1 CURRICULUM VITAE James Samuel Malter, M.D. Date Prepared: Dec. 1, 2018 Office and Mailing Address: 5323 Harry Hines Blvd. UT Southwestern Medical Center Dallas, Texas 75390-9072 214-648-4025 (secretary), 214-648-1117 (lab), 214-648-4088 (office), 214-648-1102 (fax) E-Mail: [email protected]Home Address: 1204 North Windomere Ave Dallas, Texas 75208 214-943-5902 Date of Birth: May 18, 1956 Place of Birth: Toolele, Utah Marital Status: Married Education: 1983, M.D., Washington University School of Medicine, St. Louis, MO 1979, A.B., cum laude, Highest Distinction, Biochemistry, Dartmouth College, Hanover, NH 1974, cum laude, Milton Academy, Milton, Mass. Postgraduate Training: 1987-88 Chief Resident, Laboratory Medicine (CP) Hospital of the University of Pennsylvania, Philadelphia, PA 1985-88 Research Associate, Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA. 1983-88 Laboratory Medicine (CP) Resident, Department of Pathology & Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.
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CURRICULUM VITAE
James Samuel Malter, M.D. Date Prepared: Dec. 1, 2018 Office and Mailing Address: 5323 Harry Hines Blvd. UT Southwestern Medical Center Dallas, Texas 75390-9072 214-648-4025 (secretary), 214-648-1117 (lab), 214-648-4088 (office), 214-648-1102 (fax) E-Mail: [email protected] Home Address: 1204 North Windomere Ave Dallas, Texas 75208 214-943-5902 Date of Birth: May 18, 1956 Place of Birth: Toolele, Utah Marital Status: Married Education:
1983, M.D., Washington University School of Medicine, St. Louis, MO 1979, A.B., cum laude, Highest Distinction, Biochemistry, Dartmouth College, Hanover, NH 1974, cum laude, Milton Academy, Milton, Mass.
Postgraduate Training:
1987-88 Chief Resident, Laboratory Medicine (CP) Hospital of the University of Pennsylvania, Philadelphia, PA
1985-88 Research Associate, Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
1983-88 Laboratory Medicine (CP) Resident, Department of Pathology & Laboratory
Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.
1998 Elected Member, American Society for Clinical Investigation (ASCI) 1993 Nominee - Romnes Fellow, University of Wisconsin, Madison, WI 1987 Outstanding Young Investigator, Academy of Clinical Laboratory
Physicians & Scientists 1986-88 NIH National Research Service Award 1985-86 Departmental Endowment Award, Department of Pathology & Laboratory
Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 1978-79 Rufus Choate Scholar, Biochemistry - Dartmouth College
Academic Appointments:
2011 - Professor (tenured) and Chair; Senator Betty and Dr. Andy Andujar Distinguished Chairman in Pathology, University of Texas Southwestern Medical School, Dallas, TX
2004-11 Associate Director for Biological Sciences, Waisman Center for Developmental
Disabilities, University of Wisconsin, Madison 2003-11 Cell and Molecular Neuroscience Core Leader, Intellectual and Developmental
Disabilities Research Center (IDDRC), Waisman Center, University of Wisconsin, Madison
2002-11 Investigator, Waisman Center for Developmental Disabilities, University of
Wisconsin, Madison 1997-2011 Professor (tenured), Department of Pathology and Laboratory Medicine, University
of Wisconsin School of Medicine and Public Health, Madison, WI 1993-95 Interim Chair, Department of Pathology and Lab Medicine, University of
Wisconsin School of Medicine and Public Health
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1992-97 Associate Professor (tenured), Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health
1991-92 Assistant Professor (tenure track), Department of Pathology and Laboratory
Medicine, University of Wisconsin School of Medicine and Public Health 1991-2011 Investigator, University of Wisconsin Comprehensive Cancer Center 1990-91 Assistant Professor (secondary appointment), Department of Pharmacology, Tulane
University School of Medicine, New Orleans, LA 1988-91 Assistant Professor (primary appointment, tenure track), Department of Pathology,
Tulane University School of Medicine, New Orleans, LA 1987-88 Instructor, Department of Pathology & Laboratory Medicine, University of
Pennsylvania School of Medicine, Philadelphia, PA 1983-87 Assistant Instructor, Department of Pathology & Laboratory Medicine, of
Pennsylvania, School of Medicine, Phil, PA
Clinical Service Appointments:
2017- Medical Director, Next-Generation Sequencing Laboratory, Department of Pathology, UT Southwestern Medical Center, Dallas, TX
2002-2008 Co-Director and Medical Director, Molecular Diagnostics Laboratory, UW Hospital
1991-2011 Director, Transfusion Service, University of Wisconsin Hospital and Clinic,
Madison, WI (included Therapeutic Apheresis, Blood Bank and Infusion Center) 1989-91 Director of Blood Center, Tulane University Medical Center, NO, LA (included
Donor Center, Therapeutic and Donor Apheresis and Transfusion Service) 1988-91 Director, Division of Experimental and Molecular Pathology, Department of
Pathology, Tulane University Medical Center, NO, LA. 1988-91 Medical Director, Flow Cytometry Laboratory, Department of Pathology, Tulane
University Medical Center, NO, LA.
University Committees and Service: Tulane University School of Medicine (1988-1991): Institutional Bio-safety Committee Quality Care Committee, Tulane Medical Center Tulane Medical Center Laboratory Consortium Executive Committee of the Laboratory Consortium
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Cell and Molecular Biology Graduate Program Steering Committee Cell and Molecular Biology Task Force Center for Bioenvironmental Research Task Force Volunteer Grant Committee Charity Hospital of New Orleans Transfusion Review Committee Medical Center Research Instrumentation Committee Basic Research Science Grant Committee University of Wisconsin, Madison (1991-2011): Department of Pathology/Lab Medicine:
1992-96 University Physicians Retirement Fund Committee 1991-2008 Director, Transfusion Medicine Fellowship Program 1992-95 Seminar Selection Committee 1992-2008 Residency Selection and Review Committee 1992-94 Tenure Review Committee 1992-95 University Physicians in Pathology Executive Committee 1992-2011 Department Executive Committee 1992 Chair-Search Committee, Hematopathologist 1992-93 Chair-Search Committee, Neuropathologist 1993-03, 08-11 Graduate Education Committee (’93-), Director (‘96-‘03), Co-Director
(‘08-‘11) 1995-03 Chair-Compensation Committee 1996-01 Member-Faculty Mentoring Committee, Mani Mahadevan MD 1997 Chair-Laboratory Information System Physician Advisory Committee 1997 Utilization Review Steering Committee 1998-2011 Chair-Transfusion Service QA Committee 1997-02 Chair-Faculty Mentoring Committee, Andreas Friedl MD 2000-01 Chair-Search Committee, Hematopathologist 2001-07 Chair-Faculty Mentoring Committee, Michael Fritsch MD, Ph.D. 2001 Chair-5 year post tenure review, Alan Rapraeger, Ph.D. 2002 Chair-5 year post tenure review, Terry Oberley MD, Ph.D. 2003 Chair-5 year post tenure review, David Watkins, Ph.D. 2002-6 Member, Research Committee 2003-2011 Chair-Faculty Mentoring Committee, Luis Fernandez MD,
Dept of Surgery 2006-07 Member, Finance Committee 2007 Chair-5 year post tenure review, Alan Rapraeger, Ph.D. 2007 Chair - 5 year post tenure review, Dan Greenspan, Ph.D. 2007-11 Chair, Faculty Mentoring Committee, Ken Young, MD, PhD,
Dept of Pathology 2009 Chair - 5 year post tenure review, Zsuzsana Fabry, MD, Ph.D.
