Copyright © 2011 Penguin Computing, Inc. All rights reserved
Interactive Preclinical Analytics
via GPU Cloud Platform
Copyright © 2011 Penguin Computing, Inc. All rights reserved
Penguin POD – Innovative HPC as a Service platform
> Strong Life Sciences business
> Proven models for delivery of SaaS on parallel platforms
Numira – Groundbreaking imaging technologies
> Medical imaging as a biomarker: rich analytics
> Cloud-based delivery of data, analytics, and collaboration
Results for Numira customers
> Globally available advanced pre-clinical imaging services
> Faster, more detailed and expressive imaging capabilities
> Ease of utilization, collaboration and communication tools
Numira and Penguin Partnership
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Copyright © 2011 Penguin Computing, Inc. All rights reserved
Scyld
ClusterWare™
Scyld TaskMaster™
Enterprise Linux
Compilers & Tools
Penguin provides Linux HPC Solutions
Professional
Services and
Engineering
Cluster
Management
Software
Linux Systems
Storage
Workstations Servers
HPC Clusters
HPC as a Service -
Penguin on
Demand
Optimized for Linux Ease of Management Elastic Computing Linux and Cluster Expertise
Intel® & AMD®
Rackmount
Servers
Storage
Networking
Infrastructure
GPGPUs
Professional
Workstations
Factory Integration
Onsite Installation
Training
Product Support
Software Support
Customized Service
Engagements
On-demand
environment
HPC ‘optimized’
Tiered ‘Pay-as-
you-go’ pricing
Premium set-up
and support
services
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Copyright © 2011 Penguin Computing, Inc. All rights reserved
On-demand HPC system
> Compute, storage, low latency fabrics, GPU, non-virtualized
Robust software infrastructure
> Full automation
> User and administration space controls
> Secure and seamless job migration
> Extensible framework
> Complete billing infrastructure
Services
> Custom product design
> Site and workflow integration
> Managed services
> Application support
HPC support expertise
> Skilled HPC administrators
> Leverage 13 yrs serving HPC market
POD Platform
Internet (150Mb, burstable to 1Gb)
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Copyright © 2011 Penguin Computing, Inc. All rights reserved
Base GPU server configuration
> 8 core, 2.6GHz Nehalem servers
> 24 GB RAM (DDR3-1333)
Dual C2075 NVIDIA Tesla GPUs
> Number of processor cores: 448
> Processor core clock: 1.15 GHz
> PCI Express Gen2 ×16 system interface
> Memory clock: 1.50 GHz
> Memory Interface: 384-bit 6GB
24 pieces 64M × 32 GDDR5 136-pin BGA, SDRAM
Full GPU management integrated into POD stack
$2.25 per server hour (volume discounts available)
Typical applications:
> NVIDIA RealityServer
> Reverse Time Migration
> MatLab
> NAMD
> custom applications
POD GPU Offering
5
Copyright © 2011 Penguin Computing, Inc. All rights reserved
Increasing customer needs for on-demand resource
> Hybrid, Overflow, Workload-specific
Growth for HPC in non-expert user base
Increased demand for research collaboration platforms
Strong cluster software platform
Low cost of goods as HPC systems manufacturer
Clear vision of product requirements for market
Broad customer base across Enterprise, Fed, EDU
Strong HPC expertise
POD Genesis
6
Copyright © 2011 Penguin Computing, Inc. All rights reserved
On-Demand HPC Cloud True HPC in the cloud on a pay-as-you-go
basis, rate varies by commitment (hourly,
monthly, annual)
Hybrid Cloud (burst-out) Penguin clusters with workflow migration to
POD, or included POD usage ( tools and
services provided as PS)
Private HPC Cloud OEM or Penguin partnership to provide a
dedicated cloud to a target group of
customers
Scyld Cloud Management System
(coming late 2012)
Software system to operate and manage a
highly secure HPC cloud system
Post-Purchase Collocation Collocation services at our Salt Lake City
Data Center
Turnkey Remote Managed Services Same remote system management
services that we use for POD, provided to
our customers!
Penguin HPC Cloud Services
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Copyright © 2011 Penguin Computing, Inc. All rights reserved
User Portal
Direct login:
ssh
scp
rsync
Login/register
View/download billing and usage
Portal access to Login VMs
Save/manage custom Login VMs
Create/manage groups
Request cluster configurations
Launch and manage jobs
Monitor cluster usage
Monitor job progress
POD Automation Portal System 2 – releases Q2, 2012
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Virtual Login Node
Compute Node
Compute Node
Compute Node
Compute Node
Compute Node
/home
/store/[username]
VLAN
User Facing Application
Application User
POD Portal User
Head Node
iSCSI Targets
9
Numira focuses on pre-clinical drug development & the
pain points that prevent rapid, confident decisions
Numira
Testing methods that are 20 – 30 years old
The immense amount of data being generated
Pain
Points
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Virtual HistologyTM Leader in high-resolution, 3D quantitative imaging
Birth Defects Atherosclerosis Brain / Vasculature
Arthritis Lung / Oncology Renal
Heart Defects
Ophthalmology
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Pain Point: Current Manual Methods Example: Osteoarthritis
2,000 digital, 3D slices of whole joint
Reproducible, quantitative results
oLinear
oVolume
oThickness
oRoughness
oChanges to bone
Significant cost reduction
o Fewer animals
o 5 – 6 weeks to finish
Non-Destructive
Interactive datasets
Numira’s Solution: Virtual HistologyTM
Methods are 20 – 30 years old
Time consuming & inaccurate
Razor blades & microscope slides
Disease is routinely missed
Requires many animals
Subjective results
16 - 20 weeks
Destructive
Problem:
Microscope slide
with a vertical slice
of a rat knee joint.
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Manage immense amount of data
1,500+ Pharma and Biotech companies
6,000+ drugs under development
Multiple imaging studies per drug
Dozens to hundreds of images per study
File sizes 1GB - 20GB per image
Access to Numira’s analytical tools
Fill the communication void
Rapid scale-up with multiple channel partners
Microsoft partnership in place
Others in process
AltaPortalTM
Cloud / SaaS solution for a large, unmet need
“It’s easier to repeat a study than find and mine data from a previous study.”
- Senior researcher at a Top 5 pharma
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Clients (HTML5)
Servers (Private or Hosted)
Encrypted
Data Storage Study Data
Imaging Data
Meta-Data
Analytics Statistical
Visual
Communication Annotation
Collaboration
Notification
Filter &
Search
Integration Other Study Data
Third party Apps
Other Databases
Galleries &
eNotebooks
Whiteboards &
Chats
Dashboards &
Tracking
Third party
Applications (via API)
Smart Phone / Tablet
(custom interface)
Standard Web
Browser
Authenticated & Secure
Network Communication
Technolo
gie
s
Serv
ices
AltaPortalTM
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Multiple Cloud Integration
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