Jan 2009 by “N”
PHARMACIST1. Homeostasis as defined as ------ the body balance system2. In GLC, one of the phase is preferred ---------volatile (Gas) 3. Which if the following vit acting as a hormonea. Eb. B6c. D3d. A
4. TSH is secreted from a. hypothalamusb. anterior pituitaryc. posterior pituitaryd. adrenal medulla
5. All of the following hormones secreted from anterior pituitary EXCEPTa) FSHb) LHc) ACTHd) ADH
6. Which of the following does not secrets in duodenuma. Mucus cell secretionb. Pancreas secretionc. Liver secretiond. Gall bladder secretion
7. Define Angiogenosis------ Formation of new blood vessels
8. warfarin site of action is ------Liver9. Normally existed in blooda. prothrombinb. thrombinc. fibrin
10. The most effected cells with antineoplastic drugsa. neutrophilsb. lymphocytesc. platelets
11. First cells on the site of inflammation are a. basophilb. neutrophilc. platelets
12. DOC for coagulation in pregnancya. heparinb. warfarinc. ASA
13. A patient with cystitis should be counselleda. use diaphragm ( women who use the diaphragm are prone to inflammation)b. void after sexc. drink a lot of water
14. Uric acid production ↓ by which druga. allopurinolb. probenecidc. uricosuric agent
14. pencilline are small t 1/2 due to a. great protein binding b. active tubule secretionc. hydrolysis
15. Haemorrhoid patient can be advise to a. ↓ fiber dietb. Avoid prolong sitting timec. Avoid straining in toilet
16. poison IV which is not good advicea. loratadineb. epinephrine
17. sildenafil(PDE -5 inhibitor with nitrates do all EXCEPT
a. hypertensive crisisb. hypotension c. erectile disfunctioning
18. Prazosin do all EXCEPTa. Orthostatic hypotensionb. Hypertension crisis
19. Prazosin is a. α1 antagonistb. α 2 agonistc. β1 antagonistd. β2 agonist
20. The antidepressant work on epinephrine & dopamine, 5HT→
Dual action (SNRI’S, SNDRI’S)
21. Which antidepressant should be avoided when ↑ weight is undesirable
a. Mirtazapineb. Trazodonec. Bupropiond. Amitriptyline
22. What is the best treatment of uncomplicated diaper rash → ZnO
23. Poriasis is → Silvery white and red patches that form scales
24. Steven Johnso(
a. rashb. skin peeling
25. vertigo with meniers (infection of inner ear)disease -----
Gentamycin for vertigo, Low salt diet and Diuretics (Acetazolamide)
26. streptococcal meningitis is best treated with --------- Ampicillin + Gentamycin
27. All of them are used for HIV EXCEPTa. Efavirenzb. Trizivirc. Tenofovird. Acyclovir
28. Traponema pallidum----------- chancre(Ulceration in early stage of syphilis) & syphilis_
29. Which drug ↓ mortality in heart failurea. Enapri;b. Captoprilc. Digixond. Amlodipinee. Propranolol
30. In prinzmetalm agina all of them are good choice EXCEPTa. CCBb. BBsc. ACEId. Nitrates
31. Which is not a risk factor in Iron deficiency anaemiaa. Pregnancyb. Gastric refluxc. Peptic ulcerd. Haemorrhagee. Surgery
32. Which is not risk factor in hyper urecemia
a. hypertensionb. Obesityc. Pulmonary disease
Comments: Alcohol, atherosclerosis, diabetes, hyperlipidemia and hypertension, obesity, renal disease are among the risk factors of hyper urecemia
33. Define Ascitis ------ accumulation of fluid in peritoneal cavity
34. Evidence that DM exist , what blood glucose rate in fasting should be a. 5.2mmol/L – 7.1mmol/Lb. 7.1mmol/L -11.1mmol/Lc. 8.5mmol/L - 10.0mmol/Ld. 10.0mmol/L – 12.1mmol/L
35. which structure is best used in lipid parenteral injectionsa. CMCb. Cholesterolc. Phospholipids
36. Aluminium Acetate is used as ------burrow’s solution
37. All of them are important in plasmid EXCEPTa. DNAb. Bacteriac. Eukaryoticd. Ligasee. Restriction enzymes
38. Acetominophen prolonge used will effect ------ hepatoxicity
39. Defroxamine mechanism , site of action with Fe + ----- chelating
40. Aromatic and chealting ------------- penicillamine
41. mouth ulcer is the S.E of methotraxate treated by → folic acid
42. Major enzyme involved in the metabolism of drug → CYP 3A4
43. Structure of which enzymes with acetaminophen ------ Glutathione conjugation
