Jason Kovacic - CURRICULUM VITAE PERSONAL...

Jason C Kovacic, MD, PhD July, 2019 1

Jason Kovacic - CURRICULUM VITAE PERSONAL INFORMATION

Name: Jason Ciril Kovacic MD, PhD, FRACP, FACC, FSCAI, FAHA Associate Professor of Medicine, Icahn School of Medicine at Mount Sinai Address: 1 Gustave L. Levy Place, Box 1030 New York, NY, 10029 Telephone: +1 646.593.2552 Email: [email protected]

EDUCATION AND TRAINING

Education 01/1987 - 12/1994 University of Melbourne, Australia; MD 01/1991 - 06/1992 University of Melbourne, Australia; BMedSc 01/2004 - 06/2007 University of New South Wales, Australia; PhD 07/2007 - 06/2009 National Institutes of Health (Intramural Program, National Heart, Lung and

Blood Institute), Bethesda, USA; Postdoctoral Fellow

Postdoctoral Training Internships and Residencies

01/1996 - 12/1996 Intern, Prince of Wales Hospital, Sydney, Australia 01/1997 - 12/1998 Resident, Internal Medicine, Prince of Wales Hospital, Sydney, Australia

Research and Clinical Fellowships 01/1999 - 12/2002 Cardiology Fellow, St. Vincent’s Hospital, Sydney, Australia 01/2003 - 12/2003 Interventional Cardiology Fellow, St. Vincent’s Hospital, Sydney, Australia 07/2007 - 06/2009 Postdoctoral Fellow, National Institutes of Health (Intramural Program,

National Heart, Lung and Blood Institute), Bethesda, USA 07/2009 - 06/2010 Interventional Cardiology Fellow, Mount Sinai School of Medicine, New York,

USA LICENSURE AND CERTIFICATION

Medical License New York License, License number: 250218, Registration number: 6503587 New South Wales, Australia, Registration number: MPO - 322406

Board Certification (current) Australia

Fellow, Royal Australasian College of Physicians, MIN #16017

USA Internal Medicine, American Board of Internal Medicine (ABIM ID #364703) Cardiovascular Disease, American Board of Internal Medicine (ABIM ID #364703)


ACADEMIC APPOINTMENTS

01/1999 - 12/2002 Clinical Fellow in Cardiology, St. Vincent’s Hospital, Sydney, Australia 01/2003 - 12/2003 Fellow in Interventional Cardiology, St. Vincent’s Hospital, Sydney, Australia 01/2004 - 06/2007 Doctoral Fellow, Victor Chang Cardiac Research Institute, Sydney, Australia 07/2007 - 06/2009 Postdoctoral Fellow, National Institutes of Health (Intramural Program;

National Heart, Lung and Blood Institute, Translational Medicine Branch), Bethesda, USA

07/2009 - 06/2010 Fellow in Interventional Cardiology, Mount Sinai School of Medicine, New York, USA

07/2009 – 06/2012 Special Volunteer, National Institutes of Health (Intramural Program; National Heart, Lung and Blood Institute, Translational Medicine Branch), Bethesda, USA

07/2010 - 06/2011 Associate, Mount Sinai School of Medicine, New York, USA 07/2011 - 12/2014 Assistant Professor of Medicine, Icahn School of Medicine at Mount Sinai,

New York, USA 10/2013 - pres Graduate Faculty, Graduate School of Biomedical Sciences, Icahn School of

Medicine at Mount Sinai, New York, USA. 04/2014 - pres Affiliate Investigator, Stem Cells Australia 10/2014 - pres Adjunct Faculty, Rensselaer Polytechnic Institute, Troy, NY, USA

01/2015 - pres Associate Professor of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA

07/2015 - pres Associate Director of Interventional Structural Heart Disease Program, Mount Sinai Hospital, New York, USA

10/2017 - pres Director, Mount Sinai Cardiovascular Biorepository and ‘Omics Facility 05/2019 - pres Director, Cardiovascular Translational Science, Icahn School of Medicine at

Mount Sinai 05/2019 - pres Acting Director, Cardiovascular Research Center, Icahn School of Medicine at

Mount Sinai HOSPITAL APPOINTMENTS

01/1997 - 12/1999 Resident Physician, Prince of Wales Hospital, Sydney, Australia 01/2000 - 06/2007 Clinical Fellow, St. Vincent’s Hospital, Sydney, Australia 07/2009 - 06/2010 Clinical Fellow, Mount Sinai Hospital, New York, USA 07/2010 - pres Cardiologist, Mount Sinai Hospital, New York, USA

AWARDS AND HONORS

1986 Valedictorian, Caulfield Grammar School, Melbourne, Australia 1992 Academic Achievement Award, The Australian Institute of Sport, Canberra, Australia 1994 Honors graduate (3rd class), The University of Melbourne, Melbourne, Australia 2005 Australian Delegate to Lindau Nobel Prizewinners Meeting, Lake Constance,

Germany 2005 Plenary presentation, Haematology Society of Australia and New Zealand/Australian

and New Zealand Society of Blood Transfusion/Australasian Society of Thrombosis and Haemostasis annual scientific meeting, Sydney, Australia

2009 FARE award, National Institutes of Health 2010 Dedication and Achievement Award as a fellow in Interventional Cardiology, The

Zena and Michael A. Weiner Cardiovascular Institute and The Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai Medical Center


2011 Doris Duke Charitable Foundation Clinical Scientist Development Award Finalist 2013 “Emerging Leader”, Society for Cardiovascular Angiography and Interventions, and

American College of Cardiology 2015 “Elite Reviewer”, Journal of the American College of Cardiology 2015 Journal of the American College of Cardiology “Editor-in-Chief’s Top Picks from 2014”

(for: Michelis KC, Olin JW, Kadian-Dodov D, d’Escamard V, Kovacic JC. Coronary Artery Manifestations of Fibromuscular Dysplasia. J Am Coll Cardiol. 2014; 64(10): 1033-1046)

2017 Admission into Mount Sinai LEAD Academy (Leadership Emerging in Academic Departments)

2018 Cullman Family Award for Excellence in Physician Communication (for ranking in the top 1% nationally in provider communication by CMS’s CGCAHPS patient experience survey).

2018 Deans Healthcare System Team Science Award, Icahn School of Medicine at Mount Sinai (as PI of the DEFINE-FMD study)

MEMBERSHIPS OF PROFESSIONAL SOCIETIES

2004 - 2007 International Associate Member, American College of Cardiology 2005 - 2013 Member, American Heart Association 2004 - pres Member, Cardiac Society of Australia and New Zealand 2003 - pres Fellow, Royal Australasian College of Physicians 2008 - pres Fellow, American College of Cardiology 2011 - pres Fellow, Society for Cardiac Angiography and Interventions 2013 - pres Fellow, American Heart Association (BCVS council) 2018 - pres Member, International Society for Biological and Environmental Repositories (ISBER)

MAJOR COMMITTEE ASSIGNMENTS

National Institutes of Health (NIH) Study Sections and Committees 2011 NHLBI Program Project Grant Ad Hoc Review Committee member 2012 - 2017 NHLBI Cardiovascular Cell Therapy Research Network (CCTRN) Protocol Review

Committee member 06/2018 NIH Biomaterials and Biointerfaces (BMBI) ad hoc study section member 10/2018 NIH Vascular Cell and Molecular Biology (VCMB) ad hoc study section member 2019 - pres NIH Vascular Cell and Molecular Biology (VCMB) standing study section member

Professional Societies

2013-2015 Publications committee, Society for Cardiovascular Angiography and Interventions Meetings

2002 Organizing committee member, The World Congress of Cardiology, Interventional Workshop. Sydney, Australia

2005 Organizing committee member, Asia-Pacific Interventional Advances Conference, Newcastle, Australia

2008-2009 Organizing committee member, 3rd NHLBI Symposium on Cardiovascular Regenerative Medicine meeting, National Institutes of Health, Bethesda, MD, USA

2010-2011 Organizing committee member, 4th NHLBI Symposium on Cardiovascular Regenerative Medicine meeting, National Institutes of Health, Bethesda, MD, USA




2016 Co-Director, Complex Coronary, Valvular and Vascular Cases, Mount Sinai, New York, NY, USA




2018 Co-Director, New York Transcatheter Valves, New York, NY 2019 Co-Director, New York Transcatheter Valves, New York, NY 2019-2020 Scientific Advisory Board, International Academy of Cardiology, 24th World Congress

on Heart Disease, Boston, MA 2019-2020 Co-Organizing Chair, Frontiers in Cardiovascular Genetics, Diagnostics and Therapeutics meeting, Djurhamn, Sweden - June 2020.

Clinical Trials 2011 Member, Clinical Events Committee, Xience V USA Trial 2011 Member, Clinical Events Committee, Xience V DAPT Trial 2011 Member, Clinical Events Committee, PARIS Registry: Patterns of Non-adherence to

Antiplatelet Regimens In Stented Patients 2013 Member, Clinical Events Committee, Bravo II/III Study 2013 Chair, Clinical Events Committee, WIN TAVI Registry (Women’s INternational

Transcatheter Aortic Valve Implantation Registry) EDITORIAL POSITIONS

2013 - 2014 Circulation Research; Guest Editor 2014 - pres Journal of the American College of Cardiology; Section Editor - Basic and Clinical

Research 2014 - 2016 Vascular Medicine; Guest Editor 2015 - 2016 Hurst’s The Heart 14th edition; Assistant Editor 2017 – pres Vascular Medicine; Editorial Board Member

INVITED AD HOC MANUSCRIPT, ABSTRACT AND CHAPTER REVIEWER

2005 International Journal of Cardiology 2006 International Journal of Cardiology 2007 Heart Development 2nd edition. Edited by Harvey and Rosenthal 2008 Cell Stem Cell

International Journal of Cardiology American Heart Association - abstract review (Annual Scientific Sessions)

2009 Cellular and Molecular Life Sciences American Heart Journal

2010 International Journal of Cardiology Journal of Gerontology: Medical Sciences

2011 Circulation


Journal of Gerontology: Medical Sciences American College of Cardiology - abstract review (ACC-i2 meeting)

2012 Circulation PLoS One Journal of Interventional Cardiology International Journal of Cardiology 2013 Journal of Vascular Research Circulation

Clinical Cardiology Stem Cell Reviews and Reports Journal of Interventional Cardiology International Journal of Cardiology

American Heart Association – Scientific Statement review Transcatheter Cardiovascular Therapeutics (TCT) - abstract review (2013 meeting) JACC: Cardiovascular Imaging

PLoS One 2014 American Heart Association/American Col. of Cardiol. – Scientific Statement review Soc. for Cardiovasc. Angiography and Interventions – abstract review (2014 meeting) PLoS One Journal of the American College of Cardiology Interventional Cardiology American Journal of Cardiology

Transcatheter Cardiovascular Therapeutics (TCT) - abstract review (2014 meeting) International Journal of Cardiology Journal of Interventional Cardiology

