Recycle Your Old Cell Phone,Make a DifferenceTHE G&P FOUNDATION countinues its partnershipwith Charitable Recycling to provide a helpfulalternative to the disposal of cell phones in land-fills. Just donate your old cell phone andCharitable Recycling will refurbish and distrib-ute them to provide emergency services to bat-tered adults and children, senior citizens andmedical patients awaiting organ transplants. Foreach cell phone collected, The G&PFoundation will receive $1.00 for its mission tofund research until a cure for cancer is found.

All cell phones regardless of age or workingcondition are accepted. Make certain to deacti-vate your phone prior to donation by contactingyour service provider. For information visit,www.charitablerecycling.com and indicate TheG&P Foundation as the beneficiary of your cellphone donation.

THE PURPOSE OF The G&P Foundation forCancer Research is to encourage the develop-ment of more effective therapies forpatients with leukemia, lymphoma and relat-ed cancers. The Foundation funds innovativeclinical or basic science research that will leadto novel therapeutic approaches that couldreplace, or be used in combination with existingeffective therapies. Such therapeutic approachescould include integrative (integrative/comple-mentary) medicine.

The Foundation funds research to improve theefficacy of cancer treatments, reduce their toxic-ity and improve the quality of life of patientswith leukemia or lymphoma.

The Foundation also supports limited scientificinterchange between select leaders in differentareas of bio and integrative medical research, todevelop unique and important collaborative effortsthat will lead to improvements in the treatmentand care of patients with leukemia and lymphoma.

”

Your Invitation to Purchase Limited Edition Medals

18 KARAT GOLD &STERLING SILVER MEDALS

From The British Royal MintTo order your commemorative Gabrielle Rich Aouad medal,

fill out the enclosed order form or call the Royal Mint at 1-800-221-1215.

When ordering, please refer to the medals by theirproduct numbers:

GOLD #B2BFGP and SILVER #B2BAFSPA portion of the sale of each medal benefits

The G&P Foundation.

G&P Mission Statement

Early detection and intervention can help increase the chancesof overcoming cancer. If you are experiencing any of the follow-ing symptoms, see your doctor immediately:

• Painless swelling of lymph nodes (neck, armpits, groin orabdomen)

• Fever and night sweats

• Indigestion and abdominal pain; loss of appetite

• Bone pain

Know What To Look For-Warning Signs That CanSave Your Life

THANK YOU FOR YOUR SUPPORT.

InspirationsInspirationsWINTER 2006 | VOLUME 8 A Newsletter from The G&P Foundation for Cancer Research

A STAR-STUDDED ARRAY OF CELEBRITIES joined Grammy-nominated songwriter andG&P Co-Founder Denise Rich at the New York Marriott Marquis for the fourth AngelBall gala, helping to raise $3.3 million for The G&P Foundation for Cancer Research.The black-tie benefit, which featured a cocktail reception, dinner and live auction,recognized four honorees for their outstanding contributions as humanitarians andphilanthropic leaders: singer/songwriter Patti LaBelle; Russell Simmons, Chairmanand CEO of Rush Communications; Kimora Lee Simmons, Creative Director, BabyPhat; and GLAMOUR Magazine Editor-in-Chief Cindi Leive.

The triumph of the night’s fundraising efforts was highlighted by a $1 milliondonation from the royal family of Abu Dhabi. Due to the great success of this event,The G&P Foundation will fund seven new Medical Research Awards in 2006 with theproceeds from Angel Ball 2005.

Legendary vocalist Patti LaBelle segued from her acceptance speech into a surprise,heartfelt rendition of “Somewhere Over the Rainbow”, and was joined by StevieWonder at the piano, Natalie Cole and Wonder’s daughter, Aisha Morris. The nightculminated with all of the performers uniting onstage to sing the Martha Reevesclassic “Dancin’ in the Streets.”

