INVESTOR PRESENTATIONNASDAQ/TSX - BLU

JANUARY 2021

Forward Looking Statements

2

Certain statements contained in this presentation, other than statements of fact that are independently verifiable at the date hereof, may constitute “forward-looking statements” within themeaning of Canadian securities legislation and regulations and other applicable securities laws. Forward-looking statements are frequently, but not always, identified by words such as “expects,”“anticipates,” “believes,” “intends,” “estimates,” “potential,” “possible,” “projects,” “plans,” and similar expressions. Such statements, based as they are on the current expectations of management,inherently involve numerous important risks, uncertainties and assumptions, known and unknown, many of which are beyond BELLUS Health’s control. Such statements include, but are not limitedto, the potential of BLU-5937 to successfully treat chronic cough, chronic pruritus and other hypersensitization-related disorders, BELLUS Health’s expectations related to its preclinical studies andclinical trials, including the design and timing of the Phase 2b clinical trial of BLU-5937 in refractory chronic cough and the Phase 2 clinical trial of BLU-5937 in chronic pruritus, the timing andoutcome of interactions with regulatory agencies, including with the FDA regarding the SOOTHE Phase 2b trial design, the potential activity and tolerability profile, selectivity, potency and othercharacteristics of BLU-5937 , including as compared to other competitor candidates, the commercial potential of BLU-5937, including with respect to patient population, pricing and labeling, andthe potential applicability of BLU-5937 and BELLUS Health’s P2X3 platform to treat other disorders. Risk factors that may affect BELLUS Health’s future results include but are not limited to: thebenefits and impact on label of its enrichment strategy, estimates and projections regarding the size and opportunity of the addressable refractory chronic cough market for BLU-5937, the ability toexpand and develop its project pipeline, the ability to obtain adequate financing, the ability of BELLUS Health to maintain its rights to intellectual property and obtain adequate protection of futureproducts through such intellectual property, the impact of general economic conditions, general conditions in the pharmaceutical industry, the impact of the COVID-19 pandemic on BELLUS Health’soperations, plans and prospects, including to the initiation and completion of clinical trials in a timely manner or at all, changes in the regulatory environment in the jurisdictions in which BELLUSHealth does business, stock market volatility, fluctuations in costs, changes to the competitive environment due to consolidation, achievement of forecasted burn rate, potential payments/outcomesin relation to indemnity agreements and contingent value rights , achievement of forecasted preclinical study and clinical trial milestones, reliance on third parties to conduct preclinical studies andclinical trials for BLU-5937 and that actual results may vary once the final and quality-controlled verification of data and analyses has been completed. In addition, the length of BELLUS Health’sproduct candidate’s development process and its market size and commercial value are dependent upon a number of factors. Moreover, BELLUS Health’s growth and future prospects are mainlydependent on the successful development, patient tolerability, regulatory approval, commercialization and market acceptance of its product candidate BLU-5937 and other products. Consequently,actual future results and events may differ materially from the anticipated results and events expressed in the forward-looking statements. BELLUS Health believes that expectations represented byforward-looking statements are reasonable, yet there can be no assurance that such expectations will prove to be correct. The reader should not place undue reliance, if any, on any forward-lookingstatements included in this presentation. These forward-looking statements speak only as of the date made, and BELLUS Health is under no obligation and disavows any intention to update publiclyor revise such statements as a result of any new information, future event, circumstances or otherwise, unless required by applicable legislation or regulation.

Please see BELLUS Health’s public filings with the Canadian securities regulatory authorities, including, but not limited to, its Annual Information Form, and the United States Securities andExchange Commission, including, but not limited to, its Annual Report on Form 40-F, for further risk factors that might affect BELLUS Health and its business.