2015 Journal of the American College of Cardiology PLoS One Drug Design, Development and Therapy

International Journal of Cardiology JACC: Cardiovascular Imaging Circulation Research Clinical Cardiology Journal of Interventional Cardiology American College of Cardiology - abstract review (Annual Scientific Sessions)

2016 Journal of the American College of Cardiology Soc. for Cardiovasc. Angiography and Interventions – abstract review (2016 meeting) Nature Communications PLoS One JACC Interventions Science Translational Medicine American College of Cardiology - abstract review (Annual Scientific Sessions) Vascular Medicine Circulation: Cardiovascular Genetics JACC: Cardiovascular Imaging

2017 Journal of the American College of Cardiology Nature Communications Soc. for Cardiovasc. Angiography and Interventions – abstract review (2017 meeting)

eLife Cell Research Vascular Medicine Science Heart JACC Basic to Translational Science


Arteriosclerosis, Thrombosis, and Vascular Biology American College of Cardiology - abstract review (Annual Scientific Sessions) Circulation Research

2018 Soc. for Cardiovasc. Angiography and Interventions – abstract review (2018 meeting) Vascular Medicine Circulation: Genomic and Precision Medicine Arteriosclerosis, Thrombosis, and Vascular Biology The Journal of Pathology Journal of the American College of Cardiology Stem Cell Reports The FASEB journal Circulation Research International Journal of Cardiology American College of Cardiology - abstract review (Annual Scientific Sessions)

2019 Journal of the American College of Cardiology Circulation Research JACC: Basic to Translational Science JACC: Case Reports

INVITED AD HOC GRANT REVIEWER

2007 National Heart Foundation of Australia 2008 National Heart Foundation of Australia 2011 NHLBI Program Project Grant Review (see above)

Medical Research Council (United Kingdom) 2014 Diabetes Australia

Austrian Science Fund 2015 Wellcome Trust (United Kingdom) Centre for Vascular Regeneration; Edinburgh-Kings-Bristol program (UK) 2016 French National Research Agency 2018 United States – Israel Binational Science Foundation 2018 NIH BMBI and VCMB study sections (see above)

GRANT SUPPORT

Current Research Support

1R01HL130423 PI: Jason Kovacic Award Period: 1/25/2016 – 1/24/2021 Awarding Body: NIH/NHLBI Title: Toward Therapeutic Manipulation of Endothelial to Mesenchymal Transition This proposal seeks to leverage several novel discoveries made by our team to define the core biologic mechanisms of EndMT in atherosclerosis and cardiovascular disease, to understand how we can manipulate EndMT to promote healing after vascular grafting procedures, and ultimately to develop novel therapeutic strategies for cardiovascular disease. R01HL135093 PI: Jason Kovacic (MPI with Dr. Ken Fish) Award Period: 01/20/2017 – 12/31/2020 Awarding Body: NIH/NHLBI Title: Therapeutic Mechanisms of Cardiac Progenitors in Ischemic Cardiomyopathy We will examine the roles cardiac progenitor cells (CPCs) in heart failure as a foundation for understanding their endogenous regenerative potential. Our program uses innovative delivery


vectors and state of the art genomics technologies to examine CPC biology, reparative potential and impacts after myocardial function. T32HL007824 PI: Jason Kovacic (MPI with Dr. Bruce Gelb) Award Period: 01/07/1995 – 31/07/2023 Awarding Body: NIH/NHLBI Title: Training program in molecular and cellular cardiology This training program housed at the Icahn School of Medicine at Mount Sinai emphasizes not only training post-doctoral scientists in molecular and cellular cardiology, but also on fostering their development as independent researchers. Mount Sinai Heart Fibromuscular Dysplasia Research Program Co-PIs: Kovacic and Olin Award Period: 3/31/2016 - 3/30/2020 Awarding Body: Anonymous Philanthropic Donor Fibromuscular Dysplasia (FMD) is a non-inflammatory vascular disease of unknown etiology. This program will undertake an extensive clinical (PI: Olin) and molecular (PI: Kovacic) characterization of this disease. Using skin biopsies to generate patient-specific cell lines, we will establish the cellular and genetic profile of fibroblasts and other vascular cells from FMD patients and matched healthy controls. Our aim is to identify activated pathways and genes, and to ultimately elucidate the underlying cause of this condition. R01HL071021 (Fayad) Award Period: 05/01/2015-04/30/2020 PI: Zahi Fayad (Kovacic = Co-I) Awarding Body: NIH/NHLBI Direct Costs: $309,288 Title: MR/PET Imaging of coronary atherosclerosis The goal is to develop improvements in imaging techniques for a novel, combined MRI and PET imaging system. Such advances will significantly impact understanding and diagnosis of atherosclerosis in the coronary arteries. R01 HL135878 PI: Zahi Fayad (Kovacic = Co-I) Award period: 4/1/2017 - 3/31/2021 Awarding body: NIH/NHLBI Title: Ga68 DOTATATE PET imaging of plaque inflammation The goal is to thoroughly validate plaque imaging with 68Ga-DOTATATE PET, a macrophage-specific tracer, to allow for the better quantification of plaque inflammation, and more successful stratification of patients at high-risk for cardio- and cerebrovascular events. R01HL139865 PI: Ron Do (Kovacic = Co-I) Award period: 2/1/2018 – 1/31/2022 Awarding body: NIH/NHLBI Title: Resolving causal influences among correlated risk biomarkers for coronary artery disease Epidemiological studies have shown correlations among numerous biomarkers and risk for coronary artery disease (CAD); however, it's unknown whether many of these biomarkers represent causal processes for CAD. In this proposal, we will use genetic analysis to infer causal relationships between cardiometabolic traits, metabolites and clinical phenotypes for subclinical CAD disease outcomes. Completion of this proposal has the potential to reveal new biomarker targets for the development of new drug therapeutics for the prevention and treatment of CAD. 1R01HL143221 PI: Neomi Shah (Kovacic = Co-I) Award period: 07/01/18 - 06/30/23 Awarding body: NIH /NHLBI Title: "Imaging the Atherosclerosis Cascade in Sleep Apnea"


Our study will non-invasively quantify the entire atherosclerosis cascade including endothelial dysfunction, vascular stiffness, vascular inflammation, plaque composition and total plaque burden in patients with sleep apnea using state-of-the-art vascular imaging. Our study will provide significant mechanistic insight regarding the role sleep apnea plays in the progression of atherosclerosis and regarding the anti-atherosclerotic actions of continuous positive airway pressure therapy. Our study will identify patients at high risk for progression of atherosclerosis and those who have the greatest anti-atherosclerotic actions of sleep apnea treatment. Industry studies Role: Co-I (Total effort for all studies = 3% FTE) Awarding bodies: varies, but include Medtronic, Daiichi Sankyo, Astra Zeneca. Dr. Kovacic is a Co-Investigator on several industry funded clinical trials run through the catheterization laboratory of Mount Sinai – see summary table below. He serves in a supporting role that is largely is encompassed within his routine clinical duties. For example, a normal routine clinical duty of Dr. Kovacic is implanting cardiac valves (Transcatheter Aortic Valve Replacement – TAVR). TAVR is routine in patients deemed to be at intermediate or higher risk for surgery. A current area of clinical research is if TAVR is beneficial for patients at low surgical risk. However, for Dr. Kovacic performing the TAVR in a low risk study patient the study procedure is essentially identical to a regular clinical implant in a patient of higher risk. Neither Dr. Kovacic nor his research program receives any funding from these studies. Study Sponsor

Title Role of Dr Kovacic

Direct Costs

Medtronic Low Risk Bicuspid Study Co-I Variable depending on patient enrolment

Mayo Clinic The MITRAL TRIAL: Mitral Implantation of Transcatheter Valves

Co-I Variable depending on patient enrolment

Daiichi Sankyo Edoxaban versus standard of care and their effects on clinical outcomes in patients having undergone transcatheter aortic valve implantation – in atrial fibrillation edoxaban


Medtronic Transcatheter Aortic Valve Replacement With The Medtronic Transcatheter Aortic Valve Replacement System In Patients at Low Risk for Surgical Aortic Valve Replacement


Medtronic Medtronic CoreValve Evolut-R Clinical Study Co-I Variable depending on patient enrolment

Medtronic Medtronic CoreValve Continued Access Study Co-I Variable depending on patient enrolment

Thoratec Corporation

HeartMate PHP Coronary Interventions in High Risk Patients Using a Novel Percutaneous Left Ventricular Support Device (SHIELD II)

Co-I (not currently participating)

Variable depending on patient enrolment


Completed Research Support

LEDUCQ Transatlantic Network of Excellence PI: Jason Kovacic Award Period: 10/01/2013 – 12/31/2018 Awarding body: Foundation LEDUCQ (Transatlantic Networks of Excellence Program) Title: Cellular and molecular targets to promote therapeutic cardiac regeneration The rationale for this network lies in the acute need for defining the mechanisms regulating and ultimately limiting regenerative responses of the adult heart. Unraveling the complex and poorly understood processes mediating the age-dependent decline in cardiovascular stem cell efficacy and regenerative capacity is a core objective of this network. A suite of mechanistic studies will lead to the identification of targets that can be modulated to boost the endogenous regenerative potential of the adult mammalian heart, including the use of small molecules that stimulate the mobilization of endogenous CSCs or transiently activate de-differentiation. 14SFRN20490315 (Overall Program); 14SFRN20840000 (Project 3) Program PI: Fuster; Project 3 PI: Schadt (Kovacic: Co-I Project 3) Award Period: 7/1/2014 – 06/30/2018 Awarding Body: American Heart Association Title: Family-Based Approach to the Prevention of Cardiovascular Disease in a Minority Community Integrating Systems-Biology This American Heart Association Strategically Focused Prevention Research Network aims at improving the cardiovascular risk profile of 600 preschool aged children (Project 1) and 1000 of their direct caregivers (Project 2) by a healthy lifestyle intervention. In Project 3 we will use DNA from the children and both DNA and inflammatory cell-derived RNA from caregivers to identify network models and predictors of primary prevention outcomes using genetic, genomic and molecular data from children and adults before and after lifestyle intervention. We will also seek novel therapeutic and diagnostic targets by leveraging these network models of early atherothrombotic disease. 5K08HL111330 PI: Jason Kovacic Award Period: 12/1/2011 – 11/30/2016 Awarding Body: NIH/NHLBI Title: Cellular and molecular mechanisms of endothelial repair and atherosclerosis The major goals of this proposal are to characterize the contribution of endothelial cells to arterial homeostasis, arterial repair and atherosclerosis. Using unique mouse models this proposal will define the function of endothelial cells in these processes and also investigate the ability of endothelial cells to change their phenotype to become smooth muscle cells, fibroblasts or other cells that drive atherosclerosis. ISSCRES0141 PI: Jason Kovacic Award Period: 04/29/2013 – 6/20/2016 Awarding Body: AstraZeneca Title: YELLOW II Study - Reduction in Coronary Yellow Plaque, Lipids and Vascular Inflammation by Aggressive Lipid Lowering This investigator initiated clinical study will assess the in vivo regression of atherosclerotic yellow plaque content and changes in plaque morphology after high-dose statin therapy by utilizing diffuse reflectance near-infrared spectroscopy (NIRS) and optical coherence tomography (OCT) in diseased coronary arteries of ischemic heart disease patients presenting for coronary angiography. Concurrently, lipid trafficking, reverse cholesterol transport and the inflammatory macrophage phenotype will be assessed in response to changes in patient lipid profiles. High-dose statin therapy (rosuvastatin 40mg daily) will be administered to all subjects (n = 80), with baseline measurements being compared to those at final follow-up after 8-12 weeks of therapy for each subject.