University of Wisconsin Medical Foundation (UW Physicians Multispecialty Group Practice)
1993-95 Governance and Finance Subcommittee 1993-94 Board of Directors, University Health Care Inc. 1993-94 Board of Directors, Health Professionals Inc. 1993-94 Board of Directors, Associated University Physicians 1993-95 Board of Directors, Clinical Practice Plan 1994 Search Committee for COO of Medical Foundation 1994-5 Chair, Breast Cancer Operations Committee 1995 Chair, Retirement Plan Task Force 1995 Transition Team, UW Medical Foundation 1995-2005 Council of Faculty 1995-98 Alternate Member, Board of Directors 1995-2011 Chair, Retirement Committee 1996-99 Chair, Long Range Planning Committee 1996-01 Member, Committee Chairs Caucus 2001 Revenue Enhancement Team 2001 Funds Flow and Integration Team 2000-02 Member, Finance Committee 2002-11 Member, Fee Committee 2006-11 Member, Investment Committee
University of Wisconsin Hospital and Clinic:
1991-2011 Blood Product Utilization Review Committee (Chair, ‘92-2011) 1991-2005 Quality Evaluation and Review Committee 1992-2011 Operating Room Committee-UWHC 1992-95 Physicians Advisory Committee-Hospital Information System 1993-95 Clinical Standards Subcommittee, UW Hospital and Clinics 1993-95 Medical Board 1994 Member, U Care HMO Scientific Advisory Group 1994-5, 2000-1 Chair, Albumin Use QA Committee 1994 Chair, Informed Consent Committee, UWHC 1997 Co-Chair, Long Range Planning Committee, Network Development 1997 Member, Strategic Planning Steering Committee 1997-8 Member, Cancer Treatment Clinic Planning Committee 2000-1 Chair-Blood Procurement Task Force 2001-4 Member-Performance Improvement Team – Critical Values 2006-11 Patient Satisfaction and Quality Committee 2009-11 IVIG Task Force
University of Wisconsin School of Medicine and Public Health
1993-95 Dean's Seminar Committee 1993-95 Faculty Development Committee 1993-94 Health Sciences Planning Committee-Core Facilities 1993-95 Clinical Chairs Caucus 1993-95 Basic Science Chairs Caucus 1994-5 Educational Policy Oversight Committee 1994-5 Human Genetics Development Committee
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1994-6 Medical School Clinical/Basic Science Grant Review Committee 1995 LCME Finance Task Force 1994-5 Faculty Roles and Rewards Committee 1995-2011 Committee of Peers, UW Foundation Fund Raising (‘95-2011), Chair (‘96-‘97) 1999-00 Academic Compensation Subcommittee 2008-10 CTSA Internal Grant Review Committee 2010-11 Medical Scientist Training Program Steering Committee
University of Wisconsin Comprehensive Cancer Center
Assessment 2011- Member, Professional Liability Committee 2011- Member, Dean’s Advisory Committee 2011- Member, Faculty Advisory Council 2011- Member, VA Advisory Council 2011-12 Member, Administrative and Business Affairs Subcommittee 2011-12 Member, Clinical Planning Subcommittee 2011- Member, Medical Service Research and Development Plan Board (MSRDP)
Finance Committee 2011- Member, VA Dean’s Committee 2012-13 Member, Surgery Chair Search Committee 2012-4 Member, Executive Committee of the Clinical Chairs 2013- Member, IT Strategic Planning Committee 2013-14 Member, Institutional COI Committee 2013- Member, Clinical Planning Committee 2011- Member, Planning Committee, Administrative and Academic Operations 2014- Member, UTSW Research Biospecimen Committee 2014-5 Member, Alzheimer’s Disease Center Director Search Committee 2015 Member, Compliance, Ethics and Professional Affairs Committee 2014- Member, Conflict of Interest Committee 2016 Member, Department of Immunology Chair Search Committee 2017-8 Member, Department of Clinical Sciences Chair Search Committee
American Red Cross, Badger-Hawkeye Region, Madison, WI:
1992-98 Member, Blood Services Board of Directors 1992-2011 Member, Medical Advisory Committee 1997-98 Member, CEO Search Committee, Badger/Hawkeye Region
LifeSource Blood Services, Chicago, IL 2002-04 Member, Board of Directors 2002-04 Member, Quality Committee
Other 1995-2011 Madison Rotary Club 2014-7 At Large Delegate, Board of Directors, Texas Society of Pathology 2015-7 Chair, Resident and Fellows Poster Judging, Texas Society of Pathologists 2017-8 Secretary, Board of Directors, Texas Society of Pathology 2019-20 Vice President, Texas Society of Pathology 2020-21 President-elect, Texas Society of Pathology
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Regular Journal Reviewer: Hepatology Journal of Molecular Biology Nucleic Acids Research Blood Infection and Immunity J Cell Science Brain Research American J of Hematology J of Immunology J of Neuropathology and Experimental Neurology Biochemia and Biophysics Acta J Cellular Physiology J Biological Chemistry Developmental Genetics European J Biochemistry J Neurochemistry EMBO J Molecular and Cell Biology J Experimental Medicine Genes and Development J Cell Biology Annals of Surgery J Leukocyte Biol Nature Immunology Nature Communications Exp Lung Research Science Science Signaling Cell Death and Differentiation Current Alzheimer’s Research National Review Service:
1989 NIH, Biochemistry, Ad Hoc Reviewer 1989-91 United States Department of Agriculture, External Reviewer 1992-98 NSF (U.S.), External Reviewer, Molecular Biochemistry 1992-98 VA Merit Review-Hematology, External Reviewer 1993-98 University Hospitals Consortium, 1993-94 Guthrie Research Institute, External Reviewer, 1997 NIH, Physiologic Biochemistry, Ad Hoc Reviewer, 1997-02 NIH Molecular, Developmental, Cellular Neuroscience (MDCN-2), Permanent Member, 1998-99 United States Department of Agriculture, Reviewer 1999-04 VA Merit Review-Neurobiology D, Permanent Member 2002 NIH/NINDS, NSD-C, Ad Hoc Reviewer, 2004 NIH/NINDS, ZNS1 SRB-M, Ad Hoc Reviewer
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2004, ‘05 NIH ZRG1 MDCN-F, Ad Hoc Reviewer 2006-08 NIH ZRG1 NOMD-A, Founding Chair, Permanent Member, 2009 NIH ZRG1 MDCN-F, ARRA Challenge Grant Review, Ad Hoc Reviewer, 2009 NIH ZRG1 MDCN-A (52), ARRA R15 Grant Review, Ad Hoc Reviewer 2010- NIH College of Reviewers, Center for Scientific Review 2010 NIH ZRG1 MDCN-N (91) S, Chair 2011 NIH ZRG1 MDCN-P (02) M, Chair 2012 NIH ZRG1 MDCN-E (02) M, Chair 2015 NIH CSR Pilot Review 2015 NIH ZRG1 MDCN-B (05) S, Drug Discovery for the Nervous System, Chair 2015 USAMRMC/CDMRP – Peer Review Panel, Pulmonary Fibrosis 2016 NIH ZRG1 NOMD-A, Ad Hoc Reviewer 2018 NIH ZRG1 CDIN, Ad Hoc Reviewer
International Review Service:
1992-93, Manitoba Health Research Council, Canada 1992-94 Swiss National Science Foundation 1999, 2002 Israel Science Foundation 1998-99 Manitoba Health Research Council, Canada 2003 Hong Kong Research Council 2006 New Zealand Neurologic Foundation 2007 National Medical Research Council (Singapore) 2008 ETH Zurich Research Commission, Switzerland 2008, 09 Stichting voor Alzheimer Onderzoek (SAO) - Fondation pour la Recherche sur la
Maladie Alzheimer (FRMA) 2010 Prinses Beatrix Fonds, Utrecht, The Netherlands 2016 Israeli Science Foundation 2018 German-Israeli Foundation for Scientific Research Editorial Boards Hepatology (1990-94) American J of Translational Research (2009-12) J Experimental Medicine (2010-17) Science Signaling (2010-) ACS Chemical Neuroscience (2018-) Memberships (past and current): American Association for the Advancement of Science American Society for Investigative Pathology American Society of Biochemistry and Molecular Biology American Association of Blood Banks American Society for Clinical Investigation College of American Pathologists Dallas County Medical Society North Texas Society of Pathologists