44. Glutathione consists -------------- Cystein, Glycein , Glutamic acid
45. Which substance directly protects cell integrity ----------- Vit. E , Glutathione
46. Excipient that may cause diarrhea -------- Mg Stearate
47. Which subs may induce diarrhea----------mg stearate
48. Megaloblastic anemia is due to deficiency ------------ folic acid
49. Incorrect regarding Hcl EXCEPT
a. kill bacteriab. Kills C.difficle (anaerobic)
50. Fe absorption can be ↑ by Vit.C
51. Nystatin (antifungal for diaper rassh) ergosterol associated with --------------- cell lysis52. Phenols are most likely metabolised ------ Glucoronidation
53. Which is not a Phase II reaction ---a. sulfoxidationb. N-acetylation
54. Which of these condition antithyroid drug is used for a. Grave diseaseb. cretinismc. myxedema
55. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per dose-------------------- if 1 pack 5mg then 3 pack contain 15mg, ----------- Ans : 3
56. A physician in a unit dose hospital writes for Prednisone 15mg tid, each package contain 1 x 5mg tablets. How many package are needed per day--------------------- if 1 pack is 5mg then 3 pack contain 15mg and for 3 days , 3 x 3 = 9Ans, ie 3pack in the morning , 3 pack in the noon and 3 pack in the evening
57. Prolong use of which drug may cause thrombocytopenia------- ibuprofen adverse effect NOT good for heart patient
58. Which drug may cause GI problem--------- Indomethacin
59. Cox II inhibitor is least likely cause -------- GI problem
60. Tubular reabsorption of weak base ---- what is NOT factor a. PH of urineb. pka of drugc. rate flow of urined. metabolisme. lipid solubility
61. Define hypertrophy------ enlargement of organ OR Tissue
62. Gout patient which drug is NOT preferred-------------acetominophan (NSAID)
63. One with milk allergy is allergic to what-----a. proteinb. lactose
64. Which of the following is ARR--------
65. On a long flight what should be counsela. Don’t drink tap waterb. Don’t eat large mealsc. Dimenhydrinate is effective in motion sickness
66. Emesis resulted from Narcotic is due to a. Direct effect on GIb. Stimulation of CTZ
67. Which opioid receptors are involved in paina. meu
68. Chemistry of one of Ach analogue can inhibitor with enzyme------- Ach cholinesterase
69. structure of Purine analog
70. Esomeprazol & omeprazole relationship ----------------------- PPI’s
71. Cimetedine ---------------- not used in allergic reaction
72. Silver sulfasalazine ------what is in the structure that makes it not absorbable?
Azo Bond
73. What is substituted in penicillin that makes it long acting ------- amide group?
74. Cephalosporin structure---------------- CH2 -N I I CH2 C = O 75. SAR ( structure activity relationship) of ciprofloxacina. presence of F atomb. presence of CH2 group
also contain COOH group
76. nasal absorption what is wrong a. using of peptidesb. large surface increases systemic absorptionc. large volume need preservatives
77. Which is NOT a cranial bone
a. Frontalb. Ethmoidc. Occipitald. Sphenoide. Hyoid (Tongue bone)f. Maxial(face bone)
78. Which one of the following is a least emetogenic druga. cyclophosphamideb. doxirubicinec. tamoxifined. rosiglitazonee. bleomycin
79. Patient Not respond to drug what will you give
80. Urinary incontinency in women which is not effectivea. progesterone
b. Estrogen (also used)
c. oxybutin(Ist Line)d. impramine( in children)e. tolterodrine( Ist line)
81. Q about plan B82. About correct OCP way83. Regimen of plan B84. What is controlling the cerebral blood flowa. PCO2 ( Partial pressure of co2)
b. PO2
85. HCO3 is present in interstial fluid in higher conc ---------in plasma
86. Aminoglycoside are best to be taken in daily because → t 1/2 12 hours→ their MOA is unknownNote : post dose effect must be there
87.Clathromycin resemble with------------------Erthromycin
87. Drink a lot of water with a. sulfonamideb. alluporinal
88. Sufamethoxazole MOA---------- folate synthesis inhibitor
89. Cholesterol ------- chelate with which enzyme
a. aromatase
b. epoxidasec. hydroxilased.