Rensselaer – Mount Sinai Collaborative Research Project PI: Kovacic Award Period: 3/1/14 – 7/1/15 Awarding Body: Rensselaer – Mount Sinai Title: In situ generation of tissue-engineered vascular conduits using vascular progenitor cells This project aims to generate robust and biologically efficacious tissue engineered vascular grafts (TEVG). By combining the unique attributes of the Kovacic and Hahn labs, our novel vascular progenitor cells, and unique biomaterials with both high compliance and strength, we have designed a forward looking project geared toward producing clinically efficacious vascular conduits. Post-doctoral fellowship received under T32 training award Training program in molecular and cellular cardiology 5T32HL007824-15 PI: Bruce D. Gelb NIH/NHLBI Period received: 7/1/2010 – 6/30/2011 (Overall period of T32 award: 7/1/95 - 6/30/13) The major goal of this award is to provide training in molecular and cellular cardiology to pre-doctoral students and post-doctoral fellows. Post-doctoral Fellowship Award Period: 07/2007 – 06/2009 NIH/NHLBI (Intramural program – Boehm/Nabel Lab) Role of RANTES in regulating acute vascular injury and arterial wound repair The goal was to characterize acute vascular injury and wound repair programs, particularly with respect to inflammation, its signaling pathways, and the role of endothelial and smooth muscle cells.

Medical Postgraduate Scholarship Award Period: 01/2004 – 06/2007 National Health and Medical Res. Council of Aust. Clinical angiogenesis strategies in refractory ischemic heart disease


TRAINEES

Name

Claire Abramoff (nee Tolbert) Rohit Gupta Solene Evrard Jennifer Li

Kenji Fujitani Aya Kitabayashi Katherine Michelis

Valentina d'Escamard Dong Kwon Yang Laura Lecce Maria Paola Santini Jonathan Lee

Level of Trainee

Pre-doctoral Pre-doctoral Pre-doctoral and post-doc

Pre-doctoral (medical student) Pre-doctoral (medical student) Post-doc Post-doc (medical resident) Post-doc Post-doc Post-doc Post-doc Pre-doctoral (Bachelor of Medical

Role in Training & Dates of Training

Co-mentor 2007 - 2009 Co-mentor 2007 - 2009 Mentor/supervisor: 2010 – 2013 Mentor/supervisor: 2011 – 2013 Mentor/supervisor: 2012 – 2014

Mentor/supervisor: 2012 – 2018 Mentor/supervisor: 2012 – 2018 Mentor/supervisor: 2013 – pres Mentor/supervisor: 2013 – 2016 Mentor/supervisor: 2014 – 2018 Mentor/supervisor: 2014 – pres Mentor/supervisor: 2014

Training Venue

NIH Intramural Program NIH Intramural Program Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai

Kovacic Lab, Mount Sinai

Kovacic Lab, Mount Sinai Kovacic Lab and Mount Sinai Heart Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai

Trainees’ Current Status/Employment

Assistant Professor, University of Chicago, Department of Medicine Cardiologist, Rochester Regional Health, Rochester, NY Assistant Professor, Rangueil Hospital, Toulouse, France Vascular Surgery Resident, Beth Israel Deaconess Medical Center, Boston, MA (received MSTAR award for work in Kovacic Lab) Resident, Stony Brook University Hospital, Long Island, NY (received MSTAR award for work in Kovacic lab) Instructor, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY Advanced Heart Failure Fellow at UT Southwestern Medical Center Senior Research Associate, Kovacic Lab Research Assistant Professor, Chungbuk National University, Chungbuk, Korea. Educational Developer, University of New South Wales, Sydney, Australia. Post-doc in Kovacic Lab (will soon become Instructor at Mount Sinai) Resident, Alfred Hospital, Melbourne, Australia (received Bachelor of Medical Science


Nirupama Chandel Yang Xu Ana Sofia Cruz Solbes

Science candidate) Post-doc Masters and then PhD student Post-doc

Mentor/supervisor: 2016 – pres Mentor/supervisor: 2016 – pres Mentor/supervisor: 2018 – pres

Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai Kovacic Lab, Mount Sinai

Degree at Monash University, Melbourne, Australia for studies in Kovacic Lab) Post-doc in Kovacic Lab PhD student in Kovacic Lab Post-doc in Kovacic Lab

INVITED LECTURES / CHAIRMANSHIPS / PRESENTATIONS

2001 - 2006 Invited Speaker, University of New South Wales final year medical student common campus teaching program, Annual Lecture. Lecture title: “Cardiology On Call – What an Intern Needs to Know About Cardiac Emergencies.”

2003 Chairman, Fellows and Registrars Interventional Cardiology Workshop. Melbourne, Australia.

2003 Invited Speaker, NSW Stem Cell Workshop/Satellite and National Stem Cell Conference. Sydney, Australia. Lecture title: “Endothelial progenitor cells for refractory ischaemic heart disease.”

2005 Invited Speaker, Snowmass Interventional Cardiology Meeting, Snowmass, CO, USA. Lecture title: “The use of Granulocyte-Colony Stimulating Factor and an intracoronary CD133+ cell infusion in patients with refractory IHD.”

2005 Invited Speaker, NSW Cardiac Retreat, Blue Mountains, NSW, Australia. Lecture title: “Cardiac and Endothelial Progenitor Cells – new paradigms in cardiovascular medicine.”

2006 Invited Speaker, ASEANZ Cardiovascular and Lipid forum, Melbourne, Australia. Lecture title: “Stem Cells and cardiovascular disease – emerging new paradigms.”

2006 Invited Speaker, Cardiac Club of Australasia meeting, Sydney, Australia. Lecture title: “The use of Granulocyte-Colony Stimulating Factor and an intracoronary CD133+ cell infusion in patients with refractory IHD.”

2006 Invited Speaker, New England Area Health Service educational seminar, Armidale, NSW, Australia. Lecture title: “Stem Cells and cardiovascular disease – emerging new paradigms.”

2006 Invited Speaker, Asia Pacific Interventional Advances Conference, Sydney, Australia. Lecture title: “Growth and Mobilization Factors.”

2007 Invited Speaker, National Heart Foundation, Cardiology VII Conference, Brisbane, Australia. Lecture title: “Cardiovascular disease and stem cell-based repair.”

2010 Invited Speaker, American College of Cardiology Annual Meeting, Atlanta, GA, USA. Lecture title: “Coronary Perforation During PCI for Chronic Total Occlusion.”

2010 Invited Speaker, Live Symposium of Complex Coronary and Vascular Cases, New York, NY, USA. Lecture title: “Coronary Perforation During PCI for Chronic Total Occlusion.”

2011 Invited Speaker, British Cardiovascular Society Annual Conference, Manchester, UK. Lecture title: “Endothelial-mesenchymal transition: an endogenous injury response”


2011 Chairman, 4th NHLBI Symposium on Cardiovascular Regenerative Medicine meeting, Bethesda, MD. Session VII: “Clinical Trials Update/Roundtable: Are we Ready for the Next Generation of Stem Cell-related Therapy”

2012 Invited Speaker, Korean Society of Cardiology Annual Spring Congress, Busan, South Korea. Lecture title: “Recent Advances in the Understanding of Plaque Formation, Progression and Vulnerability”

2012 Invited Speaker, St. Mary’s Hospital Cardiology Grand Rounds, Seoul, South Korea. Lecture title: “Endothelial-mesenchymal transition: an endogenous injury response”

2012 Invited Speaker, American Heart Association Annual Scientific Sessions, Los Angeles, CA. Lecture title: “Endothelial Repair Mechanisms: An Interventional Perspective”

2012 Moderator, American Heart Association Annual Scientific Sessions, Los Angeles, CA. Session: “Hot Topics in Catheter-Based Coronary Interventions: Experimental and New Technology”

May 2013 Invited Speaker, CNIC-Spanish Society of Cardiology-Mount Sinai Cardiovascular Exchange, New York, NY. “Cell Therapy for the Treatment of Heart Failure”

Sept 2013 Chairman, 5th NHLBI Symposium on Cardiovascular Regenerative Medicine, Bethesda, MD. Session: “Clinical Applications”

Oct 2013 Invited Speaker, Echo New York – Multimodality Imaging New York, New York, NY. Lecture title: “When is Intracoronary Imaging Indicated?”

Mar 2014 Invited Speaker, American College of Cardiology Annual Scientific Sessions, Washington, DC. Lecture title: “Tandem Heart: Is There Still a Role?”

Mar 2014 Moderator, American College of Cardiology Annual Scientific Sessions, Washington, DC. Session: “Basic Mechanisms of Atherosclerosis”

May 2014 Invited Speaker, University of Glasgow, Institute of Cardiovascular & Medical Sciences, Glasgow, Scotland. Lecture title: “Endothelial to Mesenchymal Transition: From Cardiovascular Development to Disease”

May 2014 Invited Speaker, Golden Jubilee National Hospital, Glasgow, Scotland. Lecture title: “Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: time to DEFINE the cause!”