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Texas Medical Association Texas Society of Pathology Advisor to Graduate Students/Postdoctoral Fellows: Lee Ann MacMillan- M. S., 1990- Pharmacology, Tulane University Issac Rondon- Ph. D., 1993- Pharmacology, Tulane University Bing Carter, Ph.D., Postdoctoral fellow, 1990-‘91 Paul Gillis, BS, 1990-‘91 Ying Hong, MD, Postdoctoral Fellow, 1990-91 Charles Carroll- Ph. D., Cell and Molecular Biology, UW-Madison, 1994-‘96 (Recipient Howard Hughes Predoctoral Training Award, 1994-‘96) Jason Jarzembowski- Ph. D., Pathology, UW-Madison, 1998 (Recipient Molecular Biosciences Training Grant stipend, 1996-‘98) Hassan Zaidi, Ph. D., Postdoctoral Fellow, 1992-‘95 Laksman Rajagopolan, Ph. D., Postdoctoral Fellow, 1992-‘96 Rafat Abounar, M.D., Postdoctoral Fellow, 1994-‘95 Randy Horwitz, M.D., Ph. D., Postdoctoral Fellow, 1996- Cara Westmark Ph. D., Postdoctoral Fellow 1995- (Recipient Institute on Aging Training Grant Postdoctoral Fellowship, ‘96-’99) Saswati Bhattacharya Ph. D., Postdoctoral Fellow 1995-‘02 Larry Parnell Ph. D., Postdoctoral Fellow 1995-‘97 Stephane Esnault Ph. D., Postdoctoral Fellow 1997-‘02, Asst Scientist (‘02-‘08) Arlene Van Vliet Ph. D., Postdoctoral Fellow 1997-‘98 Matt Rank, UW-Madison undergraduate, 1997 (Recipient Howard Hughes/NSF Undergraduate Research Award) Jeff Ruth Ph. D., Postdoctoral Fellow, 1997-9 Rebecca Manitses Ph. D., Postdoctoral Fellow, 1997-8 Hyun Shin Ph.D., Postdoctoral Fellow, 1998-01 Syrus Soltaninassab Ph.D., Postdoctoral Fellow, 1999-‘02 (Recipient Institute on Aging Training Grant Postdoctoral Fellowship, ‘99-’02) Francoise Gourronc, Ph. D., Postdoctoral Fellow, 1999-‘01 Hisam Goueli, UW- Madison undergraduate, Senior Honor’s Thesis,
Molecular Biology, 1999-2000 Virginia Bartelson, UW-Madison undergraduate, Independent Research (2000-‘01) Virginia Bartelson, UW-Madison undergraduate, Senior Honor’s Thesis,
Molecular Biology, 2001-‘02 Peter Todd, MD/PhD candidate, Neuroscience Training Program, PhD awarded (’02)
Peter Spear, UW-Madison undergraduate, Independent Research, (2001) Maria Ujue Latasa, PhD Candidate, Department of Medicine,
University of Navarra Pamplona, Spain (2001) Dongzue Lu, Ph. D., Postdoctoral Fellow (‘01-‘02)
Amit Dande, PhD candidate, Pathology Graduate program (‘01-‘04), MS-Pathology, 2004
Pamela Westmark PhD, Postdoctoral Fellow (‘02-08), Asst Researcher (’08-‘11) (Recipient Institute on Aging Training Grant Postdoctoral Fellowship) Tajamul Hussain PhD, Postdoctoral Fellow (‘02-05)
Meggan Czapiga Ph.D., Postdoctoral Fellow (2002-03) Wenxue Ma, Ph.D., Postdoctoral Fellow (2004-05) Suqing Wang Ph.D,. Postdoctoral Fellow (2004-06) Brook Simon, MS, Cellular and Molecular Biology Program (2004-06) Keith Hanson, MD/PhD candidate (2007-08) Qifa Xie, Ph.D., Postdoctoral Fellow (2008-09) Haiyan Chu Ph.D., Postdoctoral Fellow (2008-11) Kelsey Stein, UW-Madison Undergraduate Research Scholar (2008-11) Brian Ray, UW-Madison Undergraduate (2008-11) Utibe Bickham, PhD candidate, Pathology Graduate program (2009-11)
(Recipient AOF scholarship and Biotechnology Training Grant support). Jiyoung Oh, Ph.D., Postdoctoral Fellow (2010-5) Berdy Hojayev, (2013-4) Nancy Stallings, Ph.D. (2014-) Melissa O’Neal, Ph.D. (2015-) Venkatesh Kashi, Ph.D. (2015-8) Thesis Committee Member: (UW) Sharash Rai, Dept of Pathology Graduate Program, Ph.D., ‘96 Seungbok Lee, Dept of Pathology Graduate Program, Ph.D., ‘97 Dan Streblow, Dept of Pathology Graduate Program, Ph.D.. ‘96 Rashid Mosavinasab, Dept of Pharmacology Graduate Program, Ph.D, ‘96 Yah Ma, Dept of Biochemistry Graduate Program, M.S., ‘94 Phil Watson, Cell and Molecular Biology Graduate Program, PhD, 2004 Paul Boyston, Cell and Molecular Biology Graduate Program, Ph.D., ‘97 Steve Schwarze, Cell and Molecular Biology Graduate Program, Ph.D., ‘97 Deborah Fuller, Dept of Pathology Graduate Program, Ph. D., 2000 Bianca Mothe, Dept of Pathology Graduate Program, Ph. D. 2002 Rebecca Aron, Biomolecular Chemistry Training Program, PhD, 2006 Thor Stein, Neuroscience Training Program, Ph.D., 2003 Alexandra Adriano. Biomolecular Chemistry Training Program, MS 2005 Haichen Dong, Cellular and Molecular Pharmacology, PhD, 2006 Melanie Molitor, Dept of Pathology Graduate Program, PhD, 2006 Andrea Weiler, Dept of Pathology Graduate Program, MS, 2006 Jill Schartner, Dept of Pathology Graduate Program 2005-‘11 Dan Kelley, Neuroscience Training Program, PhD, 2008. Erin Gonzalez, Genetics Graduate Program 2005-‘11 Nick Manoss, Pathology Graduate Program 2009, Ph.D., 2009 Hui Li, Neuroscience Training Program 2006-‘11 Melissa Harris, Neuroscience Training Program 2008-‘11 Phil Mudd, Cell and Molecular Biology Program, 2008-‘11
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Andrea Wilson, Pathology Graduate Training Program, PhD, 2009 Bahauddeen Alrfaei, Pathology Graduate Training Program, 2009-‘11 Toni Brand, Pathology Graduate Training Program, 2009-‘11 Thesis Committee Member: (UTSW)
Aakanksha Jain, Immunology Graduate Training Program 2013-6 Leonardo Estrada, Immunology Graduate Training Program 2013-7 Kuan-wen Wang, Immunology Graduate Training Program, 2015-8 Josiah Flaiming, Cancer Biology Training Program, 2018- Wenting Du, Cancer Biology Training Program, 2015-9.
Interdisciplinary Program Memberships: Molecular and Cell Biology Graduate Training Program, Tulane U (1990-91) Cell and Molecular Biology Graduate Training Program, UW (1991-2011) University of Wisconsin Comprehensive Cancer Center (1991-2011) Institute on Aging, University of Wisconsin (1991-2011) Neuroscience Graduate Training Program, UW (1991-2011) Biotechnology Training Program, UW (1991-2011) Cellular and Molecular Pathology Training Program (1991-2011) Hematology Training Program, UW (1998-2011) Cell Regulation Graduate Training Program, UTSW (2011-) Immunology Graduate Training Program, UTSW (2011-) Classroom Teaching: Tulane U. Medical School (1988-91): Sophomore Medical Student Pathology, 3-5 lectures/ yr (Flow Cytometry,
Laboratory Medicine and Molecular Biology of Disease) Pathology Residents-Blood Bank Rotation (4-6 months/ yr) Pharmacology Graduate Curriculum- Mechanisms of Disease (2 lectures/ yr) U Wisconsin (1991-2011): Pathology 750 (Graduate level), 6 lectures/yr (1992-2002) Pathology 709 (Graduate level), 2 lectures/yr (2000-11) Pathology Residents and Fellow, Blood Bank (4 months/ yr) (1991-2011) Course Director-Cell and Molecular Biology of Aging, Path 751 (3 credits), 6 lectures/y (2000-11) Course Director-MSTP 2nd year Journal Club (1 credit, Pathology 901) (2006-11) Pathology 803 (Graduate level), 2 lectures/yr (2006-11)
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Research funding, current:
2013-19 NIH P01 HL088594, Role of Eosinophils in Airway Inflammation and Remodeling, PI: N Jarjour; JS Malter Project 3 Leader, 20% effort. Direct Costs $300,000/y. Currently in No Cost Extension
Requested Direct Costs: $402,000/y 13%, 29 impact score.
2019-2024 NIH P01 HL088594, Role of Eosinophils in Airway Inflammation and Remodeling, PI: N Jarjour; JS Malter Project 3 Leader, 20% effort. Direct Costs $300,000/y.
Past individual or program project grant support:
1988-91 K08-CA-01427, Clinical Investigator Award, JS Malter PI. Total Direct Costs-$167,411.
1988-89 American Cancer Society Institutional Research Grant, JS Malter PI -$10,000.
1988-90 Tulane University Biomedical Research Support Grant, JS Malter PI, $15,000. 1990-91 LaSER/NSF Joint Colloquia Program, JS Malter PI, $5000.
1990-91 NIH-DK43434, Small Instrumentation Grant, JS Malter PI, Total Direct Costs - $27,500.
1991-95 NIH R01-DK45213, "Regulation of Hematopoietic Growth Factor Production". JS Malter PI (50% effort), Total Direct Costs: $440,905.
Co-Investigator, "Effects of EGF on Corneal Epithelium", Eye Bank Association of America, $6125.
