UniversitätsKlinikum Heidelberg
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCERTranslating Basic Research into Clinical Practice
October 29-30, 2015Heidelberg, German Cancer Research Center (DKFZ)
KFO 227UniversitätsKlinikum Heidelberg
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Greeting
Metastatic disease remains a serious obstacle in colorec-tal cancer treatment. On the other hand, boosted by the advent of novel technologies, the recent years have seen major breakthroughs in our scientific understanding on how genetic alterations, molecular signatures and immune responses affect patterns of metastatic spread. While these insights clearly provide a scientific basis to advance the treatment of this widespread disease, translating them into clinical practice remains a formidable task, necessitating close interaction between basic scientists, translational researchers and clinical oncologists.
The International Symposium on Metastatic Colorectal Cancer will bring together high-profile experts and junior researchers from the fields of basic science, translational oncology and clinical oncology to discuss mechanisms be-hind metastatic colorectal cancer spread, as well as novel therapeutic options to be derived therefrom. Particular focus will be placed on molecular mechanisms of tumor spread, biomarkers indicating colorectal cancer progres-sion, innovative therapeutic targets, and interdisciplinary approaches for personalized treatment.
We cordially invite you to join us in the beautiful city of Heidelberg for an inspiring meeting, and to discuss how to translate current basic research insights into novel treat-ment options for metastatic colorectal cancer.
Markus W. Büchler
Alexis Ulrich
Martin Schneider
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
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AGENDA
Thursday, October 29, 2015
12:00 pm Registration Coffee + Opening Buffet
1:45 pm Welcome and Opening Remarks Alexis Ulrich, Martin Schneider Heidelberg, Germany
2:00 pm to 3:30 pm – Session 1 Basic mechanisms of tumor initiation and metastatic spread Chairs: Claudia Ball, Heidelberg Thomas Brabletz, Erlangen
› A stromal gene program that drives metasta- sis in colorectal cancer Eduard Batlle, Barcelona, Spain
› Epithelial to mesenchymal transition Thomas Brabletz, Erlangen, Germany
› Clonal dynamics in gastrointestinal cancers Claudia Ball, Heidelberg, Germany
› Significance of the tumor microenvironment Florian Greten, Frankfurt, Germany
› Minimal residual disease in colorectal cancer Sebastian Schölch, Dresden, Germany
3:30 pm to 4:00 pm – Coffee Break
4:00 pm to 5:30 pm – Session 2 Prevention and biomarkers Chairs: Susan Galandiuk, Louisville Cornelia Ulrich, Salt Lake City
› Primary prevention of colorectal cancer Cornelia Ulrich, Salt Lake City, USA
› Chemoprevention in Lynch Syndrome John Burn, Newcastle, United Kingdom
› Molecular tests for colorectal cancer screening Gerrit Meijer, Amsterdam, The Netherlands
› Plasma microRNA screening for colorectal cancer Susan Galandiuk, Louisville, USA
› Diagnostic potential of the gut microbiome as a biomarker for colorectal cancer Peer Bork, Heidelberg, Germany
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
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AGENDA
Friday, October 30, 2015
8:30 am Coffee
9:00 am to 10:30 am – Session 3 Novel therapeutic targets in metastatic colo- rectal cancer Chairs: Max Mazzone, Leuven Martin Schneider, Heidelberg
› Targeting solid tumor stem cells in colorectal cancer Ruggero de Maria, Rome, Italy
› Targeting PHD (prolyl hydroxylase domain) proteins in CRC Massimiliano Mazzone, Leuven, Belgium