May 2014 Invited Speaker, First International Fibromuscular Dysplasia Symposium, Cleveland Clinic Foundation, Cleveland, OH. Lecture title: “The DEFINE FMD Study – defining the molecular and cellular basis of FMD using patient-derived fibroblasts”

May 2014 Invited Speaker, Society for Cardiac Angiography and Interventions Scientific Sessions, Las Vegas, NV. Lecture title: “Left Main Intervention – Difficult Delivery”

June 2014 Invited Speaker, Coronary Atherosclerosis Research Symposium, New York, NY. Lecture title: “Endothelial to Mesenchymal Transition and Beyond”

Sept 2014 Invited Speaker, Transcatheter Cardiovascular Therapeutics Meeting, Washington, DC. Lecture title: “Becoming a successful researcher: How to secure funding and ramp-up your publications”

Sept 2014 Invited Speaker, Transcatheter Cardiovascular Therapeutics Meeting, Washington, DC. Lecture title: “Valvular Heart Disease: Aortic Valvuloplasty and TAVR”

Mar 2015 Moderator, American College of Cardiology Annual Scientific Sessions, San Diego, CA. Session: “Diabetes: New Concepts and TACTful Debates”

Mar 2015 Invited Speaker, American College of Cardiology Annual Scientific Sessions, San Diego, CA. Lecture title: “The Integration of Genomics into Computerized Systems Biology: An Evolution in the Understanding of CV Disease by the Clinician”

Sept 2015 Invited Speaker, 6th NHLBI Symposium on Cardiovascular Regenerative Medicine, Bethesda, MD. Lecture title: “Atherosclerosis and Vascular Disease: Inflammation, Genetics, and Cell Biology”

Sept 2015 Moderator, 6th NHLBI Symposium on Cardiovascular Regenerative Medicine, Bethesda, MD. Session: “Cardiac Remodeling and Inflammation”


Dec 2015 Invited Speaker, American College of Cardiology New York Cardiovascular Symposium, New York, NY. Lecture title: “ACS: Recent and Evolving Aspects, Definitions and Diagnostics, Acquired and Genetic Factors, Ischemic and Reperfusion Injury”

Dec 2015 Invited Speaker, Washington University School of Medicine, St. Louis, MO. Lecture title: “Leveraging Systems Genetics to Understand Fibromuscular Dysplasia and Coronary Artery Disease”

June 2016 Invited Speaker, National Institutes of Health, Bethesda, MD. Lecture title: “EndMT, CAD and FMD – intersecting vascular biology and disease states”

June 2016 Invited Speaker, Complex Coronary, Valvular and Vascular Cases, Mount Sinai, New York, NY, USA. Lecture title: “LV support during PCI”

Aug 2016 Invited speaker, International Symposium of Complex Cardiovascular Medicine, Medellin, Colombia. Lecture titles: “Indications for TAVR and the Role of Risk Assessment”, and “Minimally Invasive Devices for Cardiac Failure and LV support”

Sept 2016 Invited speaker, TAVR: A Multi-Disciplinary, Multi-Modality Heart Team Approach, New York, NY, USA. Lecture titles: “History of TAVR”, “Low Coronary Height and TAVR”, and “Coronary Evaluation and Treatment Timing”

Nov 2016 Invited speaker, American Heart Association Annual Scientific Sessions, New Orleans, LA. Lecture title: “The High-Risk STEMI Patient. Elderly, CKD, Diabetics.”

Feb 2017 Invited speaker, Icahn School of Medicine at Mount Sinai, Department of Medicine, Medical Grand Rounds. Lecture title: “Defining the cause of fibromuscular dysplasia; and redefining our understanding of spontaneous arterial dissection.”

May 2017 Invited Speaker, Society for Cardiac Angiography and Interventions Scientific Sessions, New Orleans, LA. Lecture title: “Atherectomy for calcified lesions – Rotational Atherectomy”

May 2017 Panelist, Society for Cardiac Angiography and Interventions Scientific Sessions, New Orleans, LA. Session: “Coronary imaging and physiology”

May 2017 Invited Speaker, Second International Fibromuscular Dysplasia (FMD) Research Network and Spontaneous Coronary Artery Dissection (SCAD) Symposium, Cleveland Clinic Foundation, Cleveland, OH. Lecture title: “Mount Sinai DEFINE- FMD Study Update”

June 2017 Invited Speaker, Gordon Research Conference – Atherosclerosis, Sunday River, Newry, ME. Lecture title: “Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Correlates with Instability"

June 2017 Invited Speaker, Fondation Leducq Understanding Coronary Artery Disease Genes Network Annual Meeting, Paris, France. Lecture title: “Defining the cause of the "rare" vascular disease fibromuscular dysplasia using systems genetics and leveraging CAD genetics datasets.”

Sept 2017 Invited Speaker, Vanderbilt University, Division of Cardiovascular Medicine, Nashville, TN. Lecture title: “Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Correlates with Plaque Instability.”

Sept 2017 Moderator, 7th NHLBI Symposium on Cardiovascular Regenerative Medicine, Bethesda, MD. Session: “Translational Cardiovascular Stem Cell Biology II”

Oct 2017 Invited Speaker, Albert Einstein College of Medicine (Montefiore), New York, NY. Lecture title: “PCI in Patients with Aortic Stenosis: New Paradigms for Treatment?”

Oct 2017 Invited Speaker, Mount Sinai Advanced Heart Disease Symposium, New York Academy of Medicine, New York, NY. Lecture title: “Hybrid PET-MRI imaging for Cardiac Sarcoid – A Game-Changer for Diagnosis and Management”

Feb 2018 Invited Speaker, New York University, Vascular Biology Program and the Center for the Prevention of Cardiovascular Disease, New York, NY. Lecture title: “Endothelial to Mesenchymal Transition Contributes to Plaque Formation and Plaque Instability.”


Feb 2018 Invited Speaker, International Symposium Revisiting Fibromuscular Dysplasia & Related Vascular Diseases, Belgian Royal Academy of Medicine, Brussels, Belgium. Lecture title: “What can we learn from the fibroblast? The DEFINE study”

Mar 2018 Panelist, American College of Cardiology 67th Annual Scientific Sessions, Orlando, FL. Session: “Make Structural Heart Great Again.”

Mar 2018 Moderator, American College of Cardiology 67th Annual Scientific Sessions, Orlando, FL. Session: “Improving TAVR Through Imaging: Seeing Is Believing!”

Nov 2018 Invited Speaker, American College of Cardiology – How to Become a Cardiovascular Investigator, Washington, DC. Lecture title: “Bridging and Funding Opportunities for Young Investigators”

Mar 2019 Invited Speaker, Conoscere e Curare il Cuore 2019; XXXVI Congresso di Cardiologia, Florence, Italy. Lecture title: “Macrophages and CV Disease”

Mar 2019 Invited Speaker, American College of Cardiology Annual Scientific Sessions, New Orleans, LA. Lecture title: “Spontaneous Coronary Artery Dissection - Post Discharge Care: It’s Not Over Yet‐ What Do I Tell my Patient?”

Apr 2019 Invited Speaker, CARDIO Excellence Meeting, New York, NY. Lecture title: “Percutaneous Treatment of Aortic Valve Disease”

Apr 2019 Moderator, Third European Microcirculation and Vascular Biology Conference, Maastricht, The Netherlands. Session: “Vascular Cell Heterogeneity”

Apr 2019 Invited Speaker, Third European Microcirculation and Vascular Biology Conference, Maastricht, The Netherlands. Lecture title: “Endothelial to Mesenchymal Transition and Endothelial Cell Plasticity”

May 2019 Invited Speaker, Montreal Heart Institute, Université de Montréal, Canada. Lecture title: “Endothelial to Mesenchymal Transition in Cardiovascular Disease.”


BIBLIOGRAPHY Theses (1) Kovacic JC. Blood Viscosity in Elite Athletes. Thesis submitted to the University of Melbourne for

the degree of Bachelor of Medical Science. Accepted December, 1991. (2) Kovacic JC. The use of granulocyte-colony stimulating factor and an intracoronary CD133+ cell

infusion in patients with chronic refractory ischaemic heart disease. Thesis submitted to the University of New South Wales for the degree of Doctor of Philosophy (PhD). Accepted May 2007.

Peer Reviewed Publications (1) Kovacic JC, Telford R. Review: Blood Viscosity in Athletes. Excel 1992; 8: 73-84. (2) Hahn AG, Telford RD, Tumilty DMcA, McBride ME, Campbell DP, Kovacic JC, Batschi R,

Thompson PA. Effect of Supplementary Hypoxic Training on Physiological Characteristics and Ergometer Performance of Elite Rowers. Excel 1992; 8: 127-138.

(3) Telford RD, Kovacic JC, Skinner SL, Hobbs JB, Cunningham RB. Resting Whole Blood Viscosity of Elite Rowers Is Related to Performance. Eur J Appl. Physiol. 1994; 68: 470-476.

(4) Kovacic JC, Muller DWM. Hypertrophic cardiomyopathy: state-of-the-art review, with focus on the management of outflow obstruction. Intern Med J. 2003; 33: 521-529.

(5) Kovacic JC, Kuchar DL. Brugada pattern electrocardiographic changes associated with profound electrolyte disturbance. Pacing Clin Electrophysiol. 2004; 27:1020-1023.

(6) Kovacic JC, Horton MDA, Campbell TJ, Wilson SH. Left atrial hematoma complicating inferior myocardial infarction. J Am Soc Echocardiogr. 2004; 17: 1201-1203.

(7) Kovacic JC, Roy PR, Baron DW, Gunalingam B, Muller DWM. Percutaneous carotid artery stenting: a strategy in evolution. Intern Med J. 2005; 35:143-150.

(8) Kovacic JC, Muller DWM, Harvey R, Graham RM. An update on the use of stem cells for cardiac disease. Intern Med J. 2005; 35: 348-356.

(9) Kovacic JC, Martin A, Carey D, Wand H, Mallon PWG, Feneley MP, Emery S, Cooper DA, Carr A. Influence of rosiglitazone on flow-mediated dilation and other markers of cardiovascular risk in HIV-infected patients with lipoatrophy. Antiviral Therapy 2005; 10: 135-143.

(10) Kovacic JC, Roy PR, Baron DW, Muller DWM. Staged Carotid Artery Stenting and Coronary Artery Bypass Graft Surgery: initial results from a single center. Catheter Cardiovasc Interv. 2006; 67: 142-148.

(11) Mallon PWG, Miller J, Kovacic JC, Kent-Hughes J, Norris R, Samaras K, Feneley MP, Cooper DA, Carr A. Effect of pravastain on body composition and markers of cardiovascular disease in HIV-infected men – a randomized, placebo-controlled study. AIDS 2006; 20: 1003-1010.

(12) Kovacic JC, Macdonald P, Freund J, Rasko JEJ, Allan R, Fernandes VB, Ma D, Moore J, Graham RM. Profound thrombocytopenia related to G-CSF. Am J Hematol. 2007; 82: 229-230.

(13) Kovacic JC, Muller DWM, Graham RM. Actions and therapeutic potential of G-CSF and GM-CSF in cardiovascular disease. J Mol Cell Cardiol. 2007; 42: 19-33.

(14) Kovacic JC, Moore J, Herbert A, Ma D, Boehm M, Graham RM. Endothelial Progenitor Cells, Angioblasts and Angiogenesis – old terms reconsidered from a current perspective. Trends in Cardiovasc Med. 2008; 18: 45-51.

(15) Olive M, Mellad JA, Beltran LE, Ma M, Cimato T, Noguchi AC, San H, Childs R, Kovacic JC, Boehm M. p21Cip1 modulates arterial wound repair through the SDF-1/CXCR4 axis. J Clin Invest. 2008; 118: 2050-61.


(16) Kovacic JC, Macdonald P, Feneley MP, Muller DWM, Freund J, Dodds A, Milliken S, Tao H, Itescu S, Moore J, Ma D, Graham RM. Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor, and an intracoronary CD133+ cell infusion in patients with chronic refractory ischemic heart disease: the GAIN I trial. Am Heart J. 2008; 156: 954-63.

(17) Kovacic JC, Boehm M. Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology. Stem Cell Res. 2008; 2: 2-15.

(18) Wragg A, Mellad JA, Beltran LE, Konoplyannikov M, San H, Boozer S, Deans RJ, Mathur A, Lederman RJ, Kovacic JC, Boehm M. VEGFR1/ CXCR4 positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1 dependent mechanism. J Mol Med. 2008; 86:1221-32.

(19) Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G, St. Hilaire C, Boehm M. STAT3-dependent acute RANTES production in vascular smooth muscle cells modulates inflammation following arterial injury. J Clin Invest. 2010; 120: 303-14.

