WELCOME WELCOME

Joe Keil www.whenjustsaynodoesntwork.com 920-323-2354

How do we win

How do we win

a war on drugs

a war on drugs

that we have

that we have

lost for the past

lost for the past

40+ years?40+ years?

PREVENTION!

PREVENTION!

UNITED STATES HAS ? of UNITED STATES HAS ? of the WORLD POPULATIONthe WORLD POPULATION

CONSUMES ? % of the Worlds CONSUMES ? % of the Worlds ILLEGAL DRUGSILLEGAL DRUGS

STA

TS

STA

TS

NYC consumes 10 tons of illegal drugs NYC consumes 10 tons of illegal drugs each dayeach day

121 Million Scripts for Hydrocodone in 121 Million Scripts for Hydrocodone in 20122012

20% of people who take Benadryl become 20% of people who take Benadryl become stimulated stimulated

Illegal Drug Business is a 400 billion Illegal Drug Business is a 400 billion marketmarket

Meth: 2011 MS 2096, TN 1687, ID 1437 Meth: 2011 MS 2096, TN 1687, ID 1437 and KY 1188and KY 1188

20% of people in US using pills for no 20% of people in US using pills for no reasonreason

More people are using Pills than Cocaine, More people are using Pills than Cocaine, Heroin, Hallucinogens and Inhalants Heroin, Hallucinogens and Inhalants COMBINEDCOMBINED

2010 2.4 million people tried Marijuana for 2010 2.4 million people tried Marijuana for the first timethe first time

2010 2.2 million tried pain pills for the first 2010 2.2 million tried pain pills for the first time time

Trivia Trivia

Question:Question:

What does RX mean?

What does RX mean?

In 2

001 C

hange

In 2

001 C

hange

in V

ital S

igns

in V

ital S

igns

Respirations

RespirationsHeart rateHeart rateBlood pressure

Blood pressureBody temperature

Body temperature Big Change: PAIN was

Big Change: PAIN was

added added

6 T

ypes

of

Dru

gs

6 T

ypes

of

Dru

gs

OTCOTCRX Prescription

RX PrescriptionRX Controlled

RX Controlled Controlled Illegal

Controlled Illegal Street Drugs

Street DrugsDesigner Drugs

Designer DrugsHerbal Herbal

Types

of

Dru

g

Types

of

Dru

g

Use

Use

Experimentation: Trying

Experimentation: Trying

a substance by choice

a substance by choice

or by peer pressure

or by peer pressure Abuse: using a drug to

Abuse: using a drug to

get highget high

Addiction: When the

Addiction: When the

physical harm to your

physical harm to your

body and your life no

body and your life no

longer matters!

longer matters!

EYE EXAM and Drug InfluenceEYE EXAM and Drug InfluenceIII-1

M-U-R-D-E-R-S, I-N-C, IM-U-R-D-E-R-S, I-N-C, I

VI-3A

The Eleven Systems of The Eleven Systems of Human Physiology: Human Physiology: Murders, Murders,

Inc. IInc. IM is for Muscular SystemU is for Urinary SystemR is for Respiratory SystemD is for Digestive SystemE is for Endocrine SystemR is for Reproductive SystemS is for Skeletal System

I is for Integumentary systemN is for Nervous System*C is for Circulatory System*I is for Immune System VI-3B

Muscular SystemMuscular System The body has three different The body has three different

kinds of muscleskinds of muscles

The heart, or cardiac muscleThe heart, or cardiac muscle

Smooth muscles, which control Smooth muscles, which control the body’s involuntary the body’s involuntary operationsoperations

Striated muscles, which carry Striated muscles, which carry out our voluntary movementsout our voluntary movements

Urinary SystemUrinary System• This system consists of two This system consists of two

kidneys, the bladder, ureters kidneys, the bladder, ureters connecting the kidneys to the connecting the kidneys to the bladder, and the urethra, bladder, and the urethra, which transports the urine out which transports the urine out of the bodyof the body

• Kidneys filter waste or Kidneys filter waste or harmful products, such as harmful products, such as drugs and their metabolites, drugs and their metabolites, from the blood, and dump from the blood, and dump these waste products into the these waste products into the bladder. bladder. What the Hell is a What the Hell is a metabolite?metabolite?

Respiratory SystemRespiratory System The major parts of the Respiratory System The major parts of the Respiratory System

are the lungs and the diaphragmare the lungs and the diaphragm

The diaphragm is a smooth muscle that The diaphragm is a smooth muscle that draws the air into the lungs and forces it draws the air into the lungs and forces it outout

Lungs take oxygen and transfer it to the Lungs take oxygen and transfer it to the blood, and remove carbon dioxide and blood, and remove carbon dioxide and some other waste products from the some other waste products from the blood, and expel them into the outside air blood, and expel them into the outside air

Digestive SystemDigestive SystemMajor components of this system are the Major components of this system are the

tongue, teeth, esophagus, stomach, tongue, teeth, esophagus, stomach, intestines, liver and pancreasintestines, liver and pancreas

