Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen
Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
by Laura Bonifaz, David Bonnyay, Karsten Mahnke, Miguel Rivera, Michel C. Nussenzweig, and Ralph M. Steinman
JEMVolume 196(12):1627-1638
December 16, 2002
© 2002 Rockefeller University Press
Conjugation and delivery of OVA via monoclonal antibodies.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
Targeting of αDEC-205:OVA to CD11c+ lymph node DCs in vitro.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
Targeting of αDEC-205:OVA to lymph node CD11c+ DCs in vivo.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
Maturation of DCs in vivo by agonistic αCD40 but not by αDEC-205:OVA.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
Contrasting responses of OT-I T cells to αDEC-205:OVA in the presence or absence of αCD40-induced DC maturation.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
Deletion of OT-I T cells in response to αDEC-205:OVA in steady state.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
αDEC-205:OVA induces peripheral tolerance to OVA in the steady state.
Bonifaz L et al. JEM 2002;196:1627-1638
© 2002 Rockefeller University Press