Company Overview

BELLUS Overview

Well FinancedBLU-5937: Highly Selective P2X3 Antagonist for Hypersensitization Disorders

Key 2021 Milestones

Lead Indication - Refractory Chronic Cough (RCC)• Large patient population, estimated at 9m in U.S., with significant unmet need

• BLU-5937, a second generation highly selective P2X3 antagonist, has shown reduction in cough frequency in patients ≥20 coughs/h and limited taste side effects (≤10% of patients)

• First generation P2X3 antagonist in Phase 3, Merck’s MK-7264: reduces cough but leads to taste alteration/loss in 58-69% of patients1

• SOOTHE Phase 2b trial initiated in 4Q20

1McGarvey L., Two Phase 3 Randomized Clinical Trials of Gefapixant, a P2X3 Receptor Antagonist, in Refractory or Unexplained Chronic Cough (C1 & C2), ERS Abstract 2020

2 4 indications (pain related to endometriosis, overactive bladder, sleep apnea and neuropathic pain) in development by third parties

~$111M cash position3

Refractory chronic cough Phase 2b interim (mid-year) and topline (4Q)

Chronic pruritus Phase 2 topline (4Q)

3As of September 30th, 2020 and proforma to October 22, 2020 financing

Pipeline within a Molecule • Potential for broad applicability in hypersensitization disorders

• BLUEPRINT Phase 2 with BLU-5937 for chronic pruritus associated with atopic dermatitis initiated in 4Q 2020

• 5 non-cough indications in phase 2 with P2X3 antagonists2

Strong Leadership and Advisory GroupManagement

Roberto BelliniPresident & Chief Executive Officer

Dr. Denis Garceau Senior Vice President, Drug Development

Ramzi BenamarChief Financial Officer

Tony MatzouranisVice President, Business Development

Board of Directors

Dr. Francesco Bellini

Franklin BergerRoberto Bellini

Dr. Clarissa Desjardins

Joseph Rus

Dr. Youssef Bennani

Clinical Advisory Board

Dr. Surinder Birring, MB ChB (Hons), MDKing’s College London

Dr. Michael S. Blaiss, MDMedical College of Georgia

Dr. Peter Dicpinigaitis, MDAlbert Einstein Medical College

Dr. Jacky Smith (Chair) , MB, ChB, FRCP, PhDManchester University

5

Dr. Catherine BonuccelliChief Medical Officer

Chair

Pierre Larochelle

P2X3 Linked to Cough & Other Hypersensitization Disorders

6

P2X3 is an ATP gated ion channel in the peripheral sensory nervous system

• Urge to cough

PRIMARY IRRITATIVE SYMPTOMSOther Hypersensitization DisordersChronic Cough

◦ Urge to scratch◦ Pain◦ Allodynia◦ Allotussia

◦ Irritation◦ Interstitial cystitis

◦ Scratching◦ Overactive bladder◦ Hypertension

◦ Hyperreflexia carotid body

◦ GI hyperactivity

• Cough

SECONDARY AUTONOMIC REFLEXESOther Hypersensitization DisordersChronic Cough

BLU-5937: Pipeline Within a Molecule

7

PROGRAM DEVELOPMENT STATUS

Indication Preclinical phase 1 phase 2 phase 3 Worldwide Rights Next Anticipated Milestone

BLU-5937

Refractory Chronic Cough

Mid 2021: interim analysis

Q4 2021: top line data

Chronic Pruritus Associated with

Atopic DermatitisQ4 2021: top line data

Potential forBroad Applicability andBuilding Pipeline in a Product

PH2 TRIALS ONGOING OR PLANNED IN 5 NON-COUGH P2X3 INDICATIONS1

• CHRONIC PRURITUS

• OVERACTIVE BLADDER• ENDOMETRIOSIS

PAIN

• SLEEP APNEA• NEUROPATHIC

PAIN

• SLEEP APNEA

1Currently in active development

• NEUROPATHIC PAIN

• ENDOMETRIOSIS PAIN

Refractory Chronic Cough

9

Refractory Chronic Cough

Cough lasting ≥ 8 weeks that does not respond to treatment for underlying cause or is unexplained

Current approved treatment options are inadequate and non-specific

Significant impact on patients’ quality of life including impact on social, physical and psychosocial well-being

Large patient population1 - up to ~9M refractory chronic cough patients in the U.S. with ~3M patients coughing >1 year

1Company sponsored market research

Proof-of-Mechanism Illustrated by First-in-Class P2X3 Antagonist MK-7264

10

Reduces cough but withTaste Side Effects

18% & 15%Cough1

MK-7264

58% & 69%Taste AEs1

First generation P2X3 antagonist with low

selectivityplacebo adjusted reduction in 24H cough frequency (primary endpoint)

of patients have taste alteration or taste loss

Two Phase 3 Trials of Gefapixant: COUGH-1 (12 week duration) and COUGH-2 (24 week duration)

