“ “ Its all about the Its all about the timing… timing… Echo cardiogram enhancement Echo cardiogram enhancement through ECG/EKG triggering through ECG/EKG triggering ” ” A presentation by Prof. David A. A presentation by Prof. David A. Rivkin, PhD Rivkin, PhD President & Chief Scientist, GCPI President & Chief Scientist, GCPI Adjunct Professor, Drexel Adjunct Professor, Drexel University University IEEE Senior Member, EMBS Distinguished Lecturer IEEE Senior Member, EMBS Distinguished Lecturer Chairman, IEEE SCV Instrumentation and Measurement Chairman, IEEE SCV Instrumentation and Measurement Society Society Chairman, IEEE Instrumentation and Measurement Chairman, IEEE Instrumentation and Measurement Society Technical Committee 34 “Nanotechnology In Society Technical Committee 34 “Nanotechnology In Instrumentation and Measurement” Instrumentation and Measurement” IEEE Nanotech Council Executive Member IEEE Nanotech Council Executive Member AdvaMed Medical Device Industry Council Advisor AdvaMed Medical Device Industry Council Advisor ISO TC-229 “Nanotechnology Standards” IEEE Liaison ISO TC-229 “Nanotechnology Standards” IEEE Liaison Chairman, STI Emerging Technologies SIG Chairman, STI Emerging Technologies SIG Fellow, Society for Industrial & Applied Mathematics Fellow, Society for Industrial & Applied Mathematics
Transcript
““Its all about the timing…Its all about the timing…Echo cardiogram enhancement Echo cardiogram enhancement
through ECG/EKG triggeringthrough ECG/EKG triggering””A presentation by Prof. David A. Rivkin, A presentation by Prof. David A. Rivkin,
Adjunct Professor, Drexel UniversityAdjunct Professor, Drexel University
IEEE Senior Member, EMBS Distinguished LecturerIEEE Senior Member, EMBS Distinguished LecturerChairman, IEEE SCV Instrumentation and Measurement Chairman, IEEE SCV Instrumentation and Measurement SocietySocietyChairman, IEEE Instrumentation and Measurement Society Chairman, IEEE Instrumentation and Measurement Society Technical Committee 34 “Nanotechnology In Instrumentation Technical Committee 34 “Nanotechnology In Instrumentation and Measurement”and Measurement”IEEE Nanotech Council Executive MemberIEEE Nanotech Council Executive MemberAdvaMed Medical Device Industry Council AdvisorAdvaMed Medical Device Industry Council AdvisorISO TC-229 “Nanotechnology Standards” IEEE LiaisonISO TC-229 “Nanotechnology Standards” IEEE LiaisonChairman, STI Emerging Technologies SIGChairman, STI Emerging Technologies SIGFellow, Society for Industrial & Applied MathematicsFellow, Society for Industrial & Applied Mathematics
Timing of the PresentationTiming of the Presentation
The Problem – Blurry Pictures…The Problem – Blurry Pictures… Previous Solutions – Big Computers…Previous Solutions – Big Computers… New Solution – Embedded Monitor/TriggerNew Solution – Embedded Monitor/Trigger Unified Solution – Best Timely ResultsUnified Solution – Best Timely Results Overview of Design – How it worksOverview of Design – How it works Overview of Management – Why its on timeOverview of Management – Why its on time Conclusion – Its about timeConclusion – Its about time
The Problem – Blurry The Problem – Blurry PicturesPictures
X-RayX-Ray Echo Echo
CardiogramCardiogram CTCT 3D Ultrasound3D Ultrasound PETPET Electrical Electrical
Use ECG Data to Use ECG Data to Trigger ImagerTrigger Imager
Signal Processing to Signal Processing to Determine Trigger Determine Trigger PointPoint
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
Electro Cardiogram Electro Cardiogram (ECG/EKG) Data:(ECG/EKG) Data: Well knownWell known Simple to collectSimple to collect
Up to 12 Point Data Up to 12 Point Data CollectionCollection
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
Peaks can act as Peaks can act as simple triggerssimple triggers
E.g. Trigger on E.g. Trigger on Ventricular Ventricular Contraction Contraction
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
ECG Signals ECG Signals Indicate more Indicate more complex activities complex activities of the heart than of the heart than just Ventricular just Ventricular ContractionContraction
Any Phase of the Any Phase of the Cardiac Rhythm Cardiac Rhythm can be determinedcan be determined
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
ECG with Signal ECG with Signal Processing can Trigger Processing can Trigger at any point, on any at any point, on any peak or with delayspeak or with delays
Some imagers (such Some imagers (such as ultrasound) have as ultrasound) have inherent delay inherent delay allowing for triggering allowing for triggering to be after the image to be after the image is already collectedis already collected
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
ECG based ECG based software control of software control of triggeringtriggering
Advanced Advanced algorithms can be algorithms can be used to trigger only used to trigger only upon abnormalities upon abnormalities in ECG datain ECG data
New Solution – New Solution – Embedded Monitor/TriggerEmbedded Monitor/Trigger
Proper triggering can Proper triggering can enhance location of enhance location of abnormalities in abnormalities in heart dimensions or heart dimensions or functionfunction
E.g. Abnormal Blood E.g. Abnormal Blood Flow indicating hole Flow indicating hole in heart wall in heart wall otherwise not otherwise not detecteddetected
