Editor in Chief: Rong Tian (Seattle, USA) Deputy Editor: Michael Regnier (Seattle, USA) Associate Editors: Johannes Backs (Heidelberg, Germany) Jennifer Davis (Seattle, USA) Isabelle Deschenes (Columbus, USA) Roger S.Y. Foo (Singapore) Ana M. Gomez (Paris, France) Rebekah Gundry (Omaha, USA) Asa Gustafsson (San Diego, USA) Jolanda van der Velden (Amsterdam, Netherland) Yibin Wang (Los Angeles, USA) Huang-Tian Yang (Shanghai, China) Wolfram-Hubertus Zimmermann (Göttingen, Germany) Ming-Hui Zou (Atlanta, USA) Rong Tian, MD, PhD, Professor and Director of Mitochondria and Metabolism Center at University of Washington, Seattle. Dr. Tian received her MD from the West China University of Medical Sciences and her PhD in Pharmacology from Aarhus University in Denmark. She is a world leader of myocardial energetics and metabolism. Her laboratory has made seminal contributions to the field by combining the multi-nuclear NMR spectroscopy of genetically engineered mouse models with the powerful technology of genomics, proteomics and metabolomics. Dr. Tian’s recent work on NAD metabolism, protein acetylation and mitochondrial stress response has yielded a major stimulus to the translational research as heart failure becomes a predominant diagnosis in our aging and obese population. Among the honors received, Dr. Tian is a fellow of the ISHR and a recipient of ISHR Research Achievement Award (2017), Distinguished Achievement Award of the American Heart Association Basic Science Council (2010) and Berne Distinguished Lecturer of the American Physiological Society (2019). She has been members of multiple editorial boards including the JMCC. She has also served as Section Editor for Circulation (2006-09), Consulting Editor for Circulation Research (2016-2019) and Academic Editor for PloS Biology (2013-present). Michael Regnier, PhD, Professor of Bioengineering and Physiology & Biophysics, and Director of the Center for Translational Muscle Research at the University of Washington, Seattle. Dr. Regnier received his PhD in Neurobiology at the University of Southern California. He is internationally recognized for his expertise in myofilament regulation of striated muscle contraction, and dysfunction of these mechanisms with mutations in sarcomere proteins. His laboratory uses state of the art approaches for multi-scale quantitative and computational analysis of muscle structure and function. More recently he has made significant contributions to understanding the developmental maturation of human stem cell derived cardiomyocytes and fetal heart tissue. Dr. Regnier is a Fellow of the American Institute of Medical and Biological Engineering. He has served on the Editorial Boards of the Journal of Applied Physiology (1999-2006) the Archives of Biochemistry and Biophysics (2012-present) and the Journal of General Physiology (January 2018-present). Drs. Regnier (left) and Tian (right) outside their offices in the South Lake Union Campus of the University of Washington, Seattle. INTRODUCTION OF THE EDITORIAL TEAM e ˆ o s)
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INTRODUCTION OF THE EDITORIAL TEAM
Editor in Chief: Rong Tian (Seattle, USA) Deputy Editor: Michael Regnier (Seattle, USA)
Associate Editors:Johannes Backs (Heidelberg, Germany)Jennifer Davis (Seattle, USA) Isabelle Deschenes (Columbus, USA)Roger S.Y. Foo (Singapore)Ana M. Gomez (Paris, France)Rebekah Gundry (Omaha, USA)Asa Gustafsson (San Diego, USA)Jolanda van der Velden (Amsterdam, Netherland)Yibin Wang (Los Angeles, USA)Huang-Tian Yang (Shanghai, China)Wolfram-Hubertus Zimmermann (Göttingen, Germany)Ming-Hui Zou (Atlanta, USA)
Rong Tian, MD, PhD, Professor and Director of Mitochondria and Metabolism Center at University of Washington, Seattle. Dr. Tian received her MD from the West China University of Medical Sciences and her PhD in Pharmacology from Aarhus University in Denmark. She is a world leader of myocardial energetics and metabolism. Her laboratory has made seminal contributions to the field by combining the multi-nuclear NMR spectroscopy of genetically engineered mouse models with the powerful technology of genomics, proteomics and metabolomics. Dr. Tian’s recent work on NAD metabolism, protein acetylation and mitochondrial stress response has yielded a major stimulus to the translational research as heart failure becomes a predominant diagnosis in our aging and obese population. Among the honors received, Dr. Tian is a fellow of the ISHR and a recipient of ISHR Research Achievement Award (2017), Distinguished Achievement Award of the American Heart Association Basic Science Council (2010) and Berne Distinguished Lecturer of the American Physiological Society (2019). She has been members of multiple editorial boards including the JMCC. She has also served as Section Editor for Circulation (2006-09), Consulting Editor for Circulation Research (2016-2019) and Academic Editor for PloS Biology (2013-present).