1McGarvey L., Two Phase 3 Randomized Clinical Trials of Gefapixant, a P2X3 Receptor Antagonist, in Refractory or Unexplained Chronic Cough (C1 & C2), ERS Abstract 2020

Lack of P2X3 Selectivity Likely Cause of Taste Side Effect

11

P2X3 and P2X2/3: ATP-gated ion channels that transmit sensory signals

TASTE:P2X2/3 heterotrimers may have major role in taste1

COUGH REFLEX:P2X3 homotrimers have primary role in cough1

OPPORTUNITY:Development of a highly selective P2X3 antagonist to reduce cough with limited taste side effects

1Bellus Internal Data; Dicpinigaitis et al (2020) P2X3-Receptor Antagonists as Potential Antitussives: Summary of Current Clinical Trials in Chronic Cough. Lung. 198: 609-616; Finger et al. (2005) ATP signaling is crucial for communication from taste bugs to gustatory nerves. Science 310(5753):1495-1499; Vanderbeuch A, Larson ED, Anderson CB, et al. (2015) Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice. J Physiol 593 (5):1113-1125.

BLU-5937: P2X3 Antagonist with High Selectivity

12

HIGHLY POTENT1

P2X3 antagonistLow nM IC50

HIGHLY SELECTIVE1

P2X3 antagonist~ 1500X selectivity vs P2X2/3

BLU-5937

CLINICALLY MEANINGFUL2

reduction in cough frequency in RCC patients ≥20 coughs/h

LIMITED taste side effects (≤10% of

patients)

1 IC 50 calculated using cloned hP2X3 and hP2X2/3 channels expressed in HEK295 cells; (Ca2+ FLIPR)2 BELLUS RELIEF Phase 2 Trial prespecified subgroup

PERIOD 1: 16-DAY DOSE ESCALATION

PERIOD 2: 16-DAY DOSE ESCALATION

Phase 2 RELIEFTrial Design

68 refractory chronic cough patients:52 completed dosing 13 pandemic-related discontinuations 3 non-drug related discontinuations

Primary endpoint:Placebo-adjusted reduction in awake cough frequency using cough recorder

16 sites in UK and US:40 patients from 8 UK sites28 patients from 8 US sites

4 dose levels:25/50/100/200mg BID with forced dose escalation at 4-day intervals

13

Cough Recording Conducted

(A Randomized, Double-blind, Placebo-

Controlled, Crossover, Dose Escalation

Study of BLU-5937 in Subjects with

Unexplained or Refractory Chronic Cough)

• RELIEF Phase 2 trial achieved proof of concept in reducing cough frequency in RCC patients including statistically significant reductions in pre-specified subgroup analyses of patients with ≥20 coughs/h and 32 coughs/h:• ITT population: 6-17% placebo-adjusted reduction in awake cough frequency (not statistically significant)• ≥20 c/hr : 18-27% placebo-adjusted reduction in awake cough frequency (p<0.032)• ≥32 c/hr : 28-32% placebo-adjusted reduction in awake cough frequency (p<0.0015)

BLU-5937: RELIEF PHASE 2 TRIAL PRIMARY ENDPOINT

14

PLACEBO-ADJUSTED CHANGE IN AWAKE COUGH FREQUENCY

-50% -30% -10% 10% 30%

BLU-5937 better Placebo better

Intent-To-Treat Population100% Trial Population

-11% 0.1424

-6% 0.4602

-8% 0.4181

-17% 0.0855

25 mg

50 mg

100 mg

200 mg

Placebo-Adjusted △ p-value

-50% -30% -10% 10% 30%

BLU-5937 better Placebo better

-20% 0.0010

-18% 0.0186

-19% 0. 0320

-27% 0.0026

Placebo-Adjusted △ p-value

≥ 20 c/h Population80% Trial Population

*

*

*

*

-50% -30% -10% 10% 30%

BLU-5937 better Placebo better

-28% 0.0005

-28% 0.0003

-30% 0. 0014

-32% 0.0006

Placebo-Adjusted △ p-value

≥ 32 c/h 50% Trial Population

*

*

*

*

Dose (BID)

Key learning that baseline cough frequency is an important indicator of potential treatment benefit