1991-2007 NIH R01-AG10675-15, "APP mRNA Dysregulation and Alzheimer's Disease".
JS Malter PI (20% effort), Annual Direct Costs (last year) $225,000
1995-98 Advanced Technology Program, US Dept of Commerce to Symphony Pharmaceuticals, Malvern PA, Total Costs $1,700,000, JS Malter, subcontractor ($200,000 direct costs).
1996-2007 NIH SCOR-Asthma, P50HL56396-10, W. Busse Program Leader, JS Malter,
Project 5 Leader (20% effort). Total Direct Costs (10 years) $11,000,000: $220,000 Annual Direct Costs (final year) to JS Malter.
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1996-98 NIH R43CA75838, “Molecular Cloning of Unique Cytokines and
Protooncogenes”, T. Giordano PI, JS Malter Co-Investigator (5% effort), $100,000 direct costs.
1997-02 NIH R01-AA11148, “Ethanol Mediated Osteoporosis and Interleukin 6”, E.
Keller PI, JS Malter Co-Investigator (10% effort), Total Direct Costs $743,908. 1998-2001 NIH R01-MH61666, “Cloning of Early Response Genes from the Nervous
System”, JS Malter PI (20% effort), Total Direct Costs $500,000. 2000-04 NIH RO1-HL64812, “Mechanisms of Nocturnal Asthma”, N. Jarjour PI, JS
Malter, Co-I (5% effort), Total Direct Costs, $900,000 2001-06 NIH Allergic Disease Center, P01AI50500, W.W. Busse PI, JS Malter Project 4
Leader (20% effort), Total Direct Costs $3,200,000, $140,000 Annual Direct Costs to J.S. Malter.
$275,000 total direct costs. 2008-09 Institute for the Study of Aging (ISOA), JS Malter PI, 10% effort, $98,000 total
direct costs. 2008-10 FRAXA, Utilization of Fenobam to Reduce APP and Abeta in Fragile X Mice, C
Westmark PI, JS Malter Co-I (5% effort), $60,000/y direct costs. 2008-10 FRAXA, supplement, JS Malter PI, $10,000 direct costs. 2006-11 NIH P30 HD03352-44, Intellectual and Developmental Disabilities Research
Center (IDDRC) (PI, M Seltzer; JS Malter, Associate Director, 10% total effort) Annual Direct Costs $1,100,000.
2008-12 NIH R01 HL087950, Pin1 regulation of prosurvival signaling in eosinophils, JS
Malter PI, 20% effort, $250,000 annual direct costs 2009-12 NIH R01 DA026067, Pin1 in Synaptic Plasticity and Translation, JS Malter PI,
15% effort, $250,000/y 2009-14 NIH P50 AG033514-01 (S. Asthana, PI)-Wisconsin Alzheimers Disease Research
Center, JS Malter Co-Director Neuropathology Core, 5% effort.
Publications (Peer Reviewed): 1. Scornik, O., Ledbetter, M. and Malter, J.S., “Role of Aminoacylation of Histidyl-tRNA in the
Regulation of Protein Degradation in Chinese Hamster Ovary Cells”, J Biol Chem., 255(13):6322-27, 1980.
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2. Malter, J.S., Mannoti, S., Knee, G., Goodman, D.B.P. and Strauss, J., “Identification of Hyperthyroid Patients by Means of a Sensitive Assay for Thyrotropin”, Clin Chem, 31(4):642-44, 1985.
3. Malter, J.S., Reed, J.C. and Kamoun, M., “Induction and Regulation of CD2 mRNA in Human T Lymphocytes,” J Immunology, 140:3233-6, 1988.
4. Malter, J.S., “Identification of a Novel AUUUA Specific, mRNA Binding Protein”, Science,
246:664-666, 1989.
5. Malter, J.S. and Gerber, M.A., “Regulation of Hepatocyte Gene Expression: Progress on the Horizon”, Hepatology, 10:1017-1018, 1989.
6. Lapeyrolerie, J., Avent, J., Malter, J.S. and Hellstrom, W.J., “Standardization of fine needle aspiration biopsy of human testes using DNA Flow Cytometry”, Surgical Forum, 36, 1990.
7. Lauer, S., Malter, J.S. and Meier, R., “Human Papillomavirus Type 18 in Conjunctival Intra-Epithelial Neoplasia”, Am J Opthalmology, 110:23-27, 1990.
8. Lampertico, P., Malter, J.S., Colombo, M. and Gerber, M.A., “Detection of Hepatitis B virus
(HBV) DNA in formalin-fixed, paraffin-embedded liver tissue by Polymerase Chain Reaction (PCR)”, Am J Pathology, 137:253-258, 1990.
9. Malter, J.S., Moulton, D., Makni, H., Kant, J. and Kamoun, M., “Detection of CD2 Polymorphism on Chromosome 1 with EcoR1”, Nucleic Acids Research 18(21):6465, 1990.
10. Malter, J.S., Wilson, M., McCrory, W.A. and Gillis, P., The Adenosine-Uridine Binding Factor Requires Metals for Binding to Granulocyte-Macrophage Colony Stimulating Factor mRNA, Enzyme, 44(1-4), 203-13, 1990.
11. Malter, J.S. and Hong, Y., A Redox Switch and Phosphorylation are Involved in the Posttranslational Upregulation of the Adenosine-Uridine Binding Factor by Phorbol Ester and Ionophore, J Biol Chem. 266(5):3167-3171, 1991.
12. Gillis, P. and Malter, J.S., The Adenosine-Uridine Binding Factor Recognizes the AU-rich Elements of Cytokine, Lymphokine and Oncogene mRNAs, J Biol Chem. 266(5):3172-3177, 1991.
13. Malter, J.S. and Gerber, M. A., “The Polymerase Chain Reaction for Hepatitis B Virus DNA”, Hepatology 13:188-190, 1991.
14. Thompson, H.W., Malter, J.S., Steinemann, T.L and Beuerman, R., “Flow Cytometric Measurements of DNA Content of Corneal Epithelia Cells During Wound Healing”, Inv Opthal Vis Sci, 32(2):433-436, 1991.
15. Lampertico, P., Malter, J.S. and Gerber, M.A., “Development and Application of an In Vitro Model for Screening Anti-Hepatitis B Virus Therapeutics”, Hepatology, 13(3), 422-27, 1991.
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16. Makni, H., Malter, J.S., Reed, J.C., Nobuhiko, S., Lang, G., Kioussis, D., Trinchieri, G. and Kamoun, M., “The Reconstitution of an Active Surface CD2 by DNA Transfer in CD2-CD3+ Jurkat Cells Facilitates CD3-TCR Mediated IL2 Production”, J Immunology 146, 2522-29, 1991.
17. Rondon, I. J., MacMillan, L.A., Beckman, B. S., Goldberg, M.A., Scheider, T., Bunn, H.F. and
Malter, J. S., “Hypoxia Upregulates the Activity of a Novel Erythropoietin mRNA Specific Binding Protein”, J Biol Chem., 266(25), 16594-98, 1991.
18. Sullivan, D. and Malter, J. S., “A Rapid and Inexpensive Method for the Addition of Poly A Coding Tracts to Transcription Vectors”, Biotechniques, 11(5), 614-5, 1991.
19. Carter, B.C. and Malter J.S., “Regulation of mRNA Stability and Its Relevance to Disease”, Lab Invest, 65(6): 610-621, 1991.
20. Akyol, G., Dash, S., Shieh, C., Malter, J.S. and Gerber, M.G., “Detection of Hepatitis C Virus RNA Sequences by PCR in Fixed Liver Tissues”, Modern Pathology, 501-4, 1992.
21. Stephens, J., Carter, B.Z., Pekala, P. and Malter J.S., “Tumor Necrosis Factor-Alpha Induced Glucose Transporter (Glut-1) mRNA Stabilization in 3T3-L1 Preadipocytes: Regulation by the Adenosine-Uridine Binding Factor (AUBF)”, J Biol Chem., 267(12), 8336-41, 1992.
22. Gogu, S.R., Malter, J.S. and Agrawal, K.C., “Zidovudine (AZT) Induced Blockade of the Expression and Function of the Erythropoietin Receptor”, Biochem Pharm, 44, 1009-1012, 1992.
23. Lopez, J.G., Chew, S.J., Thompson, H.W., Malter, J.S., Insler, M.S., Beuerman, R.W., “EGF Cell Surface Receptor Quantitation on Ocular Cells by an Immunocytochemical Flow Cytometry Technique”, Invest Opthal and Vis Sci, 33(6), 2053-62, 1992.
