INVENTIVE SOLUTIONSFOR OUTSTANDING RESULTSSOFT TISSUE IMPLANTS FOR DERMAL INJECTION
CE Class III Medical Device
RRS® Hyalift® 35 RRS® Hyalift® 75 RRS® Hyalift® 75 Proactive
RRS® HA Injectable RRS® HA Tensor Lift
RRS® HA Skin Relax with BoNtA 568®
RRS® Silisorg RRS® Silisorg HA RRS® Silisorg Tensor
RRS® HA Whitening RRS® HA Strimatrix RRS® HA Cellutrix
XL Hair®
RRS® HA Eyes
RRS® UNIQUE FORMULATIONSTailored to each indication, for face & bodyEasy to use & approved protocolsOne product - One treatmentQuick responseStable & durable results Compatible with other products & methodsCost effective
INNOVATIONRRS® HYDRO-BOOSTERSUSE THE VALUABLE SUBSTANCE UP TO THE LAST DROP
3 mLsyringe
Intensive Rejuvenation
In-Depth Hydrobalance
Inhibits Dermal Atrophy
PRODUCT
RRS® HYALIFT® 35RRS® HYALIFT® 75RRS® HYALIFT® 75 PROACTIVE
RRS® HA INJECTABLERRS® HA SKIN RELAX with BoNtA 568®
RRS® HA TENSOR LIFTRRS® HA WHITENINGRRS® HA EYESRRS® HA STRIMATRIXRRS® HA CELLUTRIX
XL HAIR®
RRS® SILISORGRRS® SILISORG HARRS® SILISORG TENSOR
DERMAL IMPLANT
REPAIRS | REFILLS | STIMULATES
DESCRIPTION
7 mg/mL non cross-linked Hyaluronic Acid15 mg/mL non cross-linked Hyaluronic Acid15 mg/mL non cross-linked Hyaluronic Acid + Aminoacids & Resveratrol
6 mg/mL non cross-linked Hyaluronic Acid + anti photo aging A.S.1 mg/mL non cross-linked Hyaluronic Acid + relaxing A.S.6 mg/mL non cross-linked Hyaluronic Acid + tensing A.S.1 mg/mL non cross-linked Hyaluronic Acid + anti pigment effect A.S.5 mg/mL non cross-linked Hyaluronic Acid + for eyes contouring A.S.2 mg/mL non cross-linked Hyaluronic Acid + stretch marks A.S.0.5 mg/mL non cross-linked Hyaluronic Acid + panniculopathy A.S.
0.001 mg/mL non cross-linked Hyaluronic Acid + alopecia A.S.
200 mg/mL Organic Silicium + antioxidant A.S. (Resveratrol)50 mg/mL Organic Silicium + 2 mg/mL non cross-linked Hyaluronic Acid + antioxidant A.S. (Resveratol)25 mg/mL Organic Silicium + tensing effect A.S.
DERMAL IMPLANT ANCILLARY SOLUTION (A.S.)
HASiOrgORGANIC SILICIUM
HYALURONIC ACID &/or
Dermal implant for photo aging and its consequences
Skin rejuvenation +Hydrobalance +Dermal atrophy +
COMPOSITIONHA, non-cross-linked 7,0 mg/mL (35 mg/5 mL)
Dermal implant for photo agingand its consequences
Skin rejuvenation ++Hydro balance +++Dermal atrophy ++
COMPOSITION HA, non-cross-linked 15,0 mg/mL (75 mg/5 mL)
Dermal implant for photo aging and its consequencesIntercellular matrix revitalization
Skin rejuvenation +++Dermal atrophy +++
COMPOSITION HA, non-cross-linked 15,0 mg/mL (75 mg/5 mL)Amino acids, Polyphenols, Antioxidants
Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vials Syringe containing 3 mL (0,1 fl.Oz)Box of 1 / 2 / 4 syringes
Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vialsSyringe containing 3 mL (0,1 fl .Oz) Box of 1 / 2 / 4 syringes
Vials containing 5 mL (0,175 fl.Oz)Box of 2 vials / 6 vialsSyringe containing 3 mL (0,1 fl .Oz) Box of 1 / 2 / 4 syringes
08/09
5 mL
3-5 mL
Injections mapping for face & neck, décolletéwith RRS® Hyalift
Learn more on www.rrs-inject.com/medinet
06/07
RR
S® H
YALI
FT®
35R
RS®
HYA
LIFT
® 7
5R
RS®
HYA
LIFT
® 75
PR
OA
CTIV
E
Dermal implant for photo aging and its consequences
Skin rejuvenation +Hydrobalance +Dermal atrophy +
COMPOSITIONHA, non-cross-linked 7,0 mg/mL (35 mg/5 mL)
