney CompanyAudrey J. Walton and Ann Walton

Kroenke Charitable FoundationBeti WardThe Weingart FoundationThe Weisenfeld FamilyWestern Classics-Wilma RussellWitherbee FoundationF. Michael and Robert Simmons

Wong FoundationVicky Wong Mr. and Mrs. Martin J. Wygod

BLUE SAPPHIRE CIRCLE ($25,000+)Agouron Pharmaceuticals, Inc.

Marianna and Harry AllgauerMaria and Emilio ArechaederraAssociation of Women Surgeons

Foundation Timothy Aycock Melanoma

Research FoundationThe Solomon R. and Rebecca D.

Baker FoundationJannell and Randy BanchikIrene and Don BaronAnne BarryThe Cecile & Fred Bartman

FoundationElizabeth G. BeckBernice and Harold BelferDaisy and Daniel BelinRichard BenderSue BenderMr. Jeffrey C. Beyer

R. J. BrennerJacqueline BurdorfDr. Michael CaanDr. MaryLou Ozohan and

Mr. Andy CamachoBarbara and Harlan CareyMr. and Mrs. William ChristopherEvelyn Mandel and Geralin Clark Horace O. Coil Living TrustJoan Walkup CorriganMarissa CoughlanIn Loving Memory of

Donna J. CoxeterJoe Crail Western Mutual

Insurance GroupFrances CutlerMrs. Nancy DeanDeluxe LaboratoriesIn Memory of Irene R. DiamantMrs. William H. Doheny, Sr.Farmers Insurance

Western DivisionMichael V. FerroneWilda and Paul FetterolfMrs. Bernice FineEdward and Sandra Fineman

Lynne and Michael FlynnDarlene FogelSteven FogelFoote, Cone & BeldingAlain and Myra GabbayThe Robert Garthwait FamilyLucy and Francis GartlanGenta IncorporatedThomas and Gerrianne GoffElma Sylvia and W. Earl GoldbergStan and Pat GoldmanJohn GouldthorpeJulia and Ken GouwReva GraziadioPamela and Neal GreenLisa and Marty GreenbergGuthy Jackson Charitable

FoundationAnn G. HarmsenIn Memory of Cathy HasselbergerShila Hazan—In Memory of

Morrie HazanJanet and Stanley ImermanJewish Federation of

Metropolitan ChicagoLouis JohnsonThe JS TrustKaren and Lonnie KaneLinda KaplanKarl-Storz Endoscopy-America, Inc.Andrea KatzKelton Fund — Lenny and

David KeltonMichael KingKLM FoundationMrs. Virginia M. KnottAndrea and Larry KopaldJoyce and Lou KrasnyDiane KriegerAlice and Nahum LainerMr. and Mrs. Tom H. LangRichard C. LeviSuzanne and Jay LichterMr. and Mrs. Hal LindenThe Litt Family FoundationLOGS Financial Services, Inc.Barbara and William LongLorraine and Elliot B. LubinWendy and Greg LumsdenMarilyn MaroneyMarshall Edwards

Pty Ltd (MEPL)Bruce and Sandra Massman

Margaret A. MawKathleen L. McCarthyPatricia and Don McFarlaneDon H. MeinholdMilken Family FoundationPatrick MortonSheila MullerMr. and Mrs. Terry MullinMutual of OmahaJosephine NaifyThe Ronald Newburg FoundationThe Kenneth T. and Eileen L.