24. Hamilton, B.J., Nagy, E., Malter, J.S., Arrick, B.A. and Rigby, W.F.C., “Association of hnRNP A1 and C proteins with reiterated AUUUA sequences”, J Biol Chem, 268(12), 8881-7, 1993.
25. Zaidi, S.H., Denman, R and Malter, J.S., “Multiple Proteins Interact at a Unique Cis-Element in
the 3' UTR of Amyloid Precursor Protein (APP) mRNA”, J Biol Chem, 269, 24000-7, 1994.
26. Rajagopalan, L. and Malter J.S., “GM-CSF mRNA is Stabilized In Vitro by the Adenosine Uridine Binding Factor”, J Biol Chem, 269, 23882-8, 1994.
27. Zaidi, S.H. and Malter J.S., “Amyloid Protein Precursor mRNA Stability is controlled by a 29 base Element in the 3’ Untranslated Region”, J Biol Chem, 269, 24008-13, 1994.
28. Voelkerding, K., Zaidi, H., Steffen, D., and Malter, J.S., “p53 mRNA is Regulated at the Posttranscriptional Level in Mitogen Stimulated Peripheral Blood Mononuclear Cells”, Oncogene, 10, 515-21, 1995.
29. Zaidi, H. and Malter J. S., “Cytoplasmic Nucleolin and hnRNP C Proteins Interact with a 3’ UTR Instability Element of APP mRNA”, J Biol Chem., 270, 17292-98, 1995.
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30. Rajagopalan, L., Burkholder, J., Turner, J., Decker, J., Yang, N.-S., and Malter, J. S., “GM-CSF mRNA Stabilization Enhances Transgenic Expression in Normal Cells and Tissues”, Blood, 86:2551-8, 1995.
31. Keller, E., Burkholder, J., Shi, F., Pugh, T., McCabe, D., Malter, J. S., MacEwen, G., Yang, N.-
S., and Ershler, W., “In Vivo Particle Mediated Cytokine Gene Transfer into Canine Mucosa and Epidermis”, Cancer Gene Therapy, 3(3), 186-91, 1996.
32. Mahvi, D, Burkholder, JK, Turner, J, Culp, J, Malter JS, Sondel, PS, Yang, NS, “Particle Mediated Gene Transfer of GM-CSF cDNA to Tumor Cells: Implications for a Clinically Relevant Tumor Vaccine, Human Gene Therapy 7, 1535-43, 1996.
33. Rajagopalan, L. and Malter J.S., “Degradation and Translation of In Vitro Synthesized mRNAs Transfected into Normal Peripheral Blood Mononuclear Cells”, J Biol Chem, 271(33):19871-6, 1996.
34. Jacobs D., Giordano, T., Xue-Hu, I., Malter, J.S., Synder, A.K. and Singh, S., “AUUUA-Specific mRNA Binding Protein in Astrocytes”, Life Sciences, 58(23), 2083-9, 1996.
35. Malter JS, “Posttranscriptional Regulation of Genes Important for T lymphocyte Function”, Advances in Immunology, Ed. F Dixon, Academic Press, 1998.
36. Rajagopalan L, Westmark, C, Jarzembowski, J and Malter JS, “hnRNP C Increases APP Production by stabilizing APP mRNA”, Nucleic Acids Research 26, 3418-23, 1998.
37. Trivedi V, Guillery E, and Malter JS, “Pediatric anti-glomerular basement membrane glomerulonephritis, J of Clinical Apheresis. 13(2):69, 1998.
38. Esnault S, Jarzembowski J and Malter JS, “Ionophore Mediated Stabilization of GM-CSF mRNA in Eosinophils Requires the AUUUA Motifs”, J Assoc Amer Phys, 110, 575-84, 1998.
39. Jarzembowski JA. Rajagopalan LE. Shin HC. Malter JS, “The 5'-untranslated region of GM-CSF mRNA suppresses translational repression mediated by the 3' adenosine-uridine-rich element and the poly(A) tail”, Nucleic Acids Research 27(18):3660-6, 1999.
40. Bhattacharya S, Giordano T, Brewer G and Malter JS, “Identification of AUF1 Ligands Reveals a Wide Diversity of Early Response Gene mRNAs”, Nucleic Acids Research, 27, 1464-72, 1999.
42. Ruth J, Esnault S, Jarzembowski J, Malter JS, “Calcium ionophore upregulation of AUUUA specific binding proteins is contemporaneous with GM-CSF mRNA stabilization in AML.3D10 cells”, American J of Resp Cell and Mol Biol, 21(5):621-8, 1999.
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43. Rajagopolan L, Malter JS, Growth factor mediated Stabilization of Amyloid Precursor Protein mRNA is Mediated by a Conserved 29-Nucleotide Sequence in the 3’UTR, J Neurochemistry, 74, 52-9, 2000.
44. Westmark C and Malter JS, “ERK controls βAPP mRNA decay”, Mol Brain Res, 20;90(2):193-201, 2001.
46. Bhattacharya S, Gordon B, Bates ME, Bertics P, Malter JS, ”Stat5 is Upregulated and Phosphorylated by GM-CSF and IL-5 in Eosinophils”, American J of Resp Cell and Mol Biol, 24(3):312-6, 2001.
47. Westmark C and Malter JS, ”Regulation of Nucleolin mRNA and Protein by Multiple Signaling Pathways”, J Biol Chem., 276(2):1119-26, 2001.
48. Esnault S and Malter JS, “Transfection of Eosinophils Reveals Nominal Requirement for GM-CSF”, J Interferon and Cytokine Res, 21(2):117-24, 2001.
49. Esnault S and Malter JS, “GM-CSF mRNA is stabilized in airway eosinophils and peripheral blood eosinophils activated by TNF-α plus fibronectin”, J Immunology, 166:4658-63, 2001.
50. Malter JS ”mRNA decay in the Central Nervous System and Beyond”, J Neuroscience Res, 66(3):311-6, 2001.
52. Esnault S, Malter JS, “GM-CSF Regulation in Eosinophils”, Archivum Immunologiae et Therapiae Experimentalis, 50(2), 2002.
53. Todd P.K. and Malter JS., “Fragile X Mental Retardation Protein in Plasticity and Disease”, J
Neuroscience Res, 70(5):623-30, 2002.
54. Todd PK., Malter JS. and Mack KJ. “Whisker stimulation-dependent translation of FMRP in the barrel cortex requires activation of type I metabotropic glutamate receptors”. Brain Research, Molecular Brain Research. 110(2):267-78, 2003.
55. Todd PK, Mack KJ, Malter JS.” The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95”. PNAS-USA 100(24): 14374-8, 2003.
56. Esnault S, Malter JS. “Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins”. J Immunology 171(12):6780-7, 2003.
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57. Gern JE, Brockman-Schneider R, Bhattacharya S, Malter JS, Busse WW. “Serum and low-density lipoprotein enhance interleukin-8 secretion by airway epithelial cells”. American J Respir Cell and Mol Biol. 29(4):483-9, 2003.
58. Bates ME, Liu LY, Esnault S, Stout BA, Fonkem E, Kung V, Sedgwick JB, Kelly EA, Bates DM, Malter JS, Busse WW, Bertics PJ, “Expression of IL-5- and GM-CSF-responsive genes in blood and airway eosinophils”. American J Respir Cell and Mol Biol, 30(5):736-43, 2004.
59. Broytman O, Malter JS. ”Aβ: The good, the bad, and the unforeseen”. J Neuroscience Res. 75:301-6, 2004.
60. Nakamura Y, Esnault S, Maeda T, Kelly EA, Malter JS, Jarjour NN. “Ets-1 regulates TNF-alpha-induced matrix metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts”. J Immunology Feb 1;172(3):1945-52. 2004.
61. Voss CY, Albertini MR, Malter JS. “Dendritic cell-based immunotherapy for cancer and relevant challenges for transfusion medicine”. Transfusion Med Rev. 18(3):189-202, 2004.
62. Westmark CJ, Bartleson VB, Malter JS. “RhoB mRNA is stabilized by HuR after UV light”. Oncogene 13;24(3):502-11, 2005.
63. Shen ZJ, Esnault S, Malter JS. “The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils”. Nature Immunology 6(12):1280-7, 2005. [Accompanying Editorial].
64. JL Lauer, JL Shohet, RM Albrecht, C. Pratoomtong, R. Murugesan, S. Esnault, JS Malter, U H von Andrian, RD Bathke, and SB Shohet,” Reduced adhesion of human blood platelets to polyethylene tubing by microplasma surface modification,” J of Applied Physics, 96 4539-4546, 2004.
67. JL Lauer, JL Shohet, RM Albrecht, S Esnault, JS Malter, UH von Andrian, and SB Shohet, “Control of Uniformity of Plasma-Surface Modification Inside of Small-Diameter Polyethylene Tubing Using Microplasma Diagnostics”, IEEE Transactions on Plasma Science, 33(2), 2005.
