Date post: | 31-May-2015 |
Category: |
Health & Medicine |
Upload: | abino-david |
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Investigations
•Investigations should be guided by the clinical presentation.
•Any lymph node enlargement in neck that persists for more than 2 weeks suggests need for investigation.
•Localised lymph node enlargement usually does not need any investigations.
Full blood count/blood film
i. Useful for detecting some lymphoproliferative disorders, chronic lymphocytic leukaemia and atypical mononuclear cells associated with viral syndromes.
ii. The presence of anaemia (or other cytopaenias) suggest significant underlying illness
Serological Examination
i. Epstein-Barr virusii. Toxoplasma (IgM, IgG)iii. Dengue (IgM, IgG)iv. Cytomegalovirus (IgM, IgG)v. HIV
Investigations for underlying
autoimmune conditions
i. ANAii. Anti- dsDNAiii.Complement C3/C4iv. Rheumatoid factor
Biochemical tests
i. LDHii. Liver function testsiii. Calcium and phosphateiv. Uric acid
Other tests
i. ESR
ii. CRP
a. Chest x-ray
b. CT scan
c. Mammography
d. PET scan
Imaging
Invasive methods
Fine needle aspiration
Lymph node excision biopsy
Lymph node aspiration-
1% lignocaine0.2 ml normal saline
• FNA + cytomorphological evaluation + flow cytometry
Lymph node excision biopsy showing follicular lymphoma