The Angel Ball 2005 also featured performances by Ruben Studdard, Nelly, LeelaJames, BeBe Winans, Miri Ben-Ari and Shawn King. Other celebrities participated bydonating their time and talents as presenters including Star Jones Reynolds, KellyRipa, Lorraine Bracco, Joy Behar and Montel Williams (both served as the evening’sauctioneers), Jamie-Lynn Sigler, Ivana Trump, Joan Collins, JoJo, Debra Lee andFelicia Taylor, among others.

The Angel Ball is held biennially in memory of Gabrielle Rich Aouad (1969 - 1996).Angel Ball 2005 was sponsored by Donald Toresco of Toresco Enterprises, Inc.,Condé Nast Publications and PhRMA.

Board of DirectorsDenise Rich

Co-Founder

Philip AouadCo-Founder

Deborah Dunsire, M.D.Millennium Pharmaceuticals, Inc.

Star Jones ReynoldsThe VIEW

Clifford Perlman, Esq.Perlman & Perlman

Frank RellaTrine Corporation

Michele RellaDirector

Daniella RichDirector

Ilona Rich SchachterDirector

Paul Schindler, Esq.Greenberg Traurig, LLP

Donald TorescoToresco Enterprises, Inc.

Erin ZammettGlamour Magazine

Medical Advisory BoardChair: Dr. Stephen D. Nimer

Memorial Sloan-Kettering Cancer Center

Dr. Barrie R. CassilethMemorial Sloan-Kettering Cancer Center

Dr. Curt I. CivinJohns Hopkins University

Dr. Jerome GroopmanHarvard Institute of Medicine

Dr. Julie A. RossUniversity of Minnesota Cancer Center

Dr. Janet D. RowleyUnivesity of Chicago

Dr. Rainer F. StorbFred Hutchinson Cancer Research Center

Dr. Jeffrey D. WhiteBethesda, Maryland

Dr. Cheryl L. WillmanUniversity of New Mexico Cancer

Research Facility

StaffJennifer Ranieri

Christa Justus

41 East 11th Street,Floor 11

New York, NY 10003Tel: 212.905.6200Fax: 212.905.6203

www.gpfoundation.cominfo@gpfoundation.com

Denise Rich and Friends Help Raise $3.3 MillionFor Cancer Research at The Angel Ball 2005

The Angel Ball 2005 (Photos continued on pages 4-6)

1. Daniella and Denise Rich

2. Cindi Leive3. Louisa Bohm, L.

Marilyn Crawford,Michele Rella, DeniseRich, Patti LaBelle,Stevie Wonder, AishaMorris, Leela James

4. Nelly, Jerry Inzerillo5. Wynonna Judd6. Kelly Ripa

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Angel Love For SaleLimited-Edition Angel Love Tank Tops

THE G&P FOUNDATION HAS TEAMED UP with chic women’s clothing company,

Priorities to create a limited-edition Angel Love tank top to be offered

exclusively at www.prioritiesnyc.com. The crystal embellished tank tops,

designed by Priorities President, Stefani Toonkel-Greenspan, echo the theme of

the Foundation and will retail for $30.00. Thanks to the generosity of Priorities,

100% of the net proceeds of every tank top sold will go directly to The G&P

Foundation ($19.00) and our mission to fund research until a cure is found. To

place your order call 212-905-6202, fill out the enclosed order form or shop

online at www.prioritiesnyc.com. Thank you for your support!

ASPEN – ON DECEMBER 29, 2005 FRETTE, the esteemed luxury linens brand,

hosted a shopping day and reception at their Aspen boutique to benefit The

G&P Foundation for Cancer Research. Frette generously donated 20% of the

sales on that day to the Foundation’s program of funding cancer research, with

a focus on leukemia, lymphoma and other blood related cancers. The event

was a huge success, raising over $3,500 for the Foundation. The G&P

Foundation wishes to express special thanks to Alison Newman and Linda

Guterman of Frette for making this event possible.

The luxury linens brand Frette has always been associated and intertwined

with quality and has become an esteemed brand throughout the world, well

known for its workmanship and finishing touches. The quality linens may be

viewed and purchased at www.frette.com in addition to stores situated

worldwide.