(20) Ma M, Ding S, Lundqvist A, San H, Fang F, Konoplyannikov M, Berry C, Beltran LE, Chen G, Kovacic JC, Boehm M. MHC-I expression on ESC-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells. 2010; 28: 1465-1475.

(21) Iwasaki H, Kovacic JC, Olive M, Beers JK, Yoshimoto T, Crook MF, Tonelli LH, Nabel EG. Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation. Circ Res. 2010; 107: 992-1001.

(22) Kovacic JC, Khanna D, Kaplish D, Karajgikar R, Sharma SK, Kini A. Safety and Efficacy of Alcohol Septal Ablation in Patients with Symptomatic Concentric Left Ventricular Hypertrophy and Outflow Tract Obstruction. J Invasive Cardiol. 2010; 22: 586-591.

(23) Rubboli A, Kovacic JC, Mehran R, Lip GYH. Coronary stent Implantation in patients committed to long-term oral anticoagulation: successfully navigating the treatment options. Chest 2011; 139: 981-987.

(24) Kovacic JC, Moreno P, Hachinski V, Nabel EG, Fuster V. Cellular senescence, vascular disease and aging. Part 1 of a 2-part review: advances at the molecular and cellular level. Circulation 2011; 123: 1650-1660.

(25) Kovacic JC, Moreno P, Nabel EG, Hachinski V, Fuster V. Cellular senescence, vascular disease and aging. Part 2 of a 2-part review: clinical vascular disease in the elderly. Circulation 2011; 123: 1900-1910.

(26) Kovacic JC, Sharma SK, Kini AS. Bilateral Coronary Ostial Stenoses Post-Bentall Procedure Causing Hemodynamic Collapse and Requiring Mechanical Assist Device Placement: Successful Intervention Using the Szabo Technique. Catheter Cardiovasc Interv. 2012: 79: 801-804.

(27) Baber U, Kovacic JC, Kini AS, Sharma SK, Dangas G, Mehran R. How Serious a Problem is Bleeding in Patients with Acute Coronary Syndromes? Current Cardiology Report 2011; 13: 312-319.

(28) Kovacic JC, Fuster V. From treating complex coronary artery disease to promoting cardiovascular health: therapeutic transitions and challenges, 2010-2020. Clin Pharmacol Ther. 2011; 90: 509-518.

(29) Baber U, Mehran R, Sharma SK, Brar S, Yu J, Suh JW, Kim HS, Park SJ, Kastrati A, de Waha A, Krishnan P, Moreno P, Sweeny J, Kim MC, Suleman J, Pyo R, Wiley J, Kovacic J, Kini AS, Dangas G. Impact of the Everolimus-Eluting Drug Eluting Stent on Stent Thrombosis: A Meta-Analysis of 13 Randomized Trials involving 17,101 Patients. J Am Coll Cardiol. 2011; 58: 1569-77.

(30) Kovacic JC, Lee P, Baber U, Karajgikar R, Evrard SM, Moreno P, Mehran R, Fuster V, Dangas G, Sharma S, Kini A. Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions. Atherosclerosis 2012; 211: 176-82.

(31) Kovacic JC, Mercader N, Torres T, Boehm M, Fuster V. Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition: From Cardiovascular Development to Disease. Circulation 2012; 125: 1795-1808.

(32) Kovacic JC, Mehran R, Karajgikar R, Suleman J, Kim MC, Krishnan P, Dangas G, Sharma SK, Kini A. Female Gender and Clinical Outcomes After Coronary Interventions: Results From a Large Registry. Catheter Cardiovasc Interv. 2012; 80: 514-521.


(33) Chih S, Macdonald PS, McCrohon JA, Ma D, Moore J, Feneley MP, Law M, Kovacic JC, Graham RM. Granulocyte-Colony Stimulating Factor in Angina Patients to Stimulate Neovascularization (GAIN II) Trial: A randomized placebo-controlled crossover study. Heart 2012; 98: 282-90.

(34) Chirumamilla AP, Maehara A, Mintz GS, Mehran R, MD, Kanwal S, Weisz G, Hassanin A, Hakim D, Guo N, Baber U, Pyo R, Moses JW, Fahy M, Kovacic JC, Dangas GD. High Platelet Reactivity on Clopidogrel Therapy Correlates With Increased Coronary Atherosclerosis and Calcification: A Volumetric Intravascular Ultrasound Study. J Am Coll Cardiol Img. 2012; 5: 540-549.

(35) Evrard S, d’Audigier C, Mauge L, Israël-Biet D, Guerin CL, Bieche I, Kovacic JC, Fischer AM, Gaussem P, Smadja DM. Profibrotic cytokine TGF-β1 increases endothelial progenitor cell angiogenic properties. J Thromb Haemost. 2012; 10: 670-679.

(36) Kovacic JC, Castellano JM, Fuster V. Cardiovascular Defense Challenges at the Basic, Clinical and Population Levels. Ann. N.Y. Acad. Sci. 2012; 1254: 1-6.

(37) Kovacic JC, Castellano JM, Fuster V. The Links Between Complex Coronary Disease, Cerebrovascular Disease and Degenerative Brain Disease. Ann. N.Y. Acad. Sci. 2012; 1254: 99-105.

(38) Castellano JM, Kovacic JC, Sanz J, Fuster V. Are We Ignoring the Dilated Thoracic Aorta? Ann. N.Y. Acad. Sci. 2012; 1254: 164–174.

(39) Chinitz JS, Castellano JM, Kovacic JC, Fuster V. Atrial Fibrillation, Stroke and Quality of Life. Ann. N.Y. Acad. Sci. 2012; 1254: 140-150.

(40) Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Saebo K, Tsimikas S, Witztum J, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. Increased Expression of Oxidation-Specific Epitopes and Apoptosis are Haptoglobin Genotype Dependent: Implications for Plaque Progression in Human Atherosclerosis. J Am Coll Cardiol. 2012; 60: 112-119.

(41) Kovacic JC, Lee P, Karajgikar R, Baber U, Narechania B, Suleman J, Moreno PR, Sharma SK, Kini AS. Safety of temporary and permanent suspension of anti-platelet therapy after drug eluting stent implantation in contemporary ‘real-world’ practice. J Interv Cardiol. 2012; 25: 482-92.

(42) Kovacic JC and Fuster V. Atherosclerotic risk factors, vascular cognitive impairment, and Alzheimer disease. Mt Sinai J Med. 2012; 79: 664-73.

(43) Sharma AB, Kovacic JC, Kini AS. Percutaneous Left Ventricular Assist Devices. Interv Cardiol Clin. 2012; 1(4): 609-622.

(44) Kovacic JC, Nguyen, H, Karajgikar R, Sharma SK, Kini A. The Impella Recover 2.5 and TandemHeart Ventricular Assist Devices are Safe and Associated with Equivalent Clinical Outcomes in Patients Undergoing High-Risk Percutaneous Coronary Intervention. Catheter Cardiovasc Interv. 2013; 82(1): E28-37.

(45) Cubeddu RJ, Palacios IF, Blankenship JC, Horvath SA, Xu K, Kovacic JC, Dangas GD, Witzenbichler B, Guagliumi G, Kornowski R, Dudek D, Stone GW, Mehran R. Outcome of Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention During On- Versus Off-hours (A Harmonizing Outcomes With RevasculariZatiON and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Trial Substudy). Am J Cardiol. 2013; 111: 946-954.

(46) Kini AS, Baber U, Kovacic JC, Limaye A, Ali ZA, Sweeny J, Maehara A, Mehran R, Dangas G, Mintz GS, Fuster V, Narula J, Sharma SK, Moreno PR. Changes in Plaque Lipid Content after Short-Term, Intensive versus Standard Statin Therapy: The YELLOW Trial. J Am Coll Cardiol. 2013; 62: 21-29.

(47) Baber U, Bander J, Karajgikar R, Yadav K, Hadi A, Theodoropolous K, Gukathasan N, Roy S, Sayeneni S, Scott S, Kovacic JC, Yu J, Sartori S, Mehran R, Uribarri J, Badimon J, Muntner P, Moreno P, Kini AS, Sharma SK. Combined and Independent Impact of Diabetes Mellitus and Chronic Kidney Disease on Residual Platelet Reactivity. Thromb Haemost. 2013; 110: 118-23.

(48) Kovacic JC, Sharma AB, Roy S, Li JR, Narayan R, Kim DB, Sharma SK, Kini AS. GuideLiner mother-and-child guide catheter extension: a simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions. J Interv Cardiol. 2013; 26: 343-350.


(49) Kini A, Yu J, Cohen MG, Mehran R, Baber U, Sartori S, Vlachojannis GJ, Kovacic JC, Pyo R, O'Neill B, Singh V, Jacobs E, Poludasu S, Moreno P, Kim MC, Krishnan P, Sharma SK, Dangas GD. Effect of bivalirudin on aortic valve intervention outcomes study: a two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty. EuroIntervention. 2014; 10(3): 312-9.

(50) Wood CW, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT. Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis. Arterioscler Thromb Vasc Biol. 2013; 33: 1861-1871.

(51) Kovacic JC, Limaye AM, Sartori S, Lee P, Patel R, Chandela S, Trost B, Roy S, Harari R, Narechania B, Karajgikar R, Kim MC, Krishnan P, Moreno P, Baber U, Mehran R, Dangas G, Kini AS, Sharma SK. Comparison of six risk scores in patients with triple vessel coronary artery disease undergoing PCI: competing factors influence mortality, myocardial infarction and target lesion revascularization. Catheter Cardiovasc Interv. 2013; 82: 855-868.

(52) Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma’ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a Hemogenic Program in Mouse Fibroblasts. Cell Stem Cell. 2013; 13: 205-218.

(53) Ali ZA, Roleder T, Narula J, Mohanty BD, Baber U, Kovacic JC, Mintz GS, Otsuka F, Pan S, Virmani R, Sharma SK, Moreno P, Kini AS. Increased Thin-Cap Neoatheroma and Periprocedural Myocardial Infarction in Drug-Eluting Stent Restenosis: Multimodality Intravascular Imaging of Drug-Eluting and Bare-Metal Stents. Circ Cardiovasc Interv. 2013; 6: 507-517.

(54) Yang W, Kovacic JC, Cromwell C, Grosskreutz C, Mascarenhas J. Myocardial Infarction in a Young Man Receiving Chemotherapy for Acute Lymphoblastic Leukemia. Clin Adv Hematol Oncol. 2013; 11: 672–675.

(55) Kovacic JC, Castellano JM, Farkouh ME, Fuster V. The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis. Endocrinol Metab Clin North Am. 2014; 43: 41-57.

(56) Kovacic JC, Mehran R, Sweeny J, Li JR, Moreno P, Baber U, Krishnan P, Badimon JJ, Hulot JS, Kini A, Sharma SK. Clustering of acute and subacute stent thrombosis related to the introduction of generic clopidogrel. J Cardiovasc Pharmacol Ther. 2014; 19(2): 201-8.

