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Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
Plant Genomics Research in Germany - GABI
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 2Jens Freitag; Wageningen, October 2005
Plant Genomics Research at all
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 3Jens Freitag; Wageningen, October 2005
Plant Genome Research
is a continuous development as a natural consequence of plant sciences in the 21st century. It is the bridge between classical molecular biology and the future comprehensive and holistic research approaches. The system-oriented understanding of plants (systems oriented biology) and their interaction with the environment (systems ecology) are moving more and more into the focus of our research. Plant genomic programs are necessary to bundle these activities and to form much needed competence clusters.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 4Jens Freitag; Wageningen, October 2005
Central Goal of Plant Genomics Research
Create knowledge that allows the development of novel, advanced products that fulfill future demands.
Plants have to be recognized as technology carriers to create the “Plants for the Future”.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 5Jens Freitag; Wageningen, October 2005
Major Global Trends = Future Demands:
pollution/emission and global environmental changes increased world population scarceness of food, water, energy and other resources unemployment urbanization income disparity within and between societies aging society (collapse of social security systems) instability of political and economical systems
What contributions could biotechnology & functional genomics make?
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 6Jens Freitag; Wageningen, October 2005
What are the answers to these global challenges?
Securing healthy and safe food supplies for the growing global population (with less arable land available)
Achieving a sustainable, resource-saving and environmentally friendly agriculture
Agricultural production of raw materials and energy sources Development of bio-based industries using renewable resources Retaining agriculture as the „Engine of Change“ in developing
countries Creating and maintaining a pleasant and natural environment
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 7Jens Freitag; Wageningen, October 2005
Plus Contributions to the Solution of Regional Problems:
Economically productive agriculture and rural development (employment opportunities and participation in the value creation chain)
Adaptation of crops to changing environmental conditions (biotic and abiotic)
Adaptation of crops to low-input farming systems Changing life styles with altered demands on products Aging population with new dietary requirements High energy demand faced with a declining supply of fossil fuels
and the projected stop to nuclear power (GE) Environmental conservation and diverse and pleasant countryside
(recreation)
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 8Jens Freitag; Wageningen, October 2005
Plant genomics will play an important role in answering pending global questions, but will never be the only answer!
Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
Plant Genomic Research in Germany – GABI
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 10Jens Freitag; Wageningen, October 2005
German Plant Genomics in Context
In Germany, two bigger plant genomic research networks exist: The Arabidopsis Functional Genomics Network (AFGN) as an associative
research program of the “German Research Foundation” (DFG) supports Arabidopsis functional genomics with 2 million €. The AFGN is jointly coordinated with the US National Science Foundation ‘Year 2010’ program.
Goal: Elucidating the function of all Arabidopsis genes until 2010. The German plant genomic program GABI combines activities on model
species and crop plants.
Goal: Determining the structure and biological function of the Arabidopsis and barley genomes, and portions of the genomes of important cultivated plants used as research models. Using this information to implement applied research goals.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 11Jens Freitag; Wageningen, October 2005
Twelve plant genomes are being studied within GABI:
Arabidopsis thaliana and barley (Hordeum vulgare) serve as model organisms for mono- and dicotyledonous plants. The results of these two model organisms will support the analysis of genomes on the crop plants rape seed, sugar beet, potato, rye, wheat, maize, tomato and grape. Pine and oak are tree organisms examined.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 12Jens Freitag; Wageningen, October 2005
The research activities within GABI are assigned to two areas:
· Research Area I focuses on basic research activities (100% funded by the BMBF).
· Research Area II bundles activities with more applied character (100% funding of research activities in academia and 50-60% co-financing of research activities within private companies).
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 13Jens Freitag; Wageningen, October 2005
GABI 2 (2004 – 2007)
· Political decision was made to continue GABI in a second program period
· Evaluation of running projects at the end of 2002
· Call for proposals was published in 2003
· Deadline to submit GABI 2 proposals in June 30, 2003
· External and internal reviewing process was finished in October
· Second phase of the GABI initiative started in 2004 (continuation of running projects + new projects)
· Stronger focus on application oriented research (transfer from models to crops; “bridge project concept”)
· Up to 25% of the GABI 2 public budget was claimed to promote international co-operation
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 14Jens Freitag; Wageningen, October 2005
The GABI Network in 2004
An important aim of GABI is to stimulate the formation of competence clusters all over Germany and to interlink these clusters. Competence clusters can be public research institutions as well as private institutions.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 15Jens Freitag; Wageningen, October 2005
The Public-Private Partnership
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 16Jens Freitag; Wageningen, October 2005
Business Platform Promoting GABI (WPG):
The WPG is a registered association seated in Bonn. The purpose of the association is the promotion of research – especially GABI. Initiated by industry, this organization has succeeded in achieving two essential aims:
Establishment of a central contact partner for industry on matters of policy, science, and economy as well as for all other GABI bodies.