90. Defination “DNA”
90. Correct sequence of DNA & RNA ↓ ↓ T U
91. The drug that produce LEAST hypokalemia ------ → spironolactone
92. Diarrhea in patient ---------------- due to Statins
93. Rhabdomyolysis or myopathy (muscle disease) is S.E of ---------------statins
94. Theophylline C.I with -------------------- Cimetedine
95. Drugs least affected by hepatic microsomal enzymes-------
a. Penicillinb. erythromycinc. ketoconazole
96. GABA MOA is ------------------------97. Whish one of the following is a essential amino acid
PTVTIMHALL
98. Primary protein is made up of amino acids linked by peptide bonds
99. Vit deficiency in smoker is----------------------- “C”
100. Dysopyramide MOA.......... Na ,< K
101. Status Epileptics treatment ------------------- IV Diazepam
102. Atropine ------------ophthalmic solution or suspension
103. hypertonic solution ---what is added to make it isotonica. waterb. Naclc. NaoHd. CH3
104. Metformin is C.I in all EXCEPT a. Renal failureb. Adjuvantc. Insulin & obese
Comment : Metformin is contraindicated in both renal and hepatic failure
105. rate limiting step in percutaneous absorption------ stratum corneaum
106. Structure of morphine what is important-----------P-Phenyl N-Alkyl moiety
Morphine Antagonist contains Ally Group
107. Rapid acting insulin , what is correct
Taken 15 min before meal
108. what is correct regarding human insulin subs by others a. dose adjustment should be done for regular insulin
109. What is not first line therapy for T.B
a. penicillinb. INH
110. Protein can be detected by
a. western Blotting
111. Asthma patient what is not useda. beta blockersb. bronchodilator
112. A terminally ill patient (liver disease) what is decreasea. clotting timeb. ASTc. ALTd. Albumine. Billirubin
113. What is true regarding COPDa. co morbidity with asthmab. linked significantly with cigarettesc. LABA & SABA is non –effectived. B-agonist is the same importance as in asthma
114. To reach CSS fast what characteristics of drug should be
t 1/2 & renal clearance and liver metabolism
115. Which of the following (monoclonal antibody) used in therapy of metastatic breast cancer
116. Herceptin (trastuzumab) is a. treatment of HER 2 –over expressing metastatic breast cancerb. Tumour necrosis factor alpha inhibitorc. Glycoprotein inhibitord. Interleukine. Interferon
\
117. ↓ ADH leads toa. Pyurea(pus in urine)b. thirstc. osmolarity?
Decreased osmolarity of plasma causes decrease release of ADH
Osmolarity is the measure of solute conc. Per litre.........ADH causes reabsorption of solute free water , hence the conc of solute increase in urine and decreases in plasma
118. DOC for pregnant in hypertensiona. methyldopa
119. DOC for pregnant in diabetesa. Insulin
120. Nicotine replace therapya. rotation of patchb. if sensitive to gum can use patches
121. All of them in type I DM EXCEPTa. Juvenile b. Obesityc. Keto acidosis
122. Which hepatitis can be chronic
B, C & D
123. treatment for hep “C” is a. interferon α
124. All of them are the S.E of clozapinea. agranulocytosis
125. Define lypholization----------- freez drug methods
126. P.O.S is ----------127. Best to asses inventory is ------------- turn over rate128. Negotiation between union and employer is a. bargainingb. debatec. argumentationd. arbitration
129. which is NOT important in vaccinationa. cleaning of handsb. cleaning of placec.