Frette Shopping Extravaganza A Success – Proceeds Benefit Cancer Research

ORDER NOW!www.prioritiesnyc.com

212-905-6202

Norma Smith, Denise Rich, Linda Guterman,Linda Guterman of Frette, Helen Klanderud

Meet Our MedicalAdvisory Board!Third in a SeriesIN OUR CONTINUING EFFORT to introducereaders to the esteemed physicians on TheG&P Foundation Medical Advisory Board,Inspirations presents its series of interviewsshowcasing a member of our board in theirown words.

In this third installment, we are proud tointroduce you to Janet Davison Rowley, M. D.of The University of Chicago. Dr. Rowley isthe Blum-Riese Distinguished ServiceProfessor in the Departments of Medicine,in Molecular Genetics and Cell Biology andin Human Genetics. She received hermedical degree from the University ofChicago in 1948. She joined the researchfaculty at the University of Chicago in 1962and became a Professor in 1977. Dr. Rowleyhas contributed significantly to advances inunderstanding of genetic changes in cancer.Her discoveries have revolutionized the viewof hematologists/oncologists and cancerbiologists regarding the critical importanceof recurring chromosome abnormalities incancer cells.

She has published over 400 papers and bookchapters describing her research inleukemia and related areas and has receivednumerous awards including Dameshek Prize(1982), Medal of Honor (ACS, 1996), and morerecently the Dorothy P. Landon Award(2005). She is a member of the NationalAcademy of Sciences (1984), Institute ofMedicine (1985), American Academy of Artsand Sciences (1991), and AmericanPhilosophical Society (1993). She hasreceived nine honorary degrees includingone from Oxford in June 2000 and fromLund in 2003.

JANET DAVISON ROWLEY, M. D.

“I should begin by saying how important Ithink the work of the Foundation is,especially today as budgets for science arebeing constrained by other federalrequirements. The goal of The G&PFoundation namely to fund young scientistsand physicians and others involved in thecare of patients with cancer is more neededthan ever. Young scientists have a very hardtime breaking into the system and gettingfunding for starting their laboratories. I wasvery fortunate back in 1962 when I began inresearch to be part of a project that wasfunded by the national government so Ididn’t have to apply for grants in the firstfew years.

The project that I have been involved infor more than thirty years is the study ofgenetic changes in leukemia cells andlymphomas. The tools I used to studythese genetic changes in the malignantcells were chromosomes. The normalhuman cell has 46 chromosomes of partic-ular sizes and shapes. What has becomeapparent over the course of my studies isthat many leukemia cellshave altered chromo-some numbers (too manyor too few) or they havealtered chromosome sizesand shapes due to breaksin chromosomes andrearrangements.

I was very fortunate in1972 to be the first toidentify the chromo-somes involved in two ofthese re-arrangements,called “translocations”.In cancer and especiallyleukemia and lymphoma,chromosomes are brokenin specific places, andtheir ends are swappedso that different size pieces of the chro-mosomes are exchanged. This leads toidentifiable changes in the chromosomeswhen you look at them under the micro-scope.

The most well known translocation I dis-covered was one involving chromosomes9 and 22. It had been known since 1960that a particular form of leukemia calledChronic Myeloid Leukemia (CML) had aunique small chromosome. Because itwas discovered in the city of Philadelphiait was called the Philadelphia or the Phchromosome. With the staining tech-niques that were used at the time, chro-mosomes all stained uniformly. Theycould identify this very small markerchromosome but how it came to be wasn’tclear. I applied a new technique thatshowed that each chromosome pair had aunique pattern of alternating dark andlight stripes to study this mystery markerchromosome. I could see that in fact thePh chromosome was actually a transloca-tion where a large piece of chromosome22 went to the end of chromosome 9 and asmaller piece of chromosome 9 went tochromosome 22 giving rise to this smallPh chromosome.

The importance of this is that other labo-ratories analyzed the DNA at the sites ofthe chromosome breaks and discoveredthat the gene on chromosome 9 was theAbelson gene, which had already beenidentified in a mouse leukemia. The con-sequence of the translocation was tobreak within the gene and to move part ofthe Abelson gene to chromosome 22, next

to a gene called BCR thatis also broken. So youend up with a new,unique fusion gene onthe Ph chromosome,which consists of part ofthe normal BCR gene on22, fused to the back half,if you will, of theAbelson gene, which isnormally on chromo-some 9.