(57) Roleder T, Kovacic JC, Ali Z, Sharma R, Cristea E, Moreno P, Sharma SK, Narula J, Kini AS. Combined NIRS and IVUS imaging detects vulnerable plaque using a single catheter system: a head-to-head comparison with OCT. EuroIntervention. 2014; 10(3): 303-11.

(58) Lipskaia L, Bobe R, Chen J, Turnbull IC, Lopez JJ, Merlet E, Jeong D, Karakikes I, Ross AS, Liang L, Mougenot N, Atassi F, Lompré AM, Kovacic JC, Kranias E, Hajjar RJ, Hadri L. Synergistic role of Protein Phosphatase Inhibitor 1 and SERCA2a in the acquisition of the Contractile Phenotype of Arterial Smooth Muscle Cells. Circulation. 2014; 129(7): 773-85.

(59) O’Neill B, Singh V, Kini A, Mehran R, Jacobs E, Knopf D, Alfonso CE, Martinez CA, Martinezclark P, O’Neill W, Heldman AW, Yu J, Baber U, Kovacic JC, Dangas G, Sharma S, Sartori S, Cohen MG. The Use of Vascular Closure Devices and Impact on Major Bleeding and Net Adverse Clinical Events (NACE) in Balloon Aortic Valvuloplasty: A Sub-Analysis of the BRAVO study. Catheter Cardiovasc Interv. 2014; 83(1): 148-53.

(60) Dangas GD, Maehara A, Evrard SM, Sartori S, Li JR, Chirumamilla AP, Kitabaysahi A, Gukathasan N, Hassanin A, Baber U, Fahy M, Fuster V, Mintz GS, Kovacic JC. Coronary artery calcification is inversely related to body morphology in patients with significant coronary artery disease: a 3-dimensional intravascular ultrasound study. Eur Heart J Cardiovasc Imaging. 2014; 15(2): 201-9.

(61) Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T. Effect of Bortezomib on the Efficacy of AAV9.SERCA2a Treatment to Preserve Cardiac Function in a Rat Pressure-Overload Model of Heart Failure. Gene Ther. 2014; 21(4): 379-86.

(62) Hulot JS, Stillitano F, Salem JE, Kovacic JC, Fuster V, Hajjar RJ. Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2014; 5(1): 1.

(63) Tomey MI, Narula J, Kovacic JC. Year in Review: Advances in Understanding of Plaque Composition and Treatment Options. J Am Coll Cardiol. 2014; 63: 1604-1616.


(64) Cooley C, Nevado J, Mellad J, Yang D, St. Hilaire C, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M. TGF-β signaling mediates endothelial to mesenchymal transition (EndMT) during vein graft remodeling. Sci Transl Med. 2014; 6(227): 227ra34.

(65) Kherada NI, Sartori S, Tomey MI, Mennuni MG, Meelu OA, Roy S, Mohanty BD, Baber U, Pyo R, Kovacic JC, Sweeny J, Moreno P, Krishnan P, Dangas GD, Mehran R, Sharma SK, Kini AS. Dedicated two-stent technique in complex bifurcation percutaneous coronary intervention with use of everolimus-eluting stents: The EES-bifurcation study. Int Jnl Cardiol. 2014; 174: 13-17.

(66) Michelis KC, Boehm M, Kovacic JC. New vessel formation in the context of cardiomyocyte regeneration – the role and importance of an adequate perfusing vasculature. Stem Cell Res. 2014; 13: 666-682.

(67) Garcia-Garcia HM, Jang IK, Serruys PW, Kovacic JC, Narula J, Fayad ZA. Imaging Plaques to Predict and Better Manage Patients with Acute Coronary Events. Circ Res. 2014; 114(12): 1904-17

(68) Fuster V and Kovacic JC. Acute Coronary Syndromes: Pathology, Diagnosis, Genetics, Prevention and Treatment – A Compendium Review. Circ Res. 2014; 114(12): 1847-51.

(69) Michelis KC, Olin JW, Kadian-Dodov D, d’Escamard V, Kovacic JC. Coronary Artery Manifestations of Fibromuscular Dysplasia. J Am Coll Cardiol. 2014; 64(10): 1033-1046.

(70) Giannarelli C, Alique M, Rodriguez DT, Yang DK, Jeong D, Calcagno C, Hutter R, Millon A, Kovacic JC, Weber T, Faries P, Soff GA, Fayad ZA, Hajjar RJ, Fuster V, Badimon JJ. Alternatively Spliced Tissue Factor Promotes Plaque Angiogenesis via the Activation of HIF-1α and VEGF signaling. Circulation. 2014; 130(15): 1274-86.

(71) Meelu OA, Tomey MI, Sartori S, Kherada N, Mennuni MG, Theodoropoulos KN, Sayeneni S, Baber U, Pyo RT, Kovacic JC, Moreno P, Krishnan P, Mehran R, Dangas GD, Kini AS, Sharma SK. Comparison of provisional 1-stent and 2-stent strategies in diabetic patients with true bifurcation lesions: the EES Bifurcation study. J Invasive Cardiol. 2014; 26(12): 619-23.

(72) Dohi T, Maehara A, Moreno PR, Baber U, Kovacic JC, Limaye AM, Ali ZA, Sweeny JM, Mehran R, Dangas GD, Xu K, Sharma SK, Mintz GS, Kini AS. The relationship among extent of lipid-rich plaque, lesion characteristics, and plaque progression/regression in patients with coronary artery disease: a serial near-infrared spectroscopy and intravascular ultrasound study. Eur Heart J Cardiovasc Imaging. 2015;16(1): 81-7.

(73) Kovacic JC, Kini A, Banerjee S, Dangas G, Massaro J, Mehran R, Popma J, O’Neill WW, Sharma SK. Patients with 3-vessel Coronary Artery Disease and Impaired Ventricular Function undergoing PCI with Impella 2.5 Hemodynamic Support Have Improved 90 Day Outcomes Compared to Intra-Aortic Balloon Pump: A Sub-Study of The PROTECT II Trial. J Interv Cardiol. 2015; 28: 32-40.

(74) Björkegren JLM, Kovacic JC, Dudley JT, Schadt EE. Genome-wide significant loci—how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders. J Am Coll Cardiol. 2015; 65: 830-845.

(75) Kini AS, Motoyama S, Vengrenyuk Y, Feig JE, Pena J, Baber U, Bhat AM, Moreno P, Kovacic JC, Narula J, Sharma SK. Multimodality intravascular imaging to predict periprocedural myocardial infarction during percutaneous coronary intervention. JACC Cardiovasc Interv. 2015; 8: 937-945.

(76) Sengupta PP, Wiley BM, Basnet S, Rajamanickman A, Kovacic JC, Fischer GW, Kini AS, Sharma SK. Transthoracic Echocardiography Guidance for TAVR Under Monitored Anesthesia Care. JACC Cardiovasc Imaging. 2015; 8(3): 379-80.

(77) Senguttuvan NB, Ellozy S, Tejani F, Kovacic JC, Kini AS, Sharma SK, Dangas GD. TAVR Through Heavily Calcified Aorta Following Atheroma Retrieval With the "Elevator" Technique. J Invasive Cardiol. 2015; 27(10): E216-9.

(78) Christodoulidis G, Yu J, Kini A, Dangas GD, Baber U, Melissa A, Sartori S, Theodoropoulos K, Bhat A, Kovacic JC, Moreno P, Krishnan P, Mehran R, Sharma S. Gender-specific outcomes after balloon aortic valvuloplasty: Inhospital and long-term outcomes. Am Heart J. 2015;170(1): 180-6.

(79) Vedanthan R, Bansilal S, Soto AV, Kovacic JC, Latina J, Jaslow R, Santana M, Gorga E, Kasarskis A, Hajjar R, Schadt EE, Björkegren JL, Fayad ZA, Fuster V. Family-Based Approaches to Cardiovascular Health Promotion. J Am Coll Cardiol. 2016; 67(14): 1725-37.


(80) Wiley B, Kovacic JC, Basnet S, Makoto A, Kini A, Sharma S, Sengupta P. Intraprocedural Transcatheter Aortic Valve Replacement (TAVR) Annulus Sizing Using Three-Dimensional Transesophageal Echocardiology And “The Turnaround Rule”. JACC Cardiovasc Imaging. 2016; 9(2): 213-5.

(81) Talukdar HA, Asl HF, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Björkegren JLM. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Systems. 2016; 2(3): 196-208.

(82) Jeong D, Lee MA, Li Y, Yang DK, Kho C, Oh JG, Hong G, Lee A, Song MH, LaRocca TJ, Chen J, Liang L, Mitsuyama S, D'Escamard V, Kovacic JC, Kwak TH, Hajjar RJ, Park WJ. Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis. J Am Coll Cardiol. 2016; 67(13): 1556-68.

(83) Santini MP, Forte E, Harvey RP, Kovacic JC. Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development. 2016; 143(8): 1242-1258.

(84) Abgral R, Dweck MR, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Padilla M, Miller M, Lala A, Sanz J, Narula J, Fuster V, Contreras J, Kovacic JC, Fayad ZA. Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease. JACC Cardiovasc Imaging. 2017; 10(5): 594-597.

(85) Kini AS, Vengrenyuk Y, Pena J, Yoshimura T, Panwar SR, Motoyama S, Kezbor S, Hasan CM, Palkhiwala S, Kovacic JC, Moreno P, Baber U, Mehran R, Narula J, Sharma SK. Plaque Morphology Predictors of Side Branch Occlusion after Provisional Stenting in Coronary Bifurcation Lesion: Results of Optical Coherence Tomography Bifurcation Study (ORBID). Catheter Cardiovasc Interv. 2017; 89(2): 259-268.

(86) Theodoropoulos K, Mennuni MG, Dangas GD, Meelu OA, Bansilal S, Baber U, Sartori S, Kovacic JC, Moreno PR, Sharma SK, Mehran R, Kini AS. Resistant In-Stent Restenosis in the Drug Eluting Stent Era. Catheter Cardiovasc Interv. 2016; 88(5): 777-785.

(87) Mosley GE, Beckerman W, Kovacic JC, Kini AS, Sharma SK, Tadros RO. Management of complete iliofemoral artery avulsion with a hybrid technique. J Vasc Surg Cases. 2016; 2: 37-39.

(88) Evrard SM*, Lecce L*, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d’Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Kovacic JC. Endothelial-To-Mesenchymal Transition Is Common In Advanced Atherosclerotic Lesions And Is Associated With Plaque Instability. Nat Commun. 2016 Jun 24;7:11853. doi: 10.1038/ncomms11853. *Equal contribution.

(89) Franzén O,* Ermel R,* Cohain A,* Akers NK, Di Narzo A, Talukdar HA, Asl HF, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Gianarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JLM. Cardiometabolic Risk Loci Share Downstream Cis- and Trans-Gene Regulation Across Tissues and Diseases: The Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task (STARNET) Study. Science. 2016; 353(6301): 827-30. *Equal contribution.

