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State of Israel Ministry of Industry, Trade & Labor
Investment Promotion Center
Invest In IsraelWhere Breakthroughs Happen
Creating Synergies in Life SciencesCreating Synergies in Life Sciences
Main Economic IndicatorsMain Economic Indicators
2008200720062005Criteria
199.4164.1144.0133.2GDP (current prices in $B)
4.0%5.4%5.2%5.1%GDP Real Growth Rate (%)
$28,473$27,395$24,271$23,206
GDP per Capita
(PPP adjusted)
GDP per Capita Growth Rate
Sources: Bank of Israel, Ministry of Finance, International Monetary Fund
2.1%3.5%3.3%3.3%GDP per Capita Growth Rate
(%, Current prices)
80.4
(40.3%)
71.2
(43.4%)
62.6
(43.5%)
57.2
(43.0%)
Exports (Goods & Services in $B)
(As Percentage of GDP)
84.1
(42.2%)
74.0
(45.1%)
62.2
(43.2%)
57.5
(43.2%)
Imports (Goods & Services in $B)
(As Percentage of GDP)
6.1%7.3%8.4%9.0%Unemployment Rate (%)
2
Highlights
� Highest civilian R&D expenditure/GDP (4.7% of GDP)
� Largest number of scientists per capita in the world and dedicates one third of its research budget to the Life Sciences.
� First in the world for Medical Device Patents per Capita, Fourth for Bio-Pharma Patents.
3
Fourth for Bio-Pharma Patents.
� Fourth in investments in Biotechnology/GDP
� Rated 3rd worldwide in Medical Device area
� More than 18 drugs in advanced clinical trials (3rd in Europe)
Israel’s Competitive Edge – IMD World Report 2008
Country Rank ����
BUSINESS EXPENDITURE ON R&D
TOTAL EXPENDITURE ON R&DAS A PRECENTAGE OF GDP
AVAILABILITY OF QUALIFIED ENGINEERS
KNOWLEDGE TRANSFER BETWEEN
2nd
Sweden
Sweden
Israel
3rd
Japan
Finland
Chile
4th
Korea
Japan
Taiwan
1st
Israel
Israel
Singapore
U.S.AKNOWLEDGE TRANSFER BETWEEN INDUSTRY AND ACADEMIA
VENTURE CAPITAL AVAILABILITY
Israel
Hong Kong
Switzerland
Israel
Source: IMD World Competitiveness Yearbook - 2008
Singapore
U.S.A
INFORMATION TECHNOLOGY SKILLS Singapore Israel
Singapore
Sweden U.S.A
U.S.A
Israel Ranks 20
RESILIENCE OF THE ECONOMY Australia Denmark Switzerland Israel
4
Acquisitions of Israeli Life Science CompaniesDateSectorCompanyAmount($M)Acquirer
2009Medical DevicesVentor325Medtronic
2009Medical TechnologyOptonol Ltd.180Alcon Inc.
2009Laboratory Information
Management
Starlims
Technologies
123Abbott
Laboratories
2008BiotechnologyOmrix447Johnson &
Johnson
2008Medical DevicesMediGuide300St. Jude
2008DentalAlphaBioTec95Nobel BioCare
2007PharmaceuticalsTaro454Sun Pharma
2007Medical DevicesRamon80Boston Scientific
2006Medical DevicesDisc-O-Tech220Kyphon
5
Foreign Companies Invested in Israel - Some Examples
US
• Perrigo
• GE Healthcare
• Johnson & Johnson
• Dentsply
• Stryker
• Boston Scientific
• Microsoft
• AOL Time Warner
Europe
• Philips Medical
• Ferring
• Merck-Serrono
• British Telecom
• SAP
• Alcatel
• Siemens
• Cable & Wireless
Asia
• Sun Pharmaceutical
• Scigen
• Sony
• Toyo Ink
• Fuji
• Honda
• Sumitomo Trading
• Nomura
• Intel
• IBM
• Cisco Systems
• Lucent
• 3Com
• Hewlett Packard
• Motorola
• Sun Microsystems
• Deutsche Telekom
• Telecom Italia
• Generali
• Nestle
• L’Oreal
• Danone
• Unilever
• Vilmorin
• Veolia
• Samsung Electronics
• Daewoo
• LG Group
• Hyundai
• Acer Computers
• Macronix
• Winbond
• Hutchison Telecomm
• Jain Irrigation
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Israel Life Sciences Cluster
SuccessfulLife science Companies
Availability ofHuman Capital
ExistingTechnology
Infrastructure
University Medical, Science
Students and Postgraduates
DefenseTechnology
Spillover
CorporateR&D
LeadingAcademic
Institutions & Research
Seasoned VC Community
Immigration
7
Capital
Global Life Science