Michael Regnier, PhD, Professor of Bioengineering and Physiology & Biophysics, and Director of the Center for Translational Muscle Research at the University of Washington, Seattle. Dr. Regnier received his PhD in Neurobiology at the University of Southern California. He is internationally recognized for his expertise in myofilament regulation of striated muscle contraction, and dysfunction of these mechanisms with mutations in sarcomere proteins. His laboratory uses state of the art approaches for multi-scale quantitative and computational analysis of muscle structure and function. More recently he has made significant contributions to understanding the developmental maturation of human stem cell derived cardiomyocytes and fetal heart tissue. Dr. Regnier is a Fellow of the American Institute of Medical and Biological Engineering. He has served on the Editorial Boards of the Journal of Applied Physiology (1999-2006) the Archives of Biochemistry and Biophysics (2012-present) and the Journal of General Physiology (January 2018-present).
Drs. Regnier (left) and Tian (right) outside their offices in the South Lake Union Campus of the University of Washington, Seattle.
INTRODUCTION OF THE EDITORIAL TEAM
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Meet JMCC’s Associate Editors
Jennifer Davis, PhDUniversity of Washington
Dr. Davis is an Assistant Professor of Pathology and Bioengineering and the Director of
the Center for Cardiovascular Biology at the University of Washington. She earned her
PhD in Molecular & Integrative Physiology at the University of Michigan, followed by
postdoctoral training in the Heart Institute at the Cincinnati Children’s Hospital Medical
Center. In 2014, Dr. Davis won the Louis N. & Arnold M. Katz Basic Science Research Prize
from the American Heart Association. Currently, her laboratory utilizes interdisciplinary
approaches that include mouse genetics, cellular engineering, and transcriptomics to
examine the mechanistic basis for striated muscle and extracellular matrix remodeling
and cardiac wound healing. Her specifi c areas of expertise include striated muscle and
fi broblast physiology as well as muscle remodeling and fi brosis.
Isabelle Deschênes, PhDThe Ohio State University
Isabelle Deschênes, PhD is Professor and Chair, Department of Physiology and Cell Biology at
The Ohio State University. Dr. Deschênes received her PhD from Laval University in Quebec
City, Canada and did her post-doctoral training at Johns Hopkins University. She is recognized
for her work on the molecular mechanisms of arrhythmias. Her work combines the use of
molecular and electrophysiological techniques to study several inherited arrhythmias caused
by defects in ion channels such as Long QT and Brudada Syndrome and more commons forms
of arrhythmias due to acquired disease states such as heart failure. Her work also focuses on
the study of the genotype-phenotype discordance observed in several inherited arrhythmias.
Results obtained from her translational research focus on incomplete penetrance in inherited
arrhythmias have also been applied to a more basic focus allowing her to make fundamental
fi ndings on ion channels structure, assembly, traffi cking and transcriptional regulation all of
which contribute to the development of arrhythmias. Her lab also has extensive experience
studying the regulation of ion channels by miRNAs and transcriptional regulation of ion
channels. She has served on several editorial boards including JMCC and the Heart Rhythm
Journal.