68. S Esnault, Zhong-Jian Shen, Emily Whitesel, and JS Malter, “Pin1 Regulates Granulocyte Macrophage-Colony Stimulating Factor mRNA Stability in T Lymphocytes”, J Immunology, 177(10):6999-7006, 2006.
69. R. K. Braun, S Esnault, Zhong-Jian Shen, Zhuzai Xiang, RB Love, E. Heninger, M. Sandor, JS Malter, “Pin1 Regulates Type I Immune Responses”, PloS One, 2(2):e226, 2007.
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70. Esnault, S, Kelly, B, Malter JS, Jarjour N, “Circadian Changes in Granulocyte Macrophage Colony-Stimulating Factor Message and YB-1 Binding Activity in Circulating Eosinophils, Annals of Allergy, Asthma and Immunology, 98(1):75-82, 2007.
71. C. Westmark and JS Malter, “FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein”, PloS Biology, 5(3):e52, 2007. [Accompanying Editorial].
72. Wang DS, Dickson DW, Malter JS. “β-Amyloid Degradation and Alzheimer's Disease”. J Biomed Biotechnol; 3:58406, 2006.
73. Wang S, Simon BP, Bennett DA, Schneider JA, Malter JS, Wang DS. “The significance of Pin1 in the development of Alzheimer's disease”. J Alzheimers Dis; 11(1):13-23, 2007.
74. Shen ZJ, Kim SK, Jun do Y, Park W, Kim YH, Malter JS, Moon BJ. “Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells”. Exp Cell Res; 313(7):1415-25, 2007.
75. Esnault, S, Rosenthal, LA, Zhong-Jian Shen, Sedgwick, JB, Szakaly, RJ, Sorkness, RL, & Malter JS, “A Critical Role for Pin1 in Allergic Pulmonary Eosinophilia in Rats”, J Allergy Clin Immunology; 120(5):1082-8, 2007.
76. Esnault, S, Shen Z-J and Malter JS, “Pinning Down Signaling in the Immune System, The Role of Peptidyl-Prolyl Isomerase Pin1 in Immune Function”, Critical Reviews in Immunology, 28(1):45-60, 2008.
77. Shen ZJ, Esnault S, Rosenthal LA, Szakaly RJ, Sorkness RL, Westmark PR, Sandor M, and Malter JS, “Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis”, J Clinical Investigation; 118(2):479-90 2008. [Accompanying Editorial].
78. Wang DS, Dickson DW and Malter JS,” Tissue Transglutaminase, Protein Cross-linking and Alzheimer’s Disease: Review and Views.” Int J Clin Exp Pathol 1(1):5-18, 2008.
79. Westmark C, Westmark PR, Beard AM, Hildebrandt S and Malter JS, “Seizure Susceptibility and Mortality in Mice that Over-Express Amyloid Precursor Protein.” Int J Clin Exp Pathol 1(2):157-168, 2008.
80. Esnault S, Rosenthal LA, Wang DS and Malter JS,” Thymus Stromal Lymphopoietin (TSLP) as
a Bridge between Infection and Atopy.” Int J Clin Exp Pathol 1(4):325-330, 2008.
83. Young KH, Leroy K, Møller MB, Colleoni GW, Sánchez-Beato M, Kerbauy FR, Haioun C, Eickhoff JC, Young AH, Gaulard P, Piris MA, Oberley TD, Rehrauer WM, Kahl BS, Malter JS, Campo E, Delabie J, Gascoyne RD, Rosenwald A, Rimsza L, Huang J, Braziel RM, Jaffe ES, Wilson WH, Staudt LM, Vose JM, Chan WC, Weisenburger DD, Greiner TC. “Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study”. Blood. Oct 15;112(8):3088-98, 2008.
84. Broytman O, Westmark PR, Gurel Z, Malter JS. “Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines”. Neurobiol Aging. Mar 28, 2008.
85. Wang R, Wang S, Malter JS, Wang DS, “Effects of 4-Hydroxy-Nonenal and Amyloid-beta on Expression and Activity of Endothelin Converting Enzyme and Insulin Degrading Enzyme in SH-SY5Y Cells”. J Alzheimers Dis. Apr 10, 2009.
86. Wang R, Wang S, Malter JS, Wang DS, “Effects of HNE-modification induced by Abeta on
neprilysin expression and activity in SH-SY5Y cells”. J Neurochemistry. 108(4):1072-82, 2009.
87. Oczko-Walker M, Manousakis G, Wang S, Malter JS, Waclawik AJ. Plasma exchange after
initial intravenous immunoglobulin treatment in Guillain-Barré syndrome: critical reassessment of effectiveness and cost-efficiency. J Clin Neuromuscul Dis. Dec;12(2):55-61, 2010.
88. Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS. “The peptidyl-prolyl isomerase Pin1
facilitates cytokine-induced survival of eosinophils by suppressing Bax activation”. Nature Immunology, 10(3):257-65, 2009. [Cover Photograph].
89. Wang R, Malter JS, Wang DS. “N-Acetylcysteine Prevents 4-Hydroxynonenal- and Amyloid-
beta-Induced Modification and Inactivation of Neprilysin in SH-SY5Y Cells”. J Alzheimers Dis. 2009 Sep 11.
90. Oczko-Walker M, Manousakis G, Wang S, Malter JS, Waclawik AJ. Plasma exchange after initial intravenous immunoglobulin treatment in Guillain-Barré syndrome: critical reassessment of effectiveness and cost-efficiency. J Clin Neuromuscul Dis. 2010 Dec;12(2):55-61. doi: 10.1097/CND.0b013e3181f3dbbf.
91. Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, Raad H, Arabi Derkawi R, Bournier O, Kroviarski Y, Zhou XZ, Malter JS, Lu PK, Bartegi A, Dang PM, El-Benna J., The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. Blood. 2010 Dec 23;116(26):5795-802. doi: 10.1182/blood-2010-03-273094. Epub 2010 Oct 18.
92. Westmark P, Westmark C, Wang SQ, Levenson JM, O’Reardon, K, Burger, C, and Malter JS, “Dendritic Protein Synthesis and Synaptic Plasticity are Sequentially Regulated by Pin1 and PKMζ”, Science Signaling, Mar 9;3(112):ra18, 2010, [Accompanying Editorial].
93. Malter, JS, Westmark PR, and Westmark CJ, “Fragile X Syndrome and Alzheimer’s Disease: Another Story About APP and b-amyloid”, Current Alzheimers Research, Jan 21, 2010.
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94. Reese, S, A Vidyasagar, L Jacobson, Z Acun, S Esnault, D Hullett, JS Malter and A Djamali,
“The Pin 1 inhibitor juglone attenuates kidney fibrogenesis via Pin 1 independent mechanisms in the unilateral ureteral occlusion model”, Fibrogenesis & Tissue Repair, Jan 4;3(1):1, 2010.
96. Westmark CJ, PR Westmark, CM Hervey, MS Salamat, KM Stein, BC Ray, LA Stodola, M Tranfaglia, K Huber, EM Berry-Kravis and JS Malter, “Reversal of Fragile X Phenotypes by Manipulation of APP/Ab Levels.” PLoS One. 2011;6(10):e26549. Epub 2011.
97. Westmark CJ, PR Westmark and JS Malter “MPEP Reduces Seizure Severity in Fmr-1 KO Mice Over Expressing Human Aβ” Int J Clin Exp Pathol 3, 1-14, 2010.
98. Boussetta T, Gougerot-Pocidalo MA, Hayem G, Ciappelloni S, Raad H, Arabi Derkawi R, Bournier O, Kroviarski Y, Zhou XZ, Malter JS, Lu PK, Bartegi A, Dang PM, El-Benna J. The prolyl isomerase Pin1 acts as a novel molecular switch for TNF{alpha}-induced priming of the NADPH oxidase in human neutrophils. Blood. Dec 23;116(26):5795-5802, 2010.
99. Westmark CJ, Hervey CM, Berry-Kravis EM, Malter JS. Effect of Anticoagulants on Amyloid β-Protein Precursor and Amyloid Beta Levels in Plasma. J Alzheimers Dis Parkinsonism. 2011 Jul 24;1:101.
100. Westmark PR, Westmark CJ, Jeevananthan A, Malter JS. Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient. J Vis Exp. 2011 Sep 17;(55). pii: 3196. doi: 10.3791/3196.
101. Rangasamy V, Mishra R, Sondarva G, Das S, Lee TH, Bakowska JC, Tzivion G, Malter JS,
Rana B, Lu KP, Kanthasamy A, Rana A. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci USA. 2012 Epub 2012 May 7.