Type of injection Microdermal: 30G needle, 3 mL (face) / 3-5 mL (décolleté)Deep dermal:25G or 27G cannula - 5 mL (face)
Frequency 1 session per week · 1 protocol = 4 sessions average
Maintenancerepeat protocol 1-3 times a year
Best combinationRRS® Hyalift + RRS® Silisorg & RRS® Silisorg Tensor
RRS® Hyalift 75
RRS® Hyalift 35
Dermal implant for skin photo aging and dermal atrophy
COMPOSITIONHA, non-cross-linked 6,0 mg/mL (30 mg/5 mL)Organic SiliciumFlavonoids (Hesperidin, quercetin)Vitamins (Vit B-C-F, etc)Antioxidants (Phytic, lipoic acid, etc)Aminoacids (Valine, Taurine, etc)Polyphenols (Viniferins, Resveratrol, etc)Trace elements (Cu, Zn, Co, etc)Coenzymes (NAD, NADP)
Dermal implant for dermal laxityDermal tensing effect
COMPOSITIONHA, non-cross-linked 6,0 mg/mL (30 mg/5 mL)Organic SiliciumFlavonoids (Hesperidin, quercetin)DMAE 0,5%Vitamins (Vit B-C-F, etc)Antioxidants (Phytic, lipoic acid, etc)Aminoacids (Valine, Taurine, etc)Polyphenols (Viniferins, Resveratrol, etc)Trace elements (Cu, Zn, Co, etc)Coenzymes (NAD, NADP)
Vials containing 5 mL (0,175 Fl. Oz)Box of 2 vials / 6 vials
Vials containing 5 mL (0,175 Fl. Oz)Box of 2 vials / 6 vials
Dermal implant for skin photo agingAnti pigmentation effect
COMPOSITIONHA, non-cross-linked 1 mg/mL (3 mg/3 mL)Arbutin, Aminoethylphosphinic Acid, Retinyl Palmitate, Morus Alba extract, Licorice extract, Vit C, Glycyrrhiza glabra extract, etc.Vitamins (Vit A-C-E, etc)
Vials containing 3 mL (0,10 Fl. Oz)Box of 2 vials / 6 vials
08/09
RR
S® H
A IN
JECT
AB
LER
RS®
HA
TEN
SOR
LIF
TR
RS®
HA
WH
ITEN
INGType of injection
Microdermal / Deep dermal
Frequency 1 session per week · 1 protocol = 6 sessions averageMaintenance repeat protocol 1-3 times a yearBest combination RRS® HA Skin Relax for upper face RRS® HA Eyes for eye contourRRS® HA Injectable + RRS® Silisorg Tensor for photo aging treatment + dermal densification
Injections mapping for face & neck, décolleté with RRS® HA Injectable, RRS® HA Tensor Lift,RRS® HA Whitening
3 mL
RR
S® HA Tensor Lift
RR
S® HA Whitening
3-5 mL RR
S® HA Injectable
3-5 mL
Learn more on www.rrs-inject.com/medinet
Max distance between injection points: RRS® HA Tensor Lift 2 cmRRS® HA Injectable 1 cm
RRS® HA Whitening 0.5 cm
RRS® HA Tensor Lift: 0.1 ml/ injection point RRS® HA Injectable: 0.1 ml/ injection point
RRS® HA Whitening: 0.05 ml/ injection point
PRIZE
Dermal implant for area around the eyesMicrocirculatory enhancement
COMPOSITIONHA, non-cross-linked 5,0 mg/mL (7,5 mg/1,5 mL)Organic SiliciumAntioxidants (Vit C, Resveratrol, etc)Flavonoids (Troxerutin, Hesperidin, etc)Saponins (Ruscogenin, Escin, etc)Polyphenols (Viniferin, Coumarin, etc)Peptides (Dipeptide VW, Pal-GQPR)
Ampoules containing 1,5 mL (0,05 fl. Oz)Box of 2 ampoules / 12 ampoules
Dermal implant for photo aging associated with excessive skin tensionRelaxing effect
COMPOSITIONHA, non-cross-linked 1,0 mg/mL (3 mg/3 mL)Oligopeptides: Pentapeptide-18, Acetyl Hexapeptide-8, Acetyl octapeptide-3
Facial expresions areasAlternative treatment
Vials containing 3 mL (0,10 fl. Oz)Box of 2 vials / 6 vials
RRS® HA Eyes - Best injectableproduct for eye areaWinner 2014 in category “Aesthetic Dermatology”Polish Society Aesthetic Dermatology
Top product in safety and effectiveness More than 4.500 in Poland have cast their vote to RRS® HA Eyes
2014
10/11
RR
S® H
A E
YES
RR
S® H
A S
KIN
REL