Combining Combining Advanced Advanced Triggering with Triggering with Advanced CT Advanced CT Algorithms results Algorithms results in the best imagesin the best images
Overview of Design – How it Overview of Design – How it worksworks
Standard 3M RedDot adhesive electrodesStandard 3M RedDot adhesive electrodes Standard connectors and cablingStandard connectors and cabling
Overview of Design – How it Overview of Design – How it worksworks
Virtex-4 LX25 FPGA Virtex-4 LX25 FPGA 24,192 Logic Cells 24,192 Logic Cells 128 MB RAM 128 MB RAM 64 MB Flash ROM 64 MB Flash ROM JTAG Hardware Debugging JTAG Hardware Debugging 48 Billion Multiply and 48 Billion Multiply and
Accumulates / Second Accumulates / Second
Mechanical SpecificationMechanical Specification Temperature Range: -40° C to Temperature Range: -40° C to
+85° C +85° C
Developed on Standard Developed on Standard Virtex4 Prototype BoardVirtex4 Prototype Board
Overview of Design – How it Overview of Design – How it worksworks
Overkill for the Overkill for the applicationapplication
Would have taken Would have taken longer to developlonger to develop
Overview of Design – How it Overview of Design – How it worksworks
Developed Entirely in Developed Entirely in SystemCSystemC
Prototyped on Dual Prototyped on Dual Processor AMD64 Processor AMD64 desktopdesktop
SystemC to VHDL by SystemC to VHDL by SystemCrafter SCSystemCrafter SC
Xilinx IDE WebPackXilinx IDE WebPack GBit Ethernet, USB or GBit Ethernet, USB or
Serial Update of Serial Update of EEPROMEEPROM
Overview of Design – How it Overview of Design – How it worksworks
Isolation/Instrumentation Isolation/Instrumentation Amplifiers and Isolation Amplifiers and Isolation Power SupplyPower Supply
TTL, CMOS, RS-232 and TTL, CMOS, RS-232 and USB Trigger Lines USB Trigger Lines Provided for different Provided for different manufacturers manufacturers interfacing needsinterfacing needs
Overview of Management – Overview of Management – Why its on time…and under Why its on time…and under
budgetbudget 5 Months from conception to First Articles 5 Months from conception to First Articles
generated by CEM, scheduled for 6 generated by CEM, scheduled for 6 monthsmonths
Under Budget by 4%Under Budget by 4% Entering Clinical Trials currentlyEntering Clinical Trials currently Compliant with ISO13485:2005 and Compliant with ISO13485:2005 and
21CFR82021CFR820 ““Avoid Verbal Orders, Say It In Writing”Avoid Verbal Orders, Say It In Writing”
Overview of Management – Overview of Management – Why its on time…and under Why its on time…and under
budgetbudget Program Management Program Management
Overview of Management – Overview of Management – Why its on time…and under Why its on time…and under
budgetbudget GPES – Global GPES – Global
Performance Performance Evaluation SystemEvaluation System
Real-Time Program Real-Time Program & Project Status& Project Status
Developed by NASA Developed by NASA at Johnson Space at Johnson Space CenterCenter
Open Source ASP on Open Source ASP on MS SQLServerMS SQLServer
Overview of Management – Overview of Management – Why its on time…and under Why its on time…and under
budgetbudget GPES Source Code GPES Source Code
Modified to Use Modified to Use Stochastic MethodsStochastic Methods
(o) = Most optimistic (o) = Most optimistic durationduration - - everything everything will go according to will go according to plan with a minimal plan with a minimal amount of difficulties. amount of difficulties.
(p) = Most pessimistic (p) = Most pessimistic duration - everything duration - everything will not go according will not go according to plan and maximum to plan and maximum potential difficulties potential difficulties will develop.will develop.
(m) = Most likely (m) = Most likely duration - will most duration - will most often occur should this often occur should this effort be repeated effort be repeated over and over again over and over again
= the sum of all critical path expected = the sum of all critical path expected times.times.
= the sum of all critical path = the sum of all critical path variances.variances.
= the number of standard deviations = the number of standard deviations of a normal distribution (the of a normal distribution (the standard normal deviate)standard normal deviate)
D T Ze 2
Te2
ZTE
o m p
Variancep o
4
6
62
2
Values for Z can be taken from “Project Management, A Managerial Approach,” Jack R. Meredith and Samuel J. Mantel, Jr., John Wiley & Sons, NY, 1995
Overview of Management – Overview of Management – Why its on time…and under Why its on time…and under
Conclusion – Its about timeConclusion – Its about time
New and exciting technologies are New and exciting technologies are changing the way products are changing the way products are developed.developed.
SystemC offers new ways to design, SystemC offers new ways to design, prototype and develop unified prototype and develop unified Software/Hardware products using Software/Hardware products using non-traditional computing methodsnon-traditional computing methods
Conclusion – Its about time!Conclusion – Its about time!
Any Questions?Any Questions?
Thank you for your Thank you for your patience!patience!
By Prof. David A. Rivkin, By Prof. David A. Rivkin, PhDPhD