Roger Foo, MD, MBBSNational University of Singapore (NUS)
Dr. Foo is a Professor of Medicine at the National University of Singapore (NUS), Senior
Group Leader at the Genome Institute of Singapore and Senior Consultant lead for the
Cardiac Genetics Clinic, National University Heart Centre. He is a graduate of the Medical
School at NUS, and spent 20 years abroad before returning to Singapore in 2013. His
specialist training was undertaken at Kings College Hospital, London, and Addenbrooke’s
Hospital, Cambridge. He was awarded the UK Wellcome Trust Fellowship to pursue post-
doctoral research at the Albert Einstein College of Medicine, New York, and returned
to Cambridge as a British Heart Foundation Fellow and Consultant Physician, before
eventually returning to Singapore. His lab was the fi rst to publish an epigenomic map
of the failing human heart in 2012. More recently, his lab has published an in-depth
analysis of the cardiac chromatin 3D organisation, and also reported the discovery of
a long noncoding RNA, called Singheart, which regulates key cardiac gene expression.
The approach of the lab is to deep dive into the epigenome of the heart, using advanced
technology including single cell transcriptomics and Crispr-genome editing to explore
frontiers, in continuing aspirations to discover novel avenues for therapies or biomarkers. Roger is also a keen advocate for
the application of genomics to the clinic. He leads the BMRC Rare Disease research programme, SUREkids. SUREkids has
developed a clinical whole exome sequencing pipeline which is ready for clinical use in Singapore and regionally.
Ana M Gómez, PhD, PharmDUniversité Paris-Saclay
Ana M. Go�mez, PhD, PharmD is the Director of Research at INSERM and Chair of the
Laboratory “Signaling and Cardiovascular Pathophysiology”, Université Paris-Saclay. Dr.
Gómez is an internationally-recognized expert in excitation-contraction coupling and cardiac
calcium signaling. Her laboratory uses multidisciplinary and state of the art approaches at
the molecular, cellular, and intact animal level for an integral study of physiological and
pathophysiological signaling in the heart. She pioneered in the study of elementary calcium
signals (calcium sparks) in animal models of heart failure, genetic ventricular tachycardia, and
in methods to analyze intracellular calcium signaling in pacemaker cells in situ. The aim of
Dr. Gómez’s work is to elucidate the roles and the mechanisms of Ca2+ fl ux alterations in
cardiac pathologies focusing on established heart failure, hypertrophy/heart failure initiation
and on the origin of arrhythmia. Among the honors received, Dr. Gómez is a fellow of the
ESC and the ISHR. She has served on the Editorial Boards of Cardiovascular Research (from
2013), Journal of General Physiology (from 2015), JMCC (from 2017), council of the Biophysical
Society (2006-2009), and is actually chair-elect of the ESC European Working Group on
Cellular and Cardiac Electrophysiology and co-chair of the Gordon Research Conferences on
Muscle: Excitation-Contraction Coupling.
Meet JMCC’s Associate Editors
Johannes Backs, MDHeidelberg University
Johannes received his MD degree from Heidelberg University in 2002 and was trained as a clinician from 1998-2003 in the Center of Internal Medicine at Heidelberg University Hospital. He was then trained as a postdoctoral fellow in the Department of Molecular Biology of UT Southwestern in Dallas from 2003-2007 (with Eric N. Olson). After leading an Emmy Noether Junior Research Group in Heidelberg from 2007-2013, Johannes was in 2013 appointed as a W3-Professor of the German Centre for Cardiovascular Research (DZHK) and in 2015 promoted to the Director of the Department of Molecular Cardiology & Epigenetics at Heidelberg University Hospital. In 2018, he became the inaugural Executive Director of the newly established Institute of Experimental Cardiology at Heidelberg University Hospital. Johannes’ group made discoveries in the fi elds of cardiac gene regulation and metabolism. For instance, his work has collectively demonstrated that lipid droplet-associated enzymes regulate histone deacetylases controlling the level of glucose metabolites, subsequently calcium handling and eventually cardiac function. Based on these fi ndings, translational projects on gene therapy and small molecules are ongoing. Johannes was recently elected as the spokesperson of the German Centre for Cardiovascular Research (DZHK) partner site Heidelberg/Mannheim, and he serves as the spokesperson of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC), as an HFA board member and as an at-large council member of the International Society of Heart Research (ISHR). He is JMCC associate editor since 2017.