RELIEF: Well-Tolerated and Adverse Event Profile Comparable to Placebo

15

• Similar incidence of adverse events on placebo and active

• No treatment-related serious adverse events1

or discontinuations

• No clinically significant effect on vital signs, ECG and laboratory measures

• Limited incidence of potential P2X3 class-related side effects (taste side effects, hypoaesthesia)

15

Placebo

(N=61)

BLU-5937Total

(N=61)

n of subjects (%) with Adverse Events 41 (67.2%) 42 (68.9%)

Treatment Related Serious Adverse Events1 0 0

Most Common TEAEs (≥5% of subjects)

Headache 7 (11.5%) 6 (9.8%)

Back pain 6 (9.8%) 5 (8.2%)

Taste alteration 2 (3.3%) 5 (8.2%)

Diarrhea 3 (4.9%) 4 (6.6%)

URTI 3 (4.9%) 4 (6.6%)

Dizziness 2 (3.3%) 4 (6.6%)

Oropharyngeal pain 0 (0%) 3 (4.9%)

INCIDENCE OF MOST FREQUENT ADVERSE EVENTS (>5% INCIDENCE)

1One patient diagnosed with non treatment-related colorectal cancer

RELIEF: Limited Taste Disturbance Adverse Events

16

Placebo(n=61)

25mg BID(n=61)

50mg BID(n=61)

100mg BID(n=60)

200mg BID(n=58)

Total BLU-5937

(n=61)

Taste Disturbance 2 (3.3%) 3 (4.9%) 5 (8.2%) 5 (8.3%) 4 (6.9%) 5 (8.2%)

Partial Taste Loss 1 (1.6%) 2 (3.3%) 2 (3.3%) 2 (3.3%) 2 (3.4%) 2 (3.3%)

Complete Taste Loss 0 0 0 0 0 0

Total Taste AEs1 3 (4.9%) 4 (6.5%) 6 (9.8%) 6 (10.0%) 5 (8.6%) 6 (9.8%)

INCIDENCE OF TASTE DISTURBANCE ADVERSE EVENTS (SAFETY POPULATION)

• Limited taste adverse events at all doses (≤ 10%)

• No complete loss of taste at any dose

• No dropouts due to taste disturbance

• No severe taste adverse event

1One subject reported both taste disturbance and partial taste loss during the same period at all dose levels of BLU-5937 but is counted only once in the total taste AEs

17

BLU-5937: Favorable Drug Profile

Phase 2 proof of concept

Twice daily dosing with potential to achieve once-daily

Favorable drug characteristics:DDI unlikelyNo food effect identifiedNo off-target adverse effects identified

Potential efficient development path moving forward

Best in class selectivityBLU-5937

SOOTHE Phase 2b Trial Design & Expected RCC Commercial Considerations

Learnings from RELIEF Trial for Phase 2b Design

19

• Cough frequency at baseline is a key indicator of potential treatment benefit with ≥20 coughs/h demonstrating statistically significant and clinically meaningful benefit

• Further informed by patient level data between 20-32 coughs/h

25 coughs/h cutoff

selected doses to be evaluated in Phase 2b

PATIENT SELECTION

• 200 mg BID dose numerically outperformed other doses but cannot distinguish effect of dose level from duration of treatment

• Plasma concentrations achieved in RELIEF are consistent with achieving receptor occupancies in the 75-95+% range

• Within-patient dose response curves are shallow with overall effect size increasing with increasing baseline cough frequency

DOSE SELECTION

12.5mg, 50mg and 200mg BID

selected for Phase 2b population

SOOTHE Phase 2b – Trial DesignRandomized, double-blind, 4-week placebo-controlled parallel arm study with 3 active doses

ENDPOINTSPrimary: Change from baseline in 24H cough frequency using cough recorder in ≥25 coughs/h population

Secondary: Change from baseline in awake and nighttime cough frequency, Leicester Cough Questionnaire and Cough Severity Visual Analogue Scale

SITESApproximately 120 sites: ~50% US / ~50% ex-US

MAIN POPULATIONDiagnosed refractory chronic cough >1 year

Screening and baseline awake cough frequency ≥25 coughs/h using cough recorder

Run-In

Placebo (n=60)

BLU-5937 12.5 mg BID (n=60)

BLU-5937 50 mg BID (n= 60)

BLU-5937 200 mg BID (n=60)

Follow-Up

Main Population for Primary Endpoint - ≥25 coughs/hr

BLU-5937 200 mg BID (n=30)