This fusion leads to theactivation of the Abelsongene whose function isas a tyrosine kinase. Thetyrosine kinases act toincrease cell growth.The fusion then leads

these cells to grow not necessarily morerapidly but it keeps them from stoppinggrowth when there is sufficient number ofwhite blood cells. This, in turn, withother genetic changes whose identity isunknown at the present time, leads thecell to become a leukemic cell.

This discovery has turned out to beextremely important because others, mostespecially Brian Druker at Oregon Health& Science University, working with achemist at Ciba, identified the compoundknown as STI 571 that inhibited thegrowth of cells with this abnormalAbelson fusion protein. This drug wasthen named Gleevec, now Imatinib, whichhas transformed the treatment of patientswho have CML.

The challenge for the future is to identifythe same kind of drug to treat patients whohave acute forms of leukemia, to treat themmore effectively. This is especially urgent forpatients who have Acute MyelogenousLeukemia (AML) who are older, i.e. over theage of 60, because the outcome oftreatment in these patients is still dismal.So, there is need for continued research tofind additional drugs to treat these otherforms of leukemia.”

The Angel Ball 2005

1. Marty Richards, Denise Rich andRick Friedberg

2. Lorraine Bracco and Joy Behar

3. Star and Al Reynolds

4. Carol Alt

5. Ian Behar, Unik Ernest and Donald Toresco

6. Judy and Rod Gilbert and Catherine Saxton

7. Ivana Trump

8. Hilary and Bryant Gumbel

9. Denise Wohl, Michele and Frank Rella

10. Vanessa Minillo and Daniella Rich

11. Leela James and Denise Rich

12. Debra Lee, Grace Hightower, FeliciaTaylor, Star Jones Reynolds andLorraine Bracco

13. Kimora Lee Simmons and Russell Simmons

14. Shawn King

15. Lisa Loeb

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1. Denise Rich and Rita Cosby