AX
WIT
H B
oNtA
568
®
Injections mapping for face & neck, décolletéwith RRS® HA Eyes, RRS® HA Skin Relax
Type of injection Microdermal / Deep dermal
Frequency 1 session per week · 1 protocol = 4 sessions average
Maintenancerepeat protocol 1-3 times a year
Best combinationRRS® Skin Relax + RRS® Hyalift 35/75 for neck and décolletéRRS® HA Eyes can be combined with botulinic toxin
1,5 mLfor both eyes
RR
S® HA Skin Relax
5 mL
RRS® HA Eyes
Dermal implant for the treatment and filling of depressions caused by linear ruptures of stretch marks
COMPOSITIONHA, non-cross-linked 2 mg/mL (20 mg/10 mL)Organic SiliciumFibroblast Growth Factors (FGF)Aminoacids (Glycine, Isoleucine, Lisine, etc)Flavonoids (Quercetin, Kaempferol)Fatty acids (Linoleic, Oleic Acid)Vitamin CSodium DNA
Dermal implant for the treatment of Edematous Fibrosclerotic PanniculopathyStimulates microcirculation
COMPOSITIONHA, non-cross-linked 0,5 mg/mL (5 mg/10 mL)Antioxidants (Vit C, Triferulic Acid, etc)Flavonoids (Cinaroside, Quercetine, Rutin, etc)Vitamins (Vit A-B-C-E, etc)Saponins (Ruscogenin, etc)Fucoxanthin, Caffeine, L-carnitine, etc
Vials containing 10 mL (0,35 fl. Oz)Box of 2 vials / 6 vials
Vials containing 10 mL (0,35 fl. Oz)Box of 6 vials
I N J E CT I O N T E C H N I Q U E S
PAPULA LINEAR HORIZONTAL LINEAR VERTICAL
12/13
RR
S® H
A S
TRIM
ATR
IXR
RS®
HA
CEL
LUTR
IX
10mL
Type of injection Microdermal / Deep dermal
Frequency 1 session per week · 1 protocol = 6 sessions average
Maintenancerepeat protocol 1-3 times a year
Best combinationRRS® HA Strimatrix or RRS® HA Cellutrix + RRS® Silisorg / RRS® Silisorg Tensor
2/3 cm
2/3 cm
Injections mapping for body with RRS® HA Strimatrix & RRS® HA Cellutrix
Dermal implant for the treatment of skin laxity
COMPOSITIONOrganic Silicium 200 mg/mL (1000 mg/5 mL)Resveratrol
Dermal implant for the treatment of UV induced skin photo aging
COMPOSITIONOrganic Silicium 50 mg/mL (250 mg/5 mL)HA, non-cross-linked 2 mg/mL (10 mg/5 mL)Resveratrol
For delicate areas
Dermal implant for the treatment of UV induced skin photo aging and laxity
COMPOSITIONOrganic Silicium 25 mg/mL (125 mg/5 mL)DMAE 0,1%
Ampoules containing 5 mL (0,175 fl. Oz)Box of 12 ampoules
Ampoules containing 5 mL (0,175 fl. Oz)Box of 12 ampoules
Ampoules containing 5 mL (0,175 fl. Oz)Box of 2 ampoules / 12 ampoules
Neck: 5mlArea
Back: 5mlArea
Elbow: 2.5mlArea
Arm: 2.5mlArea
Dermal implant for the treatment of UV induced skin photo aging
COMPOSITIONOrganic Silicium 50 mg/mL (250 mg/5 mL)HA, non-cross-linked 2 mg/mL (10 mg/5 mL)Resveratrol
For delicate areas
14/15
RR
S® S
ILIS
OR
GR
RS®
SILI
SOR
G H
AR
RS®
SILI
SOR
G T
ENSO
R
Type of injection Microdermal / Deep dermal
Frequency 1 session per week · 1 protocol = 6 sessions average
Maintenance repeat protocol 1-3 times a year
Best combinationAny RRS® HA product for microdermal densificationRRS® Silisorg + RRS® Hyalift 35 / RRS® Hyalift 75
Injections mapping for neck, back, elbow and arm with RRS® Silisorg / RRS® Silisorg HA / RRS® Silisorg Tensor
2,5mL
5 mL
5 mL
0.1/0.2 mL / Injection point cm
RR
S® Silisorg Tensor
RRS® Silisorg
RRS® Silisorg HA
Dermal implant for alopecia and activation of hair restoration
COMPOSITIONHA, non-cross-linked 0,001 mg/mL (0,003 mg/ 3 mL) / (0,005 mg/ 5 mL)Organic SiliciumFibroblast Growth Factors (FGF)Copper peptide, deoxyribonucleic acidVitamins (B, H, etc)Flavonoids (Quercetin, etc)TerpenesAminoacids, Antioxidants
