ANTIBIOTICS
ANTIFUNGALS
BIOACTIVE COMPOUNDS
ANTIOXIDANTS
PIGMENTS
NUTRITIONAL ADDITIVES
COLORING AGENTS
ANTIOXIDANTS
INNOVATIVE AND NATURAL ACTIVE MOLECULES FOR HEALTH, NUTRITION AND COSMETICS
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1
cutting-edge
technological
platform
2 development
paths
Partnerships
Self-sustained
DEINOVE HARNESSES BIOLOGICAL
DIVERSITY TO DEVELOP
INNOVATIVE COMPOUNDS FOR
SUCCESSFULL APPLICATIONS IN
THE HEALTH, NUTRITION AND
COSMETICS INDUSTRIES
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6,000
proprietary
strains
160 patent
applications
1,500 m2 of
laboratories
3 industrial
partners
50
highly-skilled
staff
A COLLECTION OF 6,000 STRAINS
DEINOCOCCUS AND OTHER RARE AND EXTREMOPHILE BACTERIA
3
4 years of harvesting in
numerous hostile environments:
beaches, glaciers, hot springs, volcanoes, lagoons…
1,200 collection points
A patented selection method
using UV radiation
6,000 strains
available
DEINOVE is the sole company leveraging this
extraordinary ability displayed by “hyper resistant”
micro-organisms.
The Company screens for and recovers
compounds that enable the body to better
withstand external aggressions.
A COLLECTION OF 6,000 STRAINS
Wild-type strains producing novel compounds for a wide range of applications
A UNIQUE AND HIGHLY DIVERSIFIED SOURCE OF NOVEL COMPOUNDS
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Antibiotics
Pigments
Antioxidants
Oligo-
saccharides
Antifungals
Lipids
Anti-aging
EnzymesProteins
Moisturizers
Health
Food
Feed
Cosmetics
ENGINEERING BIOLOGY
NATURE AND TECHNOLOGY WORKING AS ONE
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COLLECTION AND PRODUCTION
OF EXTRACTS
CUTTING EDGE
ANALYTICAL PLATFORM
SCREENING• In vitro and In cellulo
• Test the strains
• Identify interesting features,
production of compounds of
interest
FERMENTATION
EXTRACTION, PURIFICATION• Test and optimize the production process
in increasing volumes
• Produce extracts for testing (efficacy,
pharmacological properties…)
AUTOMATED GENETIC
ENGINEERING• Optimize the strain for end use:
yield, biodisponibility…
• Determine the structure of compounds
produced (antibiotics, carotenoids)
• Analyze the strain metabolism for
optimization purpose
• 6,000 Deinococccus strains
and other rare bacteria
• Culture, selection and
production of extracts
• Sequencing
MOLECULES
OF INTEREST
AN AUTOMATED GENETIC ENGINEERING PLATFORM
BUILTON AN UNCOMMON MICROORGANISM… AND EXPANDED ON OTHERS
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Strong link with
bioinformatics tools and data
A continuously enriched
DNA database
High-throughput handling of
strain constructions
Highly standardized
Design/Build/Test&Learn pipeline
A CONSISTENT FERMENTATION TECHNOLOGY PLATFORM
FOR PROCESS DEVELOPMENT AND OPTIMIZATION
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34 fully instrumented bioreactors
From 1 to 20 liters
Connected with mass spectrometry
Batch – Fed-batch - Continuous
UN LABORATOIRE DE CULTURE CELLULAIRE
QUI VALIDE LE POUVOIR DES MOLÉCULES
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In vitro
In cellulo
Spectrophotomètre
Incucyte
CellInsight CX7
CytolyseCicatrisation
Extraits bactériens
Imagerie en
temps réel
Screening multi-
dimensions
SOLUTIONS FOR COSMETICS
A CATALOG OF COSMETIC ACTIVE EXTRACTS
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Antioxidant
Anti-aging
UV protection…
Healing
Anti-aging
Damaged skin…
Lipid storage
Moisturizing effet
Plumping effect…
Anti-inflammatory
Sensitive/irritated skin
Post-operative skin care…
Lipolysis
Slimming
Anti-cellulite…
Dozen of
DEINOVE’s strains
with confirmed
properties
A partnership with to co-develop and market new active ingredients for skin care
FOCUS ON CAROTENOIDS FOR FOOD, FEED AND COSMETICS
HIGH-VALUE SPECIALTY COMPOUNDS
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Aim
Offer a competitive bio-based alternative
Natural carotenoids
Supply stability and consistent high quality
Conservation of natural resources
Cost-effective process
Business model: Royalty-based license agreement / Direct sales of compounds (toll-manufacturing)
Step I Step II Step III
Jan.
2014
Feb.
2016
Feb.
2017
Target selection
Optimize strains (yield,
stability) and fermentation
conditions
Design the extraction and
purification process
Product formulation
Scale-up
Develop the metabolic
pathway: 5 molecules
produced at lab-scale
Oct.
2016
Step IV
Evaluate the functional
properties of compounds
Regulatory process
Q3
2018
Goal:
1st batches
marketed in 2018
Metabolic engineering in order to
improve production parameters
(yield, productivity…), hence
achieving industrial efficiency
PERFORMANCE
COST-EFFICIENCY
Screening among the
biodiversity of the microorganism
bank in order to find innovative
compounds for targeted
applications
INNOVATION
NATURALITY
CAROTENOIDS
A TWO-PRONG STRATEGY
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Engineering Extraction
CAROTENOIDS
KEY ADVANTAGES FOR DEINOCOCCUS
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400 strains naturally producing carotenoids among the Deinove library
Pathway for carotenoid biosynthesis is already present and active: optimizing the
metabolic performances is easier and more cost-efficient
High-level production can be obtained by metabolic engineering
Fast growing (growth rate= 0,6 h-1)
High cell density (50-60 g/L)
Production from diverse feedstocks (C6 sugars, C5 sugars, polymeric sugars like starch)
A story to be told (3.4 billion-year-old bacterium, anti-aging properties…)
CONTACTS
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Montpellier, FRANCECAP SIGMAZAC Euromédecine II1682 rue de la Valsière34790 GRABELSwww.deinove.com
Emmanuel PETIOTCEOTel.: + 33 6 13 80 25 [email protected]