The Digestive System breaks down large The Digestive System breaks down large particles of food, until they are of a size particles of food, until they are of a size and chemical composition that can be and chemical composition that can be absorbed in the bloodabsorbed in the blood

Endocrine SystemEndocrine System• The Endocrine System is made up of a The Endocrine System is made up of a

number of different glands, that secrete number of different glands, that secrete hormoneshormones

• Hormones are complex chemicals that Hormones are complex chemicals that travel through the blood stream and that travel through the blood stream and that control or regulate certain body processescontrol or regulate certain body processes

• Some drugs can mimic the effects of Some drugs can mimic the effects of hormones, or can react with the hormones hormones, or can react with the hormones in ways that alter the hormones’ effectsin ways that alter the hormones’ effects

Reproductive SystemReproductive System The functions of the The functions of the

Reproductive System fall into Reproductive System fall into two roles 1. Self producing two roles 1. Self producing (cytogenic) 2. Hormone (cytogenic) 2. Hormone producing (endocrinic)producing (endocrinic)

We are primarily concerned We are primarily concerned with hormone production with hormone production since the hormones produced since the hormones produced by the Reproductive System by the Reproductive System aid the nervous system in its aid the nervous system in its regulatory roleregulatory role

Skeletal SystemSkeletal SystemConsists of bones, cartilage and ligamentsConsists of bones, cartilage and ligaments

The Skeletal System provides support to The Skeletal System provides support to the body, permits movement, and forms the body, permits movement, and forms blood cellsblood cells

It is however, affected by drug abuse, we It is however, affected by drug abuse, we just may not be able to see it just may not be able to see it

19811982 1985 My Prom Date

Integumentary SystemIntegumentary SystemConsists of skin, hair, finger and toe nails, Consists of skin, hair, finger and toe nails,

and accessory structuresand accessory structures

The chief functions of the Integumentary The chief functions of the Integumentary System include protection of the body, System include protection of the body, control of body temperature, excretion of control of body temperature, excretion of wastes (i.e. through the sweat) and wastes (i.e. through the sweat) and sensory perceptionsensory perception

Outside Temperature 14Outside Temperature 14

Nervous SystemNervous System This system consists of the brain, This system consists of the brain,

the brain stem, the spinal cord and the brain stem, the spinal cord and the nervesthe nerves

Nerves keep the brain informed of Nerves keep the brain informed of changes in the body’s external and changes in the body’s external and internal environmentsinternal environments

Nerves also carry messages from Nerves also carry messages from the brain to the body’s muscles, the brain to the body’s muscles, tissues and organstissues and organs

The Nervous System controls, The Nervous System controls, coordinates and integrates all coordinates and integrates all physiological process, so the normal physiological process, so the normal body functions can be maintainedbody functions can be maintained

Circulatory SystemCirculatory System

• For our purposes, the Circulatory For our purposes, the Circulatory System consists of the heart, the System consists of the heart, the blood vessels (veins and arteries), blood vessels (veins and arteries), and the bloodand the blood

• Blood carries food, water, oxygen, Blood carries food, water, oxygen, hormones, antibodies etc. to the hormones, antibodies etc. to the tissues and organstissues and organs

• Blood also carries heat through the Blood also carries heat through the bodybody

• Blood is the main carrier that Blood is the main carrier that brings drugs to the brainbrings drugs to the brain

• The heart pumps and forces the The heart pumps and forces the blood to circulate through the bodyblood to circulate through the body

IMMUNE SYSTEMIMMUNE SYSTEM The immune system protects against The immune system protects against

disease by destroying “foreign” cells and disease by destroying “foreign” cells and by inactivating toxins and other foreign by inactivating toxins and other foreign chemicals with its antibodies.chemicals with its antibodies.

HomeostasisHomeostasis• The human body is exposed to constantly The human body is exposed to constantly

changing changing externalexternal environment. environment.• Changes are neutralized by theChanges are neutralized by the internal internal

environment – the bloodenvironment – the blood• Oxygen, foods, water and other Oxygen, foods, water and other

substances are constantly leaving body substances are constantly leaving body fluids to enter cells, while carbon dioxide fluids to enter cells, while carbon dioxide and other wastes are leaving the cells to and other wastes are leaving the cells to enter these fluidsenter these fluids

• Yet the chemical composition of these Yet the chemical composition of these fluids remains within very narrow limitsfluids remains within very narrow limits

• This phenomenon is called homeostasisThis phenomenon is called homeostasis

Homeostasis: is the key to drug use: the Homeostasis: is the key to drug use: the body is out of balancebody is out of balance

Dynamic balance or steady state involving levels of salts, water, sugars and other material

in the body’s fluidsVI-3D

When y

our

sick

When y

our

sick

You take meds to put

You take meds to put

your body back into

your body back into balancebalanceWhen you take drugs

When you take drugs

to get high it is done

to get high it is done

to put your body out

to put your body out

of balance to feel high

of balance to feel high

or feel good.

or feel good.