Placebo (n=30)

Exploratory Population - 10-25 coughs/hr

Follow-UpRun-In

Screening

Screening

43Days: -14 0 2924H Coughrecordings:

-7

20

SOOTHE Phase 2b – Expected Timeline

4Q20:

FIRST PATIENT ENROLLED3Q21:

ENROLLMENT COMPLETED

MID21:

INTERIM ANALYSIS50% of patients in main population completed trial

Evaluation of doses using predefined efficacy and probability thresholds

Identification of dose(s) can initiate Phase 3 planning

4Q21:

TOP LINE DATATop line efficacy, safety and tolerability data

4Q20:

FDA MEETINGFeedback on Phase 2b design

21

Competitive Landscape and Commercial Considerations

P2X3 Competitive Landscape1

23

Company

Candidate MK-7264 BAY 1817080 S-600918 BLU-5937

Stage of Development phase 3 phase 2 phase 2 phase 2

Dosing BID BID QD BID

P2X3 vs. P2X2/3 Selectivity 3-7x2 ~20x3 ~ 250x4 ~ 1500x

1ST IN CLASS P2X3 ANTAGONIST

2ND GENERATION P2X3 ANTAGONISTS

BLU-5937 has best in class selectivity for P2X3 that may support potential favorable clinical and commercial profile if approved.

BEST IN CLASS SELECTIVITY FOR P2X3

1Limited head to head studies have been conducted; data presented is derived from company specific disclosures.2Smith J., Lancet Respir Med 2020: Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel group, phase 2b trial

3Safety and Efficacy of BAY 1817080, a P2X3 Receptor Antagonist, inPatients with Refractory Chronic Cough (RCC), Presenter Q&A – ERS 20204Niimi A, European Respiratory Journal 2019 54: RCT452

Merck MK-7264 (gefapixant) Phase 3 Trials

242McGarvey L., Two Phase 3 Randomized Clinical Trials of Gefapixant, a P2X3 Receptor Antagonist, in Refractory or Unexplained Chronic Cough (COUGH-1 and COUGH-2), ERS Abstract 2020

MK-72642 (gefapixant)COUGH-1: Phase 3 (12-wk)45mg BID

18%Placebo Adjusted Reduction in Awake Cough Frequency

25-30 c/hBaseline Awake Cough Frequency

58%Taste AEs

MK-72642 (gefapixant)COUGH-2: Phase 3 (24-wk)45mg BID

16%Placebo Adjusted Reduction in Awake Cough Frequency

24 c/hBaseline Awake Cough Frequency

69%Taste AEs

• Two Phase 3 trials in ~2000 patients completed in 2020 with top line reported at ERS in September 2020

• High dose (45mg BID) achieved statistical significance on the primary endpoint of 24h cough frequency, but low dose (15mg BID) did not

• No interaction with baseline cough frequency disclosed at ERS presentation

• Interaction between baseline cough frequency and treatment effect observed in two Phase 2 trials

Full Analysis Set

COUGH-1 & COUGH-2

Shionogi’s S-600918 Phase 2 TrialBaseline awake cough frequency in Shionogi Phase 2a trial most similar to RELIEF’s baseline awake cough frequency in ≥ 32 c/hour subgroup

1 Niimi A et al. ; Eur.Respir. J 2019 54: Suppl. 63, RCT4522 Not disclosed if arithmetic or geometric mean 25

Ishihara et al. ERS2020 PA2271: “Design of phase 2b randomisedcontrolled trial of S-600918, P2X3 receptor antagonist for refractory chronic cough”

• Interaction between baseline cough frequency and treatment effect observed in Phase 2a trial

• SHIONOGI Phase 2b Design: • Enrichment strategy with baseline cough frequency inclusion

criteria, ≥10 coughs/h (24-hours) • Patient stratification by baseline cough frequency to help

balance trial arms

S-600918 phase 2a1

150mg QD

32%Placebo Adjusted Reduction in Awake Cough Frequency

56 c/hBaseline Cough Frequency2

6.5%Taste AEs

Chronic Cough Patient Population – United States

26

0

10

20

30

40

50

60

70

80

90

100

Uncontrolled

~9M

Mild

~5MRCC <1 year

~6M

RCC >1 year

~3M

Total CC Patients

~26M Moderate

~3M

Severe

~1M

Well-controlled

~17M

Chronic cough patient segmentation1

(2020E)

% o

f dia

gnos

ed p

atie

nts

SeverityRCC duration

BLU-5937:Expected addressable patient population

US Market: ~9MDaily cough symptoms with mild disturbance to QoL Few adverse effects (e.g., depression, incontinence, sleep deprivation, etc.)