Rebekah Gundry, PhDUniversity of Nebraska Medical Center
Rebekah L. Gundry, PhD, FAHA, is Professor and Vice Chair of Cellular and Integrative Physiology, Assistant Chief of Basic and Translational Research in the Division of Cardiovascular Medicine, and Director of the CardiOmics Program at the University of Nebraska Medical Center in Omaha, NE. Dr. Gundry received her PhD from Johns Hopkins University School of Medicine. Dr. Gundry is a leader in applied mass spectrometry technologies for cardiovascular research. Her laboratory develops and applies innovative mass spectrometry and bioinformatics approaches to study cell surface proteins and glycans to answer outstanding questions in stem cell and cardiac biology and disease. Major areas of focus include the development of reagents and methodologies to improve the quality of stem cell-derived cardiomyocytes for research and clinical applications, and identifi cation of cell type-specifi c targets for the development of new therapeutic strategies to treat heart failure. Among the honors received, Dr. Gundry is a fellow of the American Heart Association and recipient of the Robert J Cotter Young Investigator Award from the US Human Proteome Organization (USHUPO) (2013). She is currently on the Board of Directors for USHUPO and is Co-Chair of the HUPO Human Proteome Project Cardiovascular Initiative. She has served on the editorial board of Proteomics (2014-2017), and Clinical Proteomics (2019 – Present).
Åsa Gustafsson, PhDUniversity of California San Diego
Åsa Gustafsson received her PhD in Biomedical Sciences from the University of California San Diego in 2001. She did her Postdoctoral Fellowship (2001-2005) at The Scripps Research Institute in La Jolla. She is currently a Professor in the Skaggs School Pharmacy and Pharmaceutical Sciences at the University of California San Diego and the Chair of the Biomedical Sciences Graduate Program. Her research is focused on understanding the molecular pathways that regulate mitochondrial structure, function and turnover in the heart. Current research is focused on a) examining how the E3 ubiquitin ligase Parkin and mitophagy receptors (BNIP3, NIX, FUNDC1) regulates removal of mitochondria in cells; and b) determining the molecular mechanisms by which BCL-2 family proteins regulate mitochondrial function, morphology and turnover in cells. Dr. Gustafsson has received several awards such as the Outstanding Investigator Award from the International Society for Heart Research and the Established Investigator Award from the American Heart Association. Her research is supported by the National Institutes of Health and the Tobacco Related Disease Research Program.
Jolanda van der Velden, PhDAmsterdam University Medical Center
Prof. Jolanda van der Velden is chair of the Department for Physiology at the Amsterdam University Medical Center, and director of the Amsterdam Cardiovascular Sciences Institute. The main research interest of the van der Velden group is to study the role of sarcomere proteins in cardiac performance for which specifi c protein analyses and functional assays have been designed. As mutations in sarcomere proteins are a frequent cause of heart disease at young age, research on this topic was initiated with European and prestigious national grants. The national CVON-consortium (DOSIS) funded by the Netherlands Heart Foundation aims to study genetic and environmental effects in cardiomyopathy development. Studies on the genetic heart disease hypertrophic cardiomyopathy include basic cell and tissue analyses, which are combined with in vivo cardiovascular imaging in mouse models and human patients. The translational research projects help to build suffi cient proof to initiate clinical trials to prevent disease at an early stage of cardiomyopathy. In 2017 van der Velden received the Outstanding Investigator Award of the International Society for Heart Research (ISHR), and in 2018 she research a prestigious VICI grant from the Netherlands Organization for Scientifi c Research (NWO-ZonMW). Van der Velden actively participates in the international ISHR.