Vials containing 3/5 mL (0,10/0,75 fl. Oz)Box of 6 vials
Cells Human Hair dermal papilla cells
Culture plate 24 wells plate
(cellular) 15000 c/well
Culture Medium Mesenchymal stem cell medium +2,5% FBS
Cell synchronization 6 hours starvation
Cell activation Serum free medium +/- product dilution
Proliferation assay MTT assay
Result expression % cell viability = [OD (500mm - 690mm) test product/OD (500mm - 690mm) negative control] x 100
Replicates 3
In vitro study XL HAIR® Increases proliferation of human papilla cells IntroductionIn vitro test has been performed for efficacy assessment of the test product XL HAIR®, using Human Hair dermal papilla cells. The study was performed in Abich laboratory, located in Via 42 Martiri, 213/B - 28924 - Verbania - Italy.The experimentation was done in June 2014.
SummaryAn in vitro test has been performed on XL HAIR® for efficacy assessment on Human Hair dermal papilla cells. Cell proliferation following the exposure to the actives in particular conditions has been evaluated.Cell proliferation after starving at different end times through the MTT assay: cell viability assay using cultured dermal papilla cells from human hair follicles to assess the cell proliferation following exposure to the test sample.
On the basis of the tests carried out, under the adopted experimental conditions, the sample of the test substance,XL HAIR® is able to increase cells proliferationwith respect to untreated control cell cultures. The highest effect (+23.3%) is pointed out at 1mg/mL of active substance after an exposure period of 48 hours.
0.2 mg/ml 1 mg/ml
XL HAIR®
120
140
160
100
% c
ell v
iabi
lity
23% increase
XL HAIR® in vitro study XL HAIR® in vitro study
16/17
XL H
AIR
®
Before/After Before/After
XL HAIR® RESULTS
Clinical results by expert doctors. Skin Tech Pharma Group (Gabriel Siquier, Evgeniya Ranneva, Barbara Kubicka, Aleksandra Djordjevic, etc)
RRS® RESULTSBefore/After
Clinical results by expert doctors. Skin Tech Pharma Group (Diana Yudina, Evgeniya Ranneva, Nenad Stankovic, etc)´
RRS® HA Whitening
RRS® HA Tensor Lift, RRS® HA Eyes
RRS® HA InjectableRRS® Hyalift 35, RRS® Silisorg Tensor
RRS® Hyalift 75
RRS® Hyalift 75 Proactive, RRS® HA Eyes
Before/After
REP
AIR
& B
ALA
NC
Efo
r fa
ceBEST CHOICE in combination with RRS®
SPEC
IAL
CAR
EB
OD
Y &
HA
IR
Day Intensive RepairREJUVENATING COMPLEX
WITH HYALURONIC ACID + PEPTIDES
EyesBEAUTIFIES THE APPEARANCE
OF EYE CONTOUR
Night Intensive Repair RWITH RESVERATROL
Night Intensive Repair MWITH MELATONIN
Night Intensive Repair HWITH HYALURONIC ACID
Relax SkinREJUVENATION
POLY-OLIGOPEPTIDES + MOISTURIZING
Strimatix®
REDUCES THE APPEARANCEOF STRIAE DISTENSAE
Cellutrix®
REDUCES THE APPEARANCEOF ORANGE SKIN
ScalpFitPRE-TREATMENT
SCALP AND HAIR DEEP CLEANSING
RevitalixPOST-TREATMENT
SCALP & HAIR HYDRATION
HairHAIR GROWTH
SPRAY
Aclaranse®
REDUCES THE APPEARANCEOF PIGMENT IRREGULARITIES
Skin RetrievalPOST TREATMENT
SKIN RECOVERY
SKIN TECH PHARMA GROUP SLC/ Pla de l’Estany, 29 · 17486 Castelló d’Empúries · Girona (Spain)
[email protected] · www.skintechpharmagroup.comDISTRIBUTOR’S INFORMATION
To learn more about RRS®
protocols & techniques visit MEDINET
www.rrs-inject.com AD_C
ARRS
04www.rrs-inject.com