Mild

Frequent coughing causing lifestyle alteration. Adverse effects include mild depression, anxiety and sleep disruption.

Moderate

Intense coughing episodes causing significant discomfort and distress. Preventing ability to sleep, work, and/or socialize.

Severe

1 Company sponsored market research, 2020; no data available to segment patient population by cough frequency

P2X3 Class and BLU-5937: Pricing Comparables

27

Annual WAC cost of analogue drugsThousands of USD (2020)

Reflects annual cost of treatment for asthma; COPD treatment is ~$6K per patient per year; ** A range of doses are available at this price point

Asthma& COPD

CIC & IBS-C

Chronic constipation

Migraine High cholesterol

Advair Amitiza Linzess Aimovig Ajovy Praluent Repatha

Aprv

lYr

. 2000 2006 2012 2018 2018 2015 2015

Mo.

W

AC ~$320 ~$375 ~$450 ~$600 ~$600 ~$450 ~$450

$5k

$10k

~4.5K~4K ~5.5K ~7K ~6K~6K~7K

0

2nd Gen2nd Gen

• Pricing analogues

provide range of

$300-600 WAC per

month

Analysis of ClinicalTrials.gov; PriceRX

PRICING COMPARABLES

Company sponsored market research

BLU-5937 Phase 2 in Chronic Pruritus &Additional Indications

Pruritus is a clinical hallmark of atopic dermatitis and is associated with a severe impact on QoL

1 Wollenberg et al. JEADV (2020) epub ahead of print

Limitations of current AD treatments in addressing Pruritus

• Basis of all AD treatment plans• Efficacy limited over the course of the disease

Lifestyle changes/triggers avoidance

• First-line treatment• Limited efficacy on pruritus

Topical therapy (corticosteroids, calcineurin inhibitors)

• Sedating anti-histamines• Limited efficacy on pruritus

Anti-histamine therapy

Systemic therapy (Il-4/13 inhibitors, JAK inhibitors, systemic immunosuppressors) • Used in moderate-to-severe AD• Safety concerns with immunosuppressors or high

cost associated with biologic treatments

Pruritus in Atopic Dermatitis (AD)

• Estimated AD patient population around 5% of US adults2,3,4

2 Barbarot et al. Allergy (2018) 73(6) 1284-93

>50% of AD patients reported

itch as their most burdensome symptom4

3 Fuxench et al. JID (2019) 139(3) 583-90

4 Silverberg et al. Ann. All. Asth. Imm. (2018) 121(3) 340-7 5. 4 He A. et al. (2018) JAAD 79(1) 92-6

• AD pruritus commonly associated with excoriations, sleep disturbances, depression/anxiety, inclusive of various impacts due to scratching

BLU-5937 Second Indication: Chronic Pruritus Associated with Atopic Dermatitis

30

Similar mechanistic rationale between CHRONIC COUGH and CHRONIC ITCH in humans

Dose dependent reduction in scratching with BLU-5937 shown in an AD Mouse Model1

Inflamed or injured tissue releases ATPActivates P2X3 receptors hypersensitizing neuronsTriggers irritation signals

Irritation signals transmitted to brain through second order neurons

Irritation signals interpreted as an urge to cough or urge to itch

0

20

40

60

80

100

120

140

Vehicle BLU-59372mg/kg

BLU-593710mg/kg

BLU-593750mg/kg

U50,488 3gm/kg

No.

of s

pont

aneo

us sc

ratc

hes (

60 m

in.)