Norris FoundationNovartis Pharma AGRobert J. NovickJames R. Olsen Shelley J. PerelRudy PerkalSandra and Lawrence PostWilliam H. Prusoff FoundationMr. and Mrs. Phillip PurerGladys and Ralph ReisfeldRita Medical SystemsJ. Marshall RobbinsMaxine RobinsonMr. and Mrs. Robert RoemmeleLee RogersConstance E. RopoloSheri and Seymour RosenblumGertrude C. RutledgeStephen RuvitusoAda and Leonard SandsAlvin SargentDena SchechterSchering Sales CorporationSandra and Vincent ScullyKretta and James ShanerDavid and Beth ShawTeresa and Alan Smith Ruth Z. SolomonSouthwest Oncology GroupJacque SpivakThe Stark Family TrustLarry and Marlene SternBarbra StreisandGloria StrelitzSherry Sexton Striepeke and

Dan StriepekeAnita and Tim SwiftEugene and Florence TandeSandra and Robert TeitsworthFerne Marshall TheisLawrence H. Thompson


HONOR ROLL

Those who are happiest are those who do the most for others.”

—Booker T. Washington

HONOR ROLL


Mary M. ThompsonSandy TsukamotoJoe and Janet TydlaskaUnion Bank of CaliforniaSusan L. and Richard VeermanEmily and Gregory WaldorfSharon and Joel WallerRandi WeilWells Fargo FoundationHarriet WernerRoberta M. White in Memory of

Harvey I. WhiteRita Wilson and Tom HanksThe Gary and Karen Winnick

FamilyJoan and Robert YoungLaura ZiskinJoan Zukin

Barbara and Stephen L. AllenAgnes AndersonPatricia L. AntunaDorothy AvazianMr. and Mrs. Gordon S. AyersJackie and Howard BanchikJannell and Randy BanchikMr. and Mrs. Marvin M. BarofskyJohn R. BaroneBernice and Hal BelferMarilyn BernardC. June Bisplinghoff

Helen and Harry BlusteenBrenda and Alan BorsteinMs. Janice H. BurrillDouglas and Mary ByardJerome C. ByrneThe Patrick F. Cadigan FamilyRobert E. and Carol T. CanigliaGeralin A. Clark and

Evelyn MandelRoy E. CoatsSandy and Irv CohenHorace O. CoilGary W. CookMrs. Aziza CourahJanien DaleySherry and Charley DarganRobert Campbell and Alpha de

Monte-CampbellNancy L. DeanCarolyn Dirks and Brett

DoughertyRobert L. DonleyConstance and Sydney DunitzRichard Andre EspinosaDiane and Daniel FeldmanSteven FeldmanMary Frances and Andrew FenadyDavid Gabriel FineMartha J. FranklinClaude E. Gainer and

Thelma J. GainerGloria and John GebbiaBrian and Tracy GeschickterMr. and Mrs. Paul GilbertElma Sylvia and W. Earl GoldbergHarry and Eve Goldberg Julie and Stanley GoldhaberLeslie and Susan Gonda Marcia L. GoodmanGaile Gray RyanJoyce Green Margo GrogerWilliam B. Grover and

Joyce R. GroverLawrence S. HamiltonRuth and Harry HansonRuth HenkinSelma L. HerbertSue and Larry HochbergGlen Iino

Emma and Otto ImmenrothJanet E. InksterDavid and Carlene IwerksJudianne and Kenneth JaffeSharon JamesDavid Paul Kane and

Linda Tallen Kane Linda M. KaplanLinda and Alan KatzMrs. Beatrice S. KaufmanMr. and Mrs. Barry KayeRobert KelljanMichael S. KennedyHildegard T. KnollRev. James KollingRonald A. LairdAudrey and Jack LeifEdel LimprechtJudy LitvackPhyllis and George LorentzenTerrence G. MaloufDarley M. MarksRobert L. MartinLorraine and Donald MazzeoMaria Lim McClayProfessor Gerald T. McLaughlinMr. and Mrs. Van N.