130. Abbreva (docosanol) is used for a. coughb. cold sore ( Topical Cream)c. decongestiond. allergye. rosacea
131. A patient with cystic acne ,what is the best treatment-------isotretinoin
132. Cholycystitis is ------------inflammation of bladder
133. premenopause with osteoprosis which is inappropriatea. Vit. Db. Estrogens
c. Raloxifen since it aggravates hot flushes so don’t start until menopause is established..................ONLY IN POST MENOPAUSE
d. Fosamax
135. if a drug is 150mg ---CSS is 19 , if 300mg CSS will be -----52
134. What is correct a. enzymes liver is saturatedb. albumin binding
135. what is saturated means
For drug induced Parkinson’s disease to treat Extra pyramidal symptoms
136. Ideal temp for suppositories is
a. 30Cb. 45 Cc. 60Cd. 15C
138. Cholestyramine ↓ which circulatory subs ------ All except Triglycerides139. Embolism Def------------ moving blood clot
140. Atherosclerosis Def ------------- ↓ blood flow in arteries due to deveopement of atherosclerotic plaques
141. Blood is transported to liver through ------------- portal vein
142. Vaccine of pneumococcal is required a. every yearb. every ten yearc. once a life
142. Tetanus vaccine needed every a. ten yearsb. every yearc. once a life
143. Diff between complicated and uncomplicated UTI can be recognized a. urgent need of urination b. turbid urine
144. Uncomplicated UTI sulfonc regimenis a. 1 Dayb. 3 days If Complicated then 10 DAYS Cotrimoxazolec. 10 daysd. 14 days
145. Turbohaler what is correcta. counselled for high dose drugb. sensitive to humidityc. one dose
146. Spacer used in turbohaler counsellinga. clean with wet tissueb. Not with water
147. Angle bwtween liquid and solid is described as a. Wet ability
148. Tonicity --------- what is wrong a. it can be measured by freezing point depression
Comments:
It is a colligative property
149. ↓ cortisone ,what disease --------------- Addison’s Disease150. Pilocarpine produce -----------------------------miosis151. Cycloplegia Definition ------------- pyralysis of eye muscles----ciliary muscles
caused by anticholinergics
152. Prophylatic therapy for endocarditis is required in all except a. previous exposed infectionb. substituted valvec. post M.I
153. One have sleep disorder you can advise all excepta. sleep time regularb. exercise before bedtimec. don’t sleep in the afternoon
154. Second application for anti lice shampoo is required because -----a. eggs leftb. new born leftc. not clear very well
155. DEET ------------------------------------------counselling
Avoid in eyes & mouth156. Topical therapy for alopecia-------Minoxidil
157. All of these required safe disposal EXCEPTa. needleb. syringec. lancetd. spatula
157. Abbreviation cc means----------- with food
158. OU means---------------------------------- both eyes159. ZnSO4 200mg displace with 50mg of coca butter base
160. In microcytic anaemia , what is wrong
a. reduce volume of cellb. increase serum ferritin coz it decreases
158. What include CBCa. Hematocritb. WBCc. RBC
159. Ca++ reabsorption occur in which part of nephrona. distal tubule\b. convulated tubulec. loop of henle
161. Inflammatory bowl disease --------------------crohn’s disease162. Peptic ulcer ---------------- h-pylori
163. Etiology Def----------causation
164. Large dose of antibiotic needed-----------
To overcome resistence
165. High dose from 50mg to 100mg
a. there will be ↑ in fraction of elimination drug / unit timeb. ↑ Vd
166. Diff between soft contact lense and gas rigidity lensa. less fragileb. high H2O content
167. Enzyme produce by bacteria ------ B- lactamase
168. Acid resistant penicillin is -----------cloxacillin it is also resistant to B-Lactamase
169. Which is a choice in therapy of -ve meningitis --------Penicillin G
170. Chemistry in structure of cortisone when C binds to O ----Hemiacetal
171. Precurser of vit D3 is --------- 7 dehydrocholestrol
172. Drug bound to ---acid Albumin
173. Drugs in O/W ---- partition coefficient ----- c of v = SD / X x 100
174. BMI = weight (in kg) / h ( in miter)
If a person weight is 60 kgAnd height is 6ft
1 Meter= 3.3 ftI ft = 12inch1 meter= 39.5 inch
BMI = 6ft x 12(inch) = 72 inch
180 / 100 = 1.8m
BMI = 60 / (1.8)2 = 60 / 3.24 = 18.51 Ans
Note : orlistat is only given when BMI is more than 30
175. Phase I ------ also called functional Group metabolism or Mixed function Oxidase Metabolism