The Male Brain compared to the The Male Brain compared to the Female BrainFemale Brain

Seriously

Seri

ousl

y Seri

ousl

y

Addin

g E

TO

H t

o

Addin

g E

TO

H t

o

Date

Nig

ht

Date

Nig

ht

Afferent

Sensory Nerves

Motor Nerves

Efferent

Voluntary Autonomic

Parasympathetic Sympathetic

Afferent

Sensory Nerves

Motor Nerves

Efferent

Voluntary Autonomic

Parasympathetic Sympathetic

Fundamental NotionsFundamental Notions If something interferes with the messages to If something interferes with the messages to

the brain sent along the motor nerves, the the brain sent along the motor nerves, the brain’s control over the heart, the lungs, the brain’s control over the heart, the lungs, the muscles and other organs will be distortedmuscles and other organs will be distorted

If something interferes with the messages If something interferes with the messages the brain receives from the sensory nerves, the brain receives from the sensory nerves, the brain’s perception of the outside world the brain’s perception of the outside world and of the body’s status will be distortedand of the body’s status will be distorted

THIS IS HOW DRUGS WORK ON THE THIS IS HOW DRUGS WORK ON THE FUNCTIONING OF THE NERVOUS SYTEMFUNCTIONING OF THE NERVOUS SYTEM

Motor NervesMotor Nerves• There are two sub-systems of motor There are two sub-systems of motor

nerves:nerves:– The The voluntary nervesvoluntary nerves send messages to the send messages to the

striated muscles that we consciously controlstriated muscles that we consciously control

– The The autonomic nervesautonomic nerves send messages to the send messages to the muscles and organs that we do not consciously muscles and organs that we do not consciously control, i.e., smooth muscle and cardiac musclecontrol, i.e., smooth muscle and cardiac muscle

The Autonomic Sub-SystemThe Autonomic Sub-System

• The Autonomic Sub-System divides into The Autonomic Sub-System divides into two groups:two groups:– First, the First, the Sympathetic nervesSympathetic nerves command the command the

body to react in response to fear, stress, body to react in response to fear, stress, excitement, etc.excitement, etc.• ““Fight or Flight” Responses:Fight or Flight” Responses:

– Blood pressure elevatedBlood pressure elevated

– Pupils to dilatePupils to dilate

– Sweat glands to activateSweat glands to activate

– Hair to stand on endHair to stand on end

– Heart beat to increase and strengthenHeart beat to increase and strengthen

– Blood vessels of the skin to constrictBlood vessels of the skin to constrict

– Inhibited digestionInhibited digestion

The Autonomic Sub-SystemThe Autonomic Sub-System• Second, the Second, the Parasympathetic nervesParasympathetic nerves carry carry

messages that produce relaxed and messages that produce relaxed and tranquil activitiestranquil activities– Pupils to constrictPupils to constrict

– Heartbeat to slowHeartbeat to slow

– Peripheral blood vessels to dilatePeripheral blood vessels to dilate

– Blood pressure to decreaseBlood pressure to decrease

– Digestion to be facilitatedDigestion to be facilitated

Drugs & the Autonomic Sub-Drugs & the Autonomic Sub-SystemsSystems

• Some drugs mimic the neurotransmitters Some drugs mimic the neurotransmitters that travel in the Sympathetic and that travel in the Sympathetic and Parasympathetic nerve systemsParasympathetic nerve systems

• Drugs that mimic neurotransmitters in the Drugs that mimic neurotransmitters in the Sympathetic system are called Sympathetic system are called SympathomimeticSympathomimetic drugs. These drugs will drugs. These drugs will artificially create the same effects.artificially create the same effects.

• Drugs that mimic neurotransmitters in the Drugs that mimic neurotransmitters in the Parsympathetic system are called Parsympathetic system are called ParasympathomimeticParasympathomimetic drugs. These drugs drugs. These drugs will artificially create the same effects. will artificially create the same effects.

A Simplified Concept of a A Simplified Concept of a NerveNerve

The nerves that carry messages The nerves that carry messages to and from the brain often are to and from the brain often are pictured as “wires” or “telephone pictured as “wires” or “telephone wires” that carry electrical signalswires” that carry electrical signals

A more accurate, but still A more accurate, but still simplified concept would envision simplified concept would envision a nerve as a series of broken wire a nerve as a series of broken wire segments, with the segments segments, with the segments separated by short spaces, or separated by short spaces, or gapsgaps

Simple Concept Simple Concept of a Nerveof a Nerve

How does this affect How does this affect your health?your health?

The a

bso

rbti

on

and e

limin

ati

on o

f dru

gs Alcohol is a fixed rate

at ?Drugs are ½ lives What is a half life and

how does it work?

½ li

ves

Lets say a drugs half

life is 5 hoursThat simply means every 5 hour half of the drug is gone

Therefore the first 5 hours the majority of

the drug is gone or half of it. There are usually

about 8 half lives

ADDITIVE EFFECT

Effect Effect

1 + 1 = reinforced 1

NULL EFFECT

No Effect No Effect

0 + 0 = 0

OVERLAPPING EFFECT

No Effect Effect

0 + 1 = 1

ANTAGONISTIC EFFECT

Effect OppositeEffect

1 + -1 = ????