Number of spontaneous scratches in 60 min of day 8 Calcipotriol (MC903) treated mice pre-injected with vehicle, 2, 10, or 50 mg/kg BLU-5937, or 3 mg/kg U50,488. (n = 10 mice per group),*p < 0.0001, one-way ANOVA. Data are represented as mean ± S.E.M. U50,488: kappa opioid agonist

COUGH

ITCH

*

*

*

1 Chauret et al. 2019 J Invest. Derm. 139 (9) S232, 106

*

BLUEPRINT Phase 2: Trial DesignTrial initiated in 4Q 2020 with expected top line data in 4Q 2021

INCLUSION CRITERIA

• Subjects with mild to moderate AD (Investigator Global Assessment (vIGA-AD1) score of 2 or 3) & affected body surface area 0.5-10%

• Moderate to severe AD-related pruritus (weekly mean Worst Itch-Numeric Rating Scale (WI-NRS1) score ≥6 at baseline1

31

PRIMARY EFFICACY ENDPOINT

Day:

Placebo(n=64)

BLU-5937 200 mg BID(n=64)

N= 128 participants

29 Sites• 27 in US• 2 in Canada

0 287-day baseline 28-day treatment period

Daily WI-NRS

BLUEPRINT Phase 2 Design

• Proportion of subjects achieving at least 4-point improvement from baseline in weekly mean WI-NRS score at Week 4

• Change from baseline in weekly mean WI-NRS score at week 4

SECONDARY EFFICACY ENDPOINT

1 vIGA-AD: 0 (clear) – 4 (severe)WI-NRS: 0 (no itch) – 10 (worst itch imaginable)

Potential for Broad Applicability Across Important Markets

32

REFRACTORY CHRONIC COUGH• ~10% global prevalence for chronic cough1

• ~9M US adults with refractory chronic cough1

CHRONIC ITCH ASSOCIATED WITH ATOPIC DERMATITIS• ~17m US adults suffer from atopic dermatitis1

OTHER POTENTIAL INDICATIONS• Migraine • IBS

Inhibition of P2X3 receptors has therapeutic potential in a number of other indications

ENDOMETRIAL-RELATED PAIN• Affects ~4m women in

the United States1

• MK-7264 Ph2 completed JUN20202

• BAY1817080 Ph2 announced5

SLEEPAPNEA

OVERACTIVEBLADDER

NEUROPATHICPAIN

• Bronchoconstriction

1Adult population, Company sponsored market research2NCT03654326 [accessed 2020-0623]3Shionogi (2020). 2030 Vision and New Medium-Term Business Plan. Retrieved from Shionogi website.

• Affects ~23m in the United States1

• S-600918 Ph2 initiated3

• Affects ~33m in the United States1

• BAY 1817080 Ph2 initiated4

• Affects ~20m in the United States1

• S-600918 Ph2 initiated3

• BAY1817080 Ph2 announced6

• Interstitial cystitis• Hypertension

4ClinicalTrials.gov Identifier: NCT045455805ClinicalTrials.gov Identifier: NCT046142466ClinicalTrials.gov Identifier: NCT04641273

IP and Corporate Summary

100% Owned Intellectual Property Portfolio

34

N

N

X

N

R1R3

O

N

O R9

R2

R4R6

R5

R8R7

• All intellectual property 100% owned BY BELLUS with no future obligations owed

• U.S. and international patent estate covering BLU-5937 and related compounds

• Composition of matter patent for BLU-5937 and related P2X3 antagonists granted in the U.S., Europe, Japan, and China (expires in 2034 not including potential patent term extension)

• Methods of Use patent for the treatment of cough granted in the U.S. (expires 2038)

BLU-5937 composition of matter patent expires in 2034

Stock and Financial Information

35

78.3 basic shares84.0 fully diluted shares

Capital Structure1

Cash, cash equivalent and short-term investments position of US$111M2

Cash Position2

1 as of October 22, 2020

2 as of September 30th, 2020 and proforma to October 22, 2020 financing

Potential Catalysts & Upcoming Events

36

Key Anticipated Milestones in 2021

BLU-5937 in chronic cough:

• SOOTHE Phase 2b trial initiation (4Q20)

• 2021 respiratory/cough conferences:

• International Cough Symposium - January 21-22

• American Thoracic Society – May 14-19

• American Cough Conference – June 11-12

• European Respiratory Society – September 4-8

• SOOTHE interim analysis (mid-21)

• SOOTHE top-line data (4Q21)

BLU-5937 in chronic pruritus associated with AD

• Phase 2 design and first patient enrolled

(4Q20)

• BLUEPRINT top-line data (4Q21)

Third Party P2X3 trials

• Phase 2 trials in overactive bladder,

neuropathic pain, pain-related to

endometriosis and sleep apnea