Firms Veterans
Technological Incubators
Strong Government
Support
Innovative &Entrepreneurial
Culture
Hospitals and Medical Centers
Israel’s Life Sciences IndustryBlockbuster Launched Products
ProductProductProductProduct IndicationIndicationIndicationIndication Company Company Company Company LicenseeLicenseeLicenseeLicensee
RevenuesRevenuesRevenuesRevenues2008200820082008
Academic Academic Academic Academic InstituteInstituteInstituteInstitute
InventorInventorInventorInventor
CopaxoneCopaxoneCopaxoneCopaxone((((glatiramer acetate)glatiramer acetate)glatiramer acetate)glatiramer acetate)
Multiple Multiple Multiple Multiple SclerosisSclerosisSclerosisSclerosis
TevaTevaTevaTeva $$$$M M M M 2222,,,,260260260260 Weizmann Weizmann Weizmann Weizmann InstituteInstituteInstituteInstitute
Michael SelaMichael SelaMichael SelaMichael Sela
RebifRebifRebifRebif((((interferon betainterferon betainterferon betainterferon beta----1111a) a) a) a)
Multiple Multiple Multiple Multiple SclerosisSclerosisSclerosisSclerosis
MerckMerckMerckMerck----SeronoSeronoSeronoSerono €€€€M M M M 1111,,,,331331331331 Weizmann Weizmann Weizmann Weizmann InstituteInstituteInstituteInstitute
Michel RevelMichel RevelMichel RevelMichel Revel
ExelonExelonExelonExelon((((rivastigmine tartrate)rivastigmine tartrate)rivastigmine tartrate)rivastigmine tartrate)
Alzheimer’sAlzheimer’sAlzheimer’sAlzheimer’s NovartisNovartisNovartisNovartis $$$$M M M M 815815815815 Hebrew Hebrew Hebrew Hebrew UniversityUniversityUniversityUniversity
Marta RosinMarta RosinMarta RosinMarta Rosin
Doxil / CaelyxDoxil / CaelyxDoxil / CaelyxDoxil / Caelyx CancerCancerCancerCancer J&JJ&JJ&JJ&J Hebrew Hebrew Hebrew Hebrew UniversityUniversityUniversityUniversity
Alberto Alberto Alberto Alberto GabizonGabizonGabizonGabizon
Israel’s Life Sciences Industry
Blockbuster Launched Products
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((((Doxorubicin liposome)Doxorubicin liposome)Doxorubicin liposome)Doxorubicin liposome) ScheringScheringScheringSchering---- PloughPloughPloughPlough $$$$M M M M 430430430430 UniversityUniversityUniversityUniversityHadassah Hadassah Hadassah Hadassah HospitalHospitalHospitalHospital
GabizonGabizonGabizonGabizon
AzilectAzilectAzilectAzilect((((rasagiline )rasagiline )rasagiline )rasagiline )
ParkinsonParkinsonParkinsonParkinson TevaTevaTevaTeva $$$$M M M M 175175175175Launched July Launched July Launched July Launched July
2006200620062006
TechnionTechnionTechnionTechnion Moussa Moussa Moussa Moussa YoudimYoudimYoudimYoudim
ErbituxErbituxErbituxErbitux CancerCancerCancerCancer MerckMerckMerckMerck----SeronoSeronoSeronoSeronoBristolBristolBristolBristol----Meyers Meyers Meyers Meyers
Squibb Squibb Squibb Squibb
€€€€M M M M 565 565 565 565 Launched Launched Launched Launched 07070707----2008200820082008
M$M$M$M$ 749749749749
Weizmann Weizmann Weizmann Weizmann InstituteInstituteInstituteInstitute
Michael Michael Michael Michael SelaSelaSelaSela
Israel’s Life Sciences Industry – Sectors
Medical Device 56%Biotechnology 20%
Pharmaceutical 12%
Agro Biotech 3%
Medical IT 5% Services 2% Other, 2%
Companies’ Developmental Stage
9Source: ILSI Database – 2009
Revenue 39%
Pre-Clinical 12%
Clinical 18%
Seed 26%
Other 5%
Companies’ Developmental Stage
Main Medical Fields
0
10
20
30
40
50
60
70
80
90
0
Source: ILSI Database – 2009 10
Medical Device Patents per Million Capita 2007
8
10
12
14
16
18
Source: www.uspto.gov, Analysis: ILSI ©
0
2
4
6
8
United States
Japan Germany United Kingdom
France Canada Israel South Korea
Taiwan
11
BioPharma Patents per Million Capita - 2007
