A Direct-Fed Microbial Solution to Help Promote Health, Immunity and Weight Gain in Poultry

Introducing Provia™ PrimeDirect-Fed Microbial

POULTRY

To learn more about Provia Prime,talk with a Phibro expert at 800.677.4623 or visit www.pahc.com.

This information has been prepared for industry technical professionals.

PV221218 © Phibro Animal Health Corporation.Phibro, Phibro logo design, Healthy Animals. Healthy Food. Healthy World. and Provia are trademarks owned by or licensed to Phibro Animal Health Corporation or its affiliates.

Figure 3. Mortality, Days 0-42

Mortality

When feeding Provia Prime, optimized microbiome health has been shown in trials to help reduce mortality by more than 85 percent at 42 days (Figure 3.).

As consumer, regulatory and financial pressures on both poultry integrators and growers make business success more challenging than ever, Provia Prime holds great promise for poultry producers. Healthier birds which are better able to withstand the stress of pathogens can help reduce costs of production, increase potential return on investment and help ensure plentiful and affordable protein for consumers.

Provia Prime (Pathogen Present)

Lesions from Pathogens

Presence of lesions in the bird indicate the bird is under stress. Stress can come from many factors, including pathogens such as Clostridium perfringens, E.coli and Salmonella. The healthier the microbiome, the better able the bird is to withstand stress from pathogens. The optimized microbiome which resulted from feeding Provia Prime was shown in trials to help reduce lesions (Figure 4.).

Figure 4. Lesion Scores, Day 42

a,b Means differ significantly (P < 0.05) as determined by Least Significant Difference. Phibro Data, 2017.

Negative Control (No Pathogen Present) Positive Control (Pathogen Present)

a1.389 a2.000

-

4.000

6.000

8.000

10.000

12.000

14.000

Mo

rtal

ity

%, D

ay 0

-42

Provia Prime Trials: Mortality

12.037 b

0.156 0.250

-

0.500

0.750

1.000

1.250

1.500

1.750

2.000

2.250

Les

ion

Sco

res,

Day

42

Provia Prime Trials: Lesion Scores

2.078 a

0.350 ba

0.463

Provia™ Prime Helps Gut Microbiome FlourishProvia Prime is a new direct-fed microbial (DFM) for poultry that helps optimize an animal’s microbiome. A healthy microbiome can result in increased body weight and improved feed conversion and may also lead to lower mortality rates and reduced lesions and pathogens (such as Clostridium perfringens, E. coli and Salmonella) in commercial poultry production.

Provia Prime is in a class of Bacillus-based DFMs that have been shown to promote beneficial gut bacteria that can help improve immunity, foster gut health and act as natural growth promoters. Provia Prime helps the poultry industry meet growing consumer demand and maneuver increasingly complex regulations.

Unique Broad-spectrum Four-Bacillus CombinationProvia Prime is a proprietary combination of four powerful probiotic strains of Bacillus subtillis, Bacillus licheniformis, Bacillus coagulans and Bacillus amyloliquefaciens. Each individual Bacillus strain was selected for its individual ability to enhance the microbiome. The four strains were combined to create a product with synergistic effects that enhance and diversify the microflora. Provia Prime contains a broad spectrum of diverse microbes that encourage a higher population in the gut of “good bacteria” known to support broiler health and increase yield.

Durable Stability and SurvivabilityProvia Prime offers superb heat stability and a long shelf life with no refrigeration requirement and is able to stand up to most manufacturing processes. Its high viability, along with a high survivability rate against gastric acidity and bile salts, allows Provia Prime to consistently enhance microflora even under challenging conditions, which in turn helps promote not only health, immunity and weight gain in poultry, but also potential increased return-on-investment for poultry producers.

Brought to You by Phibro Animal HealthProvia Prime is part of a family of products offered by Phibro Animal Health, a known and reliable advisor for nutritionists, feed mill operators and producers, globally. With a focus on providing dietary solutions to support customer needs, Phibro supports Provia Prime with its Dynamic Quality Assurance® (DQA®) Program and the Phibro technical support team.

How Provia Prime Works Direct-fed microbials are live microorganisms which, when fed at appropriate and regular quantities, support healthy microflora which, in turn, can confer health benefits for the animal. DFMs enable modification of the microbial population in the bird’s gut by promoting favorable microflora and reducing the presence of unfavorable microflora. A healthy microflora is the first line of defense against invading pathogens and extremely important in the ability to fight off infections with enteric pathogens. The Bacilli spores used in Provia Prime survive stomach acid when taken orally, readily germinate in the intestines and colonize for seven to 21 days before being excreted.

Provia Prime DevelopmentThe Phibro research and development team conducted a global search for the best microbiome-enhancing microbes within the genus Bacillus. All Bacilli were tested both in vitro and in vivo for their ability to support the growth of good bacteria that can help reduce pathogenicity and improve production.Once the ideal Bacilli were selected based on their individual performance, a combination was selected and tested to determine the ratio for each organism in the blend. Finally, the total CFUs per ton of complete feed were titrated for best performance feeding level.

In all trials, the final feeding rate yielded 5.3 x 105 CFUs per gram of final feed.

Provia Prime Clinical Trial Results

Testing of animals fed Provia Prime analyzed the following:

• Broiler body weights

• Feed conversion

• Mortality

• Lesions from pathogens

Feed Conversion

In the presence of pathogens, trials show that improvements to the microbiome when feeding Provia Prime delivered five percent better feed conversion rates (Figure 2.).

Figure 2. Feed Conversion, 0-42 Days

Figure 1. Average Body Weight, Day 42

Average Broiler Weights

In the presence of Clostridium perfringens, E. coli and Salmonella, broilers fed Provia Prime were 15.7 percent heavier (Figure 1.), essentially the same result as when no pathogens were present.

a,b Means differ significantly (P < 0.05) as determined by Least Significant Difference. Phibro Data, 2017.

Negative Control (No Pathogen Present) Positive Control (Pathogen Present) Provia Prime (Pathogen Present)

2,799 a 2,788 a

2,381 b

2,100

2,200

2,300

2,400

2,500

2,600

2,700

2,800

2,900

Ave

rag

e B

od

y W

eig

ht

(gra

ms)

, Day

42

Provia Prime Trials: Average Body Weight

1.846 a

1.78

1.8

1.82

1.84

1.86

1.88

1.9

1.92

1.94

1.96

1.98

Fee

d C

on

vers

ion

Co

rrec

ted

, Day

0-4

2

Provia Prime Trials: Feed Conversion

1.953 b

1.858 a