2. Jojo

3. BeBe Winans

4. Jamie-Lynn Sigler

5. Marcy Warren

6. Gayle King, Patti LaBelle and friends

7. Erin Zammett and Nick Ruddy

8. Patty Findlay, Denise Rich andTiqui Atencio

9. Britney and Lisa Gastineau, Deniseand Daniella Rich

10. Tamara Tunie and guest

11. Ruben Studdard

12. Dennis Basso and Paula Schulhof

13. Montel Williams

14. Galina Novikov and Denise Rich

15. Stevie Wonder and daughter Aisha Morris

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The Angel Ball 2005

1. Althea and Bill Hickman

2. Carolyn Plotkin, Dawn Page, Becky Adelman, Amanda Plotkin and Dan Weisenfeld

3. Felicia Taylor and Denise Rich

4. Debra Lee and Nelly

5. Dr. and Mrs. Stephen Nimer

6. Patti LaBelle and Stevie Wonder

7. Joan Collins

8. Michele and Larry Herbert

9. Ella Krasner and guest

10. Martha Byrne

11. Denise Rich with Tatiana and Philip Aouad

12. Natalie Cole, Marc Bouwer, Patti LaBelle and Paul Margolin

13. Alison & Howard Lutnick and friends

14. Mr. and Mrs. Jose Mari Chan

15. Melissa and Michael Mithoff

PHOTO CREDITS –Karen Dolan, Patrick McMullan, Rob Rich

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AUCTION AER Lounge, LLC – Andy Unanue, AlainDucasse at the Essex House, Maria &Fernando Allende, Alpine CreativeGroup, Americana Manhasset, AvonSalon & Spa, Bath Bloomers, BetseyJohnson, Anaït Bian, Dennis Basso, Patti Brito, Blue Star Jets, Dr. FredericBrandt, Carelle Ltd., Roberto Cavalli,Cheesecake Aly, Inc., Jimmy Choo,Jacqueline Cohen Diamond & Jewelry &Co., C.O. Bigelow, Escada, Etro, DIVAExecutive Limousine, Inc., Ducati, EOSAirlines, Judy and Rod Gilbert, GLAM-OUR Magazine, gloss Day Spa, GretchenGray Jewelry, Dan Hallman,Hirshleifer’s, Jacob & Co., Janet Goldmanand Fragments, Jay Johansen, PamelaJohananoff, Judith Ripka Jewelry, NaeemKhan, Kiehl’s Since 1851, LambertsonTruex, La Mer, Adrienne Landau, LoewsMovie Corporation, L’Olivier FloralAtelier & L’Olivier Downtown, LondonJewelers, Longchamp USA, Inc., Mia &Kompany, M3 The Image Group,Madame Paulette Custom CoutureCleaners, Mara Khodara Fashions,MaxMara, Meyers USA, PatrickMcMullen, Modell’s Sporting Goods,One&Only Ocean Club, Marc Packer,Peace & Love Jewelry by Nancy Davis,The Peninsula Beverly Hills, Piranesi,Pratesi, Ramy Cosmetics, Raymond WeilUSA + DiMODOLO Int., RibotRestaurant, Robb Report, The RosenthalGroup for Aesthetic Dentistry, Sapa Restaurant, Sally HershbergerDowntown Salon, Sally HershbergerFace Place, Samantha Keely Smith,Lorraine Schwartz, Simmons JewelryCo., Dick Streim – Taylor Made Travel,The Savoy – A Fairmont Hotel, Dr.Howard Sobel, Swarovski NorthAmerica, Ltd., Trish McEvoy, ClaudiaUndesser, Valentino Boutique New York,David Yurman

SPONSORS ATTENDEE GIFTBAGUnderwritten by Louisa Benjamin-Bohm, Shleppers Moving & StorageAngel Love Tanks Tops, Barielle, Ben &Jerry’s, BMI, Cure Search NationalChildhood Cancer Foundation, DeniseRich Songs, Domain Entertainment, EOSAirlines, FIJI Water, Fountainhead Films,Freeze 24/7, Giorgio Armani Parfums,Laura Geller, GLAMOUR Magazine, JuliaGlasner & Said Belhadfa, gloss Day Spa,IZZE Sparkling Juice, Kimora LeeSimmons Beauty LLC, Albert M.Lefkovitz M.D. – Alaur Skin, TheLaundry Spa, M•A•C Cosmetics, “My SoCalled Normal Life” by Erin Zammett,Nick Chavez Beverly Hills, ParfumsGivenchy, Peter Thomas Roth ClinicalSkincare, Ramy Spa, Sofia MiniSparkling Blancs de Blanc, Steps forLiving, Inc., Universal Motown RecordsGroup, UTOWA, 785 Records

TALENT GIFT BAGAuberge Resorts – The Inn at PalmettoBluff, Aaron Basha, Henri Bendel, CarnetTravels.com, Roberto Cavalli, The CocoaRoom, Dempsey & Carroll, Deva Jewels,L’Occitane en Provence, Porsche Designs,Priorities, Seche, Silhouette Optical,Simmons Jewelry Co., Steve Madden,Robert Tateossian, Thierry MuglerParfums, TIGI – S Factor, Patricia WexlerM.D. Dermatology Serivce

THE G&P FOUNDATION GIVES SPECIAL THANKS TO THE FOLLOWING FOR THEIR GENEROUS CONTRIBUTIONS TO ANGEL BALL 2005

NEXT G&P EVENT SCHEDULED FOR OCTOBER, 2006! VISIT WWW.GPFOUNDATION.COM FOR UPDATES.INTERESTED IN BECOMING A G&P SPONSOR? CALL US – 212-905-6200.

Champagne Courtesy of Perrier Jouet Champagne,

The Charmer Sunbelt Group, Charmer Sales Company

Wine Courtesy of Pamela Stein

Water Courtesy of FIJI Water

Spirits Courtesy of Ketel One Vodka

Tribute Journal Paper Courtesy ofPANTONE