› Significance of tumor-associated B-cells Michael von Bergwelt-Baildon, Köln, Germany
› Role of anti-apoptotic Bcl-2 proteins in CRC progression Bruno Köhler, Heidelberg, Germany
› Targeting of hypoxic pathways Martin Schneider, Heidelberg, Germany
10:30 am to 11:00 am – Coffee Break
11:00 am to 12:30 pm – Session 4 Immunotherapy for colorectal cancer Chairs: Matthias Kloor, Heidelberg Pedro Romero, Lausanne
› Clinical significance of the immunologic microenvironment Niels Halama, Heidelberg, Germany
› The immune biology of hereditary colorectal cancer Matthias Kloor, Heidelberg, Germany
› Therapeutic potential of T-cell responses Philipp Beckhove, Regensburg, Germany
› Therapeutic vaccination of cancer patients Pedro Romero, Lausanne, Switzerland
› Towards a vaccine against microsatellite-unstable colorectal cancer Magnus von Knebel Doeberitz, Heidelberg, Germany
12:30 pm to 2:00 pm – Lunch and Poster Viewing
Location: Foyer, DKFZ
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
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AGENDA
Friday, October 30, 2015
2:00 pm to 3:30 pm – Session 5 Personalized therapy for colorectal cancer Chairs: Hanno Glimm, Heidelberg Thomas Seufferlein, Ulm
› Cancer mutations and targeted therapies Giovanni Germano, Torino, Italy
› Clinical implementation of cancer genome sequencing: NCT MASTER Molecular Stratifi-cation Registry Trial Hanno Glimm, Heidelberg, Germany
› How to bundle and interpret OMICs-data for application in clinical medicine Benedikt Brors, Heidelberg, Germany
› Genetic traits predicting the efficacy of antian-giogenic therapy Diether Lambrechts, Leuven, Belgium
› Translating tumor biology into targeted cancer therapy: feedback from clinical trials Thomas Seufferlein, Ulm, Germany
3:30 pm to 4:00 pm – Coffee Break
4:00 am to 5:30 pm – Session 6 Interdisciplinary treatment of metastatic colo- rectal cancer Chairs: Jörg Pelz, Würzburg Jürgen Weitz, Dresden
› Surgical approaches for bilateral colorectal liver metastases Jürgen Weitz, Dresden, Germany
› Peritonectomy and HIPEC for peritoneal colorectal cancer spread Alexis Ulrich, Heidelberg, Germany
› Interventional radiology for ablation of colorectal liver metastases Boris Radeleff, Heidelberg, Germany
› Neoadjuvant therapy for colorectal liver metastases Niels Halama, Heidelberg, Germany
› Palliative treatment of metastatic colorectal cancer: recent clinical trials Henning Schulze-Bergkamen, Wesel, Germany
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INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
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SCIENTIFIC ORGANIZATION
Department of SurgeryGeneral, Visceral and Transplantation SurgeryHeidelberg University Hospital
Clinical Research Unit 227 (KFO 227) – Colorectal cancer: from primary tumor progression towards metastases
Alexis UlrichMartin Schneider
FOR INFORMATION, CONTACT
Daniela WaldonDepartment of SurgeryGeneral, Visceral and Transplantation SurgeryIm Neuenheimer Feld 11069120 HeidelbergGermanyphone +49-6221 56-36754Fax +49-6221 [email protected]
LOCATION
German Cancer Research Center (DKFZ) Im Neuenheimer Feld 28069120 HeidelbergGermany
CHAIRS AND SPEAKERS
Claudia BallDepartment of Translational OncologyNational Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Heidelberg, Germany
Eduard BatlleInstitute for Research in Biomedicine (IRB) Oncology – Colorectal cancer laboratoryBarcelona, Spain
Philipp BeckhoveGerman Cancer Research Center (DKFZ)RCI Regensburg Center for Interventional ImmunologyRegensburg, Germany
Peer BorkEuropean Molecular Biology Laboratory (EMBL)Heidelberg, Germany
Thomas BrabletzExperimental Medicine INikolaus-Fiebiger-Center for Molecular MedicineUniversity Erlangen-Nürnberg, Germany