(90) Kiando SR, Tucker NR, Castro-Vega LJ, Katz A, D’Escamard V, Tréard C, Fraher D, Albuisson J, Kadian-Dodov D, Ye Z, Austin E, Yang ML, Hunker K, Barlassina C, Cusi D, Galan P, Empana JP, Jouven X, Gimenez-Roqueplo AP, Bruneval P, Kim ESH, Olin JW, Gornik HL, Azizi M, Plouin PF, Ellinor PT, Kullo IJ, Milan DJ, Ganesh SK, Boutouyrie P, Kovacic JC, Jeunemaitre X, Bouatia-Naji N. PHACTR1 Is A Genetic Susceptibility Locus For Fibromuscular Dysplasia; Supporting Its Complex Genetic Pattern of Inheritance. PLoS Genet. 2016; 12(10): e1006367.

(91) Kini AS, Vengrenyuk Y, Shameer K, Maehara A, Purushothaman M, Yoshimura T, Matsumura M, Aquino M, Haider N, Johnson KW, Readhead B, Kidd BA, Feig JE, Krishnan P, Sweeny J, Milind M, Moreno P, Mehran R, Kovacic JC, Baber U, Dudley J, Narula J, Sharma S. Intracoronary Imaging, Cholesterol Efflux, and Transcriptomes after Intensive Statin Treatment: The YELLOW II study. J Am Coll Cardiol. 2017; 69(6): 628-640.

(92) Krishnamoorthy P, Vengrenyuk Y, Ueda H, Yoshimura T, Pena J, Motoyama S, Baber U, Hasan C, Kesanakurthy S, Sweeny JM, Sharma SK, Narula J, Kovacic JC, Kini AS. Three Dimensional Volumetric Assessment of Coronary Artery Calcification in Patients with stable Coronary Artery Disease by OCT. EuroIntervention. 2017; 13(3): 312-319.


(93) Johnson KW, Shameer K, Glicksberg BS, Readhead B, Sengupta PP, Björkegren JLM, Kovacic JC, Dudley JT. Enabling Precision Cardiology through Disease Networks and Systems Pharmacotherapy. JACC Basic to Translational Science. 2017; 2(3): 311-327.

(94) Krishnan P, Tarricone A, Purushothaman KR, Purushothaman M, Vasquez M, Kovacic JC, Baber U, Kapur V, Gujja K, Kini A, Sharma S. An Algorithm for the Use of Embolic Protection During Atherectomy for Femoral Popliteal Lesions. JACC Cardiovasc Interv. 2017; 10(4): 403-410.

(95) Pena J, Vengrenyuk Y, Kezbor S, Yoshimura T, Kovacic JC, Sharma SK, Baber U, Kini AS, Narula J, Moreno PR. Increased Lipid Length, Macrophage Infiltration, and Neovascularization in Coronary Atheroma from Patients with Chronic Kidney Disease. JACC Cardiovasc Imaging. 2017; 10: 1524-1526.

(96) Farhan S, Baber U, Aquino M, Vogel B, Chandrasekhar J, Faggioni M, Giustino G, Kautzky-Willer A, Sweeny J, Shah S, Vijay P, Barman N, Moreno P, Kovacic J, Dangas G, Kini A, Mehran R, Sharma SK. Impact Of Diabetes Mellitus On Ischemic Events In Men And Women After Percutaneous Coronary Intervention. Am J Cardiol. 2017; 119(8): 1166-1172.

(97) Robson PM, Dweck MR, Trivieri MG, Abgral R, Karakatsanis NA, Contreras J, Gidwani U, Narula JP, Fuster V, Kovacic JC, Fayad ZA. Coronary Artery PET/MR Imaging: Feasibility, Limitations, and Solutions. JACC Cardiovasc Imaging. 2017; 10(10 Pt A): 1103-1112.

(98) Bansilal S, Vedanthan R, Kovacic JC, Soto AV, Latina J, Björkegren JLM, Jaslow R, Santana M, Sartori S, Giannarelli C, Mani V, Hajjar R, Schadt E, Kasarskis A, Fayad ZA, Fuster V. Rationale and Design of Family-Based Approach in a Minority Community Integrating Systems-Biology for Promotion of Health (FAMILIA). Am Heart J. 2017; 187: 170-81.

(99) Sack MN, Fyhrquist FY, Saijonmaa OJ, Fuster V, Kovacic JC. Basic Biology of Oxidative Stress and the Cardiovascular System. J Am Coll Cardiol. 2017; 70(2): 196-211.

(100) Münzel T, Camici GC, Maack C, Bonetti NR, Fuster V, Kovacic JC. Impact of oxidative stress on the heart and vasculature. J Am Coll Cardiol. 2017; 70(2): 212-229.

(101) Niemann B, Rohrbach S, Miller MR, Newby DE, Fuster V, Kovacic JC. Oxidative stress and cardiovascular risk factors: obesity, diabetes, smoking and pollution. J Am Coll Cardiol. 2017; 70(2): 230-251.

(102) Dweck MR, Abgral R, Trivieri MG, Robson PM, Karakatsanis N, Mani V, Palmisano A, Miller M, Lala A, Chang HL, Sanz J, Contreras J, Narula J, Fuster V, Padilla M, Fayad ZA, Kovacic JC. Hybrid MR/PET Imaging with FDG to Diagnose Active Cardiac Sarcoidosis. JACC Cardiovasc Imaging. 2018; 11: 94–107.

(103) Copeland-Halperin RS, Baber U, Aquino M, Rajamanickam A, Roy S, Hasan C, Barman N, Kovacic JC, Moreno P, Krishnan P, Sweeny JM, Mehran R, Dangas G, Kini AS, Sharma SK. Prevalence, Correlates, and Impact of Coronary Calcification on Adverse Events Following PCI with Newer-Generation DES: Findings from a Large Multi-Ethnic Registry. Catheter Cardiovasc Interv. 2018; 91(5): 859-866.

(104) Watanabe S, Fish K, Kovacic JC, Bikou B, Leonardson L, Nomoto K, Aguero J, Kapur NK, Hajjar RJ, Ishikawa K. LV Unloading using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure. J Am Heart Assoc. 2018; 7(6): pii: e006462.

(105) Franzén O, Ermel R, Sukhavasi K, Jain R, Jain A, Betsholtz C, Giannarelli C, Kovacic JC, Ruusalepp A, Skogsberg J, Hao K, Schadt EE, Björkegren JLM. Global analysis of A-to-I RNA editing reveals association with common disease variants. PeerJ. 2018; 6: e4466.

(106) Sherifi I, Omar AMS, Varghese M, Weiner M, Anyanwu A, Kovacic JC, Sharma S, Kini A, Sengupta P. Comparison of transesophageal and transthoracic echocardiography under moderate sedation for guiding transcatheter aortic valve replacement. Echo Res Pract. 2018 May 9. pii: ERP-17-0080. doi: 10.1530/ERP-17-0080. [Epub ahead of print]

(107) Michelis KC, Nomura-Kitabayashi A, Lecce L, Franzén O, Koplev S, Xu Y, Santini MP, D’Escamard V, Lee JTL, Fuster V, Hajjar R, Reddy R, Chikwe J, Stelzer P, Filsoufi F, Stewart A, Anyanwu A, Björkegren JLM, Kovacic JC. CD90 Identifies adventitial mesenchymal progenitor cells in adult human medium- and large-sized arteries. Stem Cell Reports. 2018; 11: 242-57.


(108) Khan AA, Kovacic JC, Engstrom K, Stewart A, Anyanwu A, Basnet S, Aquino M, Baber U, Garcia L, Gidwani U, Dangas G, Kini A, Sharma S. Comparison of Transaortic And Subclavian Approaches for Transcatheter Aortic Valve Replacement In Patients With No Transfemoral Access Options. Structural Heart. 2018; 2; 463-468.

(109) Nomura-Kitabayashi A, Kovacic JC. Mouse Model of Wire Injury-Induced Vascular Remodeling. Methods Mol Biol. 2018; 1816: 253-268.

(110) Williams JW, Giannarelli C, Rahman A, Randolph GJ, Kovacic JC. Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease. JACC Macrophage in CVD Series (Part 1). J Am Coll Cardiol. 2018; 72: 2166-2180.

(111) Moore KJ, Koplev S, Fisher EA, Tabas I, Björkegren JLM, Doran AC, Kovacic JC. Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis. JACC Macrophage in CVD Series (Part 2). J Am Coll Cardiol. 2018; 72: 2181-2197.

(112) Fayad ZA, Swirski FK, Calcagno C, Robbins CS, Mulder W, Kovacic JC. Monocyte and Macrophage Dynamics in the Cardiovascular System. JACC Macrophage in CVD Series (Part 3). J Am Coll Cardiol. 2018; 72: 2198-2212.

(113) Lavine KJ, Pinto AR, Epelman S, Kopecky BJ, Clemente-Casares X, Godwin J, Rosenthal N, Kovacic JC. The Macrophage in Cardiac Homeostasis and Disease. JACC Macrophage in CVD Series (Part 4). J Am Coll Cardiol. 2018; 72: 2213-2230.

(114) Kovacic JC, Dimmeler S, Harvey RP, Finkel T, Aikawa E, Krenning G, Baker A. Endothelial to Mesenchymal Transition in Cardiovascular Disease. J Am Coll Cardiol. 2019; 73(2): 190-209.

(115) Gornik HL, Persu A, Adlam D, Aparicio LS, Azizi M, Boulanger M, Bruno RM, De Leeuw P, Fendrikova-Mahlaya N, Froehlich J, Ganesh SK, Gray BH, Jamison C, Januszewicz A, Jeunemaitre X, Kadian-Dodov D, Kim ESH, Kovacic JC, Mace P, Morganti A, Sharma A, Southerland AM, Touze E, Van Der Niepen P, Wang J, Weinberg I, Wilson S, Olin JW, Plouin PF, on behalf of the Working Group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). First International Consensus on the Diagnosis and Management of Fibromuscular Dysplasia. Joint Publication, Vascular Medicine and Jnl of Hypertension 2019, 37:229–252.

(116) Kalkman DN, Aquino M, Claessen BE, Baber U, Guedeney P, Sorrentino S, Vogel B, de Winter RJ, Sweeny J, Kovacic JC, Shah S, Vijay P, Barman N, Kini A, Sharma S, Dangas GD, Mehran R. Residual inflammatory risk and the impact on clinical outcomes in patients after percutaneous coronary interventions. Eur Heart J. 2018; 39(46): 4101-4108.

(117) Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, O'Byrne MM, Bouajila S, Georges A, Mishra K, Braund PS, d’Escamard V, Huang S, Magaritis M, Nelson CP, de Andrade M, Kadian-Dodov D, Welch CA, Mazurkiewiczh S, Jeunemaitre X, DISCO Consortium, Wong CMY, Giannoulatou E, Sweeting M, Muller D, Wood A, McGrath-Cadell L, Fatkin D, Dunwoodie SL, Harvey R, Holloway C, Empana JP, Jouven X, CARDIoGRAMPlusC4D, Olin JW, Gulati R, Tweet MS, Hayes SN, Samani NJ, Graham RM, Motreff P, Bouatia-Naji N. Association of the PHACTR1/EDN1Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019; 73(1): 58-66.