102. Westmark CJ, Malter JS. The regulation of AβPP expression by RNA-binding proteins. Ageing
Res Rev. 2012 Apr 5. 103. Shen ZJ, Braun RK, Hu J, Xie Q, Chu H, Love RB, Stodola LA, Rosenthal LA, Szakaly RJ,
Sorkness RL, Malter JS. Pin1 protein regulates Smad protein signaling and pulmonary fibrosis. J Biol Chem. 2012 Jul 6;287(28):23294-305. doi: 10.1074/jbc.M111.313684. Epub 2012 May 21.
105. Shen ZJ, Hu J, Ali A, Pastor J, Shiizaki K, Blank RD, Kuro-o M, Malter JS. Pin1 null mice exhibit low bone mass and attenuation of BMP signaling. PLoS One. 2013 May 10;8(5):e63565. doi: 10.1371/journal.pone.0063565. Print 2013.
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106. Esnault S, Kelly EA, Schwantes EA, Liu LY, DeLain LP, Hauer JA, Bochkov YA, Denlinger LC, Malter JS, Mathur SK, Jarjour NN. Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge. PLoS One. 2013 Jul 2;8(7):e67560. doi: 10.1371/journal.pone.0067560. Print 2013.
107. Esnault S, Kelly EA, Johansson MW, Liu LY, Han ST, Akhtar M, Sandbo N, Mosher DF,
Denlinger LC, Mathur SK, Malter JS, Jarjour NN. Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol. 2014 Jan;150(1):90-100. doi: 10.1016/j.clim.2013.11.009. Epub 2013 Nov 23.
108. Westmark CJ, Westmark PR, Malter JS. Soy-based diet exacerbates seizures in mouse models of
109. Rakhja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatrude JF. Somatic Mutation in DORSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Nature Commun. 2014 Sept 5; 2:4802. Doi: 10.1038/ncomms5802.
110. Shen ZJ, Malter JS. Determinants of eosinophil survival and apoptotic cell death. Apoptosis. 2015 Feb; 20(2):224-34. Doi: 10.1007/s10495-014-1072-2.
111. Shen ZJ, Malter JS. XBP1, a determinant of the eosinophil lineage, Nature Immunol. 2015 Jul 21;16(8):793-4. doi: 10.1038/ni.3214.
112. Shen ZJ, Hu J, Esnault S, Dozmorov I, Malter JS. RNA Seq profiling reveals a novel expression pattern of TGF-β target genes in human blood eosinophils. Immunol Lett. 2015 Jun 22;167(1):1-10. doi: 10.1016/j.imlet.2015.06.012. [Epub ahead of print]
113. Shen ZJ, Malter JS Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1. Biomolecules. 2015 Apr 14;5(2):412-34. doi: 10.3390/biom5020412.
114. Esnault, SE, Kelly, B, Johannson M, Malter JS, Jarjour N, IL-3 maintains activation of the
P90S6K/RPS6 pathway and increases translation in human eosinophils, J Immunology, 2015 Sep 15;195(6):2529-39
115. Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH. The DNA
Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense. Cell Rep. 2015 Dec 1;13(9):1922-36.
116. Shen ZJ, Hu J, Shiizaki K, Kuro-o M, Malter JS. Phosphate-Induced Renal Fibrosis Requires the
Prolyl Isomerase Pin1, PLoS One. 2016 Feb 25;11(2):e0150093. 117. Sosa LJ, Malter JS, Hu J, Bustos Plonka F, Oksdath M, Nieto Guil AF, Quiroga S, Pfenninger
KH. Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization, J Neurochem. 2016 Jun;137(5):744-55.
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118. Kelly EA, Esnault S, Johnson SH, Liu LY, Malter JS, Burnham ME, Jarjour NN. Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF. Immunol Cell Biol. 2016 Aug;94(7):701-8.
119. Shen ZJ, Hu J, Kashi VP, Kelly EA, Denlinger LC, Lutchman K, McDonald JG, Jarjour NN,
Malter JS. Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1576-1585.
Colorectal Tumorigenesis via Downregulation of the TLR Pathways. Cell Rep. 2017 Jun 27;19(13):2756-2770.
121. Sacchi V, Wang BJ, Kubli D, Martinez AS, Jin JK, Alvarez R Jr, Hariharan N, Glembotski C, Uchida T, Malter JS, Yang Y, Gross P, Zhang C, Houser S, Rota M, Sussman MA. Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic ReticulumCalcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function. J Am Heart Assoc. 2017 Oct 10;6(10). pii: e006837. doi: 10.1161/JAHA.117.006837.
122. Esnault S, Shen ZJ, Malter JS. Protein Translation and Signaling in Human Eosinophils. FrontMed (Lausanne). 2017 Sep 19;4:150.
123. Richardson TE, Shen ZJ, Kanchwala M , Xing C, Filatenkov A, Shang P, Barnett S, AbedinZ, Malter JS, Raisanen JM, Burns DK, White CL, Hatanpaa KJ. Aggressive Behavior in Silent Subtype III Pituitary Adenomas May Depend on Suppression of Local Immune Response: A Whole Transcriptome Analysis. J Neuropathol Exp Neurol. 2017 Oct 1;76(10):874-882.
124. Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ. Sampling strategies to capture single-cell heterogeneity. Nat Methods. 2017 Oct;14(10):967-970.
125. Stalling NR, O'Neal, MA, Hu, J, Kavalali, ET, Bezprozvanny, I, Malter JS, Pin1 mediates Aβ42-induced dendritic spine loss., Science Signaling, 2018 Mar 20;11(522).
126. O'Neal MA, Stallings NR, Malter JS. Alzheimer's Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach? ACS Chem Neurosci. 2018 May 14
127. Shen ZJ, Hu J, Kashi V, Bochkov YA, Gern JE, Malter JS. TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1. J Immunol. 2018 Nov 5. pii: ji1800881. PMID: 30397031
Meeting Abstracts (over 120 total, not listed): Book Chapters: 1. Jarzembowski, J. and Malter, J. S., “Identification and Role of AUUUA-Specific mRNA Binding
Proteins”, in Cytoplasmic Fate of Eukaryotic mRNA, P. Jeanteur Ed., Springer-Verlag, Heidelberg, 1996.
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2. Rajagopalan, L and Malter, J.S., “mRNA Stability in the Control of Gene Expression”, in Progress in Nucleic Acid Research and Molecular Biology, W.E. Cohn and K. Moldave Eds., Academic Press, Orlando, Fl, 1997.
3. Rajagopalan, L, Yang, N.S. and Malter, J.S, “Particle Mediated mRNA Transfer”, in Transgene Delivery and Expression in Mammalian Cells, Methods in Molecular Biology, JM Walker, Editor, Humana Press, 1997.
4. Westmark C and Malter J.S., “Translating Memories: The Role of Protein Biosynthesis in Synaptic Plasticity”, in Protein Biosynthesis, TE Esterhouse and LB Petrinos, Editors, Nova Biomedical, 2009
5. Bickham, U and Malter JS, “Apoptotic and survival signaling in eosinophils”, in Eosinophils in Health and Disease, Eds. H Rosenberg and JJ Lee, Elsevier, 2012.
Other: Malter J. S., Contributing Reviewer, University Hospital Consortium Technology Advancement Center, “Technology Report: Albumin”. UHC, Nov., 1992. Malter J.S., Contributing Reviewer, University Hospital Consortium Technology Advancement Center, “Technology Assessment: Platelet Transfusion Guidelines”, UHC, 1998. U.S. Patents: #5,587,300, “Method to Increase Regulatory Protein Production”, issued to JS Malter, 1996 #20090053209, “Blockade of Pin1 Prevents Cytokine Production by Activated Immune Cells” issued to JS Malter, Feb., 2009. Lectures by Invitation: 1985 Dept of Pathology & Laboratory Medicine, University of Pennsylvania, School of Medicine. 1986 Dept of Pathology & Laboratory Medicine, University of Pennsylvania, School of Medicine 1987 Imperial Cancer Research Fund, London, England. Dept of Pathology & Laboratory Medicine, University of Pennsylvania, School of Medicine, Academy of Clinical Laboratory Physicians and Scientists, Annual Meeting, Phil, PA. 1988 Frontiers in Pathology, Dept of Pathology, Mt. Sinai School of Medicine, NY, NY. Dept of Pathology, University of Rochester School of Medicine.
