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Developmental Statusof 1-Year-Old InfantsFed Breast Milk, Cows

Milk Formula, or SoyFormula

M. Aldiansyah J.,S.Ked04114708045Pembimbing:Dr.Hj.Rismarini, Sp.A(K)

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Latar BelakangAlthough soy formula has been reported to

support normal development, concerns existregarding potential adverse developmental

effects of phytochemicals associated with soyprotein.

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TujuanThis study characterized developmental

status (mental, motor, and language) ofbreastfed (BF), milk-bassed formula-fed (MF),

or soy protein-based formula-fed (SF) infantsduring the first year of life.

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MetodeParticipants:Participants were 391 infants enrolled in the

Beginnings study between 2002 and 2010.

Infants were recruited between ages 1 and 2monts.

Pregnancies were uncomplicated with nomedical diagnose or medications known to

affect fetal or infant growth and development.

All mothers were nonsmokers, were deniedalcohol use during pregnancy, and reportedno use of soy products or other estrogeniccompounds during pregnancy and/or

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Metode (cont...)participants:Infants were term (>37 weeks), 2,7 kg to 4,1

kg at birth, had no medical diagnoses, or hadnot been administered medications known to

affect growth ar development.

Other exclusion criteria included change offormula after age 2 months and before age 12

months; complementary foods before 4months; and body weight at 3 months < 5 kg.

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MetodeInfant Diet:

Parentsfollowingthe advise

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Metodeanthropometrics:Anthropometric measured were obtained at

each study visit by using standardizedmethods.

Briefly, infant weight was measured to thenearest 0.01 kg by using a tarred scale withinfants wearing a diaper only.

Infant length was measured to the nearest 0.1cm by using a length board.

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MetodeInfant Behavioral Development:Infant were assessed with the Bayley Scaled

of Infant Development (BSID), second edition,from which the Mental Developmental Index

(MDI) and Psychomotor Development Index(PDI) were derived.

Infants were also assessed with the preschool

language Scale-3 (PLS-3) by using theexpressive communication and auditorycomprehension subscales.

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Metode

Infant Behavioral Development:(cont...)Result are presented as standard scores

adjusted for childs age with a mean of 100(SD=15), and the range for normal scores is

85-115.

Delay on these measures was defined as ascore below 85 and accelerated performance

a score greater than 115.Both assessments were administered at each

study visit by psychological examinerssupervised by a licensed psychologist.

All examiners were blinded to feeding group

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Metode

Scale of Intelligence

Sosioeconomic Status

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Hasil :Of 483 potential participants, 49 (10.1%) were

excluded because they did not meet inclusioncriteria, and 8 (1.6%) were exclude because of

a medical diagnosis.

Of the remaining 426 participants, 35 (8.2%)voluntary withdrew or were lost to follow-up.

The final cohort analyses consisted of 131 BFinfants (61 girls), 131 MF infants (61 girls),and 129 SF infants (55 girls), for a total 391infants.

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MDI Score Estimated From Fitted Mixed

Models3 mo 6 mo 9 mo 12 mo

BF 103.08(0.57)

108.56(0.44)a

108.67(0.44)a

103.81(0.57)a

MF 102.61(0.58)

107.31

(0.45)ab

106.56

(0.45)b

100.86

(0.59)b

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PDI Score Estimated From Fitted Mixed

Models3 mo 6 mo 9 mo 12 mo

BF 98.66 (0.84)a 103.57(0.70)a

103.31

(0.70)

98.26

(0.85)MF 97.27

(0.86)ab102.07

(0.72)ab101.68(0.72)

96.64(0.87)

SF 95.18 (0.88)b 100.64(0.73)b

100.87

(0.73)

96.37

(0.89)P value .0484 .0397 .1418 .8838

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PLS-3 Score Estimated From Fitted

Mixed Models3 mo 6 mo 9 mo 12 mo

BF 98.98 (0.63)a 104.87(0.48)a

104.55(0.48)

98.26(0/64)

MF 95.89 (0.65)b 102.69(0.49)b

103.23(0.49)

97.82(0.66)

SF 97.40(0.66)ab

103.80(0.50)ab

103.92(0.50)

98.03(0.67)

P value .0069 .0101 .4625 1.0000

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HASIL

No differences were foundbetween formula-fed infants (MF

versus SF).BF infant score slightly higher than

formula-fed infants on the Mental

Developmental Index (MDI) scoreat ages 6 and 12 months (P < .05).

Infants who were breastfed alsohad higher Psychomotor

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Kesimpulan

Studi ini menunjukan perkembangan mentalpada grup bayi yg mengkonsumsi susu sapidan susu kedelai berada dalam batas normal

dan tidak berbeda terlalu signifikan.

Studi ini juga menunjukan keuntunganpekembangan kongnitif pada bayi ygmengkonsumsi ASI di banding ygmengkonsumsi susu formula.

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Yes.

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Apa yang menjadi masalah utama padapenelitian ini?

Susu kedelai yg sudah diketahui dapatmenyuport perkembangan mental normal,timbul kekhawatiransehubungan dengan

potensi efek merugikan dari phytochemical ygterkandung pada protein kedelai.

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This study characterized developmentalstatus (mental, motor, and language) ofbreastfed (BF), milk-bassed formula-fed (MF),or soy protein-based formula-fed (SF) infants

during the first year of life.

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