(118) Robson P, Trivieri MG, Karakatsanis N, Padilla M, Abgral R, Dweck M, Kovacic JC, Fayad Z. Correction of Respiratory and Cardiac Motion in Cardiac PET/MR Using MR-Based Motion Modeling. Phys Med Biol. 2018; 63(22): 225011.

(119) Peng S, Deyssenroth MA, Di Narzo AF, Cheng H, Zhang Z, Lambertini L, Rusualepp A, Kovacic JC, Bjorkegren JLM, Marsit C, Chen J, Hao K. Genetic Regulation of the Placental Transcriptome Underlies Birth Weight and Risk of Childhood Obesity. PLoS Genetics. 2018; 14(12): e1007799.

(120) Guedeney P, Baber U, Claessen B, Aquino M, Camaj A, Sorrentino S, Vogel B, Farhan S, Faggioni M, Chandrasekhar J, Kalkman DN, Kovacic JC, Sweeny J, Barman N, Moreno P, Vijay P, Shah S, Dangas G, Kini A, Sharma S, Mehran R. Temporal trends, determinants, and impact of high-intensity statin prescriptions after percutaneous coronary intervention: Results from a large single-center prospective registry. Am Heart J. 2019; 207: 10-18.


(121) Zhang Z, Cheng H, Hong X, Di Narzo AF, Franzen O, Peng S, Ruusalepp A, Kovacic JC, Bjorkegren JLM, Wang X, Hao K. EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data. Nucleic Acids Res., 2019; 47(7): e39.

(122) Fernandez-Jimenez R, Jaslow R, Bansilal S, Santana M, Diaz-Munoz R, Latina J, Soto AV, Vedanthan R, Al-Kazaz M, Giannarelli C, Kovacic JC, Bagiella E, Kasarskis A, Fayad Z, Hajjar RJ, Fuster V. Child health promotion in underserved communities: The FAMILIA trial. J Am Coll Cardiol., 2019: 73: 2011-21.

(123) Guedeney P, Claessen BE, Kalkman DN, Aquino M, Sorrentino S, Giustino G, Fahran S, Vogel B, Sartori S, Montalescot G, Sweeny J, Kovacic JC, Krishnan P, Barman N, Dangas G, Kini A, Baber U, Sharma S, Mehran R. Residual Inflammatory Risk in Patients With Low LDL Cholesterol Levels Undergoing Percutaneous Coronary Intervention. J Am Coll Cardiol. 2019; 73(19): 2401-2409.

(124) Tang GHL, Zaid S, Gupta E, Ahmad H, Khan A, Kovacic JC, Lansman SL, Dangas GD, Sharma SK, Kini A. Feasibility of Repeat TAVR After SAPIEN 3 TAVR: A Novel Classification Scheme and Pilot Angiographic Study. JACC Cardiovasc Interv. 2019: 12(13): 1290-1292.

(125) Glicksberg BS, Amadori L, Akers NK, Sukhavasi K, Franzén O, Li L, Belbin GM, Akers KL, Shameer K, Badgeley MA, Johnson KW, Readhead B, Darrow BJ, Kenny EE, Betsholtz C, Ermel R, Skogsberg J, Ruusalepp A, Schadt EE, Dudley JT, Ren H, Kovacic JC, Giannareli C, Li SD, Björkegren JLM, Chen R. Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits. Accepted for publication, BMC Genomics, March 2019.

(126) Price LZ, Faries PL, McKinsey JF, Prakash K, Tang GH, Kovacic JC, Tadros RO. The Epidemiology, Pathophysiology, and Novel Treatment of Calcific Arterial Disease. Surg Technol Int. 2019; 34: 351-358.

(127) Zeng L, Talukdar H, Koplev S, Giannarelli C, Ivert T, Gan LM, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Michoel T, Schunkert H, Björkegren JLM. Major Contribution of Regulatory-Gene Networks to Coronary Artery Disease Heritability. J Am Coll Cardiol. 2019; 73(23): 2946-2957.

(128) Guedeney P, Claessen BE, Baber U, Camaj A, Sorrentino S, Aquino M, Blum M, Chandiramani R, Goel R, Elsayed S, Kovacic JC, Sweeny J, Barman N, Moreno P, Dangas GD, Kini A, Sharma S, Mehran R. Temporal Trends in Statin Prescriptions and Residual Cholesterol Risk in Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Am J Cardiol., 2019; 123(11): 1788-1795.

(129) Mahajan AM, Claessen BE, Chandrasekhar J, Sartori S, Aquino M, Baber U, Dangas G, Kovacic JC, Krishnan P, Moreno P, Sweeny J, Barman N, Vijay P, Kini A, Mehran R, Sharma S. Outcomes by Gender and Ethnicity After Percutaneous Coronary Intervention. Am J Cardiol. 2019 Mar 19. pii: S0002-9149(19)30316-9.

(130) Frades I, Readhead R, Amadori L, Koplev S, Talukdar HA, Crane HM, Crane PK, Kovacic JC, Dudley JT, Giannarelli C, Björkegren JLM, Peter I. Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy. Accepted for publication, Circulation: Genomic and Precision Medicine, April 2019.

(131) Tang GHL, Zaid S, Gupta E, Ahmad H, Patel N, Khan M, Khan A, Kovacic JC, Lansman SL, Dangas GD, Sharma SK, Kini A. Impact of Initial Evolut Transcatheter Aortic Valve Replacement Deployment Orientation on Final Valve Orientation and Coronary Reaccess. Circ Cardiovasc Interv. 2019; 12(7): e008044.

Editorials and commentaries (1) Kovacic JC and Graham RM. Stem-cell therapy for myocardial diseases. Lancet 2004; 363: 1735-

1736. (2) Kovacic JC and Graham RM. Are improvements in cardiac function due to stem cell uptake and

engraftment? Am J Cardiol. 2005; 95: 159.


(3) Kovacic JC. Further aspects of anemia, heart failure and erythropoietin. J Am Coll Cardiol. 2005; 45: 1549-1550.

(4) Kovacic JC, Harvey RP, Dimmeler S. Cardiovascular regenerative medicine: digging in for the long-haul. Cell Stem Cell. 2007; 1: 628-33.

(5) Kovacic JC, Macdonald P, Feneley MP, Graham RM. Granulocyte-colony stimulating factor in refractory ischemic heart disease. Am Heart J. 2009; 157: e39.

(6) Kovacic JC and Kini A. Inferior outcomes in Percutaneous Coronary Interventions: narrowing the gap between men and women. Interv Cardiol. 2011; 3: 119-121.

(7) Wiley JM, Krishnan P, Sanidas E, Kovacic JC, Dangas G. Technical Tips and Imaging in Aortoiliac Intervention. Endovascular Today, April 2011: 44-52.

(8) Kovacic JC and Randolph G. Vascular Calcification: Harder Than It Looks. Arterioscler Thromb Vasc Biol. 2011; 31: 1249-1250.

(9) Sharma AB, Kovacic JC, Kini AS. DAPT Management for Noncardiac Surgery After PCI. Cardiac Interventions Today, Jan/Feb 2012: 26-31.

(10) Kovacic JC and Fuster V. Vascular Calcification, Diabetes and Cardiovascular Disease – Connecting the Dots. JACC Cardiovasc Imaging. 2012; 5: 367-369.

(11) Sharma AB, Kovacic JC, Sharma SK. The Szabo Technique in a Patient with Ostial RCA In-Stent Restenosis. Cardiology Today Intervention, March/April 2012.

(12) Kovacic JC and Fuster V. Smoking Gun Theory: Angiographically Normal or Mild Coronary Plaque as a Cause of Myocardial Infarction. Circulation 2012; 126: 2918-2920.

(13) Roleder T, Suh W, Sharma R, Hecht H, Kovacic JC, Narula J, Kini AS. Plaques with High Lipid Burden: Keeping the Fat Out of the Fire. Heart 2013; 99: 977-978.

(14) Kovacic JC and Kini A. Pharmacological Therapy of Lipid Core Plaque. J Invasive Cardiol. 2013; 25: 27A-28A.

(15) Narula J and Kovacic JC. Putting TCFA in Clinical Perspective. J Am Coll Cardiol. 2014; 64(7): 681-3.

(16) Kovacic JC and Fuster V. Cell Therapy For Patients With Acute Myocardial Infarction: The ACCRUEd Evidence to Date. Circ Res. 2015; 116: 1287-1290.

(17) Kovacic JC. Un-locking the Many Secrets of Non-coding RNA. J Am Coll Cardiol. 2015; 65: 2538-2541.

(18) Kovacic JC. Unraveling the complex genetics of coronary artery disease. J Am Coll Cardiol. 2017; 69: 837-40.

(19) Hajjar RJ, Ishikawa K, Kovacic JC, Fuster V. Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai - Translational Mission. Circ Res 2017; 121: 1316-1319.

(20) Kovacic JC. The Endothelial-Metabolic Axis: A Novel Cardiometabolic Disease Target. Trends Endocrinol Metab. 2018; 29(8): 527-529.

Book Chapters (1) Kovacic JC and Fuster V. Cardiovascular Disease: From treatment to promoting health; a challenge

for the next decade. In: Atherosclerosis: The 21st Century Epidemic. Edited by Conrado J. Estol and Marcelo Sánchez Sorondo. Pontificiae Academiae Scientiarvm, Vatican City, 2011, pages 108-116.

(2) Castellano JM, Kovacic JC and Fuster V. Atherothrombosis. In: Panvascular Medicine. Edited by Peter Lanzer. Springer-Verlag Berlin Heidelberg, 2015, pages 245-271.

(3) Rocha VZ, Tomey M, Libby P, Fuster V, Kovacic JC. The Pathogenesis of Atherothrombosis. In: Cardiovascular Medicine - Reducing the Disease Burden. Edited by Roberto Kalil and Valentin Fuster. Atheneu Publishing, Brazil, 2016, pages 375-406.

(4) Tomey M, Kini AS, Sharma SK, Kovacic JC. Aortic Valvuloplasty and Large-Bore Percutaneous Arterial Access. In: Interventional Cardiology: Principles and Practice, 2e. Edited by George Dangas, Carlo Di-Mario, Nicholas Kipshidze. Wiley Blackwell Publishing, Oxford, UK, 2017. Chapter 58; pages 546-557.


(5) Johnston-Cox H, Björkegren JLM, Kovacic JC. Genetics and Pharmacogenetics in Interventional Cardiology. In: Interventional Cardiology: Principles and Practice, 2e. Edited by George Dangas, Carlo Di-Mario, Nicholas Kipshidze. Wiley Blackwell Publishing, Oxford, UK, 2017. Chapter 48; pages 459-468

(6) Johnston-Cox H, Fuster V, Kovacic JC. Biology of the vessel wall. In: Hurst’s the Heart, 14th Edition. Edited by Valentin Fuster, Robert Harrington, Jagat Narula, Zubin Eapen. The McGraw-Hill Companies Publishing, Columbus, OH. Chapter 7; pages 144-160.

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