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Dept of Pathology, Tulane University Medical School, New Orleans, LA. Dept of Biochemistry/Molecular Biology, Louisiana State University Medical Center, NO, LA 1989 "Current Topics in OB-GYN", Update on Human Papilloma Virus, CME Update-Dept of
OB/GYN, Tulane Medical Center, New Orleans, LA. Translational Control, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY Dept of Microbiology and Immunology, Tulane U. School of Medicine 1990 Dept of Physiology, LSU Medical Center, New Orleans, LA. Dept of Biochemistry, Tulane U. School of Medicine
VIII Scientific Meeting, Anatomic Pathology Department, University of Zulia, Maracaibo, Venezuela.
Dept of Pathology CME Update Seminar, Tulane University Medical School. Dept of Pathology, Pennsylvania State University, M.S. Hershey Medical Center, Hershey, PA. Dept of Pathology, Northwestern University School of Medicine, Chicago, IL. 1991 Dept of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. Transfusion Medicine Update, Rapides Medical Center, Alexandria, LA Institute for Medical Microbiology, University of Basel, Basel, Switzerland Dept of Pathology, University of Wisconsin, School of Medicine, Madison, WI Laboratory of Molecular Oncology, National Cancer Institute, Fredrick, MD "Alzheimer's Disease and Related Neurodegenerative Disorders", AAP, FASEB, Atlanta, GA Dept of Pathology CME Update Seminar, Tulane University Medical School, New Orleans, LA. Dept of Medicine, Division of Hematology, U of Wisconsin Hospital and Clinic, Madison, WI 1992 Dept of Human Oncology, U of Wisconsin Cancer Center
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Dept of Physiology, U of North Carolina, Chapel Hill, NC Dept of Biochemistry, East Carolina Medical School, Greenville, NC Aging Institute, U of Wisconsin Medical School, Madison, WI "Transfusion in the 90's", Mercy Medical Center, Oshkosh, WI Medical Technology Training Program, U of Wisconsin Medical School, Madison, WI Dept of Medicine, Dartmouth Medical School, Hanover, NH Dept of Nutrition Sciences, U of Wisconsin, Madison, WI Transfusion Transmitted Disease, Rational Blood Use-CME Course, Department of Medicine, U
of Wisconsin, Madison, WI CME Course-Transfusion in the 90's, Waupun Medical Center, Waupun, WI CME Course-Transfusion Transmitted Disease, Watertown Med Center, Watertown, WI Dept of Cell and Molecular Biology, U of New Mexico, Alburqurque, NM 1993 Dept of Mammalian Genetics, Agracetus Inc, Madison, WI Dept of Pathology, Georgetown University School of Medicine, Wash. D.C. Dept of Pathology, Tulane U. School of Medicine, NO, LA Dept of Pathology, UTMB, Galveston, TX Dept of Pathology, U of Pittsburgh, Pittsburgh, PA Division of Neuroscience, Abbott Laboratories, Abbott Park, IL Division of Immunology, Pfizer Pharmaceuticals, Groton, CT 1994 Division of Laboratory Medicine, Department of Pathology, UW-Madison Immunology Colloquia, UW-Madison Combined Pediatrics/Medicine Critical Care Conference, UWHC, "Massive Transfusion" Institute for Inflammation and Experimental Medicine, Miles Labs, West Haven, CT Masters in Oncology, UW Comprehensive Cancer Center, UW Medical School
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12th Critical Care Symposium, U of Wisconsin Med School, "Massive Transfusion in Trauma” 1995 Biotherapy/Immunology Colloquia, UW-Madison Medical School Dept of Pathology/Laboratory Medicine, UW-Madison Medical School Dept of Pathology/Lab Medicine, U of Rochester School of Medicine, Rochester, NY Dept of Pathology/Lab Medicine, Tulane University School of Medicine, NO, LA Dept of Molecular Biology, Symphony Pharmaceuticals, Malvern, PA Division of Lab Medicine, Dept of Pathology, U Wisconsin Medical School Dept of Pathology, Cornell U Medical School. NY, NY
Dept of Biology, Northern Illinois University, Rockford, IL Veterinary Sciences, U of Wisconsin Veterinary School, Madison, WI Dept of Pharmacology, U of Wisconsin Medical School, Madison, WI Dept of Pathology, UTMB-San Antonio, Texas 1996 Immunology Colloquia, UW-Madison/Promega, Madison, WI “Alzheimer’s Disease”, Brain Awareness Week, Neurosciences Training Program, UW-Madison Division of Lab Medicine, Dept of Pathology, U Wisconsin Medical School Neuroscience Colloquia, U Wisconsin-Madison 1997 “Alzheimer’s Disease”, Brain Awareness Week, Neurosciences Training Program, UW-Madison GI Division Research Conference, Dept of Medicine, UW- Madison Translational Research Colloquia, UW Medical School Dept of Pathology, Tulane University School of Medicine, NO, LA “Transfusion Medicine Update”, UW-Medical School CME 1998
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Dept of Molecular Biology, Message Pharmaceuticals, Aston, PA Dept of Pathology and Lab Medicine, Medical University of S. Carolina, Charleston, SC Dept of Pathology, U Wisconsin Medical School Wisconsin Association of Blood Banks, Milwaukee, WI Dept of Pathology, Lab Medicine and Immunology, U of Florida Medical School, Gainesville, FL 1999 Asthma Program, NIHLB, NIH, Bethesda, MD “CJD and Blood Transfusion”, St. Clare Hosp, Baraboo, WI 2000 Kiwanis Club of Madison, WI, “Alzheimer’s Disease” Dept of Medicine, UW Madison, “Massive Transfusion”
Division of Continuing Studies, UW- Madison, “Alzheimer’s Disease” Wisconsin Chapter, American Association of Blood Banks, “Apheresis” 2001 Medical Scientist Training Program, Spring Symposium, UW-Madison Dept of Pathology and Lab Medicine, “GM-CSF, Eosinophils and Asthma”, UW-Madison Ray Owens Immunology Symposium, “Posttranscriptional Gene regulation and Asthma”, UW-Madison Columbus Hospital, Columbus WI, “Creuztfeld-Jacob Disease”, CME 2002 Blood Center of Southeastern Wisconsin, Milwaukee, WI 2003 Waisman Center, UW-Madison 2004 American Red Cross, Badger Hawkeye Region Annual Meeting. Dept of Medicine, UW-Madison, Nephrology Grand Rounds 2005 Frontiers in Pharmacology, Dept of Pharmacology, UW-Madison
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2006 Dept of Medicine, UW-Madison, Nephrology Grand Rounds Immunology Colloquia, UW-Madison Institute on Aging, UW-Madison 2007 International Eosinophil Society, Snowbird, Utah Astellas Pharmaceuticals, Chicago IL Genzyme Pharmaceuticals, Boston, Mass Medical Scientist Training Program, UW-Madison Wisconsin Blood Bank Association, Milwaukee, WI 2008 AAAAI Annual Meeting, Philadelphia, PA. Banbury Meeting, Fragile X Syndrome, Cold Spring Harbor, NY. Department of Pathology, UAB, Birmingham, AL. National Fragile X Foundation Meeting, St. Louis, MO 2009 Department of Physiology, Michigan State University, Lansing, MI Institute of Molecular Medicine and Cell Research, Center for Biochemistry and Molecular Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany. International Eosinophil Society, Bruges, Belgium Department of Pathology and Lab Medicine, UW-Madison 10th International Conference on Alzheimers Drug Discovery, Jersey City, NJ 2010 Department of Pathology and Lab Medicine, UW-Madison American Red Cross, Badger-Hawkeye Region Immunology Training Program, Case Western Reserve U, Cleveland, OH
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Department of Pathology, Case Western Reserve U, Cleveland, OH Wisconsin Association of Blood Banks, Milwaukee, WI Simmons Cancer Center, UT Southwestern, Dallas, TX 2011 Alpha Eta Honorary Society, Commencement Address, UT Southwestern, Dallas, TX
Department of Pathology, UT Southwestern, Dallas, TX 2012
Recent Progress in Alzheimer’s Disease, Department of Neurology & Alzheimer’s Disease Center, UTSW 2013
International Symposium on Cyclophilins, Halle (Saale) Germany
2014 Thomas Jefferson University, PACB Grand Rounds, Department of Pathology, Anatomy & Cell Biology, Philadelphia, PA
2015
Department of Physiology, UTSW 2016
Center for Alzheimer’s and Neurodegenerative Diseases, UTSW 2017 Fujian University, Fuzhou, China Sun-Yat Sen University, Guangzhou, China 2018 Department of Pathology, Weill Cornell Medical School, NY, NY Milka Monkova Lecture, Department of Pathology, UTHSCSA, San Antonio, TX. Department of Neuroscience, Cleveland Clinic, Cleveland, OH Wei Jieping Medical Foundation, Zhongshan, China