Source: www.uspto.gov, Analysis: ILSI © 12
Major Therapeutic Areas:
� CNS – Four Blockbuster drugs in market (Copaxone,
Rebif, Exelon, Azilect)
5 Additional drugs in clinical stages
� Regenerative medicine & Cell Therapy (20 active
companies, 4 in clinical trials)
� Cancer - Cell Therapy, Monoclonal Antibodies, Small
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� Cancer - Cell Therapy, Monoclonal Antibodies, Small
Molecules, Image Guided Technologies
� Inflammation & Autoimmunity
� Cardiovascular
� Infectious diseases, Vaccines
Israeli Biotechnology Innovations
� Can-Fite has developed a platform technology that targets the A3 Adenosine Receptor for treatment of cancer and autoimmune inflammatory diseases.
� Gamida Cell is developing unique stem cells therapeutics, based on its proprietary stem/progenitor cells expansion technologies.
� Rosetta Genomics is a leader in the development of microRNA-based diagnostics and therapeutics
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� BrainStorm Cell Therapeutics uses autologous bone marrow derived adult stem cells to combat Parkinson Disease.
� Cell Cure employs human embryonic stem cell technology for Parkinson.
� And …Biocancell(Gene therapy), BiondVax (Intra nasal vaccines for several flu strains), Compugen (threapeutic &diagnostic drug discovery)
Israeli Medical Devices Breakthroughs
Insightec - Image Guided HIFUS (High Intensity Focused Ultrasound)
Given Imaging - 1st ingestible video camera used to view the small intestine and diagnose disorders
Medinol - pioneered the development of closed cell
15
GE Healthcare in Israel manufactured the world’s first miniaturized portable cardiac ultrasound system
Medinol - pioneered the development of closed cell stent design and many additional innovations to the field of heart catheterization.
Israeli Medical Devices Breakthroughs (II)
The Philips Brilliance CT scanner, developed in Israel takes a comprehensive picture of a patient in seconds instead of minutes.
Galil Medical - Cryotherapy for minimally invasive
targeted ablation
Insightec - MRI guided non-invasive surgical procedure
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3D Endoscope • 3D Dental Mapping • Fixed non-cooled Magnet Open MRI •
Simulators for Medical Procedures • Labor Monitoring • NiTiNOL Tooling •
Intravascular miniaturized MRI imager • Spectral Imaging Device •
Various Stents • Revolutionary Rectoscope • Implantable Insulin Generator •
And many more…
Stem Cells
• Israel is one of the world centers for stem cells
research and technology development.
• The Jewish religion does not hinder stem cell research
– unlike in other cultures - a significant plus.
• Israeli scientists are the most prolific authors on a per capita basis of published articles related to stem cell research.
• There are about 20 companies actively engaged in this new industry.
17
Summary
� Israel is a center of innovation and technological
excellence
� Israel is a source for profit driving innovation in the fields
of Medical Technology and Bio-Pharma
� Foreign companies can conduct cutting edge research in Israel cost effectively .
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� Favourable government support programs: Investment grants, Tax benefits and R&D grants
� Invest in Israel’s main purpose is to assist investors
establish a presence in Israel. Please contact us.
State of Israel Ministry of Industry, Trade & Labor
Investment Promotion Center
5 Bank Israel St., Kiryat Ben-Gurion Jerusalem, Israel
www.investinisrael.gov.il [email protected]
Tel: +972-2-6662607 Fax:+972-2-6662983