Benedikt BrorsDivision Applied BioinformaticsDepartment of Translational Oncology, National Centerfor Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Heidelberg, Germany
John BurnInstitute of Genetic MedicineNewcastle University, United Kingdom
Ruggero De MariaIstituto Nazionale Tumori Regina Elena IRCCSRome, Italy
Susan GalandiukSection of Colon and Rectal Surgery, Department of SurgeryUniversity of Louisville, USA
Giovanni GermanoCandiolo Cancer Institute, Laboratory of Molecular GeneticsCandiolo, Torino, Italy
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Hanno GlimmDepartment of Translational Oncology National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)Heidelberg, Germany
Florian GretenGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental TherapyFrankfurt, Germany
Niels HalamaNational Center for Tumor Diseases (NCT) Department of Medical OncologyUniversity of Heidelberg, Germany
Matthias KloorDepartment of Applied Tumor Biology Institute of PathologyUniversity Hospital Heidelberg, Germany
Bruno KöhlerNational Center for Tumor Diseases (NCT) Department of Medical OncologyUniversity of Heidelberg, Germany
Diether LambrechtsVIB Vesalius Research CenterLaboratory of Translational Genetics (VRC)KU Leuven, Belgium
Massimiliano MazzoneVIB Vesalius Research Center, Department of OncologyUniversity of Leuven, Belgium
Gerrit MeijerDepartment of Pathology, Netherlands Cancer InstituteAmsterdam, The Netherlands
Jörg PelzDepartment of General, Visceral, Vascular and Paediatric Surgery, Center for Operative Medicine (ZOM)University Hospital Würzburg, Germany
Boris RadeleffDepartment of Diagnostic and Interventional RadiologyUniversity Medical Center Heidelberg, Germany
Pedro RomeroLudwig Center for Cancer ResearchUniversity of Lausanne, Switzerland
Martin SchneiderDepartment of General, Visceral and Transplantation SurgeryUniversity of Heidelberg, Germany
Sebastian SchölchDepartment of Visceral, Thoracic and Vascular SurgeryUniversity Hospital Carl Gustav Carus of the Technical University Dresden, Germany
Henning Schulze-BergkamenDept. Gastroenterology/Onkology/Diabetology/RheumatologyMarien-Hospital Wesel, Germany
Thomas SeufferleinCenter for Internal MedicineUniversity Hospital Ulm, Germany
Alexis UlrichDepartment of GeneralVisceral and Transplantation SurgeryUniversity of Heidelberg, Germany
Cornelia UlrichHuntsman Cancer Institute (HCI)Salt Lake City, USA
Michael von Bergwelt-BaildonHospital for Internal MedicineUniversity Hospital Cologne, Germany
Magnus von Knebel DoeberitzDepartment of Applied Tumor BiologyInstitute of PathologyUniversity of Heidelberg, Germany
Jürgen WeitzDepartment of Visceral, Thoracic and Vascular SurgeryUniversity Hospital Carl Gustav Carus of the Technical University Dresden, Germany
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HOW TO GET TO THE DKFZ
By Car:Take Autobahn A 656 to Heidelberg, in Heidelberg conti-nue on Bundesstraße B 37 to Universitätsklinikum/Neuen-heimer Feld“. Having crossed the Neckar River, turn left at the fi rst traffi c lights into „Jahnstraße“, then turn right into „Im Neuenheimer Feld“. Follow this street for about 100 meters, then turn left into Kirschnerstraße and pass the checkpoint. After another 200 m, you fi nd the DKFZ buil-ding on the right. Please use parking area P 22 between „Berliner Straße“ and „Im Neuenheimer Feld“.
By public transport:Tramways no. 21 (terminus „OEG-Bahnhof“) or 24 (termi-nus „Burgstraße“). Get off at stop “Jahnstraße“. Cross the street to the left and walk into „Jahnstraße“. Continue as previously described (5 mins. Walk approx.).
Buses no. 31 or 34. Get off at stop „Chirurgische Klinik“ or „Uni-Campus“.