McWhirter, Jr.Rose M. MikuleckyMrs. Maureen MillerMarilyn W. MitchellLillian and Richard MoorePat MortonTomiko MosleyPeter Richardson MullenJosephine Wayne NiggJulia Fischer and Howard D. NunnGeorge W. OgdenKatherine and Ronald OkunJuanita J. PattersonDr. Edgar B. Pease and

Eiko M. PeaseAngela PorfidoRichard PriceEarl and Victoria PusheeAnnette PyesCarole D. RalstonDale and James RansomMaida and Stanley RichardsAnn and Nathan Stafford Rogers

Carl RomerMs. Constance E. RopoloThe Lois Rosen FamilyMs. Eleanor RothbergEdgar J. SaltsmanJudy and Thomas SchatzmanDr. Stanley R. SchoenEllen SchuckGary L. SchwandnerMr. and Mrs. Steve ShaganJames A. ShanleyCaroline and Richard ShineeJohn Shuba, Jr.Jack SilberkleitMr. Albert E. SmithMarjorie and Ronald SouzaSherry Sexton Striepeke and

Dan StriepekeDiane J. SweetMary and Eugene SzeEugene ThamesHazel M. ThrockmortonVickie Tomastik-SproattEarlane and Robert VallierMary Van Houten, Ursula Scarrow,

Bea BlondellAnita and James VieceliMr. and Mrs. Robert Ray WallacePrimavera and Luis WatkinsDorothy WatsonMelinda Wayne MunõzRuth Weil Mary Ann and Marvin WeissHarriet Phillips WernerRodney Fargo Williams

and Elizabeth M. Williams Lee and Bill WoodIrene and Edwin Wright

If you would like to learn more about the Guardians of the Future and benefits of charitable estate planning for you and your family, please contact Tanya Lopez, director of planned giving, at 310-582-7095.

We have made every effort to ensure the accuracy of this listing. If we have made a mistake, please accept our apologies and let us know so we may correct it. Please contact 310-315-6111 or email: [email protected]

GUARDIANS OF THE FUTUREJohn Wayne Cancer Institute is honored to recognize the following visionary donors who have included the Institute in their estate plans as members of a special honor group, the Guardians of the Future. Members are listed permanently on the Guardians of the Future plaque in the Institute’s main lobby.

Creative Director:Art Director:Studio:Print Production:Copywriter:Account Executive:

Client: Saint John’s Health Center

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BUT YOUR INCOMEWO N ’ T.

Yo u r h a i r l i n em a y r e c e d e

Establishing a charitable gift annuity with the John Wayne Cancer Institute at Saint John’s Health Center helps make it possible for us to continue as a leader in cancer research, resulting in significant breakthroughs. It also provides you with some unique benefits:

• Lifetime income stream for you, and a loved one if you choose

• An immediate charitable tax deduction

• The flexibility to fund your annuity with cash, securities or real estate

• Fulfillment, knowing that your gift helps fund our award winning team of doctors

in their effort to find a cure for cancer

www.JWCI.org

Call Tanya Lopez at 310.582.7095 or email [email protected] or visit www.newsaintjohns.org/plannedgiving to learn more.

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Public Affairs and Development Office2200 Santa Monica BoulevardSanta Monica, CA 90404 USA

www.jwci.org

INNOVATIONS is made

possible by the generous

support of The Juels Eisenberg Fund.

NONPROFIT ORGANIZATION

U.S. POSTAGE

PAIDLOS ANGELES, CA

PERMIT NO. 31327

Immune System Mysteries

Bright Future

Researchers make strides in understanding how the immune

system can help fight cancer.

Teamwork, flexibility and ingenuity give rise to big ideas, both in

clinical practice and research.

Stay up-to-date on the latest news in cancer research by following us on Facebook:

www.facebook.com/JohnWayneCancerInstitute

CONNECTWITH US

OUR MISSION

John Wayne Cancer Institute at Providence Saint John’s Health

Center is a cancer research institute dedicated to the understanding and curing of cancer in order to eliminate

patient suffering worldwide.

Our mission is accomplished through innovative clinical and laboratory research and the education of the next generation of surgical

oncologists and scientists.

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Innovations - Spring 2014

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