Meet the Associate Editors
Yibin Wang, PhDDavid Geffen School of Medicine, University of California Los Angeles
Dr. Yibin Wang is currently a full Professor of Molecular Medicine in the Department of Anesthesiology and Perioperative Medicine at David Geffen School of Medicine, UCLA. Dr. Wang received his Ph.D. in molecular genetics and cell biology from Baylor College of Medicine and post-doctoral training in neurobiology and molecular cardiology at The Scripps Research Institute and University of California at San Diego. Dr. Wang’s research mainly focuses on genetic and molecular mechanisms of heart failure and metabolic disorders. Dr. Wang received an Established Investigator Award from American Heart Association and was the recipient of Thomas Smith Memorial Lecture award at 2016 American Heart Association Scientifi c Session. He currently serves as an Associate Editor for Journal of Molecular and Cellular Cardiology, a guest Associate Editor for Circulation, and a member of the editorial board for Circulation Research and Journal of Biological Chemistry. He has served in more than 30 Ph.D. thesis committees, and is currently the course director and Vice Chair of the Molecular, Cellular and Integrated Physiology Ph.D. program at UCLA.
Huangtian Yan, MD, PhDShanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Huangtian Yang, MD, PhD, is Professor and Head of Laboratory of Molecular Cardiology at Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. Dr. Yang received her MD from Nantong Medical College and her PhD from Yamagata University School of Medicine. She is internationally recognized for her expertise in the cardioprotection, and the cardiac lineage commitment of pluripotent stem cells (PSCs) as well as their application in cardiac repair. Her laboratory uses state of the art approaches for analyzing Ca2+ signals, epigenetic modifi cations, mitochondrial and cardiac function in cardiac lineage commitment and cardioprotection. More recently she has made signifi cant contributions to promote the cardiac differentiation of PSCs and their roles and mechanisms in promoting infarct healing, and understand the mechanisms underlying intermittent hypoxia-mediated cardioprotection. Dr. Yang is a fellow of the ISHR. She has been served on the editorial boards for multiple journas including Acta Pharmacol. Sinica (2008-present), AJP-Heart Circ (2014-present), and Cell Death & Disease (2011-present). She has served as Associate Editor of the JMCC since 2017 and also served as Executive Editor of Pfl ügers Archiv – Eur J Physiol (2018-2021).
Wolfram-Hubertus Zimmermann, MDUniversity Medical Center, Georg-August-University
Wolfram-Hubertus Zimmermann, MD, is Professor of Pharmacology, and Director of the Institute of Pharmacology and Toxicology at the Un iversity Medical Center, Georg-August-University in Göttingen. He studied Medicine at the University Medical Center Hamburg-Eppendorf, DUKE University Medical School in Durham, Harvard Medical School in Boston, and the University of Cape Town. He graduated from Medical School in Hamburg, Germany, in 1998 and earned his doctorate from the University of Hamburg in 2000. In parallel, Dr. Zimmermann completed a second academic degree in Molecular Biology at the University of Hamburg in 2001. He trained at the Institutes of Experimental and Clinical Pharmacology and Toxicology at the Friedrich-Alexander University in Erlangen and the University Medical Center Hamburg-Eppendorf, where he was promoted to the rank of Junior professor in 2003. Dr. Zimmermann completed his training in Pharmacology and Toxicology in 2006 (board certifi cation) and was awarded the Venia Legendi (and Habilitation) in Pharmacology and Toxicology in 2007. He was appointed to his current position at the Georg-August-University in Göttingen in 2008. Dr. Zimmermann’s research interests include novel pharmacological and cell-based approaches to repair failing organs with a special emphasis on tissue engineered heart repair. Since 2011, Dr. Zimmermann is the speaker of the Göttingen partner site of the German Center for Cardiovascular Research (DZHK). He also serves as a clinical consultant in pharmacology and toxicology and reviewer for numerous journals and granting agencies. Dr. Zimmermann has published >150 articles and book chapters (H-index: 45) and is an inventor of several patents on different aspects of myocardial tissue engineering, stem cell biology, phenotypic drug screens, and innovative therapy development. He founded myriamed GmbH (2012) and Repairon GmbH (2014) to accelerate the development of innovative drugs and translate tissue engineered organ repair.