Heiligenberganlage
Heiligenbergturm
A 656
161
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Stauwehr
ZOO
MannheimFlughafen
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Bismarcksäule
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Theodor-
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Med.Klinik
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Am Hackteufel
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Czer
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530
Schwimmbad
Institut für Sport undSportwissenschaften
700
710
Olympiastützpunkt Rhein-NeckarBundesleistungszentrum
720
Sportanlagen Universität
524
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516-519
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Technologiepark
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gieparkHTC
DKFZ
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523WohnheimeWohnheime
676 - 683
NCT
671
Gästehaus
Max-Planck-Institut
Geologie234
Mathematik URZ Phys.Chemie Mineralogie
Südasien-institut
252235
236294 293/292
253/254
Hör
säle
Chem
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330 269 7
050
7051
Geogr.Institut
PädagogischeHochschule
502560
561
MPI fürVölkerrecht
535
500
501 521
522
400
450430
410
672670
350
Chemische Institute
ZoologischesInstitut
270 - 278
Umweltphysik
229
230
231 232
Mathem.Institut
288
Hörsaal
304
Physik
227
100UBA
ZMBH
Tumorvirologie
UBA DKFZ
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241223
222
282242
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360
162 154
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155 151
159
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Botanischer
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345325
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Blutbank
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366 346 326 306
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344b
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110105111
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ZSW
Max-Weber-Haus
Bildungszentrumim Heinsteinwerk
Stadthalle
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Archiv
Mensa
Marstall
Alte
Aula
Neue Uni
Zentrale
Universität
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bibliothek
Klinikum Neuenheim
1 Kopfklinik INF 400 2 Medizinische Klinik INF 410 3 Kinderklinik (alt) INF 1533a Kinderklinik (Neubau) INF 430 4 Schmerzzentrum INF 131 5 Chirurgische Klinik INF 110 6 Pathologisches Institut INF 220/221 7 DKFZ INF 280 8 Hygieneinstitut INF 324 9 Institut für Immunologie Med. Biometrie u. Informatik INF 30510 Theoretikum11 Institut für Humangenetik INF 36611a Genetische Poliklinik INF 344a12 Otto Meyerhof Zentrum INF 35013 VZM / Apotheke INF 67014 Verwaltung / ZIM INF 67214a ZIM Tiergartenstr. 1515 Ionentherapie/HIT INF 45016 Zentrallabor INF 67132 Gästehaus INF 370/37134 Studiendekanat INF 346
Klinikum Bergheim
17 Familientherapie Bergheimer 5418 Frauenklinik (Pforte) Voßstr. 919 Brustzentrum/ Onkol. Ambulanz Voßstr. 9, Geb. 421020 Arbeits-,Sozialmedizin Voßstr. 2, Geb. 404020a Klinische Sozialmedizin Thibautstr. 321 Medizinische Psychologie Bergheimer 2022 Hautklinik Voßstr. 223 Rechts-,Verkehrsmedizin Voßstr. 223a Rechts-,Verkehrsmedizin Voßstr. 2, Geb. 404024 Psychiatrische Ambulanz Voßstr. 2 - 425 Psychosomatische Ambulanz Thibautstr. 226 Psychiatrische Klinik (Pforte) Voßstr. 427 Prinzhornsammlung Voßstr. 228 Kinderpsychiatrie Blumenstr. 829 Betriebsärztlicher Dienst Voßstr. 1130 Psychiatrie / Psychosom. Klinik Voßstr. 231 Bildungszentrum Wieblinger Weg 1935 KKS Voßstr. 2, Geb. 441036 Allg.Med / Vers.forschung Voßstr. 2, Geb. 4370
Parkplätze für Patienten und BesucherParkplätze für BeschäftigteKassenautomaten
PP320
370370
DKFZ
WE ARE INDEBTED FOLLOWING COMPANIES FOR FINANCIAL SUPPORT:
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
Gestaltung und LayoutMedienzentrum – Zentrale Einrichtung des Universitäts- klinikums und der Medizinischen Fakultät Heidelbergwww.klinikum.uni-heidelberg.de/medienID28045
Stand/Oktober 2015