176. Which is reverseable MAO-I -----meclobemide
177. Hemoglobin cannot carry O2 due to which reaction a. oxidationb. reductionc. 0d. 0
178. The plane that divide body into unequal left and right ----parasagital
179. Intra-thecal admin means ------------ In Spine
180. The particle of disperse phase have inherent stability, why? Becausea. small surface areb. high surface area
181. Levigating agent is ------- mineral oil
182. Zero order ---------- slope ---- k in C10 +10+10 +10 +10 zero order25+50+75+ half life
183. Absolut risk reduction is -------------ARR = EER --- CER
184. Competitive inhibitor-------------
185. What decrease in elderly -----------Body lean mass
186. Major difference between plasma and interstitial fluid
a. quantity of protein
187. 5 α reductase inhibitor ------finastride-----BPH
188. Monitoring of hypothyroidism ------ Serum TSH assay
189. Orlistat----------------------intestinal lipase inhibitor
190. Phenytoin S.E --------gingival hyperplasia
191. A drug designed as patch -
The shelf life t 1/2 is one year the researcher should do what is shelf life or t1/2 os over one year
192. Haploid is --------- No. of chromosomes of gemed , single set of chromosomes
Examples : sperm and ova
193. Which drug can not be use for chronic Spasticity ( multiple sclorisis)
a. Dantrolineb. Baclofen
c. Clonzepam
JANUARY 2009 (PART -2)
1. Angiogenesis means - Formation of blood vessels2. Hypertrophy means – Enlargement of cells by size rather
than increase in number of cell3. Cystitis means –bladder inflammation4. Sciatic nerve in all foot branch5. All branch of cerebral except Hyoid6. pOH of 0.1M NaOH find pH
pOH = -logOH pOH= -log0.1 = 1pW = pH + pOH pH = 14 – 1 = 13
7. Antithyroid used for gravies disease8. All cause anemia (bleeding) except GERD9. H.pylori associated with peptic ulcer.10. Which is not in duodenal lumen: - adrenal gland 11. DNA sequence is Adenine, Guanine, Cytosine,
Thiamine or except Uracil12. Active form of vit.D is 1,25-dihydroxycholecalciferol13. Iron undergo with defiroxamin – chelation reaction14. Iron cause microcytic anemia15. All are true about iron except- give for 12month16. Which contain epithelial cell all except – bile salts,
sweat, milk, saliva, hydrochloric acid17. OU means – both eye
18. Haploid is one set of chromosome19. P.O.S is point of sale20. Fluticasone which is correct – rinse mouth after use21. Use disposal bags for all except – razor blades22. SNRI is venalfexine23. Canada health cover all except - outpatient
prescription24. Major inhibitory neurotransmitter- GABA\25. Calculate gross margin in %
Gross M= sales – cost of good sales X 100 Sales
26. Calculate how many tablets required for family of 5people having malaria5X6= 30tablets
27. All correct about Leukotrine except 1) product of arachidonic acid not lipo-oxygenase 2) treatment of chronic
asthma 3) acute asthma 4)essential fatty acid (5) granulocyte cells (ans)
28. Restrictive endonuclease cleavage DNA at special site
29. Nystatin mechanism of action cell lysis or leakage of cells
30. Equilibrium between organic (oil) and water Ans partition coefficient
31. Calculate coefficient of variance given standard deviation and mean C.V. = Standard Deviation X 100 Means
32. Calculate ARR (Absolute Risk Reduction)33. Ca++ is absorbed from PTH from distal tubule34. Parental lipid emulsion need phospholipids
35. A person complains from the side effect of drug, patient told the doctor and doctor still give him the medication what pharmacist have to do talk to the doctor
36. Vitamin lack in smoker vitamin C37. Vitamin D3 is hormone
38. LH & FSH are secreted from anterior pituitary gland39. All are action of glutamine acid except
40. Proteins separated by western blotting41. Megaloblastic anaemia is due to deficiency of vit.
B12 and folic acid
42. Meningitis treated by ceftriaxone43. Drugs highly bound albumin44. Which highly bound to opoid (Delta) (enkepilin) 45. Which is responsible for muscle relaxing Ach with Nicotine
46. Indol is found in serotonin47. Paralysis of ciliary muscle is cycloplegia48. Alpha1 cause all except arteriodilation49. Embolism is clotting of blood50. Angina treated by all except diuretic51. CHF include all except 52. Abundant Ion in plasma HCO353. Class I antiarrythmic due Na sensitivity54. TSH from anterior pituitary gland55.