Ming-Hui Zou, MD, PhDGeorgia State University
Ming-Hui Zou, M.D. Ph.D. is the founding director, the Center of Molecular and Translational Medicine, and the Associate Vice President for Research, Georgia State University. Dr. Zou performed elegant, state of the art, studies to show that the selective modifi cation of two key proteins, prostacyclin synthase and endothelial nitric oxide synthase, is critical in the dysregulation of v essel function from nitric oxide and superoxide. Dr. Zou’s group was also the fi rst to demonstrate that the AMP-activated kinase (AMPK), a key enzyme in the regulation of energy metabolism, obesity, diabetes, and cardiovascular diseases, functions as a redox sensor and modulator of oxidative stress in cardiovascular systems. Finally, Dr. Zou has systemically studies how LKB1 or AMPK becomes dysfunction in both cardiovascular diseases and cancers and how dysfunctional LKB1/AMPK promotes cardiovascular disorders. Dr. Zou’s contributions in this area are important and his work represents outstanding breakthroughs research which has been recognized by many other investigators in the fi elds. Dr. Zou has served the editorial boards of many prestigious journals including J. Clin. Invest., Circulation Circulation Research, etc. In 2008 he was elected to the American Society for Clinical Investigation. Dr. Zou is the eminent scholar in Georgia Research Alliance since 2015.
Meet the Consulting Editors
Tohru Fukai, MDMedical College of Georgia at Augusta University
Tohru Fukai received his MD in Kyushu University School of Medicine, Fukuoka, Japan and then his PhD in Cardiovascular Physiology in 1995. He then joined Emory University School of Medicine, GA, USA as a postdoctoral fellow in the laboratory of Dr. David Harrison to study the role of extracellular SOD (SOD3) in cardiovascular disease and then promoted to Assistant Professor in 1999. He moved to the University of Illinois at Chicago, Division of Cardiology in 2006 as an Associate Professor and promoted to Professor in 2014. Since 2017, he has been at Medical College of Georgia at Augusta University as the Barbara A. Schnuck Professor of Vascular Biology Center/Pharmacology & Toxicology. His research interest focuses on a role of oxidative stress, copper transport system, and their crosstalk in cardiovascular and metabolic diseases and cancer to develop new therapeutic strategies. In particular, he is interested in antioxidant Cu enzyme SOD3 and its regulator Cu uptake transporter CTR1, Cu chaperone/transcription factor Atox1 and Cu transporter ATP7A. He joined JMCC Editorial Board in 2016 and Consulting Editor in 2020.
Francis Kim, MDUniversity of Washington
Francis Kim is currently the Kenneth Cooper Professor in Preventive Cardiology at the University of Washington and is a member in the UW Diabetes Institute and Center for Cardiovascular Biology. He is a graduate of University of California, Berkeley where he majored in Chemistry and went to medical school at the University of California, San Francisco. The Kim lab focuses on endothelial biology, nitric oxide signaling, and the interaction of immune cells with the endothelium.
MEET OUR SENIOR CONSULTING EDITORS
Andrew H. Baker, BSc (Hons), PhD, FMedSci, FRSE
BHF Professor of Translational Cardiovascular SciencesGustav Born Chair of Vascular BiologyHead of Centre for Cardiovascular ScienceUniversity of Edinburgh
E. Douglas Lewandowski, PhD
Jack M. George Chair in MedicineDirector, Translational Research,Dorothy M. Davis Heart & Lung Research Instituteand Professor, Department of Internal Medicine The Ohio State University College of Medicine
Manuel Mayr, MD, PhD
Professor of Cardiovascular ProteomicsBritish Heart Foundation Centre of Research Excellence,King’s College London
Elizabeth McNally, MD, PhD
Ward Professor and DirectorCenter for Genetic MedicineNorthwestern University Feinberg School of Medicine
Corrado Poggesi, MD
Professor of PhysiologyHead of the Department of Experimental and Clinical MedicineUniversity of Florence
Professor and Canada Research ChairInstitute of Biomaterials and Biomedical EngineeringAssociate Chair-ResearchDepartment of Chemical Engineering and Applied ChemistryUniversity of TorontoSenior ScientistToronto General Research Institute
Junichi Sadoshima, MD, PhD
Professor and Chair of the Department of Cell Biology and Molecular MedicineRutgers New Jersey Medical School
R. John Solaro, PhD
Distinguished University ProfessorBoard of Directors Center for Cardiovascular ResearchDept Physiology and BiophysicsCollege of Medicine, University of Illinois at Chicago