Coordination of the activities of the companies participating in GABI and joint definition of binding proceedings and rules for members within the framework of the promotion regulations of the BMBF.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 17Jens Freitag; Wageningen, October 2005
Currently 25 companies are members
These companies are active in different sectors: Plant breeders (21) Agro-chemical industry (2) Food processing (1) Start-ups (1)
That means small and medium-sized enterprises and globally acting companies are members within the same association.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 18Jens Freitag; Wageningen, October 2005
Guidelines of the Business Platform Promoting GABI
Bringing together Germany's existing research capabilities and coordinately transforming its research infrastructure into an integrated network
Connecting the interests of science and industry Establishing the promotion of quality research and creating favorable
conditions for direct industry participation Creating technology transfer strategies promoting the efficient
transformation of research results into innovative products Guaranteeing comprehensive patent coverage Preserving the autonomy of participating companies: Every individual
company may decide freely the way and extent to which it participates in GABI projects.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 19Jens Freitag; Wageningen, October 2005
The Patent and Licensing Agency (PLA for GABI)
To support the VISION of knowledge spillover from academia to companies
Goals and Tasks:
Assistance in contract negotiations and conclusions
Contact prior to publications (screening for utilization relevant results)
Basic cost absorption for patents (initial application and patent attorney)
Only of relevance for Research Area I = in general no industrial partners involved into the projects.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 20Jens Freitag; Wageningen, October 2005
Funding of Genome Research by the BMBF (€/Y)
German Human Genome ProjectDHGP 1996 – 2004National Human Genome Research Network NGFN 2001 – 2007Plant Genome Research ProgramGABI 1999 – 2007Genome Research on BacteriaGenoMik 2001 – 2006Genome Research in LivestockFUGATO 2005 – 2010Proteome Research since 2001Bioinformatics since 2001Systems Biology of the Liver cell since 2004 HepatoSysSystems Biology of Bacteria SysMo 2007-2015
Total:
23 Mio
45-50 Mio
10 Mio
10 Mio
2,7 Mio
10 Mio8 Mio
5-12 Mio
n.n. Mio
ca. 100 Mio
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 21Jens Freitag; Wageningen, October 2005
Public Private Partnership in Genome Research
Industrial Association to support Human Genome Research „Förderverein e.V.”
Business Platform promoting GABI Plant Genome Research „Wirtschaftsverbund Pflanzen-genomforschung”GABI e.V.“ (WPG)
Industrial Association to support Animal Genomics „Industrieverbund FUGATO e.V.“
Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
The European landscape of genomics
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 23Jens Freitag; Wageningen, October 2005
The ERA Net Plant Genomics
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 24Jens Freitag; Wageningen, October 2005
What are the objectives of the ERA Net PG?
creation of an European internal market for Plant Genomics
to avoid fragmentation, to identify synergies to encourage co-operation and co-ordination between
the national/regional programs to facilitate the opening of national programs to establish transnational joint programs
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 25Jens Freitag; Wageningen, October 2005
The ERA Net as a success story for Europe
The structuring effect of the ERA Net is immense. Harmonization Transparency Development of efficient funding structures Synergies
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 26Jens Freitag; Wageningen, October 2005
The ERA Net PG – Insights from GABI Perspective
For nations the voluntary cooperation is an advantage of the ERA Net PG
The ERA Net is the meeting point for countries willing to cooperate on topics of high interest for a nation/region.
Alibi partners are avoided by the fact that every country has to bring its own grant.
A common pot could be a need for a unified Europe in the long term. In the near future a common pot does not seem to be a practical
solution. Higher level assembled political reasons might change this national
orientation.
Genomanalyse im Biologischen System Pflanze
GABI-Managing Office (www.gabi.de) 27Jens Freitag; Wageningen, October 2005
Plant Genomics Researchis not only a need of the 21st century, Plant Genomics Research is an example for joint national and international research activities.
Génoplante – GABI (1st phase 2002) Génoplante – GABI (1st and 2nd phase 2004; PPP) MEyC – Génoplante – GABI (1st phase, 2004; first int. co-operation under the ERA PG) ERA Net Plant Genomics (1st call 2005/06)
`MEyC – Génoplante – GABI – plus´ (2nd phase, 2006; PPP) Technology Platform „Plants for the Future“ (FP7 2007-2013)
Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
The future landscape of genomics in Germany
Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
GABI-FUTURE (2007-2016) - a building block on the way to a ‘Bio-Based‘ Industry. As a developed and proven PPP GABI-FUTURE bundles innovative, basic research oriented activities with application oriented developments. International cooperation is the basis for GABI-FUTURE. The networking with other national programs in line with the concept of integrated life sciences underpins the interdisciplinary character of GABI-FUTURE.
GABI Future
International Cooperation
TP ‘Plants for the Future‘ERA Net PG
GE – FRGE – FR - SPGE – CAN...
GABI Netzwerk
GABI-Basics
Basic Research, Systems-Biology, Technologies and Resources
GABI-Breeding
Applied Research in Plant Breeding and Plant Biotechnology
National Programs
Integrative Life Sciences
GenoMikSysMoFUGATONeMoNGFN…
Jens Freitag (GABI Managing Office / www.gabi.de) Genomics in Business 2006
Thank you for your attention.